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Conserved domains on  [gi|22128623|ref|NP_033496|]
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uromodulin preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
336-584 3.15e-57

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 193.98  E-value: 3.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   336 CGANDIKMSLRKCQLQSLGFMN--VFMYLNDRQCSGFSESDERDWMSIVTParNGPCGTVLRRNETHATYSNTLYLANAI 413
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSslSLLGGLDPSCKPVSNTNGSPAVLFEFP--LTGCGTTVQVNGTHIIYSNTLYSSTDL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   414 IIR----DIIIRMNFECSYPLDMKVSLKTSLQPmvSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVG 489
Cdd:pfam00100  79 RSGiirrTITRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   490 TMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTT--IQVTENGESSQARFSVQMFRFAGNY-DLVYLH 566
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236

                         250
                  ....*....|....*...
gi 22128623   567 CEVYLCDSTSEQCKPTCS 584
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 111-147 9.14e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 9.14e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 22128623   111 CSEqGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYC 147
Cdd:pfam12947   1 CSD-NNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
65-98 3.90e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 3.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 22128623     65 DMDECATPwtHNCSN-SSCVNTPGSFKCSCQDGFR 98
Cdd:smart00179   1 DIDECASG--NPCQNgGTCVNTVGSYRCECPPGYT 33
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 35-63 1.92e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 1.92e-04
                          10        20
                  ....*....|....*....|....*....
gi 22128623    35 CHNNATCTVDGVVTTCSCQTGFTGDGLVC 63
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
336-584 3.15e-57

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 193.98  E-value: 3.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   336 CGANDIKMSLRKCQLQSLGFMN--VFMYLNDRQCSGFSESDERDWMSIVTParNGPCGTVLRRNETHATYSNTLYLANAI 413
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSslSLLGGLDPSCKPVSNTNGSPAVLFEFP--LTGCGTTVQVNGTHIIYSNTLYSSTDL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   414 IIR----DIIIRMNFECSYPLDMKVSLKTSLQPmvSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVG 489
Cdd:pfam00100  79 RSGiirrTITRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   490 TMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTT--IQVTENGESSQARFSVQMFRFAGNY-DLVYLH 566
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236

                         250
                  ....*....|....*...
gi 22128623   567 CEVYLCDSTSEQCKPTCS 584
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 335-584 5.85e-54

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 184.90  E-value: 5.85e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    335 ECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNgpCGTVLRRNETHATYSNTLYLA---N 411
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSpfhP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    412 AIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISlGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTeaFLYVGTM 491
Cdd:smart00241  79 GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSS-VSEGPLTCSYRLYKDDSFGSPYQSADYVLGD--PVYHEWE 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    492 LDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCP--RTEDTTIQVTENGESSqARFSVQMFRFAgNYDLVYLHCEV 569
Cdd:smart00241 156 CDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSNPLHR-ARFSVKVFKFA-DRSLVYFHCQI 233

                          250
                   ....*....|....*..
gi 22128623    570 YLCD--STSEQCKPTCS 584
Cdd:smart00241 234 RLCDkdDGSSCDGPACS 250
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 111-147 9.14e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 9.14e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 22128623   111 CSEqGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYC 147
Cdd:pfam12947   1 CSD-NNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 107-148 1.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 1.06e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22128623 107 DVDECSEQGlsNCHALATCVNTEGDYLCVCPEGFTGDgwYCE 148
Cdd:cd00054   1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
107-148 1.87e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.87e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 22128623    107 DVDECSEqgLSNCHALATCVNTEGDYLCVCPEGFTgDGWYCE 148
Cdd:smart00179   1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
65-98 3.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 3.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 22128623     65 DMDECATPwtHNCSN-SSCVNTPGSFKCSCQDGFR 98
Cdd:smart00179   1 DIDECASG--NPCQNgGTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
65-96 5.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 5.33e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 22128623    65 DMDECATPwTHNC-SNSSCVNTPGSFKCSCQDG 96
Cdd:pfam07645   1 DVDECATG-THNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 65-100 1.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.60e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 22128623  65 DMDECATPwtHNCSNS-SCVNTPGSFKCSCQDGFRLT 100
Cdd:cd00054   1 DIDECASG--NPCQNGgTCVNTVGSYRCSCPPGYTGR 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 35-63 1.92e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 1.92e-04
                          10        20
                  ....*....|....*....|....*....
gi 22128623    35 CHNNATCTVDGVVTTCSCQTGFTGDGLVC 63
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
336-584 3.15e-57

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 193.98  E-value: 3.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   336 CGANDIKMSLRKCQLQSLGFMN--VFMYLNDRQCSGFSESDERDWMSIVTParNGPCGTVLRRNETHATYSNTLYLANAI 413
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSslSLLGGLDPSCKPVSNTNGSPAVLFEFP--LTGCGTTVQVNGTHIIYSNTLYSSTDL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   414 IIR----DIIIRMNFECSYPLDMKVSLKTSLQPmvSALNISLGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTEAFLYVG 489
Cdd:pfam00100  79 RSGiirrTITRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623   490 TMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCPRTEDTT--IQVTENGESSQARFSVQMFRFAGNY-DLVYLH 566
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236

                         250
                  ....*....|....*...
gi 22128623   567 CEVYLCDSTSEQCKPTCS 584
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 335-584 5.85e-54

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 184.90  E-value: 5.85e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    335 ECGANDIKMSLRKCQLQSLGFMNVFMYLNDRQCSGFSESDERDWMSIVTPARNgpCGTVLRRNETHATYSNTLYLA---N 411
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSpfhP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    412 AIIIRDIIIRMNFECSYPLDMKVSLKTSLQPMVSALNISlGGTGKFTVRMALFQSPTYTQPHQGPSVMLSTeaFLYVGTM 491
Cdd:smart00241  79 GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSS-VSEGPLTCSYRLYKDDSFGSPYQSADYVLGD--PVYHEWE 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128623    492 LDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDSCP--RTEDTTIQVTENGESSqARFSVQMFRFAgNYDLVYLHCEV 569
Cdd:smart00241 156 CDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSNPLHR-ARFSVKVFKFA-DRSLVYFHCQI 233

                          250
                   ....*....|....*..
gi 22128623    570 YLCD--STSEQCKPTCS 584
Cdd:smart00241 234 RLCDkdDGSSCDGPACS 250
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 111-147 9.14e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 9.14e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 22128623   111 CSEqGLSNCHALATCVNTEGDYLCVCPEGFTGDGWYC 147
Cdd:pfam12947   1 CSD-NNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 107-148 1.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 1.06e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22128623 107 DVDECSEQGlsNCHALATCVNTEGDYLCVCPEGFTGDgwYCE 148
Cdd:cd00054   1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
107-148 1.87e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.87e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 22128623    107 DVDECSEqgLSNCHALATCVNTEGDYLCVCPEGFTgDGWYCE 148
Cdd:smart00179   1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
65-98 3.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 3.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 22128623     65 DMDECATPwtHNCSN-SSCVNTPGSFKCSCQDGFR 98
Cdd:smart00179   1 DIDECASG--NPCQNgGTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
65-96 5.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 5.33e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 22128623    65 DMDECATPwTHNC-SNSSCVNTPGSFKCSCQDG 96
Cdd:pfam07645   1 DVDECATG-THNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 65-100 1.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.60e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 22128623  65 DMDECATPwtHNCSNS-SCVNTPGSFKCSCQDGFRLT 100
Cdd:cd00054   1 DIDECASG--NPCQNGgTCVNTVGSYRCSCPPGYTGR 35
EGF_CA pfam07645
Calcium-binding EGF domain;
107-139 2.02e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 2.02e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 22128623   107 DVDECsEQGLSNCHALATCVNTEGDYLCVCPEG 139
Cdd:pfam07645   1 DVDEC-ATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 110-148 1.84e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 1.84e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 22128623 110 ECSEQGlsNCHALATCVNTEGDYLCVCPEGFTGDGwYCE 148
Cdd:cd00053   1 ECAASN--PCSNGGTCVNTPGSYRCVCPPGYTGDR-SCE 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 35-63 1.92e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 1.92e-04
                          10        20
                  ....*....|....*....|....*....
gi 22128623    35 CHNNATCTVDGVVTTCSCQTGFTGDGLVC 63
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 62-101 4.77e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 4.77e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 22128623  62 VCEDMDECATPwTHNCSNSsCVNTPGSFKCSCQDGFRLTP 101
Cdd:cd01475 183 ICVVPDLCATL-SHVCQQV-CISTPGSYLCACTEGYALLE 220
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 118-143 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 1.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 22128623   118 NCHALATCVNTEGDYLCVCPEGFTGD 143
Cdd:pfam00008   5 PCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF smart00181
Epidermal growth factor-like domain;
68-101 1.79e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 1.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 22128623     68 ECATPwtHNCSNSSCVNTPGSFKCSCQDGFRLTP 101
Cdd:smart00181   1 ECASG--GPCSNGTCINTPGSYTCSCPPGYTGDK 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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