NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6322590|ref|NP_012664|]
View 

cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

Protein Classification

PLP-dependent aspartate aminotransferase family protein( domain architecture ID 10001832)

PLP-dependent aspartate aminotransferase family protein similar to cystathionine gamma-synthase (EC 2.5.1.48) and cystathionine beta-lyase (EC 4.4.1.8)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MetC super family cl43216
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 290-636 1.04e-23

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


The actual alignment was detected with superfamily member COG0626:

Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 103.59  E-value: 1.04e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  290 NPNTDV--------------YLFPSGMASIFTAHRLLLnfdakrlsrssSRQDKLI----GYGPpfkktvmfgfpyTDTL 351
Cdd:COG0626  57 NPTRRAleealaaleggeaaLAFASGMAAISAVLLALL-----------KAGDHVVasddLYGG------------TRRL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  352 --SILRKFN--HTHFlgqgDSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGfvn 427
Cdd:COG0626 114 ldKVLARFGieVTFV----DPTDLAAVEAAI--RPNTKLVFLETPSNPTLEVVDIAAIAAIAHAAGALLVVDNTFAT--- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  428 idvlPY--------ADIVCSSLTKIFSGDSNVIAGSLVLNP---RGKIYEFARKF---------------MKTedgyedc 481
Cdd:COG0626 185 ----PLlqrplelgADIVVHSATKYLGGHSDVLGGAVVGRDeelAERLRFLQNALgavlspfdawlllrgLKT------- 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  482 LwcedALCLER---NSRDFVERtikvntntdiLLKRvllPQVgklfKKIYYPSLTS----EDTKRnydsVMStkdgGYGG 554
Cdd:COG0626 254 L----ALRMERhceNALAVAEW----------LEAH---PAV----ARVYYPGLPShpghELAKR----QMS----GFGG 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  555 LFSLTFF-NIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQ-ELDEVAQYGVETNLVRVSVGLENSDVLCNVFQR 631
Cdd:COG0626 305 MLSFELKgGREAARRFLDALKLFTlAVSLGGVESLITHPATMTHRSlPPEERAALGITDGLVRLSVGLEDVDDLIADLEQ 384


                ....*
gi 6322590  632 AIEKA 636
Cdd:COG0626 385 ALAAL 389
 
Name Accession Description Interval E-value
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 290-636 1.04e-23

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 103.59  E-value: 1.04e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  290 NPNTDV--------------YLFPSGMASIFTAHRLLLnfdakrlsrssSRQDKLI----GYGPpfkktvmfgfpyTDTL 351
Cdd:COG0626  57 NPTRRAleealaaleggeaaLAFASGMAAISAVLLALL-----------KAGDHVVasddLYGG------------TRRL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  352 --SILRKFN--HTHFlgqgDSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGfvn 427
Cdd:COG0626 114 ldKVLARFGieVTFV----DPTDLAAVEAAI--RPNTKLVFLETPSNPTLEVVDIAAIAAIAHAAGALLVVDNTFAT--- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  428 idvlPY--------ADIVCSSLTKIFSGDSNVIAGSLVLNP---RGKIYEFARKF---------------MKTedgyedc 481
Cdd:COG0626 185 ----PLlqrplelgADIVVHSATKYLGGHSDVLGGAVVGRDeelAERLRFLQNALgavlspfdawlllrgLKT------- 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  482 LwcedALCLER---NSRDFVERtikvntntdiLLKRvllPQVgklfKKIYYPSLTS----EDTKRnydsVMStkdgGYGG 554
Cdd:COG0626 254 L----ALRMERhceNALAVAEW----------LEAH---PAV----ARVYYPGLPShpghELAKR----QMS----GFGG 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  555 LFSLTFF-NIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQ-ELDEVAQYGVETNLVRVSVGLENSDVLCNVFQR 631
Cdd:COG0626 305 MLSFELKgGREAARRFLDALKLFTlAVSLGGVESLITHPATMTHRSlPPEERAALGITDGLVRLSVGLEDVDDLIADLEQ 384


                ....*
gi 6322590  632 AIEKA 636
Cdd:COG0626 385 ALAAL 389
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 290-634 2.56e-22

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 99.20  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  290 NPNTDV--------------YLFPSGMASIFTAHRLLLnfdakrlsrsssrqdkligygPPFKKTVMFGFPYTDTLSILR 355
Cdd:cd00614  39 NPTVDAlekklaaleggeaaLAFSSGMAAISTVLLALL---------------------KAGDHVVASDDLYGGTYRLFE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  356 KFNH-----THFLGQGDstsMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDV 430
Cdd:cd00614  98 RLLPklgieVTFVDPDD---PEALEAAI--KPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  431 LPY-ADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTedGYedCLWCEDALCLERNSRDFVERTIKVNTNTD 509
Cdd:cd00614 173 LELgADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLAL--GT--ILSPFDAWLLLRGLKTLPLRMERHSENAL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  510 ILLKRVL-LPQVgklfKKIYYPSLTSEDTKRNYDSVMStkdgGYGGLFSltfFNI----EEAKKFFNNLELCK-GPSLGT 583
Cdd:cd00614 249 KVAEFLEkHPKV----ERVYYPGLPSHPQHELAKKQMS----GYGGVFS---FELkgglEAAKKFLNALKLFSlAVSLGG 317

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 6322590  584 NFTLACPYAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:cd00614 318 VESLVEHPASMTHSQLPPEErAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
PRK06176 PRK06176
cystathionine gamma-synthase;
386-635 1.69e-17

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 84.95  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   386 AVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGG-FVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRgki 464
Cdd:PRK06176 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATpYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNE--- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   465 yEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTdilLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSV 544
Cdd:PRK06176 214 -ALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNA---LCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQ 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   545 MStkdgGYGGLFSLTFFNIEEAKKFFNNLEL-CKGPSLGTNFTLACPYAIIAHY---QELDEVAqyGVETNLVRVSVGLE 620
Cdd:PRK06176 290 MR----GFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFMTHAcipKEQREAA--GIRDGLVRLSVGIE 363

                        250
                 ....*....|....*
gi 6322590   621 NSDVLCNVFQRAIEK 635
Cdd:PRK06176 364 HEQDLLEDLEQAFAK 378
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 290-634 9.82e-17

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 82.28  E-value: 9.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    290 NPNTDV--------------YLFPSGMASIFTAHRLLLNFDAKRLSRSSSrqdkligYGPPFkktVMFGFpytdtlsILR 355
Cdd:pfam01053  46 NPTRDVleeriaaleggaaaLAFSSGMAAITAAILALLKAGDHIVATDDL-------YGGTY---RLFNK-------VLP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    356 KFN-HTHFLgqgDSTSMNALKNilHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY- 433
Cdd:pfam01053 109 RFGiEVTFV---DTSDPEDLEA--AIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLg 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    434 ADIVCSSLTKIFSGDSNVIAGSLVLNpRGKIYEFARKFMKTEDGyedCLWCEDALCLERNSRDFVERTIKVNTNTDILLK 513
Cdd:pfam01053 184 ADIVVHSATKYIGGHSDVVGGVIVVN-GEELGKELYFLQNATGA---VLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    514 rvLL---PQVgklfKKIYYPSLTSEDTKRNYDSVMStkdgGYGGLFSltfFNI----EEAKKFFNNLEL-CKGPSLG-TN 584
Cdd:pfam01053 260 --FLeshPKV----EKVYYPGLPSHPGHELAKRQMK----GFGGMLS---FELkgglEAAKKFLDNLKLfSLAVSLGgVE 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6322590    585 FTLACPyAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:pfam01053 327 SLISHP-ATMTHASIPPEErEAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 367-636 1.98e-08

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 56.76  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    367 DSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIF 445
Cdd:TIGR01329 117 DTTDLDKVKAAL--GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELgADIVYHSATKFL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    446 SGDSNVIAGSLVLNPRgkiyEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILlkrVLLPQVGKLFK 525
Cdd:TIGR01329 195 AGHSDVMAGVLAVKGE----EIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAI---AMFLSTHPRVK 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    526 KIYYPSLTSEDtkrNYDSVMSTKDGGyGGLFSLTFFNIEEAKKFfnnLELCKGPSLGTNF-------TLACPYAIIAHYQ 598
Cdd:TIGR01329 268 KVRYAGLPSHP---GFHLHFSQAKGA-GSVLSFETGSVALSKRL---VEATKLFSITVSFgsvnsliSMPCFMSHASIPA 340

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 6322590    599 ELDEVAQYGVEtnLVRVSVGLENSDVLCNVFQRAIEKA 636
Cdd:TIGR01329 341 EVREERGLPED--LVRLSVGIEDVDDLISDLDIAFVTA 376
 
Name Accession Description Interval E-value
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 290-636 1.04e-23

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 103.59  E-value: 1.04e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  290 NPNTDV--------------YLFPSGMASIFTAHRLLLnfdakrlsrssSRQDKLI----GYGPpfkktvmfgfpyTDTL 351
Cdd:COG0626  57 NPTRRAleealaaleggeaaLAFASGMAAISAVLLALL-----------KAGDHVVasddLYGG------------TRRL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  352 --SILRKFN--HTHFlgqgDSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGfvn 427
Cdd:COG0626 114 ldKVLARFGieVTFV----DPTDLAAVEAAI--RPNTKLVFLETPSNPTLEVVDIAAIAAIAHAAGALLVVDNTFAT--- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  428 idvlPY--------ADIVCSSLTKIFSGDSNVIAGSLVLNP---RGKIYEFARKF---------------MKTedgyedc 481
Cdd:COG0626 185 ----PLlqrplelgADIVVHSATKYLGGHSDVLGGAVVGRDeelAERLRFLQNALgavlspfdawlllrgLKT------- 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  482 LwcedALCLER---NSRDFVERtikvntntdiLLKRvllPQVgklfKKIYYPSLTS----EDTKRnydsVMStkdgGYGG 554
Cdd:COG0626 254 L----ALRMERhceNALAVAEW----------LEAH---PAV----ARVYYPGLPShpghELAKR----QMS----GFGG 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  555 LFSLTFF-NIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQ-ELDEVAQYGVETNLVRVSVGLENSDVLCNVFQR 631
Cdd:COG0626 305 MLSFELKgGREAARRFLDALKLFTlAVSLGGVESLITHPATMTHRSlPPEERAALGITDGLVRLSVGLEDVDDLIADLEQ 384


                ....*
gi 6322590  632 AIEKA 636
Cdd:COG0626 385 ALAAL 389
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 290-634 2.56e-22

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 99.20  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  290 NPNTDV--------------YLFPSGMASIFTAHRLLLnfdakrlsrsssrqdkligygPPFKKTVMFGFPYTDTLSILR 355
Cdd:cd00614  39 NPTVDAlekklaaleggeaaLAFSSGMAAISTVLLALL---------------------KAGDHVVASDDLYGGTYRLFE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  356 KFNH-----THFLGQGDstsMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDV 430
Cdd:cd00614  98 RLLPklgieVTFVDPDD---PEALEAAI--KPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  431 LPY-ADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTedGYedCLWCEDALCLERNSRDFVERTIKVNTNTD 509
Cdd:cd00614 173 LELgADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLAL--GT--ILSPFDAWLLLRGLKTLPLRMERHSENAL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590  510 ILLKRVL-LPQVgklfKKIYYPSLTSEDTKRNYDSVMStkdgGYGGLFSltfFNI----EEAKKFFNNLELCK-GPSLGT 583
Cdd:cd00614 249 KVAEFLEkHPKV----ERVYYPGLPSHPQHELAKKQMS----GYGGVFS---FELkgglEAAKKFLNALKLFSlAVSLGG 317

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 6322590  584 NFTLACPYAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:cd00614 318 VESLVEHPASMTHSQLPPEErAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
PRK06176 PRK06176
cystathionine gamma-synthase;
386-635 1.69e-17

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 84.95  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   386 AVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGG-FVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRgki 464
Cdd:PRK06176 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATpYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNE--- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   465 yEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTdilLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSV 544
Cdd:PRK06176 214 -ALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNA---LCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQ 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   545 MStkdgGYGGLFSLTFFNIEEAKKFFNNLEL-CKGPSLGTNFTLACPYAIIAHY---QELDEVAqyGVETNLVRVSVGLE 620
Cdd:PRK06176 290 MR----GFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFMTHAcipKEQREAA--GIRDGLVRLSVGIE 363

                        250
                 ....*....|....*
gi 6322590   621 NSDVLCNVFQRAIEK 635
Cdd:PRK06176 364 HEQDLLEDLEQAFAK 378
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
293-634 1.83e-17

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 84.73  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   293 TDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSsrqdkliGYGPPFKktvmfgfpytdTLSILRKFNHTHFLGQGDSTSMN 372
Cdd:PRK08574  69 VDALAFNSGMAAISTLFFSLLKAGDRVVLPME-------AYGTTLR-----------LLKSLEKFGVKVVLAYPSTEDII 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   373 alkNILHSGEQILaVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNV 451
Cdd:PRK08574 131 ---EAIKEGRTKL-VFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTFATPLLYRPLRHgADFVVHSLTKYIAGHNDV 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   452 IAGSLVLNPRGKIYEFA--RKFMKTedgyedCLWCEDALCLERNSRDFVERTIKVNTNTDILLKrvLLPQVGKLfKKIYY 529
Cdd:PRK08574 207 VGGVAVAWSGEFLEELWewRRRLGT------IMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAE--FLSEHPKV-AEVYY 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   530 PSLTSEDtkrnYDSVMST--KDGGYGGLFSltfFNI----EEAKKFFNNLELCK-GPSLGTNFTLAC-PYAIIAHYQELD 601
Cdd:PRK08574 278 PGLPSDP----YHGVAKRlfGKDLYGGVVS---FRVkggrDAVLKFLRSLKLIKpSPSLGGVESLATyPVKSAASPIPEE 350

                        330       340       350
                 ....*....|....*....|....*....|...
gi 6322590   602 EVAQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:PRK08574 351 DRKALGITEDLVRLSVGLEDVEDLIEDLDQALG 383
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 290-634 9.82e-17

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 82.28  E-value: 9.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    290 NPNTDV--------------YLFPSGMASIFTAHRLLLNFDAKRLSRSSSrqdkligYGPPFkktVMFGFpytdtlsILR 355
Cdd:pfam01053  46 NPTRDVleeriaaleggaaaLAFSSGMAAITAAILALLKAGDHIVATDDL-------YGGTY---RLFNK-------VLP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    356 KFN-HTHFLgqgDSTSMNALKNilHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY- 433
Cdd:pfam01053 109 RFGiEVTFV---DTSDPEDLEA--AIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLg 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    434 ADIVCSSLTKIFSGDSNVIAGSLVLNpRGKIYEFARKFMKTEDGyedCLWCEDALCLERNSRDFVERTIKVNTNTDILLK 513
Cdd:pfam01053 184 ADIVVHSATKYIGGHSDVVGGVIVVN-GEELGKELYFLQNATGA---VLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    514 rvLL---PQVgklfKKIYYPSLTSEDTKRNYDSVMStkdgGYGGLFSltfFNI----EEAKKFFNNLEL-CKGPSLG-TN 584
Cdd:pfam01053 260 --FLeshPKV----EKVYYPGLPSHPGHELAKRQMK----GFGGMLS---FELkgglEAAKKFLDNLKLfSLAVSLGgVE 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6322590    585 FTLACPyAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:pfam01053 327 SLISHP-ATMTHASIPPEErEAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 362-639 1.08e-15

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 79.17  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   362 FLGQGDStsmNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSS 440
Cdd:PRK08045 121 FVDQGDE---QALRAAL--AEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALgADLVLHS 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   441 LTKIFSGDSNVIAGSLVLNPRGKIYEFArkFMKTEDGYEDCLWceDALCLERNSRDFVERTIKVNTNTDILLKRVllpQV 520
Cdd:PRK08045 196 CTKYLNGHSDVVAGVVIAKDPDVVTELA--WWANNIGVTGGAF--DSYLLLRGLRTLVPRMELAQRNAQAIVKYL---QT 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   521 GKLFKKIYYPSLTSEDTKrnydSVMSTKDGGYGGLFSLTFFNIEEA-KKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQ 598
Cdd:PRK08045 269 QPLVKKLYHPSLPENQGH----EIAARQQKGFGAMLSFELDGDEQTlRRFLGGLSLFTlAESLGGVESLISHAATMTHAG 344

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 6322590   599 ELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE 639
Cdd:PRK08045 345 MAPEArAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG 386
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
296-634 2.19e-15

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 78.23  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   296 YLFPSGMASIfTAHRLLLNfdakrlsrsssRQDKLI----GYGPPFKktVMFGfpytdtlsILRKFNHTH-FLgqgDSTS 370
Cdd:PRK07671  69 FAFGSGMAAI-TAVMMLFS-----------SGDHVIltddVYGGTYR--VMTK--------VLNRFGIEHtFV---DTSN 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   371 MNALKNILHSGEQilAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVggfvnidVLPY--------ADIVCSSLT 442
Cdd:PRK07671 124 LEEVEEAIRPNTK--AIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTF-------MTPYwqspislgADIVLHSAT 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   443 KIFSGDSNVIAGSLVLNPRgkiyEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDillKRVLLPQVGK 522
Cdd:PRK07671 195 KYLGGHSDVVAGLVVVNSP----ELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSR---AIAEFLNNHP 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   523 LFKKIYYPSLtseDTKRNYDsVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQ-EL 600
Cdd:PRK07671 268 AVNKVYYPGL---PSHPNHE-LAKEQANGFGGMISFDVGSEETANKVLERLQYFTlAESLGAVESLISIPSQMTHASiPA 343

                        330       340       350
                 ....*....|....*....|....*....|....
gi 6322590   601 DEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:PRK07671 344 DRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
PRK08064 PRK08064
cystathionine beta-lyase MetC;
298-635 6.03e-14

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 74.04  E-value: 6.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   298 FPSGMASIFTAHRLLLNFDAKRLSRSSsrqdkligYGPPFKKTvmfgfpyTDTLSilrKFNHTH-FLgqgDSTSMNALKN 376
Cdd:PRK08064  75 FASGMAAISTAFLLLSKGDHVLISEDV--------YGGTYRMI-------TEVLS---RFGIEHtFV---DMTNLEEVAQ 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   377 ILHSGEQIlaVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETvggFVN------IDVlpYADIVCSSLTKIFSGDSN 450
Cdd:PRK08064 134 NIKPNTKL--FYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNT---FLTpllqkpLDL--GADVVLHSATKFLAGHSD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   451 VIAGSLVLNPRgkiyEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERtIKVNTNTDILLKRVL--LPQVgklfKKIY 528
Cdd:PRK08064 207 VLAGLAVVKDE----ELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVR-LEHSSETANKIALYLqeHPKV----QNVY 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   529 YPSLTSE---DTKRNYDSvmstkdgGYGGLFSLTFFNIEEAKKFFNNLELckgP----SLGTNFTLACPYAIIAHYQ-EL 600
Cdd:PRK08064 278 YPGLQTHlgfDIQQSQAT-------SAGAVLSFTLQSEEAVRQFVSHVKL---PvfavSLGAVESILSYPAKMSHAAmPK 347

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 6322590   601 DEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEK 635
Cdd:PRK08064 348 EERDERGITDGLLRLSVGLENVDDLIADFEQALSY 382
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
387-638 1.44e-13

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 73.00  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   387 VFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGSLVlnprgkiy 465
Cdd:PRK08861 142 ILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELgADFVIHSTTKYINGHSDVIGGVLI-------- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   466 efarkfMKTEDGYEDCLW---CE-------DALCLERNSRDFVERTIKVNTNTDILLKRVllpQVGKLFKKIYYPSLTSE 535
Cdd:PRK08861 214 ------TKTKEHAEELAWwgnCIgatgtpfDSYMTLRGIRTLGARMRVHEESAQQILAYL---QTQSLVGTIYHPSLPEH 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   536 DTKrnydSVMSTKDGGYGGLFSLTFF-NIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQELDE-VAQYGVETNL 612
Cdd:PRK08861 285 PGH----EIAKKQQSGFGSMLSFEFAgSFEQLKVFVKALALFSlAESLGGVESLICHPASMTHRAMGEEaLAEAGVSQQL 360

                        250       260
                 ....*....|....*....|....*.
gi 6322590   613 VRVSVGLENSDVLCNVFQRAIEKALG 638
Cdd:PRK08861 361 LRLSVGLEDAQDLIADLDQAFAKAAE 386
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 378-635 9.53e-12

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 67.17  E-value: 9.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   378 LHSGEQILA--------VFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGfvnidvlPY--------ADIVCSSL 441
Cdd:PRK06767 133 METEADIENkirpntklIFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNTFCS-------PYlqrplelgCDAVVHSA 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   442 TKIFSGDSNVIAGSLVlnprGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLL-PQV 520
Cdd:PRK06767 206 TKYIGGHGDVVAGVTI----CKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNhDAV 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   521 gklfKKIYYP--SLTSEDTKRNydsvmstkdggyGGLFSltfFNI----EEAKKFFNNLELCK-GPSLGTNFTLACPYAI 593
Cdd:PRK06767 282 ----EGVWYPegELASRQMKRG------------GGVIS---FSIkggkEETQAFINDLHFITiAVSLGDTETLIQHPAT 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 6322590   594 IAHYQELDEVAQ-YGVETNLVRVSVGLENSDVLCNVFQRAIEK 635
Cdd:PRK06767 343 MTHAAIPAELRQeMGIYDNLIRLSVGLESWEDIVSDLEQALKK 385
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 367-635 1.22e-11

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 66.77  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   367 DSTSMNALKNILHSGEQIlaVFIEAPSNPLLKMGDLQELKRLSDLYS--FYIVVDETVggfvnidVLPY--------ADI 436
Cdd:PRK06234 135 DTSNLEEVRNALKANTKV--VYLETPANPTLKVTDIKAISNIAHENNkeCLVFVDNTF-------CTPYiqrplqlgADV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   437 VCSSLTKIFSGDSNVIAGSLVlnprGKiYEFAR--KFMKTEDGYEDCLWCEDALCLERNSRDF---VERTIK-VNTNTDI 510
Cdd:PRK06234 206 VVHSATKYLNGHGDVIAGFVV----GK-EEFINqvKLFGIKDMTGSVIGPFEAFLIIRGMKTLqirMEKHCKnAMKVAKF 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   511 LLKRvllPQVgklfKKIYYPSLTSEDtkrnYDSVMSTKDGGYGGLFSLTFFN-IEEAKKFFNNLELCK-GPSLGTNFTLA 588
Cdd:PRK06234 281 LESH---PAV----EKVYYPGLESFE----YYELAKKQMSLPGAMISFELKGgVEEGKVVMNNVKLATlAVSLGDAETLI 349

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 6322590   589 CPYAIIAH--YQElDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEK 635
Cdd:PRK06234 350 QHPASMTHspYTA-EERKEAGISDGLVRLSVGLEDVDDIIADLKQALDL 397
PRK06460 PRK06460
hypothetical protein; Provisional
 387-635 1.24e-10

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 63.70  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   387 VFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGSLVLNprgkiY 465
Cdd:PRK06460 134 VFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPINQKPLELgADIVVHSASKFLAGHNDVIAGLAAGY-----G 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   466 EFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKrvLLPQVGKLfKKIYYPSLTSEDTKRNYDSVM 545
Cdd:PRK06460 209 KLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAE--FLEGHPKV-VKVYYPGLKSHVDYEIARRVL 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   546 StkdgGYGGLFSltfFNI----EEAKKFFNNLELC-KGPSL-GTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGL 619
Cdd:PRK06460 286 K----GFGGVLS---FEVnggqESALKVMKSLKLIiPAQTLgGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGI 358

                        250
                 ....*....|....*.
gi 6322590   620 ENSDVLCNVFQRAIEK 635
Cdd:PRK06460 359 EDVNDLIEDLDRALST 374
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 386-635 1.35e-10

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 63.51  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   386 AVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETvggFVNidvlPY--------ADIVCSSLTKIFSGDSNVIAGSLV 457
Cdd:PRK07811 149 LIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNT---FAS----PYlqqplalgADVVVHSTTKYIGGHSDVVGGALV 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   458 LNPRgkiyEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTN----TDILLKRvllPQVgklfKKIYYPSLT 533
Cdd:PRK07811 222 TNDE----ELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSENaeavAEFLAGH---PEV----STVLYPGLP 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   534 SEDTKRNYDSVMStkdgGYGGLFSLTFFNIEE-AKKFFNNLEL-CKGPSLGTNFTLacpyaiIAHYQELDEVAQYG---- 607
Cdd:PRK07811 291 SHPGHEVAARQMR----GFGGMVSVRLAGGEEaARDFCARTKVfTLAESLGGVESL------IEHPSAMTHASTAGsqle 360

                        250       260
                 ....*....|....*....|....*...
gi 6322590   608 VETNLVRVSVGLENSDVLCNVFQRAIEK 635
Cdd:PRK07811 361 VPDDLVRLSVGIEDVADLLADLEQALGQ 388
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
387-634 1.94e-10

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 63.22  E-value: 1.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   387 VFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGsLVLNPRG--- 462
Cdd:PRK08249 153 LYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALgADLVIHSATKFLSGHADALGG-VVCGSKElme 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   463 KIYEFARKFMKTEDGYEdclwcedALCLERNSRDFVERTIKVNTNTdILLKRVLLPQvgKLFKKIYYPSLTSEDTKRNYD 542
Cdd:PRK08249 232 QVYHYREINGATMDPMS-------AYLILRGMKTLKLRVRQQQESA-MALAKYLQTH--PKVEAVYYPGLETHPNHEIAK 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   543 SVMStkdgGYGGLFSLTFF-NIEEAKKFFNNLELC-KGPSLGTNFTLACPYAIIAHYQ-ELDEVAQYGVETNLVRVSVGL 619
Cdd:PRK08249 302 AQMR----GFGGILSFVLKgGMDTVKRLLPKLRYAhRAANLGAVETIYGPARTTSHVEnTLEERAALGIPEGLVRISVGI 377

                        250
                 ....*....|....*
gi 6322590   620 ENSDVLCNVFQRAIE 634
Cdd:PRK08249 378 EDTEDLIADLEQAFA 392
PRK07049 PRK07049
cystathionine gamma-synthase family protein;
297-636 2.67e-10

cystathionine gamma-synthase family protein;


Pssm-ID: 180809 [Multi-domain]  Cd Length: 427  Bit Score: 62.77  E-value: 2.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   297 LFPSGMASIFTahrLLLNFdakrlsrssSRQDKLIGYGPPFkktvmfgFPYTDTL--SILRKFNhTHFLGQGDSTSMNAL 374
Cdd:PRK07049 103 LFSSGMSAIAT---TLLAF---------VRPGDVILHSQPL-------YGGTETLlaKTFRNFG-VGAVGFADGLSEAAI 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   375 KNILHSGEQ---ILAVFIEAPSNPLLKMGDLQELKRLSDL------YSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKI 444
Cdd:PRK07049 163 GAAAEAAAAkgrVSLILIETPANPTNSLVDVAAVRRVADAiearqgHRPIIACDNTLLGPVFQKPLEHgADLSVYSLTKY 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   445 FSGDSNVIAGSlVLNPRGKIYEFA--RKFMKTEDGYEDClWCedalcLERNSRDFVERTIKVNTNTDILLKrvLLPQVGK 522
Cdd:PRK07049 243 VGGHSDLVAGA-VLGRKALIRQVRalRSAIGTQLDPHSC-WM-----LGRSLETLVLRMERANRNARAVAE--FLRDHPK 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   523 LFKKIYYPSLTSEDTkrnYDSVMSTKDGGYGGLFSltfFNI----EEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHY 597
Cdd:PRK07049 314 VEKLHYLPFLDPDSA---YGAVYKRQCTGAGSTFS---FDIkggqAAAFRFLNALQIFKlAVSLGGTESLASHPASMTHS 387

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 6322590   598 QELDEVAQ-YGVETNLVRVSVGLENSDVLCNVFQRAIEKA 636
Cdd:PRK07049 388 GVPADVRErIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
PRK06434 PRK06434
cystathionine gamma-lyase; Validated
 386-635 3.12e-10

cystathionine gamma-lyase; Validated


Pssm-ID: 102374 [Multi-domain]  Cd Length: 384  Bit Score: 62.61  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   386 AVFIEAPSNPLLKMGDLQELKRLSdlYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGSLVLNPRG-- 462
Cdd:PRK06434 151 LIYAESITNPTLKVPDIKNVSSFC--HENDVIVDATFASPYNQNPLDLgADVVIHSATKYISGHSDVVMGVAGTNNKSif 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   463 -KIYEFARKFMKTEDGYEDCLWCED----ALCLERNSRDFVERTIKVNTNTDILlkrvllpqvgklfkKIYYPSLtsEDT 537
Cdd:PRK06434 229 nNLVERRKTLGSNPDPIQAYLALRGlktlGLRMEKHNKNGMELARFLRDSKKIS--------------NVYYPDT--EIG 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   538 KRnydsVMStkdgGYGGLFSLTFFNIEEAKKFFNNLEL-CKGPSLGTNFTLACPYAIIAHYQ-ELDEVAQYGVETNLVRV 615
Cdd:PRK06434 293 KK----VLR----GFGGMLSFELRSMEDVHKFIRNLEIpMVAASLGGVESLITLPVETSHSSlSPEERERLGISDNLVRF 364

                        250       260
                 ....*....|....*....|
gi 6322590   616 SVGLENSDVLCNVFQRAIEK 635
Cdd:PRK06434 365 SIGIEDIDDLIKDIENALSK 384
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
361-636 1.95e-09

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 60.00  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   361 HF-LGQGDSTSMNALKNILHSGEQIlaVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVC 438
Cdd:PRK08776 124 HFaLITADLTDPRSLADALAQSPKL--VLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFgADLVL 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   439 SSLTKIFSGDSNVIAGSLVlnprgkiyefarkfMKTEDGYEDCLWCEDALCLE----------RNSRDFVERTIKVNTNT 508
Cdd:PRK08776 202 HSTTKYINGHSDVVGGAVV--------------ARDAELHQQLVWWANALGLTgspfdafltlRGLRTLDARLRVHQENA 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   509 DILLkrVLLPQVGKLfKKIYYPSLTSEDTKrnydSVMSTKDGGYGGLFSLTFFNIEEA-KKFFNNLE-LCKGPSLGTNFT 586
Cdd:PRK08776 268 DAIA--ALLDGHAAV-NQVYYPGLASHPGH----ALAARQQKGFGAMLSFELEGGEAAvRAFVDGLRyFTLAESLGGVES 340

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6322590   587 LACPYAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIEKA 636
Cdd:PRK08776 341 LIAHPASMTHAAMTAEArAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
PLN02242 PLN02242
methionine gamma-lyase
 360-618 1.99e-09

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 60.16  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   360 THFLGQG--------DSTSMNALKNILHSGEQILaVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETvggFVNIDVL 431
Cdd:PLN02242 133 AHFLPRKcnitttfvDITDLEAVKKAVVPGKTKV-LYFESISNPTLTVADIPELARIAHEKGVTVVVDNT---FAPMVLS 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   432 PY---ADIVCSSLTKIFSGDSNVIAGSlVLNPRgkiyEFARKFMKTEDGyedclwcedALCL--------------ERNS 494
Cdd:PLN02242 209 PArlgADVVVHSISKFISGGADIIAGA-VCGPA----ELVNSMMDLHHG---------ALMLlgptmnpkvafelsERLP 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   495 ------RDFVERTIKVNTntdillkrvllpQVGKLFKKIYYPSLTSEDTKRNYDSvMSTKDGGYGGLFSLTFFNIEEAKK 568
Cdd:PLN02242 275 hlslrmKEHCRRAMEYAK------------RMKELGLKVIYPGLEDHPQHALLKS-MANKGYGFGGLLCLDMDTEERANR 341

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6322590   569 FFNNLELCKG-----PSLGTNFTL-ACPYAIIAHYQELDEVAQYGVETNLVRVSVG 618
Cdd:PLN02242 342 LMRYLQNSTQfgfmaVSLGYYETLmSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
367-634 5.84e-09

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 58.55  E-value: 5.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   367 DSTSMNALKNILHSGEQIlaVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGG---FVNIDVlpYADIVCSSLTK 443
Cdd:PRK05939 117 DATDVQNVAAAIRPNTRM--VFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSpwlFRPKDV--GASLVINSLSK 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   444 IFSGDSNVIAGSLV------LNPRGKIYEFARKFMKTEDGYED-----------CLWCEDALCLERNSRDFVERTIKVNT 506
Cdd:PRK05939 193 YIAGHGNALGGAVTdtglfdWSAYPNIFPAYRKGDPQQWGLTQirkkglrdmgaTLSSEAAHRIAIGAETLALRVDRSCS 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   507 NTdILLKRVLL--PQVGKlfkkIYYPSLTS----EDTKRNYdsvmstkdGGYGGLFSLTFFNIEEAKKFFNNLEL-CKGP 579
Cdd:PRK05939 273 NA-LALAQFLEahPKVAR----VYYPGLAShpqhARATELF--------RHYGGLLSFELADGIDCFDFLNRLKLvIKAT 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6322590   580 SLGTNFTLACPYAIIAHYQELDEV-AQYGVETNLVRVSVGLENSDVLCNVFQRAIE 634
Cdd:PRK05939 340 HLGDTRTLVIPVAPTIYYEMGAERrASMGIADSLIRVSVGIEDEADLIADFEQALD 395
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 367-636 1.98e-08

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 56.76  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    367 DSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIF 445
Cdd:TIGR01329 117 DTTDLDKVKAAL--GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELgADIVYHSATKFL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    446 SGDSNVIAGSLVLNPRgkiyEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILlkrVLLPQVGKLFK 525
Cdd:TIGR01329 195 AGHSDVMAGVLAVKGE----EIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAI---AMFLSTHPRVK 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590    526 KIYYPSLTSEDtkrNYDSVMSTKDGGyGGLFSLTFFNIEEAKKFfnnLELCKGPSLGTNF-------TLACPYAIIAHYQ 598
Cdd:TIGR01329 268 KVRYAGLPSHP---GFHLHFSQAKGA-GSVLSFETGSVALSKRL---VEATKLFSITVSFgsvnsliSMPCFMSHASIPA 340

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 6322590    599 ELDEVAQYGVEtnLVRVSVGLENSDVLCNVFQRAIEKA 636
Cdd:TIGR01329 341 EVREERGLPED--LVRLSVGIEDVDDLISDLDIAFVTA 376
PLN02509 PLN02509
cystathionine beta-lyase
 381-625 2.11e-08

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 56.96  E-value: 2.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   381 GEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGslVLN 459
Cdd:PLN02509 215 GPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELgADIVMHSATKFIAGHSDVMAG--VLA 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   460 PRGKIYEFARKFMKTEDGYE----DClWcedaLCLeRNSRDFVERTIKVNTNT-DILLKRVLLPQVgklfKKIYYPSLTS 534
Cdd:PLN02509 293 VKGEKLAKEVYFLQNSEGSGlapfDC-W----LCL-RGIKTMALRIEKQQENArKIAMYLSSHPRV----KKVYYAGLPD 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   535 EDTKrnydSVMSTKDGGYGGLFSLTFFNIEEAKKFfnnLELCKGPSLGTNF----TLACPYAIIAHYQELDEVAQ-YGVE 609
Cdd:PLN02509 363 HPGH----HLHFSQAKGAGSVFSFITGSVALSKHL---VETTKYFSIAVSFgsvkSLISMPCFMSHASIPAEVREaRGLT 435

                        250
                 ....*....|....*.
gi 6322590   610 TNLVRVSVGLENSDVL 625
Cdd:PLN02509 436 EDLVRISAGIEDVDDL 451
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 382-634 2.41e-07

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 53.29  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   382 EQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIVCSSLTKIFSGDSNVIAGSLVLNP 460
Cdd:PRK07269 135 EDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELgADIVLHSATKYLSGHNDVLAGVVVTND 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   461 RgKIYEfarKFMKTEDGYEDCLWCEDALCLERNSRDF---VERTIKVNTNTDILLKRvlLPQVgklfKKIYYPsltsedt 537
Cdd:PRK07269 215 L-ELYE---KLFYNLNTTGAVLSPFDSYLLMRGLKTLslrMERSTANAQEVVAFLKK--SPAV----KEVLYT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   538 krnydsvmstkdgGYGGLFSLTFFNIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHYQELDEV-AQYGVETNLVRV 615
Cdd:PRK07269 278 -------------GKGGMISFKVADETRIPHILNSLKVFTfAESLGGVESLITYPTTQTHADIPAEVrHSYGLTDDLLRL 344

                        250
                 ....*....|....*....
gi 6322590   616 SVGLENSDVLCNVFQRAIE 634
Cdd:PRK07269 345 SIGIEDARDLIADLKQALE 363
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
296-457 6.29e-07

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 52.01  E-value: 6.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   296 YLFPSGMASIFTAHRLllnFDAKrlsrsssrqDKLIG----YGPPFKktvMFGFPYtdtlsilrKFNHTHFLgQGDSTSM 371
Cdd:PRK08247  71 FACSSGMAAIQLVMSL---FRSG---------DELIVssdlYGGTYR---LFEEHW--------KKWNVRFV-YVNTASL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   372 NALKNILHsgEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETvggFVNidvlPY--------ADIVCSSLTK 443
Cdd:PRK08247 127 KAIEQAIT--PNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVDNT---FYT----PVlqrpleegADIVIHSATK 197

                        170
                 ....*....|....
gi 6322590   444 IFSGDSNVIAGSLV 457
Cdd:PRK08247 198 YLGGHNDVLAGLVV 211
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 367-630 7.50e-07

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 51.73  E-value: 7.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   367 DSTSMNALKNILhsGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVggfvnidVLPY--------ADIVC 438
Cdd:PRK07503 136 DLTDPAALKAAI--SDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTY-------CTPYlqrplelgADLVV 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   439 SSLTKIFSGDSNVIAGsLVLNPRGKIYEFARKFMKTEDGyeDCLWCEDALCLERNSRDFVERTIKVNTNTDI---LLKRv 515
Cdd:PRK07503 207 HSATKYLGGHGDITAG-LVVGGKALADRIRLEGLKDMTG--AVMSPFDAFLLMRGLKTLALRMDRHCASAQAvaeWLAR- 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   516 lLPQVgklfKKIYYPSLTSEDTKRNYDSVMSTkdggYGGL--FSLTfFNIEEAKKFFNNLEL-CKGPSLGTNFTLACPYA 592
Cdd:PRK07503 283 -HPAV----ELVHYPGLPSFAQHALAQRQMAL----PGGMiaFELK-GGIAAGRRFMNALQLfARAVSLGDAESLAQHPA 352

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 6322590   593 IIAH--YQElDEVAQYGVETNLVRVSVGLEN-SDVLCNVFQ 630
Cdd:PRK07503 353 SMTHstYTP-EERAEHGISEGLVRLSVGLEDvADILADLAQ 392
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
359-638 3.42e-05

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 46.82  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   359 HTHFLGQGDSTSMNALKNilhsgEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPY-ADIV 437
Cdd:PRK06084 124 ETRFAAHDDIAALEALID-----ERTKAVFCESIGNPAGNIIDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHgADIV 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   438 CSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKF--MKTED-GYEDCLWCED---------------------------- 486
Cdd:PRK06084 199 VHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFalLNTPDpSYHGVTYTEAfgpaafigrcrvvplrnmgaalspfnaf 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   487 ---------ALCLERNSrdfvERTIKVntnTDILLKRvllPQVGKLfKKIYYPSLTSEDTKRNYdsvMSTKDGgygglfS 557
Cdd:PRK06084 279 lilqgletlALRMERHT----ENALKV---ARYLQQH---PQVAWV-KYAGLPDHPEHELARRY---MGGKPA------S 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   558 LTFFNI----EEAKKFFNNLEL-CKGPSLGTNFTLACPYAIIAHYQELD-EVAQYGVETNLVRVSVGLENSDVLCNVFQR 631
Cdd:PRK06084 339 ILSFGIkggqAAGARFIDALKLvVRLVNIGDAKSLACHPASTTHRQLNDeELEKAGVSRDMVRLSIGIEHIDDIIADLAQ 418


                 ....*..
gi 6322590   632 AIEKALG 638
Cdd:PRK06084 419 ALDASKG 425
PRK05968 PRK05968
hypothetical protein; Provisional
 551-637 4.28e-05

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 46.23  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   551 GYGGLFSLTFFNIEEAKKFFNNLELCK-GPSLGTNFTLACP-YAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNV 628
Cdd:PRK05968 300 GTSGLFSFIFREGIDVRAFADALKLFRlGVSWGGHESLVVPaEVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWAD 379


                 ....*....
gi 6322590   629 FQRAIEKAL 637
Cdd:PRK05968 380 LEQALAAAS 388
PRK07050 PRK07050
cystathionine beta-lyase; Provisional
 551-638 3.69e-03

cystathionine beta-lyase; Provisional


Pssm-ID: 180810 [Multi-domain]  Cd Length: 394  Bit Score: 40.09  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322590   551 GYGGLFSLTF---FNIEEAKKFFNNLELCK-GPSLGTNFTLACPYAIIAHyqeldEVAQYGVETNLVRVSVGLENSDVLC 626
Cdd:PRK07050 308 GAGGLFSVVFderYSPAQVDAFVEALELFAiGWSWGGACSLAMPYDVASM-----RTAKWPHRGTLVRLYIGLEDEADLI 382

                         90
                 ....*....|..
gi 6322590   627 NVFQRAIEKALG 638
Cdd:PRK07050 383 ADLEQALEAALA 394
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH