Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059482    13 MENDHQKKE-EKEEKPQDTIRREPAVAltsEAGKNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMRE-ENVQRFGG 90
Cdd:pfam04538   1 MEKACQENEgKPEEQGKVENEEEPEDL---EGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 47059482    91 DVRQLMEKLRERQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  78 EMRELRQKLREQQWRQ--------RPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059482    13 MENDHQKKE-EKEEKPQDTIRREPAVAltsEAGKNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMRE-ENVQRFGG 90
Cdd:pfam04538   1 MEKACQENEgKPEEQGKVENEEEPEDL---EGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 47059482    91 DVRQLMEKLRERQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  78 EMRELRQKLREQQWRQ--------RPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059482    13 MENDHQKKE-EKEEKPQDTIRREPAVAltsEAGKNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMRE-ENVQRFGG 90
Cdd:pfam04538   1 MEKACQENEgKPEEQGKVENEEEPEDL---EGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREgDDMERFGE 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 47059482    91 DVRQLMEKLRERQLSHslravstdPPHHDHHDEF 124
Cdd:pfam04538  78 EMRELRQKLREQQWRQ--------RPHRDHHYPF 103