|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1282 |
2.90e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 448.18 E-value: 2.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 970 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNhggGNTP 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGE---SDKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1050 GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1129
Cdd:cd02897 78 GSTWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1130 THSAVRNALFCLETAWASIsqsqeSHVYTKALLAYAFALAGNKaKRSELLESLNKDAVKEEDSLHWQRPgdvQKVKALSF 1209
Cdd:cd02897 158 ERPVVEKALSCLEAALDSI-----SDPYTLALAAYALTLAGSE-KRPEALKKLDELAISEDGTKHWSRP---PPSEEGPS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347469 1210 YQPRAPSAEVEMTAYVLLAYLTsessrptrdLSSSDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1282
Cdd:cd02897 229 YYWQAPSAEVEMTAYALLALLS---------AGGEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
750-840 |
6.78e-39 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 140.03 E-value: 6.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 750 TWIWDLVPLDVSGDGELAVKVPDTITEWKASAFCLSGTTGLGLSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNY 829
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 110347469 830 MSHCIQIRVDL 840
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1393-1483 |
8.80e-36 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 131.15 E-value: 8.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1393 PSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNT-NHVLIYIEKLTNQTLGFSFAVEQDIPVKNLKPAPIKVYDY 1471
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDdGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 110347469 1472 YETDEFTVEEYS 1483
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1401 |
1.65e-34 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 144.84 E-value: 1.65e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 127 VFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETfPV-VYIETPkRNRIFQWQNIHL-AGGLHQLSFPLSVEPALGIYKVV 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 205 VQKDSGKKI-EHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGL-----VTLRVCRK-------YS 271
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvegeVTLRPARTafpgypgYR 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 272 RYRSTCHNQNSMSicEEFSQQADDKGCFRQVVKTKvfQLRQKGHDMKIEVEAKIKEEGtGIELTGIGSCEIANA-----L 346
Cdd:COG2373 529 FGDPDEEFEPEEL--DLGEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG-GRPVTRSATVPVHPAdfyvgI 603
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 347 SKLKFTKVNTNYrpglPFSGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEHG------------LANISIDTS--- 411
Cdd:COG2373 604 RLPLFDGDPEGA----PATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGgwryesqekeepVAEGTLTTGadg 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 412 ----NFTAP---FLRVVVTYKQNHVC--YDNWWLDEFHTQADHSATLVFSPSQ-SYiqlelvfgtlACGQTQEIRIhyll 481
Cdd:COG2373 680 paslSLTPVewgRYRLEVKDPDGGLAtsVRFYAGGNASWGAERPDRLELSLDKeSY----------KPGETAKLLI---- 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 482 nedimknekdlTFYYliKARGSIFNLGSHVLSLEQGNMKG---VFSLPiqVEPGMAPEAQLLIYAILPNEELVADA---- 554
Cdd:COG2373 746 -----------QSPF--AGRALVTVERDGVLETQWVDVKGggtTVEIP--VTEDWAPNAYVSATLVRPGDSTANDMpara 810
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 555 ---QNFEIEKCfANKVNLSF-PSAQSLPASDTHLKVKAAPLSLCA----LTAVDQSVLLLKPEAKLSPQsiynllpgktv 626
Cdd:COG2373 811 ygvAPLPVDPP-ARRLKVELtAPEKLRPGETLTVTVKVKGAAGKAaevtLAAVDEGILNLTGYKTPDPL----------- 878
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 627 qGAFFGvpvykdhencisgedithngivytpKHSLGDnDAHSIFQSVginiftnskihkprfcqefqhYPAMGGvapqAL 706
Cdd:COG2373 879 -DFFYG-------------------------KRALGV-ETRDLYGRL---------------------IGAFGG----AA 906
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 707 AVAASGpgssframGVPMMGLDysdeinqvvEVRETVRKYFPETWIWD-LVPLDVSGDGELAVKVPDTITEWKASAFCLS 785
Cdd:COG2373 907 GALRSG--------GDGALGRG---------GNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS 969
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 786 GTtGLGlSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVDLEISPDFlaVPVGGHENSHCICGNER 865
Cdd:COG2373 970 DD-RFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEATQTVTLAAGGR 1045
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 866 KTVSWAVTPKSLGEVNFTATAEAlqspelcGNKltevpalvhKDTVVKSVIVEPEGIEKEQTYNTLLCPQDTELQDnwsL 945
Cdd:COG2373 1046 ATVRFPLKAPDAGDAKVTVTATG-------GGE---------SDAREVELPVRPANPLVTRATSGVLAPGESWTLP---L 1106
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 946 ELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNyLNETQQLTEAIKSKAINYLISGYQ 1025
Cdd:COG2373 1107 DLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1026 RQLNYQHSDGSYSTFgnhgGGNTPGNTWLTAFVLKAFAQAQSH-IFIEKTHITNAFNWLSMKQKENGcfqqsgyllnnAM 1104
Cdd:COG2373 1186 RLLSMQNSDGGFGLW----PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW-----------EI 1250
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1105 KGGVDDEVTLSAYITIALLEMPLPVTHSAvrNALFCLETAWAS-ISQSQESHVYtkallayafALAGNKAKRSELLESLN 1183
Cdd:COG2373 1251 EYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSpLAKAQLAAAL---------ALLGDKARAEELLAAAL 1319
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1184 KDAVKEEDSLHWqrpgdvqkvkaLSFYqprapSAEVEMTAYVLLAYLTSESSRPTRDlsssdlstasKIVKWISKQQNSh 1263
Cdd:COG2373 1320 ARLRETGARDYW-----------YGDY-----GSPLRDQALALALLAELGPDAPLAP----------KLARWLAKALKS- 1372
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1264 GGFSSTQDTVVALQALSKYGAAtfTRSQKEVLVTIESSGtfsKTFHVNSGNRLLLQEVRLPDLPGNYVT-KGSGSGCVYL 1342
Cdd:COG2373 1373 GRWLSTQETAWALLALAAYARA--AGASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELLAGPLTiTNTGDGPLYY 1447
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110347469 1343 QTSLKY--NILPVADGKAPFALQVNTLPLNFD-------KAGDhrTFQIRINVSyTGERPSSNMVIVD 1401
Cdd:COG2373 1448 TLTLSGypAEGPPPAASNGLEIERRYYDLDGKpidpaslKQGD--LVVVRLTVT-APSGRVENVAVVD 1512
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1282 |
2.90e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 448.18 E-value: 2.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 970 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNhggGNTP 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGE---SDKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1050 GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1129
Cdd:cd02897 78 GSTWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1130 THSAVRNALFCLETAWASIsqsqeSHVYTKALLAYAFALAGNKaKRSELLESLNKDAVKEEDSLHWQRPgdvQKVKALSF 1209
Cdd:cd02897 158 ERPVVEKALSCLEAALDSI-----SDPYTLALAAYALTLAGSE-KRPEALKKLDELAISEDGTKHWSRP---PPSEEGPS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347469 1210 YQPRAPSAEVEMTAYVLLAYLTsessrptrdLSSSDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1282
Cdd:cd02897 229 YYWQAPSAEVEMTAYALLALLS---------AGGEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
961-1282 |
2.16e-143 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 440.97 E-value: 2.16e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 961 SVLGDILGSAMQ----NLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGS 1036
Cdd:pfam07678 2 SVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1037 YSTFgnhggGNTPGNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSA 1116
Cdd:pfam07678 82 YSAF-----GHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1117 YITIALLEM-----PLPVTHSAVRNALFCLETAwasiSQSQESHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEED 1191
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1192 SLHWQRPGDVQKVKALSfYQPRAPSAEVEMTAYVLLAYLTSEssrptrdlsssDLSTASKIVKWISKQQNSHGGFSSTQD 1271
Cdd:pfam07678 233 SRYWERDEKSDPQGVPE-YPPQAPSLEVETTAYALLAYLLLG-----------DLTYADPIVKWLTSQRNSHGGFSSTQD 300
|
330
....*....|.
gi 110347469 1272 TVVALQALSKY 1282
Cdd:pfam07678 301 TVVALQALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
750-840 |
6.78e-39 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 140.03 E-value: 6.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 750 TWIWDLVPLDVSGDGELAVKVPDTITEWKASAFCLSGTTGLGLSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNY 829
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 110347469 830 MSHCIQIRVDL 840
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1393-1483 |
8.80e-36 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 131.15 E-value: 8.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1393 PSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNT-NHVLIYIEKLTNQTLGFSFAVEQDIPVKNLKPAPIKVYDY 1471
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDdGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 110347469 1472 YETDEFTVEEYS 1483
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1401 |
1.65e-34 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 144.84 E-value: 1.65e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 127 VFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETfPV-VYIETPkRNRIFQWQNIHL-AGGLHQLSFPLSVEPALGIYKVV 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 205 VQKDSGKKI-EHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGL-----VTLRVCRK-------YS 271
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvegeVTLRPARTafpgypgYR 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 272 RYRSTCHNQNSMSicEEFSQQADDKGCFRQVVKTKvfQLRQKGHDMKIEVEAKIKEEGtGIELTGIGSCEIANA-----L 346
Cdd:COG2373 529 FGDPDEEFEPEEL--DLGEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG-GRPVTRSATVPVHPAdfyvgI 603
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 347 SKLKFTKVNTNYrpglPFSGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEHG------------LANISIDTS--- 411
Cdd:COG2373 604 RLPLFDGDPEGA----PATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGgwryesqekeepVAEGTLTTGadg 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 412 ----NFTAP---FLRVVVTYKQNHVC--YDNWWLDEFHTQADHSATLVFSPSQ-SYiqlelvfgtlACGQTQEIRIhyll 481
Cdd:COG2373 680 paslSLTPVewgRYRLEVKDPDGGLAtsVRFYAGGNASWGAERPDRLELSLDKeSY----------KPGETAKLLI---- 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 482 nedimknekdlTFYYliKARGSIFNLGSHVLSLEQGNMKG---VFSLPiqVEPGMAPEAQLLIYAILPNEELVADA---- 554
Cdd:COG2373 746 -----------QSPF--AGRALVTVERDGVLETQWVDVKGggtTVEIP--VTEDWAPNAYVSATLVRPGDSTANDMpara 810
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 555 ---QNFEIEKCfANKVNLSF-PSAQSLPASDTHLKVKAAPLSLCA----LTAVDQSVLLLKPEAKLSPQsiynllpgktv 626
Cdd:COG2373 811 ygvAPLPVDPP-ARRLKVELtAPEKLRPGETLTVTVKVKGAAGKAaevtLAAVDEGILNLTGYKTPDPL----------- 878
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 627 qGAFFGvpvykdhencisgedithngivytpKHSLGDnDAHSIFQSVginiftnskihkprfcqefqhYPAMGGvapqAL 706
Cdd:COG2373 879 -DFFYG-------------------------KRALGV-ETRDLYGRL---------------------IGAFGG----AA 906
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 707 AVAASGpgssframGVPMMGLDysdeinqvvEVRETVRKYFPETWIWD-LVPLDVSGDGELAVKVPDTITEWKASAFCLS 785
Cdd:COG2373 907 GALRSG--------GDGALGRG---------GNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS 969
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 786 GTtGLGlSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVDLEISPDFlaVPVGGHENSHCICGNER 865
Cdd:COG2373 970 DD-RFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEATQTVTLAAGGR 1045
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 866 KTVSWAVTPKSLGEVNFTATAEAlqspelcGNKltevpalvhKDTVVKSVIVEPEGIEKEQTYNTLLCPQDTELQDnwsL 945
Cdd:COG2373 1046 ATVRFPLKAPDAGDAKVTVTATG-------GGE---------SDAREVELPVRPANPLVTRATSGVLAPGESWTLP---L 1106
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 946 ELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNyLNETQQLTEAIKSKAINYLISGYQ 1025
Cdd:COG2373 1107 DLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1026 RQLNYQHSDGSYSTFgnhgGGNTPGNTWLTAFVLKAFAQAQSH-IFIEKTHITNAFNWLSMKQKENGcfqqsgyllnnAM 1104
Cdd:COG2373 1186 RLLSMQNSDGGFGLW----PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW-----------EI 1250
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1105 KGGVDDEVTLSAYITIALLEMPLPVTHSAvrNALFCLETAWAS-ISQSQESHVYtkallayafALAGNKAKRSELLESLN 1183
Cdd:COG2373 1251 EYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSpLAKAQLAAAL---------ALLGDKARAEELLAAAL 1319
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1184 KDAVKEEDSLHWqrpgdvqkvkaLSFYqprapSAEVEMTAYVLLAYLTSESSRPTRDlsssdlstasKIVKWISKQQNSh 1263
Cdd:COG2373 1320 ARLRETGARDYW-----------YGDY-----GSPLRDQALALALLAELGPDAPLAP----------KLARWLAKALKS- 1372
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1264 GGFSSTQDTVVALQALSKYGAAtfTRSQKEVLVTIESSGtfsKTFHVNSGNRLLLQEVRLPDLPGNYVT-KGSGSGCVYL 1342
Cdd:COG2373 1373 GRWLSTQETAWALLALAAYARA--AGASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELLAGPLTiTNTGDGPLYY 1447
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110347469 1343 QTSLKY--NILPVADGKAPFALQVNTLPLNFD-------KAGDhrTFQIRINVSyTGERPSSNMVIVD 1401
Cdd:COG2373 1448 TLTLSGypAEGPPPAASNGLEIERRYYDLDGKpidpaslKQGD--LVVVRLTVT-APSGRVENVAVVD 1512
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
458-606 |
3.65e-30 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 116.68 E-value: 3.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 458 IQLELVFGTLACGQTQEIRIHYLLNEDIMKNEkdltFYYLIKARGSIfnlgshvlsLEQGNMKGVFSLPIQVEPGMAPEA 537
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDG----FTYLVLSKGQI---------VVVGRGGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110347469 538 QLLIYAI---LPNEELVADAQNFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALTAVDQSVLLL 606
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1282 |
2.90e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 448.18 E-value: 2.90e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 970 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNhggGNTP 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGE---SDKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1050 GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1129
Cdd:cd02897 78 GSTWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1130 THSAVRNALFCLETAWASIsqsqeSHVYTKALLAYAFALAGNKaKRSELLESLNKDAVKEEDSLHWQRPgdvQKVKALSF 1209
Cdd:cd02897 158 ERPVVEKALSCLEAALDSI-----SDPYTLALAAYALTLAGSE-KRPEALKKLDELAISEDGTKHWSRP---PPSEEGPS 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347469 1210 YQPRAPSAEVEMTAYVLLAYLTsessrptrdLSSSDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1282
Cdd:cd02897 229 YYWQAPSAEVEMTAYALLALLS---------AGGEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
961-1282 |
2.16e-143 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 440.97 E-value: 2.16e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 961 SVLGDILGSAMQ----NLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGS 1036
Cdd:pfam07678 2 SVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1037 YSTFgnhggGNTPGNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSA 1116
Cdd:pfam07678 82 YSAF-----GHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1117 YITIALLEM-----PLPVTHSAVRNALFCLETAwasiSQSQESHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEED 1191
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1192 SLHWQRPGDVQKVKALSfYQPRAPSAEVEMTAYVLLAYLTSEssrptrdlsssDLSTASKIVKWISKQQNSHGGFSSTQD 1271
Cdd:pfam07678 233 SRYWERDEKSDPQGVPE-YPPQAPSLEVETTAYALLAYLLLG-----------DLTYADPIVKWLTSQRNSHGGFSSTQD 300
|
330
....*....|.
gi 110347469 1272 TVVALQALSKY 1282
Cdd:pfam07678 301 TVVALQALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
970-1282 |
2.52e-103 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 330.89 E-value: 2.52e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 970 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNHGggntP 1049
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSD----S 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1050 GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1129
Cdd:cd02891 77 GSTWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1130 tHSAVRNALFCLETAWASIsqsqeSHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEEDSLHWQrpgdvqkvkaLSF 1209
Cdd:cd02891 157 -DASIEKALAYLETQLDGL-----LDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWS----------LSW 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110347469 1210 YQPRAPSAEVEMTAYVLLAYLTSEssrptrdlsssDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1282
Cdd:cd02891 221 PGDYGSSLRVEATAYALLALLKLG-----------DLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
973-1282 |
2.70e-74 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 249.50 E-value: 2.70e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 973 NLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQ---LTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNhgggnTP 1049
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKN-----RP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1050 GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGV---DDEVTLSAYITIALLE-- 1124
Cdd:cd02896 79 SSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEar 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1125 --MPLPVT--HSAVRNALFCLETawasiSQSQESHVYTKALLAYAFALAgNKAKRSELLESLNKDAVKEEDSLHWQRPGd 1200
Cdd:cd02896 159 siCPPEVQnlDQSIRKAISYLEN-----QLPNLQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYWWTID- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1201 vqkvkALSFYQPRAPSAEVEMTAYVLLAYLTSEssrptrdlsssDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALS 1280
Cdd:cd02896 232 -----SPYWPVPGPSAITVETTAYALLALLKLG-----------DIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALA 295
|
..
gi 110347469 1281 KY 1282
Cdd:cd02896 296 EY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
970-1282 |
5.05e-60 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 208.56 E-value: 5.05e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 970 AMQNLQNLLQMPYG--------CGEQNMVLFVPNIYVLNYLNETQqlteaIKSKAINYLISGYQRQLNYQHSDGSYSTFG 1041
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1042 NHGggntPGNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMkgGVDDEVTLSAYITIA 1121
Cdd:cd00688 76 GND----YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1122 LLEMPLPVTHSAVRNALFCLETAWA---SISQSQESHVYTKALLAYAFALAG--NKAKRSELLESLNKDAVKEEDSLHWQ 1196
Cdd:cd00688 150 LALLGKLDPDPLIEKALDYLLSCQNydgGFGPGGESHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1197 RPgdvqkvkalsfYQPRAPSAEVEMTAYVLLAYltsessrptrdLSSSDLSTASKIVKWISKQQNSHGGFSS-------T 1269
Cdd:cd00688 230 DR-----------TNKLSDSCYTEWAAYALLAL-----------GKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydT 287
|
330
....*....|...
gi 110347469 1270 QDTVVALQALSKY 1282
Cdd:cd00688 288 QHTVFALLALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
750-840 |
6.78e-39 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 140.03 E-value: 6.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 750 TWIWDLVPLDVSGDGELAVKVPDTITEWKASAFCLSGTTGLGLSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNY 829
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 110347469 830 MSHCIQIRVDL 840
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1393-1483 |
8.80e-36 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 131.15 E-value: 8.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1393 PSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNT-NHVLIYIEKLTNQTLGFSFAVEQDIPVKNLKPAPIKVYDY 1471
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDdGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 110347469 1472 YETDEFTVEEYS 1483
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1401 |
1.65e-34 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 144.84 E-value: 1.65e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 127 VFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETfPV-VYIETPkRNRIFQWQNIHL-AGGLHQLSFPLSVEPALGIYKVV 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDP-DGKEVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 205 VQKDSGKKI-EHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGL-----VTLRVCRK-------YS 271
Cdd:COG2373 449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvegeVTLRPARTafpgypgYR 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 272 RYRSTCHNQNSMSicEEFSQQADDKGCFRQVVKTKvfQLRQKGHDMKIEVEAKIKEEGtGIELTGIGSCEIANA-----L 346
Cdd:COG2373 529 FGDPDEEFEPEEL--DLGEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG-GRPVTRSATVPVHPAdfyvgI 603
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 347 SKLKFTKVNTNYrpglPFSGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEHG------------LANISIDTS--- 411
Cdd:COG2373 604 RLPLFDGDPEGA----PATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGgwryesqekeepVAEGTLTTGadg 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 412 ----NFTAP---FLRVVVTYKQNHVC--YDNWWLDEFHTQADHSATLVFSPSQ-SYiqlelvfgtlACGQTQEIRIhyll 481
Cdd:COG2373 680 paslSLTPVewgRYRLEVKDPDGGLAtsVRFYAGGNASWGAERPDRLELSLDKeSY----------KPGETAKLLI---- 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 482 nedimknekdlTFYYliKARGSIFNLGSHVLSLEQGNMKG---VFSLPiqVEPGMAPEAQLLIYAILPNEELVADA---- 554
Cdd:COG2373 746 -----------QSPF--AGRALVTVERDGVLETQWVDVKGggtTVEIP--VTEDWAPNAYVSATLVRPGDSTANDMpara 810
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 555 ---QNFEIEKCfANKVNLSF-PSAQSLPASDTHLKVKAAPLSLCA----LTAVDQSVLLLKPEAKLSPQsiynllpgktv 626
Cdd:COG2373 811 ygvAPLPVDPP-ARRLKVELtAPEKLRPGETLTVTVKVKGAAGKAaevtLAAVDEGILNLTGYKTPDPL----------- 878
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 627 qGAFFGvpvykdhencisgedithngivytpKHSLGDnDAHSIFQSVginiftnskihkprfcqefqhYPAMGGvapqAL 706
Cdd:COG2373 879 -DFFYG-------------------------KRALGV-ETRDLYGRL---------------------IGAFGG----AA 906
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 707 AVAASGpgssframGVPMMGLDysdeinqvvEVRETVRKYFPETWIWD-LVPLDVSGDGELAVKVPDTITEWKASAFCLS 785
Cdd:COG2373 907 GALRSG--------GDGALGRG---------GNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS 969
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 786 GTtGLGlSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVDLEISPDFlaVPVGGHENSHCICGNER 865
Cdd:COG2373 970 DD-RFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEATQTVTLAAGGR 1045
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 866 KTVSWAVTPKSLGEVNFTATAEAlqspelcGNKltevpalvhKDTVVKSVIVEPEGIEKEQTYNTLLCPQDTELQDnwsL 945
Cdd:COG2373 1046 ATVRFPLKAPDAGDAKVTVTATG-------GGE---------SDAREVELPVRPANPLVTRATSGVLAPGESWTLP---L 1106
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 946 ELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNyLNETQQLTEAIKSKAINYLISGYQ 1025
Cdd:COG2373 1107 DLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1026 RQLNYQHSDGSYSTFgnhgGGNTPGNTWLTAFVLKAFAQAQSH-IFIEKTHITNAFNWLSMKQKENGcfqqsgyllnnAM 1104
Cdd:COG2373 1186 RLLSMQNSDGGFGLW----PGGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW-----------EI 1250
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1105 KGGVDDEVTLSAYITIALLEMPLPVTHSAvrNALFCLETAWAS-ISQSQESHVYtkallayafALAGNKAKRSELLESLN 1183
Cdd:COG2373 1251 EYDDAYRLAVRAYALYVLARAGKADLGDL--RYLYDRRKDALSpLAKAQLAAAL---------ALLGDKARAEELLAAAL 1319
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1184 KDAVKEEDSLHWqrpgdvqkvkaLSFYqprapSAEVEMTAYVLLAYLTSESSRPTRDlsssdlstasKIVKWISKQQNSh 1263
Cdd:COG2373 1320 ARLRETGARDYW-----------YGDY-----GSPLRDQALALALLAELGPDAPLAP----------KLARWLAKALKS- 1372
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 1264 GGFSSTQDTVVALQALSKYGAAtfTRSQKEVLVTIESSGtfsKTFHVNSGNRLLLQEVRLPDLPGNYVT-KGSGSGCVYL 1342
Cdd:COG2373 1373 GRWLSTQETAWALLALAAYARA--AGASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELLAGPLTiTNTGDGPLYY 1447
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110347469 1343 QTSLKY--NILPVADGKAPFALQVNTLPLNFD-------KAGDhrTFQIRINVSyTGERPSSNMVIVD 1401
Cdd:COG2373 1448 TLTLSGypAEGPPPAASNGLEIERRYYDLDGKpidpaslKQGD--LVVVRLTVT-APSGRVENVAVVD 1512
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
458-606 |
3.65e-30 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 116.68 E-value: 3.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 458 IQLELVFGTLACGQTQEIRIHYLLNEDIMKNEkdltFYYLIKARGSIfnlgshvlsLEQGNMKGVFSLPIQVEPGMAPEA 537
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDG----FTYLVLSKGQI---------VVVGRGGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110347469 538 QLLIYAI---LPNEELVADAQNFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALTAVDQSVLLL 606
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
349-443 |
3.50e-27 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 106.57 E-value: 3.50e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 349 LKFTKVNTNYRPGLPFSGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEHGLANISIDTSNFTAPfLRVVVTYKQNH 428
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPGNAAS-LSITVKTKDPD 79
|
90
....*....|....*
gi 110347469 429 VCYDNWWLDEFHTQA 443
Cdd:pfam17789 80 LCPEHQALAEMYAEA 94
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
127-219 |
2.34e-25 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 101.24 E-value: 2.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 127 VFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETFPVVYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEPALGIYKVVVQ 206
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 110347469 207 K-DSGKKIEHSFEV 219
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
221-312 |
3.67e-22 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 91.95 E-value: 3.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347469 221 EYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGLVTLRVCRKYSrYRSTCHnqnsmsicEEFSQQADDKGCFR 300
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-SKRKCF--------ESFSKELDKDGCGS 71
|
90
....*....|..
gi 110347469 301 QVVKTKVFQLRQ 312
Cdd:pfam17791 72 ASLSTEEFQLTF 83
|
|
| |
