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Conserved domains on  [gi|6678734|ref|NP_032547|]
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leukotriene C4 synthase isoform 1 [Mus musculus]

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein similar to mammalian prostaglandin E synthase and leukotriene C4 synthase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-124 5.23e-09

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 51.14  E-value: 5.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678734      8 LATVTLVGVLLQAYFSLQVISARRAFHV--------SPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHE-GA 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6678734     79 AALCGLFYLFARLRYFQGYARS-AQLRLTPLYASARALWLLVAMAAL 124
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGnPPLRSLGFLLGFLALLALAVLALL 127
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-124 5.23e-09

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 51.14  E-value: 5.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678734      8 LATVTLVGVLLQAYFSLQVISARRAFHV--------SPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHE-GA 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6678734     79 AALCGLFYLFARLRYFQGYARS-AQLRLTPLYASARALWLLVAMAAL 124
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGnPPLRSLGFLLGFLALLALAVLALL 127
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
9-133 3.49e-08

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 49.08  E-value: 3.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678734    9 ATVTLVGVLLQAYFSLQVISARRAFHVSPPlTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIffhEGAAA----LCGL 84
Cdd:COG3788   7 ALYAALLALLLLVLSLRVVRLRRKYRVALG-DGGDPELQRAIRAHGNFVEYVPLALILLLLLEL---NGAPAwwlhLLGI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6678734   85 FYLFARLRYFQGYARSAqlRLTPLYASARAL-WLLVAMAALGLLVHFLPG 133
Cdd:COG3788  83 ALLLGRLLHAYGLSRSK--GPSPGRAIGMLLtFLVLLALAVLLLVYLLGG 130
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 8-124 5.23e-09

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 51.14  E-value: 5.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678734      8 LATVTLVGVLLQAYFSLQVISARRAFHV--------SPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHE-GA 78
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6678734     79 AALCGLFYLFARLRYFQGYARS-AQLRLTPLYASARALWLLVAMAAL 124
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGnPPLRSLGFLLGFLALLALAVLALL 127
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
9-133 3.49e-08

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 49.08  E-value: 3.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678734    9 ATVTLVGVLLQAYFSLQVISARRAFHVSPPlTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIffhEGAAA----LCGL 84
Cdd:COG3788   7 ALYAALLALLLLVLSLRVVRLRRKYRVALG-DGGDPELQRAIRAHGNFVEYVPLALILLLLLEL---NGAPAwwlhLLGI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6678734   85 FYLFARLRYFQGYARSAqlRLTPLYASARAL-WLLVAMAALGLLVHFLPG 133
Cdd:COG3788  83 ALLLGRLLHAYGLSRSK--GPSPGRAIGMLLtFLVLLALAVLLLVYLLGG 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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