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Conserved domains on  [gi|37362625|ref|NP_009893|]
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Sro9p [Saccharomyces cerevisiae S288C]

Protein Classification

LHP1 family protein( domain architecture ID 11474125)

LHP1 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 1-434 1.25e-128

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 378.62  E-value: 1.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625   1 MSAETAAANTATAPVPEVQEQESSKSKQVNLTPAPLPTSSPWKLAPTEIPVSTISIEDLDATRKKKNRTPTPKSSTATKW 80
Cdd:COG5193  33 TSEEKSKSQDSNTVIPVEELTESSKSKKEDKNPSKLTSNTKWTLKQVEFYFSGSKDTDSNFPKDKFLKTTAPKNKKRDKW 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625  81 VPIKASITVSGTKRSGSKNGASNGNSNKSKNNKTAASSTSSSNANRKKKHHQHNAKKQQQMKKDGFESAVGEEDSKDATS 160
Cdd:COG5193 113 VPIKTIATFNRMKNSGSPVSAVSGALRKSLDARVLEVSSSGSNKNRTEKLISNNNKSTSQMQRDVYQNGFGKEDVNNASR 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 161 QENGQSTQQQQPPhhrnhhHSHHHNSNGPQRRKFHNSNNAGMpqnqgFPPQFKPYQGRNARNNNNNRSKyhnhfhhnqqh 240
Cdd:COG5193 193 PEQQEDLEIQFPP------HYHAPPSQIRNRRDWLNKNFRGS-----VFVEFKYFREAQRFNNGFYRNK----------- 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 241 pQQPMVKLQQQFYPVQPVLMAINNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRvvNMSFGGDTNLILAA 320
Cdd:COG5193 251 -KYPNDPETVYYYSVEPILLSIMAKKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYR--NLSFGGDKNLILAA 327

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 321 LREIVANEAATVNvaeGTLAAKEGDNVTGEAKEPSPLDKYFVRSKSWSNWLPETFETEINIEKELVGDALDQFMISLPPV 400
Cdd:COG5193 328 MKEVVQNKATNHL---EIALGSIEDAQKNEAKDFSPGKKYFIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPY 404

                       410       420       430
                ....*....|....*....|....*....|....
gi 37362625 401 PQQEEESSTELASQEQETKEDSAPVAAGESESSL 434
Cdd:COG5193 405 SYMGYPNFFPSNENGKKSQSYDQGEISREFEQNL 438
 
Name Accession Description Interval E-value
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 1-434 1.25e-128

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 378.62  E-value: 1.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625   1 MSAETAAANTATAPVPEVQEQESSKSKQVNLTPAPLPTSSPWKLAPTEIPVSTISIEDLDATRKKKNRTPTPKSSTATKW 80
Cdd:COG5193  33 TSEEKSKSQDSNTVIPVEELTESSKSKKEDKNPSKLTSNTKWTLKQVEFYFSGSKDTDSNFPKDKFLKTTAPKNKKRDKW 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625  81 VPIKASITVSGTKRSGSKNGASNGNSNKSKNNKTAASSTSSSNANRKKKHHQHNAKKQQQMKKDGFESAVGEEDSKDATS 160
Cdd:COG5193 113 VPIKTIATFNRMKNSGSPVSAVSGALRKSLDARVLEVSSSGSNKNRTEKLISNNNKSTSQMQRDVYQNGFGKEDVNNASR 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 161 QENGQSTQQQQPPhhrnhhHSHHHNSNGPQRRKFHNSNNAGMpqnqgFPPQFKPYQGRNARNNNNNRSKyhnhfhhnqqh 240
Cdd:COG5193 193 PEQQEDLEIQFPP------HYHAPPSQIRNRRDWLNKNFRGS-----VFVEFKYFREAQRFNNGFYRNK----------- 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 241 pQQPMVKLQQQFYPVQPVLMAINNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRvvNMSFGGDTNLILAA 320
Cdd:COG5193 251 -KYPNDPETVYYYSVEPILLSIMAKKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYR--NLSFGGDKNLILAA 327

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 321 LREIVANEAATVNvaeGTLAAKEGDNVTGEAKEPSPLDKYFVRSKSWSNWLPETFETEINIEKELVGDALDQFMISLPPV 400
Cdd:COG5193 328 MKEVVQNKATNHL---EIALGSIEDAQKNEAKDFSPGKKYFIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPY 404

                       410       420       430
                ....*....|....*....|....*....|....
gi 37362625 401 PQQEEESSTELASQEQETKEDSAPVAAGESESSL 434
Cdd:COG5193 405 SYMGYPNFFPSNENGKKSQSYDQGEISREFEQNL 438
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
260-344 2.10e-22

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 90.37  E-value: 2.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625    260 MAINNIARQIEYYFSEENLTVDNYLRSKLSK-DGFAPLSLISKFYRVVNMSFggDTNLILAALREIvaneaATVNVAEGT 338
Cdd:smart00715   2 ELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTT--DVNLIVEALRSS-----PKLEVSEDG 74


                   ....*.
gi 37362625    339 LAAKEG 344
Cdd:smart00715  75 LKVRRR 80
LAM cd07323
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 262-323 2.01e-21

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153396  Cd Length: 75  Bit Score: 87.59  E-value: 2.01e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37362625 262 INNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSFGGdtNLILAALRE 323
Cdd:cd07323   1 LEKIKKQVEYYFSDENLCKDRFLRSLMDDDGWVPLSLLASFNRVKKLTTDV--ELILEALRD 60
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 265-323 1.56e-19

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 81.70  E-value: 1.56e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37362625   265 IARQIEYYFSEENLTVDNYLRSKLSK--DGFAPLSLISKFYRVVNMSFggDTNLILAALRE 323
Cdd:pfam05383   1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTT--DIDLIAEALRE 59
 
Name Accession Description Interval E-value
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 1-434 1.25e-128

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 378.62  E-value: 1.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625   1 MSAETAAANTATAPVPEVQEQESSKSKQVNLTPAPLPTSSPWKLAPTEIPVSTISIEDLDATRKKKNRTPTPKSSTATKW 80
Cdd:COG5193  33 TSEEKSKSQDSNTVIPVEELTESSKSKKEDKNPSKLTSNTKWTLKQVEFYFSGSKDTDSNFPKDKFLKTTAPKNKKRDKW 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625  81 VPIKASITVSGTKRSGSKNGASNGNSNKSKNNKTAASSTSSSNANRKKKHHQHNAKKQQQMKKDGFESAVGEEDSKDATS 160
Cdd:COG5193 113 VPIKTIATFNRMKNSGSPVSAVSGALRKSLDARVLEVSSSGSNKNRTEKLISNNNKSTSQMQRDVYQNGFGKEDVNNASR 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 161 QENGQSTQQQQPPhhrnhhHSHHHNSNGPQRRKFHNSNNAGMpqnqgFPPQFKPYQGRNARNNNNNRSKyhnhfhhnqqh 240
Cdd:COG5193 193 PEQQEDLEIQFPP------HYHAPPSQIRNRRDWLNKNFRGS-----VFVEFKYFREAQRFNNGFYRNK----------- 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 241 pQQPMVKLQQQFYPVQPVLMAINNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRvvNMSFGGDTNLILAA 320
Cdd:COG5193 251 -KYPNDPETVYYYSVEPILLSIMAKKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYR--NLSFGGDKNLILAA 327

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 321 LREIVANEAATVNvaeGTLAAKEGDNVTGEAKEPSPLDKYFVRSKSWSNWLPETFETEINIEKELVGDALDQFMISLPPV 400
Cdd:COG5193 328 MKEVVQNKATNHL---EIALGSIEDAQKNEAKDFSPGKKYFIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPY 404

                       410       420       430
                ....*....|....*....|....*....|....
gi 37362625 401 PQQEEESSTELASQEQETKEDSAPVAAGESESSL 434
Cdd:COG5193 405 SYMGYPNFFPSNENGKKSQSYDQGEISREFEQNL 438
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
260-344 2.10e-22

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 90.37  E-value: 2.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625    260 MAINNIARQIEYYFSEENLTVDNYLRSKLSK-DGFAPLSLISKFYRVVNMSFggDTNLILAALREIvaneaATVNVAEGT 338
Cdd:smart00715   2 ELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTT--DVNLIVEALRSS-----PKLEVSEDG 74


                   ....*.
gi 37362625    339 LAAKEG 344
Cdd:smart00715  75 LKVRRR 80
LAM cd07323
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 262-323 2.01e-21

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153396  Cd Length: 75  Bit Score: 87.59  E-value: 2.01e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37362625 262 INNIARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSFGGdtNLILAALRE 323
Cdd:cd07323   1 LEKIKKQVEYYFSDENLCKDRFLRSLMDDDGWVPLSLLASFNRVKKLTTDV--ELILEALRD 60
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 265-323 1.56e-19

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 81.70  E-value: 1.56e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37362625   265 IARQIEYYFSEENLTVDNYLRSKLSK--DGFAPLSLISKFYRVVNMSFggDTNLILAALRE 323
Cdd:pfam05383   1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTT--DIDLIAEALRE 59
LARP_1_2 cd08034
La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in ...
 265-323 1.07e-16

La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in proteins similar to vertebrate La-related proteins 1 and 2 (LARP1, LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153403  Cd Length: 73  Bit Score: 74.39  E-value: 1.07e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVvnMSFGGDTNLILAALRE 323
Cdd:cd08034   4 IKKQIEYYFSVDNLEKDFFLRRKMDPEGYLPIALIASFHRV--QALTTDVNLILEALKD 60
LARP_2 cd08038
La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related ...
 265-328 3.42e-14

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153407  Cd Length: 73  Bit Score: 67.28  E-value: 3.42e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVvnMSFGGDTNLILAALREIVANE 328
Cdd:cd08038   4 IKRQIEYYFSTENLERDFFLRRKMDLQGFLPISLIAGFYRV--QALTTNVDLILEALKDSTEVE 65
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 265-323 2.53e-13

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 64.92  E-value: 2.53e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSfgGDTNLILAALRE 323
Cdd:cd08037   4 IKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALT--TDISLIIKALKD 60
LARP_4_5_like cd08031
La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found ...
 265-323 2.50e-10

La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found in proteins similar to La-related proteins 4 and 5 (LARP4, LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153400  Cd Length: 75  Bit Score: 56.29  E-value: 2.50e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSfgGDTNLILAALRE 323
Cdd:cd08031   4 LKRQLEYYFSRENLANDAYLLSQMDSDQYVPIWTIANFNKIKKLT--TDIDLIVEALRE 60
LARP_3 cd08028
La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the ...
 265-323 1.10e-09

La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the La autoantigen and similar proteins, and co-occurs with an RNA-recognition motif (RRM). Together these domains function to bind primary transcripts of RNA polymerase III at their 3' terminus and protect them from exonucleolytic degradation. Binding is specific for the 3'-terminal UUU-OH motif. The La autoantigen is also called Lupus La protein, LARP3, or Sjoegren syndrome type B antigen (SS-B).


Pssm-ID: 153397  Cd Length: 82  Bit Score: 54.61  E-value: 1.10e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSK-DGFAPLSLISKFYRVVNMSfgGDTNLILAALRE 323
Cdd:cd08028   8 IIRQIEYYFGDFNLPRDKFLKEQIKEdDGWVPMEVMLKFNRLKSLS--SDPEVIAKALKK 65
LARP_6 cd08033
La RNA-binding domain of La-related protein 6; This domain is found in animal and plant ...
 262-328 3.56e-09

La RNA-binding domain of La-related protein 6; This domain is found in animal and plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153402  Cd Length: 77  Bit Score: 53.06  E-value: 3.56e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37362625 262 INNIARQIEYYFSEENLTVDNYLRSKLSKD--GFAPLSLISKFYRVVNMSfgGDTNLILAALRE---IVANE 328
Cdd:cd08033   1 IQKIVKQVEYYFSDENLLKDAFLLKHVRRNkeGYVPIKLIASFKKVKALT--RDWRVVAAALRRsskLVVSE 70
LA_like_fungal cd08029
La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in ...
 265-323 8.53e-07

La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in fungal proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153398  Cd Length: 76  Bit Score: 46.53  E-value: 8.53e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKL--SKDGFAPLSLISKFYRvvnMSFGGDTNLILAALRE 323
Cdd:cd08029   4 IRKQVEFYFSDSNLPTDKFLWTLTggSNNGWVPIKTIASFKR---MRRFQPLEAVVEALRE 61
LA_like_plant cd08030
La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant ...
 265-327 8.94e-07

La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153399  Cd Length: 90  Bit Score: 46.61  E-value: 8.94e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKL--SKDGFAPLSLISKFYRVVNM--SFGGDTNLILAALREIVAN 327
Cdd:cd08030   5 VLRQVEFYFSDSNLPRDDFLLEEVeeDPDGMVSLALICSFSRMRSLlgLGGGKPEDVPEDTLKAVAE 71
LARP_7 cd08032
La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key ...
 258-322 4.35e-06

La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.


Pssm-ID: 153401  Cd Length: 82  Bit Score: 44.55  E-value: 4.35e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 37362625 258 VLMAINNIARQIEYYFSEENLTVDNYLRSKL--SKDGFAPLSLISKFYRVVNMSfgGDTNLILAALR 322
Cdd:cd08032   2 VKQLLADIAKQVDFWFGDVNLHKDRFLREQIekSRDGYIDISLLVSFNKMKKLT--TDGKLIARALK 66
LARP_4 cd08035
La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related ...
 265-322 3.95e-05

La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related protein 4 (LARP4), also known as c-MPL binding protein. La-type domains often co-occur with RNA-recognition motifs (RRMs). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153404  Cd Length: 75  Bit Score: 41.57  E-value: 3.95e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 37362625 265 IARQIEYYFSEENLTVDNYLRSKLSKDGFAPLSLISKFYRVVNMSfgGDTNLILAALR 322
Cdd:cd08035   4 LKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEGIKKLT--TDMDLILDVLR 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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