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Conserved domains on  [gi|118026925|ref|NP_033230|]
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solute carrier family 2, facilitated glucose transporter member 4 isoform 1 [Mus musculus]

Protein Classification

SLC2A family MFS transporter( domain architecture ID 13024542)

SLC2A (solute carrier family 2, facilitated glucose transporter) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of hexoses such as glucose and fructose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-474 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 717.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGpggpDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQW 105
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYG----EPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17431   77 FGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:cd17431  157 ISQIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVE 345
Cdd:cd17431  237 QMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVE 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 346 RAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 425
Cdd:cd17431  317 RAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 118026925 426 SNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGR 474
Cdd:cd17431  397 SNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
 
Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-474 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 717.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGpggpDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQW 105
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYG----EPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17431   77 FGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:cd17431  157 ISQIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVE 345
Cdd:cd17431  237 QMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVE 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 346 RAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 425
Cdd:cd17431  317 RAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 118026925 426 SNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGR 474
Cdd:cd17431  397 SNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
Sugar_tr pfam00083
Sugar (and other) transporter;
27-483 1.92e-157

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 455.58  E-value: 1.92e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   27 AVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPggpdsipQGTLTTLWALSVAIFSVGGMISSFLIGIISQWL 106
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSS-------LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  107 GRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILV 186
Cdd:pfam00083  74 GRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  187 AQVLGLESMLGTA-TLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGpARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:pfam00083 154 AYIFGLGLNKTSNsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEE-AREVLAKLRGVPDVDRELDEIKDSLE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVE 345
Cdd:pfam00083 233 AGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVD 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  346 RAGRRTLHLLGLAGMCGCAILMT-VALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAG 424
Cdd:pfam00083 313 RFGRRPLLLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALAT 392
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  425 FSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAF 483
Cdd:pfam00083 393 AANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
21-479 8.77e-108

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 329.30  E-value: 8.77e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   21 TGTLVLAVFSAVLGSLQFGYNIGVINApqkvieqSYnaTWLGRQGPGGPDSIPqGTLTTLWALSVAIFSVGGMISSFLIG 100
Cdd:TIGR00879  23 YWKVALLSLIAAIGGLMFGYDTGVIGG-------AL--ALPAFEFKFTSANSD-SYSSSLWGLVVSIFLVGGFIGALFAG 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  101 IISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI 180
Cdd:TIGR00879  93 WLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAI 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  181 VIGILVAQVLG-LESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGpARKSLKRLTGWADVSDALAE 259
Cdd:TIGR00879 173 TFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEE-ARKSLARLRGTSGEDKELLD 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  260 LKDEKRKLERERPMSLLQLLGS-----RTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG--QPAYATIGAGVV 332
Cdd:TIGR00879 252 ELELIDIKRSIEKRSVQPSWGSlfsstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdHAFLVSIIVGAV 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  333 NTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMT--VALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAEL 410
Cdd:TIGR00879 332 NFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEI 411
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  411 FSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLF-AVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:TIGR00879 412 FPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFfGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
28-485 3.01e-47

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 170.64  E-value: 3.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  28 VFSAVLGSLQFGYNIGVINAPqkviEQSYNATWLGRQGpggpdsIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLG 107
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGT----VESLNTVFVAPQN------LSESAANSLLGFCVASALIGCIIGGALGGYCSNRFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 108 RKRAMLANNVLAVLGG----------ALMGLANAAASYEILILgRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQ 177
Cdd:PRK10077  84 RRDSLKIAAVLFFISAlgsawpefgfTSIGPDNTGYVPEFVIY-RIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 178 LAIVIGILVAQ-----VLGLESMLGTATL-WPLLLALTVLPALLQLILLPFCPESPRYLyIIRNLEGPARKSLKRLTGWA 251
Cdd:PRK10077 163 FAIIFGQLVVYfvnyfIARSGDASWLNTDgWRYMFASEAIPALLFLMLLYFVPETPRYL-MSRGKQEQAEGILRKIMGNT 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 252 DVSDALAELKD--EKRKLERERPMSLLQLLgsrthrqpLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG--QPAYATI 327
Cdd:PRK10077 242 LATQALQEIKHslDHGRKTGGKLLMFGVGV--------IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAStdIALLQTI 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 328 GAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMcgcAILMT-VALLLLERVPAMsyVSIVAIFGFVAFFEIGPGPIPWFI 406
Cdd:PRK10077 314 IVGVINLTFTVLAIMTVDKFGRKPLQIIGALGM---AIGMFsLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVL 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 407 VAELFSQGPRPAAMAVAGFSNWTCNFIVGMGF-------QYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:PRK10077 389 LSEIFPNAIRGKALAIAVAAQWIANYFVSWTFpmmdknsWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEM 468

                 ....*.
gi 118026925 480 SAAFRR 485
Cdd:PRK10077 469 EALWEP 474
AraJ COG2814
Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];
82-202 2.66e-07

Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 225371 [Multi-domain]  Cd Length: 394  Bit Score: 52.62  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:COG2814   51 GQLITAYALGVALGAPLLALLTGRLERRRLLLGLLALFIVSNLLSALAP---SFAVLLLARALAGLAHGVFWSIAAALAA 127
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 118026925 162 EIAPTHLRG-ALGTlnqlaIVIGILVAQVLG--LESMLGTATLW 202
Cdd:COG2814  128 RLVPPGKRGrALAL-----VFTGLTLATVLGvpLGTFLGQLFGW 166
 
Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-474 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 717.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGpggpDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQW 105
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYG----EPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17431   77 FGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:cd17431  157 ISQIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVE 345
Cdd:cd17431  237 QMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVE 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 346 RAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 425
Cdd:cd17431  317 RAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 118026925 426 SNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGR 474
Cdd:cd17431  397 SNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
27-474 3.13e-163

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 469.82  E-value: 3.13e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  27 AVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSipqgTLTTLWALSVAIFSVGGMISSFLIGIISQWL 106
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDS----ELDLLWSLIVSIFFIGGAIGSFISAFLANRF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 107 GRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILV 186
Cdd:cd17357   77 GRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 187 AQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGW-ADVSDALAELKDEKR 265
Cdd:cd17357  157 GQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGIeDDVDQELEEIKKESE 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGV--GQPAYATIGAGVVNTVFTLVSVLL 343
Cdd:cd17357  237 QMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFspQLAEWANLGIGIVNVLSTIVGPFL 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 344 VERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVA 423
Cdd:cd17357  317 IEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLG 396
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118026925 424 GFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGR 474
Cdd:cd17357  397 SSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
Sugar_tr pfam00083
Sugar (and other) transporter;
27-483 1.92e-157

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 455.58  E-value: 1.92e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   27 AVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPggpdsipQGTLTTLWALSVAIFSVGGMISSFLIGIISQWL 106
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSS-------LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  107 GRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILV 186
Cdd:pfam00083  74 GRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  187 AQVLGLESMLGTA-TLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGpARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:pfam00083 154 AYIFGLGLNKTSNsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEE-AREVLAKLRGVPDVDRELDEIKDSLE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVE 345
Cdd:pfam00083 233 AGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVD 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  346 RAGRRTLHLLGLAGMCGCAILMT-VALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAG 424
Cdd:pfam00083 313 RFGRRPLLLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALAT 392
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  425 FSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAF 483
Cdd:pfam00083 393 AANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
27-479 1.39e-151

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 440.51  E-value: 1.39e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  27 AVFSAVLG-SLQFGYNIGVINAPQKVIEQSYNATWLGRQGpggpDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQW 105
Cdd:cd17432    1 ATLAAAFGsSFQYGYNLSVVNSPTPYIQNFYNETWTERYG----TPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17432   77 LGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKR 265
Cdd:cd17432  157 LGQVLGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 KLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGV--GQPAYATIGAGVVNTVFTLVSVLL 343
Cdd:cd17432  237 AEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIpeDKIQYVTVGTGACEVLATITCVLV 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 344 VERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVA 423
Cdd:cd17432  317 IERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVA 396
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 118026925 424 GFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:cd17432  397 GSLNWLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
21-479 8.77e-108

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 329.30  E-value: 8.77e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   21 TGTLVLAVFSAVLGSLQFGYNIGVINApqkvieqSYnaTWLGRQGPGGPDSIPqGTLTTLWALSVAIFSVGGMISSFLIG 100
Cdd:TIGR00879  23 YWKVALLSLIAAIGGLMFGYDTGVIGG-------AL--ALPAFEFKFTSANSD-SYSSSLWGLVVSIFLVGGFIGALFAG 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  101 IISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI 180
Cdd:TIGR00879  93 WLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAI 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  181 VIGILVAQVLG-LESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGpARKSLKRLTGWADVSDALAE 259
Cdd:TIGR00879 173 TFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEE-ARKSLARLRGTSGEDKELLD 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  260 LKDEKRKLERERPMSLLQLLGS-----RTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG--QPAYATIGAGVV 332
Cdd:TIGR00879 252 ELELIDIKRSIEKRSVQPSWGSlfsstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdHAFLVSIIVGAV 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  333 NTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMT--VALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAEL 410
Cdd:TIGR00879 332 NFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEI 411
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  411 FSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLF-AVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:TIGR00879 412 FPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFfGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
31-470 4.40e-101

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 308.35  E-value: 4.40e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  31 AVLGSLQFGYNIGVINAPQKVIEQSYNAtwlgrqgpggpdsipqGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKR 110
Cdd:cd17315    2 AALGGLLFGYDLGVINGALLYIAKDLGF----------------GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRK 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 111 AMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVL 190
Cdd:cd17315   66 SLLIAAVLYVIGALLSALAP---NVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLL 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 191 GLESMLGTATLWPLLLALTVLPALLQLILLPFCPESprylyiirnlegparkslkrltgwadvsdalaelkdekrklere 270
Cdd:cd17315  143 GLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES-------------------------------------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 271 rpmsllqllgsrthrQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG-QPAYATIGAGVVNTVFTLVSVLLVERAGR 349
Cdd:cd17315  179 ---------------RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGtASILASIIVGVVNLLATLVAIRLVDKVGR 243
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 350 RTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 429
Cdd:cd17315  244 RPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWI 323
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 118026925 430 CNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPE 470
Cdd:cd17315  324 FNFIVGLTFLIMVSTIGlAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
25-478 5.91e-87

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 274.07  E-value: 5.91e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  25 VLAVFSAVLGSLQFGYNIGvinapqkvieqsYNATWLgrqgpggpDSIPQGTLTTLWaLSVAIFS-------VGGMISSF 97
Cdd:cd17358    1 LLATFVANLGSFSFGIAVG------------WSSPAL--------PSLMSDNSLSLP-LTVAQFSwfgslltLGALIGAL 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  98 LIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQ 177
Cdd:cd17358   60 LSGKLADRIGRKRTLLISAIPCILGWLLIAFAK---DVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQ 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 178 LAIVIGILVAQVLGleSMLGTATLWPLLLALTVlpalLQLILLPFCPESPRYLyIIRNLEGPARKSLKRLTGW-ADVSDA 256
Cdd:cd17358  137 LLVNIGILLGYVLG--SFLPWRTLALIGAIPPV----VFLILLFFIPESPRWL-AKKGREEEAEKSLQFLRGKdADISKE 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 257 LAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG-QPAYATIGAGVVNTV 335
Cdd:cd17358  210 AAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGlDPNTATIIIGVVQVV 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 336 FTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFG---FVAFFEIGPGPIPWFIVAELFS 412
Cdd:cd17358  290 GTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEHGALLSSVSWLPLVGlviYIISFSIGLGPLPWVIMSEIFP 369
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118026925 413 QGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLF-AVLLLGFFIFTFLKVPETRGRTFDQ 478
Cdd:cd17358  370 AKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIfAGICGLALVFVLLFVPETKGKSLEE 436
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
26-447 6.11e-65

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 215.12  E-value: 6.11e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATwlgrqgpggpdsipqgTLTTLWALSVAIfsVGGMISSFLIGIISQW 105
Cdd:cd17359    1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLT----------------PFLEGLVVSSAL--LGAAIGALFAGRLADR 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLANAAAsyeILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17359   63 FGRRKTLLISAVLFFISALGSAFSPNFT---IFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVL------GLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYiirnlegparkslkrltgwadvsdalae 259
Cdd:cd17359  140 LAYIVnylianAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLV---------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 260 lkdekrklererpmsllqllgsRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPA--YATIGAGVVNTVFT 337
Cdd:cd17359  192 ----------------------SKGKPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAalLQTIGIGVVNVIFT 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 338 LVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRP 417
Cdd:cd17359  250 IIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRG 329
                        410       420       430
                 ....*....|....*....|....*....|
gi 118026925 418 AAMAVAGFSNWTCNFIVGMGFQYVADAMGP 447
Cdd:cd17359  330 LAMGIAVFFLWIANFLVSLTFPILLAAFGL 359
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
25-483 3.07e-56

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 192.85  E-value: 3.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  25 VLAVFSAVLGSLqFGYNIGVINApqKVIEQSYNATWLGRQGPGGPDSIPQGtlttlwaLSVAIFSVGGMISSFLIGIISQ 104
Cdd:cd17356    1 LLCAFVSLGGFL-FGYDTGSISG--ILNMKSFQKYFADNTGTYYPSSSRQG-------LIVSIVNLGSFFGALISSFLSD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 105 WLGRKRAMLANNVLAVLGGALMGLANAaaSYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGI 184
Cdd:cd17356   71 RIGRKKSIQIGCVIYIIGAIIQVAAIG--KWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 185 LVAQVL--GLESMLGTAT---------LWPLLLALTVLpallqlillpFCPESPRYLYiirnlegparkslkrltgwadv 253
Cdd:cd17356  149 LVAYCInyGTHKLDGSAQwriplglqiVWGLLLLIGMF----------FLPESPRWLY---------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 254 sdalaelkdekrklererpmsllqllgsrthrqPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQ--PAYATIGAGV 331
Cdd:cd17356  197 ---------------------------------RTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGssPLLTSIILYI 243
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 332 VNTVFTLVSVLLVERAGRRTLHLLGLAGMCGC--------AILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIP 403
Cdd:cd17356  244 VNFVSTIPGLFFVDKFGRRTCLLIGAAGMSIClfiyaavgVRYLIPNPQSGTSNKSAGNGMIVFICLFIFSFATTWGPIA 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 404 WFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAF 483
Cdd:cd17356  324 WVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
30-448 3.43e-55

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 189.02  E-value: 3.43e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  30 SAVLGSLQFGYNIGVINAPQKVIeqsynatwlgrqgpggPDSIPQGTLTTLW-ALSVAIFSVGGMISSFLIGIISQWLGR 108
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYI----------------KDDLGEVVLSTGWqELIVSSTVAGAAVGAAIGGWLNDRFGR 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 109 KRAMLANNVLAVLGGALMGlanAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQ 188
Cdd:cd17360   65 RPCILLADALFTIGAIVMA---AAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAY 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 189 VLGLeSMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYlyiirnlegparkslkrltgwadvsdalaelkdekrkle 268
Cdd:cd17360  142 VING-AFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRW--------------------------------------- 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 269 rerpmsllqllgsRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVV---NTVFTLVSVLLVE 345
Cdd:cd17360  182 -------------PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVagtNFIFTIVGMYLID 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 346 RAGRRTLHLLGLAGMCGCAILMTVallllervpamsYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 425
Cdd:cd17360  249 KFGRRKLLLISLFGVIVALVVLAV------------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAA 316
                        410       420
                 ....*....|....*....|...
gi 118026925 426 SNWTCNFIVGMGFQYVADAMGPY 448
Cdd:cd17360  317 VNWVFNLLVSQTFLTLTQAIGPY 339
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
31-479 8.34e-55

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 188.72  E-value: 8.34e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  31 AVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRqgpgGPDSIPQGTLttlwalsVAIFSVGGMISSFLIGIISQWLGRKR 110
Cdd:cd17362    2 PALGGLLFGYDIGATSGALLSITSPALSGTDWY----NLSSLQSGLV-------VSGSLLGALLGSLVAGALIDRLGRRK 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 111 AMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVL 190
Cdd:cd17362   71 ELILAALLYLVGSLVTGLAP---SYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVS 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 191 ---------GLESMLGTATLWPLLLALTVLpallqlillpFCPESPRYlyiirnlEGPARKslkrltgwadvsdalaelk 261
Cdd:cd17362  148 gyafadvvgGWRYMYGLAAPPALLLGIGMW----------FLPPSPRW-------QGNYRK------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 262 dekrklererpmsllqllgsrthrqPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGV---GQPAYATIGAGVVNTVFTL 338
Cdd:cd17362  192 -------------------------PLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsaaSDATLVSVGLGVFKLLMTI 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 339 VSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPA-MSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRP 417
Cdd:cd17362  247 VAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQMGPAgLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRG 326
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118026925 418 AAMAVAGFSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:cd17362  327 RAIALAVLVNFGSNALVSLAFLPLQELIGlPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
26-478 5.87e-48

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 171.21  E-value: 5.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVIN---------APQKVIEQSYNATWLGrqgpggpdsipqgtlttlwalsvAIFSVGGMISS 96
Cdd:cd17433    2 LATFAAVLGPLSFGFVLGYSSpaipslqriADPALRLDDAAASWFG-----------------------SVVTLGAAAGG 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  97 FLIGIISQWLGRKRAMLANNVLAVLGGALMglaNAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLN 176
Cdd:cd17433   59 VLGGWIVDRAGRKLSLMLCSVPFIAGFTVI---TAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCV 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 177 QLAIVIGILVAQVLGLesmlgtATLWPLLLALTVLPALLQLILLPFCPESPRYLyIIRNLEGPARKSLKRLTGW-ADVSD 255
Cdd:cd17433  136 QLMVVIGIMGAYLAGL------VLDWRWLAVLGSIPPTLMLLLMCFMPETPRFL-LTQHRRQEAMAALRFLRGPdQGWEW 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 256 ALAELKDEKRKLERERPMSLLQLLGSRthrQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTV 335
Cdd:cd17433  209 ECIGIEQSFHLEEQSFSLALLKQPGIY---KPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSVASVIVAAIQVL 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 336 FTLVSVLLVERAGRRTlhLLGLAGmcgcaILMTVAllllerVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP 415
Cdd:cd17433  286 FTAVAALIMDRAGRKV--LLVLSG-----VVMVFS------TAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHV 352
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118026925 416 RPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFL-LFAVLLLGFFIFTFLKVPETRGRTFDQ 478
Cdd:cd17433  353 RGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYGTFwLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
xylE PRK10077
D-xylose transporter XylE; Provisional
28-485 3.01e-47

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 170.64  E-value: 3.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  28 VFSAVLGSLQFGYNIGVINAPqkviEQSYNATWLGRQGpggpdsIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLG 107
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGT----VESLNTVFVAPQN------LSESAANSLLGFCVASALIGCIIGGALGGYCSNRFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 108 RKRAMLANNVLAVLGG----------ALMGLANAAASYEILILgRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQ 177
Cdd:PRK10077  84 RRDSLKIAAVLFFISAlgsawpefgfTSIGPDNTGYVPEFVIY-RIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 178 LAIVIGILVAQ-----VLGLESMLGTATL-WPLLLALTVLPALLQLILLPFCPESPRYLyIIRNLEGPARKSLKRLTGWA 251
Cdd:PRK10077 163 FAIIFGQLVVYfvnyfIARSGDASWLNTDgWRYMFASEAIPALLFLMLLYFVPETPRYL-MSRGKQEQAEGILRKIMGNT 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 252 DVSDALAELKD--EKRKLERERPMSLLQLLgsrthrqpLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG--QPAYATI 327
Cdd:PRK10077 242 LATQALQEIKHslDHGRKTGGKLLMFGVGV--------IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAStdIALLQTI 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 328 GAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMcgcAILMT-VALLLLERVPAMsyVSIVAIFGFVAFFEIGPGPIPWFI 406
Cdd:PRK10077 314 IVGVINLTFTVLAIMTVDKFGRKPLQIIGALGM---AIGMFsLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVL 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 407 VAELFSQGPRPAAMAVAGFSNWTCNFIVGMGF-------QYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:PRK10077 389 LSEIFPNAIRGKALAIAVAAQWIANYFVSWTFpmmdknsWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEM 468

                 ....*.
gi 118026925 480 SAAFRR 485
Cdd:PRK10077 469 EALWEP 474
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
31-479 9.22e-44

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 159.10  E-value: 9.22e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  31 AVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQgpggpdsipqgtlttlwaLSVAIFSVGGMISSFLIGIISQWLGRKR 110
Cdd:cd17437    2 ASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEE------------------VLIGSLNIISLVGSLAAGRTSDWIGRRY 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 111 AMLANNVLAVLGGALMGLAnaaASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQV- 189
Cdd:cd17437   64 TIALAALIFFVGALLMGVA---PNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVs 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 190 ----------LGLESMLGTATLWPLLLALTVLpallqlillpFCPESPRYlyiirnlegparkslkrltgwadvsdalae 259
Cdd:cd17437  141 nyafsglplhVGWRLMLGVGAVPSLFLAIGVL----------AMPESPRW------------------------------ 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 260 lkdekrklererpmsllqllgSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPA---YATIGAGVVNTVF 336
Cdd:cd17437  181 ---------------------TPAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDkllLATVAVGVTKTLF 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 337 TLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLER----VPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFS 412
Cdd:cd17437  240 ILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDRngggLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFP 319
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118026925 413 QGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:cd17437  320 LRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITtGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
83-438 1.15e-41

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 153.17  E-value: 1.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASyeiLILGRFLIGAYSGLTSGLVPMYVGE 162
Cdd:cd17361   55 LFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAM---LIVGRILLGFGVGFGNQAVPLYLSE 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 163 IAPTHLRGALGTLNQLAIVIGILVAQVLGLesmlGTATL----WPLLLALTVLPALLQLILLPFCPESPrylyiirnleg 238
Cdd:cd17361  132 MAPAKLRGALNIGFQLAITIGILIANLINY----GTSKIkpngWRLSLGLAAVPALILLLGSLFLPETP----------- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 239 parkslkrltgwadvsdalaelkdekrklererpmsllqllgsrtHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAG 318
Cdd:cd17361  197 ---------------------------------------------NSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLG 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 319 VGQPA--YATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVP-----AMSYVSIVAIFGF 391
Cdd:cd17361  232 FGSDAslISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGILLAVKFGDGgelpkAYAIAVVVLICLY 311
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 118026925 392 VAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGF 438
Cdd:cd17361  312 VAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAF 358
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
26-478 8.10e-38

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 143.43  E-value: 8.10e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQS---------YNATWLGrqgpggpdsipqgtlttlwalsvAIFSVGGMISS 96
Cdd:cd17434    2 LAVFSAVLGNFSFGYALVYTSPVIPALEQGddprlhlnvHQISWFG-----------------------SVFTLGAAAGG 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  97 FLIGIISQWLGRKRAMLANNVLAVLGGALMGlanAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLN 176
Cdd:cd17434   59 LSAMFLNDRLGRKLSIMFSAVPSALGYLLMG---SAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACP 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 177 QLAIVIGILVAQVLGLesmlgtATLWPLLLALTVLPALLQLILLPFCPESPRYLyIIRNLEGPARKSLKRLTGwaDVSDA 256
Cdd:cd17434  136 QIMAVFGSLALYALGL------LLPWRWLAVAGEVPVVIMILLLCFMPNSPRFL-ISKGKDEKALKALAWLRG--PNTDY 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 257 LAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG-QPAYATIGAGVVNTV 335
Cdd:cd17434  207 MTEFEQIKDNIRKQSSRLSWAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVIlEPKYDAALVGAVRLL 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 336 FTLVSVLLVERAGRRTLhllglagmcgcaiLMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP 415
Cdd:cd17434  287 SVAIAASLMDKAGRKIL-------------LFTSAFLMFAANLSMGLIPLIAAMLFIMGYAMGWGPITWLLMSEILPLKA 353
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118026925 416 RPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFI-FTFLKVPETRGRTFDQ 478
Cdd:cd17434  354 RGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIiFTACCVPETKGRTLEQ 417
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
85-479 1.24e-33

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 131.07  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  85 VAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnaaASYEILILGRFLIGAYSGLTSGLVPMYVGEIA 164
Cdd:cd17435   42 VSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCS---VSYTVLIVGRIAIGVSISLSSIATCVYIAEIA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 165 PTHLRGALGTLNQLAIVIGILVAQVLGLeSMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLegparksl 244
Cdd:cd17435  119 PQHRRGLLVSLNELMIVIGILLAYISNY-AFANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNM-------- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 245 krltgwadvsdalaelkdekrklererpmsllqllgsrthRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAY 324
Cdd:cd17435  190 ----------------------------------------RARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 325 ATI---GAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCgcAILMTVALlllervpamsYVSIVAIFGFVAFFEIGPGP 401
Cdd:cd17435  230 ASLastGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMA--VSLVTMGL----------WLSLASLLVYVAAFSIGLGP 297
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118026925 402 IPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:cd17435  298 MPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGlPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
26-479 6.87e-25

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 106.04  E-value: 6.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATwlgrqgpggpdSIPQGTLttlwalsVAIFSVGGMISSFLIGIISQW 105
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLS-----------CFEQEAL-------VSALLIGALLASLIGGFLIDR 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 106 LGRKRAMLANNVLAVLGGALMGLAnaaASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGIL 185
Cdd:cd17436   63 HGRRTSILGSNLVLLAGSLILTLA---GSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGIL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 186 VAQVLGLeSMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGparkslkrltgwadvsdalaelkdekr 265
Cdd:cd17436  140 ISYALNY-FFSNVLTGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIKDNMRR--------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 266 klererpmsllqllgsRThrqplIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPA---YATIGAGVVNTVFTLVSVL 342
Cdd:cd17436  192 ----------------RT-----LVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSsavLASVGLGVVKVIATLLAML 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 343 LVERAGRRTLHLLGlagmcgcAILMTVALLLLErvpamSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAV 422
Cdd:cd17436  251 FADRAGRRSLLIAG-------CSVMAVSVSGIG-----LWITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSF 318
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 118026925 423 AGFSNWTCNFIVGMGFQYVADAMG-PYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
Cdd:cd17436  319 CNSFNWAANLLITLSFLDLIDVIGlSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
75-448 1.36e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 105.20  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  75 GTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnaaASYEILILGRFLIGAYSGLTSG 154
Cdd:cd06174   27 GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA---PSFWLLLLGRFLLGLGSGLIDP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 155 LVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRylyiir 234
Cdd:cd06174  104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP------ 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 235 nlegparkslkrltgwadvsdalaelKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIF 314
Cdd:cd06174  178 --------------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 315 ESAGVG--QPAYATIGAGVVNTVFTLVSVLLVER-AGRRTLHLLGLAGMcgcAILMTVALLllervpAMSYVSIVAIFGF 391
Cdd:cd06174  232 DLGGLSvaVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLM---ALGLALLLL------APSLLLLLLLLLL 302
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 118026925 392 VAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPY 448
Cdd:cd06174  303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
82-387 2.48e-10

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 62.73  E-value: 2.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLannvLAVLGGALMGLANAAA-SYEILILGRFLIG-AYSGLTSGLVPMY 159
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLL----LSTLVTAVSGVLTAFSpNYTVFLVFRLLVGmGIGGIWVQAVVLN 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  160 VgEIAPTHLRGALGTLNQLAIVIGILvaqvlgLESMLGTATL-WPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEg 238
Cdd:TIGR00898 206 T-EFLPKKQRAIVGTLIQVFFSLGLV------LLPLVAYFIPdWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIE- 277
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  239 PARKSLKRL--TGWADVSDALAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSqqlsgiNAVFYYSTSIFES 316
Cdd:TIGR00898 278 EALKILQRIakINGKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFT------TAFSYYGLVLDLG 351
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118026925  317 aGVGQPAYAT-IGAGVVNTVFTLVSVLLVERAGRRTlhllglaGMCGCAILMTVALLLLERVPAMSYVSIVA 387
Cdd:TIGR00898 352 -NLGGNIYLDlFISGLVELPAKLITLLLIDRLGRRY-------TMAASLLLAGVALLLLLFVPVDLYFLRTA 415
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
79-426 2.46e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 2.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  79 TLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPM 158
Cdd:cd17325   31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT---SYWQLLLARFLQGLASAAVWPAAMA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 159 YVGEIAPTHLRG-ALGTLNQ-------LAIVIGILVAQVLGLESMLGTATLWPLLLALTVlpallqlillpfcpespryL 230
Cdd:cd17325  108 LIADIAPPEERGrAMGIFSSaiglgflIGPLLGGLLADALGYRAPFLVCAALALLALVLA-------------------L 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 231 YIIRNLEGPARKslkrltgwadvsdalaelkdekrklERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQL--SGINAVF- 307
Cdd:cd17325  169 LLLPEPRPPPNK-------------------------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFafGALEPFLp 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 308 YYSTSIFEsAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLagmcgcaILMTVALLLLERVPAMSYVSIVA 387
Cdd:cd17325  224 LYAAELGG-LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL-------LLSAVALLLLPLATSFWLLLLLL 295
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 118026925 388 IFGFVAFFEIGPGPIPwfIVAELFSQGPRPAAMAVAGFS 426
Cdd:cd17325  296 ALLGLGLGLVFPATLA--LLADIVPPEGRGTAMGLFNTA 332
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
76-209 1.10e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 53.76  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  76 TLTTLWALSVAIFsvGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGL 155
Cdd:cd17316   35 LLQTGLLFAAGFL--GRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP---TPILLLVLRFLQGIGIGGEYPG 109
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 118026925 156 VPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLG--LESMLGTATLWPLLLALT 209
Cdd:cd17316  110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAslLIPLLSGDWGWRILFLIG 165
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
83-210 1.15e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 53.76  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGrFLIGAYSGLTSGLVPMYVGE 162
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL-FILSFFVGGVWGALYAYLAE 295
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118026925 163 IAPTHLRG-ALGTLNQLAIVIGILVAQVLG--LESMLGTATLWPLLLALTV 210
Cdd:cd17316  296 LFPTEVRAtGVGLSYNLGRLGGGGAPPLIAllLASTGGTGVPALILALLAI 346
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
82-208 1.55e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP---SFALLLLARALAGLAHGGFWAIAAAYAA 113
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 118026925 162 EIAPTHLRG----------ALGTLnqLAIVIGILVAQVLGLESMLGTATLWPLLLAL 208
Cdd:cd17324  114 DLVPPEKRGraiglvfsglTLGLV--LGRPLGGLLGQLLGWRAAFLAIAVLALLAAL 168
AraJ COG2814
Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];
82-202 2.66e-07

Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 225371 [Multi-domain]  Cd Length: 394  Bit Score: 52.62  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:COG2814   51 GQLITAYALGVALGAPLLALLTGRLERRRLLLGLLALFIVSNLLSALAP---SFAVLLLARALAGLAHGVFWSIAAALAA 127
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 118026925 162 EIAPTHLRG-ALGTlnqlaIVIGILVAQVLG--LESMLGTATLW 202
Cdd:COG2814  128 RLVPPGKRGrALAL-----VFTGLTLATVLGvpLGTFLGQLFGW 166
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
82-191 3.09e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.57  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD---SFALLLAGRALQGIGAAGLGPLALTLIG 113
                         90       100       110
                 ....*....|....*....|....*....|
gi 118026925 162 EIAPTHLRGALGTLNQLAIVIGILVAQVLG 191
Cdd:cd17474  114 DLFEGGERAKAMGLYEAALGLGIAVGPLLG 143
MFS_1 pfam07690
Major Facilitator Superfamily;
83-427 9.25e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 9.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLanaAASYEILILGRFLIGAYSGLTSGLVPMYVGE 162
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF---ASSLWLLLVLRVLQGLGAGALFPAALALIAD 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  163 IAPTHLRGALGTLNQLAIVIGILVAQVLGleSMLGTATLWPLLLALTVLPALLQLillpfcpespryLYIIRNLEGPARK 242
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLG--GLLASLFGWRAAFLILAILSLLAA------------VLLLLPRPPPESK 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  243 slkrltgwadvsdalaelkdEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSqqlSGINAVFYYSTSIFESAGVGQP 322
Cdd:pfam07690 179 --------------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG---FAFFGLLTYLPLYQEVLGLSAL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  323 AYATIGA--GVVNTVFTLVSVLLVERAGRRTLhllgLAGMCGCAILMTVALLLLerVPAMSYVSIVAIFGFVAFFEIGPG 400
Cdd:pfam07690 236 LAGLLLGlgGLLGAIGRLLLGRLSDRLGRRRR----LLLALLLLILAALGLLLL--SLTLSSLWLLLALLLLGFGFGLVF 309
                         330       340
                  ....*....|....*....|....*..
gi 118026925  401 PIPWFIVAELFSQGPRPAAMAVAGFSN 427
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAG 336
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
82-186 1.88e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.89  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLanaAASYEILILGRFLIG-AYSGL-TSGLVpmY 159
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAF---SPSYELFLVLRFLVGvTSAGIfTVGFV--L 102
                         90       100
                 ....*....|....*....|....*..
gi 118026925 160 VGEIAPTHLRGALGTLNQLAIVIGILV 186
Cdd:cd17317  103 GMEIVGPKYRSFVGILFGLFWALGYML 129
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
83-412 3.97e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.06  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGM---ISSFLIGIISQWLGRKRAMLANnvLAVLGGA--LMGLANAAASYEI-----LILGRFLIG-AYSGL 151
Cdd:cd17369   45 AAFATFGVGFLarpLGGVVFGHFGDRIGRKKTLVLT--LLLMGIAtfLIGLLPTYAQIGIlapilLVLLRLLQGlALGGE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 152 TSGLVPMYVgEIAPTHLRGALGTLNQLAIVIGILVAQV--LGLESMLGTATL----W--PLLLALTVLPALlqlillpfc 223
Cdd:cd17369  123 WGGAVLMAV-EHAPPKRRGFYGSFPQLGAPVGLLLATGvfLLLSALLSDEAFlswgWriPFLLSAVLVAVG--------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 224 pespryLYIIRNLEGparkslkrltgwadvSDALAELKDEKRKlereRPMSLLQLLgsRTHRQPLIIAVVLQLSQQ-LSG 302
Cdd:cd17369  193 ------LYIRLRLEE---------------TPVFRRAKEAGQV----VRAPLVEVL--RRHWRALLLAIGLRLAENvLFY 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 303 INAVF--YYSTSIfesAGVGQPAYATIG--AGVVNTVFTLVSVLLVERAGRRTLHllgLAGMCGCAILMTVALLLLERVP 378
Cdd:cd17369  246 LFTTFalSYATQT---LGVDRSTVLLAVliASVVAAITIPLFGWLSDRVGRRPVY---LAGALLAALFAFPFFWLLDTGS 319
                        330       340       350
                 ....*....|....*....|....*....|....
gi 118026925 379 AMSYVsIVAIFGFVAFFEIGPGPIPWFIvAELFS 412
Cdd:cd17369  320 TWLIV-LAAVVVLGVLHGMMYGPQAAFL-AELFP 351
MFS_1 pfam07690
Major Facilitator Superfamily;
78-187 4.21e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   78 TTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVP 157
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
                          90       100       110
                  ....*....|....*....|....*....|
gi 118026925  158 MYVGEIAPTHLRGALGTLNQLAIVIGILVA 187
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
73-423 1.06e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 47.75  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  73 PQGTLTTLWALSVAIFSVGGM---ISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnaaASYE--------ILILG 141
Cdd:cd17368   31 PSGSEFASLLLTFATFGVGFFmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALA---PTYAtigiaaplLVLLA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 142 RFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLN----QLAIVIGILVAQVLGLesMLGTATL----W--PLLLALTVL 211
Cdd:cd17368  108 RLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQsasqQVAIVAGALVGYLLSL--TLTAEALaewgWriPFFIGLLII 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 212 pallqlillpfcpesPRYLYIIRNLEGParkslkrltgwadvsdaLAELKdEKRKLERERPMSLLqllgsRTHRQPLIIA 291
Cdd:cd17368  186 ---------------PLGLWLRRSLEET-----------------EAFLE-RKARPTRRELFALL-----ANNRRIILLG 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 292 VVLQLSQQLSGINAVFYYSTSIFESAGVGQPA--YATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLagmcgCAILMTV 369
Cdd:cd17368  228 MLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDsfLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVIT-----LAALVTL 302
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 118026925 370 ALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVA 423
Cdd:cd17368  303 YPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLV 356
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
83-192 1.95e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAAsyeILILGRFLIGA-YSGLTSGLVPMYVG 161
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA---LLLVLRLIHGIgWGAFTTAAATLVAD 111
                         90       100       110
                 ....*....|....*....|....*....|.
gi 118026925 162 EIAPTHLRGALGtLNQLAIVIGILVAQVLGL 192
Cdd:cd17489  112 IIPPSRRGEGIG-YYGLATTLAMALGPALGL 141
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
84-425 4.84e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 45.75  E-value: 4.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  84 SVAIFSVGGM---ISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnaaASYE--------ILILGRFLIGAYSGLT 152
Cdd:cd17367   42 TAAVFAVGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVT---PTYAtigiwapiILLLARLLQGLSVGGE 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 153 SGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQV--LGLESMLGTATL----WPL------LLALTVlpallqlill 220
Cdd:cd17367  119 YGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGvlLVLQHTLGEDQMaawgWRIpfllggVLAVVV---------- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 221 pfcpespryLYIIRNLEgparkslkrltgwadvsdalAELKDEKRKLERERPMSLLQLLgsRTHRQPLIIAVVLQLSQQL 300
Cdd:cd17367  189 ---------LWLRRGLE--------------------ETESFEAIAESNEASAGTLREL--RRHPRELLLVVGLTAGGTL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 301 SGINAVFYYSTSIFESAGV--GQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHL-LGLAGMcgcaILMTVALLLLERV 377
Cdd:cd17367  238 AFYTWTTYLQKFLVNTAGFskGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLfFGIGGT----LATVPLLSALDHT 313
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 118026925 378 PAMSYVSIVAIFGFVafFEIGPGPIPWFIVAELFSQGPR------PAAMAVAGF 425
Cdd:cd17367  314 DSPYTAFALVLVGLV--FLSGYTSINAVVKAELFPTHVRalgvglPYALAVAIF 365
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
82-210 5.83e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.24  E-value: 5.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAysglTSGLVPMYVG 161
Cdd:cd17478  233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFA----SFPVTVVLAQ 308
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 118026925 162 EIAPTHLRGALGTLNQLAIVIGIL-------VAQVLGLESMLGTATLWPLLLALTV 210
Cdd:cd17478  309 ELLPGNVGLASGLMMGLSFGLGGIgapvlgaLADAFGLESVLLILALLPLLGALLA 364
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
80-190 7.06e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  80 LWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGlTSGLVPMY 159
Cdd:cd17330   35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR---NLWLLFLARFLDGLTGG-NVSVAQAY 110
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 118026925 160 VGEIAPTHLR----GALGTLNQLAIVIGILVAQVL 190
Cdd:cd17330  111 IADITDEEERakafGIISAAFGLGFILGPALGGFL 145
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
67-423 8.02e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.99  E-value: 8.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  67 GGPDSIPQGTLTTLWALSVAIFSVGGmissfliGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIG 146
Cdd:cd17371   29 FGLDEAEAGLLGTVTLAGGAIGGILG-------GILADRFGRVRVLVITILLFAVFTLLCGFAQ---NYWQLLILRALAG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 147 AYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLG--LESMLGTATLWPLLLALTVLPALLQLILLPFCP 224
Cdd:cd17371   99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAalLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVK 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 225 ESPRYLyiirnlegparkslkrltgwadvsdalaelkDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLqlsqqLSGIN 304
Cdd:cd17371  179 EPPQWQ-------------------------------AARAARRHFADRPSLRELFSPPLLRTTLLASLL-----ATGAL 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 305 AVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVL-------LVERAGRRTLHLLGlaGMCGCAILMTVALLLLerv 377
Cdd:cd17371  223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLgylaggfLADRIGRRNNFALF--ALGSAISILLYFFLPL--- 297
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 118026925 378 pamSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVA 423
Cdd:cd17371  298 ---SPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFC 340
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
78-191 1.00e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  78 TTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVP 157
Cdd:cd17325  234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATL 310
                         90       100       110
                 ....*....|....*....|....*....|....
gi 118026925 158 MYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLG 191
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
81-230 2.43e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.50  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925   81 WALSVAIFsvGGMISSFLIGIISQWLGRKRAMLannVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYV 160
Cdd:TIGR00895  56 FLFSAGLI--GMAFGALFFGPLADRIGRRRVLL---WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALV 130
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118026925  161 GEIAPTHLRGALGTLNQLAIVIGILVA--------QVLGLESMLGTATLWPLLLALTVLPallqlillpFCPESPRYL 230
Cdd:TIGR00895 131 SEYAPKRFRGTAVGLMFCGYPIGAAVGgflagwliPVFGWRSLFYVGGIAPLLLLLLLMR---------FLPESIDFL 199
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
77-184 2.76e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  77 LTTLWA-LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGL 155
Cdd:cd17321  201 YSPLQAgLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATP 280
                         90       100       110
                 ....*....|....*....|....*....|...
gi 118026925 156 VPMYVGEIAPTHLRGA----LGTLNQLAIVIGI 184
Cdd:cd17321  281 LTNAALSSVPKEKAGAasgiLNTARQLGGALGV 313
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
85-192 5.76e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 42.20  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  85 VAIFSVGGMISSFLIGIISQWLG-RKRAMLANNVLAVLGGALMGLANAAASYE--ILILGRFLIGAYSGlTSGLVPMYVG 161
Cdd:cd17326   42 VAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPSNRkyVMLVARFLIGVGAG-NVAVLRAYVA 120
                         90       100       110
                 ....*....|....*....|....*....|.
gi 118026925 162 EIAPTHLRGALGTLNQLAIVIGILVAQVLGL 192
Cdd:cd17326  121 AASTLKDRTRAMAVISAAQALGFIVGPALQA 151
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
82-190 5.84e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 5.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLAnnVLAVLGGALMGLANAAASYeILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:cd17370  237 PLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL--GYLSLALAYLGFALGSSLW-LLLLGFILWGLYMGAQESIERAAVA 313
                         90       100       110
                 ....*....|....*....|....*....|
gi 118026925 162 EIAPTHLRG-ALGTLNqLAIVIGILVAQVL 190
Cdd:cd17370  314 DLVPAELRGtAYGLFN-TVVGIGWLLASLI 342
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
83-209 6.73e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVGE 162
Cdd:cd17473  237 LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS---GLWVVLLGAILAGLGFGLLLPTLNSWAMS 313
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 118026925 163 IAPTHLRGALGTLNQLA---------IVIGILVAQVLGLESMLGTATLWPLLLALT 209
Cdd:cd17473  314 LVPPELRGRAMGIVTSAfflgqflspLVLGPLVNLTGGLSGAFLILGVLALVLAIV 369
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
79-191 1.07e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  79 TLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLannVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPM 158
Cdd:cd06173  244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL---IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 118026925 159 YVGEIAPTHLRG----ALGTLNQLAIVIGILVAQVLG 191
Cdd:cd06173  321 LLQLRVPDELRGrvfsVYNALNSGAMPLGALLAGLLA 357
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
82-233 1.82e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 40.57  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnaaASYEILILGRFLIGAYSGLTSGLVPMYvG 161
Cdd:cd17441   37 ALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFA---PIYSWILVLRGLVGFGIGGVPQSVTLY-A 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925 162 EIAPTHLRG----------ALGTLnqLAIVIGILVAQVLGlesmlgtatlWPLLLALTVLPALLQLILLPFCPESPRYLY 231
Cdd:cd17441  113 EFLPMKSRAkcillievfwALGTV--FEVLLAVFVMPTLG----------WRWLLILSALPLLIFAVLCFWLPESARYWT 180

                 ..
gi 118026925 232 II 233
Cdd:cd17441  181 TI 182
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
83-195 2.88e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILgrfLIGAYSGLTSGLVPMYVGE 162
Cdd:cd17329   39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV---LTGFGGGLFEPASEAMIAD 115
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 118026925 163 IAP----THLRGALGTLNQLAIVIGILVAQVLGLESM 195
Cdd:cd17329  116 VTTpenrTRAFSLLYWAINLGVAIGPLLGGLLLLYSF 152
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
335-446 3.09e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.67  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  335 VFTLVSVLLVERAGRRTLHLLGLAGMCGcailMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELfsqG 414
Cdd:TIGR00881 267 VGTLLAGWLSDKLFNGRRGPLAVFFMAL----IIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASEL---A 339
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 118026925  415 PRPAAMAVAGFSNWTCN---FIVGMGFQYVADAMG 446
Cdd:TIGR00881 340 PKKAAGTAAGFVGFFAYlggILAGLPLGYLADGFG 374
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
83-191 3.36e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.87  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  83 LSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANaaaSYEILILGRFLIGAYSGLTSGLVPMYVGE 162
Cdd:cd17320   38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS---SIEQLLIARFLQGLGAAAGSVVARAIVRD 114
                         90       100       110
                 ....*....|....*....|....*....|
gi 118026925 163 I-APTHLRGALGTLNqLAIVIGILVAQVLG 191
Cdd:cd17320  115 LySGAELAKIFSLLM-MILAIAPALAPLLG 143
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
82-210 3.82e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLAnAAASYEILILGrFLIGAYSGLTSGLVPMYVG 161
Cdd:cd17477  226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV-PGLPLALLVLL-FLWGGAAGPLYTLALALAG 303
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 118026925 162 EIAPTHLR----GALGTLNQLAIVIGILVAQVLGleSMLGTATLWPLLLALTV 210
Cdd:cd17477  304 DRLPGDELvaanAALLLLYGLGSVIGPLLAGALM--DAFGPHGLFLFLAAVAL 354
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
82-163 5.33e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.13  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118026925  82 ALSVAIFSVGGMISSFLIGIISQWLGRKRAMLAnnVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVG 161
Cdd:cd17353  252 ALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI--AFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA 329

                 ..
gi 118026925 162 EI 163
Cdd:cd17353  330 DF 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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