|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1241 |
1.50e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 447.80 E-value: 1.50e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 960 AIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK------------------------- 1094
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQggvddevaltayvlialleaglpse 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1095 HPVVSKALSCLESSWKTIeqgrnaNFVYTKALMAYAFALAGnQDKRNEILKSLDEEAIKEDNSIHWERPqkPRKSEHNLY 1174
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153945747 1175 KPQASSVEVEMNAYVVLARLTAQpapsPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1241
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
1.32e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 136.18 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 740 TWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 153945747 820 LPTSMRMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
99-1307 |
6.48e-35 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 145.99 E-value: 6.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 99 EEEFLYVDIK-GPTHEFSKRN-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELlPL-AYIEDP--KKN 173
Cdd:COG2373 339 GGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgKEV 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 174 RIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKQSGVKE-EHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCG 252
Cdd:COG2373 418 RRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDA 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 253 KYTYGKPVPG-----QVKISICHETEAGCK-----------------EVNSKLDNNGCSTQEVNITELQSKKRNYEVQlf 310
Cdd:COG2373 496 RYLFGAPAAGlkvegEVTLRPARTAFPGYPgyrfgdpdeefepeeldLGEGTLDADGKASLSLPLPDAPDAPGPLRAT-- 573
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 311 hVNATVTEEGtGLEFNGYGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTSATT 388
Cdd:COG2373 574 -VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWY 650
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 389 TDQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSC------------------------YFFYCMEERYASAEHVAYAVYSL 444
Cdd:COG2373 651 KSDDGGWRYESQEKEEPVAEGTLTTGADGPASLsltpvewgryrlevkdpdgglatsVRFYAGGNASWGAERPDRLELSL 730
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 445 SKSYiYLVKETSSILpcnqihtVQAHFILKGdlgvlkelvfyyLVMAQGS-IIQTgnHTHQVEPGEApvkgnfDLEIPVE 523
Cdd:COG2373 731 DKES-YKPGETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGT------TVEIPVT 782
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 524 FSMAPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLSFSSSQSL-PASQTRLQVTASPQSlcG--- 588
Cdd:COG2373 783 EDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA--Gkaa 855
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 589 ---LRAVDQSVLLLKPedelspswiYNLPgmqhnkfipssslsedredcilysswvaekhtDWVPH--GREK------DV 657
Cdd:COG2373 856 evtLAAVDEGILNLTG---------YKTP--------------------------------DPLDFfyGKRAlgvetrDL 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 658 YRYVEDmdlkaftnlkiklpkicfdsaPMSGPRGKfdLAFSSEVSGTLQKGSSKRpqpeeppredpppkdplaetiRKYF 737
Cdd:COG2373 895 YGRLIG---------------------AFGGAAGA--LRSGGDGALGRGGNPKPP---------------------RKRF 930
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 738 PETWVWD-IVTVNSTGVAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATV 816
Cdd:COG2373 931 KPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDV 1008
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 817 MNYLPTSMRMSVQLEASPDFTavPVGDDHDSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQqssepcgsevatvpetG 896
Cdd:COG2373 1009 FNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------G 1070
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 897 RKDTVVKVLIVEPEGIKQEHTFNSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGE 976
Cdd:COG2373 1071 ESDAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTE 1147
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 977 QNMVLFAPNIYVLKyLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARA 1056
Cdd:COG2373 1148 QTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEARE 1223
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1057 F-IFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDI----------KHPVVSKAlsclesswKTIEQGRNANF-VYTK 1124
Cdd:COG2373 1224 AgYAVPDDALDRALDYLRNYLRNPWEIEYDDAYRLAVRayalyvlaraGKADLGDL--------RYLYDRRKDALsPLAK 1295
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1125 ALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERpqkprksehnLYkpqASSVEvemNAYVVLARLTAQPAPSPED 1204
Cdd:COG2373 1296 AQLAAALALLGDKARAEELLAAALARLRETGARDYWYG----------DY---GSPLR---DQALALALLAELGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1205 LTLSRstimWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRRQKTSLVTIQSTGSfSQKFQVENSNCLLLQQVPLPD 1284
Cdd:COG2373 1360 PKLAR----WLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLTGRGPLARVTLPAAE 1429
|
1290 1300
....*....|....*....|....
gi 153945747 1285 I-PGDYTISVSGEGCVYAQTTLRY 1307
Cdd:COG2373 1430 LlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1351-1441 |
9.65e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 119.60 E-value: 9.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1351 PASNMVIADVKMLSGFIPLKPTVKKLERLEHISRTE-VSNNNVLLYLDQVTNQTLAFSFIIQQDISVRNLQPAIVKVYDY 1429
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 153945747 1430 YETDEVAYAEYS 1441
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1241 |
1.50e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 447.80 E-value: 1.50e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 960 AIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK------------------------- 1094
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQggvddevaltayvlialleaglpse 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1095 HPVVSKALSCLESSWKTIeqgrnaNFVYTKALMAYAFALAGnQDKRNEILKSLDEEAIKEDNSIHWERPqkPRKSEHNLY 1174
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153945747 1175 KPQASSVEVEMNAYVVLARLTAQpapsPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1241
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
950-1241 |
4.61e-141 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 434.03 E-value: 4.61e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 950 FSVMGDILSSAIK----NTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDG 1025
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1026 SYSAFGDqngeREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK----------- 1094
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKggvdgevslta 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1095 -------------------HPVVSKALSCLESswktiEQGRNANFVYTKALMAYAFALAGNQDKRNEILKSLDEEAIKED 1155
Cdd:pfam07678 157 yvtiallealdingllqrvHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1156 NSIHWERPQKPRKSEHNLYKPQASSVEVEMNAYVVLARLtaqpapSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVAL 1235
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 153945747 1236 DALSKY 1241
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
1.32e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 136.18 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 740 TWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 153945747 820 LPTSMRMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
99-1307 |
6.48e-35 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 145.99 E-value: 6.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 99 EEEFLYVDIK-GPTHEFSKRN-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELlPL-AYIEDP--KKN 173
Cdd:COG2373 339 GGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgKEV 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 174 RIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKQSGVKE-EHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCG 252
Cdd:COG2373 418 RRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDA 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 253 KYTYGKPVPG-----QVKISICHETEAGCK-----------------EVNSKLDNNGCSTQEVNITELQSKKRNYEVQlf 310
Cdd:COG2373 496 RYLFGAPAAGlkvegEVTLRPARTAFPGYPgyrfgdpdeefepeeldLGEGTLDADGKASLSLPLPDAPDAPGPLRAT-- 573
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 311 hVNATVTEEGtGLEFNGYGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTSATT 388
Cdd:COG2373 574 -VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWY 650
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 389 TDQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSC------------------------YFFYCMEERYASAEHVAYAVYSL 444
Cdd:COG2373 651 KSDDGGWRYESQEKEEPVAEGTLTTGADGPASLsltpvewgryrlevkdpdgglatsVRFYAGGNASWGAERPDRLELSL 730
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 445 SKSYiYLVKETSSILpcnqihtVQAHFILKGdlgvlkelvfyyLVMAQGS-IIQTgnHTHQVEPGEApvkgnfDLEIPVE 523
Cdd:COG2373 731 DKES-YKPGETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGT------TVEIPVT 782
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 524 FSMAPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLSFSSSQSL-PASQTRLQVTASPQSlcG--- 588
Cdd:COG2373 783 EDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA--Gkaa 855
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 589 ---LRAVDQSVLLLKPedelspswiYNLPgmqhnkfipssslsedredcilysswvaekhtDWVPH--GREK------DV 657
Cdd:COG2373 856 evtLAAVDEGILNLTG---------YKTP--------------------------------DPLDFfyGKRAlgvetrDL 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 658 YRYVEDmdlkaftnlkiklpkicfdsaPMSGPRGKfdLAFSSEVSGTLQKGSSKRpqpeeppredpppkdplaetiRKYF 737
Cdd:COG2373 895 YGRLIG---------------------AFGGAAGA--LRSGGDGALGRGGNPKPP---------------------RKRF 930
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 738 PETWVWD-IVTVNSTGVAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATV 816
Cdd:COG2373 931 KPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDV 1008
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 817 MNYLPTSMRMSVQLEASPDFTavPVGDDHDSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQqssepcgsevatvpetG 896
Cdd:COG2373 1009 FNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------G 1070
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 897 RKDTVVKVLIVEPEGIKQEHTFNSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGE 976
Cdd:COG2373 1071 ESDAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTE 1147
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 977 QNMVLFAPNIYVLKyLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARA 1056
Cdd:COG2373 1148 QTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEARE 1223
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1057 F-IFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDI----------KHPVVSKAlsclesswKTIEQGRNANF-VYTK 1124
Cdd:COG2373 1224 AgYAVPDDALDRALDYLRNYLRNPWEIEYDDAYRLAVRayalyvlaraGKADLGDL--------RYLYDRRKDALsPLAK 1295
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1125 ALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERpqkprksehnLYkpqASSVEvemNAYVVLARLTAQPAPSPED 1204
Cdd:COG2373 1296 AQLAAALALLGDKARAEELLAAALARLRETGARDYWYG----------DY---GSPLR---DQALALALLAELGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1205 LTLSRstimWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRRQKTSLVTIQSTGSfSQKFQVENSNCLLLQQVPLPD 1284
Cdd:COG2373 1360 PKLAR----WLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLTGRGPLARVTLPAAE 1429
|
1290 1300
....*....|....*....|....
gi 153945747 1285 I-PGDYTISVSGEGCVYAQTTLRY 1307
Cdd:COG2373 1430 LlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1351-1441 |
9.65e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 119.60 E-value: 9.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1351 PASNMVIADVKMLSGFIPLKPTVKKLERLEHISRTE-VSNNNVLLYLDQVTNQTLAFSFIIQQDISVRNLQPAIVKVYDY 1429
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 153945747 1430 YETDEVAYAEYS 1441
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
459-599 |
2.95e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.98 E-value: 2.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 459 LPCNQIHTVQAHFILKGDlgVLKElVFYYLVMAQGSIIQTGNHTHQVEpgeapvkgnfdLEIPVEFSMAPMAKMLIYTI- 537
Cdd:pfam07703 10 YKPGETATVTVKSPFDGT--VERD-GFTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAPSARVVAYYVr 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153945747 538 --LPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLL 599
Cdd:pfam07703 76 vdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1241 |
1.50e-146 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 447.80 E-value: 1.50e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 960 AIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK------------------------- 1094
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQggvddevaltayvlialleaglpse 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1095 HPVVSKALSCLESSWKTIeqgrnaNFVYTKALMAYAFALAGnQDKRNEILKSLDEEAIKEDNSIHWERPqkPRKSEHNLY 1174
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153945747 1175 KPQASSVEVEMNAYVVLARLTAQpapsPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1241
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
950-1241 |
4.61e-141 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 434.03 E-value: 4.61e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 950 FSVMGDILSSAIK----NTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDG 1025
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1026 SYSAFGDqngeREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK----------- 1094
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKggvdgevslta 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1095 -------------------HPVVSKALSCLESswktiEQGRNANFVYTKALMAYAFALAGNQDKRNEILKSLDEEAIKED 1155
Cdd:pfam07678 157 yvtiallealdingllqrvHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1156 NSIHWERPQKPRKSEHNLYKPQASSVEVEMNAYVVLARLtaqpapSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVAL 1235
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 153945747 1236 DALSKY 1241
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
960-1241 |
4.54e-103 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 330.12 E-value: 4.54e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 960 AIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgerEG 1039
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSD---SG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIK------------------------H 1095
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKggvddsvsltayvlialaeagkacD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1096 PVVSKALSCLESSWKtieqgrNANFVYTKALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERPqkprksehnLYK 1175
Cdd:cd02891 158 ASIEKALAYLETQLD------GLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSLS---------WPG 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153945747 1176 PQASSVEVEMNAYVVLARLtaqpapSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1241
Cdd:cd02891 223 DYGSSLRVEATAYALLALL------KLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
961-1241 |
3.66e-73 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 246.03 E-value: 3.66e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 961 IKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQ---KIKTKALGFLRAGYQRELNYKHKDGSYSAFGDqngeR 1037
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKlgpERRDEALKYIRQGYQRQLSYRKPDGSYAAWKN----R 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1038 EGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIKHPV------VS----------KA 1101
Cdd:cd02896 78 PSSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsegdVSltafvlialqEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1102 LSCLESSWKTIEQGRN--ANF----------VYTKALMAYAFALAGNQDKR--NEILKSLdeeAIKEDNSIHWERPQKPr 1167
Cdd:cd02896 158 RSICPPEVQNLDQSIRkaISYlenqlpnlqrPYALAITAYALALADSPLSHaaNRKLLSL---AKRDGNGWYWWTIDSP- 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153945747 1168 ksehNLYKPQASSVEVEMNAYVVLARLtaqpapSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1241
Cdd:cd02896 234 ----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
960-1241 |
1.71e-58 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 204.32 E-value: 1.71e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 960 AIKNTQNLLHMPYG--------CGEQNMVLFAPNIYVLKYLDKTQqltqkIKTKALGFLRAGYQRELNYKHKDGSYSAFG 1031
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1032 DQNgerEGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDI------------------ 1093
Cdd:cd00688 76 GND---YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIGgdesdvrltayalialal 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1094 -----KHPVVSKALSCLESS--WKTIEQGRNANFVYTKALMAYAFALAG--NQDKRNEILKSLDEEAIKEDNSIHWERpq 1164
Cdd:cd00688 153 lgkldPDPLIEKALDYLLSCqnYDGGFGPGGESHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGRD-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1165 kprksehnLYKPQASSVEVEMNAYVVLARLtaqpapSPEDLTLSRSTIMWLTKQQNSNGGFSS-------TQDTVVALDA 1237
Cdd:cd00688 231 --------RTNKLSDSCYTEWAAYALLALG------KLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLA 296
|
....
gi 153945747 1238 LSKY 1241
Cdd:cd00688 297 LSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
1.32e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 136.18 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 740 TWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 153945747 820 LPTSMRMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
99-1307 |
6.48e-35 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 145.99 E-value: 6.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 99 EEEFLYVDIK-GPTHEFSKRN-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELlPL-AYIEDP--KKN 173
Cdd:COG2373 339 GGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgKEV 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 174 RIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKQSGVKE-EHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCG 252
Cdd:COG2373 418 RRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDA 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 253 KYTYGKPVPG-----QVKISICHETEAGCK-----------------EVNSKLDNNGCSTQEVNITELQSKKRNYEVQlf 310
Cdd:COG2373 496 RYLFGAPAAGlkvegEVTLRPARTAFPGYPgyrfgdpdeefepeeldLGEGTLDADGKASLSLPLPDAPDAPGPLRAT-- 573
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 311 hVNATVTEEGtGLEFNGYGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTSATT 388
Cdd:COG2373 574 -VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRYVWY 650
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 389 TDQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSC------------------------YFFYCMEERYASAEHVAYAVYSL 444
Cdd:COG2373 651 KSDDGGWRYESQEKEEPVAEGTLTTGADGPASLsltpvewgryrlevkdpdgglatsVRFYAGGNASWGAERPDRLELSL 730
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 445 SKSYiYLVKETSSILpcnqihtVQAHFILKGdlgvlkelvfyyLVMAQGS-IIQTgnHTHQVEPGEApvkgnfDLEIPVE 523
Cdd:COG2373 731 DKES-YKPGETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGT------TVEIPVT 782
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 524 FSMAPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLSFSSSQSL-PASQTRLQVTASPQSlcG--- 588
Cdd:COG2373 783 EDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA--Gkaa 855
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 589 ---LRAVDQSVLLLKPedelspswiYNLPgmqhnkfipssslsedredcilysswvaekhtDWVPH--GREK------DV 657
Cdd:COG2373 856 evtLAAVDEGILNLTG---------YKTP--------------------------------DPLDFfyGKRAlgvetrDL 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 658 YRYVEDmdlkaftnlkiklpkicfdsaPMSGPRGKfdLAFSSEVSGTLQKGSSKRpqpeeppredpppkdplaetiRKYF 737
Cdd:COG2373 895 YGRLIG---------------------AFGGAAGA--LRSGGDGALGRGGNPKPP---------------------RKRF 930
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 738 PETWVWD-IVTVNSTGVAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATV 816
Cdd:COG2373 931 KPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDV 1008
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 817 MNYLPTSMRMSVQLEASPDFTavPVGDDHDSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQqssepcgsevatvpetG 896
Cdd:COG2373 1009 FNLTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------G 1070
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 897 RKDTVVKVLIVEPEGIKQEHTFNSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGE 976
Cdd:COG2373 1071 ESDAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTE 1147
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 977 QNMVLFAPNIYVLKyLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARA 1056
Cdd:COG2373 1148 QTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEARE 1223
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1057 F-IFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDI----------KHPVVSKAlsclesswKTIEQGRNANF-VYTK 1124
Cdd:COG2373 1224 AgYAVPDDALDRALDYLRNYLRNPWEIEYDDAYRLAVRayalyvlaraGKADLGDL--------RYLYDRRKDALsPLAK 1295
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1125 ALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERpqkprksehnLYkpqASSVEvemNAYVVLARLTAQPAPSPED 1204
Cdd:COG2373 1296 AQLAAALALLGDKARAEELLAAALARLRETGARDYWYG----------DY---GSPLR---DQALALALLAELGPDAPLA 1359
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1205 LTLSRstimWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRRQKTSLVTIQSTGSfSQKFQVENSNCLLLQQVPLPD 1284
Cdd:COG2373 1360 PKLAR----WLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLTGRGPLARVTLPAAE 1429
|
1290 1300
....*....|....*....|....
gi 153945747 1285 I-PGDYTISVSGEGCVYAQTTLRY 1307
Cdd:COG2373 1430 LlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1351-1441 |
9.65e-32 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 119.60 E-value: 9.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 1351 PASNMVIADVKMLSGFIPLKPTVKKLERLEHISRTE-VSNNNVLLYLDQVTNQTLAFSFIIQQDISVRNLQPAIVKVYDY 1429
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 153945747 1430 YETDEVAYAEYS 1441
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
459-599 |
2.95e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.98 E-value: 2.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 459 LPCNQIHTVQAHFILKGDlgVLKElVFYYLVMAQGSIIQTGNHTHQVEpgeapvkgnfdLEIPVEFSMAPMAKMLIYTI- 537
Cdd:pfam07703 10 YKPGETATVTVKSPFDGT--VERD-GFTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAPSARVVAYYVr 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153945747 538 --LPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLL 599
Cdd:pfam07703 76 vdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
340-434 |
3.54e-26 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 103.87 E-value: 3.54e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 340 LIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTSATTTDQHGLAKFSIDTAGFsGSSLHIKVNHKGKD 419
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPGN-AASLSITVKTKDPD 79
|
90
....*....|....*
gi 153945747 420 SCYFFYCMEERYASA 434
Cdd:pfam17789 80 LCPEHQALAEMYAEA 94
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
223-302 |
5.46e-26 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 102.74 E-value: 5.46e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 223 EFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGKPVPGQVKISICHETEAGCKE---VNSKLDNNGCSTQEVNITELQ 299
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCfesFSKELDKDGCGSASLSTEEFQ 80
|
...
gi 153945747 300 SKK 302
Cdd:pfam17791 81 LTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
129-221 |
3.72e-21 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 89.30 E-value: 3.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945747 129 VFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELLPLAYIEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPYKIVVH 208
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 153945747 209 K-QSGVKEEHSFTV 221
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| |
