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Conserved domains on  [gi|27262647|ref|NP_009176|]
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ataxin-2-like protein isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
123-196 1.64e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.64e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
264-326 1.56e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.56e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
398-942 1.11e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983
                         570
                  ....*....|...
gi 27262647   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
123-196 1.64e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.64e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
264-326 1.56e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.56e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
398-942 1.11e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983
                         570
                  ....*....|...
gi 27262647   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
829-991 4.71e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 4.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    829 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 906
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    907 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 986
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350

                   ....*
gi 27262647    987 QVMLL 991
Cdd:pfam09770  351 QLAQL 355
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
123-196 1.64e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.64e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
264-326 1.56e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.56e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647    264 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 326
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
398-942 1.11e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   398 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNR--PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTS 474
Cdd:PHA03247 2456 ARTILGAPFSLSLLLGELFPGAPVYRRPAEArfPFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRM 2533
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   475 SASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFK 553
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGP 2611
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   554 LQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS------------------DKEDKPPLAPS 615
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPT 2691
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   616 GGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHST 692
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAP 2771
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   693 PSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaa 772
Cdd:PHA03247 2772 PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------ 2844
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   773 aagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2845 ----------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQP 2911
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   851 QALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PG 929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPA 2983
                         570
                  ....*....|...
gi 27262647   930 PSAQSPQSSFPQP 942
Cdd:PHA03247 2984 PSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
829-991 4.71e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 4.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    829 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 906
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    907 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 986
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350

                   ....*
gi 27262647    987 QVMLL 991
Cdd:pfam09770  351 QLAQL 355
PHA03247 PHA03247
large tegument protein UL36; Provisional
336-850 9.40e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   336 GRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGP-----------GSEARGINGG 404
Cdd:PHA03247 2513 SRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrpaprpsepavTSRARRPDAP 2592
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   405 PSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSV 484
Cdd:PHA03247 2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   485 SDPGVGSISPASPKISLAPTDVKELST----KEPGRTLEPQELARIAGKVPGLQNEQKRfqleelrkfgaqfklqpSSSP 560
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSladpPPPPPTPEPAPHALVSATPLPPGPAAAR-----------------QASP 2733
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   561 ENSLDPFPPrilkeePKGKEKEVDGllTSEPMGSPVSSKTESVSdkedKPPLAPSGGTEGPEQPPPPCPSQTGSPpvGLI 640
Cdd:PHA03247 2734 ALPAAPAPP------AVPAGPATPG--GPARPARPPTTAGPPAP----APPAAPAAGPPRRLTRPAVASLSESRE--SLP 2799
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   641 KGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPllsvnKSTSTPTSPGPRthSTPSIPVLTAGqsGLYSPQyisyipqihmG 720
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPP-----PTSAQPTAPPPP--PGPPPPSLPLG--GSVAPG----------G 2860
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   721 PAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQP- 799
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPq 2940
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27262647   800 AMMQPMAHYPSQPVFAPMLqSNPRM--LTSGSH--PQAIVSSSTPQYPSAEQPTP 850
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAV-PQPWLgaLVPGRVavPRFRVPQPAPSREAPASSTP 2994
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
652-916 1.34e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.26  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    652 EQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPrthSTPSIPVLTagqsGLYSPQYISYIPQIH-------MGPAVQ 724
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQS---QQPSKPVRT----GYEKYKEPEPIPDLQvdaslwgVAPKKA 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    725 APQMYPYPVSNSVPGQQGKYRG--------AKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFP 796
Cdd:pfam09770  171 AAPAPAPQPAAQPASLPAPSRKmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    797 GQPAMMQPMAHYPSQpvfapmLQsnpRMlTSGSHPQAIVSSSTPQYPSAEQPTPQalyatvhqsyPHHATQLHAHQPQPA 876
Cdd:pfam09770  251 QQPQQHPGQGHPVTI------LQ---RP-QSPQPDPAQPSIQPQAQQFHQQPPPV----------PVQPTQILQNPNRLS 310
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 27262647    877 TTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnLYHP 916
Cdd:pfam09770  311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
668-1037 4.00e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   668 PTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRG 746
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRA 2673
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   747 AKGSLPPQRSdqHQPASAPPMMQAAAAAGPPLVAATPYssyiPYNPQQFPGQPAMMQPMAHYPSQPVfAPMLQSNPRMLT 826
Cdd:PHA03247 2674 AQASSPPQRP--RRRAARPTVGSLTSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAVPA 2746
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   827 SGSHPQAIVSSSTPQYPSA-EQPTPQALYATVhqsyPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPhlG 905
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGpPAPAPPAAPAAG----PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP--P 2820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   906 SGQPQQNLYHPGALTGTPPSLPPGPSAQS------------------PQSSFPQPAAVYAIHHQQLPHGFTNMAHVTQAH 967
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   968 VQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAPG 1037
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
PRK10263 PRK10263
DNA translocase FtsK; Provisional
661-941 4.10e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   661 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 731
Cdd:PRK10263  302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   732 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 811
Cdd:PRK10263  381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   812 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 872
Cdd:PRK10263  454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27262647   873 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 941
Cdd:PRK10263  530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
791-1008 5.10e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 5.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    791 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPSAEQPTPQALYAT 856
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    857 VHQSYPHHAT------QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPP-- 928
Cdd:pfam09770  186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVti 265
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    929 --GPSAQSPQSSFPQPAAVYAIHHQQLPhgfTNMAHVTQA-------HVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGG 999
Cdd:pfam09770  266 lqRPQSPQPDPAQPSIQPQAQQFHQQPP---PVPVQPTQIlqnpnrlSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQ 342

                   ....*....
gi 27262647   1000 PPQGAVPQS 1008
Cdd:pfam09770  343 APIITHPQQ 351
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
374-696 9.45e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 9.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   374 PGLSSLPPRGPHHLDNSS----PGPGSEARGINGGPSRMSP----KAQRPLRGAKTLSSP--SNRPSGETSVPPPPavgR 443
Cdd:PTZ00449  514 PEASGLPPKAPGDKEGEEgeheDSKESDEPKEGGKPGETKEgevgKKPGPAKEHKPSKIPtlSKKPEFPKDPKHPK---D 590
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   444 MYPPRSPKS--AAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPgVGSISPASPKISLAPTDVKE-LSTKEPGRTLEP 520
Cdd:PTZ00449  591 PEEPKKPKRprSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRP-PPPQRPSSPERPEGPKIIKSpKPPKSPKPPFDP 669
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   521 ---QELARIAGKVPGLQNEQKRFQL--EELRKFGAQFKLQPSSSPENSLDPFPPRIlkeepkgkekEVDGLLTSEPMGSP 595
Cdd:PTZ00449  670 kfkEKFYDDYLDAAAKSKETKTTVVldESFESILKETLPETPGTPFTTPRPLPPKL----------PRDEEFPFEPIGDP 739
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   596 VSsktESVSDKE-DKPPLAPSggtegpeqpPPPCPSQTGSPPVGLIKGEDKDEGPVAEqvkksTLNPNAKEFNPTKPlls 674
Cdd:PTZ00449  740 DA---EQPDDIEfFTPPEEER---------TFFHETPADTPLPDILAEEFKEEDIHAE-----TGEPDEAMKRPDSP--- 799
                         330       340
                  ....*....|....*....|..
gi 27262647   675 vnkSTSTPTSPGprTHstPSIP 696
Cdd:PTZ00449  800 ---SEHEDKPPG--DH--PSLP 814
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
870-945 1.32e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27262647   870 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 945
Cdd:PRK14971  389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PRK10927 PRK10927
cell division protein FtsN;
841-944 4.59e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 43.52  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   841 QYPSAEQpTPQALYATVH-QSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGAL 919
Cdd:PRK10927  138 EVPWNEQ-TPEQRQQTLQrQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAH 216
                          90       100
                  ....*....|....*....|....*.
gi 27262647   920 TGTPPSLP-PGPSAQSPQSsfPQPAA 944
Cdd:PRK10927  217 TTAQSKPQqAAPVTRAADA--PKPTA 240
PRK10263 PRK10263
DNA translocase FtsK; Provisional
793-942 6.09e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   793 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAH 871
Cdd:PRK10263  709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27262647   872 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPgaltgTPPSLPPGPSAQSPQSSFPQP 942
Cdd:PRK10263  783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ-----PQYQQPQQPVAPQPQDTLLHP 848
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
658-916 8.00e-04

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 43.53  E-value: 8.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    658 TLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsv 737
Cdd:pfam03326  310 TLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADHQTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV----- 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    738 pgqqGKYRGAKGsLPPQRSDQHQPAsappmmQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapm 817
Cdd:pfam03326  383 ----GGKQFFQG-LRDSRSTSFLTA------PEATSAISDVFQGTEVCQPKRIRALHPPGSP------------------ 433
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    818 lqSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYAT--VHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQ 895
Cdd:pfam03326  434 --SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDAApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRG 511
                          250       260
                   ....*....|....*....|.
gi 27262647    896 HQAGQAPHLGSGQPQQNLYHP 916
Cdd:pfam03326  512 QLDELTTTLESMTEDLNLDSP 532
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
395-552 2.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.68  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   395 GSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPS-GETSVPPPPAvgrmypprspksaAPAPISASCPEPPIGSAVPT 473
Cdd:PRK14971  366 GDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSpSQSSAAAQPS-------------APQSATQPAGTPPTVSVDPP 432
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27262647   474 SSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRtlEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQF 552
Cdd:PRK14971  433 AAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQ--EKAEQATGNIKEAPTGTQKEIFTEEDLQYYWQEF 509
PHA03247 PHA03247
large tegument protein UL36; Provisional
332-532 2.90e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   332 RQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHH-------------LDNSSPGPGSEA 398
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRraarptvgsltslADPPPPPPTPEP 2710
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   399 RGINGGPSRMSPKAQRPLRGAK--TLSSPSNRPSGETSVPP-----------PPAVGRMYPPRSPKSAAP--APISASCP 463
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASpaLPAAPAPPAVPAGPATPggparparpptTAGPPAPAPPAAPAAGPPrrLTRPAVAS 2790
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27262647   464 EPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPG 532
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
359-528 3.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   359 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPS-NRPSGETSVPP 437
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPaTADRGDDAADG 445
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   438 PPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRT 517
Cdd:PRK07003  446 DAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAA 525
                         170
                  ....*....|.
gi 27262647   518 LEPQELARIAG 528
Cdd:PRK07003  526 APPAPEARPPT 536
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
394-555 5.59e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   394 PGSEARGINGGPSRMSPKAQRPLRGAKTLSSPsnRPSGETSVPPPPAVGRMYPPRSP-----KSAAPAPISASCPEPPIG 468
Cdd:PRK14951  374 APAEKKTPARPEAAAPAAAPVAQAAAAPAPAA--APAAAASAPAAPPAAAPPAPVAApaaaaPAAAPAAAPAAVALAPAP 451
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   469 SAVPTSSASIPVTSSVSDPGVGS----ISPASPKISLAPTD--------VKELSTKEPGRTLePQELAriagkvpgLQNE 536
Cdd:PRK14951  452 PAQAAPETVAIPVRVAPEPAVASaapaPAAAPAAARLTPTEegdvwhatVQQLAAAEAITAL-ARELA--------LQSE 522
                         170       180
                  ....*....|....*....|....*...
gi 27262647   537 ---------QKRFQLEELRKFGAQFKLQ 555
Cdd:PRK14951  523 lvardgdqwLLRVERESLNQPGARERLR 550
PHA03369 PHA03369
capsid maturational protease; Provisional
396-709 6.05e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 40.75  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   396 SEARGINGGPSRMSPKAQRPLRGAKTLSSPSnRPSGETSVPPPPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTss 475
Cdd:PHA03369  355 APSRVLAAAAKVAVIAAPQTHTGPADRQRPQ-RPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPE-- 431
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   476 asiPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEP--QELARIAGKVPGL--QNEQKRFQLEELRKFGAQ 551
Cdd:PHA03369  432 ---PVGPVPPQPTNPYVMPISMANMVYPGHPQEHGHERKRKRGGElkEELIETLKLVKKLkeEQESLAKELEATAHKSEI 508
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   552 fklqpSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQ 631
Cdd:PHA03369  509 -----KKIAESEFKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTLAAAA 583
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27262647   632 TGSPpvgliKGEDKDEGPVAEQVKKSTLNPnaKEFNPTKPLLSVNKSTSTPTSPgPRTHSTPSIPVLTAGQSGLYSPQ 709
Cdd:PHA03369  584 GQGS-----DTAEALAGAIETLLTQASAQP--AGLSLPAPAVPVNASTPASTPP-PLAPQEPPQPGTSAPSLETSLPQ 653
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
327-488 8.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   327 HSAVQRQGSGRESPSLASREGKyIPLPQRVREGPRGGVRcssSRGGRPGLSSLPPRGPHhldnSSPGPGSEARGINGGPS 406
Cdd:PHA03307  241 SSESSGCGWGPENECPLPRPAP-ITLPTRIWEASGWNGP---SSRPGPASSSSSPRERS----PSPSPSSPGSGPAPSSP 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647   407 RMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPRSPKS-AAPAPISASCPEPPIGSAVPTSSASIPVTSSVS 485
Cdd:PHA03307  313 RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPpADPSSPRKRPRPSRAPSSPAASAGRPTRRRARA 392

                  ...
gi 27262647   486 DPG 488
Cdd:PHA03307  393 AVA 395
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
668-945 9.52e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    668 PTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIsyiPQIHmGPAVQAPQMYPYPVSNSVPGQQGKYRGA 747
Cdd:pfam03154  199 PTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPH-PPLQPMTQPPPPSQVSPQPLPQPSLHGQ 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    748 KGSLPP--QRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM------QPMAHYPSQPVFAPMLQ 819
Cdd:pfam03154  275 MPPMPHslQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQsqlqsqQPPREQPLPPAPLSMPH 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262647    820 SNPRMLT---------SGSHPQAIVSSSTPQYPSAEQPTPQ----ALYATVHQSYPHHATQLHAHQPQPATTPTGSQP-- 884
Cdd:pfam03154  355 IKPPPTTpipqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPAlkplSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvl 434
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27262647    885 -QSQHAAPSPVQHQAGQAPHLGSGQ---PQQNLYHPGALTGTPPSLPPG-----------PSAQSPQSSFPQPAAV 945
Cdd:pfam03154  435 tQSQSLPPPAASHPPTSGLHQVPSQspfPQHPFVPGGPPPITPPSGPPTstssampgiqpPSSASVSSSGPVPAAV 510
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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