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Conserved domains on  [gi|115583677|ref|NP_008851|]
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sodium channel protein type 1 subunit alpha isoform 2 [Homo sapiens]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-707 1.61e-97

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 310.90  E-value: 1.61e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPE----------GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMS 704
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 115583677   705 IAS 707
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
995-1202 1.23e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.23e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   995 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1073
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1074 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1148
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 115583677  1149 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1202
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1206-1481 1.78e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.78e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1206 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1284
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1285 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1364
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1365 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1444
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 115583677  1445 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1529-1785 1.26e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.72  E-value: 1.26e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1529 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1605
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1606 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1685
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1686 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1763
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 115583677  1764 LVVVNMYIAVILENFSVATEES 1785
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
756-969 9.64e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.64e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   756 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 833
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   834 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 910
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   911 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 969
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.76e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.53  E-value: 1.76e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115583677   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 4.71e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.71e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 115583677 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1525
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-707 1.61e-97

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 310.90  E-value: 1.61e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPE----------GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMS 704
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 115583677   705 IAS 707
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
995-1202 1.23e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.23e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   995 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1073
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1074 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1148
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 115583677  1149 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1202
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1206-1481 1.78e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.78e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1206 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1284
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1285 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1364
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1365 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1444
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 115583677  1445 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1529-1785 1.26e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.72  E-value: 1.26e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1529 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1605
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1606 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1685
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1686 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1763
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 115583677  1764 LVVVNMYIAVILENFSVATEES 1785
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
756-969 9.64e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.64e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   756 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 833
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   834 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 910
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   911 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 969
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.76e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.53  E-value: 1.76e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115583677   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 4.71e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.71e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 115583677 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1525
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-707 1.61e-97

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 310.90  E-value: 1.61e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPE----------GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMS 704
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 115583677   705 IAS 707
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
995-1202 1.23e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.23e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   995 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1073
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1074 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1148
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 115583677  1149 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1202
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1206-1481 1.78e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.78e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1206 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1284
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1285 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1364
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1365 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1444
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 115583677  1445 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1529-1785 1.26e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.72  E-value: 1.26e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1529 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1605
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1606 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1685
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1686 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1763
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 115583677  1764 LVVVNMYIAVILENFSVATEES 1785
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
756-969 9.64e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.64e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   756 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 833
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   834 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 910
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   911 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 969
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.76e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.53  E-value: 1.76e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115583677   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 4.71e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.71e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 115583677 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1525
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1567-1779 8.45e-05

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 46.12  E-value: 8.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1567 LVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAelIEKYFVSPTLFRVI-----------RLARIGRI 1635
Cdd:pfam08016   18 VVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1636 LRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAyvkrevgiDDMFNFETF 1699
Cdd:pfam08016   96 YRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNF 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115583677  1700 GNSMICLFQITTSA-GWDGLlapilnskppdcdpnkvnpgssvkgDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1778
Cdd:pfam08016  168 VKSILTLFRTILGDfGYNEI-------------------------FSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222

                   .
gi 115583677  1779 S 1779
Cdd:pfam08016  223 V 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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