|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
499-809 |
1.31e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 499 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 578
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 579 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 655
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 656 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 735
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6681049 736 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
354-438 |
7.45e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.18 E-value: 7.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 354 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 432
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 6681049 433 EYTWTT 438
Cdd:cd00063 88 SVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
137-225 |
7.21e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
:
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.13 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 137 PPPPKDIHISP-SGDHFLLEWSVSLGDSQVSwlssKDIEFEVAYKRLQDSWEDASSLHTSNFQV--NLEPklflpNSIYA 213
Cdd:smart00060 1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSSTSYTltGLKP-----GTEYE 71
|
90
....*....|..
gi 6681049 214 ARVRTRLSAGSS 225
Cdd:smart00060 72 FRVRAVNGAGEG 83
|
|
| FN3 super family |
cl21522 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
246-328 |
1.09e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
The actual alignment was detected with superfamily member pfam09067:
Pssm-ID: 473895 Cd Length: 104 Bit Score: 39.33 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 246 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 325
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 6681049 326 SVK 328
Cdd:pfam09067 86 TVV 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
499-809 |
1.31e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 499 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 578
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 579 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 655
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 656 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 735
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6681049 736 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
550-809 |
4.15e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.08 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 550 PPSRPDTT--PAASSESTEQLPNVQVEGPIPSSRPRKQLPSfdfngPYLGPPQSHSLPDLPGQLG----SPQVGGSLKPA 623
Cdd:pfam03154 217 PPNQTQSTaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPP-----PSQVSPQPLPQPSLHGQMPpmphSLQTGPSHMQH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 624 LPGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENP--PVELSVEKQEArdnPMTLPISSGGP 701
Cdd:pfam03154 292 PVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHIKP---PPTTPIPQLPN 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 702 EGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAA 776
Cdd:pfam03154 369 PQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHP 448
|
250 260 270
....*....|....*....|....*....|....*
gi 6681049 777 TSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 809
Cdd:pfam03154 449 PTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
354-438 |
7.45e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.18 E-value: 7.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 354 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 432
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 6681049 433 EYTWTT 438
Cdd:cd00063 88 SVTVTT 93
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
341-436 |
1.75e-04 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 41.56 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 341 HIQMEPPILNQTKNrdsyslhWETQKIpkYIDHTFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCarVRVKPI 420
Cdd:pfam09294 18 NVTVKDPETREGKN-------LSLRDL--YGSLQYRVSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYC--VSVQAF 84
|
90
....*....|....*....
gi 6681049 421 SDYD---GIWSEWSNEYTW 436
Cdd:pfam09294 85 SPLDnksSQRSPPQCIRTT 103
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
137-225 |
7.21e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.13 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 137 PPPPKDIHISP-SGDHFLLEWSVSLGDSQVSwlssKDIEFEVAYKRLQDSWEDASSLHTSNFQV--NLEPklflpNSIYA 213
Cdd:smart00060 1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSSTSYTltGLKP-----GTEYE 71
|
90
....*....|..
gi 6681049 214 ARVRTRLSAGSS 225
Cdd:smart00060 72 FRVRAVNGAGEG 83
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
246-328 |
1.09e-03 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 39.33 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 246 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 325
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 6681049 326 SVK 328
Cdd:pfam09067 86 TVV 88
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
354-418 |
4.42e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 37.21 E-value: 4.42e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6681049 354 NRDSYSLHWETQKIP---KYIDHtFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCARVRVK 418
Cdd:smart00060 13 TSTSVTLSWEPPPDDgitGYIVG-YRVEYREEGSEWK--EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
499-809 |
1.31e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 499 PGSMAAFATKNPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPnvqveGPIP 578
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD-----PHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 579 SSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSlKPALP---GSLEYMCLPPGGQVQLVPLSQVMGQGQAMD 655
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 656 VQCGSSLETTGSPSVEPKENPPVELSVekQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 735
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6681049 736 PSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAATSPPGHPAPPVASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
550-809 |
4.15e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.08 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 550 PPSRPDTT--PAASSESTEQLPNVQVEGPIPSSRPRKQLPSfdfngPYLGPPQSHSLPDLPGQLG----SPQVGGSLKPA 623
Cdd:pfam03154 217 PPNQTQSTaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPP-----PSQVSPQPLPQPSLHGQMPpmphSLQTGPSHMQH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 624 LPGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENP--PVELSVEKQEArdnPMTLPISSGGP 701
Cdd:pfam03154 292 PVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHIKP---PPTTPIPQLPN 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 702 EGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAA 776
Cdd:pfam03154 369 PQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHP 448
|
250 260 270
....*....|....*....|....*....|....*
gi 6681049 777 TSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 809
Cdd:pfam03154 449 PTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
354-438 |
7.45e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.18 E-value: 7.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 354 NRDSYSLHWETQKIPKYIDHTFQVQYKKKSES-WKDSKTENlGRVNSMDLPQLEPDTSYCARVRVKpisdYDGIWSEWSN 432
Cdd:cd00063 13 TSTSVTLSWTPPEDDGGPITGYVVEYREKGSGdWKEVEVTP-GSETSYTLTGLKPGTEYEFRVRAV----NGGGESPPSE 87
|
....*.
gi 6681049 433 EYTWTT 438
Cdd:cd00063 88 SVTVTT 93
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-810 |
5.39e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.24 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 551 PSRPDTTPAASSESTEQLPNVQveGPIPSSRPRKQLPSFDFN-GPYLGPPQSHSLPDLPGQLGSPQvggslKPALPGSLE 629
Cdd:PHA03247 2683 PRRRAARPTVGSLTSLADPPPP--PPTPEPAPHALVSATPLPpGPAAARQASPALPAAPAPPAVPA-----GPATPGGPA 2755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 630 YMCLPP---GGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENPPVELSVEKQEARDNPMTLPIS-SGGPEGSM 705
Cdd:PHA03247 2756 RPARPPttaGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGpLPPPTSAQ 2835
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 706 MASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVP-------------SGSPALGPPGFEdyvelPPSV 772
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPpvrrlarpavsrsTESFALPPDQPE-----RPPQ 2910
|
250 260 270
....*....|....*....|....*....|....*...
gi 6681049 773 SQAATSPPGHPAPPVASSPTVIPGEPREEVGPASPHPE 810
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
498-807 |
1.66e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 498 PPGSMAAFATKNPALQGPQSRLLAEQQGVSyehlednnVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNVQVEGPI 577
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATP--------LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 578 PSSRPRKQLPSfdfnGPYLGPPQShsLPDLPGQLGSPQVGGSLKPALPGSLEYMCLPPGGQVqlvPLSQVMGQGQAMdvq 657
Cdd:PHA03247 2763 TAGPPAPAPPA----APAAGPPRR--LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL---PPAASPAGPLPP--- 2830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 658 cgsslETTGSPSVEPKENPPVE--LSVEKQEARDNPmtlpISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL 735
Cdd:PHA03247 2831 -----PTSAQPTAPPPPPGPPPpsLPLGGSVAPGGD----VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP 2901
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 736 PSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAATSPPGHPAPPVASSPTV--------IPGE---PREEVGP 804
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVpqpwlgalVPGRvavPRFRVPQ 2981
|
...
gi 6681049 805 ASP 807
Cdd:PHA03247 2982 PAP 2984
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
341-436 |
1.75e-04 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 41.56 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 341 HIQMEPPILNQTKNrdsyslhWETQKIpkYIDHTFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCarVRVKPI 420
Cdd:pfam09294 18 NVTVKDPETREGKN-------LSLRDL--YGSLQYRVSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYC--VSVQAF 84
|
90
....*....|....*....
gi 6681049 421 SDYD---GIWSEWSNEYTW 436
Cdd:pfam09294 85 SPLDnksSQRSPPQCIRTT 103
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
612-803 |
2.11e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 45.06 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 612 GSPQVGGSLKPALpgSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENPpvelSVEKQEARDNP 691
Cdd:PRK14959 338 GQRRVLTSLEPAM--ALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTP----GTQGPQGTAPA 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 692 MTLPISSGGPeGSMMASDYVTPGDPVLTLPTGPlstslgPSLGLPSAQSPslclklpRVPSGSPALGPPGfedyvelppS 771
Cdd:PRK14959 412 AGMTPSSAAP-ATPAPSAAPSPRVPWDDAPPAP------PRSGIPPRPAP-------RMPEASPVPGAPD---------S 468
|
170 180 190
....*....|....*....|....*....|..
gi 6681049 772 VSQAATSPPGHPAPPVASSPTviPGEPREEVG 803
Cdd:PRK14959 469 VASASDAPPTLGDPSDTAEHT--PSGPRTWDG 498
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
544-807 |
3.15e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.93 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 544 PNIIRDP----PSRPDTTPAASSESTEQLPNVQVEGPIPssrPR--------KQLPSFDFNGPylgppqshsLPDLPGQL 611
Cdd:PHA03247 2492 AGAAPDPggggPPDPDAPPAPSRLAPAILPDEPVGEPVH---PRmltwirglEELASDDAGDP---------PPPLPPAA 2559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 612 GSPQVGGSLKPALPGSLeymclPPGGQVQL------VPLSQVMGQ--GQAMDVQCGSSLETTGSPSVEPKENPPVELSVE 683
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPR-----PSEPAVTSrarrpdAPPQSARPRapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA 2634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 684 KQEArDNPMTLPISSGGPEGSMMASDYVTPGDPVLTL--PTGPLSTSLGPSL-GLPSAQSPSLCLKLPRVPSGSPALGPP 760
Cdd:PHA03247 2635 ANEP-DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgrAAQASSPPQRPRRrAARPTVGSLTSLADPPPPPPTPEPAPH 2713
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 6681049 761 GFEDYVELPPSVSQAATSPPGHP---APPVASSPTVIPGEPREEVGPASP 807
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPaapAPPAVPAGPATPGGPARPARPPTT 2763
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
665-807 |
4.77e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.92 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 665 TGSPSV--EPKENPPVELSVEKQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPs 742
Cdd:PRK10263 368 TGEPVIapAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA- 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6681049 743 lclkLPRVPSGSPALGPPGFEDYVELPPSVSQAatsPPGHPAPPVASSPTVIPGEPREEVGPASP 807
Cdd:PRK10263 447 ----WQAEEQQSTFAPQSTYQTEQTYQQPAAQE---PLYQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
137-225 |
7.21e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.13 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 137 PPPPKDIHISP-SGDHFLLEWSVSLGDSQVSwlssKDIEFEVAYKRLQDSWEDASSLHTSNFQV--NLEPklflpNSIYA 213
Cdd:smart00060 1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSSTSYTltGLKP-----GTEYE 71
|
90
....*....|..
gi 6681049 214 ARVRTRLSAGSS 225
Cdd:smart00060 72 FRVRAVNGAGEG 83
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
246-328 |
1.09e-03 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 39.33 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 246 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEkCsPVVKEPQASVYTRYRCSLPVPEPSAHSQYTV 325
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-C-PLYSTSGANSTRLFICFFPKNDVSLFVPLHI 85
|
...
gi 6681049 326 SVK 328
Cdd:pfam09067 86 TVV 88
|
|
| IL6Ra-bind |
pfam09240 |
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ... |
251-316 |
2.41e-03 |
|
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.
Pssm-ID: 401252 Cd Length: 96 Bit Score: 38.16 E-value: 2.41e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6681049 251 NLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPAAPEEKCSpvvkEPQASVYTRYRCSLPVPE 316
Cdd:pfam09240 1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQ----YYIRDDGTRIGCQFDDLE 62
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
354-418 |
4.42e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 37.21 E-value: 4.42e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6681049 354 NRDSYSLHWETQKIP---KYIDHtFQVQYKKKSESWKdsKTENLGRVNSMDLPQLEPDTSYCARVRVK 418
Cdd:smart00060 13 TSTSVTLSWEPPPDDgitGYIVG-YRVEYREEGSEWK--EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
535-807 |
5.78e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.54 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 535 NVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNvQVEGPIPSSRPRKQLPsfdfngpyLGPPQSHSlPDLPGQLGSP 614
Cdd:PHA03307 72 PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT-PPGPSSPDPPPPTPPP--------ASPPPSPA-PDLSEMLRPV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 615 QVGGSLKPALPgsleymclPPGGQVQLVPLSQVMGQGQAMDVQcgSSLETTGSPSVEPKENPPVELSVEKQEARDNPMTL 694
Cdd:PHA03307 142 GSPGPPPAASP--------PAAGASPAAVASDAASSRQAALPL--SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 695 PISSGGPEGSMM----------------------------ASDYVTPGDPVLTLPT------GPLSTSLGPSLGLPSAQS 740
Cdd:PHA03307 212 PISASASSPAPApgrsaaddagasssdssssessgcgwgpENECPLPRPAPITLPTriweasGWNGPSSRPGPASSSSSP 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6681049 741 PSLCLK-LPRVPSGSPALGPPGFEDYVELPPSVSQAATS--------PPGHPAPPVASSPTviPGEPREEVGPASP 807
Cdd:PHA03307 292 RERSPSpSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSsssessrgAAVSPGPSPSRSPS--PSRPPPPADPSSP 365
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
345-438 |
6.22e-03 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 37.00 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 345 EPPILNQTKNRDSYSLHWETQKIPKYIdhtfQVQYKKKSESWK----------DSKTENLGRVNSMDLPQLEPDTSYCAR 414
Cdd:pfam16656 2 EQVHLSLTGDSTSMTVSWVTPSAVTSP----VVQYGTSSSALTstatatsstyTTGDGGTGYIHRATLTGLEPGTTYYYR 77
|
90 100
....*....|....*....|....
gi 6681049 415 VRvkpisDYDGIWSEWsneYTWTT 438
Cdd:pfam16656 78 VG-----DDNGGWSEV---YSFTT 93
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
532-808 |
6.85e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.15 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 532 EDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTEQLPNVQVEGPIPSSRPRKQ----LPSFDFNGPYLGPPQSHSLPDL 607
Cdd:PHA03307 29 GDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANesrsTPTWSLSTLAPASPAREGSPTP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 608 PGQLGSPQVGGSLKPALPGSLEymclPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKE-NPPVELSVEKQE 686
Cdd:PHA03307 109 PGPSSPDPPPPTPPPASPPPSP----APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSPEETAR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6681049 687 ARDNPM-TLPISSGGPEGSmmasdyvtPGDPVLTLPTGPLSTSLGPSLG------LPSAQSPSLCLKLPRVPSGSPALGP 759
Cdd:PHA03307 185 APSSPPaEPPPSTPPAAAS--------PRPPRRSSPISASASSPAPAPGrsaaddAGASSSDSSSSESSGCGWGPENECP 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 6681049 760 PGFEDYVELPPSVSQAATSPPGHPAPPVASSPTVIPgEPREEVGPASPH 808
Cdd:PHA03307 257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR-ERSPSPSPSSPG 304
|
|
| |
