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Conserved domains on  [gi|164698489|ref|NP_033207|]
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alpha-2,8-sialyltransferase 8B isoform 1 precursor [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467715  Cd Length: 278  Bit Score: 613.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSG 170
Cdd:cd23987    1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 171 CGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKE 250
Cdd:cd23987   81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 251 RVEWVNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987  161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 164698489 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987  241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 613.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSG 170
Cdd:cd23987    1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 171 CGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKE 250
Cdd:cd23987   81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 251 RVEWVNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987  161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 164698489 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987  241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 7.48e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 298.75  E-value: 7.48e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  191 EYARDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLHGLNG--SILWIPAFMARGGKERVEWVNALILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 164698489  344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 613.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSG 170
Cdd:cd23987    1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 171 CGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKE 250
Cdd:cd23987   81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 251 RVEWVNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987  161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 164698489 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987  241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 515.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSG 170
Cdd:cd23969    1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 171 CGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKE 250
Cdd:cd23969   81 CGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 251 RVEWVNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23969  161 HVQWTNEIILKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 164698489 331 YYDSLKYGYtsQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23969  241 YYDNRKYLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 91-367 1.35e-174

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 486.77  E-value: 1.35e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSG 170
Cdd:cd23988    1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 171 CGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKE 250
Cdd:cd23988   81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 251 RVEWVNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23988  161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 164698489 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLT 367
Cdd:cd23988  241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLT 277
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 95-368 7.59e-111

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 324.98  E-value: 7.59e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  95 RIRKQILKFLDAEKDISVLKGTlKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQE 174
Cdd:cd23963    5 KFRKELERLLNTRKLFLTQKNT-PLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 175 IDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23963   84 IDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 255 VNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVhIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23963  164 AARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDD 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 164698489 335 LKYGYTSqaSPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23963  243 LSPSTKN--KVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 7.48e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 298.75  E-value: 7.48e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  191 EYARDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLHGLNG--SILWIPAFMARGGKERVEWVNALILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 164698489  344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 89-368 6.29e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 287.37  E-value: 6.29e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  89 NQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMN-VSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLL 167
Cdd:cd23970    2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 168 NSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARG 247
Cdd:cd23970   82 NSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 248 GKERVEWVNALILKH--HVNVRTAYPSlRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQN 325
Cdd:cd23970  162 SATVTRTLVDFFVEHrgQLKVQLAWPG-NIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGT 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 164698489 326 PVKYHYYDSL--KYGYTSQASpHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23970  241 PLPYHYYDKKgtKFTTKWQES-HQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 120-366 1.19e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 219.82  E-value: 1.19e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 120 GDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVqEYARDVGLK 199
Cdd:cd23971   30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 200 TDLVTMNPSVIQRAFEDLVNatWREKLLQRLHGLNGSILWIPAFMARGGKErvewvnalilkhhvnvrtayPSLRLLHAV 279
Cdd:cd23971  109 TNLVTANPSILREKFHNLKK--RRRPFVERMKVYGNALLLLPAFSYTSNTE--------------------PSLRALYTL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 280 R--------------------GYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygy 339
Cdd:cd23971  167 EdfgspqkvlffnpeylrnlsRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL--- 243

                        250       260
                 ....*....|....*....|....*..
gi 164698489 340 tSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23971  244 -PKKGVHAMPEEFLRYLKLHSQGVLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 97-368 5.42e-59

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 192.35  E-value: 5.42e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489  97 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKnKHFQTCAIVGNSGVLLNSGCGQEID 176
Cdd:cd23989    7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 177 THSFVIRCNLAPV-QEYARDVGLKTDLVTMNPSVIQRAFEDLVnatW-REKLLQRLHGLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23989   86 RADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNLL---WsRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 255 VNALILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23989  163 VYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDN 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 164698489 335 LkygyTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23989  243 V----LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 120-366 2.56e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 172.33  E-value: 2.56e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 120 GDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPV-QEYARDVGL 198
Cdd:cd23990   30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 199 KTDLVTMNPSVIQRAFEDLvnATWREKLLQRLHGLNGSILWIPAFMARGGKE---RVEWVnaliLKHHVNVRTAY---Ps 272
Cdd:cd23990  110 KTDVVTINPSIITERFHKL--EKWRRPFYEVLQVYENASVVLPAFYNTRNTDvsiRVKYV----LDDFESQQAVYyfhP- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 273 lRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEF 352
Cdd:cd23990  183 -QYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPSEI 257

                        250
                 ....*....|....
gi 164698489 353 KALKSLHEQGALKL 366
Cdd:cd23990  258 FNFLHMHSRGILRV 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 132-366 8.10e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 168.39  E-value: 8.10e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 132 TMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ-EYARDVGLKTDLVTMNPSVI 210
Cdd:cd23991   42 KILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGgNISKDVGSKTNLVTANPSII 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 211 QRAFEDLVNAtwREKLLQRLHGLNGSILWIPAFMAR----------------GGKERVEWVNALILKHhvnvrtaypslr 274
Cdd:cd23991  122 SIKYAKLNER--RKPFLETVSVYGDAFLLLPAFSYRsntalsfkvyytledfKAKQKVIFFHPIYLKH------------ 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 275 LLHavrgYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSL--KYGYtsqaspHTMPLEF 352
Cdd:cd23991  188 LAQ----FWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQlpKPGF------HSMPKEF 257

                        250
                 ....*....|....
gi 164698489 353 KALKSLHEQGALKL 366
Cdd:cd23991  258 YQLLQLHSKGILKL 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 157-358 3.21e-36

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 130.56  E-value: 3.21e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLlqrlhgLNGS 236
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPL------EEEV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 237 ILWIPAFMARGGKERV-----EWVNALILKHHVNvrtaypslRLLHAVRGYW----LTNKVHIKRPTTGLLMYTLATRFC 307
Cdd:cd19952   75 VLILSRAAAADFKRLKrrkkrHDNAVLLLTDPAP--------DLLSYVRKRLeklgLKSFFGGNAPSSGLLAVLLALQLC 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 164698489 308 NQIYLYGFWPFPLDQNQNPvkYHYYDslKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd19952  147 DSVDLYGFGVDSGHAPKVP--YHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 156-366 2.65e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 103.88  E-value: 2.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 156 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNP-SVIQRAFEDLV---NATW--------- 222
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPeSLHNSLLKHVPqdkDTKYlfipfkird 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 223 REKLLQRLHGLNgsilwIPAFMARGGKERvewvnaLILKHHVNVRTaypsLRLLHA-----VRGYWLtNKVHIKRPTTGL 297
Cdd:cd23964  164 YDYLDAVLSGKP-----VPDGCDKGKRPP------PLFGPKLNATN----VRLLHPdfiryLFNRWL-NSSTSYRPTTGA 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164698489 298 LMYTLATRFCNQIYLYGF---WPFPLdqnqnpvkyHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23964  228 LMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 125-336 3.07e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 103.12  E-value: 3.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 125 YIFDRDST-MNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLV 203
Cdd:cd23968   15 STLRKTTSpFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 204 TMNpSVI----QRAFEDlvnatwreKLLQRlhglNGSIL-WIPAFMARGGKERVEWVNALILKHHVNVRTAYPSLRL-LH 277
Cdd:cd23968   95 LIN-SQIlskpEFNFLT--------DPLYR----NVTLLvWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFyLI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164698489 278 AVRGYW-------LTNKVHIKR--PTTGLLMYTLATRFCNQIYLYGFWPfPLDQNQnpvKYHYYDSLK 336
Cdd:cd23968  162 DPRFLWrlwdilqEYTPEKIKPnpPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTD---RCHYYDVEK 225
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 134-366 1.18e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 87.72  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 134 NVSQNLYELLPRTSPLKNK---HFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSvi 210
Cdd:cd23966   54 EVLEKLFQVVPGENPYRTRdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPE-- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 211 qrAFEDLVNAT-------------WrekLLQRLHglNGSILW----IPAFMaRGGKERVEWVN-ALIlkHHVNVRtayps 272
Cdd:cd23966  132 --SAVDLDPGVhlvlvpfkvldlqW---LISALT--TGEITRtytpVKRFI-KADKDKVLVINpAFI--KYVHDN----- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 273 lrllhavrgyWLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHTMPLE 351
Cdd:cd23966  197 ----------WTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGN--WHHYWEKNRSaGAFRKTGVHDADFE 259

                        250
                 ....*....|....*
gi 164698489 352 FKALKSLHEQGALKL 366
Cdd:cd23966  260 SDIIKKLAKEGKIRV 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-335 1.32e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 86.85  E-value: 1.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 148 PLKnKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDlvnatwREKLL 227
Cdd:cd23976   10 PLK-MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRN------RNELL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 228 QRLHGlNGSILWIPA-FMARGGKERVewVNALILKHHVnvrtaYPSLRLLHAVRGYWLTNKVHIKRPT------------ 294
Cdd:cd23976   83 NVSQG-TVFIFWGPSnYMRRDGKGLV--YNNLQLMNQI-----LPKLKVYTITRHKMLQFDELFKRETgkdrkisntwls 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 164698489 295 TGLLMYTLATRFCNQIYLYGFWP--FPLDQNQNPVKYHYYDSL 335
Cdd:cd23976  155 TGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 155-358 2.82e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 85.10  E-value: 2.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 155 QTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPsviQRAFEDLVNATWREKLLQRLHGLN 234
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYP---ESAQFDPGIENDPDTLLVLVPFKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 235 GSILWIPAFMARGGKERVEWVNALILKHHVN---VRTAYP------SLRLLHaVRGywltNKVHIKRPTTGLLMYTLATR 305
Cdd:cd23982   80 LDFYWLYEILSNEKRVRKGFWKQPPRIWDANpkqIRILNPyytyvaATKLLQ-VPG----QRKKKQKPTTGLLAITLALH 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 164698489 306 FCNQIYLYGFwPFPLDQNQN-PVkyHYYDslkyGYTS---QASPHTMPLEFKALKSL 358
Cdd:cd23982  155 LCDEVHIAGF-GYPDNGNSNqPI--HYYN----QITLksmANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 157-358 1.43e-18

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 83.11  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNP-SVIQRAFEDLVNAT------------WR 223
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPeSAFRDPEEYDSDWLlvlvpfksmdllWL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 224 EKLLQRlHGLNGSILWI--PAFMARGGKERVEWVNALILKhhvnvRTAYPSLRLLHAvrgywltNKVHIKRPTTGLLMYT 301
Cdd:cd23967   85 QAVIKG-KKPNGKGGFWkkIATSVPKPPKKIRILNPYILQ-----EAAFDLIGLPMN-------GKQGKNVPTTGIIAIV 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 164698489 302 LATRFCNQIYLYGFwPFPLDQNQNPvkYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23967  152 MALHYCDEVDIAGF-GYDPSDPNAP--LHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 152-334 4.19e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.44  E-value: 4.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 152 KHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVI---QRAFedLVNATWREKLLq 228
Cdd:cd23985   43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVtteKHKF--LKDSLYNEGIL- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 229 rlhglngsILWIPAFMArggKERVEWVNalilKHHVNVRTAYPSLRLLHAVRGYWLTNKV---------------HIKR- 292
Cdd:cd23985  120 --------IVWDPAPYH---SDIPEWYK----NPDYNFFENYKTYRRLNPNQPFYILHPQmqwelwdiiqenspeEIQPn 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 164698489 293 -PTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNPVkYHYYDS 334
Cdd:cd23985  185 pPSSGMLGIILMMTLCDQVDVYEFLP---SKRKTDV-CHYYQK 223
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 156-366 4.87e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 72.09  E-value: 4.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 156 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWRekllQRLHGLNG 235
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFK----NIPQDKDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 236 SILWIPAfmargGKERVEWVNALILKHHVN---VRTAYP-----------SLRLLHA-----VRGYWLTNKV------HI 290
Cdd:cd23973  161 KYILFPE-----GPRDYQWLEALLKNKTIPsgaYYGRRPrsyfsgdftedKYLVLHPdflryVKNRFLRSKTlkgkywAI 235

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164698489 291 KRPTTGLLMYTLATRFCNQIYLYGFwpfpldQNQNPVKY--HYYDsLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23973  236 YRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYD-KKKTKLVFYINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 155-337 5.11e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 70.73  E-value: 5.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 155 QTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDL-----VTMnPSVIQRAFEDLVNaTWREKLLqr 229
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIrvvshSSL-PRLLRNAILLLAG-TRAPTVV-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 230 lhglngsILWIPAF-MARGGKERVEWVNALILKH-HVNVRTAYPSlRLLHAVR-------------GYWLtnkvhikrpT 294
Cdd:cd23965   78 -------VFWGPETkMNKDGAGKYNLLRSLSKKYpDVEFYSLTPE-KMDYADElfeketgksriksGTWL---------S 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 164698489 295 TGLLMYTLATRFCNQIYLYGFWP------FPLDQnqnpVKYHYYDSLKY 337
Cdd:cd23965  141 TGWFTMLLALDVCDEIKVYGMVPenycreHPNSK----VPYHYYEPGGL 185
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 127-366 7.90e-14

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 71.06  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 127 FDRDSTMNVSQNLYELLPRTSPLKNK---HFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLV 203
Cdd:cd23979   50 FKPHNTKEVLSKLFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 204 TMNPSVIQRAFEDLVNATWREKLLqrlhglngSILWIPAFMARG---------------GKERVEWVNALILKHhvnvrt 268
Cdd:cd23979  130 FMYPESAKNLPANVSFVLVPFKTL--------DLLWITSALSTGqirftyapvkqflrvDKDKVQIYNPAFFKY------ 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 269 aypslrllhaVRGYWLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHT 347
Cdd:cd23979  196 ----------IHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGN--WHHYWENNRYaGEFRKTGVHD 258

                        250
                 ....*....|....*....
gi 164698489 348 MPLEFKALKSLHEQGALKL 366
Cdd:cd23979  259 ADFEAHIIDMLAKAGKIKV 277
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 156-358 1.00e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 69.39  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 156 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDL--------------VTMNPSVIQRAF--EDLvn 219
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFrlcypesifsdpshYDPNTTVVLIPFkpHDL-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 220 aTWrekLLQRLHGLNGSI--LW-IPAFMARGGKERVEWVNALILKhhvnvRTAYpslRLLHAVRGYWLTNKVhiKRPTTG 296
Cdd:cd23984   82 -RW---LLDLLMGKKVSAkgFWkKPALNLIYKPNQIRILNPFILR-----IAAY---ELLHFPKRFPKEKKP--KHPTTG 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164698489 297 LLMYTLATRFCNQIYLYGFwPFPLDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23984  148 IIAITLALHICNEVHIAGF-KYDFSNLNSTL--HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 157-366 1.28e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.62  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLV-----TMNPSVIqrAFEDL-VNATWREKLLQRL 230
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvnTMKNSLI--SYWNLgFTRTPQGQDLQYI 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 231 H---------GLNGSILWIPafMARGGKERVEWVNALILKHHVN-VRTAYPSlrLLHAVRGYWLTNKV------HIKRPT 294
Cdd:cd23972  163 FipsdirdyvMLRSAILGVP--VPEGLDKGDRPHKYFGPEASAKkFKLLHPD--FISYLTDRFLKSKLlnthygHLYMPS 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164698489 295 TGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSLKYGYTSQASpHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23972  239 TGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKKKPLVFYAN-HDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 157-358 2.25e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 68.41  E-value: 2.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLvtmnpsviqrafedlvNATWREKLLQRLHGLNGS 236
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTL----------------RITYPEGAIQKPEQYEKD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 237 ILWIPAfmarGGK-ERVEWVNALILKHHVN--------VRTAYP----SLRLLHAvrgYWL-----------TNKVHIKR 292
Cdd:cd23981   69 SLFVLA----GFKwQDFKWLKYIVYKEKVSasdgfwksVATRVPrephEIRILNP---YFIqeaafsfiglpFNNGLMGR 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164698489 293 ---PTTGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23981  142 gniPTLGSVAITMALHNCDEVAVAG---FGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 131-366 4.41e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 69.01  E-value: 4.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 131 STMNVSQNLYELLPRTSPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVT------ 204
Cdd:cd23974   61 NLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTfstntl 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 205 MN------------PSVIQRAFEDLVNATWREKLLQRLHGLNGSILWIPAFMARGGKERVEWVNALILK--HHVNVRtaY 270
Cdd:cd23974  141 MNslrayagvgfngPPQSKETRYIFLPDHDRDYLLVKAALTHTPIDRGRDKSKRPSKYFGKDVTAEKFKiyHPDFIR--Y 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 271 PSLRLLHAvrGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSlKYGYTSQASPHTMPL 350
Cdd:cd23974  219 LRNRFLWS--PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDK-TYHKVVFYANHDLRL 291

                        250
                 ....*....|....*.
gi 164698489 351 EFKALKSLHEQGALKL 366
Cdd:cd23974  292 EMQLWQKLHKAGLIKL 307
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 153-358 7.44e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 67.07  E-value: 7.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 153 HFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLvTMN-----PSVIQRAFEDLVNATWREKLL 227
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTI-RMTypegaPKSEQEYDPTSLFVAVLFKSV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 228 QrLHGLNGSI------LWIPAFMARGGKERV-------EWVNALILKHHVNVRTAYPSLRllhavRGYWLTNKVHikrPT 294
Cdd:cd23983   80 D-FAWLKAMVkkeplsFWSRLFFWKEVADSIplkpsqfRILNPLIIKETALDILQYPEPQ-----SRLWGWDKNV---PT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164698489 295 TGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23983  151 LGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 147-334 4.77e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 65.63  E-value: 4.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 147 SPLKNKHFQTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLV-NATWREK 225
Cdd:cd23986   42 SKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIdSSLYKDV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 226 LLqrlhglngsILWIPAFMARGGKERVEWVNALILKHHVNVRTAYPS--LRLLHAvRGYW---------LTNKVHIKRPT 294
Cdd:cd23986  122 IL---------VAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNqpFYILHP-KFIWqlwdiiqenTQEKIQPNPPS 191

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 164698489 295 TGLLMYTLATRFCNQIYLYGFwpFPLDQNQNPVKYH--YYDS 334
Cdd:cd23986  192 SGFIGILIMMSMCREVHVYEY--IPSVRQTDLCHYHerYYDA 231
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 155-315 7.71e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 65.29  E-value: 7.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 155 QTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKtdlvTMNPSVIQRAFEDLvnatwrekllqrlhGLN 234
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK----TTHHFVYPESFREL--------------AQN 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 235 GSILWIPaFMARGgkerVEWVNALILKHHVN---------VRTAYPSLRLLHA-----VRGYWLTNkvHIKRPTTGLLMY 300
Cdd:cd23980  144 VSMILVP-FKTLD----LEWVISATTTGTIShtyvpvprkIKVKKEKILIYHPafikyVFDRWLQG--HGRYPSTGILSV 216

                        170
                 ....*....|....*
gi 164698489 301 TLATRFCNQIYLYGF 315
Cdd:cd23980  217 IFSLHVCDEVDLYGF 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 155-333 1.87e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 54.48  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 155 QTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDL-VTMNPSVIQ--RAFEDLVNATwREKLLqrlh 231
Cdd:cd23978    2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLrVVAHSSVYRvlRRPQEFLNRT-PETTL---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 232 glngsILW-IPAFMARGGKERVEWVNALILKHHVNVRTAYPSLR-------LLHAVRGY-------WLtnkvhikrpTTG 296
Cdd:cd23978   77 -----IFWgPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRrmrqfddLFRGETGRdrkkshsWL---------STG 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 164698489 297 LLMYTLATRFCNQIYLYGFWPFP-LDQNQNPVK--YHYYD 333
Cdd:cd23978  143 WFTMVIAVELCDNVHVYGMVPPNyCSKRPTPKKmpYHYYE 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 157-336 4.30e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 53.33  E-value: 4.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDL-VTMNPSViqrafedlvnatwreKLLQRLHGL-- 233
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLrVVSHTSV---------------PLLLRNQGYff 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164698489 234 -----NGSILWIPA-FMARGGKERVewVNALilkhhVNVRTAYPSLRLLHAVRGYWL---------TNKVHIKRPT---T 295
Cdd:cd23977   69 qqsrdTKYVIWGPErNMDRDGGGKT--YRAL-----LTLAKMYPHLQVYTLTEEKMAycdgvfqneTGKNRMKSGSflsT 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 164698489 296 GLLMYTLATRFCNQIYLYGFW--PFPLDQNQNPVKYHYYDSLK 336
Cdd:cd23977  142 GWFTMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYEKGR 184
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 157-202 2.36e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 48.01  E-value: 2.36e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 164698489 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDL 202
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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