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Conserved domains on  [gi|6320091|ref|NP_010171|]
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tRNA (guanosine(18)-2'-O)-methyltransferase [Saccharomyces cerevisiae S288C]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 13031009)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047|GO:0003723|GO:0032259
PubMed:  11763972|17338813|30457841|18029778

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1286-1431 1.03e-70

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


:

Pssm-ID: 349964  Cd Length: 145  Bit Score: 232.81  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGL 1365
Cdd:cd18091    1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320091  1366 EQTDKSVKLdNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSY 1431
Cdd:cd18091   81 EQTANSVSL-HDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
 
Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1286-1431 1.03e-70

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 232.81  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGL 1365
Cdd:cd18091    1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320091  1366 EQTDKSVKLdNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSY 1431
Cdd:cd18091   81 EQTANSVSL-HDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1285-1429 9.52e-26

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 104.15  E-value: 9.52e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091    1285 ELIVVSSLVDKPPNLGGICRLCDVLGV-GLLTVQDIKVK-NHPQFKNVAVTADRWMPMEEValDEIASFMKEKKKEGYTL 1362
Cdd:pfam00588    1 PLVVVLDNIQDPGNLGAIIRTAAAFGAdGLILVEPRSADpYNPKAIRASAGALFHLPLVVV--DNLEEALKDLKEAGYAV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320091    1363 IGLEQTDKSVkldNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVH 1429
Cdd:pfam00588   79 VATSLGGKSL---YEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
PRK10864 PRK10864
putative methyltransferase; Provisional
 1293-1435 2.09e-07

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 54.78  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091   1293 VDKPPNLGGICRLCDVLGVGLLTVQDIKVKNhpqfKNVAV-TADRWMP-MEEVALDEIASFMKEKKKEGYTLIgleqTDK 1370
Cdd:PRK10864  206 VGNPHNLGGIMRSCAHFGVKGVVVQDAALLE----SGAAIrTAEGGAEhVQPITGDSFVDVLDDFRQAGYTIV----TTS 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320091   1371 SVKLDNNFQ--FPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQH 1435
Cdd:PRK10864  278 SHKGTPLFKasLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQN 344
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 1286-1429 4.04e-07

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 53.28  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDkPPNLGGICRLCDVLGV-GLLTVQDikvknhpqfknvavTADRW--------------MPMEEVAldEIAS 1350
Cdd:COG0566  117 LLVLDGVQD-PGNLGAILRSAAAFGVdGVILPKR--------------RADPYnpkvvrasagalfhVPVARVT--NLAD 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1351 FMKEKKKEGYTLIGL-EQTDKSVKldnNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVH 1429
Cdd:COG0566  180 ALEELKEAGFWVVGTdLDGEASLY---EVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256
 
Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1286-1431 1.03e-70

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 232.81  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGL 1365
Cdd:cd18091    1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320091  1366 EQTDKSVKLdNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSY 1431
Cdd:cd18091   81 EQTANSVSL-HDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1285-1429 9.52e-26

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 104.15  E-value: 9.52e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091    1285 ELIVVSSLVDKPPNLGGICRLCDVLGV-GLLTVQDIKVK-NHPQFKNVAVTADRWMPMEEValDEIASFMKEKKKEGYTL 1362
Cdd:pfam00588    1 PLVVVLDNIQDPGNLGAIIRTAAAFGAdGLILVEPRSADpYNPKAIRASAGALFHLPLVVV--DNLEEALKDLKEAGYAV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320091    1363 IGLEQTDKSVkldNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVH 1429
Cdd:pfam00588   79 VATSLGGKSL---YEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1287-1429 8.81e-23

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 95.76  E-value: 8.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1287 IVVSSLVDKPPNLGGICRLCDVLGV-GLLTVQDIKVKNHPQFKNVAVTADRWMPMEEValDEIASFMKEKKKEGYTLIGL 1365
Cdd:cd18082    1 HLVLDNIRSPGNIGSIFRTADAFGVeKIYLVGPTADIFDPKAKRTSRGTHFSVPYERV--DNFEEYLKSLKEEGYPLIGL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320091  1366 EQTDKSVKLDN-NFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVH 1429
Cdd:cd18082   79 ELTDGSIPLSEfKFKKPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALY 143
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1298-1427 2.36e-18

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 83.00  E-value: 2.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1298 NLGGICRLCDVLGVG-LLTVQDIKVKNHPQFKNVAVTADRWMPMEEV--ALDEIasfmKEKKKEGYTLIGLEQTDKSVKL 1374
Cdd:cd18097   13 NVGSIFRTADAAGVEkIYLCGYTPTPPHPKVAKTALGAEESVPWEHFedTLEAV----RALKARGYTIIALETTENSVPL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6320091  1375 dNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVI 1427
Cdd:cd18097   89 -HEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVA 140
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 1286-1434 3.44e-14

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 71.73  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDKPPNLGGICRLCDVLGVglltvQDIKV----KNHPQFKNVAVTADRWMPMEEValDEIASFMKEKKKEGYT 1361
Cdd:cd18092   17 LTVVLENVHDPHNASAVLRTCDAFGV-----QDVHViepkNKFKKNRGVAMGADKWLDVHRH--DSTEECLAALKEQGYR 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320091  1362 LIGLEQTDKSVKLDNnFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQ 1434
Cdd:cd18092   90 IVATSLSPDAVPLDE-LDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQRQ 161
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 1286-1434 5.64e-10

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 59.13  E-value: 5.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVK-NHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKkegYTLIG 1364
Cdd:cd18104    1 LILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDlFNPNVIRASLGAVFTLPVAEASSEETLAWLKENK---IRILA 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1365 leQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQ 1434
Cdd:cd18104   78 --TTPKAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALRQ 145
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 1286-1427 1.24e-07

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 52.39  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDkPPNLGGICRLCDVLGVglltvqdikvknhpqfKNVAVTADRWMPMEEVAL---------------DEIAS 1350
Cdd:cd18103    2 LLILDGITD-PHNLGAIIRSAEAFGV----------------DGVIIPKRRSAPLTPTVAkasagalehlpiarvTNLAR 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320091  1351 FMKEKKKEGYTLIGLEQTDKsvKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVI 1427
Cdd:cd18103   65 ALEELKEAGFWIYGADGEAE--KSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGII 139
PRK10864 PRK10864
putative methyltransferase; Provisional
 1293-1435 2.09e-07

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 54.78  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091   1293 VDKPPNLGGICRLCDVLGVGLLTVQDIKVKNhpqfKNVAV-TADRWMP-MEEVALDEIASFMKEKKKEGYTLIgleqTDK 1370
Cdd:PRK10864  206 VGNPHNLGGIMRSCAHFGVKGVVVQDAALLE----SGAAIrTAEGGAEhVQPITGDSFVDVLDDFRQAGYTIV----TTS 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320091   1371 SVKLDNNFQ--FPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQH 1435
Cdd:PRK10864  278 SHKGTPLFKasLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQN 344
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 1286-1429 4.04e-07

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 53.28  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1286 LIVVSSLVDkPPNLGGICRLCDVLGV-GLLTVQDikvknhpqfknvavTADRW--------------MPMEEVAldEIAS 1350
Cdd:COG0566  117 LLVLDGVQD-PGNLGAILRSAAAFGVdGVILPKR--------------RADPYnpkvvrasagalfhVPVARVT--NLAD 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1351 FMKEKKKEGYTLIGL-EQTDKSVKldnNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVH 1429
Cdd:COG0566  180 ALEELKEAGFWVVGTdLDGEASLY---EVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLY 256
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 1296-1427 3.81e-05

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 45.22  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320091  1296 PPNLGGICRLCDVLGVG-LLTVQDikvknhpqfknvavTADRWMP------ME-----EVALDEIASFMKEKKKEgYTLI 1363
Cdd:cd18109   11 PGNLGTIIRTADWFGIRqIICSPD--------------TVDPYNPkvvqasMGsifrvQIHYTDLPALLAELKKA-FPVY 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320091  1364 GLEQTDKSVkldNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVI-RSMNIQTATAVI 1427
Cdd:cd18109   76 GADLDGENL---YEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGKGaESLNVAVATAIL 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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