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Conserved domains on  [gi|6678617|ref|NP_033561|]
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tyrosine-protein kinase Yes [Mus musculus]

Protein Classification

tyrosine-protein kinase Yes( domain architecture ID 10186266)

tyrosine-protein kinase Yes is a cytoplasmic (or nonreceptor) kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
262-540 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


:

Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 600.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  262 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 341
Cdd:cd05069   1 GLAKDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05069  81 IYIVTEFMGKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 501
Cdd:cd05069 161 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  502 LMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGEN 540
Cdd:cd05069 241 LMKLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGDN 279
SH2_Src_family cd09933
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src ...
152-251 3.59e-69

Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src family kinases are nonreceptor tyrosine kinases that have been implicated in pathways regulating proliferation, angiogenesis, invasion and metastasis, and bone metabolism. It is thought that transforming ability of Src is linked to its ability to activate key signaling molecules in these pathways, rather than through direct activity. As such blocking Src activation has been a target for drug companies. Src family members can be divided into 3 groups based on their expression pattern: 1) Src, Fyn, and Yes; 2) Blk, Fgr, Hck, Lck, and Lyn; and 3) Frk-related kinases Frk/Rak and Iyk/Bsk Of these, cellular c-Src is the best studied and most frequently implicated in oncogenesis. The c-Src contains five distinct regions: a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. Src exists in both active and inactive conformations. Negative regulation occurs through phosphorylation of Tyr, resulting in an intramolecular association between phosphorylated Tyr and the SH2 domain of SRC, which locks the protein in a closed conformation. Further stabilization of the inactive state occurs through interactions between the SH3 domain and a proline-rich stretch of residues within the kinase domain. Conversely, dephosphorylation of Tyr allows SRC to assume an open conformation. Full activity requires additional autophosphorylation of a Tyr residue within the catalytic domain. Loss of the negative-regulatory C-terminal segment has been shown to result in increased activity and transforming potential. Phosphorylation of the C-terminal Tyr residue by C-terminal Src kinase (Csk) and Csk homology kinase results in increased intramolecular interactions and consequent Src inactivation. Specific phosphatases, protein tyrosine phosphatase a (PTPa) and the SH-containing phosphatases SHP1/SHP2, have also been shown to take a part in Src activation. Src is also activated by direct binding of focal adhesion kinase (Fak) and Crk-associated substrate (Cas) to the SH2 domain. SRC activity can also be regulated by numerous receptor tyrosine kinases (RTKs), such as Her2, epidermal growth factor receptor (EGFR), fibroblast growth factor receptor, platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR). In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


:

Pssm-ID: 199827  Cd Length: 101  Bit Score: 217.06  E-value: 3.59e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd09933   1 EAEEWFFGKIKRKDAEKLLLAPGNPRGTFLIRESETTPGAYSLSVRDGDDARGDTVKHYRIRKLDNGGYYITTRATFPTL 80
                        90       100
                ....*....|....*....|
gi 6678617  232 QKLVKHYTEHADGLCHKLTT 251
Cdd:cd09933  81 QELVQHYSKDADGLCCRLTV 100
SH3_Yes cd12007
Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src ...
92-149 4.76e-38

Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


:

Pssm-ID: 212940 [Multi-domain]  Cd Length: 58  Bit Score: 133.62  E-value: 4.76e-38
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617   92 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPAD 149
Cdd:cd12007   1 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPAD 58
 
Name Accession Description Interval E-value
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
262-540 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 600.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  262 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 341
Cdd:cd05069   1 GLAKDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05069  81 IYIVTEFMGKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 501
Cdd:cd05069 161 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  502 LMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGEN 540
Cdd:cd05069 241 LMKLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGDN 279
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
275-524 2.27e-139

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 403.03  E-value: 2.27e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    275 LRLEVKLGQGCFGEVWMGTWNG-----TTKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVT 346
Cdd:pfam07714   1 LTLGEKLGEGAFGEVYKGTLKGegentKIKVAVKTLKEGADEEerEDFLEEASIMKKLDHPNIVKLLGVCTqGEPLYIVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    347 EFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-YT 425
Cdd:pfam07714  81 EYMPGGDLLDFLRKHKRK-LTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDyYR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    426 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:pfam07714 160 KRGGGKLPIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMSNEEVLEFLEDGYRLPQPENCPDELYDLMKQ 239
                         250
                  ....*....|....*....
gi 6678617    506 CWKKDPDERPTFEYIQSFL 524
Cdd:pfam07714 240 CWAYDPEDRPTFSELVEDL 258
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
275-524 2.93e-129

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 377.27  E-value: 2.93e-129
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     275 LRLEVKLGQGCFGEVWMGTWNGT-----TKVAIKTLKPGTMM--PEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVT 346
Cdd:smart00221   1 LTLGKKLGEGAFGEVYKGTLKGKgdgkeVEVAVKTLKEDASEqqIEEFLREARIMRKLDHPNIVKLLGVCTEeEPLMIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     347 EFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:smart00221  81 EYMPGGDLLDYLRKNRPKELSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     427 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:smart00221 161 VKGGKLPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEEPYPGMSNAEVLEYLKKGYRLPKPPNCPPELYKLMLQC 240
                          250
                   ....*....|....*...
gi 6678617     507 WKKDPDERPTFEYIQSFL 524
Cdd:smart00221 241 WAEDPEDRPTFSELVEIL 258
SH2_Src_family cd09933
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src ...
152-251 3.59e-69

Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src family kinases are nonreceptor tyrosine kinases that have been implicated in pathways regulating proliferation, angiogenesis, invasion and metastasis, and bone metabolism. It is thought that transforming ability of Src is linked to its ability to activate key signaling molecules in these pathways, rather than through direct activity. As such blocking Src activation has been a target for drug companies. Src family members can be divided into 3 groups based on their expression pattern: 1) Src, Fyn, and Yes; 2) Blk, Fgr, Hck, Lck, and Lyn; and 3) Frk-related kinases Frk/Rak and Iyk/Bsk Of these, cellular c-Src is the best studied and most frequently implicated in oncogenesis. The c-Src contains five distinct regions: a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. Src exists in both active and inactive conformations. Negative regulation occurs through phosphorylation of Tyr, resulting in an intramolecular association between phosphorylated Tyr and the SH2 domain of SRC, which locks the protein in a closed conformation. Further stabilization of the inactive state occurs through interactions between the SH3 domain and a proline-rich stretch of residues within the kinase domain. Conversely, dephosphorylation of Tyr allows SRC to assume an open conformation. Full activity requires additional autophosphorylation of a Tyr residue within the catalytic domain. Loss of the negative-regulatory C-terminal segment has been shown to result in increased activity and transforming potential. Phosphorylation of the C-terminal Tyr residue by C-terminal Src kinase (Csk) and Csk homology kinase results in increased intramolecular interactions and consequent Src inactivation. Specific phosphatases, protein tyrosine phosphatase a (PTPa) and the SH-containing phosphatases SHP1/SHP2, have also been shown to take a part in Src activation. Src is also activated by direct binding of focal adhesion kinase (Fak) and Crk-associated substrate (Cas) to the SH2 domain. SRC activity can also be regulated by numerous receptor tyrosine kinases (RTKs), such as Her2, epidermal growth factor receptor (EGFR), fibroblast growth factor receptor, platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR). In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 199827  Cd Length: 101  Bit Score: 217.06  E-value: 3.59e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd09933   1 EAEEWFFGKIKRKDAEKLLLAPGNPRGTFLIRESETTPGAYSLSVRDGDDARGDTVKHYRIRKLDNGGYYITTRATFPTL 80
                        90       100
                ....*....|....*....|
gi 6678617  232 QKLVKHYTEHADGLCHKLTT 251
Cdd:cd09933  81 QELVQHYSKDADGLCCRLTV 100
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
276-515 5.18e-46

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 168.27  E-value: 5.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPG-TMMPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFM 349
Cdd:COG0515  10 RILRLLGRGGMGVVYLARDLRLgRPVALKVLRPElAADPEArerFRREARALARLNHPNIVRVYDVGEEDGRpYLVMEYV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:COG0515  90 EGESLADLLRRR--GPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTGT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQ---GCPESLHELMNLC 506
Cdd:COG0515 168 VVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLT-GRPPFDGDSPAELLRAHLREPPPPPSElrpDLPPALDAIVLRA 246

                ....*....
gi 6678617  507 WKKDPDERP 515
Cdd:COG0515 247 LAKDPEERY 255
SH3_Yes cd12007
Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src ...
92-149 4.76e-38

Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212940 [Multi-domain]  Cd Length: 58  Bit Score: 133.62  E-value: 4.76e-38
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617   92 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPAD 149
Cdd:cd12007   1 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPAD 58
SH2 pfam00017
SH2 domain;
156-238 9.81e-34

SH2 domain;


Pssm-ID: 425423 [Multi-domain]  Cd Length: 77  Bit Score: 122.32  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    156 WYFGKMGRKDAERLLLNpGNQRGIFLVRESETTKGAYSLSIRDWDevrgdNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:pfam00017   1 WYHGKISRQEAERLLLN-GKPDGTFLVRESESTPGGYTLSVRDDG-----KVKHYKIQSTDNGGYYISGGVKFSSLAELV 74

                  ...
gi 6678617    236 KHY 238
Cdd:pfam00017  75 EHY 77
SH2 smart00252
Src homology 2 domains; Src homology 2 domains bind phosphotyrosine-containing polypeptides ...
154-244 1.35e-29

Src homology 2 domains; Src homology 2 domains bind phosphotyrosine-containing polypeptides via 2 surface pockets. Specificity is provided via interaction with residues that are distinct from the phosphotyrosine. Only a single occurrence of a SH2 domain has been found in S. cerevisiae.


Pssm-ID: 214585 [Multi-domain]  Cd Length: 84  Bit Score: 111.17  E-value: 1.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     154 EEWYFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGYYITTRAQFDTLQK 233
Cdd:smart00252   1 QPWYHGFISREEAEKLLKNEGD--GDFLVRDSESSPGDYVLSVRV-----KGKVKHYRIRRNEDGKFYLEGGRKFPSLVE 73
                           90
                   ....*....|.
gi 6678617     234 LVKHYTEHADG 244
Cdd:smart00252  74 LVEHYQKNSLG 84
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
300-473 1.90e-20

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 94.86  E-value: 1.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   300 VAIKTLKPgTMM--PEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFMsKGSLL-DFLKEGdGKyLKLPQLV 372
Cdd:NF033483  35 VAVKVLRP-DLArdPEFvarFRREAQSAASLSHPNIVSVYDVGEDGGIpYIVMEYV-DGRTLkDYIREH-GP-LSPEEAV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   373 DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIedNEYTARQGAKfpIKWTA----PEAALYGRFT 448
Cdd:NF033483 111 EIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARAL--SSTTMTQTNS--VLGTVhylsPEQARGGTVD 186
                        170       180
                 ....*....|....*....|....*
gi 6678617   449 IKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:NF033483 187 ARSDIYSLGIVLYEMLT-GRPPFDG 210
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
338-532 1.88e-18

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 88.15  E-value: 1.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   338 SEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD--MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGL 415
Cdd:PTZ00267 136 SDDKLLLIMEYGSGGDLNKQIKQRLKEHLPFQEYEVglLFYQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGF 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   416 ARLIEDNeYTARQGAKF---PIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRvPYPGMVNREVLEQVERGYRMPCP 492
Cdd:PTZ00267 216 SKQYSDS-VSLDVASSFcgtPY-YLAPELWERKRYSKKADMWSLGVILYELLTLHR-PFKGPSQREIMQQVLYGKYDPFP 292
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 6678617   493 QGCPESLHELMNLCWKKDPDERPT---------FEYIQSFLEDYFTATE 532
Cdd:PTZ00267 293 CPVSSGMKALLDPLLSKNPALRPTtqqllhtefLKYVANLFQDIVRHSE 341
SH3 smart00326
Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences ...
90-145 6.69e-18

Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.


Pssm-ID: 214620 [Multi-domain]  Cd Length: 56  Bit Score: 77.58  E-value: 6.69e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617      90 GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIaTGKSGYIPSNYV 145
Cdd:smart00326   1 EGPQVRALYDYTAQDPDELSFKKGDIITVLEKSDDGWWKGRLG-RGKEGLFPSNYV 55
SH3_1 pfam00018
SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal ...
95-142 6.39e-17

SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 394975 [Multi-domain]  Cd Length: 47  Bit Score: 74.55  E-value: 6.39e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6678617     95 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIaTGKSGYIPS 142
Cdd:pfam00018   1 VALYDYTAQEPDELSFKKGDIIIVLEKSEDGWWKGRNK-GGKEGLIPS 47
 
Name Accession Description Interval E-value
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
262-540 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 600.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  262 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 341
Cdd:cd05069   1 GLAKDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05069  81 IYIVTEFMGKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 501
Cdd:cd05069 161 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  502 LMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGEN 540
Cdd:cd05069 241 LMKLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGDN 279
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
279-526 0e+00

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 562.23  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  279 VKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 358
Cdd:cd14203   1 VKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEFMSKGSLLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  359 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 438
Cdd:cd14203  81 KDGEGKYLKLPQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  439 PEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14203 161 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPPGCPESLHELMCQCWRKDPEERPTFE 240

                ....*...
gi 6678617  519 YIQSFLED 526
Cdd:cd14203 241 YLQSFLED 248
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
280-525 0e+00

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 548.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFL 358
Cdd:cd05034   2 KLGAGQFGEVWMGVWNGTTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHDKLVQLYAVCSdEEPIYIVTELMSKGSLLDYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  359 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 438
Cdd:cd05034  82 RTGEGRALRLPQLIDMAAQIASGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLIEDDEYTAREGAKFPIKWTA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  439 PEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd05034 162 PEAALYGRFTIKSDVWSFGILLYEIVTYGRVPYPGMTNREVLEQVERGYRMPKPPGCPDELYDIMLQCWKKEPEERPTFE 241

                ....*..
gi 6678617  519 YIQSFLE 525
Cdd:cd05034 242 YLQSFLE 248
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
265-541 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 537.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  265 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI 344
Cdd:cd05071   1 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd05071  81 VTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd05071 161 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6678617  505 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 541
Cdd:cd05071 241 QCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 277
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
265-538 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 527.33  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  265 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI 344
Cdd:cd05070   1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd05070  81 VTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd05070 161 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  505 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 538
Cdd:cd05070 241 HCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPG 274
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
266-529 4.40e-177

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 499.24  E-value: 4.40e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYI 344
Cdd:cd05068   1 DQWEIDRKSLKLLRKLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPEDFLREAQIMKKLRHPKLIQLYAVCTlEEPIYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNE 423
Cdd:cd05068  81 ITELMKHGSLLEYL-QGKGRSLQLPQLIDMAAQVASGMAYLESQNYIHRDLAARNVLVGENNICKVADFGLARVIKvEDE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELM 503
Cdd:cd05068 160 YEAREGAKFPIKWTAPEAANYNRFSIKSDVWSFGILLTEIVTYGRIPYPGMTNAEVLQQVERGYRMPCPPNCPPQLYDIM 239
                       250       260
                ....*....|....*....|....*.
gi 6678617  504 NLCWKKDPDERPTFEYIQSFLEDYFT 529
Cdd:cd05068 240 LECWKADPMERPTFETLQWKLEDFFV 265
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
268-530 4.81e-166

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 471.29  E-value: 4.81e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTE 347
Cdd:cd05067   2 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAIKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTAR 427
Cdd:cd05067  82 YMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 507
Cdd:cd05067 162 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMPRPDNCPEELYQLMRLCW 241
                       250       260
                ....*....|....*....|...
gi 6678617  508 KKDPDERPTFEYIQSFLEDYFTA 530
Cdd:cd05067 242 KERPEDRPTFEYLRSVLEDFFTA 264
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
267-536 1.96e-161

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 459.89  E-value: 1.96e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  267 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIV 345
Cdd:cd05072   1 AWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTkEEPIYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYT 425
Cdd:cd05072  81 TEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd05072 161 AREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLYEIVTYGKIPYPGMSNSDVMSALQRGYRMPRMENCPDELYDIMKT 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  506 CWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536
Cdd:cd05072 241 CWKEKAEERPTFDYLQSVLDDFYTATEGQYQ 271
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
265-527 9.47e-148

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 424.82  E-value: 9.47e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  265 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI 344
Cdd:cd05073   3 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd05073  83 ITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd05073 163 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 242
                       250       260
                ....*....|....*....|...
gi 6678617  505 LCWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05073 243 RCWKNRPEERPTFEYIQSVLDDF 265
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
275-524 2.27e-139

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 403.03  E-value: 2.27e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    275 LRLEVKLGQGCFGEVWMGTWNG-----TTKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVT 346
Cdd:pfam07714   1 LTLGEKLGEGAFGEVYKGTLKGegentKIKVAVKTLKEGADEEerEDFLEEASIMKKLDHPNIVKLLGVCTqGEPLYIVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    347 EFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-YT 425
Cdd:pfam07714  81 EYMPGGDLLDFLRKHKRK-LTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDyYR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    426 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:pfam07714 160 KRGGGKLPIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMSNEEVLEFLEDGYRLPQPENCPDELYDLMKQ 239
                         250
                  ....*....|....*....
gi 6678617    506 CWKKDPDERPTFEYIQSFL 524
Cdd:pfam07714 240 CWAYDPEDRPTFSELVEDL 258
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
275-524 2.93e-129

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 377.27  E-value: 2.93e-129
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     275 LRLEVKLGQGCFGEVWMGTWNGT-----TKVAIKTLKPGTMM--PEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVT 346
Cdd:smart00221   1 LTLGKKLGEGAFGEVYKGTLKGKgdgkeVEVAVKTLKEDASEqqIEEFLREARIMRKLDHPNIVKLLGVCTEeEPLMIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     347 EFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:smart00221  81 EYMPGGDLLDYLRKNRPKELSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     427 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:smart00221 161 VKGGKLPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEEPYPGMSNAEVLEYLKKGYRLPKPPNCPPELYKLMLQC 240
                          250
                   ....*....|....*...
gi 6678617     507 WKKDPDERPTFEYIQSFL 524
Cdd:smart00221 241 WAEDPEDRPTFSELVEIL 258
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
275-524 4.07e-127

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 371.86  E-value: 4.07e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     275 LRLEVKLGQGCFGEVWMGTWNGT-----TKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVT 346
Cdd:smart00219   1 LTLGKKLGEGAFGEVYKGKLKGKggkkkVEVAVKTLKEDASEQqiEEFLREARIMRKLDHPNVVKLLGVCTEeEPLYIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     347 EFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:smart00219  81 EYMEGGDLLSYLRKNRPK-LSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYR 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     427 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:smart00219 160 KRGGKLPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMSNEEVLEYLKNGYRLPQPPNCPPELYDLMLQC 239
                          250
                   ....*....|....*...
gi 6678617     507 WKKDPDERPTFEYIQSFL 524
Cdd:smart00219 240 WAEDPEDRPTFSELVEIL 257
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
280-525 1.76e-123

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 362.63  E-value: 1.76e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTW----NGTTKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKG 352
Cdd:cd00192   2 KLGEGAFGEVYKGKLkggdGKTVDVAVKTLKEDASESErkDFLKEARVMKKLGHPNVVRLLGVcTEEEPLYLVMEYMEGG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKE-------GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-Y 424
Cdd:cd00192  82 DLLDFLRKsrpvfpsPEPSTLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSRDIYDDDyY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd00192 162 RKKTGGKLPIRWMAPESLKDGIFTSKSDVWSFGVLLWEIFTLGATPYPGLSNEEVLEYLRKGYRLPKPENCPDELYELML 241
                       250       260
                ....*....|....*....|.
gi 6678617  505 LCWKKDPDERPTFEYIQSFLE 525
Cdd:cd00192 242 SCWQLDPEDRPTFSELVERLE 262
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
268-527 1.30e-122

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 360.60  E-value: 1.30e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIV 345
Cdd:cd05148   1 WERPREEFTLERKLGSGYFGEVWEGLWKNRVRVAIKILKSDDLLKqQDFQKEVQALKRLRHKHLISLFAVCSVgEPVYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYT 425
Cdd:cd05148  81 TELMEKGSLLAFLRSPEGQVLPVASLIDMACQVAEGMAYLEEQNSIHRDLAARNILVGEDLVCKVADFGLARLIKEDVYL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ArQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd05148 161 S-SDKKIPYKWTAPEAASHGTFSTKSDVWSFGILLYEMFTYGQVPYPGMNNHEVYDQITAGYRMPCPAKCPQEIYKIMLE 239
                       250       260
                ....*....|....*....|..
gi 6678617  506 CWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05148 240 CWAAEPEDRPSFKALREELDNI 261
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
268-528 6.59e-106

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 317.83  E-value: 6.59e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 345
Cdd:cd05052   1 WEIERTDITMKHKLGGGQYGEVYEGVWKKYNLtVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREpPFYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYT 425
Cdd:cd05052  81 TEFMPYGNLLDYLRECNREELNAVVLLYMATQIASAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd05052 161 AHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKGYRMERPEGCPPKVYELMRA 240
                       250       260
                ....*....|....*....|...
gi 6678617  506 CWKKDPDERPTFEYIQSFLEDYF 528
Cdd:cd05052 241 CWQWNPSDRPSFAEIHQALETMF 263
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
274-517 2.43e-103

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 311.30  E-value: 2.43e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKG 352
Cdd:cd05059   5 ELTFLKELGSGQFGVVHLGKWRGKIDVAIKMIKEGSMSEDDFIEEAKVMMKLSHPKLVQLYGVCTKQrPIFIVTEYMANG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF 432
Cdd:cd05059  85 CLLNYLRERRGK-FQTEQLLEMCKDVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDDEYTSSVGTKF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 512
Cdd:cd05059 164 PVKWSPPEVFMYSKFSSKSDVWSFGVLMWEVFSEGKMPYERFSNSEVVEHISQGYRLYRPHLAPTEVYTIMYSCWHEKPE 243

                ....*
gi 6678617  513 ERPTF 517
Cdd:cd05059 244 ERPTF 248
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
268-525 1.65e-100

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 303.89  E-value: 1.65e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTtKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVT 346
Cdd:cd05039   1 WAINKKDLKLGELIGKGEFGDVMLGDYRGQ-KVAVKCLKDDSTAAQAFLAEASVMTTLRHPNLVQLLGVVLEGnGLYIVT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEyta 426
Cdd:cd05039  80 EYMAKGSLVDYLRSRGRAVITRKDQLGFALDVCEGMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFGLAKEASSNQ--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 rQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd05039 157 -DGGKLPIKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPHVEKGYRMEAPEGCPPEVYKVMKNC 235
                       250
                ....*....|....*....
gi 6678617  507 WKKDPDERPTFEYIQSFLE 525
Cdd:cd05039 236 WELDPAKRPTFKQLREKLE 254
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
280-521 1.43e-98

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 298.59  E-value: 1.43e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPgTMMPE---AFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSL 354
Cdd:cd05041   2 KIGRGNFGDVYRGVLKPDnTEVAVKTCRE-TLPPDlkrKFLQEARILKQYDHPNIVKLIGVcVQKQPIMIVMELVPGGSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKeGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK-FP 433
Cdd:cd05041  81 LTFLR-KKGARLTVKQLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMSREEEDGEYTVSDGLKqIP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd05041 160 IKWTAPEALNYGRYTSESDVWSFGILLWEIFSLGATPYPGMSNQQTREQIESGYRMPAPELCPEAVYRLMLQCWAYDPEN 239

                ....*...
gi 6678617  514 RPTFEYIQ 521
Cdd:cd05041 240 RPSFSEIY 247
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
270-527 2.55e-93

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 285.81  E-value: 2.55e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPG--TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPI 342
Cdd:cd05033   1 IDASYVTIEKVIGGGEFGEVCSGSLKLPGKkeidVAIKTLKSGysDKQRLDFLTEASIMGQFDHPNVIRLEGVVTKsRPV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd05033  81 MIVTEYMENGSLDKFLRENDGK-FTVTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSRRLEDS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 E--YTARqGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLH 500
Cdd:cd05033 160 EatYTTK-GGKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSYGERPYWDMSNQDVIKAVEDGYRLPPPMDCPSALY 238
                       250       260
                ....*....|....*....|....*..
gi 6678617  501 ELMNLCWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05033 239 QLMLDCWQKDRNERPTFSQIVSTLDKM 265
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
271-517 6.12e-91

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 279.14  E-value: 6.12e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PREsLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFM 349
Cdd:cd05112   3 PSE-LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQaPICLVFEFM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:cd05112  82 EHGCLSDYLRTQRGLFSA-ETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVVKVSDFGMTRFVLDDQYTSSTG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKK 509
Cdd:cd05112 161 TKFPVKWSSPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDINAGFRLYKPRLASTHVYEIMNHCWKE 240

                ....*...
gi 6678617  510 DPDERPTF 517
Cdd:cd05112 241 RPEDRPSF 248
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
268-526 2.66e-85

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 265.36  E-value: 2.66e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVVS- 338
Cdd:cd05032   1 WELPREKITLIRELGQGSFGMVYEGLAKGVvkgepeTRVAIKTVNENASMREriEFLNEASVMKEFNCHHVVRLLGVVSt 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EEPIYIVTEFMSKGSLLDFLKE--------GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd05032  81 GQPTLVVMELMAKGDLKSYLRSrrpeaennPGLGPPTLQKFIQMAAEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEYTaRQGAK--FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYR 488
Cdd:cd05032 161 GDFGMTRDIYETDYY-RKGGKglLPVRWMAPESLKDGVFTTKSDVWSFGVVLWEMATLAEQPYQGLSNEEVLKFVIDGGH 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6678617  489 MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05032 240 LDLPENCPDKLLELMRMCWQYNPKMRPTFLEIVSSLKD 277
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
281-524 2.62e-83

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 259.01  E-value: 2.62e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLD 356
Cdd:cd13999   1 IGSGSFGEVYKGKWRGT-DVAIKKLKVEDDNDellKEFRREVSILSKLRHPNIVQFIGACLSPPpLCIVTEYMPGGSLYD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY--TARQGAkfpI 434
Cdd:cd13999  80 LLHKKK-IPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKNSTTEkmTGVVGT---P 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd13999 156 RWMAPEVLRGEPYTEKADVYSFGIVLWELLT-GEVPFKELSPIQIAAAVvQKGLRPPIPPDCPPELSKLIKRCWNEDPEK 234
                       250
                ....*....|.
gi 6678617  514 RPTFEYIQSFL 524
Cdd:cd13999 235 RPSFSEIVKRL 245
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
270-525 3.24e-83

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 259.43  E-value: 3.24e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEF 348
Cdd:cd05113   1 IDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQrPIFIITEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEGdGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ 428
Cdd:cd05113  81 MANGCLLNYLREM-RKRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd05113 160 GSKFPVRWSPPEVLMYSKFSSKSDVWAFGVLMWEVYSLGKMPYERFTNSETVEHVSQGLRLYRPHLASEKVYTIMYSCWH 239
                       250
                ....*....|....*..
gi 6678617  509 KDPDERPTFEYIQSFLE 525
Cdd:cd05113 240 EKADERPTFKILLSNIL 256
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
275-525 2.09e-81

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 255.18  E-value: 2.09e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTE 347
Cdd:cd05066   6 IKIEKVIGAGEFGEVCSGRLKLPGKreipVAIKTLKAGYTEKQRrdFLSEASIMGQFDHPNIIHLEGVVTRsKPVMIVTE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDGKYLKLpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN---EY 424
Cdd:cd05066  86 YMENGSLDAFLRKHDGQFTVI-QLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDpeaAY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARqGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd05066 165 TTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWEMSNQDVIKAIEEGYRLPAPMDCPAALHQLML 243
                       250       260
                ....*....|....*....|.
gi 6678617  505 LCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05066 244 DCWQKDRNERPKFEQIVSILD 264
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
268-526 2.16e-81

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 254.52  E-value: 2.16e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTtKVAIKTLKpGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP--IYIV 345
Cdd:cd05082   1 WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKggLYIV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYT 425
Cdd:cd05082  79 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ArqgaKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd05082 159 G----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 234
                       250       260
                ....*....|....*....|.
gi 6678617  506 CWKKDPDERPTFEYIQSFLED 526
Cdd:cd05082 235 CWHLDAAMRPSFLQLREQLEH 255
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
281-524 3.82e-81

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 253.77  E-value: 3.82e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGtmMPEA----FLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSLL 355
Cdd:cd05085   4 LGKGNFGEVYKGTLKDKTPVAVKTCKED--LPQElkikFLSEARILKQYDHPNIVKLIGVCTQrQPIYIVMELVPGGDFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK 435
Cdd:cd05085  82 SFLRKKKDE-LKTKQLVKFSLDAAAGMAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQIPIK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERP 515
Cdd:cd05085 161 WTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVEKGYRMSAPQRCPEDIYKIMQRCWDYNPENRP 240

                ....*....
gi 6678617  516 TFEYIQSFL 524
Cdd:cd05085 241 KFSELQKEL 249
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
280-518 3.43e-80

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 251.70  E-value: 3.43e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFL 358
Cdd:cd05114  11 ELGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHPKLVQLYGVCTQQkPIYIVTEFMENGCLLNYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  359 KEGDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 438
Cdd:cd05114  91 RQRRGKLSR-DMLLSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSSGAKFPVKWSP 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  439 PEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd05114 170 PEVFNYSKFSSKSDVWSFGVLMWEVFTEGKMPFESKSNYEVVEMVSRGHRLYRPKLASKSVYEVMYSCWHEKPEGRPTFA 249
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
281-526 4.35e-80

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 251.57  E-value: 4.35e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-------NGTTKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMS 350
Cdd:cd05044   3 LGSGAFGEVFEGTAkdilgdgSGETKVAVKTLRKGATDQEkaEFLKEAHLMSNFKHPNILKLLGVcLDNDPQYIILELME 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKE-----GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN----LICKIADFGLARLIED 421
Cdd:cd05044  83 GGDLLSYLRAarptaFTPPLLTLKDLLSICVDVAKGCVYLEDMHFVHRDLAARNCLVSSKdyreRVVKIGDFGLARDIYK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLH 500
Cdd:cd05044 163 NDYYRKEGeGLLPVRWMAPESLVDGVFTTQSDVWAFGVLMWEILTLGQQPYPARNNLEVLHFVRAGGRLDQPDNCPDDLY 242
                       250       260
                ....*....|....*....|....*.
gi 6678617  501 ELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05044 243 ELMLRCWSTDPEERPSFARILEQLQN 268
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
281-527 9.31e-80

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 250.34  E-value: 9.31e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW----NGTTKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd05060   3 LGHGNFGSVRKGVYlmksGKEVEVAVKTLKQEHEKAgkKEFLREASVMAQLDHPCIVRLIGVCKGEPLMLVMELAPLGPL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYTARQGAKF 432
Cdd:cd05060  83 LKYLK--KRREIPVSDLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGMSRALgaGSDYYRATTAGRW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 512
Cdd:cd05060 161 PLKWYAPECINYGKFSSKSDVWSYGVTLWEAFSYGAKPYGEMKGPEVIAMLESGERLPRPEECPQEIYSIMLSCWKYRPE 240
                       250
                ....*....|....*
gi 6678617  513 ERPTFEYIQSFLEDY 527
Cdd:cd05060 241 DRPTFSELESTFRRD 255
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
275-525 1.33e-78

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 247.86  E-value: 1.33e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTE 347
Cdd:cd05065   6 VKIEEVIGAGEFGEVCRGRLKLPGKreifVAIKTLKSGYTEKQRrdFLSEASIMGQFDHPNIIHLEGVVTKSrPVMIITE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDGKYLKLpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE---- 423
Cdd:cd05065  86 FMENGALDSFLRQNDGQFTVI-QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsdpt 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELM 503
Cdd:cd05065 165 YTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPTALHQLM 244
                       250       260
                ....*....|....*....|..
gi 6678617  504 NLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05065 245 LDCWQKDRNLRPKFGQIVNTLD 266
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
269-525 1.31e-77

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 245.27  E-value: 1.31e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVPLYAVVSE-EP 341
Cdd:cd05063   1 EIHPSHITKQKVIGAGEFGEVFRGILKMPGRkevaVAIKTLKPGYTEKQRqdFLSEASIMGQFSHHNIIRLEGVVTKfKP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKYLKLpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05063  81 AMIITEYMENGALDKYLRDHDGEFSSY-QLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVSDFGLSRVLED 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 N---EYTArQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 498
Cdd:cd05063 160 DpegTYTT-SGGKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSFGERPYWDMSNHEVMKAINDGFRLPAPMDCPSA 238
                       250       260
                ....*....|....*....|....*..
gi 6678617  499 LHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05063 239 VYQLMLQCWQQDRARRPRFVDIVNLLD 265
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
268-525 1.87e-77

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 244.40  E-value: 1.87e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTtKVAIKTLKpGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTE 347
Cdd:cd05083   1 WLLNLQKLTLGEIIGEGEFGAVLQGEYMGQ-KVAVKNIK-CDVTAQAFLEETAVMTKLQHKNLVRLLGVILHNGLYIVME 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLiednEYTAR 427
Cdd:cd05083  79 LMSKGNLVNFLRSRGRALVPVIQLLQFSLDVAEGMEYLESKKLVHRDLAARNILVSEDGVAKISDFGLAKV----GSMGV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 507
Cdd:cd05083 155 DNSRLPVKWTAPEALKNKKFSSKSDVWSYGVLLWEVFSYGRAPYPKMSVKEVKEAVEKGYRMEPPEGCPPDVYSIMTSCW 234
                       250
                ....*....|....*...
gi 6678617  508 KKDPDERPTFEYIQSFLE 525
Cdd:cd05083 235 EAEPGKRPSFKKLREKLE 252
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
280-526 1.56e-76

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 242.25  E-value: 1.56e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTW---NGTT-KVAIKTLKPGTMM----PEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSK 351
Cdd:cd05040   2 KLGDGSFGVVRRGEWttpSGKViQVAVKCLKSDVLSqpnaMDDFLKEVNAMHSLDHPNLIRLYGVVLSSPLMMVTELAPL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLkLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE--YTARQG 429
Cdd:cd05040  82 GSLLDRLRKDQGHFL-ISTLCDYAVQIANGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLMRALPQNEdhYVMQEH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER-GYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd05040 161 RKVPFAWCAPESLKTRKFSHASDVWMFGVTLWEMFTYGEEPWLGLNGSQILEKIDKeGERLERPDDCPQDIYNVMLQCWA 240
                       250
                ....*....|....*...
gi 6678617  509 KDPDERPTFEYIQSFLED 526
Cdd:cd05040 241 HKPADRPTFVALRDFLPE 258
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
268-526 6.86e-75

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 238.48  E-value: 6.86e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTKVAIKTLKPGTM--MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 341
Cdd:cd05056   1 YEIQREDITLGRCIGEGQFGDVYQGVYmspeNEKIAVAVKTCKNCTSpsVREKFLQEAYIMRQFDHPHIVKLIGVITENP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05056  81 VWIVMELAPLGELRSYLQV-NKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYMED 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 501
Cdd:cd05056 160 ESYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMLGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYS 239
                       250       260
                ....*....|....*....|....*
gi 6678617  502 LMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05056 240 LMTKCWAYDPSKRPRFTELKAQLSD 264
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
280-524 2.67e-74

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 236.37  E-value: 2.67e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNG-TTKVAIKTLKPgTMMPE---AFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSL 354
Cdd:cd05084   3 RIGRGNFGEVFSGRLRAdNTPVAVKSCRE-TLPPDlkaKFLQEARILKQYSHPNIVRLIGVCTQkQPIYIVMELVQGGDF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK-FP 433
Cdd:cd05084  82 LTFLRT-EGPRLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDGVYAATGGMKqIP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd05084 161 VKWTAPEALNYGRYSSESDVWSFGILLWETFSLGAVPYANLSNQQTREAVEQGVRLPCPENCPDEVYRLMEQCWEYDPRK 240
                       250
                ....*....|.
gi 6678617  514 RPTFEYIQSFL 524
Cdd:cd05084 241 RPSFSTVHQDL 251
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
269-520 3.75e-74

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 236.52  E-value: 3.75e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTT------KVAIKTLkPGTMMPEA---FLQEAQIMKKLRHDKLVPLYAV-VS 338
Cdd:cd05036   2 EVPRKNLTLIRALGQGAFGEVYEGTVSGMPgdpsplQVAVKTL-PELCSEQDemdFLMEALIMSKFNHPNIVRCIGVcFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EEPIYIVTEFMSKGSLLDFLKE-----GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKI 410
Cdd:cd05036  81 RLPRFILLELMAGGDLKSFLREnrprpEQPSSLTMLDLLQLAQDVAKGCRYLEENHFIHRDIAARNCLLtckGPGRVAKI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRM 489
Cdd:cd05036 161 GDFGMARDIYRADYYRKGGkAMLPVKWMPPEAFLDGIFTSKTDVWSFGVLLWEIFSLGYMPYPGKSNQEVMEFVTSGGRM 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  490 PCPQGCPESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd05036 241 DPPKNCPGPVYRIMTQCWQHIPEDRPNFSTI 271
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
267-525 1.42e-73

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 235.77  E-value: 1.42e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  267 AWEIPRESLRLEVKLGQGCFGEVWMGTW-------NGTTKVAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAV 336
Cdd:cd05053   6 EWELPRDRLTLGKPLGEGAFGQVVKAEAvgldnkpNEVVTVAVKMLKDDATEKDLsdLVSEMEMMKMIgKHKNIINLLGA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEE-PIYIVTEFMSKGSLLDFLK--------------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL 401
Cdd:cd05053  86 CTQDgPLYVVVEYASKGNLREFLRarrppgeeaspddpRVPEEQLTQKDLVSFAYQVARGMEYLASKKCIHRDLAARNVL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  402 VGENLICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAaLYGR-FTIKSDVWSFGILQTELVTKGRVPYPGMVNREV 479
Cdd:cd05053 166 VTEDNVMKIADFGLARDIHHIDYYRKTTnGRLPVKWMAPEA-LFDRvYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  480 LEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05053 245 FKLLKEGHRMEKPQNCTQELYMLMRDCWHEVPSQRPTFKQLVEDLD 290
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
269-524 1.33e-70

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 227.64  E-value: 1.33e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNG------TTKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVS-E 339
Cdd:cd05048   1 EIPLSAVRFLEELGEGAFGKVYKGELLGpsseesAISVAIKTLKENASPKtqQDFRREAELMSDLQHPNIVCLLGVCTkE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 EPIYIVTEFMSKGSLLDFL--------------KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN 405
Cdd:cd05048  81 QPQCMLFEYMAHGDLHEFLvrhsphsdvgvssdDDGTASSLDQSDFLHIAIQIAAGMEYLSSHHYVHRDLAARNCLVGDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  406 LICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE 484
Cdd:cd05048 161 LTVKISDFGLSRDIYSSDYYRVQSkSLLPVRWMPPEAILYGKFTTESDVWSFGVVLWEIFSYGLQPYYGYSNQEVIEMIR 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6678617  485 RGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05048 241 SRQLLPCPEDCPARVYSLMVECWHEIPSRRPRFKEIHTRL 280
SH2_Src_family cd09933
Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src ...
152-251 3.59e-69

Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases; The Src family kinases are nonreceptor tyrosine kinases that have been implicated in pathways regulating proliferation, angiogenesis, invasion and metastasis, and bone metabolism. It is thought that transforming ability of Src is linked to its ability to activate key signaling molecules in these pathways, rather than through direct activity. As such blocking Src activation has been a target for drug companies. Src family members can be divided into 3 groups based on their expression pattern: 1) Src, Fyn, and Yes; 2) Blk, Fgr, Hck, Lck, and Lyn; and 3) Frk-related kinases Frk/Rak and Iyk/Bsk Of these, cellular c-Src is the best studied and most frequently implicated in oncogenesis. The c-Src contains five distinct regions: a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. Src exists in both active and inactive conformations. Negative regulation occurs through phosphorylation of Tyr, resulting in an intramolecular association between phosphorylated Tyr and the SH2 domain of SRC, which locks the protein in a closed conformation. Further stabilization of the inactive state occurs through interactions between the SH3 domain and a proline-rich stretch of residues within the kinase domain. Conversely, dephosphorylation of Tyr allows SRC to assume an open conformation. Full activity requires additional autophosphorylation of a Tyr residue within the catalytic domain. Loss of the negative-regulatory C-terminal segment has been shown to result in increased activity and transforming potential. Phosphorylation of the C-terminal Tyr residue by C-terminal Src kinase (Csk) and Csk homology kinase results in increased intramolecular interactions and consequent Src inactivation. Specific phosphatases, protein tyrosine phosphatase a (PTPa) and the SH-containing phosphatases SHP1/SHP2, have also been shown to take a part in Src activation. Src is also activated by direct binding of focal adhesion kinase (Fak) and Crk-associated substrate (Cas) to the SH2 domain. SRC activity can also be regulated by numerous receptor tyrosine kinases (RTKs), such as Her2, epidermal growth factor receptor (EGFR), fibroblast growth factor receptor, platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR). In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 199827  Cd Length: 101  Bit Score: 217.06  E-value: 3.59e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd09933   1 EAEEWFFGKIKRKDAEKLLLAPGNPRGTFLIRESETTPGAYSLSVRDGDDARGDTVKHYRIRKLDNGGYYITTRATFPTL 80
                        90       100
                ....*....|....*....|
gi 6678617  232 QKLVKHYTEHADGLCHKLTT 251
Cdd:cd09933  81 QELVQHYSKDADGLCCRLTV 100
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
267-526 8.00e-69

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 223.52  E-value: 8.00e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  267 AWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTKVAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVV 337
Cdd:cd05055  29 KWEFPRNNLSFGKTLGAGAFGKVVEATAYGlsksdaVMKVAVKMLKPTAHSSEreALMSELKIMSHLgNHENIVNLLGAC 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  338 SEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA 416
Cdd:cd05055 109 TIGgPILVITEYCCYGDLLNFLRRKRESFLTLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICDFGLA 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLI-EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQG 494
Cdd:cd05055 189 RDImNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGILLWEIFSLGSNPYPGMpVDSKFYKLIKEGYRMAQPEH 268
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  495 CPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05055 269 APAEIYDIMKTCWDADPLKRPTFKQIVQLIGK 300
PTKc_DDR cd05051
Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze ...
269-524 1.00e-68

Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The DDR subfamily consists of homologs of mammalian DDR1, DDR2, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270644 [Multi-domain]  Cd Length: 297  Bit Score: 223.37  E-value: 1.00e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEV---------------WMGTWNGTTK--VAIKTLKPGT--MMPEAFLQEAQIMKKLRHDK 329
Cdd:cd05051   1 EFPREKLEFVEKLGEGQFGEVhlceanglsdltsddFIGNDNKDEPvlVAVKMLRPDAskNAREDFLKEVKIMSQLKDPN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  330 LVPLYAV-VSEEPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQ--------LVDMAAQIADGMAYIERMNYIHRDLRAA 398
Cdd:cd05051  81 IVRLLGVcTRDEPLCMIVEYMENGDLNQFLQkhEAETQGASATNsktlsygtLLYMATQIASGMKYLESLNFVHRDLATR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  399 NILVGENLICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRV-PYPGMVN 476
Cdd:cd05051 161 NCLVGPNYTIKIADFGMSRNLYSGDYYRIEGrAVLPIRWMAWESILLGKFTTKSDVWAFGVTLWEILTLCKEqPYEHLTD 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  477 REVLEQVERGYR-------MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05051 241 EQVIENAGEFFRddgmevyLSRPPNCPKEIYELMLECWRRDEEDRPTFREIHLFL 295
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
270-523 3.32e-66

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 216.13  E-value: 3.32e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRES-LRLEVKLGQGCFGEVWMGTW-----NGTTKVAIKTLKPGT--MMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP 341
Cdd:cd05057   3 IVKETeLEKGKVLGSGAFGTVYKGVWipegeKVKIPVAIKVLREETgpKANEEILDEAYVMASVDHPHLVRLLGICLSSQ 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE- 420
Cdd:cd05057  83 VQLITQLMPLGCLLDYVRNHRDN-IGSQLLLNWCVQIAKGMSYLEEKRLVHRDLAARNVLVKTPNHVKITDFGLAKLLDv 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 -DNEYTArQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05057 162 dEKEYHA-EGGKVPIKWMALESIQYRIYTHKSDVWSYGVTVWELMTFGAKPYEGIPAVEIPDLLEKGERLPQPPICTIDV 240
                       250       260
                ....*....|....*....|....*
gi 6678617  500 HELMNLCWKKDPDERPTF-EYIQSF 523
Cdd:cd05057 241 YMVLVKCWMIDAESRPTFkELANEF 265
SH2_Src_Yes cd10366
Src homology 2 (SH2) domain found in Yes; Yes is a member of the Src non-receptor type ...
152-252 3.33e-66

Src homology 2 (SH2) domain found in Yes; Yes is a member of the Src non-receptor type tyrosine kinase family of proteins. Yes is the cellular homolog of the Yamaguchi sarcoma virus oncogene. In humans it is encoded by the YES1 gene which maps to chromosome 18 and is in close proximity to thymidylate synthase. A corresponding Yes pseudogene has been found on chromosome 22. YES1 has been shown to interact with Janus kinase 2, CTNND1,RPL10, and Occludin. Yes1 has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198229  Cd Length: 101  Bit Score: 209.49  E-value: 3.33e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10366   1 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 80
                        90       100
                ....*....|....*....|.
gi 6678617  232 QKLVKHYTEHADGLCHKLTTV 252
Cdd:cd10366  81 QKLVKHYTEHADGLCHKLTTV 101
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
269-525 2.58e-64

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 211.61  E-value: 2.58e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGT------TKVAIKTLKPG--TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE- 339
Cdd:cd05050   1 EYPRNNIEYVRDIGQGAFGRVFQARAPGLlpyepfTMVAVKMLKEEasADMQADFQREAALMAEFDHPNIVKLLGVCAVg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 EPIYIVTEFMSKGSLLDFLKEG------------------DGKYLKL--PQLVDMAAQIADGMAYIERMNYIHRDLRAAN 399
Cdd:cd05050  81 KPMCLLFEYMAYGDLNEFLRHRspraqcslshstssarkcGLNPLPLscTEQLCIAKQVAAGMAYLSERKFVHRDLATRN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  400 ILVGENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 478
Cdd:cd05050 161 CLVGENMVVKIADFGLSRNIYSADYyKASENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEE 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  479 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05050 241 VIYYVRDGNVLSCPDNCPLELYNLMRLCWSKLPSDRPSFASINRILQ 287
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
271-521 5.76e-64

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 210.32  E-value: 5.76e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTW----NGTTK-VAIKTLKPgtMMPEA----FLQEAQIMKKLRHDKLVPlYAVVSEEP 341
Cdd:cd05038   2 EERHLKFIKQLGEGHFGSVELCRYdplgDNTGEqVAVKSLQP--SGEEQhmsdFKREIEILRTLDHEYIVK-YKGVCESP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 ----IYIVTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR 417
Cdd:cd05038  79 grrsLRLIMEYLPSGSLRDYLQRHRDQ-IDLKRLLLFASQICKGMEYLGSQRYIHRDLAARNILVESEDLVKISDFGLAK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  418 LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR---VPYP-----------GMVNREVLE 481
Cdd:cd05038 158 VLPEDKeyYYVKEPGESPIFWYAPECLRESRFSSASDVWSFGVTLYELFTYGDpsqSPPAlflrmigiaqgQMIVTRLLE 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6678617  482 QVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 521
Cdd:cd05038 238 LLKSGERLPRPPSCPDEVYDLMKECWEYEPQDRPSFSDLI 277
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
268-535 6.14e-64

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 211.36  E-value: 6.14e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK--------VAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAV 336
Cdd:cd05099   7 WEFPRDRLVLGKPLGEGCFGQVVRAEAYGIDKsrpdqtvtVAVKMLKDNATDKDLadLISEMELMKLIgKHKNIINLLGV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEE-PIYIVTEFMSKGSLLDFLK--------------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL 401
Cdd:cd05099  87 CTQEgPLYVIVEYAAKGNLREFLRarrppgpdytfditKVPEEQLSFKDLVSCAYQVARGMEYLESRRCIHRDLAARNVL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  402 VGENLICKIADFGLARLIEDNEYTAR-QGAKFPIKWTAPEAaLYGR-FTIKSDVWSFGILQTELVTKGRVPYPGMVNREV 479
Cdd:cd05099 167 VTEDNVMKIADFGLARGVHDIDYYKKtSNGRLPVKWMAPEA-LFDRvYTHQSDVWSFGILMWEIFTLGGSPYPGIPVEEL 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  480 LEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQY 535
Cdd:cd05099 246 FKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLVEALDKVLAAVSEEY 301
PTKc_EphR_A10 cd05064
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the ...
269-524 7.27e-64

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphA10, which contains an inactive tyr kinase domain, may function to attenuate signals of co-clustered active receptors. EphA10 is mainly expressed in the testis. Ephrin/EphR interaction results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). In general, class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The EphA10 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133195 [Multi-domain]  Cd Length: 266  Bit Score: 209.39  E-value: 7.27e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK----VAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVVSE-EP 341
Cdd:cd05064   1 ELDNKSIKIERILGTGRFGELCRGCLKLPSKrelpVAIHTLRAGCSDKQrrGFLAEALTLGQFDHSNIVRLEGVITRgNT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGlaRLIED 421
Cdd:cd05064  81 MMIVTEYMSNGALDSFLRKHEGQ-LVAGQLMGMLPGLASGMKYLSEMGYVHKGLAAHKVLVNSDLVCKISGFR--RLQED 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NE---YTARQGaKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 498
Cdd:cd05064 158 KSeaiYTTMSG-KSPVLWAAPEAIQYHHFSSASDVWSFGIVMWEVMSYGERPYWDMSGQDVIKAVEDGFRLPAPRNCPNL 236
                       250       260
                ....*....|....*....|....*.
gi 6678617  499 LHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05064 237 LHQLMLDCWQKERGERPRFSQIHSIL 262
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
269-524 1.59e-63

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 209.24  E-value: 1.59e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTW------NGTTKVAIKTLKPGTM--MPEAFLQEAQIMKKLRHDKLVPLYAVVSE- 339
Cdd:cd05049   1 HIKRDTIVLKRELGEGAFGKVFLGECynlepeQDKMLVAVKTLKDASSpdARKDFEREAELLTNLQHENIVKFYGVCTEg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 EPIYIVTEFMSKGSLLDFLK------------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLI 407
Cdd:cd05049  81 DPLLMVFEYMEHGDLNKFLRshgpdaaflaseDSAPGELTLSQLLHIAVQIASGMVYLASQHFVHRDLATRNCLVGTNLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  408 CKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERG 486
Cdd:cd05049 161 VKIGDFGMSRDIYSTDYYRVGGhTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWFQLSNTEVIECITQG 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6678617  487 YRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05049 241 RLLQRPRTCPSEVYAVMLGCWKREPQQRLNIKDIHKRL 278
SH2_Src_Fgr cd10367
Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene ...
152-250 2.12e-63

Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr; Fgr is a member of the Src non-receptor type tyrosine kinase family of proteins. The protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. Fgr is expressed in B-cells and myeloid cells, localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified Fgr has been shown to interact with Wiskott-Aldrich syndrome protein. Fgr has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198230  Cd Length: 101  Bit Score: 202.44  E-value: 2.12e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10367   1 QAEEWYFGKIGRKDAERQLLSPGNPRGAFLIRESETTKGAYSLSIRDWDQNRGDHVKHYKIRKLDTGGYYITTRAQFDTV 80
                        90
                ....*....|....*....
gi 6678617  232 QKLVKHYTEHADGLCHKLT 250
Cdd:cd10367  81 QELVQHYMEVNDGLCYLLT 99
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
268-526 1.23e-62

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 207.13  E-value: 1.23e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVVSE 339
Cdd:cd05061   1 WEVSREKITLLRELGQGSFGMVYEGNARDIikgeaeTRVAVKTVNESASLREriEFLNEASVMKGFTCHHVVRLLGVVSK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 -EPIYIVTEFMSKGSLLDFLK-------EGDGKYL-KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd05061  81 gQPTLVVMELMAHGDLKSYLRslrpeaeNNPGRPPpTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEYTaRQGAK--FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYR 488
Cdd:cd05061 161 GDFGMTRDIYETDYY-RKGGKglLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGY 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6678617  489 MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05061 240 LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 277
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
274-525 1.56e-62

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 206.74  E-value: 1.56e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGT------WNGTTKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYI 344
Cdd:cd05045   1 NLVLGKTLGEGEFGKVVKATafrlkgRAGYTTVAVKMLKENASSSElrDLLSEFNLLKQVNHPHVIKLYgACSQDGPLLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEG----------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV 402
Cdd:cd05045  81 IVEYAKYGSLRSFLRESrkvgpsylgsdgnrnssyldnpDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  403 GENLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLE 481
Cdd:cd05045 161 AEGRKMKISDFGLSRdVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6678617  482 QVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05045 241 LLKTGYRMERPENCSEEMYNLMLTCWKQEPDKRPTFADISKELE 284
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
280-518 1.69e-62

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 205.46  E-value: 1.69e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM--MPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLL 355
Cdd:smart00220   6 KLGEGSFGKVYLARDKKTgKLVAIKVIKKKKIkkDRERILREIKILKKLKHPNIVRLYDVfEDEDKLYLVMEYCEGGDLF 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     356 DFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-YTARQGAKFpi 434
Cdd:smart00220  86 DLLKKR--GRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGEkLTTFVGTPE-- 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     435 kWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVN-REVLEQVERGYR--MPCPQGCPESLHELMNLCWKKDP 511
Cdd:smart00220 162 -YMAPEVLLGKGYGKAVDIWSLGVILYELLT-GKPPFPGDDQlLELFKKIGKPKPpfPPPEWDISPEAKDLIRKLLVKDP 239

                   ....*..
gi 6678617     512 DERPTFE 518
Cdd:smart00220 240 EKRLTAE 246
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
280-528 1.39e-59

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 197.88  E-value: 1.39e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWN---GTTKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGS 353
Cdd:cd05116   2 ELGSGNFGTVKKGYYQmkkVVKTVAVKILKNEANDPalkDELLREANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYTARQGAK 431
Cdd:cd05116  82 LNKFLQKN--RHVTEKNITELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALraDENYYKAQTHGK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 511
Cdd:cd05116 160 WPVKWYAPECMNYYKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVTQMIEKGERMECPAGCPPEMYDLMKLCWTYDV 239
                       250
                ....*....|....*..
gi 6678617  512 DERPTFEYIQSFLEDYF 528
Cdd:cd05116 240 DERPGFAAVELRLRNYY 256
SH2_Src_Fyn_isoform_a_like cd10418
Src homology 2 (SH2) domain found in Fyn isoform a like proteins; Fyn is a member of the Src ...
152-249 1.91e-59

Src homology 2 (SH2) domain found in Fyn isoform a like proteins; Fyn is a member of the Src non-receptor type tyrosine kinase family of proteins. This cd contains the SH2 domain found in Fyn isoform a type proteins. Fyn is involved in the control of cell growth and is required in the following pathways: T and B cell receptor signaling, integrin-mediated signaling, growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation of natural killer cells, oligodendrocytes and keratinocytes. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the Fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules. FYN has been shown to interact with a number of proteins including: BCAR1, Cbl, Janus kinase, nephrin, Sky, tyrosine kinase, Wiskott-Aldrich syndrome protein, and Zap-70. Fyn has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198281  Cd Length: 101  Bit Score: 192.14  E-value: 1.91e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10418   1 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETL 80
                        90
                ....*....|....*...
gi 6678617  232 QKLVKHYTEHADGLCHKL 249
Cdd:cd10418  81 QQLVQHYSERAAGLCCRL 98
SH2_Src_Fyn cd10368
Src homology 2 (SH2) domain found in Fyn; Fyn is a member of the Src non-receptor type ...
152-252 2.29e-59

Src homology 2 (SH2) domain found in Fyn; Fyn is a member of the Src non-receptor type tyrosine kinase family of proteins. Fyn is involved in the control of cell growth and is required in the following pathways: T and B cell receptor signaling, integrin-mediated signaling, growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation of natural killer cells, oligodendrocytes and keratinocytes. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the Fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules. FYN has been shown to interact with a number of proteins including: BCAR1, Cbl, Janus kinase, nephrin, Sky, tyrosine kinase, Wiskott-Aldrich syndrome protein, and Zap-70. Fyn has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198231 [Multi-domain]  Cd Length: 101  Bit Score: 191.78  E-value: 2.29e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10368   1 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETL 80
                        90       100
                ....*....|....*....|.
gi 6678617  232 QKLVKHYTEHADGLCHKLTTV 252
Cdd:cd10368  81 QQLVQHYSETANGLCKVLIVT 101
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
270-525 2.48e-58

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 195.57  E-value: 2.48e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTW------NGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSE-EP 341
Cdd:cd05092   2 IKRRDIVLKWELGEGAFGKVFLAEChnllpeQDKMLVAVKALKEATESArQDFQREAELLTVLQHQHIVRFYGVCTEgEP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLK----------EGDGK---YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLIC 408
Cdd:cd05092  82 LIMVFEYMRHGDLNRFLRshgpdakildGGEGQapgQLTLGQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGQGLVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  409 KIADFGLARLIEDNEYTaRQGAK--FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERG 486
Cdd:cd05092 162 KIGDFGMSRDIYSTDYY-RVGGRtmLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQG 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  487 YRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05092 241 RELERPRTCPPEVYAIMQGCWQREPQQRHSIKDIHSRLQ 279
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
272-528 4.16e-58

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 194.39  E-value: 4.16e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRL-EVKLGQGCFGEVWMGTWNGTTK---VAIKTLKPGT--MMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIV 345
Cdd:cd05115   2 RDNLLIdEVELGSGNFGCVKKGVYKMRKKqidVAIKVLKQGNekAVRDEMMREAQIMHQLDNPYIVRMIGVCEAEALMLV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKeGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNE 423
Cdd:cd05115  82 MEMASGGPLNKFLS-GKKDEITVSNVVELMHQVSMGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALgaDDSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELM 503
Cdd:cd05115 161 YKARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVMSFIEQGKRMDCPAECPPEMYALM 240
                       250       260
                ....*....|....*....|....*
gi 6678617  504 NLCWKKDPDERPTFEYIQSFLEDYF 528
Cdd:cd05115 241 SDCWIYKWEDRPNFLTVEQRMRTYY 265
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
281-524 1.86e-57

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 190.94  E-value: 1.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLKPG--TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLD 356
Cdd:cd00180   1 LGKGSFGKVYKARDKETgKKVAVKVIPKEklKKLLEELLREIEILKKLNHPNIVKLYDVFETENfLYLVMEYCEGGSLKD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF-PIK 435
Cdd:cd00180  81 LLKENKGP-LSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGTtPPY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 WTAPEAALYGRFTIKSDVWSFGIlqtelvtkgrvpypgmvnreVLeqvergYRMPcpqgcpeSLHELMNLCWKKDPDERP 515
Cdd:cd00180 160 YAPPELLGGRYYGPKVDIWSLGV--------------------IL------YELE-------ELKDLIRRMLQYDPKKRP 206

                ....*....
gi 6678617  516 TFEYIQSFL 524
Cdd:cd00180 207 SAKELLEHL 215
PTKc_IGF-1R cd05062
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs ...
268-526 7.49e-57

Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. IGF-1R is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the ligand (IGF-1 or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, which stimulates downstream kinase activities and biological function. IGF-1R signaling is important in the differentiation, growth, and survival of normal cells. In cancer cells, where it is frequently overexpressed, IGF-1R is implicated in proliferation, the suppression of apoptosis, invasion, and metastasis. IGF-1R is being developed as a therapeutic target in cancer treatment. The IGF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133193 [Multi-domain]  Cd Length: 277  Bit Score: 191.40  E-value: 7.49e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVVSE 339
Cdd:cd05062   1 WEVAREKITMSRELGQGSFGMVYEGIAKGVvkdepeTRVAIKTVNEAASMREriEFLNEASVMKEFNCHHVVRLLGVVSQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 -EPIYIVTEFMSKGSLLDFL-----KEGDGKYLKLPQL---VDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd05062  81 gQPTLVIMELMTRGDLKSYLrslrpEMENNPVQAPPSLkkmIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEYTaRQGAK--FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYR 488
Cdd:cd05062 161 GDFGMTRDIYETDYY-RKGGKglLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGL 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6678617  489 MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05062 240 LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 277
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
270-526 8.38e-57

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 191.14  E-value: 8.38e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTWNGT------TKVAIKTL--KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-E 340
Cdd:cd05046   2 FPRSNLQEITTLGRGEFGEVFLAKAKGIeeeggeTLVLVKALqkTKDENLQSEFRRELDMFRKLSHKNVVRLLGLCREaE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKGSLLDFL---KEGDGKY----LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADF 413
Cdd:cd05046  82 PHYMILEYTDLGDLKQFLratKSKDEKLkpppLSTKQKVALCTQIALGMDHLSNARFVHRDLAARNCLVSSQREVKVSLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  414 GLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERG-YRMPCP 492
Cdd:cd05046 162 SLSKDVYNSEYYKLRNALIPLRWLAPEAVQEDDFSTKSDVWSFGVLMWEVFTQGELPFYGLSDEEVLNRLQAGkLELPVP 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  493 QGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05046 242 EGCPSRLYKLMTRCWAVNPKDRPSFSELVSALGE 275
SH2_Src_Src cd10365
Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src); Src is a member of the Src ...
152-252 1.40e-56

Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src); Src is a member of the Src non-receptor type tyrosine kinase family of proteins. Src is thought to play a role in the regulation of embryonic development and cell growth. Members here include v-Src and c-Src. v-Src lacks the C-terminal inhibitory phosphorylation site and is therefore constitutively active as opposed to normal cellular src (c-Src) which is only activated under certain circumstances where it is required (e.g. growth factor signaling). v-Src is an oncogene whereas c-Src is a proto-oncogene. c-Src consists of three domains, an N-terminal SH3 domain, a central SH2 domain and a tyrosine kinase domain. The SH2 and SH3 domains work together in the auto-inhibition of the kinase domain. The phosphorylation of an inhibitory tyrosine near the c-terminus of the protein produces a binding site for the SH2 domain which then facilitates binding of the SH3 domain to a polyproline site within the linker between the SH2 domain and the kinase domain. Binding of the SH3 domain inactivates the enzyme. This allows for multiple mechanisms for c-Src activation: dephosphorylation of the C-terminal tyrosine by a protein tyrosine phosphatase, binding of the SH2 domain by a competitive phospho-tyrosine residue, or competitive binding of a polyproline binding site to the SH3 domain. Unlike most other Src members Src lacks cysteine residues in the SH4 domain that undergo palmitylation. Serine and threonine phosphorylation sites have also been identified in the unique domains of Src and are believed to modulate protein-protein interactions or regulate catalytic activity. Alternatively spliced forms of Src, which contain 6- or 11-amino acid insertions in the SH3 domain, are expressed in CNS neurons. c-Src has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198228  Cd Length: 101  Bit Score: 184.48  E-value: 1.40e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10365   1 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSL 80
                        90       100
                ....*....|....*....|.
gi 6678617  232 QKLVKHYTEHADGLCHKLTTV 252
Cdd:cd10365  81 QQLVAYYSKHADGLCHRLTTV 101
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
269-527 3.90e-56

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 189.84  E-value: 3.90e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMG-----TWNGTTKVAIKTLK--PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE- 340
Cdd:cd05090   1 ELPLSAVRFMEELGECAFGKIYKGhlylpGMDHAQLVAIKTLKdyNNPQQWNEFQQEASLMTELHHPNIVCLLGVVTQEq 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKGSLLDFL------------KEGDGKY---LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN 405
Cdd:cd05090  81 PVCMLFEFMNQGDLHEFLimrsphsdvgcsSDEDGTVkssLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  406 LICKIADFGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE 484
Cdd:cd05090 161 LHVKISDLGLSREIYSSDYYRVQNKSLlPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVR 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6678617  485 RGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05090 241 KRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDIHARLRSW 283
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
268-534 6.17e-56

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 189.84  E-value: 6.17e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTKVAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAV 336
Cdd:cd05098   8 WELPRDRLVLGKPLGEGCFGQVVLAEAigldkdkpNRVTKVAVKMLKSDATEKDLsdLISEMEMMKMIgKHKNIINLLGA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEE-PIYIVTEFMSKGSLLDFLK--------------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL 401
Cdd:cd05098  88 CTQDgPLYVIVEYASKGNLREYLQarrppgmeycynpsHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  402 VGENLICKIADFGLARLIEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVL 480
Cdd:cd05098 168 VTEDNVMKIADFGLARDIHHIDYYKKTtNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  481 EQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQ 534
Cdd:cd05098 248 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 301
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
281-530 6.99e-56

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 188.45  E-value: 6.99e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT----TKVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVV--SEEPIYIVTEFMSKG 352
Cdd:cd05058   3 IGKGHFGCVYHGTLIDSdgqkIHCAVKSLNRITDIEEveQFLKEGIIMKDFSHPNVLSLLGIClpSEGSPLVVLPYMKHG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFL-KEGDGKYLKlpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ--- 428
Cdd:cd05058  83 DLRNFIrSETHNPTVK--DLIGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARDIYDKEYYSVHnht 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd05058 161 GAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDSFDITVYLLQGRRLLQPEYCPDPLYEVMLSCWH 240
                       250       260
                ....*....|....*....|..
gi 6678617  509 KDPDERPTFEYIQSFLEDYFTA 530
Cdd:cd05058 241 PKPEMRPTFSELVSRISQIFST 262
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
268-517 1.19e-55

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 188.85  E-value: 1.19e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVV- 337
Cdd:cd05054   2 WEFPRDRLKLGKPLGRGAFGKVIQASAFGIDKsatcrtVAVKMLKEGATASEhkALMTELKILIHIgHHLNVVNLLGACt 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  338 -SEEPIYIVTEFMSKGSLLDFLK---------------------EGDGKY---LKLPQLVDMAAQIADGMAYIERMNYIH 392
Cdd:cd05054  82 kPGGPLMVIVEFCKFGNLSNYLRskreefvpyrdkgardveeeeDDDELYkepLTLEDLICYSFQVARGMEFLASRKCIH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  393 RDLRAANILVGENLICKIADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPY 471
Cdd:cd05054 162 RDLAARNILLSENNVVKICDFGLARDIyKDPDYVRKGDARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  472 PGM-VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTF 517
Cdd:cd05054 242 PGVqMDEEFCRRLKEGTRMRAPEYTTPEIYQIMLDCWHGEPKERPTF 288
PTKc_CSF-1R cd05106
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs ...
260-525 2.62e-55

Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. CSF-1R, also called c-Fms, is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of CSF-1R to its ligand, CSF-1, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. It leads to increases in gene transcription and protein translation, and induces cytoskeletal remodeling. CSF-1R signaling leads to a variety of cellular responses including survival, proliferation, and differentiation of target cells. It plays an important role in innate immunity, tissue development and function, and the pathogenesis of some diseases including atherosclerosis and cancer. CSF-1R signaling is also implicated in mammary gland development during pregnancy and lactation. Aberrant CSF-1/CSF-1R expression correlates with tumor cell invasiveness, poor clinical prognosis, and bone metastasis in breast cancer. Although the structure of the human CSF-1R catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. The CSF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133237 [Multi-domain]  Cd Length: 374  Bit Score: 190.44  E-value: 2.62e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  260 TQGLAKDAWEIPRESLRLEVKLGQGCFGEV------WMGTWNGTTKVAIKTLKPG--TMMPEAFLQEAQIMKKL-RHDKL 330
Cdd:cd05106  25 TQLPYNEKWEFPRDNLQFGKTLGAGAFGKVveatafGLGKEDNVLRVAVKMLKASahTDEREALMSELKILSHLgQHKNI 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  331 VPLY-AVVSEEPIYIVTEFMSKGSLLDFLK-----------------EGDGKY--------------------------- 365
Cdd:cd05106 105 VNLLgACTHGGPVLVITEYCCYGDLLNFLRkkaetflnfvmalpeisETSSDYknitlekkyirsdsgfssqgsdtyvem 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  366 ------------------------LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE- 420
Cdd:cd05106 185 rpvsssssqssdskdeedtedswpLDLDDLLRFSSQVAQGMDFLASKNCIHRDVAARNVLLTDGRVAKICDFGLARDIMn 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05106 265 DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPGIlVNSKFYKMVKRGYQMSRPDFAPPEI 344
                       330       340
                ....*....|....*....|....*.
gi 6678617  500 HELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05106 345 YSIMKMCWNLEPTERPTFSQISQLIQ 370
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
276-516 9.79e-55

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 185.10  E-value: 9.79e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFM 349
Cdd:cd14014   3 RLVRLLGRGGMGEVYRARDTLLgRPVAIKVLRPELAEDEEfrerFLREARALARLSHPNIVRVYDVGEDDgRPYIVMEYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:cd14014  83 EGGSLADLLRER--GPLPPREALRILAQIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALGDSGLTQTGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQ---GCPESLHELMNLC 506
Cdd:cd14014 161 VLGTPAYMAPEQARGGPVDPRSDIYSLGVVLYELLT-GRPPFDGDSPAAVLAKHLQEAPPPPSPlnpDVPPALDAIILRA 239
                       250
                ....*....|
gi 6678617  507 WKKDPDERPT 516
Cdd:cd14014 240 LAKDPEERPQ 249
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
269-526 2.43e-54

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 185.58  E-value: 2.43e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK-----------------VAIKTLKP--GTMMPEAFLQEAQIMKKLRHDK 329
Cdd:cd05095   1 EFPRKLLTFKEKLGEGQFGEVHLCEAEGMEKfmdkdfalevsenqpvlVAVKMLRAdaNKNARNDFLKEIKIMSRLKDPN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  330 LVPLYAV-VSEEPIYIVTEFMSKGSLLDFL--KEGDGKYLKLP--------QLVDMAAQIADGMAYIERMNYIHRDLRAA 398
Cdd:cd05095  81 IIRLLAVcITDDPLCMITEYMENGDLNQFLsrQQPEGQLALPSnaltvsysDLRFMAAQIASGMKYLSSLNFVHRDLATR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  399 NILVGENLICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR-VPYPGMVN 476
Cdd:cd05095 161 NCLVGKNYTIKIADFGMSRNLYSGDYYRIQGrAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETLTFCReQPYSQLSD 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  477 REVLEQVERGYR-------MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05095 241 EQVIENTGEFFRdqgrqtyLPQPALCPDSVYKLMLSCWRRDTKDRPSFQEIHTLLQE 297
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
269-524 2.90e-54

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 185.18  E-value: 2.90e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK---------------VAIKTLKP--GTMMPEAFLQEAQIMKKLRHDKLV 331
Cdd:cd05097   1 EFPRQQLRLKEKLGEGQFGEVHLCEAEGLAEflgegapefdgqpvlVAVKMLRAdvTKTARNDFLKEIKIMSRLKNPNII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  332 PLYAV-VSEEPIYIVTEFMSKGSLLDFL--KEGDGKYLK---LP-----QLVDMAAQIADGMAYIERMNYIHRDLRAANI 400
Cdd:cd05097  81 RLLGVcVSDDPLCMITEYMENGDLNQFLsqREIESTFTHannIPsvsiaNLLYMAVQIASGMKYLASLNFVHRDLATRNC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  401 LVGENLICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR-VPYPGMVNRE 478
Cdd:cd05097 161 LVGNHYTIKIADFGMSRNLYSGDYYRIQGrAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEMFTLCKeQPYSLLSDEQ 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617  479 VLEQVERGYR-------MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05097 241 VIENTGEFFRnqgrqiyLSQTPLCPSPVFKLMMRCWSRDIKDRPTFNKIHHFL 293
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
281-525 3.57e-54

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 184.44  E-value: 3.57e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWN---GTTKVAIKTLKPG----TMMpEAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIY----IVT 346
Cdd:cd05075   8 LGEGEFGSVMEGQLNqddSVLKVAVKTMKIAictrSEM-EDFLSEAVCMKEFDHPNVMRLIGVClqnTESEGYpspvVIL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFL---KEGDGK-YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd05075  87 PFMKHGDLHSFLlysRLGDCPvYLPTQMLVKFMTDIASGMEYLSSKNFIHRDLAARNCMLNENMNVCVADFGLSKKIYNG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTaRQG--AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLH 500
Cdd:cd05075 167 DYY-RQGriSKMPVKWIAIESLADRVYTTKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPPDCLDGLY 245
                       250       260
                ....*....|....*....|....*
gi 6678617  501 ELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05075 246 ELMSSCWLLNPKDRPSFETLRCELE 270
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
268-531 3.66e-54

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 185.60  E-value: 3.66e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK--------VAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAV 336
Cdd:cd05101  19 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKdkpkeavtVAVKMLKDDATEKDLsdLVSEMEMMKMIgKHKNIINLLGA 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEE-PIYIVTEFMSKGSLLDFLK-----EGDGKY---------LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL 401
Cdd:cd05101  99 CTQDgPLYVIVEYASKGNLREYLRarrppGMEYSYdinrvpeeqMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  402 VGENLICKIADFGLARLIEDNEYTAR-QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVL 480
Cdd:cd05101 179 VTENNVMKIADFGLARDINNIDYYKKtTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 258
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  481 EQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTAT 531
Cdd:cd05101 259 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 309
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
281-518 5.49e-53

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 181.38  E-value: 5.49e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-----NGTTKVAIKTLKPGTMmPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKG 352
Cdd:cd05109  15 LGSGAFGTVYKGIWipdgeNVKIPVAIKVLRENTS-PKAnkeILDEAYVMAGVGSPYVCRLLGICLTSTVQLVTQLMPYG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTArQGA 430
Cdd:cd05109  94 CLLDYVRENKDR-IGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLldIDETEYHA-DGG 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 510
Cdd:cd05109 172 KVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMID 251

                ....*...
gi 6678617  511 PDERPTFE 518
Cdd:cd05109 252 SECRPRFR 259
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
269-527 6.84e-53

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 181.37  E-value: 6.84e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVS-E 339
Cdd:cd05091   2 EINLSAVRFMEELGEDRFGKVYKGHLFGTAPgeqtqaVAIKTLKDKAEGPlrEEFRHEAMLRSRLQHPNIVCLLGVVTkE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 EPIYIVTEFMSKGSLLDFL----------KEGDGKYLKL----PQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN 405
Cdd:cd05091  82 QPMSMIFSYCSHGDLHEFLvmrsphsdvgSTDDDKTVKStlepADFLHIVTQIAAGMEYLSSHHVVHKDLATRNVLVFDK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  406 LICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE 484
Cdd:cd05091 162 LNVKISDLGLFREVYAADYYKLMGNSlLPIRWMSPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVIEMIR 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6678617  485 RGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05091 242 NRQVLPCPDDCPAWVYTLMLECWNEFPSRRPRFKDIHSRLRTW 284
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
264-538 1.38e-52

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 182.14  E-value: 1.38e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  264 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK--------VAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVP 332
Cdd:cd05100   3 ADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKdkpnkpvtVAVKMLKDDATDKDLsdLVSEMEMMKMIgKHKNIIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  333 LYAVVSEE-PIYIVTEFMSKGSLLDFLK-------EGDGKYLKLPQ-------LVDMAAQIADGMAYIERMNYIHRDLRA 397
Cdd:cd05100  83 LLGACTQDgPLYVLVEYASKGNLREYLRarrppgmDYSFDTCKLPEeqltfkdLVSCAYQVARGMEYLASQKCIHRDLAA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  398 ANILVGENLICKIADFGLARLIEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVN 476
Cdd:cd05100 163 RNVLVTEDNVMKIADFGLARDVHNIDYYKKTtNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV 242
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  477 REVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEP-----------QYQPG 538
Cdd:cd05100 243 EELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTdeyldlsvpfeQYSPG 315
PTKc_DDR1 cd05096
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze ...
269-524 1.96e-52

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133227 [Multi-domain]  Cd Length: 304  Bit Score: 180.52  E-value: 1.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTK-----------------VAIKTLKPGTM--MPEAFLQEAQIMKKLRHDK 329
Cdd:cd05096   1 KFPRGHLLFKEKLGEGQFGEVHLCEVVNPQDlptlqfpfnvrkgrpllVAVKILRPDANknARNDFLKEVKILSRLKDPN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  330 LVPLYAV-VSEEPIYIVTEFMSKGSLLDFL-------KEGDGKY----------LKLPQLVDMAAQIADGMAYIERMNYI 391
Cdd:cd05096  81 IIRLLGVcVDEDPLCMITEYMENGDLNQFLsshhlddKEENGNDavppahclpaISYSSLLHVALQIASGMKYLSSLNFV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRV- 469
Cdd:cd05096 161 HRDLATRNCLVGENLTIKIADFGMSRNLYAGDYYRIQGrAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLCKEq 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6678617  470 PYPGMVNREVLEQVERGYR-------MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd05096 241 PYGELTDEQVIENAGEFFRdqgrqvyLFRPPPCPQGLYELMLQCWSRDCRERPSFSDIHAFL 302
SH2_Src_Fyn_isoform_b_like cd10419
Src homology 2 (SH2) domain found in Fyn isoform b like proteins; Fyn is a member of the Src ...
153-252 2.06e-52

Src homology 2 (SH2) domain found in Fyn isoform b like proteins; Fyn is a member of the Src non-receptor type tyrosine kinase family of proteins. This cd contains the SH2 domain found in Fyn isoform b type proteins. Fyn is involved in the control of cell growth and is required in the following pathways: T and B cell receptor signaling, integrin-mediated signaling, growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation of natural killer cells, oligodendrocytes and keratinocytes. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the Fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules. FYN has been shown to interact with a number of proteins including: BCAR1, Cbl, Janus kinase, nephrin, Sky, tyrosine kinase, Wiskott-Aldrich syndrome protein, and Zap-70. Fyn has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198282  Cd Length: 101  Bit Score: 173.71  E-value: 2.06e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  153 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQ 232
Cdd:cd10419   2 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQ 81
                        90       100
                ....*....|....*....|
gi 6678617  233 KLVKHYTEHADGLCHKLTTV 252
Cdd:cd10419  82 QLVQHYSEKADGLCFNLTVI 101
PTKc_Mer cd14204
Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the ...
270-525 4.15e-52

Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Mer (or Mertk) is named after its original reported expression pattern (monocytes, epithelial, and reproductive tissues). It is required for the ingestion of apoptotic cells by phagocytes such as macrophages, retinal pigment epithelial cells, and dendritic cells. Mer is also important in maintaining immune homeostasis. Mer is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Mer subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271106 [Multi-domain]  Cd Length: 284  Bit Score: 178.97  E-value: 4.15e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTW---NGTT-KVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSE--- 339
Cdd:cd14204   4 IDRNLLSLGKVLGEGEFGSVMEGELqqpDGTNhKVAVKTMKLDNFSQreiEEFLSEAACMKDFNHPNVIRLLGVCLEvgs 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 ----EPIyIVTEFMSKGSLLDFL----KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIA 411
Cdd:cd14204  84 qripKPM-VILPFMKYGDLHSFLlrsrLGSGPQHVPLQTLLKFMIDIALGMEYLSSRNFLHRDLAARNCMLRDDMTVCVA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARLIEDNEYTaRQG--AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRM 489
Cdd:cd14204 163 DFGLSKKIYSGDYY-RQGriAKMPVKWIAVESLADRVYTVKSDVWAFGVTMWEIATRGMTPYPGVQNHEIYDYLLHGHRL 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6678617  490 PCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14204 242 KQPEDCLDELYDIMYSCWRSDPTDRPTFTQLRENLE 277
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
281-526 1.13e-51

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 177.73  E-value: 1.13e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNG----TTKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSE--------EPIyIV 345
Cdd:cd05035   7 LGEGEFGSVMEAQLKQddgsQLKVAVKTMKVDIHTYseiEEFLSEAACMKDFDHPNVMRLIGVCFTasdlnkppSPM-VI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFL----KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd05035  86 LPFMKHGDLHSYLlysrLGGLPEKLPLQTLLKFMVDIAKGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSRKIYS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTaRQG--AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05035 166 GDYY-RQGriSKMPVKWIALESLADNVYTSKSDVWSFGVTMWEIATRGQTPYPGVENHEIYDYLRNGNRLKQPEDCLDEV 244
                       250       260
                ....*....|....*....|....*..
gi 6678617  500 HELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd05035 245 YFLMYFCWTVDPKDRPTFTKLREVLEN 271
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
270-535 6.35e-51

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 176.00  E-value: 6.35e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPEA-FLQEAQIMKKLRHDKLVPLYAV-VSEEP 341
Cdd:cd05093   2 IKRHNIVLKRELGEGAFGKVFLAECYNLCPeqdkilVAVKTLKDASDNARKdFHREAELLTNLQHEHIVKFYGVcVEGDP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKE--------GDGK---YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd05093  82 LIMVFEYMKHGDLNKFLRAhgpdavlmAEGNrpaELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRM 489
Cdd:cd05093 162 GDFGMSRDVYSTDYYRVGGhTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  490 PCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATePQY 535
Cdd:cd05093 242 QRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQNLAKAS-PVY 286
PTKc_Tyro3 cd05074
Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the ...
270-525 2.05e-50

Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyro3 (or Sky) is predominantly expressed in the central nervous system and the brain, and functions as a neurotrophic factor. It is also expressed in osteoclasts and has a role in bone resorption. Tyro3 is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Tyro3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270659 [Multi-domain]  Cd Length: 284  Bit Score: 174.72  E-value: 2.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFG---EVWMGTWNGT-TKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSEE-- 340
Cdd:cd05074   6 IQEQQFTLGRMLGKGEFGsvrEAQLKSEDGSfQKVAVKMLKADIFSSsdiEEFLREAACMKEFDHPNVIKLIGVSLRSra 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 ----PI-YIVTEFMSKGSLLDFL---KEGDGKY-LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIA 411
Cdd:cd05074  86 kgrlPIpMVILPFMKHGDLHTFLlmsRIGEEPFtLPLQTLVRFMIDIASGMEYLSSKNFIHRDLAARNCMLNENMTVCVA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARLIEDNEYTaRQG--AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRM 489
Cdd:cd05074 166 DFGLSKKIYSGDYY-RQGcaSKLPVKWLALESLADNVYTTHSDVWAFGVTMWEIMTRGQTPYAGVENSEIYNYLIKGNRL 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6678617  490 PCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05074 245 KQPPDCLEDVYELMCQCWSPEPKCRPSFQHLRDQLE 280
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
270-530 4.92e-50

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 173.41  E-value: 4.92e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGTWN----GTTKVAIKTLKPG------TMMpeafLQEAQIMKKLRHDKLVPLYAVVSE 339
Cdd:cd05043   3 VSRERVTLSDLLQEGTFGRIFHGILRdekgKEEEVLVKTVKDHaseiqvTML----LQESSLLYGLSHQNLLPILHVCIE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 --EPIYIVTEFMSKGSLLDFLK------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIA 411
Cdd:cd05043  79 dgEKPMVLYPYMNWGNLKLFLQqcrlseANNPQALSTQQLVHMALQIACGMSYLHRRGVIHKDIAARNCVIDDELQVKIT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLAR--------LIEDNEYTarqgakfPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV 483
Cdd:cd05043 159 DNALSRdlfpmdyhCLGDNENR-------PIKWMSLESLVNKEYSSASDVWSFGVLLWELMTLGQTPYVEIDPFEMAAYL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  484 ERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTA 530
Cdd:cd05043 232 KDGYRLAQPINCPDELFAVMACCWALDPEERPSFQQLVQCLTDFHAQ 278
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
281-520 5.90e-49

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 170.22  E-value: 5.90e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVW--MGTWNGT-TKVAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAVVSEEP-IYIVTEFMSKGS 353
Cdd:cd05047   3 IGEGNFGQVLkaRIKKDGLrMDAAIKRMKEYASKDDHrdFAGELEVLCKLgHHPNIINLLGACEHRGyLYLAIEYAPHGN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKE--------------GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI 419
Cdd:cd05047  83 LLDFLRKsrvletdpafaianSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EdnEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05047 163 E--VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEV 240
                       250       260
                ....*....|....*....|.
gi 6678617  500 HELMNLCWKKDPDERPTFEYI 520
Cdd:cd05047 241 YDLMRQCWREKPYERPSFAQI 261
PTKc_TrkC cd05094
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze ...
270-531 6.71e-49

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkC is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkC to its ligand, neurotrophin 3 (NT3), results in receptor oligomerization and activation of the catalytic domain. TrkC is broadly expressed in the nervous system and in some non-neural tissues including the developing heart. NT3/TrkC signaling plays an important role in the innervation of the cardiac conducting system and the development of smooth muscle cells. Mice deficient with NT3 and TrkC have multiple heart defects. NT3/TrkC signaling is also critical for the development and maintenance of enteric neurons that are important for the control of gut peristalsis. The TrkC subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270676 [Multi-domain]  Cd Length: 287  Bit Score: 170.58  E-value: 6.71e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  270 IPRESLRLEVKLGQGCFGEVWMGT-WN-GTTK----VAIKTLK-PGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEP 341
Cdd:cd05094   2 IKRRDIVLKRELGEGAFGKVFLAEcYNlSPTKdkmlVAVKTLKdPTLAARKDFQREAELLTNLQHDHIVKFYGVcGDGDP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKEG--------DGKYLK------LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLI 407
Cdd:cd05094  82 LIMVFEYMKHGDLNKFLRAHgpdamilvDGQPRQakgelgLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGANLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  408 CKIADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERG 486
Cdd:cd05094 162 VKIGDFGMSRDVYSTDYYRVGGhTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQG 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6678617  487 YRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTAT 531
Cdd:cd05094 242 RVLERPRVCPKEVYDIMLGCWQREPQQRLNIKEIYKILHALGKAT 286
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
281-534 2.00e-48

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 170.20  E-value: 2.00e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-----VAIKTLKPGTMmPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKG 352
Cdd:cd05108  15 LGSGAFGTVYKGLWIPEGEkvkipVAIKELREATS-PKAnkeILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYTArQGA 430
Cdd:cd05108  94 CLLDYVREHKDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLgaEEKEYHA-EGG 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 510
Cdd:cd05108 172 KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID 251
                       250       260
                ....*....|....*....|....*
gi 6678617  511 PDERPTF-EYIQSFLEdyfTATEPQ 534
Cdd:cd05108 252 ADSRPKFrELIIEFSK---MARDPQ 273
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
281-523 2.20e-48

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 169.34  E-value: 2.20e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-----NGTTKVAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMS 350
Cdd:cd05079  12 LGEGHFGKVELCRYdpegdNTGEQVAVKSLKPESGGNHIadLKKEIEILRNLYHENIVKYKGICTEDGgngIKLIMEFLP 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE--YTARQ 428
Cdd:cd05079  92 SGSLKEYLPRNKNK-INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKeyYTVKD 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT-------------KGRVPYPG-MVNREVLEQVERGYRMPCPQG 494
Cdd:cd05079 171 DLDSPVFWYAPECLIQSKFYIASDVWSFGVTLYELLTycdsesspmtlflKMIGPTHGqMTVTRLVRVLEEGKRLPRPPN 250
                       250       260       270
                ....*....|....*....|....*....|
gi 6678617  495 CPESLHELMNLCWKKDPDERPTFE-YIQSF 523
Cdd:cd05079 251 CPEEVYQLMRKCWEFQPSKRTTFQnLIEGF 280
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
273-520 2.69e-48

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 169.41  E-value: 2.69e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEV--WMGTWNGTT-KVAIKTLKPGTMMPEA--FLQEAQIMKKL-RHDKLVPLYAVVSEEP-IYIV 345
Cdd:cd05089   2 EDIKFEDVIGEGNFGQVikAMIKKDGLKmNAAIKMLKEFASENDHrdFAGELEVLCKLgHHPNIINLLGACENRGyLYIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKE--------------GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIA 411
Cdd:cd05089  82 IEYAPYGNLLDFLRKsrvletdpafakehGTASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARliEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPC 491
Cdd:cd05089 162 DFGLSR--GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEK 239
                       250       260
                ....*....|....*....|....*....
gi 6678617  492 PQGCPESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd05089 240 PRNCDDEVYELMRQCWRDRPYERPPFSQI 268
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
281-534 4.20e-48

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 169.09  E-value: 4.20e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW--NGTT---KVAIKTLKPgTMMPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKG 352
Cdd:cd05110  15 LGSGAFGTVYKGIWvpEGETvkiPVAIKILNE-TTGPKAnveFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFL---KEGDGKYLklpqLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE--DNEYTAr 427
Cdd:cd05110  94 CLLDYVhehKDNIGSQL----LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEgdEKEYNA- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 507
Cdd:cd05110 169 DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW 248
                       250       260
                ....*....|....*....|....*..
gi 6678617  508 KKDPDERPTFEYIQSflEDYFTATEPQ 534
Cdd:cd05110 249 MIDADSRPKFKELAA--EFSRMARDPQ 273
SH2_Src_HCK cd10363
Src homology 2 (SH2) domain found in HCK; HCK is a member of the Src non-receptor type ...
152-253 9.28e-48

Src homology 2 (SH2) domain found in HCK; HCK is a member of the Src non-receptor type tyrosine kinase family of proteins and is expressed in hemopoietic cells. HCK is proposed to couple the Fc receptor to the activation of the respiratory burst. It may also play a role in neutrophil migration and in the degranulation of neutrophils. It has two different translational starts that have different subcellular localization. HCK has been shown to interact with BCR gene, ELMO1 Cbl gene, RAS p21 protein activator 1, RASA3, Granulocyte colony-stimulating factor receptor, ADAM15 and RAPGEF1. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its C-terminal tail. In general SH2 domains are involved in signal transduction. HCK has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198226  Cd Length: 104  Bit Score: 161.29  E-value: 9.28e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10363   1 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPQHGDTVKHYKIRTLDNGGFYISPRSTFSTL 80
                        90       100
                ....*....|....*....|..
gi 6678617  232 QKLVKHYTEHADGLCHKLTTVC 253
Cdd:cd10363  81 QELVDHYKKGNDGLCQKLSVPC 102
PTKc_Kit cd05104
Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the ...
268-525 4.84e-47

Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270682 [Multi-domain]  Cd Length: 375  Bit Score: 168.16  E-value: 4.84e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLY-AVV 337
Cdd:cd05104  30 WEFPRDRLRFGKTLGAGAFGKVVEATAYGLAKadsamtVAVKMLKPSAHSTEreALMSELKVLSYLgNHINIVNLLgACT 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  338 SEEPIYIVTEFMSKGSLLDFLK---------------------------------------------------------- 359
Cdd:cd05104 110 VGGPTLVITEYCCYGDLLNFLRrkrdsficpkfedlaeaalyrnllhqremacdslneymdmkpsvsyvvptkadkrrgv 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 ---------------EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNE 423
Cdd:cd05104 190 rsgsyvdqdvtseilEEDELALDTEDLLSFSYQVAKGMEFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRnDSN 269
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESLHEL 502
Cdd:cd05104 270 YVVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMpVDSKFYKMIKEGYRMDSPEFAPSEMYDI 349
                       330       340
                ....*....|....*....|...
gi 6678617  503 MNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05104 350 MRSCWDADPLKRPTFKQIVQLIE 372
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
267-529 5.85e-47

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 168.65  E-value: 5.85e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  267 AWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTKVAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVV 337
Cdd:cd05107  31 AWEMPRDNLVLGRTLGSGAFGRVVEATAHGlshsqsTMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNIVNLLGAC 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  338 SEE-PIYIVTEFMSKGSLLDFLK---------------------------------------EGDGKYLK---------- 367
Cdd:cd05107 111 TKGgPIYIITEYCRYGDLVDYLHrnkhtflqyyldknrddgslisggstplsqrkshvslgsESDGGYMDmskdesadyv 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  368 --------------------------LPQ---------------------LVDMAAQIADGMAYIERMNYIHRDLRAANI 400
Cdd:cd05107 191 pmqdmkgtvkyadiessnyespydqyLPSapertrrdtlinespalsymdLVGFSYQVANGMEFLASKNCVHRDLAARNV 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  401 LVGENLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNRE 478
Cdd:cd05107 271 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNEQ 350
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  479 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFT 529
Cdd:cd05107 351 FYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQLVHLVGDLLT 401
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
268-525 7.86e-47

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 168.28  E-value: 7.86e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTT------KVAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVVS 338
Cdd:cd05105  32 WEFPRDGLVLGRILGSGAFGKVVEGTAYGLSrsqpvmKVAVKMLKPTARSSEkqALMSELKIMTHLgPHLNIVNLLGACT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EE-PIYIVTEFMSKGSLLDFLK--------------------------------------EGDGKYLKLPQ--------- 370
Cdd:cd05105 112 KSgPIYIITEYCFYGDLVNYLHknrdnflsrhpekpkkdldifginpadestrsyvilsfENKGDYMDMKQadttqyvpm 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  371 -----------------------------------------------LVDMAAQIADGMAYIERMNYIHRDLRAANILVG 403
Cdd:cd05105 192 leikeaskysdiqrsnydrpasykgsndsevknllsddgseglttldLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  404 ENLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLE 481
Cdd:cd05105 272 QGKIVKICDFGLARdIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMiVDSTFYN 351
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 6678617  482 QVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05105 352 KIKSGYRMAKPDHATQEVYDIMVKCWNSEPEKRPSFLHLSDIVE 395
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
275-527 1.77e-46

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 163.92  E-value: 1.77e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGTTK-----VAIKTLKP--GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE---EPIYI 344
Cdd:cd05080   6 LKKIRDLGEGHFGKVSLYCYDPTNDgtgemVAVKALKAdcGPQHRSGWKQEIDILKTLYHENIVKYKGCCSEqggKSLQL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEGDgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE- 423
Cdd:cd05080  86 IMEYVPLGSLRDYLPKHS---IGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHe 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 -YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRV-------------PYPGMVNR-EVLEQVERGYR 488
Cdd:cd05080 163 yYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSsqspptkflemigIAQGQMTVvRLIELLERGER 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  489 MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDY 527
Cdd:cd05080 243 LPCPDKCPQEVYHLMKNCWETEASFRPTFENLIPILKTV 281
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
276-515 5.18e-46

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 168.27  E-value: 5.18e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPG-TMMPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFM 349
Cdd:COG0515  10 RILRLLGRGGMGVVYLARDLRLgRPVALKVLRPElAADPEArerFRREARALARLNHPNIVRVYDVGEEDGRpYLVMEYV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:COG0515  90 EGESLADLLRRR--GPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTGT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQ---GCPESLHELMNLC 506
Cdd:COG0515 168 VVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLT-GRPPFDGDSPAELLRAHLREPPPPPSElrpDLPPALDAIVLRA 246

                ....*....
gi 6678617  507 WKKDPDERP 515
Cdd:COG0515 247 LAKDPEERY 255
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
268-517 1.28e-45

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 163.64  E-value: 1.28e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPE--AFLQEAQIMKKLRHD-KLVPLYAVVS 338
Cdd:cd14207   2 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKsptcrvVAVKMLKEGATASEykALMTELKILIHIGHHlNVVNLLGACT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EE--PIYIVTEFMSKGSLLDFLK--------------------------------------------------------- 359
Cdd:cd14207  82 KSggPLMVIVEYCKYGNLSNYLKskrdffvtnkdtslqeelikekkeaeptggkkkrlesvtssesfassgfqedkslsd 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 -----EGDGKYLKLP----QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG- 429
Cdd:cd14207 162 veeeeEDSGDFYKRPltmeDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGd 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd14207 242 ARLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGASPYPGVqIDEDFCSKLKEGIRMRAPEFATSEIYQIMLDCWQ 321

                ....*....
gi 6678617  509 KDPDERPTF 517
Cdd:cd14207 322 GDPNERPRF 330
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
281-525 1.29e-45

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 160.64  E-value: 1.29e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtkVAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14062   1 IGSGSFGTVYKGRWHGD--VAVKKLNvtdPTPSQLQAFKNEVAVLRKTRHVNILLFMGYMTKPQLAIVTQWCEGSSLYKH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLieDNEYTARQGAKFP---I 434
Cdd:cd14062  79 LHVLETKF-EMLQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGLATV--KTRWSGSQQFEQPtgsI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWTAPEAAlygR------FTIKSDVWSFGILQTELVTkGRVPYPGMVNRE-VLEQVERGYRMP----CPQGCPESLHELM 503
Cdd:cd14062 156 LWMAPEVI---RmqdenpYSFQSDVYAFGIVLYELLT-GQLPYSHINNRDqILFMVGRGYLRPdlskVRSDTPKALRRLM 231
                       250       260
                ....*....|....*....|..
gi 6678617  504 NLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14062 232 EDCIKFQRDERPLFPQILASLE 253
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
268-526 2.94e-45

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 162.46  E-value: 2.94e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVVS 338
Cdd:cd05102   2 WEFPRDRLRLGKVLGHGAFGKVVEASAFGIDKssscetVAVKMLKEGATASEhkALMSELKILIHIgNHLNVVNLLGACT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EE--PIYIVTEFMSKGSLLDFLK---EGDGKY------------------------------------------------ 365
Cdd:cd05102  82 KPngPLMVIVEFCKYGNLSNFLRakrEGFSPYrersprtrsqvrsmveavradrrsrqgsdrvasftestsstnqprqev 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  366 -------LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-EDNEYTARQGAKFPIKWT 437
Cdd:cd05102 162 ddlwqspLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIyKDPDYVRKGSARLPLKWM 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  438 APEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd05102 242 APESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVqINEEFCQRLKDGTRMRAPEYATPEIYRIMLSCWHGDPKERPT 321
                       330
                ....*....|
gi 6678617  517 FEYIQSFLED 526
Cdd:cd05102 322 FSDLVEILGD 331
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
271-518 3.04e-45

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 160.51  E-value: 3.04e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVkLGQGCFGEVWMGTW--NGTT---KVAIKTL--KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY 343
Cdd:cd05111   6 ETELRKLKV-LGSGVFGTVHKGIWipEGDSikiPVAIKVIqdRSGRQSFQAVTDHMLAIGSLDHAYIVRLLGICPGASLQ 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--ED 421
Cdd:cd05111  85 LVTQLLPLGSLLDHVRQHRGS-LGPQLLLNWCVQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVADLLypDD 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQgAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 501
Cdd:cd05111 164 KKYFYSE-AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEMMTFGAEPYAGMRLAEVPDLLEKGERLAQPQICTIDVYM 242
                       250
                ....*....|....*..
gi 6678617  502 LMNLCWKKDPDERPTFE 518
Cdd:cd05111 243 VMVKCWMIDENIRPTFK 259
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
280-526 3.17e-45

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 160.95  E-value: 3.17e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTW-----NGTTKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVPLYAV---VSEEPIYIVTEFMS 350
Cdd:cd14205  11 QLGKGNFGSVEMCRYdplqdNTGEVVAVKKLQHSTEeHLRDFEREIEILKSLQHDNIVKYKGVcysAGRRNLRLIMEYLP 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-EDNEY-TARQ 428
Cdd:cd14205  91 YGSLRDYLQKHKER-IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLpQDKEYyKVKE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT---KGRVPyPG-------------MVNREVLEQVERGYRMPCP 492
Cdd:cd14205 170 PGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTyieKSKSP-PAefmrmigndkqgqMIVFHLIELLKNNGRLPRP 248
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  493 QGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14205 249 DGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ 282
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
281-516 1.12e-44

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 158.45  E-value: 1.12e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd06606   8 LGKGSFGSVYLALNLDTGElMAVKEVELSGDSEEeleALEREIRILSSLKHPNIVRyLGTERTENTLNIFLEYVPGGSLA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGakfP 433
Cdd:cd06606  88 SLLK----KFGKLPEPVvrKYTRQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAKRLAEIATGEGTK---S 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IK----WTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVERGYRMPC-PQGCPESLHELMNLCW 507
Cdd:cd06606 161 LRgtpyWMAPEVIRGEGYGRAADIWSLGCTVIEMAT-GKPPWSELGNPvAALFKIGSSGEPPPiPEHLSEEAKDFLRKCL 239

                ....*....
gi 6678617  508 KKDPDERPT 516
Cdd:cd06606 240 QRDPKKRPT 248
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
281-525 1.50e-44

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 158.59  E-value: 1.50e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMM--PEAFLQEAQIMKKLRHDKLVPLYAVVSE--EPIyIVTEFMSKGSLLD 356
Cdd:cd14066   1 IGSGGFGTVYKGVLENGTVVAVKRLNEMNCAasKKEFLTELEMLGRLRHPNLVRLLGYCLEsdEKL-LVYEYMPNGSLED 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKY-LKLPQLVDMAAQIADGMAYI---ERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG-AK 431
Cdd:cd14066  80 RLHCHKGSPpLPWPQRLKIAKGIARGLEYLheeCPPPIIHGDIKSSNILLDEDFEPKLTDFGLARLIPPSESVSKTSaVK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY-----PGMVN--REVLEQVERGYRM----PCPQGCPESLH 500
Cdd:cd14066 160 GTIGYLAPEYIRTGRVSTKSDVYSFGVVLLELLT-GKPAVdenreNASRKdlVEWVESKGKEELEdildKRLVDDDGVEE 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  501 ELMN-------LCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14066 239 EEVEallrlalLCTRSDPSLRPSMKEVVQMLE 270
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
268-531 1.56e-44

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 160.53  E-value: 1.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTK------VAIKTLKPGTMMPE--AFLQEAQIMKKLRHD-KLVPLYAVVS 338
Cdd:cd05103   2 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKtatcrtVAVKMLKEGATHSEhrALMSELKILIHIGHHlNVVNLLGACT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EE--PIYIVTEFMSKGSLLDFL----------KEGDGKY----------------------------------------- 365
Cdd:cd05103  82 KPggPLMVIVEFCKFGNLSAYLrskrsefvpyKTKGARFrqgkdyvgdisvdlkrrldsitssqssassgfveekslsdv 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  366 --------------LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-EDNEYTARQGA 430
Cdd:cd05103 162 eeeeagqedlykdfLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIyKDPDYVRKGDA 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKK 509
Cdd:cd05103 242 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVkIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHG 321
                       330       340
                ....*....|....*....|..
gi 6678617  510 DPDERPTFEYIQSFLEDYFTAT 531
Cdd:cd05103 322 EPSQRPTFSELVEHLGNLLQAN 343
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
281-525 3.68e-44

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 157.17  E-value: 3.68e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd14061   2 IGVGGFGKVYRGIWRGEE-VAVKAARQDpdediSVTLENVRQEARLFWMLRHPNIIALRGVCLQPPnLCLVMEYARGGAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGE--------NLICKIADFGLARLIEDne 423
Cdd:cd14061  81 NRVLA---GRKIPPHVLVDWAIQIARGMNYLHNeapVPIIHRDLKSSNILILEaienedleNKTLKITDFGLAREWHK-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 yTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGM----------VNREVLeqvergyrmPCPQ 493
Cdd:cd14061 156 -TTRMSAAGTYAWMAPEVIKSSTFSKASDVWSYGVLLWELLT-GEVPYKGIdglavaygvaVNKLTL---------PIPS 224
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  494 GCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14061 225 TCPEPFAQLMKDCWQPDPHDRPSFADILKQLE 256
SH2_Src_Lyn cd10364
Src homology 2 (SH2) domain found in Lyn; Lyn is a member of the Src non-receptor type ...
152-249 5.16e-44

Src homology 2 (SH2) domain found in Lyn; Lyn is a member of the Src non-receptor type tyrosine kinase family of proteins and is expressed in the hematopoietic cells, in neural tissues, liver, and adipose tissue. There are two alternatively spliced forms of Lyn. Lyn plays an inhibitory role in myeloid lineage proliferation. Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation, triggering a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phospholipase C2 (PLC2) and phosphatidyl inositol-3 kinase. These kinases play critical roles in proliferation, Ca2+ mobilization and cell differentiation. Lyn plays an essential role in the transmission of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins such as CD22, PIR-B and FC RIIb1. Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1 which further down modulate signaling pathways, attenuate cell activation and can mediate tolerance. Lyn also plays a role in the insulin signaling pathway. Activated Lyn phosphorylates insulin receptor substrate 1 (IRS1) leading to an increase in translocation of Glut-4 to the cell membrane and increased glucose utilization. It is the primary Src family member involved in signaling downstream of the B cell receptor. Lyn plays an unusual, 2-fold role in B cell receptor signaling; it is essential for initiation of signaling but is also later involved in negative regulation of the signal. Lyn has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198227  Cd Length: 101  Bit Score: 151.29  E-value: 5.16e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10364   1 ETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSYSLSVRDYDPQHGDVIKHYKIRSLDNGGYYISPRITFPCI 80
                        90
                ....*....|....*...
gi 6678617  232 QKLVKHYTEHADGLCHKL 249
Cdd:cd10364  81 SDMIKHYQKQSDGLCRRL 98
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
281-517 7.75e-44

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 156.46  E-value: 7.75e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEV---WMGTWNGttKVAIKTLKPGT---MMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGS 353
Cdd:cd13978   1 LGSGGFGTVskaRHVSWFG--MVAIKCLHSSPnciEERKALLKEAEKMERARHSYVLPLLGVcVERRSLGLVMEYMENGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK 431
Cdd:cd13978  79 LKSLLEREIQD-VPWSLRFRIIHEIALGMNFLHNMDppLLHHDLKPENILLDNHFHVKISDFGLSKLGMKSISANRRRGT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FP----IKWTAPEA--ALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQ-VERGYR-------MPCPQGCPE 497
Cdd:cd13978 158 ENlggtPIYMAPEAfdDFNKKPTSKSDVYSFAIVIWAVLT-RKEPFENAINPLLIMQiVSKGDRpslddigRLKQIENVQ 236
                       250       260
                ....*....|....*....|
gi 6678617  498 SLHELMNLCWKKDPDERPTF 517
Cdd:cd13978 237 ELISLMIRCWDGNPDARPTF 256
SH2_Src_Lck cd10362
Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck); Lck is a member of the Src ...
152-249 8.91e-44

Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck); Lck is a member of the Src non-receptor type tyrosine kinase family of proteins. It is expressed in the brain, T-cells, and NK cells. The unique domain of Lck mediates its interaction with two T-cell surface molecules, CD4 and CD8. It associates with their cytoplasmic tails on CD4 T helper cells and CD8 cytotoxic T cells to assist signaling from the T cell receptor (TCR) complex. When the T cell receptor is engaged by the specific antigen presented by MHC, Lck phosphorylase the intracellular chains of the CD3 and zeta-chains of the TCR complex, allowing ZAP-70 to bind them. Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates Linker of Activated T cells (LAT), a transmembrane protein that serves as a docking site for proteins including: Shc-Grb2-SOS, PI3K, and phospholipase C (PLC). The tyrosine phosphorylation cascade culminates in the intracellular mobilization of a calcium ions and activation of important signaling cascades within the lymphocyte, including the Ras-MEK-ERK pathway, which goes on to activate certain transcription factors such as NFAT, NF-kappaB, and AP-1. These transcription factors regulate the production cytokines such as Interleukin-2 that promote long-term proliferation and differentiation of the activated lymphocytes. The N-terminal tail of Lck is myristoylated and palmitoylated and it tethers the protein to the plasma membrane of the cell. Lck also contains a SH3 domain, a SH2 domain, and a C-terminal tyrosine kinase domain. Lck has 2 phosphorylation sites, the first an autophosphorylation site that is linked to activation of the protein and the second which is phosphorylated by Csk, which inhibits it. Lck is also inhibited by SHP-1 dephosphorylation and by Cbl ubiquitin ligase, which is part of the ubiquitin-mediated pathway. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198225  Cd Length: 101  Bit Score: 150.41  E-value: 8.91e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10362   1 EPEPWFFKNLSRNDAERQLLAPGNTHGSFLIRESETTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGL 80
                        90
                ....*....|....*...
gi 6678617  232 QKLVKHYTEHADGLCHKL 249
Cdd:cd10362  81 HELVRHYTNASDGLCTRL 98
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
281-526 6.49e-43

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 153.36  E-value: 6.49e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKPGTMMpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLK 359
Cdd:cd14058   1 VGRGSFGVVCKARWRNQI-VAVKIIESESEK-KAFEVEVRQLSRVDHPNIIKLYgACSNQKPVCLVMEYAEGGSLYNVLH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 EGDGK-YLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANILV---GENLicKIADFGLARLIEdNEYTARQGAkf 432
Cdd:cd14058  79 GKEPKpIYTAAHAMSWALQCAKGVAYLHSMKpkaLIHRDLKPPNLLLtngGTVL--KICDFGTACDIS-THMTNNKGS-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVN--REVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 510
Cdd:cd14058 154 -AAWMAPEVFEGSKYSEKCDVFSWGIILWEVITR-RKPFDHIGGpaFRIMWAVHNGERPPLIKNCPKPIESLMTRCWSKD 231
                       250
                ....*....|....*.
gi 6678617  511 PDERPTFEYIQSFLED 526
Cdd:cd14058 232 PEKRPSMKEIVKIMSH 247
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
281-525 2.30e-42

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 153.13  E-value: 2.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-----NGTTKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVPlYAVVSEEP----IYIVTEFMS 350
Cdd:cd05081  12 LGKGNFGSVELCRYdplgdNTGALVAVKQLQHSGPdQQRDFQREIQILKALHSDFIVK-YRGVSYGPgrrsLRLVMEYLP 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-EDNEY-TARQ 428
Cdd:cd05081  91 SGCLRDFLQRHRAR-LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLpLDKDYyVVRE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT---KGRVP---YPGMVNRE--------VLEQVERGYRMPCPQG 494
Cdd:cd05081 170 PGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTycdKSCSPsaeFLRMMGCErdvpalcrLLELLEEGQRLPAPPA 249
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  495 CPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd05081 250 CPAEVHELMKLCWAPSPQDRPSFSALGPQLD 280
PTKc_Tie2 cd05088
Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the ...
281-520 1.82e-41

Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie2 is a receptor PTK (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie2 is expressed mainly in endothelial cells and hematopoietic stem cells. It is also found in a subset of tumor-associated monocytes and eosinophils. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. Tie2 signaling plays key regulatory roles in vascular integrity and quiescence, and in inflammation. The Tie2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133219 [Multi-domain]  Cd Length: 303  Bit Score: 151.30  E-value: 1.82e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT---TKVAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVP--LYAVVSEEPIYIVTEFMSKGS 353
Cdd:cd05088  15 IGEGNFGQVLKARIKKDglrMDAAIKRMKEYASKDDHrdFAGELEVLCKLGHHPNIInlLGACEHRGYLYLAIEYAPHGN 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLK-----EGDGKY---------LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI 419
Cdd:cd05088  95 LLDFLRksrvlETDPAFaianstastLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EdnEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05088 175 E--VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEV 252
                       250       260
                ....*....|....*....|.
gi 6678617  500 HELMNLCWKKDPDERPTFEYI 520
Cdd:cd05088 253 YDLMRQCWREKPYERPSFAQI 273
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
281-520 2.52e-41

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 149.80  E-value: 2.52e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd14146   2 IGVGGFGKVYRATWKGQ-EVAVKAARQDpdediKATAESVRQEAKLFSMLRHPNIIKLEGVCLEEPnLCLVMEFARGGTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDG-----KYLKLPQ--LVDMAAQIADGMAYIERMNY---IHRDLRAANILVGENL----IC----KIADFGLA 416
Cdd:cd14146  81 NRALAAANAapgprRARRIPPhiLVNWAVQIARGMLYLHEEAVvpiLHRDLKSSNILLLEKIehddICnktlKITDFGLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RlieDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVE-RGYRMPCPQGC 495
Cdd:cd14146 161 R---EWHRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAvNKLTLPIPSTC 236
                       250       260
                ....*....|....*....|....*
gi 6678617  496 PESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd14146 237 PEPFAKLMKECWEQDPHIRPSFALI 261
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
266-525 5.25e-41

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 149.06  E-value: 5.25e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGttKVAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPI 342
Cdd:cd14151   1 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG--DVAVKMLNvtaPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA----RL 418
Cdd:cd14151  79 AIVTQWCEGSSLYHHLHIIETKF-EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAtvksRW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  419 IEDNEYTARQGAkfpIKWTAPEAALY---GRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVERGYRMP---- 490
Cdd:cd14151 158 SGSHQFEQLSGS---ILWMAPEVIRMqdkNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRdQIIFMVGRGYLSPdlsk 233
                       250       260       270
                ....*....|....*....|....*....|....*
gi 6678617  491 CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14151 234 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 268
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
276-516 5.66e-41

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 148.12  E-value: 5.66e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKG 352
Cdd:cd05122   3 EILEKIGKGGFGVVYKARHKKTGQiVAIKKINLESKEKkESILNEIAILKKCKHPNIVKYYgSYLKKDELWIVMEFCSGG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQGAK 431
Cdd:cd05122  83 SLKDLLKNTNKT-LTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSaQLSDGKTRNTFVGTP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG--YRMPCPQGCPESLHELMNLCWKK 509
Cdd:cd05122 162 Y---WMAPEVIQGKPYGFKADIWSLGITAIEMAE-GKPPYSELPPMKALFLIATNgpPGLRNPKKWSKEFKDFLKKCLQK 237

                ....*..
gi 6678617  510 DPDERPT 516
Cdd:cd05122 238 DPEKRPT 244
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
281-525 7.78e-41

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 147.26  E-value: 7.78e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPgtmmpeafLQEAQI--MKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDF 357
Cdd:cd14059   1 LGSGAQGAVFLGKFRGE-EVAVKKVRD--------EKETDIkhLRKLNHPNIIKFKGVCTQAPCYcILMEYCPYGQLYEV 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKegDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNeyTARQGAKFPIKWT 437
Cdd:cd14059  72 LR--AGREITPSLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEK--STKMSFAGTVAWM 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  438 APEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14059 148 APEVIRNEPCSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLQLPVPSTCPDGFKLLMKQCWNSKPRNRPS 226

                ....*....
gi 6678617  517 FEYIQSFLE 525
Cdd:cd14059 227 FRQILMHLD 235
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
268-525 1.42e-40

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 148.26  E-value: 1.42e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVWMGTWNGttKVAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI 344
Cdd:cd14149   7 WEIEASEVMLSTRIGSGSFGTVYKGKWHG--DVAVKILKVVDPTPEqfqAFRNEVAVLRKTRHVNILLFMGYMTKDNLAI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLieDNEY 424
Cdd:cd14149  85 VTQWCEGSSLYKHLHVQETKF-QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFP---IKWTAPEAALY---GRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVERGYRMP----CPQ 493
Cdd:cd14149 162 SGSQQVEQPtgsILWMAPEVIRMqdnNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRdQIIFMVGRGYASPdlskLYK 240
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  494 GCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14149 241 NCPKAMKRLVADCIKKVKEERPLFPQILSSIE 272
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
273-525 3.85e-40

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 146.33  E-value: 3.85e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTkVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVT 346
Cdd:cd14147   3 QELRLEEVIGIGGFGKVYRGSWRGEL-VAVKAARQDpdediSVTAESVRQEARLFAMLAHPNIIALKAVCLEEPnLCLVM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVG--------ENLICKIADFGL 415
Cdd:cd14147  82 EYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLHCealVPVIHRDLKSNNILLLqpienddmEHKTLKITDFGL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  416 ARlieDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVE-RGYRMPCPQG 494
Cdd:cd14147 159 AR---EWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAvNKLTLPIPST 234
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  495 CPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14147 235 CPEPFAQLMADCWAQDPHRRPDFASILQQLE 265
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
276-516 4.63e-40

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 145.83  E-value: 4.63e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMG-TWNGTTKVAIKTLKPgTMMPEAFLQ----EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFM 349
Cdd:cd06627   3 QLGDLIGRGAFGSVYKGlNLNTGEFVAIKQISL-EKIPKSDLKsvmgEIDLLKKLNHPNIVKYIGSVkTKDSLYIILEYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKegdgKYLKLPQ-LVDM-AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIE-DNEYT 425
Cdd:cd06627  82 ENGSLASIIK----KFGKFPEsLVAVyIYQVLEGLAYLHEQGVIHRDIKGANILTTKDGLVKLADFGVAtKLNEvEKDEN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd06627 158 SVVGTPY---WMAPEVIEMSGVTTASDIWSVGCTVIELLT-GNPPYYDLQPMAALFRIVQDDHPPLPENISPELRDFLLQ 233
                       250
                ....*....|.
gi 6678617  506 CWKKDPDERPT 516
Cdd:cd06627 234 CFQKDPTLRPS 244
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
282-525 5.95e-40

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 145.10  E-value: 5.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  282 GQGCFGEVWMGTWNGTTK-VAIKTLKpgtmmpeAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLK 359
Cdd:cd14060   2 GGGSFGSVYRAIWVSQDKeVAVKKLL-------KIEKEAEILSVLSHRNIIQFYGAILEAPNYgIVTEYASYGSLFDYLN 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 EGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAkFPikW 436
Cdd:cd14060  75 SNESEEMDMDQIMTWATDIAKGMHYLHMeapVKVIHRDLKSRNVVIAADGVLKICDFGASRFHSHTTHMSLVGT-FP--W 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  437 TAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVL-EQVERGYRMPCPQGCPESLHELMNLCWKKDPDERP 515
Cdd:cd14060 152 MAPEVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAwLVVEKNERPTIPSSCPRSFAELMRRCWEADVKERP 230
                       250
                ....*....|
gi 6678617  516 TFEYIQSFLE 525
Cdd:cd14060 231 SFKQIIGILE 240
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
269-520 1.46e-39

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 145.18  E-value: 1.46e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTtKVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-I 342
Cdd:cd14145   2 EIDFSELVLEEIIGIGGFGKVYRAIWIGD-EVAVKAARHDpdediSQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPnL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGE--------NLICKIA 411
Cdd:cd14145  81 CLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIARGMNYLHCeaiVPVIHRDLKSSNILILEkvengdlsNKILKIT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARlieDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP 490
Cdd:cd14145 158 DFGLAR---EWHRTTKMSAAGTYAWMAPEVIRSSMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNkLSLP 233
                       250       260       270
                ....*....|....*....|....*....|
gi 6678617  491 CPQGCPESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd14145 234 IPSTCPEPFARLMEDCWNPDPHSRPPFTNI 263
SH2_Src_Blk cd10371
Src homology 2 (SH2) domain found in B lymphoid kinase (Blk); Blk is a member of the Src ...
152-250 1.59e-39

Src homology 2 (SH2) domain found in B lymphoid kinase (Blk); Blk is a member of the Src non-receptor type tyrosine kinase family of proteins. Blk is expressed in the B-cells. Unlike most other Src members Blk lacks cysteine residues in the SH4 domain that undergo palmitylation. Blk is required for the development of IL-17-producing gamma-delta T cells. Furthermore, Blk is expressed in lymphoid precursors and, in this capacity, plays a role in regulating thymus cellularity during ontogeny. Blk has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198234 [Multi-domain]  Cd Length: 100  Bit Score: 139.00  E-value: 1.59e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWdEVRGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10371   1 EVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDV-TTQGEVVKHYKIRSLDNGGYYISPRITFPTL 79
                        90
                ....*....|....*....
gi 6678617  232 QKLVKHYTEHADGLCHKLT 250
Cdd:cd10371  80 QALVQHYSKKGDGLCQKLT 98
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
280-525 2.11e-39

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 144.39  E-value: 2.11e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGttKVAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLD 356
Cdd:cd14150   7 RIGTGSFGTVFRGKWHG--DVAVKILKvtePTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQWCEGSSLYR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLieDNEYTARQGAKFP--- 433
Cdd:cd14150  85 HLHVTETRF-DTMQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV--KTRWSGSQQVEQPsgs 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IKWTAPEAALY---GRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVERGYRMP----CPQGCPESLHELMNL 505
Cdd:cd14150 162 ILWMAPEVIRMqdtNPYSFQSDVYAYGVVLYELMS-GTLPYSNINNRdQIIFMVGRGYLSPdlskLSSNCPKAMKRLLID 240
                       250       260
                ....*....|....*....|
gi 6678617  506 CWKKDPDERPTFEYIQSFLE 525
Cdd:cd14150 241 CLKFKREERPLFPQILVSIE 260
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
281-526 6.02e-39

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 142.82  E-value: 6.02e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd14148   2 IGVGGFGKVYKGLWRGE-EVAVKAARQDpdediAVTAENVRQEARLFWMLQHPNIIALRGVCLNPPhLCLVMEYARGGAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdGKYLKLPQLVDMAAQIADGMAYIERMNY---IHRDLRAANILVGE--------NLICKIADFGLARlieDNE 423
Cdd:cd14148  81 NRALA---GKKVPPHVLVNWAVQIARGMNYLHNEAIvpiIHRDLKSSNILILEpienddlsGKTLKITDFGLAR---EWH 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYpgmvnREV-LEQVERGYRM-----PCPQGCPE 497
Cdd:cd14148 155 KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPY-----REIdALAVAYGVAMnkltlPIPSTCPE 228
                       250       260
                ....*....|....*....|....*....
gi 6678617  498 SLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14148 229 PFARLLEECWDPDPHGRPDFGSILKRLED 257
SH2_Src_Src42 cd10370
Src homology 2 (SH2) domain found in the Src oncogene at 42A (Src42); Src42 is a member of the ...
152-249 9.15e-39

Src homology 2 (SH2) domain found in the Src oncogene at 42A (Src42); Src42 is a member of the Src non-receptor type tyrosine kinase family of proteins. The integration of receptor tyrosine kinase-induced RAS and Src42 signals by Connector eNhancer of KSR (CNK) as a two-component input is essential for RAF activation in Drosophila. Src42 is present in a wide variety of organisms including: California sea hare, pea aphid, yellow fever mosquito, honey bee, Panamanian leafcutter ant, and sea urchin. Src42 has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its C-terminal tail. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198233  Cd Length: 96  Bit Score: 136.87  E-value: 9.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10370   1 EAEPWYFGKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTL 75
                        90
                ....*....|....*...
gi 6678617  232 QKLVKHYTEHADGLCHKL 249
Cdd:cd10370  76 QELVEHYSKDSDGLCVNL 93
SH3_Yes cd12007
Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src ...
92-149 4.76e-38

Src homology 3 domain of Yes Protein Tyrosine Kinase; Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212940 [Multi-domain]  Cd Length: 58  Bit Score: 133.62  E-value: 4.76e-38
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617   92 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPAD 149
Cdd:cd12007   1 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPAD 58
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
276-522 1.87e-35

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 133.03  E-value: 1.87e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd14003   3 ELGKTLGEGSFGKVKLARHKLTgEKVAIKIIdksKLKEEIEEKIKREIEIMKLLNHPNIIKLYEVIeTENKIYLVMEYAS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDF------LKEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd14003  83 GGELFDYivnngrLSEDEARRF--------FQQLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFRGGSL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQ-GAKFpikWTAPEaALYGR--FTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYrMPCPQGCPESLHE 501
Cdd:cd14003 155 LKTFcGTPA---YAAPE-VLLGRkyDGPKADVWSLGVILYAMLT-GYLPFDDDNDSKLFRKILKGK-YPIPSHLSPDARD 228
                       250       260
                ....*....|....*....|.
gi 6678617  502 LMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14003 229 LIRRMLVVDPSKRITIEEILN 249
PTKc_Aatyk1 cd05087
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs ...
280-524 2.16e-35

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk1 (or simply Aatyk) is also called lemur tyrosine kinase 1 (Lmtk1). It is a cytoplasmic (or nonreceptor) kinase containing a long C-terminal region. The expression of Aatyk1 is upregulated during growth arrest and apoptosis in myeloid cells. Aatyk1 has been implicated in neural differentiation, and is a regulator of the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation and survival, epithelial transport, and blood pressure control. The Aatyk1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270670 [Multi-domain]  Cd Length: 271  Bit Score: 133.57  E-value: 2.16e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWN---GTTKVAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGS 353
Cdd:cd05087   4 EIGHGWFGKVFLGEVNsglSSTQVVVKELKASASVQDQmqFLEEAQPYRALQHTNLLQCLAQCAEvTPYLLVMEFCPLGD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQ---LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd05087  84 LKGYLRSCRAAESMAPDpltLQRMACEVACGLLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLSHCKYKEDYFVTADQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KF-PIKWTAPEAA--LYGRF-----TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV--ERGYRMPCPQ---GCPE 497
Cdd:cd05087 164 LWvPLRWIAPELVdeVHGNLlvvdqTKQSNVWSLGVTIWELFELGNQPYRHYSDRQVLTYTvrEQQLKLPKPQlklSLAE 243
                       250       260
                ....*....|....*....|....*..
gi 6678617  498 SLHELMNLCWKKdPDERPTFEYIQSFL 524
Cdd:cd05087 244 RWYEVMQFCWLQ-PEQRPTAEEVHLLL 269
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
281-517 1.35e-34

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 130.69  E-value: 1.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIktLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14065   1 LGKGFFGEVYKVTHRETGKVMV--MKELKRFDEqrSFLKEVKLMRRLSHPNILRFIGVcVKDNKLNFITEYVNGGTLEEL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLIckIADFGLARLIEDneYTARQGA-K 431
Cdd:cd14065  79 LKSMDEQL-PWSQRVSLAKDIASGMAYLHSKNIIHRDLNSKNCLVreanrGRNAV--VADFGLAREMPD--EKTKKPDrK 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIK------WTAPEaALYGR-FTIKSDVWSFGILQTELVtkGRVPypgmVNREVLEQVE------RGYRMPCPQGCPES 498
Cdd:cd14065 154 KRLTvvgspyWMAPE-MLRGEsYDEKVDVFSFGIVLCEII--GRVP----ADPDYLPRTMdfgldvRAFRTLYVPDCPPS 226
                       250
                ....*....|....*....
gi 6678617  499 LHELMNLCWKKDPDERPTF 517
Cdd:cd14065 227 FLPLAIRCCQLDPEKRPSF 245
SH2_Src_Frk cd10369
Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk); Frk is a member of the Src ...
152-249 1.93e-34

Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk); Frk is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily is composed of Frk/Rak and Iyk/Bsk/Gst. It is expressed primarily epithelial cells. Frk is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. Unlike the other Src members it lacks a glycine at position 2 of SH4 which is important for addition of a myristic acid moiety that is involved in targeting Src PTKs to cellular membranes. FRK and SHB exert similar effects when overexpressed in rat phaeochromocytoma (PC12) and beta-cells, where both induce PC12 cell differentiation and beta-cell proliferation. Under conditions that cause beta-cell degeneration these proteins augment beta-cell apoptosis. The FRK-SHB responses involve FAK and insulin receptor substrates (IRS) -1 and -2. Frk has been demonstrated to interact with retinoblastoma protein. Frk regulates PTEN protein stability by phosphorylating PTEN, which in turn prevents PTEN degradation. Frk also plays a role in regulation of embryonal pancreatic beta cell formation. Frk has a unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail, as do the other members of the family. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its activation loop. The tryosine involved is at the same site as the tyrosine involved in the autophosphorylation of Src. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 199831  Cd Length: 96  Bit Score: 124.99  E-value: 1.93e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGYYITTRAQFDTL 231
Cdd:cd10369   1 QAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGEFSLSVLD-----GGVVKHYRIRRLDEGGFFLTRRKTFSTL 75
                        90
                ....*....|....*...
gi 6678617  232 QKLVKHYTEHADGLCHKL 249
Cdd:cd10369  76 NEFVNYYTTTSDGLCVKL 93
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
281-525 2.56e-34

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 130.71  E-value: 2.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAI-KTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14154   1 LGKGFFGQAIKVTHRETGEVMVmKELiRFDEEAQRNFLKEVKVMRSLDHPNVLKFIGVLyKDKKLNLITEYIPGGTLKDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK-- 435
Cdd:cd14154  81 LKDMA-RPLPWAQRVRFAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARLIVEERLPSGNMSPSETLrh 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 -----------------WTAPEaALYGR-FTIKSDVWSFGILQTELVtkGRVPY-PGMVNREVLEQV-ERGYRMPCPQGC 495
Cdd:cd14154 160 lkspdrkkrytvvgnpyWMAPE-MLNGRsYDEKVDIFSFGIVLCEII--GRVEAdPDYLPRTKDFGLnVDSFREKFCAGC 236
                       250       260       270
                ....*....|....*....|....*....|
gi 6678617  496 PESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14154 237 PPPFFKLAFLCCDLDPEKRPPFETLEEWLE 266
SH2_SLAP cd10344
Src homology 2 domain found in Src-like adaptor proteins; SLAP belongs to the subfamily of ...
141-246 5.65e-34

Src homology 2 domain found in Src-like adaptor proteins; SLAP belongs to the subfamily of adapter proteins that negatively regulate cellular signaling initiated by tyrosine kinases. It has a myristylated N-terminus, SH3 and SH2 domains with high homology to Src family tyrosine kinases, and a unique C-terminal tail, which is important for c-Cbl binding. SLAP negatively regulates platelet-derived growth factor (PDGF)-induced mitogenesis in fibroblasts and regulates F-actin assembly for dorsal ruffles formation. c-Cbl mediated SLAP inhibition towards actin remodeling. Moreover, SLAP enhanced PDGF-induced c-Cbl phosphorylation by SFK. In contrast, SLAP mitogenic inhibition was not mediated by c-Cbl, but it rather involved a competitive mechanism with SFK for PDGF-receptor (PDGFR) association and mitogenic signaling. Accordingly, phosphorylation of the Src mitogenic substrates Stat3 and Shc were reduced by SLAP. Thus, we concluded that SLAP regulates PDGFR signaling by two independent mechanisms: a competitive mechanism for PDGF-induced Src mitogenic signaling and a non-competitive mechanism for dorsal ruffles formation mediated by c-Cbl. SLAP is a hematopoietic adaptor containing Src homology (SH)3 and SH2 motifs and a unique carboxy terminus. Unlike c-Src, SLAP lacks a tyrosine kinase domain. Unlike c-Src, SLAP does not impact resorptive function of mature osteoclasts but induces their early apoptosis. SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors. Conversely, SLAP decreases osteoclast death by inhibiting activation of caspase 3. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198207  Cd Length: 104  Bit Score: 124.14  E-value: 5.65e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  141 PSNYVVPAdsiqAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGY 220
Cdd:cd10344   1 PSNYVAKV----YHGWLFEGLSREKAEELLMLPGNQVGSFLIRESETRRGCYSLSVRHRGSQSRDSVKHYRIFRLDNGWF 76
                        90       100
                ....*....|....*....|....*.
gi 6678617  221 YITTRAQFDTLQKLVKHYTEHADGLC 246
Cdd:cd10344  77 YISPRLTFQCLEDMVNHYSESADGLC 102
SH2 pfam00017
SH2 domain;
156-238 9.81e-34

SH2 domain;


Pssm-ID: 425423 [Multi-domain]  Cd Length: 77  Bit Score: 122.32  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    156 WYFGKMGRKDAERLLLNpGNQRGIFLVRESETTKGAYSLSIRDWDevrgdNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:pfam00017   1 WYHGKISRQEAERLLLN-GKPDGTFLVRESESTPGGYTLSVRDDG-----KVKHYKIQSTDNGGYYISGGVKFSSLAELV 74

                  ...
gi 6678617    236 KHY 238
Cdd:pfam00017  75 EHY 77
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
300-524 1.28e-33

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 128.66  E-value: 1.28e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  300 VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKylklpqlVD----- 373
Cdd:cd13992  28 VAIKHITFSRTEKRTILQELNQLKELVHDNLNKFIGICINPPnIAVVTEYCTRGSLQDVLLNREIK-------MDwmfks 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  374 -MAAQIADGMAYIERMNYI-HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK--WTAPE----AALYG 445
Cdd:cd13992 101 sFIKDIVKGMNYLHSSSIGyHGRLKSSNCLVDSRWVVKLTDFGLRNLLEEQTNHQLDEDAQHKKllWTAPEllrgSLLEV 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  446 RFTIKSDVWSFGILQTELVTKGRvPYPGMVNREVLEQVER-GYRMPCPQ------GCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd13992 181 RGTQKGDVYSFAIILYEILFRSD-PFALEREVAIVEKVISgGNKPFRPElavlldEFPPRLVLLVKQCWAENPEKRPSFK 259

                ....*.
gi 6678617  519 YIQSFL 524
Cdd:cd13992 260 QIKKTL 265
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
281-526 2.81e-33

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 127.76  E-value: 2.81e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAI--KTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14221   1 LGKGCFGQAIKVTHRETGEVMVmkELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLyKDKRLNFITEYIKGGTLRGI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYTARQGAKFPIK 435
Cdd:cd14221  81 IKSMDSHY-PWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMvdEKTQPEGLRSLKKPDR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 -----------WTAPEaALYGR-FTIKSDVWSFGILQTELVtkGRVPYP----------GMVNREVLEQVergyrmpCPQ 493
Cdd:cd14221 160 kkrytvvgnpyWMAPE-MINGRsYDEKVDVFSFGIVLCEII--GRVNADpdylprtmdfGLNVRGFLDRY-------CPP 229
                       250       260       270
                ....*....|....*....|....*....|...
gi 6678617  494 GCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14221 230 NCPPSFFPIAVLCCDLDPEKRPSFSKLEHWLET 262
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
280-520 3.33e-33

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 127.19  E-value: 3.33e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd08215   7 VIGKGSFGSAYLVRRKSDGKlYVLKEIDLSNMSEkerEEALNEVKLLSKLKHPNIVKYYESFEENGkLCIVMEYADGGDL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKE--GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARqgakf 432
Cdd:cd08215  87 AQKIKKqkKKGQPFPEEQILDWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFGISKVLESTTDLAK----- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pikwT--------APEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd08215 162 ----TvvgtpyylSPELCENKPYNYKSDIWALGCVLYELCT-LKHPFEANNLPALVYKIVKGQYPPIPSQYSSELRDLVN 236
                       250
                ....*....|....*.
gi 6678617  505 LCWKKDPDERPTFEYI 520
Cdd:cd08215 237 SMLQKDPEKRPSANEI 252
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
281-518 9.58e-33

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 125.80  E-value: 9.58e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 355
Cdd:cd14009   1 IGRGSFATVWKGRHKQTgEVVAIKEISRKKLNKklqENLESEIAILKSIKHPNIVRLYDVQkTEDFIYLVLEYCAGGDLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLIEDNEYTARQ-G 429
Cdd:cd14009  81 QYIR----KRGRLPEAVarHFMQQLASGLKFLRSKNIIHRDLKPQNLLLstsGDDPVLKIADFGFARSLQPASMAETLcG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW-- 507
Cdd:cd14009 157 SPL---YMAPEILQFQKYDAKADLWSVGAILFEMLV-GKPPFRGSNHVQLLRNIERSDAVIPFPIAAQLSPDCKDLLRrl 232
                       250
                ....*....|..
gi 6678617  508 -KKDPDERPTFE 518
Cdd:cd14009 233 lRRDPAERISFE 244
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
280-525 1.47e-32

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 125.92  E-value: 1.47e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGttKVAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLL 355
Cdd:cd14063   7 VIGKGRFGRVHRGRWHG--DVAIKLLNIDYLNEEqleAFKEEVAAYKNTRHDNLVLFMGACMDPPHLaIVTSLCKGRTLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICkIADFGLARLIEDNEYTARQGA-KFPI 434
Cdd:cd14063  85 SLIHERKEK-FDFNKTVQIAQQICQGMGYLHAKGIIHKDLKSKNIFLENGRVV-ITDFGLFSLSGLLQPGRREDTlVIPN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWT---APEAALYGR----------FTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQ-GCPESLH 500
Cdd:cd14063 163 GWLcylAPEIIRALSpdldfeeslpFTKASDVYAFGTVWYELLA-GRWPFKEQPAESIIWQVGCGKKQSLSQlDIGREVK 241
                       250       260
                ....*....|....*....|....*
gi 6678617  501 ELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14063 242 DILMQCWAYDPEKRPTFSDLLRMLE 266
Pkinase pfam00069
Protein kinase domain;
275-518 6.03e-32

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 122.35  E-value: 6.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    275 LRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFM 349
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKiVAIKKIKkekIKKKKDKNILREIKILKKLNHPNIVRLYDAFEDKDnLYLVLEYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    350 SKGSLLDFLKEgdGKYLKLPQLVDMAAQIADGMAYiermnyihrdlraanilvgenlickiadfglarlieDNEYTARQG 429
Cdd:pfam00069  81 EGGSLFDLLSE--KGAFSEREAKFIMKQILEGLES------------------------------------GSSLTTFVG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    430 AKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV--ERGYRMPCPQGCPESLHELMNLCW 507
Cdd:pfam00069 123 TPW---YMAPEVLGGNPYGPKVDVWSLGCILYELLT-GKPPFPGINGNEIYELIidQPYAFPELPSNLSEEAKDLLKKLL 198
                         250
                  ....*....|.
gi 6678617    508 KKDPDERPTFE 518
Cdd:pfam00069 199 KKDPSKRLTAT 209
PTKc_Aatyk cd05042
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs ...
280-524 9.12e-32

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Aatyk subfamily is also referred to as the lemur tyrosine kinase (Lmtk) subfamily. It consists of Aatyk1 (Lmtk1), Aatyk2 (Lmtk2, Brek), Aatyk3 (Lmtk3), and similar proteins. Aatyk proteins are mostly receptor PTKs (RTKs) containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk1 does not contain a transmembrane segment and is a cytoplasmic (or nonreceptor) kinase. Aatyk proteins are classified as PTKs based on overall sequence similarity and the phylogenetic tree. However, analysis of catalytic residues suggests that Aatyk proteins may be multispecific kinases, functioning also as serine/threonine kinases. They are involved in neural differentiation, nerve growth factor (NGF) signaling, apoptosis, and spermatogenesis. The Aatyk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270638 [Multi-domain]  Cd Length: 269  Bit Score: 123.47  E-value: 9.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG-TWNGTT--KVAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGS 353
Cdd:cd05042   2 EIGNGWFGKVLLGeIYSGTSvaQVVVKELKASANPKEqdTFLKEGQPYRILQHPNILQCLGQCVEAiPYLLVMEFCDLGD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQ---LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA--RLIEDNEYTARQ 428
Cdd:cd05042  82 LKAYLRSEREHERGDSDtrtLQRMACEVAAGLAHLHKLNFVHSDLALRNCLLTSDLTVKIGDYGLAhsRYKEDYIETDDK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 gAKFPIKWTAPE--AALYGRF-----TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV--ERGYRMPCPQ---GCP 496
Cdd:cd05042 162 -LWFPLRWTAPElvTEFHDRLlvvdqTKYSNIWSLGVTLWELFENGAQPYSNLSDLDVLAQVvrEQDTKLPKPQlelPYS 240
                       250       260
                ....*....|....*....|....*...
gi 6678617  497 ESLHELMNLCWKKdPDERPTFEYIQSFL 524
Cdd:cd05042 241 DRWYEVLQFCWLS-PEQRPAAEDVHLLL 267
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
280-516 6.56e-31

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 120.66  E-value: 6.56e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSL 354
Cdd:cd05117   7 VLGRGSFGVVRLAVHKKTgEEYAVKIIdkkKLKSEDEEMLRREIEILKRLDHPNIVKLYEVfEDDKNLYLVMELCTGGEL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLIEDNEY-TARQGA 430
Cdd:cd05117  87 FDRIVKK--GSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLaskDPDSPIKIIDFGLAKIFEEGEKlKTVCGT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 kfpIKWTAPE---AALYGRftiKSDVWSFG-ILQTELVtkGRVPYPGMVNREVLEQVERG-YRMPCPQ--GCPESLHELM 503
Cdd:cd05117 165 ---PYYVAPEvlkGKGYGK---KCDIWSLGvILYILLC--GYPPFYGETEQELFEKILKGkYSFDSPEwkNVSEEAKDLI 236
                       250
                ....*....|...
gi 6678617  504 NLCWKKDPDERPT 516
Cdd:cd05117 237 KRLLVVDPKKRLT 249
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
281-517 1.00e-30

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 120.68  E-value: 1.00e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLD 356
Cdd:cd14027   1 LDSGGFGKVSLCFHRTQGLVVLKTVYTGPNCIEhneALLEEGKMMNRLRHSRVVKLLGVILEEGKYsLVMEYMEKGNLMH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEgdgkyLKLPQLVD--MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA------RLieDNEYTARQ 428
Cdd:cd14027  81 VLKK-----VSVPLSVKgrIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAsfkmwsKL--TKEEHNEQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 --------GAKFPIKWTAPE--AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVL----EQVERGYRMPCPQG 494
Cdd:cd14027 154 revdgtakKNAGTLYYMAPEhlNDVNAKPTEKSDVYSFAIVLWAIFA-NKEPYENAINEDQIimciKSGNRPDVDDITEY 232
                       250       260
                ....*....|....*....|...
gi 6678617  495 CPESLHELMNLCWKKDPDERPTF 517
Cdd:cd14027 233 CPREIIDLMKLCWEANPEARPTF 255
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
279-520 1.04e-30

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 120.01  E-value: 1.04e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  279 VKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLD 356
Cdd:cd06614   6 EKIGEGASGEVYKATDRATGKeVAIKKMRLRKQNKELIINEILIMKECKHPNIVDYYdSYLVGDELWVVMEYMDGGSLTD 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIedneyTARQGAKFPI-- 434
Cdd:cd06614  86 II-TQNPVRMNESQIAYVCREVLQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQL-----TKEKSKRNSVvg 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 --KWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmvnrevleqvergYRMPcP---------QGCPE------ 497
Cdd:cd06614 160 tpYWMAPEVIKRKDYGPKVDIWSLGIMCIEMA-EGEPPY---------------LEEP-PlralflittKGIPPlknpek 222
                       250       260
                ....*....|....*....|....*.
gi 6678617  498 ---SLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd06614 223 wspEFKDFLNKCLVKDPEKRPSAEEL 248
PK_GC-A_B cd14042
Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The ...
291-524 1.49e-30

Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-A binds and is activated by the atrial and B-type natriuretic peptides, ANP and BNP, which are important in blood pressure regulation and cardiac pathophysiology. GC-B binds the C-type natriuretic peptide, CNP, which is a potent vasorelaxant and functions in vascular remodeling and bone growth regulation. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-A/B subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270944 [Multi-domain]  Cd Length: 279  Bit Score: 120.39  E-value: 1.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  291 MGTWNGTtKVAIK-TLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLkEGDGkyLKL 368
Cdd:cd14042  25 TGYYKGN-LVAIKkVNKKRIDLTREVLKELKHMRDLQHDNLTRFIGACVDPPnICILTEYCPKGSLQDIL-ENED--IKL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  369 PQL--VDMAAQIADGMAYIE----RMnyiHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK-WTAPE- 440
Cdd:cd14042 101 DWMfrYSLIHDIVKGMHYLHdseiKS---HGNLKSSNCVVDSRFVLKITDFGLHSFRSGQEPPDDSHAYYAKLlWTAPEl 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  441 ---AALYGRFTIKSDVWSFGILQTELVTKGRVPY---PGMVNREVLEQ-VERGYRMP-----CPQGCPESLHELMNLCWK 508
Cdd:cd14042 178 lrdPNPPPPGTQKGDVYSFGIILQEIATRQGPFYeegPDLSPKEIIKKkVRNGEKPPfrpslDELECPDEVLSLMQRCWA 257
                       250
                ....*....|....*.
gi 6678617  509 KDPDERPTFEYIQSFL 524
Cdd:cd14042 258 EDPEERPDFSTLRNKL 273
SH3_Fyn_Yrk cd12006
Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases; Fyn and Yrk (Yes-related kinase) ...
92-147 1.53e-30

Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases; Fyn and Yrk (Yes-related kinase) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212939 [Multi-domain]  Cd Length: 56  Bit Score: 113.22  E-value: 1.53e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617   92 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVP 147
Cdd:cd12006   1 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP 56
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
280-528 4.78e-30

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 119.18  E-value: 4.78e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKpgtmmpEAF--------LQEAQIMKKL-RHDKLVPLYAVVSE-EPIYIVTEF 348
Cdd:cd07830   6 QLGDGTFGSVYLARNKETgELVAIKKMK------KKFysweecmnLREVKSLRKLnEHPNIVKLKEVFREnDELYFVFEY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MsKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-YTA- 426
Cdd:cd07830  80 M-EGNLYQLMKDRKGKPFSESVIRSIIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAREIRSRPpYTDy 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 ---RqgakfpikW-TAPEAALygRFTIKS---DVWSFGILQTELVTkGRVPYPG-----MVNR--EVLEQVER------- 485
Cdd:cd07830 159 vstR--------WyRAPEILL--RSTSYSspvDIWALGCIMAELYT-LRPLFPGsseidQLYKicSVLGTPTKqdwpegy 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  486 ------GYRMpcPQGCPESLH-----------ELMNLCWKKDPDERPTFEyiQSFLEDYF 528
Cdd:cd07830 228 klasklGFRF--PQFAPTSLHqlipnaspeaiDLIKDMLRWDPKKRPTAS--QALQHPYF 283
SH3_Src_like cd11845
Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases; Src subfamily members ...
93-144 8.22e-30

Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases; Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, Yes, and Brk. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). However, Brk lacks the N-terminal myristoylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells, and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, Lyn, and Brk show a limited expression pattern. This subfamily also includes Drosophila Src42A, Src oncogene at 42A (also known as Dsrc41) which accumulates at sites of cell-cell or cell-matrix adhesion, and participates in Drosphila development and wound healing. It has been shown to promote tube elongation in the tracheal system, is essential for proper cell-cell matching during dorsal closure, and regulates cell-cell contacts in developing Drosophila eyes. The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212779 [Multi-domain]  Cd Length: 52  Bit Score: 110.75  E-value: 8.22e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNY 144
Cdd:cd11845   1 IYVALYDYEARTDDDLSFKKGDRLQILDDSDGDWWLARHLSTGKEGYIPSNY 52
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
281-516 1.14e-29

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 117.50  E-value: 1.14e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGtWNGTTK--VAIKTL------KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSK 351
Cdd:cd06632   8 LGSGSFGSVYEG-FNGDTGdfFAVKEVslvdddKKSRESVKQLEQEIALLSKLRHPNIVQYYGTeREEDNLYIFLEYVPG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTAR-QGA 430
Cdd:cd06632  87 GSIHKLLQRYGA--FEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGMAKHVEAFSFAKSfKGS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFpikWTAPE--AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPcpqGCPESL----HELMN 504
Cdd:cd06632 165 PY---WMAPEviMQKNSGYGLAVDIWSLGCTVLEMAT-GKPPWSQYEGVAAIFKIGNSGELP---PIPDHLspdaKDFIR 237
                       250
                ....*....|..
gi 6678617  505 LCWKKDPDERPT 516
Cdd:cd06632 238 LCLQRDPEDRPT 249
SH2 smart00252
Src homology 2 domains; Src homology 2 domains bind phosphotyrosine-containing polypeptides ...
154-244 1.35e-29

Src homology 2 domains; Src homology 2 domains bind phosphotyrosine-containing polypeptides via 2 surface pockets. Specificity is provided via interaction with residues that are distinct from the phosphotyrosine. Only a single occurrence of a SH2 domain has been found in S. cerevisiae.


Pssm-ID: 214585 [Multi-domain]  Cd Length: 84  Bit Score: 111.17  E-value: 1.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617     154 EEWYFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGYYITTRAQFDTLQK 233
Cdd:smart00252   1 QPWYHGFISREEAEKLLKNEGD--GDFLVRDSESSPGDYVLSVRV-----KGKVKHYRIRRNEDGKFYLEGGRKFPSLVE 73
                           90
                   ....*....|.
gi 6678617     234 LVKHYTEHADG 244
Cdd:smart00252  74 LVEHYQKNSLG 84
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
273-516 2.46e-29

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 116.54  E-value: 2.46e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPG--TMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEF 348
Cdd:cd06623   1 SDLERVKVLGQGSSGVVYKVRHKPTGKiYALKKIHVDgdEEFRKQLLRELKTLRSCESPYVVKCYgAFYKEGEISIVLEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKegdgKYLKLP--QLVDMAAQIADGMAYIERM-NYIHRDLRAANILVGENLICKIADFGLARLIE---DN 422
Cdd:cd06623  81 MDGGSLADLLK----KVGKIPepVLAYIARQILKGLDYLHTKrHIIHRDIKPSNLLINSKGEVKIADFGISKVLEntlDQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTArQGakfpikwTA----PE---AALYGRftiKSDVWSFGILQTELVTkGRVPYP---GMVNREVLEQVERG--YRMP 490
Cdd:cd06623 157 CNTF-VG-------TVtymsPEriqGESYSY---AADIWSLGLTLLECAL-GKFPFLppgQPSFFELMQAICDGppPSLP 224
                       250       260
                ....*....|....*....|....*.
gi 6678617  491 cPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd06623 225 -AEEFSPEFRDFISACLQKDPKKRPS 249
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
280-527 2.94e-29

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 116.89  E-value: 2.94e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-------IYIVTEF 348
Cdd:cd07840   6 QIGEGTYGQVYKARNKKTgELVALKKIRMENEkegFPITAIREIKLLQKLDHPNVVRLKEIVTSKGsakykgsIYMVFEY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKgsllDF--LKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLiedneYTA 426
Cdd:cd07840  86 MDH----DLtgLLDNPEVKFTESQIKCYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARP-----YTK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIK----W-TAPE----AALYGRftiKSDVWSFGILQTELVTkGRVPYPGmvnREVLEQVERGYRMpCPQGCPE 497
Cdd:cd07840 157 ENNADYTNRvitlWyRPPElllgATRYGP---EVDMWSVGCILAELFT-GKPIFQG---KTELEQLEKIFEL-CGSPTEE 228
                       250       260       270
                ....*....|....*....|....*....|
gi 6678617  498 SLHELMNLCWKKDPdeRPTFEYIQSFLEDY 527
Cdd:cd07840 229 NWPGVSDLPWFENL--KPKKPYKRRLREVF 256
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
271-516 3.72e-29

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 115.83  E-value: 3.72e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLkPGTMMPEAFLQEAQIMKKLRHDKLVPLYA-VVSEEPIYIVTEF 348
Cdd:cd06612   1 PEEVFDILEKLGEGSYGSVYKAIHKETGQvVAIKVV-PVEEDLQEIIKEISILKQCDSPYIVKYYGsYFKNTDLWIVMEY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ 428
Cdd:cd06612  80 CGAGSVSDIMKI-TNKTLTEEEIAAILYQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKLADFGVSGQLTDTMAKRNT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVErgyRMPcPQGC--PESLHELMN-- 504
Cdd:cd06612 159 VIGTPF-WMAPEVIQEIGYNNKADIWSLGITAIEM-AEGKPPYSDIHPMRAIFMIP---NKP-PPTLsdPEKWSPEFNdf 232
                       250
                ....*....|....
gi 6678617  505 --LCWKKDPDERPT 516
Cdd:cd06612 233 vkKCLVKDPEERPS 246
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
280-520 4.26e-29

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 115.41  E-value: 4.26e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPEAFLQEAQIMKKLR----HDKLVPLYAVVSEEP---IYIVTEFMSK 351
Cdd:cd05118   6 KIGEGAFGTVWLARDKVTgEKVAIKKIKNDFRHPKAALREIKLLKHLNdvegHPNIVKLLDVFEHRGgnhLCLVFELMGM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 gSLLDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-GENLICKIADFGLARLIEDNEYTARQGa 430
Cdd:cd05118  86 -NLYELIKD-YPRGLPLDLIKSYLYQLLQALDFLHSNGIIHRDLKPENILInLELGQLKLADFGLARSFTSPPYTPYVA- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 kfPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER--GyrmpcpqgcPESLHELMNLCW 507
Cdd:cd05118 163 --TRWYRAPEVLLgAKPYGSSIDIWSLGCILAELLT-GRPLFPGDSEVDQLAKIVRllG---------TPEALDLLSKML 230
                       250
                ....*....|...
gi 6678617  508 KKDPDERPTFEYI 520
Cdd:cd05118 231 KYDPAKRITASQA 243
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
299-516 8.18e-29

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 115.15  E-value: 8.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  299 KVAIKTL---KPGTMMPEAfLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEgdgkylKLPQLVDM 374
Cdd:cd06610  28 KVAIKRIdleKCQTSMDEL-RKEIQAMSQCNHPNVVSYYtSFVVGDELWLVMPLLSGGSLLDIMKS------SYPRGGLD 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  375 AAQIA-------DGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEyTARQGAKFPIK----WTAPEAAL 443
Cdd:cd06610 101 EAIIAtvlkevlKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVSASLATGG-DRTRKVRKTFVgtpcWMAPEVME 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  444 YGR-FTIKSDVWSFGILQTELVTkGRVPY---PGMvnrEVLeqvergyrMPCPQGCPESLH-------------ELMNLC 506
Cdd:cd06610 180 QVRgYDFKADIWSFGITAIELAT-GAAPYskyPPM---KVL--------MLTLQNDPPSLEtgadykkysksfrKMISLC 247
                       250
                ....*....|
gi 6678617  507 WKKDPDERPT 516
Cdd:cd06610 248 LQKDPSKRPT 257
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
280-518 1.20e-28

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 114.11  E-value: 1.20e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd14007   7 PLGKGKFGNVYLAREKKSgFIVALKVISKSQLqksgLEHQLRREIEIQSHLRHPNILRLYGYFeDKKRIYLILEYAPNGE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKegdgKYLKLPQlvDMAA----QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:cd14007  87 LYKELK----KQKRFDE--KEAAkyiyQLALALDYLHSKNIIHRDIKPENILLGSNGELKLADFGWSVHAPSNRRKTFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMpcPQGCPESLHELMNLCWK 508
Cdd:cd14007 161 T---LDYLPPEMVEGKEYDYKVDIWSLGVLCYELLV-GKPPFESKSHQETYKRIQNVdIKF--PSSVSPEAKDLISKLLQ 234
                       250
                ....*....|
gi 6678617  509 KDPDERPTFE 518
Cdd:cd14007 235 KDPSKRLSLE 244
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
280-465 1.28e-28

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 115.29  E-value: 1.28e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTkVAIKTLKP--GTMMPE---AFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGS 353
Cdd:cd14158  22 KLGEGGFGVVFKGYINDKN-VAVKKLAAmvDISTEDltkQFEQEIQVMAKCQHENLVELLGYSCDGPQLcLVYTYMPNGS 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKY-LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ---- 428
Cdd:cd14158 101 LLDRLACLNDTPpLSWHMRCKIAQGTANGINYLHENNHIHRDIKSANILLDETFVPKISDFGLARASEKFSQTIMTeriv 180
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6678617  429 GAKfpiKWTAPEaALYGRFTIKSDVWSFGILQTELVT 465
Cdd:cd14158 181 GTT---AYMAPE-ALRGEITPKSDIFSFGVVLLEIIT 213
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
277-522 3.24e-28

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 113.28  E-value: 3.24e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSK 351
Cdd:cd08529   4 ILNKLGKGSFGVVYKVVRKVDGRVyALKQIDISRMsrkMREEAIDEARVLSKLNSPYVIKYYdSFVDKGKLNIVMEYAEN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK 431
Cdd:cd08529  84 GDLHSLIKSQRGRPLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDTTNFAQTIVG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 511
Cdd:cd08529 164 TPY-YLSPELCEDKPYNEKSDVWALGCVLYELCT-GKHPFEAQNQGALILKIVRGKYPPISASYSQDLSQLIDSCLTKDY 241
                       250
                ....*....|..
gi 6678617  512 DERP-TFEYIQS 522
Cdd:cd08529 242 RQRPdTTELLRN 253
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
281-516 4.36e-28

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 113.03  E-value: 4.36e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTL----------------KPGTMMpEAFLQEAQIMKKLRHDKLVPLYAVV---SEE 340
Cdd:cd14008   1 LGRGSFGKVKLALDTETgQLYAIKIFnksrlrkrregkndrgKIKNAL-DDVRREIAIMKKLDHPNIVRLYEVIddpESD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE 420
Cdd:cd14008  80 KLYLVLEYCEGGPVMELDSGDRVPPLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSEMFE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 -DNEYTAR-QG--AkFpikwTAPEAALYGRFTI---KSDVWSFGI-LQTeLVTkGRVPYPGMVNREVLEQVERGYRMPCP 492
Cdd:cd14008 160 dGNDTLQKtAGtpA-F----LAPELCDGDSKTYsgkAADIWALGVtLYC-LVF-GRLPFNGDNILELYEAIQNQNDEFPI 232
                       250       260
                ....*....|....*....|....*
gi 6678617  493 QG-CPESLHELMNLCWKKDPDERPT 516
Cdd:cd14008 233 PPeLSPELKDLLRRMLEKDPEKRIT 257
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
273-516 1.74e-27

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 111.32  E-value: 1.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTkVAIKTLKP---GTMMPEAFLQEAQIMKkLRHDKLVPLYAVVS----EEPIYIV 345
Cdd:cd13979   3 EPLRLQEPLGSGGFGSVYKATYKGET-VAVKIVRRrrkNRASRQSFWAELNAAR-LRHENIVRVLAAETgtdfASLGLII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED-NEY 424
Cdd:cd13979  81 MEYCGNGTLQQLIYEGSEP-LPLAHRILISLDIARALRFCHSHGIVHLDVKPANILISEQGVCKLCDFGCSVKLGEgNEV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 -TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMvNREVLEQVErGYRM-PCPQGCPES---- 498
Cdd:cd13979 160 gTPRSHIGGTYTYRAPELLKGERVTPKADIYSFGITLWQMLT-RELPYAGL-RQHVLYAVV-AKDLrPDLSGLEDSefgq 236
                       250
                ....*....|....*....
gi 6678617  499 -LHELMNLCWKKDPDERPT 516
Cdd:cd13979 237 rLRSLISRCWSAQPAERPN 255
PTKc_Aatyk2 cd05086
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs ...
280-524 2.20e-27

Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk2 is a member of the Aatyk subfamily of proteins, which are receptor kinases containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk2 is also called lemur tyrosine kinase 2 (Lmtk2) or brain-enriched kinase (Brek). It is expressed at high levels in early postnatal brain, and has been shown to play a role in nerve growth factor (NGF) signaling. Studies with knockout mice reveal that Aatyk2 is essential for late stage spermatogenesis. Although it is classified as a PTK based on sequence similarity and the phylogenetic tree, Aatyk2 has been functionally characterized as a serine/threonine kinase. The Aatyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270669 [Multi-domain]  Cd Length: 271  Bit Score: 111.11  E-value: 2.20e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG---TWNGTTKVAIKTLKPGTMMPEA--FLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEFMSKGS 353
Cdd:cd05086   4 EIGNGWFGKVLLGeiyTGTSVARVVVKELKASANPKEQddFLQQGEPYYILQHPNILQcVGQCVEAIPYLLVFEFCDLGD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQLVD---MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGL--ARLIEDneYTARQ 428
Cdd:cd05086  84 LKTYLANQQEKLRGDSQIMLlqrMACEIAAGLAHMHKHNFLHSDLALRNCYLTSDLTVKVGDYGIgfSRYKED--YIETD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKF-PIKWTAPEaaLYGRF---------TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV--ERGYRMPCP---Q 493
Cdd:cd05086 162 DKKYaPLRWTAPE--LVTSFqdgllaaeqTKYSNIWSLGVTLWELFENAAQPYSDLSDREVLNHVikERQVKLFKPhleQ 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  494 GCPESLHELMNLCWKKdPDERPTFEYIQSFL 524
Cdd:cd05086 240 PYSDRWYEVLQFCWLS-PEKRPTAEEVHRLL 269
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
276-522 7.32e-27

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 109.40  E-value: 7.32e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEV--KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFL----QEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTE 347
Cdd:cd14073   2 RYELleTLGKGTYGKVKLAIERATGReVAIKSIKKDKIEDEQDMvrirREIEIMSSLNHPHIIRIYEVFeNKDKIVIVME 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDgkylklpQLVDMAA-----QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd14073  82 YASGGELYDYISERR-------RLPEREArrifrQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGLSNLYSKD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 E----------YTARQGAKfPIKWTAPEAalygrftiksDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMPC 491
Cdd:cd14073 155 KllqtfcgsplYASPEIVN-GTPYQGPEV----------DCWSLGVLLYTLVY-GTMPFDGSDFKRLVKQISSGdYREPT 222
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  492 PqgcPESLHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14073 223 Q---PSDASGLIRWMLTVNPKRRATIEDIAN 250
PTK_Jak_rpt1 cd05037
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak ...
281-520 1.34e-26

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. In the case of Jak2, the presumed pseudokinase (repeat 1) domain exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270633 [Multi-domain]  Cd Length: 259  Bit Score: 108.72  E-value: 1.34e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMG-------TWNGTTKVAIKTLKP-GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKG 352
Cdd:cd05037   7 LGQGTFTNIYDGilrevgdGRVQEVEVLLKVLDSdHRDISESFFETASLMSQISHKHLVKLYGVCVADENIMVQEYVRYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV------GENLICKIADFGLARLIEDNEYTA 426
Cdd:cd05037  87 PLDKYLRR-MGNNVPLSWKLQVAKQLASALHYLEDKKLIHGNVRGRNILLaregldGYPPFIKLSDPGVPITVLSREERV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RqgakfPIKWTAPEAA--LYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQgCPEsLHELMN 504
Cdd:cd05037 166 D-----RIPWIAPECLrnLQANLTIAADKWSFGTTLWEICSGGEEPLSALSSQEKLQFYEDQHQLPAPD-CAE-LAELIM 238
                       250
                ....*....|....*.
gi 6678617  505 LCWKKDPDERPTFEYI 520
Cdd:cd05037 239 QCWTYEPTKRPSFRAI 254
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
281-518 1.56e-26

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 108.59  E-value: 1.56e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLD 356
Cdd:cd06605   9 LGEGNGGVVSKVRHRPSGQImAVKVirLEIDEALQKQILRELDVLHKCNSPYIVGFYgAFYSEGDISICMEYMDGGSLDK 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGkyLKLPQLVDMAAQIADGMAYI-ERMNYIHRDLRAANILVGENLICKIADFGLA-RLIED--NEYTARQgakf 432
Cdd:cd06605  89 ILKEVGR--IPERILGKIAVAVVKGLIYLhEKHKIIHRDVKPSNILVNSRGQVKLCDFGVSgQLVDSlaKTFVGTR---- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 piKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYP---GMVNREVLEQVERGYRMPCPQ----GCPESLHELMNL 505
Cdd:cd06605 163 --SYMAPERISGGKYTVKSDIWSLGLSLVELAT-GRFPYPppnAKPSMMIFELLSYIVDEPPPLlpsgKFSPDFQDFVSQ 239
                       250
                ....*....|...
gi 6678617  506 CWKKDPDERPTFE 518
Cdd:cd06605 240 CLQKDPTERPSYK 252
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
281-526 2.27e-26

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 108.00  E-value: 2.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPLYAVVSEEP--IYIVTEFMSKGSL 354
Cdd:cd14064   1 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSdvdmFCREVSILCRLNHPCVIQFVGACLDDPsqFAIVTQYVSGGSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNY--IHRDLRAANILVGENLICKIADFGLARLI---EDNEYTARQG 429
Cdd:cd14064  80 FSLLHE-QKRVIDLQSKLIIAVDVAKGMEYLHNLTQpiIHRDLNSHNILLYEDGHAVVADFGESRFLqslDEDNMTKQPG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AkfpIKWTAPEA-ALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMvnREVLEQVERGY---RMPCPQGCPESLHELMNL 505
Cdd:cd14064 159 N---LRWMAPEVfTQCTRYSIKADVFSYALCLWELLT-GEIPFAHL--KPAAAAADMAYhhiRPPIGYSIPKPISSLLMR 232
                       250       260
                ....*....|....*....|.
gi 6678617  506 CWKKDPDERPTFEYIQSFLED 526
Cdd:cd14064 233 GWNAEPESRPSFVEIVALLEP 253
PK_ILK cd14057
Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to ...
280-525 3.02e-26

Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. ILK contains N-terminal ankyrin repeats, a Pleckstrin Homology (PH) domain, and a C-terminal pseudokinase domain. It is a component of the IPP (ILK/PINCH/Parvin) complex that couples beta integrins to the actin cytoskeleton, and plays important roles in cell adhesion, spreading, invasion, and migration. ILK was initially thought to be an active kinase despite the lack of key conserved residues because of in vitro studies showing that it can phosphorylate certain protein substrates. However, in vivo experiments in Caenorhabditis elegans, Drosophila melanogaster, and mice (ILK-null and knock-in) proved that ILK is not an active kinase. In addition to actin cytoskeleton regulation, ILK also influences the microtubule network and mitotic spindle orientation. The pseudokinase domain of ILK binds several adaptor proteins including the parvins and paxillin. The ILK subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270959 [Multi-domain]  Cd Length: 251  Bit Score: 107.57  E-value: 3.02e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKVAiKTLKPGTMMPEA---FLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLL 355
Cdd:cd14057   2 KINETHSGELWKGRWQGNDIVA-KILKVRDVTTRIsrdFNEEYPRLRIFSHPNVLPVLGACNSPPnLVVISQYMPYGSLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI--HRDLRAANILVGENLICKIAdfglarlIEDNEYTARQGAK-F 432
Cdd:cd14057  81 NVLHEGTGVVVDQSQAVKFALDIARGMAFLHTLEPLipRHHLNSKHVMIDEDMTARIN-------MADVKFSFQEPGKmY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWTAPEAALYGRFTIK---SDVWSFGILQTELVTKgRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd14057 154 NPAWMAPEALQKKPEDINrrsADMWSFAILLWELVTR-EVPFADLSNMEIGMKIAlEGLRVTIPPGISPHMCKLMKICMN 232
                       250
                ....*....|....*..
gi 6678617  509 KDPDERPTFEYIQSFLE 525
Cdd:cd14057 233 EDPGKRPKFDMIVPILE 249
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
281-516 3.10e-26

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 107.83  E-value: 3.10e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE------AFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKG 352
Cdd:cd06625   8 LGQGAFGQVYLCYDADTGReLAVKQVEIDPINTEaskevkALECEIQLLKNLQHERIVQYYGCLQDEkSLSIFMEYMPGG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEdneyTARQGA 430
Cdd:cd06625  88 SVKDEIK----AYGALTENVtrKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKRLQ----TICSST 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KF------PiKWTAPEAAL---YGRftiKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGYRMP-CPQGCPESLH 500
Cdd:cd06625 160 GMksvtgtP-YWMSPEVINgegYGR---KADIWSVGCTVVEMLTT-KPPWAEFEPMAAIFKIATQPTNPqLPPHVSEDAR 234
                       250
                ....*....|....*.
gi 6678617  501 ELMNLCWKKDPDERPT 516
Cdd:cd06625 235 DFLSLIFVRNKKQRPS 250
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
281-530 3.14e-26

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 108.11  E-value: 3.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAI--KTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14222   1 LGKGFFGQAIKVTHKATGKVMVmkELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLyKDKRLNLLTEFIEGGTLKDF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI-ED--------------- 421
Cdd:cd14222  81 LRADD--PFPWQQKVSFAKGIASGMAYLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLIvEEkkkpppdkpttkkrt 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 ---NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVtkGRV-PYPGMVNReVLE---QVERGYRMPCPQG 494
Cdd:cd14222 159 lrkNDRKKRYTVVGNPYWMAPEMLNGKSYDEKVDIFSFGIVLCEII--GQVyADPDCLPR-TLDfglNVRLFWEKFVPKD 235
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6678617  495 CPESLHELMNLCWKKDPDERPTFEYiqsfLEDYFTA 530
Cdd:cd14222 236 CPPAFFPLAAICCRLEPDSRPAFSK----LEDSFEA 267
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
281-526 3.96e-26

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 107.70  E-value: 3.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPGTMMPEA----------------------FLQEAQIMKKLRHDKLVPLYAVvS 338
Cdd:cd14000   2 LGDGGFGSVYRASYKGE-PVAVKIFNKHTSSNFAnvpadtmlrhlratdamknfrlLRQELTVLSHLHHPSIVYLLGI-G 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLICKIA 411
Cdd:cd14000  80 IHPLMLVLELAPLGSLDHLLQQDSRSFASLGRTLqqRIALQVADGLRYLHSAMIIYRDLKSHNVLVwtlypNSAIIIKIA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARliedneYTARQGAK----FPiKWTAPEAALYG-RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG 486
Cdd:cd14000 160 DYGISR------QCCRMGAKgsegTP-GFRAPEIARGNvIYNEKVDVFSFGMLLYEILS-GGAPMVGHLKFPNEFDIHGG 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6678617  487 YRMPCPQ---GCPESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14000 232 LRPPLKQyecAPWPEVEVLMKKCWKENPQQRPTAVTVVSILNS 274
SH3_Src cd12008
Src homology 3 domain of Src Protein Tyrosine Kinase; Src (or c-Src) is a cytoplasmic (or ...
94-148 4.11e-26

Src homology 3 domain of Src Protein Tyrosine Kinase; Src (or c-Src) is a cytoplasmic (or non-receptor) PTK and is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells, and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212941 [Multi-domain]  Cd Length: 56  Bit Score: 100.96  E-value: 4.11e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617   94 FVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNYVVPA 148
Cdd:cd12008   2 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPS 56
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
280-522 4.64e-26

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 107.19  E-value: 4.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVW---MGTWNgtTKVAIKTlkPGTMMPEA-----FLQEAQIMKKLRHDKLVPLYAVVSEePIYIVTEFMSK 351
Cdd:cd14025   3 KVGSGGFGQVYkvrHKHWK--TWLAIKC--PPSLHVDDsermeLLEEAKKMEMAKFRHILPVYGICSE-PVGLVMEYMET 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLARLIEDNEYT--AR 427
Cdd:cd14025  78 GSLEKLLAS---EPLPWELRFRIIHETAVGMNFLHCMKppLLHLDLKPANILLDAHYHVKISDFGLAKWNGLSHSHdlSR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILQTELVTKgRVPYPGMVN-REVLEQVERGYR---MPCPQGCPES--- 498
Cdd:cd14025 155 DGLRGTIAYLPPERFKEKNrcPDTKHDVYSFAIVIWGILTQ-KKPFAGENNiLHIMVKVVKGHRpslSPIPRQRPSEcqq 233
                       250       260
                ....*....|....*....|....
gi 6678617  499 LHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14025 234 MICLMKRCWDQDPRKRPTFQDITS 257
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
323-516 1.24e-25

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 105.90  E-value: 1.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  323 KKLRHDKLVPLYAVVSEEP-------IYIVTEFMSKGSLLDFLKEGDgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDL 395
Cdd:cd14012  53 KKLRHPNLVSYLAFSIERRgrsdgwkVYLLTEYAPGGSLSELLDSVG--SVPLDTARRWTLQLLEALEYLHRNGVVHKSL 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  396 RAANILVGENL---ICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKgrvpy 471
Cdd:cd14012 131 HAGNVLLDRDAgtgIVKLTDYSLGKTLLDMCSRGSLDEFKQTYWLPPELAQgSKSPTRKTDVWDLGLLFLQMLFG----- 205
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6678617  472 pgmvnREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14012 206 -----LDVLEKYTSPNPVLVSLDLSASLQDFLSKCLSLDPKKRPT 245
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
281-514 1.84e-25

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 105.29  E-value: 1.84e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd05123   1 LGKGSFGKVLLVRKKDTGKLyAMKVLRKKEIikrkEVEHTLNERNILERVNHPFIVKLhYAFQTEEKLYLVLDYVPGGEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdgKYLKLPQlvDM----AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNEYTarqg 429
Cdd:cd05123  81 FSHLS----KEGRFPE--ERarfyAAEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKeLSSDGDRT---- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 akfpikWT--------APEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGmVNREVLEQ--VERGYRMpcPQGCPESL 499
Cdd:cd05123 151 ------YTfcgtpeylAPEVLLGKGYGKAVDWWSLGVLLYEMLT-GKPPFYA-ENRKEIYEkiLKSPLKF--PEYVSPEA 220
                       250
                ....*....|....*
gi 6678617  500 HELMNLCWKKDPDER 514
Cdd:cd05123 221 KSLISGLLQKDPTKR 235
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
273-516 3.05e-25

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 105.02  E-value: 3.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLYA-VVSEEPIYIVTEF 348
Cdd:cd06609   1 ELFTLLERIGKGSFGEVYKGIDKRTNQvVAIKVidLEEAEDEIEDIQQEIQFLSQCDSPYITKYYGsFLKGSKLWIIMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEG--DGKYLKLpqlvdMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNeYTA 426
Cdd:cd06609  81 CGGGSVLDLLKPGplDETYIAF-----ILREVLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLADFGVSGQLTST-MSK 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQ---GAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYPGMVNREVLEQVErgyRMPCPQ----GCPESL 499
Cdd:cd06609 155 RNtfvGTPF---WMAPEVIKQSGYDEKADIWSLGITAIELA-KGEPPLSDLHPMRVLFLIP---KNNPPSlegnKFSKPF 227
                       250
                ....*....|....*..
gi 6678617  500 HELMNLCWKKDPDERPT 516
Cdd:cd06609 228 KDFVELCLNKDPKERPS 244
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
276-473 3.96e-25

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 104.87  E-value: 3.96e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEvKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMS 350
Cdd:cd07829   3 KLE-KLGEGTYGVVYKAKDKKTGEiVALKKIRLDNEeegIPSTALREISLLKELKHPNIVKLLDViHTENKLYLVFEYCD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KgSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTARq 428
Cdd:cd07829  82 Q-DLKKYLDKRPGP-LPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARAfgIPLRTYTHE- 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6678617  429 gakfpIK--W-TAPEAALYGRF-TIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd07829 159 -----VVtlWyRAPEILLGSKHySTAVDIWSVGCIFAELIT-GKPLFPG 201
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
276-466 3.99e-25

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 105.86  E-value: 3.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTL-----KPGtmMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-------- 341
Cdd:cd07866  11 EILGKLGEGTFGEVYKARQIKTgRVVALKKIlmhneKDG--FPITALREIKILKKLKHPNVVPLIDMAVERPdkskrkrg 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 -IYIVTEFMSkgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE 420
Cdd:cd07866  89 sVYMVTPYMD--HDLSGLLENPSVKLTESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLARPYD 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  421 DNEYTARQG-----AKFP----IKWTAPEAALYG--RFTIKSDVWSFGILQTELVTK 466
Cdd:cd07866 167 GPPPNPKGGggggtRKYTnlvvTRWYRPPELLLGerRYTTAVDIWGIGCVFAEMFTR 223
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
281-528 5.20e-25

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 104.17  E-value: 5.20e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSL 354
Cdd:cd14099   9 LGKGGFAKCYEVTDMSTGKVyAGKVVPKSSLtkpkQREKLKSEIKIHRSLKHPNIVKFHDCfEDEENVYILLELCSNGSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNEytarqgAKFP 433
Cdd:cd14099  89 MELLKRR--KALTEPEVRYFMRQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAARLEyDGE------RKKT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IKWT----APEaALYGR--FTIKSDVWSFG-ILQTELVtkGRVPYPGMVNREVLEQVERG-YRMPCPQGCPESLHELMNL 505
Cdd:cd14099 161 LCGTpnyiAPE-VLEKKkgHSFEVDIWSLGvILYTLLV--GKPPFETSDVKETYKRIKKNeYSFPSHLSISDEAKDLIRS 237
                       250       260
                ....*....|....*....|...
gi 6678617  506 CWKKDPDERPTfeyIQSFLEDYF 528
Cdd:cd14099 238 MLQPDPTKRPS---LDEILSHPF 257
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
276-516 5.26e-25

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 104.04  E-value: 5.26e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWM-----GTWNGTTKVaIKTLKPGTMMPEAFLQ---EAQIMKKLRHDKLVPLYA-VVSEEPIYIVT 346
Cdd:cd08222   3 RVVRKLGSGNFGTVYLvsdlkATADEELKV-LKEISVGELQPDETVDanrEAKLLSKLDHPAIVKFHDsFVEKESFCIVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKE--GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLIcKIADFGLARLIEDNEY 424
Cdd:cd08222  82 EYCEGGDLDDKISEykKSGTTIDENQILDWFIQLLLAVQYMHERRILHRDLKAKNIFLKNNVI-KVGDFGISRILMGTSD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd08222 161 LATTFTGTPY-YMSPEVLKHEGYNSKSDIWSLGCILYEMCCL-KHAFDGQNLLSVMYKIVEGETPSLPDKYSKELNAIYS 238
                       250
                ....*....|..
gi 6678617  505 LCWKKDPDERPT 516
Cdd:cd08222 239 RMLNKDPALRPS 250
PK_GC-2D cd14043
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain ...
289-520 6.59e-25

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-2D is allso called Retinal Guanylyl Cyclase 1 (RETGC-1) or Rod Outer Segment membrane Guanylate Cyclase (ROS-GC). It is found in the photoreceptors of the retina where it anchors the reciprocal feedback loop between calcium and cGMP, which regulates the dark, light, and recovery phases in phototransduction. It is also found in other sensory neurons and may be a universal transduction component that plays a role in the perception of all senses. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-2D subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270945 [Multi-domain]  Cd Length: 267  Bit Score: 104.03  E-value: 6.59e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  289 VWMGTWNGTTKVAIKtlkPGTMmpEAFLQeaqiMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKY-- 365
Cdd:cd14043  26 VWLKKFPGGSHTELR---PSTK--NVFSK----LRELRHENVNLFLGLFVDCGILaIVSEHCSRGSLEDLLRNDDMKLdw 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  366 -LKLPQLVDMAAqiadGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE---- 440
Cdd:cd14043  97 mFKSSLLLDLIK----GMRYLHHRGIVHGRLKSRNCVVDGRFVLKITDYGYNEILEAQNLPLPEPAPEELLWTAPEllrd 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  441 AALYGRFTIKSDVWSFGILQTELVTKGrVPYP--GMVNREVLEQVERgyrmPCP---------QGCPESLHeLMNLCWKK 509
Cdd:cd14043 173 PRLERRGTFPGDVFSFAIIMQEVIVRG-APYCmlGLSPEEIIEKVRS----PPPlcrpsvsmdQAPLECIQ-LMKQCWSE 246
                       250
                ....*....|.
gi 6678617  510 DPDERPTFEYI 520
Cdd:cd14043 247 APERRPTFDQI 257
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
280-528 1.14e-24

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 103.11  E-value: 1.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSL 354
Cdd:cd08225   7 KIGEGSFGKIYLAKAKSDSEHCVIKEIDLTKMPvkekEASKKEVILLAKMKHPNIVTFFASFQENgRLFIVMEYCDGGDL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN-LICKIADFGLARLIEDNEYTARQGAKFP 433
Cdd:cd08225  87 MKRINRQRGVLFSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNgMVAKLGDFGIARQLNDSMELAYTCVGTP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IkWTAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd08225 167 Y-YLSPEICQNRPYNNKTDIWSLGCVLYELCTL-KHPFEGNNLHQLVLKICQGYFAPISPNFSRDLRSLISQLFKVSPRD 244
                       250
                ....*....|....*
gi 6678617  514 RPTfeyIQSFLEDYF 528
Cdd:cd08225 245 RPS---ITSILKRPF 256
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
276-490 1.50e-24

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 102.60  E-value: 1.50e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd14072   3 RLLKTIGKGNFAKVKLARHVLTGReVAIKIIDKTQLNPsslQKLFREVRIMKILNHPNIVKLFEVIeTEKTLYLVMEYAS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFL--------KEGDGKYlklpqlvdmaAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLArliedN 422
Cdd:cd14072  83 GGEVFDYLvahgrmkeKEARAKF----------RQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS-----N 147
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  423 EYTArqGAKFPIKWTAPEAALYGRFTIKS------DVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP 490
Cdd:cd14072 148 EFTP--GNKLDTFCGSPPYAAPELFQGKKydgpevDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGkYRIP 219
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
271-516 2.09e-24

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 102.82  E-value: 2.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVT 346
Cdd:cd06640   2 PEELFTKLERIGKGSFGEVFKGIDNRTQQVvAIKIidLEEAEDEIEDIQQEITVLSQCDSPYVTKYYgSYLKGTKLWIIM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGDGKYLklpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06640  82 EYLGGGSALDLLRAGPFDEF---QIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd06640 159 NTFVGTPF-WMAPEVIQQSAYDSKADIWSLGITAIEL-AKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFSKPFKEFIDAC 236
                       250
                ....*....|
gi 6678617  507 WKKDPDERPT 516
Cdd:cd06640 237 LNKDPSFRPT 246
PTKc_Aatyk3 cd14206
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs ...
280-521 2.40e-24

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk3, also called lemur tyrosine kinase 3 (Lmtk3) is a receptor kinase containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. The function of Aatyk3 is still unknown. The Aatyk3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271108 [Multi-domain]  Cd Length: 276  Bit Score: 102.72  E-value: 2.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG---TWNGTTKVAIKTLK--PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGS 353
Cdd:cd14206   4 EIGNGWFGKVILGeifSDYTPAQVVVKELRvsAGPLEQRKFISEAQPYRSLQHPNILQCLGLCTETiPFLLIMEFCQLGD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLK---EGDGKYLKLP-----QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL-IEDNEY 424
Cdd:cd14206  84 LKRYLRaqrKADGMTPDLPtrdlrTLQRMAYEITLGLLHLHKNNYIHSDLALRNCLLTSDLTVRIGDYGLSHNnYKEDYY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPIKWTAPE--AALYGRFTI-----KSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQ---G 494
Cdd:cd14206 164 LTPDRLWIPLRWVAPEllDELHGNLIVvdqskESNVWSLGVTIWELFEFGAQPYRHLSDEEVLTFVVREQQMKLAKprlK 243
                       250       260
                ....*....|....*....|....*....
gi 6678617  495 CPES--LHELMNLCWKKdPDERPTFEYIQ 521
Cdd:cd14206 244 LPYAdyWYEIMQSCWLP-PSQRPSVEELH 271
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
271-516 2.94e-24

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 102.46  E-value: 2.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVT 346
Cdd:cd06641   2 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVvAIKIidLEEAEDEIEDIQQEITVLSQCDSPYVTKYYgSYLKDTKLWIIM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGDgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06641  82 EYLGGGSALDLLEPGP---LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd06641 159 N*FVGTPF-WMAPEVIKQSAYDSKADIWSLGITAIEL-ARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEAC 236
                       250
                ....*....|
gi 6678617  507 WKKDPDERPT 516
Cdd:cd06641 237 LNKEPSFRPT 246
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
281-526 3.05e-24

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 101.83  E-value: 3.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEFMSKGSLLDFLK 359
Cdd:cd14156   1 IGSGFFSKVYKVTHGATGKVMVVKIYKNDVDQHKIVREISLLQKLSHPNIVRyLGICVKDEKLHPILEYVSGGCLEELLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 EGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLIED------NEYTARQGA 430
Cdd:cd14156  81 REELP-LSWREKVELACDISRGMVYLHSKNIYHRDLNSKNCLIrvtPRGREAVVTDFGLAREVGEmpandpERKLSLVGS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtkGRVPypgmVNREVLEQVE------RGYRMPCPqGCPESLHELMN 504
Cdd:cd14156 160 AF---WMAPEMLRGEPYDRKVDVFSFGIVLCEIL--ARIP----ADPEVLPRTGdfgldvQAFKEMVP-GCPEPFLDLAA 229
                       250       260
                ....*....|....*....|..
gi 6678617  505 LCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14156 230 SCCRMDAFKRPSFAELLDELED 251
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
280-516 3.46e-24

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 101.99  E-value: 3.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMgTWNGTTKV--AIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSL 354
Cdd:cd13996  13 LLGSGGFGSVYK-VRNKVDGVtyAIKKirLTEKSSASEKVLREVKALAKLNHPNIVRYYtAWVEEPPLYIQMELCEGGTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDG-KYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-GENLICKIADFGLARLIE------------ 420
Cdd:cd13996  92 RDWIDRRNSsSKNDRKLALELFKQILKGVSYIHSKGIVHRDLKPSNIFLdNDDLQVKIGDFGLATSIGnqkrelnnlnnn 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 ----DNEYTARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtkgrvpYPGMVNRE---VLEQVERGYrmpcpq 493
Cdd:cd13996 172 nngnTSNNSVGIGTPL---YASPEQLDGENYNEKADIYSLGIILFEML------HPFKTAMErstILTDLRNGI------ 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  494 gCPESLHELMNlCWK--------KDPDERPT 516
Cdd:cd13996 237 -LPESFKAKHP-KEAdliqsllsKNPEERPS 265
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
276-522 3.66e-24

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 101.56  E-value: 3.66e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPEAFLQ----EAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFM 349
Cdd:cd14081   4 RLGKTLGKGQTGLVKLAKHCVTgQKVAIKIVNKEKLSKESVLMkverEIAIMKLIEHPNVLKLYDVYEnKKYLYLVLEYV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFL-KEGdgkylKLP--QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYtA 426
Cdd:cd14081  84 SGGELFDYLvKKG-----RLTekEARKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPEGSL-L 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPiKWTAPEA----ALYGRftiKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP--CPQGCPESL 499
Cdd:cd14081 158 ETSCGSP-HYACPEVikgeKYDGR---KADIWSCGVILYALLV-GALPFDDDNLRQLLEKVKRGvFHIPhfISPDAQDLL 232
                       250       260
                ....*....|....*....|...
gi 6678617  500 HELMnlcwKKDPDERPTFEYIQS 522
Cdd:cd14081 233 RRML----EVNPEKRITIEEIKK 251
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
281-516 3.86e-24

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 102.07  E-value: 3.86e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTwNGTTK--VAIKTLK-PGTM----------MPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVT 346
Cdd:cd06629   9 IGKGTYGRVYLAM-NATTGemLAVKQVElPKTSsdradsrqktVVDALKSEIDTLKDLDHPNIVQyLGFEETEDYFSIFL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKegdgKYLKL-PQLV-DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED--- 421
Cdd:cd06629  88 EYVPGGSIGSCLR----KYGKFeEDLVrFFTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGISKKSDDiyg 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 -NEYTARQGAKFpikWTAPEA-ALYGR-FTIKSDVWSFGILQTELVTkGRVPYPGMvnrevlEQVERGYRM-------PC 491
Cdd:cd06629 164 nNGATSMQGSVF---WMAPEViHSQGQgYSAKVDIWSLGCVVLEMLA-GRRPWSDD------EAIAAMFKLgnkrsapPV 233
                       250       260
                ....*....|....*....|....*...
gi 6678617  492 PQG---CPESlHELMNLCWKKDPDERPT 516
Cdd:cd06629 234 PEDvnlSPEA-LDFLNACFAIDPRDRPT 260
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
281-521 5.21e-24

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 101.22  E-value: 5.21e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNG-TTKVAIKTLKPgTMMPEAFLQ-----EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd14162   8 LGHGSYAVVKKAYSTKhKCKVAIKIVSK-KKAPEDYLQkflprEIEVIKGLKHPNLICFYEAIeTTSRVYIIMELAENGD 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARliedNEYTARQGAKFP 433
Cdd:cd14162  87 LLDYIRKN--GALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFAR----GVMKTKDGKPKL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IK-------WTAPE---AALYGRFTikSDVWSFG-ILQTELVtkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHEL 502
Cdd:cd14162 161 SEtycgsyaYASPEilrGIPYDPFL--SDIWSMGvVLYTMVY--GRLPFDDSNLKVLLKQVQRRVVFPKNPTVSEECKDL 236
                       250       260
                ....*....|....*....|.
gi 6678617  503 MN--LCWKKdpdERPTFEYIQ 521
Cdd:cd14162 237 ILrmLSPVK---KRITIEEIK 254
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
281-526 8.42e-24

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 101.03  E-value: 8.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLK-PGTMMPE-AFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDF 357
Cdd:cd14664   1 IGRGGAGTVYKGVMPNGTLVAVKRLKgEGTQGGDhGFQAEIQTLGMIRHRNIVRLRGYCSnPTTNLLVYEYMPNGSLGEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 L--KEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF 432
Cdd:cd14664  81 LhsRPESQPPLDWETRQRIALGSARGLAYLHHdcsPLIIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDSHVMSSVAG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR----------VPYPGMVNREVLEQVERGYRMPCPQGCPeSLHEL 502
Cdd:cd14664 161 SYGYIAPEYAYTGKVSEKSDVYSYGVVLLELITGKRpfdeaflddgVDIVDWVRGLLEEKKVEALVDPDLQGVY-KLEEV 239
                       250       260       270
                ....*....|....*....|....*....|
gi 6678617  503 MN------LCWKKDPDERPTFEYIQSFLED 526
Cdd:cd14664 240 EQvfqvalLCTQSSPMERPTMREVVRMLEG 269
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
274-521 1.14e-23

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 100.49  E-value: 1.14e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP-EAFLQEAQIMKKL-RHDKLVPLY--AVVSEEP---IYIV 345
Cdd:cd13985   1 RYQVTKQLGEGGFSYVYLAHDVNTGRrYALKRMYFNDEEQlRVAIKEIEIMKRLcGHPNIVQYYdsAILSSEGrkeVLLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFmSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLArLIEDNE 423
Cdd:cd13985  81 MEY-CPGSLVDILEKSPPSPLSEEEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNTGRFKLCDFGSA-TTEHYP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKFPI----KWT-----APEAA-LYGRFTI--KSDVWSFGILQTELVTKgRVPYPGmvnREVLEQVERGYRMPC 491
Cdd:cd13985 159 LERAEEVNIIEeeiqKNTtpmyrAPEMIdLYSKKPIgeKADIWALGCLLYKLCFF-KLPFDE---SSKLAIVAGKYSIPE 234
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  492 PQGCPESLHELMNLCWKKDPDERP-TFEYIQ 521
Cdd:cd13985 235 QPRYSPELHDLIRHMLTPDPAERPdIFQVIN 265
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
280-516 1.19e-23

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 100.45  E-value: 1.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQ---EAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSL 354
Cdd:cd06626   7 KIGEGTFGKVYTAVNLDTGELmAMKEIRFQDNDPKTIKEiadEMKVLEGLDHPNLVRYYGVeVHREEVYIFMEYCQEGTL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGkylkLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF 432
Cdd:cd06626  87 EELLRHGRI----LDEAVirVYTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAVKLKNNTTTMAPGEVN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWT----APEAALYGRFTIK---SDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVERGYRMPCPQGCPESL--HEL 502
Cdd:cd06626 163 SLVGTpaymAPEVITGNKGEGHgraADIWSLGCVVLEMAT-GKRPWSELDNEwAIMYHVGMGHKPPIPDSLQLSPegKDF 241
                       250
                ....*....|....
gi 6678617  503 MNLCWKKDPDERPT 516
Cdd:cd06626 242 LSRCLESDPKKRPT 255
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
281-517 1.22e-23

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 100.76  E-value: 1.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGT---WNgtTKVAIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKG 352
Cdd:cd14026   5 LSRGAFGTVSRARhadWR--VTVAIKCLKLDSPVGDSerncLLKEAEILHKARFSYILPILGICNEpEFLGIVTEYMTNG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDgKY--LKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ 428
Cdd:cd14026  83 SLNELLHEKD-IYpdVAWPLRLRILYEIALGVNYLHNMSppLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSISQSRS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFP----IKWTAPE---AALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVN-REVLEQVERGYRM-----PCPQGC 495
Cdd:cd14026 162 SKSAPeggtIIYMPPEeyePSQKRRASVKHDIYSYAIIMWEVLSR-KIPFEEVTNpLQIMYSVSQGHRPdtgedSLPVDI 240
                       250       260
                ....*....|....*....|....
gi 6678617  496 P--ESLHELMNLCWKKDPDERPTF 517
Cdd:cd14026 241 PhrATLINLIESGWAQNPDERPSF 264
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
281-522 1.28e-23

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 100.02  E-value: 1.28e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEV--WMGTWNgTTKVAIKTLK-------PGTmmPEAFLQEAQIMKKLRHDKLVPLYAVVSEE---PIYIVTEF 348
Cdd:cd14119   1 LGEGSYGKVkeVLDTET-LCRRAVKILKkrklrriPNG--EANVKREIQILRRLNHRNVIKLVDVLYNEekqKLYMVMEY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 mSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI----EDNEY 424
Cdd:cd14119  78 -CVGGLQEMLDSAPDKRLPIWQAHGYFVQLIDGLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEALdlfaEDDTC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAkfPiKWTAPE-AALYGRFT-IKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMpcPQGCPESLHE 501
Cdd:cd14119 157 TTSQGS--P-AFQPPEiANGQDSFSgFKVDIWSAGVTLYNMTT-GKYPFEGDNIYKLFENIGKGeYTI--PDDVDPDLQD 230
                       250       260
                ....*....|....*....|.
gi 6678617  502 LMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14119 231 LLRGMLEKDPEKRFTIEQIRQ 251
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
280-516 1.54e-23

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 100.52  E-value: 1.54e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd06642  11 RIGKGSFGEVYKGIDNRTKEVvAIKIidLEEAEDEIEDIQQEITVLSQCDSPYITRYYgSYLKGTKLWIIMEYLGGGSAL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIk 435
Cdd:cd06642  91 DLLKPGP---LEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 WTAPEAALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVergyrmpcPQGCPESLH--------ELMNLCW 507
Cdd:cd06642 167 WMAPEVIKQSAYDFKADIWSLGITAIEL-AKGEPPNSDLHPMRVLFLI--------PKNSPPTLEgqhskpfkEFVEACL 237

                ....*....
gi 6678617  508 KKDPDERPT 516
Cdd:cd06642 238 NKDPRFRPT 246
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
281-516 2.61e-23

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 99.26  E-value: 2.61e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKPGTMMpEAFLQEAQIMKKLRHDKLVPLYAVvSEEPIYIVTEFMSKGSLLDFLKE 360
Cdd:cd14068   2 LGDGGFGSVYRAVYRGE-DVAVKIFNKHTSF-RLLRQELVVLSHLHHPSLVALLAA-GTAPRMLVMELAPKGSLDALLQQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  361 GDGKYLKLPQLvDMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLICKIADFGLArliednEYTARQGAKF--- 432
Cdd:cd14068  79 DNASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLftlypNCAIIAKIADYGIA------QYCCRMGIKTseg 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIKWTAPEAA----LYGRftiKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCP---QGC---PEsLHEL 502
Cdd:cd14068 152 TPGFRAPEVArgnvIYNQ---QADVYSFGLLLYDILTCGERIVEGLKFPNEFDELAIQGKLPDPvkeYGCapwPG-VEAL 227
                       250
                ....*....|....
gi 6678617  503 MNLCWKKDPDERPT 516
Cdd:cd14068 228 IKDCLKENPQCRPT 241
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
277-520 2.62e-23

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 99.00  E-value: 2.62e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPgTMMPEAFLQ----EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd14071   4 IERTIGKGNFAVVKLARHRITkTEVAIKIIDK-SQLDEENLKkiyrEVQIMKMLNHPHIIKLYQVMeTKDMLYLVTEYAS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKEgDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd14071  83 NGEIFDYLAQ-HGR-MSEKEARKKFWQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPGELLKTWCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFPikWTAPEAALYGRFT-IKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP--CPQGCPESLHELMNLc 506
Cdd:cd14071 161 SPP--YAAPEVFEGKEYEgPQLDIWSLGVVLYVLVC-GALPFDGSTLQTLRDRVLSGrFRIPffMSTDCEHLIRRMLVL- 236
                       250
                ....*....|....
gi 6678617  507 wkkDPDERPTFEYI 520
Cdd:cd14071 237 ---DPSKRLTIEQI 247
SH2_ABL cd09935
Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins; ...
156-249 2.75e-23

Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins; ABL-family proteins are highly conserved tyrosine kinases. Each ABL protein contains an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity and is common among nonreceptor tyrosine kinases. Several types of posttranslational modifications control ABL catalytic activity, subcellular localization, and stability, with consequences for both cytoplasmic and nuclear ABL functions. Binding partners provide additional regulation of ABL catalytic activity, substrate specificity, and downstream signaling. By combining this cassette with actin-binding and -bundling domain, ABL proteins are capable of connecting phosphoregulation with actin-filament reorganization. Vertebrate paralogs, ABL1 and ABL2, have evolved to perform specialized functions. ABL1 includes nuclear localization signals and a DNA binding domain which is used to mediate DNA damage-repair functions, while ABL2 has additional binding capacity for actin and for microtubules to enhance its cytoskeletal remodeling functions. SH2 is involved in several autoinhibitory mechanism that constrain the enzymatic activity of the ABL-family kinases. In one mechanism SH2 and SH3 cradle the kinase domain while a cap sequence stabilizes the inactive conformation resulting in a locked inactive state. Another involves phosphatidylinositol 4,5-bisphosphate (PIP2) which binds the SH2 domain through residues normally required for phosphotyrosine binding in the linker segment between the SH2 and kinase domains. The SH2 domain contributes to ABL catalytic activity and target site specificity. It is thought that the ABL catalytic site and SH2 pocket have coevolved to recognize the same sequences. Recent work now supports a hierarchical processivity model in which the substrate target site most compatible with ABL kinase domain preferences is phosphorylated with greatest efficiency. If this site is compatible with the ABL SH2 domain specificity, it will then reposition and dock in the SH2 pocket. This mechanism also explains how ABL kinases phosphorylates poor targets on the same substrate if they are properly positioned and how relatively poor substrate proteins might be recruited to ABL through a complex with strong substrates that can also dock with the SH2 pocket. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198189  Cd Length: 94  Bit Score: 93.99  E-value: 2.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRdWDEVrgdnVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd09935   5 WYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQYSISLR-YDGR----VYHYRISEDSDGKVYVTQEHRFNTLAELV 77
                        90
                ....*....|....
gi 6678617  236 KHYTEHADGLCHKL 249
Cdd:cd09935  78 HHHSKNADGLITTL 91
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
275-528 3.02e-23

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 99.22  E-value: 3.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMG---------TWNgttkvAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV---VSEEPI 342
Cdd:cd13983   3 LKFNEVLGRGSFKTVYRAfdteegievAWN-----EIKLRKLPKAERQRFKQEIEILKSLKHPNIIKFYDSwesKSKKEV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKegDGKYLKLPQLVDMAAQIADGMAYIERMNY--IHRDLRAANILV-GENLICKIADFGLARLI 419
Cdd:cd13983  78 IFITELMTSGTLKQYLK--RFKRLKLKVIKSWCRQILEGLNYLHTRDPpiIHRDLKCDNIFInGNTGEVKIGDLGLATLL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EDNEYTARQGAkfPiKWTAPEaaLY-GRFTIKSDVWSFGILQTELVTkGRVPY-----PGMVNREVLEQVErgyrmpcpq 493
Cdd:cd13983 156 RQSFAKSVIGT--P-EFMAPE--MYeEHYDEKVDIYAFGMCLLEMAT-GEYPYsectnAAQIYKKVTSGIK--------- 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6678617  494 gcPESLH--------ELMNLCWKKdPDERPTfeyIQSFLEDYF 528
Cdd:cd13983 221 --PESLSkvkdpelkDFIEKCLKP-PDERPS---ARELLEHPF 257
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
281-516 7.85e-23

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 97.99  E-value: 7.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMG--TWNG---------TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEF 348
Cdd:cd06628   8 IGSGSFGSVYLGmnASSGelmavkqveLPSVSAENKDRKKSMLDALQREIALLRELQHENIVQyLGSSSDANHLNIFLEY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEgdgkYLKLPQ-LV-DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN---- 422
Cdd:cd06628  88 VPGGSVATLLNN----YGAFEEsLVrNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLEANslst 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 -EYTAR---QGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 498
Cdd:cd06628 164 kNNGARpslQGSVF---WMAPEVVKQTSYTRKADIWSLGCLVVEMLT-GTHPFPDCTQMQAIFKIGENASPTIPSNISSE 239
                       250
                ....*....|....*...
gi 6678617  499 LHELMNLCWKKDPDERPT 516
Cdd:cd06628 240 ARDFLEKTFEIDHNKRPT 257
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
281-516 7.94e-23

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 98.50  E-value: 7.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTtKVAIKTLKpgTMMPEAFLQEAQI--MKKLRHDKLVPLYA--VVSEEPI---YIVTEFMSKGS 353
Cdd:cd14056   3 IGKGRYGEVWLGKYRGE-KVAVKIFS--SRDEDSWFRETEIyqTVMLRHENILGFIAadIKSTGSWtqlWLITEYHEHGS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDgkyLKLPQLVDMAAQIADGMAYI--ERMNY------IHRDLRAANILVGENLICKIADFGLA------RLI 419
Cdd:cd14056  80 LYDYLQRNT---LDTEEALRLAYSAASGLAHLhtEIVGTqgkpaiAHRDLKSKNILVKRDGTCCIADLGLAvrydsdTNT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EDNEYTARQGAKfpiKWTAPEaALYGRFTIKS-------DVWSFGILQTELVTKGRV---------PYPGMVNRE-VLEQ 482
Cdd:cd14056 157 IDIPPNPRVGTK---RYMAPE-VLDDSINPKSfesfkmaDIYSFGLVLWEIARRCEIggiaeeyqlPYFGMVPSDpSFEE 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6678617  483 -----VERGYRMPCP---QGCPE--SLHELMNLCWKKDPDERPT 516
Cdd:cd14056 233 mrkvvCVEKLRPPIPnrwKSDPVlrSMVKLMQECWSENPHARLT 276
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
266-516 2.38e-22

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 97.12  E-value: 2.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPREslrlevkLGQGCFGEVWMgTWNGTTKV--AIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEEP- 341
Cdd:cd06611   5 DIWEIIGE-------LGDGAFGKVYK-AQHKETGLfaAAKIIQIESEEElEDFMVEIDILSECKHPNIVGLYEAYFYENk 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLlDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLied 421
Cdd:cd06611  77 LWILIEFCDGGAL-DSIMLELERGLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGVSAK--- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKF---PiKWTAPEAALYGRFT-----IKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGY--RMPC 491
Cdd:cd06611 153 NKSTLQKRDTFigtP-YWMAPEVVACETFKdnpydYKADIWSLGITLIEL-AQMEPPHHELNPMRVLLKILKSEppTLDQ 230
                       250       260
                ....*....|....*....|....*
gi 6678617  492 PQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd06611 231 PSKWSSSFNDFLKSCLVKDPDDRPT 255
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
280-541 3.01e-22

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 97.26  E-value: 3.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMmPEAF-------LQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMS 350
Cdd:cd07841   7 KLGEGTYAVVYKARDKETgRIVAIKKIKLGER-KEAKdginftaLREIKLLQELKHPNIIGLLDVFGHKSnINLVFEFME 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 ---KGSLLD---FLKEGDGKYLKLpqlvdmaaQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDN 422
Cdd:cd07841  86 tdlEKVIKDksiVLTPADIKSYML--------MTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARSFgsPNR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARQGAKFpikWTAPE----AALYGrFTIksDVWSFGILQTELVTkgRVPY-PGMVNrevLEQVERGYRM---PCPQG 494
Cdd:cd07841 158 KMTHQVVTRW---YRAPEllfgARHYG-VGV--DMWSVGCIFAELLL--RVPFlPGDSD---IDQLGKIFEAlgtPTEEN 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678617  495 CPE--SLH-------------------------ELMNLCWKKDPDERPTFEyiQSFLEDYFTaTEPQYQPGENL 541
Cdd:cd07841 227 WPGvtSLPdyvefkpfpptplkqifpaasddalDLLQRLLTLNPNKRITAR--QALEHPYFS-NDPAPTPPSQL 297
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
281-516 3.48e-22

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 96.01  E-value: 3.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM------GTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGS 353
Cdd:cd14098   8 LGSGTFAEVKKavevetGKMRAIKQIVKRKVAGNDKNLQLFQREINILKSLEHPGIVRLIDWYEDdQHIYLVMEYVEGGD 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGkylkLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGEN--LICKIADFGLARLIEDNEYTARQG 429
Cdd:cd14098  88 LMDFIMAWGA----IPEQHarELTKQILEAMAYTHSMGITHRDLKPENILITQDdpVIVKISDFGLAKVIHTGTFLVTFC 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKfpIKWTAPE------AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP-------CPQGc 495
Cdd:cd14098 164 GT--MAYLAPEilmskeQNLQGGYSNLVDMWSVGCLVYVMLT-GALPFDGSSQLPVEKRIRKGrYTQPplvdfniSEEA- 239
                       250       260
                ....*....|....*....|.
gi 6678617  496 peslHELMNLCWKKDPDERPT 516
Cdd:cd14098 240 ----IDFILRLLDVDPEKRMT 256
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
281-516 3.96e-22

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 96.13  E-value: 3.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE----AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSL 354
Cdd:cd05581   9 LGEGSYSTVVLAKEKETGKeYAIKVLDKRHIIKEkkvkYVTIEKEVLSRLAHPGIVKLYYTFqDESKLYFVLEYAPNGDL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdgKYLKLpqlvDM------AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL-------IED 421
Cdd:cd05581  89 LEYIR----KYGSL----DEkctrfyTAEIVLALEYLHSKGIIHRDLKPENILLDEDMHIKITDFGTAKVlgpdsspEST 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFPIK---------WTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV-ERGYRMPC 491
Cdd:cd05581 161 KGDADSQIAYNQARaasfvgtaeYVSPELLNEKPAGKSSDLWALGCIIYQMLT-GKPPFRGSNEYLTFQKIvKLEYEFPE 239
                       250       260
                ....*....|....*....|....*...
gi 6678617  492 pqGCPEslhELMNLCWK---KDPDERPT 516
Cdd:cd05581 240 --NFPP---DAKDLIQKllvLDPSKRLG 262
SH2 cd00173
Src homology 2 (SH2) domain; In general, SH2 domains are involved in signal transduction; they ...
155-238 5.49e-22

Src homology 2 (SH2) domain; In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. They are present in a wide array of proteins including: adaptor proteins (Nck1, Crk, Grb2), scaffolds (Slp76, Shc, Dapp1), kinases (Src, Syk, Fps, Tec), phosphatases (Shp-1, Shp-2), transcription factors (STAT1), Ras signaling molecules (Ras-Gap), ubiquitination factors (c-Cbl), cytoskeleton regulators (Tensin), signal regulators (SAP), and phospholipid second messengers (PLCgamma), amongst others.


Pssm-ID: 198173 [Multi-domain]  Cd Length: 79  Bit Score: 89.82  E-value: 5.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLnpGNQRGIFLVRESETTKGAYSLSIRdwdeVRGDNVKHYKIRKLDNGGYYI-TTRAQFDTLQK 233
Cdd:cd00173   1 PWFHGSISREEAERLLR--GKPDGTFLVRESSSEPGDYVLSVR----SGDGKVKHYLIERNEGGYYLLgGSGRTFPSLPE 74

                ....*
gi 6678617  234 LVKHY 238
Cdd:cd00173  75 LVEHY 79
PK_GC_unk cd14045
Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The ...
292-524 6.39e-22

Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270947 [Multi-domain]  Cd Length: 269  Bit Score: 95.70  E-value: 6.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  292 GTWNGTTkVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKyLKLP 369
Cdd:cd14045  26 GIYDGRT-VAIKKIAKKSFtLSKRIRKEVKQVRELDHPNLCKFIGGCIEVPnVAIITEYCPKGSLNDVLLNEDIP-LNWG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  370 QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA--RLIEDNEYTARQGAKFPIKWTAPEA--ALYG 445
Cdd:cd14045 104 FRFSFATDIARGMAYLHQHKIYHGRLKSSNCVIDDRWVCKIADYGLTtyRKEDGSENASGYQQRLMQVYLPPENhsNTDT 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  446 RFTIKSDVWSFGILQTELVTKGRvPYPgmvnrEVLEQVERGYRMP------------CPqgCPESLHELMNLCWKKDPDE 513
Cdd:cd14045 184 EPTQATDVYSYAIILLEIATRND-PVP-----EDDYSLDEAWCPPlpelisgktensCP--CPADYVELIRRCRKNNPAQ 255
                       250
                ....*....|.
gi 6678617  514 RPTFEYIQSFL 524
Cdd:cd14045 256 RPTFEQIKKTL 266
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
276-520 7.86e-22

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 94.94  E-value: 7.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGTT---KVAIKTLKPgTMMPEAFLQ-----EAQIMKKLRHDKLVPLYAVVSEEP-IYIVT 346
Cdd:cd14080   3 RLGKTIGEGSYSKVKLAEYTKSGlkeKVACKIIDK-KKAPKDFLEkflprELEILRKLRHPNIIQVYSIFERGSkVFIFM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGdGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY-- 424
Cdd:cd14080  82 EYAEHGDLLEYIQKR-GA-LSESQARIWFRQLALAVQYLHSLDIAHRDLKCENILLDSNNNVKLSDFGFARLCPDDDGdv 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 --------TArqgakfpikWTAPEaALYGRFTI--KSDVWSFGILQTELVTkGRVPY-----PGMVNRevleQVERGYRM 489
Cdd:cd14080 160 lsktfcgsAA---------YAAPE-ILQGIPYDpkKYDIWSLGVILYIMLC-GSMPFddsniKKMLKD----QQNRKVRF 224
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6678617  490 P-----CPQGCPESLHELMNlcwkKDPDERPTFEYI 520
Cdd:cd14080 225 PssvkkLSPECKDLIDQLLE----PDPTKRATIEEI 256
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
261-534 8.29e-22

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 96.65  E-value: 8.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  261 QGLAKDAWEIPRESLRLEvKLGQGCFGEVwMGTWNGTT--KVAIKTL-KPGTMMPEA--FLQEAQIMKKLRHDKLVPLYA 335
Cdd:cd07877   6 QELNKTIWEVPERYQNLS-PVGSGAYGSV-CAAFDTKTglRVAVKKLsRPFQSIIHAkrTYRELRLLKHMKHENVIGLLD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  336 VVS-----EE--PIYIVTEFMskGSLLDFLkegdgkyLKLPQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVG 403
Cdd:cd07877  84 VFTparslEEfnDVYLVTHLM--GADLNNI-------VKCQKLTDdhvqfLIYQILRGLKYIHSADIIHRDLKPSNLAVN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  404 ENLICKIADFGLARLIEDnEYTARQGAKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQ 482
Cdd:cd07877 155 EDCELKILDFGLARHTDD-EMTGYVATRW---YRAPEIMLnWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  483 VERgyrmpcPQGCPESlhELMnlcwKKDPDERPTfEYIQSF-------LEDYFTATEPQ 534
Cdd:cd07877 230 ILR------LVGTPGA--ELL----KKISSESAR-NYIQSLtqmpkmnFANVFIGANPL 275
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
273-516 1.25e-21

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 95.20  E-value: 1.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGcfgevwmgtwNGTTKVAIKTLKPGTMMPEA-------------FLQEAQIMKKLRHDKLVPLY-AVVS 338
Cdd:cd06620   5 QDLETLKDLGAG----------NGGSVSKVLHIPTGTIMAKKvihidakssvrkqILRELQILHECHSPYIVSFYgAFLN 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EEP-IYIVTEFMSKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYI-HRDLRAANILVGENLICKIADFGLA 416
Cdd:cd06620  75 ENNnIIICMEYMDCGSLDKILKKK--GPFPEEVLGKIAVAVLEGLTYLYNVHRIiHRDIKPSNILVNSKGQIKLCDFGVS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 R-LIEDNEYTARQGAKFpikwTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPG-----------MVNREVLEQV- 483
Cdd:cd06620 153 GeLINSIADTFVGTSTY----MSPERIQGGKYSVKSDVWSLGLSIIELAL-GEFPFAGsnddddgyngpMGILDLLQRIv 227
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  484 -ERGYRMPCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd06620 228 nEPPPRLPKDRIFPKDLRDFVDRCLLKDPRERPS 261
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
281-525 1.73e-21

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 93.69  E-value: 1.73e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLK 359
Cdd:cd14155   1 IGSGFFSEVYKVRHRTSGQVMALKMNTLSSNRANMLREVQLMNRLSHPNILRFMGVcVHQGQLHALTEYINGGNLEQLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  360 egDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLIED----NEYTARQGAKF 432
Cdd:cd14155  81 --SNEPLSWTVRVKLALDIARGLSYLHSKGIFHRDLTSKNCLIkrdENGYTAVVGDFGLAEKIPDysdgKEKLAVVGSPY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pikWTAPEAALYGRFTIKSDVWSFGILQTELVtkGRVPypgmVNREVLEQVER------GYRMPCPQgCPESLHELMNLC 506
Cdd:cd14155 159 ---WMAPEVLRGEPYNEKADVFSYGIILCEII--ARIQ----ADPDYLPRTEDfgldydAFQHMVGD-CPPDFLQLAFNC 228
                       250
                ....*....|....*....
gi 6678617  507 WKKDPDERPTFEYIQSFLE 525
Cdd:cd14155 229 CNMDPKSRPSFHDIVKTLE 247
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
280-518 2.15e-21

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 93.51  E-value: 2.15e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVW--MGTWNGTTKVAIK-----TLKPGTMmpEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSK 351
Cdd:cd14121   2 KLGSGTYATVYkaYRKSGAREVVAVKcvsksSLNKAST--ENLLTEIELLKKLKHPHIVELKDFQwDEEHIYLIMEYCSG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILV--GENLICKIADFGLARLIEDNEY-TA 426
Cdd:cd14121  80 GDLSRFIR----SRRTLPESTvrRFLQQLASALQFLREHNISHMDLKPQNLLLssRYNPVLKLADFGFAQHLKPNDEaHS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAkfPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV--ERGYRMPCPQGCPESLHELMN 504
Cdd:cd14121 156 LRGS--PL-YMAPEMILKKKYDARVDLWSVGVILYECLF-GRAPFASRSFEELEEKIrsSKPIEIPTRPELSADCRDLLL 231
                       250
                ....*....|....
gi 6678617  505 LCWKKDPDERPTFE 518
Cdd:cd14121 232 RLLQRDPDRRISFE 245
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
274-520 4.01e-21

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 92.83  E-value: 4.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGT--WNGTTKVAIKTLKP--GTMMPEAFLQEAQIMKKL-RHDKLVPLYAVVSE-EPIYIVTE 347
Cdd:cd13997   1 HFHELEQIGSGSFSEVFKVRskVDGCLYAVKKSKKPfrGPKERARALREVEAHAALgQHPNIVRYYSSWEEgGHLYIQME 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKE-GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE----DN 422
Cdd:cd13997  81 LCENGSLQDALEElSPISKLSEAEVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLEtsgdVE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARqgakfpikWTAPEA-ALYGRFTIKSDVWSFGILQTELVTKGRVPYpgmvNREVLEQVERGYRMPCPQ-GCPESLH 500
Cdd:cd13997 161 EGDSR--------YLAPELlNENYTHLPKADIFSLGVTVYEAATGEPLPR----NGQQWQQLRQGKLPLPPGlVLSQELT 228
                       250       260
                ....*....|....*....|
gi 6678617  501 ELMNLCWKKDPDERPTFEYI 520
Cdd:cd13997 229 RLLKVMLDPDPTRRPTADQL 248
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
280-518 4.88e-21

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 92.99  E-value: 4.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVwmgtwngtTKV---------AIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLY---AVVSEEPIYI 344
Cdd:cd08217   7 TIGKGSFGTV--------RKVrrksdgkilVWKEIDYGKMSEkekQQLVSEVNILRELKHPNIVRYYdriVDRANTTLYI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEG--DGKYLKLPQLVDMAAQIADGMAYIERMNY-----IHRDLRAANILVGENLICKIADFGLAR 417
Cdd:cd08217  79 VMEYCEGGDLAQLIKKCkkENQYIPEEFIWKIFTQLLLALYECHNRSVgggkiLHRDLKPANIFLDSDNNVKLGDFGLAR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  418 LIEDNEYTARQGAKFPIKWtAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPE 497
Cdd:cd08217 159 VLSHDSSFAKTYVGTPYYM-SPELLNEQSYDEKSDIWSLGCLIYELCA-LHPPFQAANQLELAKKIKEGKFPRIPSRYSS 236
                       250       260
                ....*....|....*....|.
gi 6678617  498 SLHELMNLCWKKDPDERPTFE 518
Cdd:cd08217 237 ELNEVIKSMLNVDPDKRPSVE 257
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
281-516 5.14e-21

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 92.88  E-value: 5.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAF------LQ-EAQIMKKLRHDKLVP-LYAVVSEEPIYIVTEFMSKG 352
Cdd:cd06631   9 LGKGAYGTVYCGLTSTGQLIAVKQVELDTSDKEKAekeyekLQeEVDLLKTLKHVNIVGyLGTCLEDNVVSIFMEFVPGG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ-- 428
Cdd:cd06631  89 SIASILA----RFGALEEPVfcRYTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAKRLCINLSSGSQsq 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 ------GAKFpikWTAPEAAL---YGRftiKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGyRMPCPQgCPESL 499
Cdd:cd06631 165 llksmrGTPY---WMAPEVINetgHGR---KSDIWSIGCTVFEMAT-GKPPWADMNPMAAIFAIGSG-RKPVPR-LPDKF 235
                       250       260
                ....*....|....*....|.
gi 6678617  500 ----HELMNLCWKKDPDERPT 516
Cdd:cd06631 236 speaRDFVHACLTRDQDERPS 256
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
281-522 6.78e-21

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 92.32  E-value: 6.78e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFL----QEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 355
Cdd:cd14161  11 LGKGTYGRVKKARDSSGRLVAIKSIRKDRIKDEQDLlhirREIEIMSSLNHPHIISVYEVFeNSSKIVIVMEYASRGDLY 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDgkylklpQLVDMAA-----QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd14161  91 DYISERQ-------RLSELEArhffrQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGLSNLYNQDKFLQTYCG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KfPIkWTAPEaALYGRFTI--KSDVWSFGILQTELVtKGRVPYPGMVNREVLEQVERG-YRMPCPqgcPESLHELMNLCW 507
Cdd:cd14161 164 S-PL-YASPE-IVNGRPYIgpEVDSWSLGVLLYILV-HGTMPFDGHDYKILVKQISSGaYREPTK---PSDACGLIRWLL 236
                       250
                ....*....|....*
gi 6678617  508 KKDPDERPTFEYIQS 522
Cdd:cd14161 237 MVNPERRATLEDVAS 251
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
280-516 7.33e-21

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 92.87  E-value: 7.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTL--KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGS 353
Cdd:cd06621   8 SLGEGAGGSVTKCRLRNTKTIfALKTIttDPNPDVQKQILRELEINKSCASPYIVKYYGAFLDEQdssIGIAMEYCEGGS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTArQGA 430
Cdd:cd06621  88 LDSIYKKVKKKGGRIGEKVlgKIAESVLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSgELVNSLAGTF-TGT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFpikWTAPEAALYGRFTIKSDVWSFGILQTElVTKGRVPYP--GMVNREVLEQVERGYRMPCPQ--GCP-------ESL 499
Cdd:cd06621 167 SY---YMAPERIQGGPYSITSDVWSLGLTLLE-VAQNRFPFPpeGEPPLGPIELLSYIVNMPNPElkDEPengikwsESF 242
                       250
                ....*....|....*..
gi 6678617  500 HELMNLCWKKDPDERPT 516
Cdd:cd06621 243 KDFIEKCLEKDGTRRPG 259
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
280-518 9.79e-21

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 91.60  E-value: 9.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTlkpgtmMPEAFLQEAQIMKKLR----------HDKLVPLYAVVSEEPI-YIVTE 347
Cdd:cd14050   8 KLGEGSFGEVFKVRSREDGKLyAVKR------SRSRFRGEKDRKRKLEeverheklgeHPNCVRFIKAWEEKGIlYIQTE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 fMSKGSLLDFLKEGDgkylKLPQ------LVDMAAqiadGMAYIERMNYIHRDLRAANILVGENLICKIADFGLarLIE- 420
Cdd:cd14050  82 -LCDTSLQQYCEETH----SLPEsevwniLLDLLK----GLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGL--VVEl 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 --DNEYTARQGAKfpiKWTAPEaALYGRFTIKSDVWSFGILQTELVTKGRVPypgmVNREVLEQVERGYrMP--CPQGCP 496
Cdd:cd14050 151 dkEDIHDAQEGDP---RYMAPE-LLQGSFTKAADIFSLGITILELACNLELP----SGGDGWHQLRQGY-LPeeFTAGLS 221
                       250       260
                ....*....|....*....|..
gi 6678617  497 ESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14050 222 PELRSIIKLMMDPDPERRPTAE 243
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
280-528 1.16e-20

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 92.38  E-value: 1.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKgSL 354
Cdd:cd07833   8 VVGEGAYGVVLKCRNKATGEiVAIKKFKeseDDEDVKKTALREVKVLRQLRHENIVNLKeAFRRKGRLYLVFEYVER-TL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEgdgkylkLPQLVDMAA------QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN------ 422
Cdd:cd07833  87 LELLEA-------SPGGLPPDAvrsyiwQLLQAIAYCHSHNIIHRDIKPENILVSESGVLKLCDFGFARALTARpasplt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTArqgakfpIKW-TAPEAAL----YGRftiKSDVWSFGILQTELVTkGRVPYPG--------------------MVNR 477
Cdd:cd07833 160 DYVA-------TRWyRAPELLVgdtnYGK---PVDVWAIGCIMAELLD-GEPLFPGdsdidqlyliqkclgplppsHQEL 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  478 EVLEQVERGYRMPcPQGCPESLH------------ELMNLCWKKDPDERPTFEyiQSFLEDYF 528
Cdd:cd07833 229 FSSNPRFAGVAFP-EPSQPESLErrypgkvsspalDFLKACLRMDPKERLTCD--ELLQHPYF 288
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
282-471 1.41e-20

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 91.16  E-value: 1.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  282 GQGCFGEVWMGTWNGTTK-VAIK-TLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFmSKGSLLD 356
Cdd:cd14002  10 GEGSFGKVYKGRRKYTGQvVALKfIPKRGKSEKElrNLRQEIEILRKLNHPNIIEMLdSFETKKEFVVVTEY-AQGELFQ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLkEGDGKylkLP--QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQgakfpI 434
Cdd:cd14002  89 IL-EDDGT---LPeeEVRSIAKQLVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCNTLVLTS-----I 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6678617  435 KWT----APEAALYGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd14002 160 KGTplymAPELVQEQPYDHTADLWSLGCILYELFV-GQPPF 199
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
279-474 1.69e-20

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 92.43  E-value: 1.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  279 VKLGQGCFGEVWMGTWNGTTK-VAIKTL-----KPGtmMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP---------IY 343
Cdd:cd07865  18 AKIGQGTFGEVFKARHRKTGQiVALKKVlmeneKEG--FPITALREIKILQLLKHENVVNLIEICRTKAtpynrykgsIY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMSKgSLLDFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI---- 419
Cdd:cd07865  96 LVFEFCEH-DLAGLLSNKNVKF-TLSEIKKVMKMLLNGLYYIHRNKILHRDMKAANILITKDGVLKLADFGLARAFslak 173
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678617  420 --EDNEYTARQgakFPIKWTAPEAAL----YGRftiKSDVWSFGILQTELVTKgrvpYPGM 474
Cdd:cd07865 174 nsQPNRYTNRV---VTLWYRPPELLLgerdYGP---PIDMWGAGCIMAEMWTR----SPIM 224
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
278-514 1.90e-20

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 91.62  E-value: 1.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  278 EVKLGqGCFGEVWMGTWNGTTkVAIKtlkpgtMMPE----AFLQEAQIMK--KLRHDKLVPLYAV----VSEEPIY-IVT 346
Cdd:cd14053   1 EIKAR-GRFGAVWKAQYLNRL-VAVK------IFPLqekqSWLTEREIYSlpGMKHENILQFIGAekhgESLEAEYwLIT 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKegdGKYLKLPQLVDMAAQIADGMAYI--ERMNY--------IHRDLRAANILVGENLICKIADFGLA 416
Cdd:cd14053  73 EFHERGSLCDYLK---GNVISWNELCKIAESMARGLAYLheDIPATngghkpsiAHRDFKSKNVLLKSDLTACIADFGLA 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLIEDNEYTARQ----GAKfpiKWTAPEaALYG--RFTIKS----DVWSFGILQTELVTKG----------RVPY----- 471
Cdd:cd14053 150 LKFEPGKSCGDThgqvGTR---RYMAPE-VLEGaiNFTRDAflriDMYAMGLVLWELLSRCsvhdgpvdeyQLPFeeevg 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  472 --PGM--VNREVLEQVERgyrmpcPQGCPESL-HELMNL-------CWKKDPDER 514
Cdd:cd14053 226 qhPTLedMQECVVHKKLR------PQIRDEWRkHPGLAQlcetieeCWDHDAEAR 274
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
300-473 1.90e-20

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 94.86  E-value: 1.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   300 VAIKTLKPgTMM--PEA---FLQEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFMsKGSLL-DFLKEGdGKyLKLPQLV 372
Cdd:NF033483  35 VAVKVLRP-DLArdPEFvarFRREAQSAASLSHPNIVSVYDVGEDGGIpYIVMEYV-DGRTLkDYIREH-GP-LSPEEAV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   373 DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIedNEYTARQGAKfpIKWTA----PEAALYGRFT 448
Cdd:NF033483 111 EIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARAL--SSTTMTQTNS--VLGTVhylsPEQARGGTVD 186
                        170       180
                 ....*....|....*....|....*
gi 6678617   449 IKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:NF033483 187 ARSDIYSLGIVLYEMLT-GRPPFDG 210
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
276-471 2.34e-20

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 90.79  E-value: 2.34e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPLYAVVsEEP--IYIVTEF 348
Cdd:cd14079   5 ILGKTLGVGSFGKVKLAEHELTgHKVAVKILNRQKIksldMEEKIRREIQILKLFRHPHIIRLYEVI-ETPtdIFMVMEY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEgDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTaRQ 428
Cdd:cd14079  84 VSGGELFDYIVQ-KGR-LSEDEARRFFQQIISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGLSNIMRDGEFL-KT 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  429 GAKFPiKWTAPE---AALYGRFTIksDVWSFG-ILQTELVtkGRVPY 471
Cdd:cd14079 161 SCGSP-NYAAPEvisGKLYAGPEV--DVWSCGvILYALLC--GSLPF 202
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
282-514 2.35e-20

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 90.78  E-value: 2.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  282 GQGCFGEVWMGTWNGTTKV-AIKTlkpgtMMPEA---------FLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVtefms 350
Cdd:cd05578   9 GKGSFGKVCIVQKKDTKKMfAMKY-----MNKQKciekdsvrnVLNELEILQELEHPFLVNLwYSFQDEEDMYMV----- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 kgslLDFLKEGDGKYlKLPQLVDM--------AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd05578  79 ----VDLLLGGDLRY-HLQQKVKFseetvkfyICEIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EY-TARQGAKfpiKWTAPE---AALYGrftIKSDVWSFGILQTELVTkGRVPYPGMVN--REVLEQVERGYRMPCPQGCP 496
Cdd:cd05578 154 TLaTSTSGTK---PYMAPEvfmRAGYS---FAVDWWSLGVTAYEMLR-GKRPYEIHSRtsIEEIRAKFETASVLYPAGWS 226
                       250
                ....*....|....*...
gi 6678617  497 ESLHELMNLCWKKDPDER 514
Cdd:cd05578 227 EEAIDLINKLLERDPQKR 244
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
281-462 2.69e-20

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 90.94  E-value: 2.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-NGTTKV-AIKTLKPGTMMP---EAFLQEAQIMKKLR---HDKLVPLYAVVSEEP-IYIVTEFMSK 351
Cdd:cd14052   8 IGSGEFSQVYKVSErVPTGKVyAVKKLKPNYAGAkdrLRRLEEVSILRELTldgHDNIVQLIDSWEYHGhLYIQTELCEN 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKE-GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd14052  88 GSLDVFLSElGLLGRLDEFRVWKILVELSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGMATVWPLIRGIEREGD 167
                       170       180       190
                ....*....|....*....|....*....|..
gi 6678617  431 KfpiKWTAPEAALYGRFTIKSDVWSFGILQTE 462
Cdd:cd14052 168 R---EYIAPEILSEHMYDKPADIFSLGLILLE 196
SH2_csk_like cd09937
Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk); Both the C-terminal ...
156-257 3.15e-20

Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk); Both the C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are members of the CSK-family of protein tyrosine kinases. These proteins suppress activity of Src-family kinases (SFK) by selectively phosphorylating the conserved C-terminal tail regulatory tyrosine by a similar mechanism. CHK is also capable of inhibiting SFKs by a non-catalytic mechanism that involves binding of CHK to SFKs to form stable protein complexes. The unphosphorylated form of SFKs is inhibited by CSK and CHK by a two-step mechanism. The first step involves the formation of a complex of SFKs with CSK/CHK with the SFKs in the complex are inactive. The second step, involves the phosphorylation of the C-terminal tail tyrosine of SFKs, which then dissociates and adopt an inactive conformation. The structural basis of how the phosphorylated SFKs dissociate from CSK/CHK to adopt the inactive conformation is not known. The inactive conformation of SFKs is stabilized by two intramolecular inhibitory interactions: (a) the pYT:SH2 interaction in which the phosphorylated C-terminal tail tyrosine (YT) binds to the SH2 domain, and (b) the linker:SH3 interaction of which the SH2-kinase domain linker binds to the SH3 domain. SFKs are activated by multiple mechanisms including binding of the ligands to the SH2 and SH3 domains to displace the two inhibitory intramolecular interactions, autophosphorylation, and dephosphorylation of YT. By selective phosphorylation and the non-catalytic inhibitory mechanism CSK and CHK are able to inhibit the active forms of SFKs. CSK and CHK are regulated by phosphorylation and inter-domain interactions. They both contain SH3, SH2, and kinase domains separated by the SH3-SH2 connector and SH2 kinase linker, intervening segments separating the three domains. They lack a conserved tyrosine phosphorylation site in the kinase domain and the C-terminal tail regulatory tyrosine phosphorylation site. The CSK SH2 domain is crucial for stabilizing the kinase domain in the active conformation. A disulfide bond here regulates CSK kinase activity. The subcellular localization and activity of CSK are regulated by its SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198190  Cd Length: 98  Bit Score: 85.42  E-value: 3.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRdwdevRGDNVKHYKIRKLdNGGYYITTRAQFDTLQKLV 235
Cdd:cd09937   5 WFHGKISREEAERLLQPPED--GLFLVRESTNYPGDYTLCVS-----FEGKVEHYRVIYR-NGKLTIDEEEYFENLIQLV 76
                        90       100
                ....*....|....*....|..
gi 6678617  236 KHYTEHADGLCHKLTTvcPTVK 257
Cdd:cd09937  77 EHYTKDADGLCTRLVK--PKVK 96
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
280-516 4.45e-20

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 90.02  E-value: 4.45e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGE-VWMGTWNGTtKVAIKTlkpgtMMPEAFLQEAQIMKKLR----HDKLVPLYAV-VSEEPIYIVTEFmSKGS 353
Cdd:cd13982   8 VLGYGSEGTiVFRGTFDGR-PVAVKR-----LLPEFFDFADREVQLLResdeHPNVIRYFCTeKDRQFLYIALEL-CAAS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKL---PQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLICKIADFGLARLIEDNEYT 425
Cdd:cd13982  81 LQDLVESPRESKLFLrpgLEPVRLLRQIASGLAHLHSLNIVHRDLKPQNILIstpnaHGNVRAMISDFGLCKKLDVGRSS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 --ARQGAKFPIKWTAPE---AALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVleQVERG-YRMPCPQG---CP 496
Cdd:cd13982 161 fsRRSGVAGTSGWIAPEmlsGSTKRRQTRAVDIFSLGCVFYYVLSGGSHPFGDKLEREA--NILKGkYSLDKLLSlgeHG 238
                       250       260
                ....*....|....*....|
gi 6678617  497 ESLHELMNLCWKKDPDERPT 516
Cdd:cd13982 239 PEAQDLIERMIDFDPEKRPS 258
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
281-497 4.92e-20

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 90.63  E-value: 4.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTL-----KPGtmMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-----------EPIY 343
Cdd:cd07864  15 IGEGTYGQVYKAKDKDTGElVALKKVrldneKEG--FPITAIREIKILRQLNHRSVVNLKEIVTDkqdaldfkkdkGAFY 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMS-------KGSLLDFLKEGDGKYLKlpqlvdmaaQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA 416
Cdd:cd07864  93 LVFEYMDhdlmgllESGLVHFSEDHIKSFMK---------QLLEGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLIEDNE---YTarqgAKFPIKWTAPEAALYG--RFTIKSDVWSFGILQTELVTKgRVPYPGmvNREV--LEQVERGYRM 489
Cdd:cd07864 164 RLYNSEEsrpYT----NKVITLWYRPPELLLGeeRYGPAIDVWSCGCILGELFTK-KPIFQA--NQELaqLELISRLCGS 236

                ....*...
gi 6678617  490 PCPQGCPE 497
Cdd:cd07864 237 PCPAVWPD 244
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
281-518 5.04e-20

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 89.82  E-value: 5.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTL----KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFM--SKG 352
Cdd:cd06607   9 IGHGSFGAVYYARNKRTSEvVAIKKMsysgKQSTEKWQDIIKEVKFLRQLRHPNTIEYKGCyLREHTAWLVMEYClgSAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdgkylKLPQLVDMAA---QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED-NEYTarq 428
Cdd:cd06607  89 DIVEVHK-------KPLQEVEIAAichGALQGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSASLVCPaNSFV--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFpikWTAPEAALY---GRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGyRMPCPQGCP--ESLHELM 503
Cdd:cd06607 159 GTPY---WMAPEVILAmdeGQYDGKVDVWSLGITCIELAER-KPPLFNMNAMSALYHIAQN-DSPTLSSGEwsDDFRNFV 233
                       250
                ....*....|....*
gi 6678617  504 NLCWKKDPDERPTFE 518
Cdd:cd06607 234 DSCLQKIPQDRPSAE 248
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
280-516 5.21e-20

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 89.76  E-value: 5.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSL 354
Cdd:cd08530   7 KLGKGSYGSVYKVKRLSDNQVyALKEVNLGSLSQkerEDSVNEIRLLASVNHPNIIRYKeAFLDGNRLCIVMEYAPFGDL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYLKLPQlvDM----AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd08530  87 SKLISKRKKKRRLFPE--DDiwriFIQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKVLKKNLAKTQIGT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 510
Cdd:cd08530 165 PL---YAAPEVWKGRPYDYKSDIWSLGCLLYEMAT-FRPPFEARTMQELRYKVCRGKFPPIPPVYSQDLQQIIRSLLQVN 240

                ....*.
gi 6678617  511 PDERPT 516
Cdd:cd08530 241 PKKRPS 246
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
277-520 6.95e-20

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 89.25  E-value: 6.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMG--TWNGTTkVAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLVPLYA-VVSEEPIYIVTEFM 349
Cdd:cd08224   4 IEKKIGKGQFSVVYRArcLLDGRL-VALKKVQIFEMMDakarQDCLKEIDLLQQLNHPNIIKYLAsFIENNELNIVLELA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKE--GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTAR 427
Cdd:cd08224  83 DAGDLSRLIKHfkKQKRLIPERTIWKYFVQLCSALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLGRFFSSKTTAAH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPY--PGMVNREVLEQVERGYRMPCPQGC-PESLHELMN 504
Cdd:cd08224 163 SLVGTPY-YMSPERIREQGYDFKSDIWSLGCLLYEMAAL-QSPFygEKMNLYSLCKKIEKCEYPPLPADLySQELRDLVA 240
                       250
                ....*....|....*.
gi 6678617  505 LCWKKDPDERPTFEYI 520
Cdd:cd08224 241 ACIQPDPEKRPDISYV 256
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
280-516 8.63e-20

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 88.90  E-value: 8.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLK--PGTMMpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd06613   7 RIGSGTYGDVYKARNIATGElAAVKVIKlePGDDF-EIIQQEISMLKECRHPNIVAYFgSYLRRDKLWIVMEYCGGGSLQ 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDNEYTARQ---GAKF 432
Cdd:cd06613  86 DIYQVTGP--LSELQIAYVCRETLKGLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQL-TATIAKRKsfiGTPY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pikWTAPEAAL---YGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGYRMP---------CPQgcpesLH 500
Cdd:cd06613 163 ---WMAPEVAAverKGGYDGKCDIWALGITAIEL-AELQPPMFDLHPMRALFLIPKSNFDPpklkdkekwSPD-----FH 233
                       250
                ....*....|....*.
gi 6678617  501 ELMNLCWKKDPDERPT 516
Cdd:cd06613 234 DFIKKCLTKNPKKRPT 249
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
261-473 9.14e-20

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 90.82  E-value: 9.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  261 QGLAKDAWEIPRESLRLEVkLGQGCFGEVWMGTWNGT-TKVAIKTL-KP--GTMMPEAFLQEAQIMKKLRHDKLVPLYAV 336
Cdd:cd07851   4 QELNKTVWEVPDRYQNLSP-VGSGAYGQVCSAFDTKTgRKVAIKKLsRPfqSAIHAKRTYRELRLLKHMKHENVIGLLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSE-------EPIYIVTEFMskGSLLdflkegdGKYLKLPQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVGE 404
Cdd:cd07851  83 FTPassledfQDVYLVTHLM--GADL-------NNIVKCQKLSDdhiqfLVYQILRGLKYIHSAGIIHRDLKPSNLAVNE 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  405 NLICKIADFGLARLIED--NEYTArqgakfpIKW-TAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd07851 154 DCELKILDFGLARHTDDemTGYVA-------TRWyRAPEIMLnWMHYNQTVDIWSVGCIMAELLT-GKTLFPG 218
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
282-516 1.04e-19

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 89.42  E-value: 1.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  282 GQGCFGEVWMGTWNGTTkVAIKTLKPGTMmpEAFLQEAQIMKK--LRHDKLVPLyaVVSEE-------PIYIVTEFMSKG 352
Cdd:cd13998   4 GKGRFGEVWKASLKNEP-VAVKIFSSRDK--QSWFREKEIYRTpmLKHENILQF--IAADErdtalrtELWLVTAFHPNG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIE---------RMNYIHRDLRAANILVGENLICKIADFGLA------R 417
Cdd:cd13998  79 SL*DYLS---LHTIDWVSLCRLALSVARGLAHLHseipgctqgKPAIAHRDLKSKNILVKNDGTCCIADFGLAvrlspsT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  418 LIEDNEYTARQGAKfpiKWTAPEaALYGRFTI-------KSDVWSFGILQTEL-----VTKGRV-----PYPGMV-NREV 479
Cdd:cd13998 156 GEEDNANNGQVGTK---RYMAPE-VLEGAINLrdfesfkRVDIYAMGLVLWEMasrctDLFGIVeeykpPFYSEVpNHPS 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  480 LEQ-----VERGYRMPCPQG---CPE--SLHELMNLCWKKDPDERPT 516
Cdd:cd13998 232 FEDmqevvVRDKQRPNIPNRwlsHPGlqSLAETIEECWDHDAEARLT 278
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
274-523 1.36e-19

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 88.93  E-value: 1.36e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGTWN-GTTKVAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTE 347
Cdd:cd08228   3 NFQIEKKIGRGQFSEVYRATCLlDRKPVALKKVQIFEMMDakarQDCVKEIDLLKQLNHPNVIKyLDSFIEDNELNIVLE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEGDGKYLKLPQ--LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYT 425
Cdd:cd08228  83 LADAGDLSQMIKYFKKQKRLIPErtVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVL-EQVERGYRMPCP-QGCPESLHELM 503
Cdd:cd08228 163 AHSLVGTPY-YMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLcQKIEQCDYPPLPtEHYSEKLRELV 241
                       250       260
                ....*....|....*....|
gi 6678617  504 NLCWKKDPDERPTFEYIQSF 523
Cdd:cd08228 242 SMCIYPDPDQRPDIGYVHQI 261
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
280-516 1.55e-19

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 89.07  E-value: 1.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTtKVAIKTLKpgTMMPEAFLQEAQIMKK--LRHDKLVPLYAVV-----SEEPIYIVTEFMSKG 352
Cdd:cd14144   2 SVGKGRYGEVWKGKWRGE-KVAVKIFF--TTEEASWFRETEIYQTvlMRHENILGFIAADikgtgSWTQLYLITDYHENG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIERMNY--------IHRDLRAANILVGENLICKIADFGLA-RLI-EDN 422
Cdd:cd14144  79 SLYDFLR---GNTLDTQSMLKLAYSAACGLAHLHTEIFgtqgkpaiAHRDIKSKNILVKKNGTCCIADLGLAvKFIsETN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EY----TARQGAKfpiKWTAPE----AALYGRFT--IKSDVWSFGILQTEL----VTKG-----RVPYPGMVN------- 476
Cdd:cd14144 156 EVdlppNTRVGTK---RYMAPEvldeSLNRNHFDayKMADMYSFGLVLWEIarrcISGGiveeyQLPYYDAVPsdpsyed 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  477 -REVLeqVERGYRMPCPQ-----GCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14144 233 mRRVV--CVERRRPSIPNrwssdEVLRTMSKLMSECWAHNPAARLT 276
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
281-486 2.16e-19

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 87.71  E-value: 2.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI-VTEFMSKGSLLDFL 358
Cdd:cd14006   1 LGRGRFGVVKRCIEKATGReFAAKFIPKRDKKKEAVLREISILNQLQHPRIIQLHEAYESPTELVlILELCSGGELLDRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  359 KEgDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLIcKIADFGLARLIEDNEYTarqgakFPIK 435
Cdd:cd14006  81 AE-RGSLSE-EEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLadrPSPQI-KIIDFGLARKLNPGEEL------KEIF 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  436 WT----APEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG 486
Cdd:cd14006 152 GTpefvAPEIVNGEPVSLATDMWSIGVLTYVLLS-GLSPFLGEDDQETLANISAC 205
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
280-524 2.24e-19

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 88.56  E-value: 2.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTtKVAIKTLKpgTMMPEAFLQEAQIMKK--LRHDKLVPLYA-----VVSEEPIYIVTEFMSKG 352
Cdd:cd14220   2 QIGKGRYGEVWMGKWRGE-KVAVKVFF--TTEEASWFRETEIYQTvlMRHENILGFIAadikgTGSWTQLYLITDYHENG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIERMNY--------IHRDLRAANILVGENLICKIADFGLARLIE---- 420
Cdd:cd14220  79 SLYDFLK---CTTLDTRALLKLAYSAACGLCHLHTEIYgtqgkpaiAHRDLKSKNILIKKNGTCCIADLGLAVKFNsdtn 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 --DNEYTARQGAKfpiKWTAPEA------ALYGRFTIKSDVWSFGILQTEL----VTKG-----RVPYPGMVNREvlEQV 483
Cdd:cd14220 156 evDVPLNTRVGTK---RYMAPEVldeslnKNHFQAYIMADIYSFGLIIWEMarrcVTGGiveeyQLPYYDMVPSD--PSY 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  484 ERGYRMPCPQG-------------CPESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd14220 231 EDMREVVCVKRlrptvsnrwnsdeCLRAVLKLMSECWAHNPASRLTALRIKKTL 284
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
277-474 3.41e-19

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 88.74  E-value: 3.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGT-TKVAIKtlkpgtMMPEAF---------LQEAQIMKKLRHDKLVPLYAVV------SEE 340
Cdd:cd07834   4 LLKPIGSGAYGVVCSAYDKRTgRKVAIK------KISNVFddlidakriLREIKILRHLKHENIIGLLDILrppspeEFN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMskgslldflkEGD-GKYLKLPQ-LVD-----MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADF 413
Cdd:cd07834  78 DVYIVTELM----------ETDlHKVIKSPQpLTDdhiqyFLYQILRGLKYLHSAGVIHRDLKPSNILVNSNCDLKICDF 147
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  414 GLARLIEDN-------EYTARQgakfpikW-TAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPGM 474
Cdd:cd07834 148 GLARGVDPDedkgfltEYVVTR-------WyRAPELLLsSKKYTKAIDIWSVGCIFAELLT-RKPLFPGR 209
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
280-524 3.64e-19

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 87.77  E-value: 3.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTM---MPEAFLQEAQIMKKLR-HDKLVPLYAVVSE-EPIYIVTEFMSkGS 353
Cdd:cd07832   7 RIGEGAHGIVFKAKDRETGEtVALKKVALRKLeggIPNQALREIKALQACQgHPYVVKLRDVFPHgTGFVLVFEYML-SS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI---EDNEYTARQGA 430
Cdd:cd07832  86 LSEVLRDEE-RPLTEAQVKRYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGLARLFseeDPRLYSHQVAT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFpikWTAPEaALYG--RFTIKSDVWSFGILQTELVTKgrVP-YPGMVNREVLEQVERGYRMPCPQGCPE--SLHELMNL 505
Cdd:cd07832 165 RW---YRAPE-LLYGsrKYDEGVDLWAVGCIFAELLNG--SPlFPGENDIEQLAIVLRTLGTPNEKTWPEltSLPDYNKI 238
                       250       260
                ....*....|....*....|....*....
gi 6678617  506 CWKKD---------PDERP-TFEYIQSFL 524
Cdd:cd07832 239 TFPESkgirleeifPDCSPeAIDLLKGLL 267
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
281-520 3.97e-19

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 87.11  E-value: 3.97e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-NGTTKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP--IYIVTEFMSKGSL 354
Cdd:cd08223   8 IGKGSYGEVWLVRHkRDRKQYVIKKLnlkNASKRERKAAEQEAKLLSKLKHPNIVSYKESFEGEDgfLYIVMGFCEGGDL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPI 434
Cdd:cd08223  88 YTRLKEQKGVLLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARVLESSSDMATTLIGTPY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 kWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLeQVERGYRMPCPQGCPESLHELMNLCWKKDPDER 514
Cdd:cd08223 168 -YMSPELFSNKPYNHKSDVWALGCCVYEMATLKHAFNAKDMNSLVY-KILEGKLPPMPKQYSPELGELIKAMLHQDPEKR 245

                ....*.
gi 6678617  515 PTFEYI 520
Cdd:cd08223 246 PSVKRI 251
PK_GC-C cd14044
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain ...
317-529 4.44e-19

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-C binds and is activated by the intestinal hormones, guanylin (GN) and uroguanylin (UGN), which are secreted after salty meals to inhibit sodium absorption and induce the secretion of chloride, bicarbonate, and water. GN and UGN are also present in the kidney, where they induce increased salt and water secretion. This prevents the development of hypernatremia and hypervolemia after ingestion of high amounts of salt. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-C subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270946 [Multi-domain]  Cd Length: 271  Bit Score: 87.25  E-value: 4.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHD--KLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEG----DGKYLKLPQLVDMAAQIADGMAYIERMN 389
Cdd:cd14044  50 QKIELNKLLQIDyyNLTKFYGTVKlDTMIFGVIEYCERGSLRDVLNDKisypDGTFMDWEFKISVMYDIAKGMSYLHSSK 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  390 Y-IHRDLRAANILVGENLICKIADFGLARLIEdneytarqgakfPIK--WTAPEAALYGRFTIKSDVWSFGILQTELVTK 466
Cdd:cd14044 130 TeVHGRLKSTNCVVDSRMVVKITDFGCNSILP------------PSKdlWTAPEHLRQAGTSQKGDVYSYGIIAQEIILR 197
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  467 GRVPYpgmvNREVLEQVERGYRMPCPQGCP--------ESLHE-------LMNLCWKKDPDERPTFEYIQSFLEDYFT 529
Cdd:cd14044 198 KETFY----TAACSDRKEKIYRVQNPKGMKpfrpdlnlESAGErerevygLVKNCWEEDPEKRPDFKKIENTLAKIFS 271
SH2_N-SH2_PLC_gamma_like cd10341
N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma; Phospholipase C gamma is a ...
152-241 5.11e-19

N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma; Phospholipase C gamma is a signaling molecule that is recruited to the C-terminal tail of the receptor upon autophosphorylation of a highly conserved tyrosine. PLCgamma is composed of a Pleckstrin homology (PH) domain followed by an elongation factor (EF) domain, 2 catalytic regions of PLC domains that flank 2 tandem SH2 domains (N-SH2, C-SH2), and ending with a SH3 domain and C2 domain. N-SH2 SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. Both N-SH2 and C-SH2 have a very similar binding affinity to pY. But in growth factor stimulated cells these domains bind to different target proteins. N-SH2 binds to pY containing sites in the C-terminal tails of tyrosine kinases and other receptors. Recently it has been shown that this interaction is mediated by phosphorylation-independent interactions between a secondary binding site found exclusively on the N-SH2 domain and a region of the FGFR1 tyrosine kinase domain. This secondary site on the SH2 cooperates with the canonical pY site to regulate selectivity in mediating a specific cellular process. C-SH2 binds to an intramolecular site on PLCgamma itself which allows it to hydrolyze phosphatidylinositol-4,5-bisphosphate into diacylglycerol and inositol triphosphate. These then activate protein kinase C and release calcium. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 199829  Cd Length: 99  Bit Score: 82.01  E-value: 5.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  152 QAEEWYFGKM--GRKDAERLLL--NPGNQrGIFLVRESETTKGAYSLSIrdWdevRGDNVKHYKIRKLDNGG---YYITT 224
Cdd:cd10341   2 FTEPWFHGKLgdGRDEAEKLLLeyCEGGD-GTFLVRESETFVGDYTLSF--W---RNGKVQHCRIRSRQENGekkYYLTD 75
                        90
                ....*....|....*..
gi 6678617  225 RAQFDTLQKLVKHYTEH 241
Cdd:cd10341  76 NLVFDSLYELIDYYRQN 92
SH3_Blk cd12009
Src homology 3 domain of Blk Protein Tyrosine Kinase; Blk is a member of the Src subfamily of ...
95-147 5.38e-19

Src homology 3 domain of Blk Protein Tyrosine Kinase; Blk is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. It is expressed specifically in B-cells and is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212942 [Multi-domain]  Cd Length: 54  Bit Score: 80.63  E-value: 5.38e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNTeGDWWEARSIATGKSGYIPSNYVVP 147
Cdd:cd12009   3 IAQYDFVPSNERDLQLKKGEKLQVLKSD-GEWWLAKSLTTGKEGYIPSNYVAR 54
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
266-518 6.14e-19

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 86.97  E-value: 6.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIpreslrLEVkLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKL-RHDKLVPLYAV------- 336
Cdd:cd06608   6 GIFEL------VEV-IGEGTYGKVYKARHKKTGQlAAIKIMDIIEDEEEEIKLEINILRKFsNHPNIATFYGAfikkdpp 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEEPIYIVTEFMSKGSLLDFLKE--GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG 414
Cdd:cd06608  79 GGDDQLWLVMEYCGGGSVTDLVKGlrKKGKRLKEEWIAYILRETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  415 LARLIeDNEYTARQ---GAKFpikWTAPE--------AALYgrfTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQV 483
Cdd:cd06608 159 VSAQL-DSTLGRRNtfiGTPY---WMAPEviacdqqpDASY---DARCDVWSLGITAIEL-ADGKPPLCDMHPMRALFKI 230
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6678617  484 ERGY--RMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd06608 231 PRNPppTLKSPEKWSKEFNDFISECLIKNYEQRPFTE 267
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
281-520 6.99e-19

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 86.30  E-value: 6.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMG--TWNGTtKVAIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd14663   8 LGEGTFAKVKFArnTKTGE-SVAIKIIDKEQVaregMVEQIKREIAIMKLLRHPNIVELHEVMaTKTKIFFVMELVTGGE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LldFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNE-----YTaRQ 428
Cdd:cd14663  87 L--FSKIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLSALSEQFRqdgllHT-TC 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKfpiKWTAPEA-ALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGyRMPCPQGCPESLHELMNLCW 507
Cdd:cd14663 164 GTP---NYVAPEVlARRGYDGAKADIWSCGVILFVLLA-GYLPFDDENLMALYRKIMKG-EFEYPRWFSPGAKSLIKRIL 238
                       250
                ....*....|...
gi 6678617  508 KKDPDERPTFEYI 520
Cdd:cd14663 239 DPNPSTRITVEQI 251
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
261-485 8.55e-19

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 87.80  E-value: 8.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  261 QGLAKDAWEIPRESLRLeVKLGQGCFGEVwMGTWNGTT--KVAIKTL-KPGTMMPEA--FLQEAQIMKKLRHDKLVPLYA 335
Cdd:cd07878   4 QELNKTVWEVPERYQNL-TPVGSGAYGSV-CSAYDTRLrqKVAVKKLsRPFQSLIHArrTYRELRLLKHMKHENVIGLLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  336 VVSE-------EPIYIVTEFMskGSLLDFLkegdgkyLKLPQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVG 403
Cdd:cd07878  82 VFTPatsienfNEVYLVTNLM--GADLNNI-------VKCQKLSDehvqfLIYQLLRGLKYIHSAGIIHRDLKPSNVAVN 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  404 ENLICKIADFGLARLiEDNEYTARQGAKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVtKGRVPYPGmvnREVLEQ 482
Cdd:cd07878 153 EDCELRILDFGLARQ-ADDEMTGYVATRW---YRAPEIMLnWMHYNQTVDIWSVGCIMAELL-KGKALFPG---NDYIDQ 224

                ...
gi 6678617  483 VER 485
Cdd:cd07878 225 LKR 227
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
280-489 9.10e-19

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 86.79  E-value: 9.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMM---PEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKgSL 354
Cdd:cd07860   7 KIGEGTYGVVYKARNKLTGEvVALKKIRLDTETegvPSTAIREISLLKELNHPNIVKLLDVIhTENKLYLVFEFLHQ-DL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTARQgakF 432
Cdd:cd07860  86 KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAfgVPVRTYTHEV---V 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  433 PIKWTAPEAALYGRF-TIKSDVWSFGILQTELVTKgRVPYPGmvNREVlEQVERGYRM 489
Cdd:cd07860 163 TLWYRAPEILLGCKYySTAVDIWSLGCIFAEMVTR-RALFPG--DSEI-DQLFRIFRT 216
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
276-522 9.74e-19

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 85.85  E-value: 9.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGTT-KVAIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd14075   5 RIRGELGSGNFSQVKLGIHQLTKeKVAIKILDKTKLdqkTQRLLSREISSMEKLHHPNIIRLYEVVeTLSKLHLVMEYAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDF------LKEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDNEY 424
Cdd:cd14075  85 GGELYTKistegkLSESEAKPL--------FAQIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHA-KRGE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPiKWTAPE----AALYGRFTiksDVWSFGILQTELVTkGRVPY-----PGMvNREVLEQvergyRMPCPQGC 495
Cdd:cd14075 156 TLNTFCGSP-PYAAPElfkdEHYIGIYV---DIWALGVLLYFMVT-GVMPFraetvAKL-KKCILEG-----TYTIPSYV 224
                       250       260
                ....*....|....*....|....*..
gi 6678617  496 PESLHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14075 225 SEPCQELIRGILQPVPSDRYSIDEIKN 251
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
281-528 1.51e-18

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 85.45  E-value: 1.51e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMP-----EAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSL 354
Cdd:cd14188   9 LGKGGFAKCYEMTDLTTNKVYAAKIIPHSRVSkphqrEKIDKEIELHRILHHKHVVQFYHYFEDkENIYILLEYCSRRSM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPi 434
Cdd:cd14188  89 AHILKAR--KVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAARLEPLEHRRRTICGTP- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWTAPEAALYGRFTIKSDVWSFG-ILQTELVtkGRVPYPGMVNREVLEQVeRGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd14188 166 NYLSPEVLNKQGHGCESDIWALGcVMYTMLL--GRPPFETTNLKETYRCI-REARYSLPSSLLAPAKHLIASMLSKNPED 242
                       250
                ....*....|....*
gi 6678617  514 RPTFEYIqsFLEDYF 528
Cdd:cd14188 243 RPSLDEI--IRHDFF 255
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
260-473 1.64e-18

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 86.93  E-value: 1.64e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  260 TQGLAKDAWEIPrESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTL-KP--GTMMPEAFLQEAQIMKKLRHDKLVPLYA 335
Cdd:cd07880   3 RQEVNKTIWEVP-DRYRDLKQVGSGAYGTVCSALDRRTgAKVAIKKLyRPfqSELFAKRAYRELRLLKHMKHENVIGLLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  336 VVSEE-------PIYIVTEFMskGSLLdflkegdGKYLKLPQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVG 403
Cdd:cd07880  82 VFTPDlsldrfhDFYLVMPFM--GTDL-------GKLMKHEKLSEdriqfLVYQMLKGLKYIHAAGIIHRDLKPGNLAVN 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678617  404 ENLICKIADFGLARLiEDNEYTARQGAKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd07880 153 EDCELKILDFGLARQ-TDSEMTGYVVTRW---YRAPEVILnWMHYTQTVDIWSVGCIMAEMLT-GKPLFKG 218
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
280-459 1.83e-18

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 85.52  E-value: 1.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMM---------PEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEF 348
Cdd:cd14084  13 TLGSGACGEVKLAYDKSTcKKVAIKIINKRKFTigsrreinkPRNIETEIEILKKLSHPCIIKIEDFFdAEDDYYIVLEL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLD------FLKEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVG---ENLICKIADFGLAR-L 418
Cdd:cd14084  93 MEGGELFDrvvsnkRLKEAICKLY--------FYQMLLAVKYLHSNGIIHRDLKPENVLLSsqeEECLIKITDFGLSKiL 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6678617  419 IEDNEYTARQGAkfpIKWTAPEA-ALYGR--FTIKSDVWSFGIL 459
Cdd:cd14084 165 GETSLMKTLCGT---PTYLAPEVlRSFGTegYTRAVDCWSLGVI 205
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
338-532 1.88e-18

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 88.15  E-value: 1.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   338 SEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVD--MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGL 415
Cdd:PTZ00267 136 SDDKLLLIMEYGSGGDLNKQIKQRLKEHLPFQEYEVglLFYQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGF 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   416 ARLIEDNeYTARQGAKF---PIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRvPYPGMVNREVLEQVERGYRMPCP 492
Cdd:PTZ00267 216 SKQYSDS-VSLDVASSFcgtPY-YLAPELWERKRYSKKADMWSLGVILYELLTLHR-PFKGPSQREIMQQVLYGKYDPFP 292
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 6678617   493 QGCPESLHELMNLCWKKDPDERPT---------FEYIQSFLEDYFTATE 532
Cdd:PTZ00267 293 CPVSSGMKALLDPLLSKNPALRPTtqqllhtefLKYVANLFQDIVRHSE 341
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
281-522 2.12e-18

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 85.03  E-value: 2.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTW-NGTTKVAIKTLKpgtmMPEAF------LQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKG 352
Cdd:cd08219   8 VGEGSFGRALLVQHvNSDQKYAMKEIR----LPKSSsavedsRKEAVLLAKMKHPNIVAFKeSFEADGHLYIVMEYCDGG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF 432
Cdd:cd08219  84 DLMQKIKLQRGKLFPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLTSPGAYACTYVGT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 512
Cdd:cd08219 164 PY-YVPPEIWENMPYNNKSDIWSLGCILYELCTL-KHPFQANSWKNLILKVCQGSYKPLPSHYSYELRSLIKQMFKRNPR 241
                       250
                ....*....|
gi 6678617  513 ERPTFEYIQS 522
Cdd:cd08219 242 SRPSATTILS 251
PTK_Jak1_rpt1 cd05077
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely ...
299-520 2.18e-18

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits, common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270662 [Multi-domain]  Cd Length: 266  Bit Score: 84.99  E-value: 2.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  299 KVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLlDFLKEGDGKYLKLPQLVDMAA 376
Cdd:cd05077  38 KVILKVLDPSHRdISLAFFETASMMRQVSHKHIVLLYGVcVRDVENIMVEEFVEFGPL-DLFMHRKSDVLTTPWKFKVAK 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  377 QIADGMAYIERMNYIHRDLRAANILVGENLI-------CKIADFGLARLIedneyTARQGAKFPIKWTAPEAALYGR-FT 448
Cdd:cd05077 117 QLASALSYLEDKDLVHGNVCTKNILLAREGIdgecgpfIKLSDPGIPITV-----LSRQECVERIPWIAPECVEDSKnLS 191
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  449 IKSDVWSFGILQTELVTKGRVPypgmVNREVLEQVERGYR---MPCPQGCPEsLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd05077 192 IAADKWSFGTTLWEICYNGEIP----LKDKTLAEKERFYEgqcMLVTPSCKE-LADLMTHCMNYDPNQRPFFRAI 261
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
280-528 2.49e-18

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 84.86  E-value: 2.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGE-VWMGTWNGTTKVAIKTLKPGTMMP---EAFLQEAQIMKKLRHDKLVPlYAVVSEE--PIYIVTEFMSKGS 353
Cdd:cd08218   7 KIGEGSFGKaLLVKSKEDGKQYVIKEINISKMSPkerEESRKEVAVLSKMKHPNIVQ-YQESFEEngNLYIVMDYCDGGD 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFP 433
Cdd:cd08218  86 LYKRINAQRGVLFPEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVLNSTVELARTCIGTP 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 IkWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLeQVERGYRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd08218 166 Y-YLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVL-KIIRGSYPPVPSRYSYDLRSLVSQLFKRNPRD 243
                       250
                ....*....|....*
gi 6678617  514 RPTfeyIQSFLEDYF 528
Cdd:cd08218 244 RPS---INSILEKPF 255
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
281-516 2.79e-18

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 84.63  E-value: 2.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPgtmMPEAFLQ---EAQIMKKLR------HDKLVPLY-AVVSEEPIYIVTEFM 349
Cdd:cd14133   7 LGKGTFGQVVKCYDLLTGEeVALKIIKN---NKDYLDQsldEIRLLELLNkkdkadKYHIVRLKdVFYFKNHLCIVFELL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLIC--KIADFGLARLIEDNEYTAR 427
Cdd:cd14133  84 SQ-NLYEFLKQNKFQYLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLASYSRCqiKIIDFGSSCFLTQRLYSYI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QgAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYP---------------GMVNREVLEQveRGYRMPCp 492
Cdd:cd14133 163 Q-SRY---YRAPEVILGLPYDEKIDMWSLGCILAELYT-GEPLFPgasevdqlariigtiGIPPAHMLDQ--GKADDEL- 234
                       250       260
                ....*....|....*....|....
gi 6678617  493 qgcpesLHELMNLCWKKDPDERPT 516
Cdd:cd14133 235 ------FVDFLKKLLEIDPKERPT 252
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
281-470 3.07e-18

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 85.26  E-value: 3.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNgTTKVAIKTLKPG-----TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSL 354
Cdd:cd14159   1 IGEGGFGCVYQAVMR-NTEYAVKRLKEDseldwSVVKNSFLTEVEKLSRFRHPNIVDLAGYSAQQGNYcLIYVYLPNGSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLK-EGDGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLARLIE------DNEYT 425
Cdd:cd14159  80 EDRLHcQVSCPCLSWSQRLHVLLGTARAIQYLHSDSpsLIHGDVKSSNILLDAALNPKLGDFGLARFSRrpkqpgMSSTL 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  426 AR-QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVP 470
Cdd:cd14159 160 ARtQTVRGTLAYLPEEYVKTGTLSVEIDVYSFGVVLLELLT-GRRA 204
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
281-526 3.09e-18

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 85.54  E-value: 3.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVA-IKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY--AVVSEEP------IYIVTEFMSK 351
Cdd:cd06637  14 VGNGTYGQVYKGRHVKTGQLAaIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYygAFIKKNPpgmddqLWLVMEFCGA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDNEYTARQGAK 431
Cdd:cd06637  94 GSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGRRNTFI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIKWTAPEAALY-----GRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGyrmPCP----QGCPESLHEL 502
Cdd:cd06637 173 GTPYWMAPEVIACdenpdATYDFKSDLWSLGITAIEM-AEGAPPLCDMHPMRALFLIPRN---PAPrlksKKWSKKFQSF 248
                       250       260
                ....*....|....*....|....*.
gi 6678617  503 MNLCWKKDPDERPTFEYI--QSFLED 526
Cdd:cd06637 249 IESCLVKNHSQRPSTEQLmkHPFIRD 274
PTK_Jak2_rpt1 cd05078
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely ...
275-520 3.40e-18

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Despite this, the presumed pseudokinase (repeat 1) domain of Jak2 exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Inactivation of the repeat 1 domain increased Jak2 basal activity, suggesting that it modulates the kinase activity of the C-terminal catalytic (repeat 2) domain. The Jak2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270663 [Multi-domain]  Cd Length: 262  Bit Score: 84.61  E-value: 3.40e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVW------MGTWNG--TTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV--SEEPIy 343
Cdd:cd05078   1 LIFNESLGQGTFTKIFkgirreVGDYGQlhETEVLLKVLdKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCvcGDENI- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMSKGSLLDFLKEgDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV--------GENLICKIADFGL 415
Cdd:cd05078  80 LVQEYVKFGSLDTYLKK-NKNCINILWKLEVAKQLAWAMHFLEEKTLVHGNVCAKNILLireedrktGNPPFIKLSDPGI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  416 ARLIEDNEYTARQgakfpIKWTAPEAALYGR-FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG 494
Cdd:cd05078 159 SITVLPKDILLER-----IPWVPPECIENPKnLSLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKW 233
                       250       260
                ....*....|....*....|....*.
gi 6678617  495 CpeSLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd05078 234 T--ELANLINNCMDYEPDHRPSFRAI 257
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
280-473 3.83e-18

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 85.82  E-value: 3.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKP--GTMMPEAFLQEAQIMKKLRHDKLVPLYAVV------SEEPIYIVTEFMs 350
Cdd:cd07849  12 YIGEGAYGMVCSAVHKPTgQKVAIKKISPfeHQTYCLRTLREIKILLRFKHENIIGILDIQrpptfeSFKDVYIVQELM- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 kgslldflkEGD-GKYLKLPQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI---ED 421
Cdd:cd07849  91 ---------ETDlYKLIKTQHLSNdhiqyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARIAdpeHD 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  422 N-----EYTArqgakfpIKW-TAPEAALYGRFTIKS-DVWSFGILQTELVTkGRVPYPG 473
Cdd:cd07849 162 HtgfltEYVA-------TRWyRAPEIMLNSKGYTKAiDIWSVGCILAEMLS-NRPLFPG 212
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
273-520 4.41e-18

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 84.14  E-value: 4.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMG-TWNGTTKVAIKTLKPGTM----MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVT 346
Cdd:cd14186   1 EDFKVLNLLGKGSFACVYRArSLHTGLEVAIKMIDKKAMqkagMVQRVRNEVEIHCQLKHPSILELYNYFEDSNyVYLVL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEgdgkyLKLPQLVDMAA----QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA---RLI 419
Cdd:cd14186  81 EMCHNGEMSRYLKN-----RKKPFTEDEARhfmhQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAtqlKMP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EDNEYTArqgAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMpcPQGCPES 498
Cdd:cd14186 156 HEKHFTM---CGTP-NYISPEIATRSAHGLESDVWSLGCMFYTLLV-GRPPFDTDTVKNTLNKVVLAdYEM--PAFLSRE 228
                       250       260
                ....*....|....*....|..
gi 6678617  499 LHELMNLCWKKDPDERPTFEYI 520
Cdd:cd14186 229 AQDLIHQLLRKNPADRLSLSSV 250
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
276-485 4.41e-18

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 84.45  E-value: 4.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEvKLGQGCFGEVWMGTwNGTTK--VAIKTLK----PGTmmPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEF 348
Cdd:cd07836   4 QLE-KLGEGTYATVYKGR-NRTTGeiVALKEIHldaeEGT--PSTAIREISLMKELKHENIVRLHDVIhTENKLMLVFEY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKgsllDFLK----EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDN 422
Cdd:cd07836  80 MDK----DLKKymdtHGVRGALDPNTVKSFTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAfgIPVN 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678617  423 EYTARQgakFPIKWTAPEAALYGR-FTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER 485
Cdd:cd07836 156 TFSNEV---VTLWYRAPDVLLGSRtYSTSIDIWSVGCIMAEMIT-GRPLFPGTNNEDQLLKIFR 215
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
254-522 4.45e-18

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 84.70  E-value: 4.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  254 PTVKPQtQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTKVAIKTLKPGTMMP----EAFLQEAQIMKKLRHD 328
Cdd:cd08229   6 PQFQPQ-KALRPDMGYNTLANFRIEKKIGRGQFSEVYRATCLlDGVPVALKKVQIFDLMDakarADCIKEIDLLKQLNHP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  329 KLVPLYA-VVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQ--LVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN 405
Cdd:cd08229  85 NVIKYYAsFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPEktVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITAT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  406 LICKIADFGLARLIEDNEYTARQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVL-EQVE 484
Cdd:cd08229 165 GVVKLGDLGLGRFFSSKTTAAHSLVGTPY-YMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLcKKIE 243
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6678617  485 RGYRMPCPQG-CPESLHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd08229 244 QCDYPPLPSDhYSEELRQLVNMCINPDPEKRPDITYVYD 282
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
280-516 4.67e-18

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 85.09  E-value: 4.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTwNGTTK--VAIKTLK-PGTMMPEAF---LQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFmSKG 352
Cdd:cd06633  28 EIGHGSFGAVYFAT-NSHTNevVAIKKMSySGKQTNEKWqdiIKEVKFLQQLKHPNTIEYKGCyLKDHTAWLVMEY-CLG 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED-NEYTarqGAK 431
Cdd:cd06633 106 SASDLL-EVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPaNSFV---GTP 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FpikWTAPEAALY---GRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGyRMPCPQG--CPESLHELMNLC 506
Cdd:cd06633 182 Y---WMAPEVILAmdeGQYDGKVDIWSLGITCIELAER-KPPLFNMNAMSALYHIAQN-DSPTLQSneWTDSFRGFVDYC 256
                       250
                ....*....|
gi 6678617  507 WKKDPDERPT 516
Cdd:cd06633 257 LQKIPQERPS 266
SH3 smart00326
Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences ...
90-145 6.69e-18

Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.


Pssm-ID: 214620 [Multi-domain]  Cd Length: 56  Bit Score: 77.58  E-value: 6.69e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617      90 GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIaTGKSGYIPSNYV 145
Cdd:smart00326   1 EGPQVRALYDYTAQDPDELSFKKGDIITVLEKSDDGWWKGRLG-RGKEGLFPSNYV 55
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
281-516 8.00e-18

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 83.57  E-value: 8.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVwmgtwngtTKV---------AIK--TLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEF 348
Cdd:cd14046  14 LGKGAFGQV--------VKVrnkldgryyAIKkiKLRSESKNNSRILREVMLLSRLNHQHVVRYYqAWIERANLYIQMEY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKegDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA------------ 416
Cdd:cd14046  86 CEKSTLRDLID--SGLFQDTDRLWRLFRQILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGLAtsnklnvelatq 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 --------RLIEDNEYTARQGAKFpikWTAPE--AALYGRFTIKSDVWSFGILQTELVtkgrvpYP---GMVNREVLEQV 483
Cdd:cd14046 164 dinkstsaALGSSGDLTGNVGTAL---YVAPEvqSGTKSTYNEKVDMYSLGIIFFEMC------YPfstGMERVQILTAL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6678617  484 eRGYRMPCPQGCPESLHE--------LMNlcwkKDPDERPT 516
Cdd:cd14046 235 -RSVSIEFPPDFDDNKHSkqaklirwLLN----HDPAKRPS 270
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
280-516 8.73e-18

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 83.63  E-value: 8.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVwMGTWNGTTK--VAIKTLKPG---TMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGS 353
Cdd:cd07846   8 LVGEGSYGMV-MKCRHKETGqiVAIKKFLESeddKMVKKIAMREIKMLKQLRHENLVNLIEVFRRKKrWYLVFEFVDHTV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNE-YTARQGAK 431
Cdd:cd07846  87 LDDLEKYPNG--LDESRVRKYLFQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARtLAAPGEvYTDYVATR 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FpikWTAPEAAL----YGRftiKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER--------------------GY 487
Cdd:cd07846 165 W---YRAPELLVgdtkYGK---AVDVWAVGCLVTEMLT-GEPLFPGDSDIDQLYHIIKclgnliprhqelfqknplfaGV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6678617  488 RMP-----------CPQGCPESLhELMNLCWKKDPDERPT 516
Cdd:cd07846 238 RLPevkeveplerrYPKLSGVVI-DLAKKCLHIDPDKRPS 276
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
281-522 8.89e-18

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 82.99  E-value: 8.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEaFLQ-----EAQIMKKLRHDKLVPLYAV--VSEEPIYIVTEFMSKg 352
Cdd:cd14164   8 IGEGSFSKVKLATSQKyCCKVAIKIVDRRRASPD-FVQkflprELSILRRVNHPNIVQMFECieVANGRLYIVMEAAAT- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-GENLICKIADFGLARLIED--NEYTARQG 429
Cdd:cd14164  86 DLLQKIQEV--HHIPKDLARDMFAQMVGAVNYLHDMNIVHRDLKCENILLsADDRKIKIADFGFARFVEDypELSTTFCG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AKfpiKWTAPEAALYGRFTIKS-DVWSFGILQTELVTkGRVPYPGMVNREVLEQvERGYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd14164 164 SR---AYTPPEVILGTPYDPKKyDVWSLGVVLYVMVT-GTMPFDETNVRRLRLQ-QRGVLYPSGVALEEPCRALIRTLLQ 238
                       250
                ....*....|....
gi 6678617  509 KDPDERPTFEYIQS 522
Cdd:cd14164 239 FNPSTRPSIQQVAG 252
SH2_Grb2_like cd09941
Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar ...
156-241 9.28e-18

Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins; The adaptor proteins here include homologs Grb2 in humans, Sex muscle abnormal protein 5 (Sem-5) in Caenorhabditis elegans, and Downstream of receptor kinase (drk) in Drosophila melanogaster. They are composed of one SH2 and two SH3 domains. Grb2/Sem-5/drk regulates the Ras pathway by linking the tyrosine kinases to the Ras guanine nucleotide releasing protein Sos, which converts Ras to the active GTP-bound state. The SH2 domain of Grb2/Sem-5/drk binds class II phosphotyrosyl peptides while its SH3 domain binds to Sos and Sos-derived, proline-rich peptides. Besides it function in Ras signaling, Grb2 is also thought to play a role in apoptosis. Unlike most SH2 structures in which the peptide binds in an extended conformation (such that the +3 peptide residue occupies a hydrophobic pocket in the protein, conferring a modest degree of selectivity), Grb2 forms several hydrogen bonds via main chain atoms with the side chain of +2 Asn. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 199828  Cd Length: 95  Bit Score: 78.47  E-value: 9.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNqRGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGYYITTrAQFDTLQKLV 235
Cdd:cd09941   5 WFHGKISRAEAEEILMNQRP-DGAFLIRESESSPGDFSLSVKF-----GNDVQHFKVLRDGAGKYFLWV-VKFNSLNELV 77

                ....*.
gi 6678617  236 KHYTEH 241
Cdd:cd09941  78 DYHRTT 83
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
280-466 1.01e-17

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 83.62  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSkgsl 354
Cdd:cd07861   7 KIGEGTYGVVYKGRNKKTGQiVAMKKIRLESEeegVPSTAIREISLLKELQHPNIVCLEDVLMQENrLYLVFEFLS---- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGD----GKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTARQ 428
Cdd:cd07861  83 MDLKKYLDslpkGKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARAfgIPVRVYTHEV 162
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6678617  429 gakFPIKWTAPEAALYG-RFTIKSDVWSFGILQTELVTK 466
Cdd:cd07861 163 ---VTLWYRAPEVLLGSpRYSTPVDIWSIGTIFAEMATK 198
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
280-517 1.10e-17

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 83.36  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTLKpgTMMPEA----FLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGS 353
Cdd:cd06622   8 ELGKGNYGSVYKVLHRPTGVTmAMKEIR--LELDESkfnqIIMELDILHKAVSPYIVDFYgAFFIEGAVYMCMEYMDAGS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LlDFLKEGDGKYLKLP--QLVDMAAQIADGMAYI-ERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGA 430
Cdd:cd06622  86 L-DKLYAGGVATEGIPedVLRRITYAVVKGLKFLkEEHNIIHRDVKPTNVLVNGNGQVKLCDFGVSGNLVASLAKTNIGC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KfpiKWTAPE------AALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVE---RGYRMPCPQGCPESLHE 501
Cdd:cd06622 165 Q---SYMAPEriksggPNQNPTYTVQSDVWSLGLSILEM-ALGRYPYPPETYANIFAQLSaivDGDPPTLPSGYSDDAQD 240
                       250
                ....*....|....*.
gi 6678617  502 LMNLCWKKDPDERPTF 517
Cdd:cd06622 241 FVAKCLNKIPNRRPTY 256
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
281-473 1.19e-17

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 84.16  E-value: 1.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTL-KPGT--MMPEAFLQEAQIMKKLRHDKLVPLYAVVSE--EPIYIVTEFMskGSL 354
Cdd:cd07856  18 VGMGAFGLVCSARDQLTgQNVAVKKImKPFStpVLAKRTYRELKLLKHLRHENIISLSDIFISplEDIYFVTELL--GTD 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLkegdgkyLKLPQLVDMAAQ-----IADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARlIEDNEYTARQG 429
Cdd:cd07856  96 LHRL-------LTSRPLEKQFIQyflyqILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLAR-IQDPQMTGYVS 167
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6678617  430 AKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVtKGRVPYPG 473
Cdd:cd07856 168 TRY---YRAPEIMLtWQKYDVEVDIWSAGCIFAEML-EGKPLFPG 208
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
271-516 1.21e-17

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 82.88  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKtlkpgtMMP-------EAFLQEAQIMKKLRHDKLVPLYA--VVSEE 340
Cdd:cd06648   5 PRSDLDNFVKIGEGSTGIVCIATDKSTgRQVAVK------KMDlrkqqrrELLFNEVVIMRDYQHPNIVEMYSsyLVGDE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 pIYIVTEFMSKGSLLDFLKEGDgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE 420
Cdd:cd06648  79 -LWVVMEFLEGGALTDIVTHTR---MNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGFCAQVS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 DNEYTARQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmVNREVLEQVERGYRMPCP------QG 494
Cdd:cd06648 155 KEVPRRKSLVGTPY-WMAPEVISRLPYGTEVDIWSLGIMVIEMV-DGEPPY---FNEPPLQAMKRIRDNEPPklknlhKV 229
                       250       260
                ....*....|....*....|..
gi 6678617  495 CPEsLHELMNLCWKKDPDERPT 516
Cdd:cd06648 230 SPR-LRSFLDRMLVRDPAQRAT 250
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
266-516 1.44e-17

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 83.16  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPREslrlevkLGQGCFGEVWMGTWNGTTKVA----IKTLKPGTMmpEAFLQEAQIMKKLRHDKLVPLY-AVVSEE 340
Cdd:cd06644  12 EVWEIIGE-------LGDGAFGKVYKAKNKETGALAaakvIETKSEEEL--EDYMVEIEILATCNHPYIVKLLgAFYWDG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKGSLLDFLKEGDgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLArliE 420
Cdd:cd06644  83 KLWIMIEFCPGGAVDAIMLELD-RGLTEPQIQVICRQMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVS---A 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 DNEYTARQGAKF---PIkWTAPEAALY-----GRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGY--RMP 490
Cdd:cd06644 159 KNVKTLQRRDSFigtPY-WMAPEVVMCetmkdTPYDYKADIWSLGITLIEM-AQIEPPHHELNPMRVLLKIAKSEppTLS 236
                       250       260
                ....*....|....*....|....*.
gi 6678617  491 CPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd06644 237 QPSKWSMEFRDFLKTALDKHPETRPS 262
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
281-486 1.48e-17

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 82.66  E-value: 1.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVsEEP--IYIVTEFMSKGSLLD 356
Cdd:cd14190  12 LGGGKFGKVHTCTEKRTgLKLAAKVInKQNSKDKEMVLLEIQVMNQLNHRNLIQLYEAI-ETPneIVLFMEYVEGGELFE 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKYLKLPQLVdMAAQIADGMAYIERMNYIHRDLRAANILV--GENLICKIADFGLARliednEYTARQGAKFPI 434
Cdd:cd14190  91 RIVDEDYHLTEVDAMV-FVRQICEGIQFMHQMRVLHLDLKPENILCvnRTGHQVKIIDFGLAR-----RYNPREKLKVNF 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  435 ---KWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYPGMVNREVLEQVERG 486
Cdd:cd14190 165 gtpEFLSPEVVNYDQVSFPTDMWSMGVI-TYMLLSGLSPFLGDDDTETLNNVLMG 218
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
335-521 1.50e-17

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 82.86  E-value: 1.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  335 AVVSEEPIYIVTEFMSKgSLLDFLKEGDGKYLKLPQ--LVDMAAQIADGMAYI-ERMNYIHRDLRAANILVGENLICKIA 411
Cdd:cd06617  68 ALFREGDVWICMEVMDT-SLDKFYKKVYDKGLTIPEdiLGKIAVSIVKALEYLhSKLSVIHRDVKPSNVLINRNGQVKLC 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLA-RLIEDNEYTARQGAKfpiKWTAPE----AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQVER 485
Cdd:cd06617 147 DFGISgYLVDSVAKTIDAGCK---PYMAPErinpELNQKGYDVKSDVWSLGITMIELAT-GRFPYDSWKTPfQQLKQVVE 222
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6678617  486 GyrmPCPQ----GCPESLHELMNLCWKKDPDERPTFEYIQ 521
Cdd:cd06617 223 E---PSPQlpaeKFSPEFQDFVNKCLKKNYKERPNYPELL 259
SH2_Srm cd10360
Src homology 2 (SH2) domain found in Src-related kinase lacking C-terminal regulatory tyrosine ...
156-238 1.65e-17

Src homology 2 (SH2) domain found in Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (srm); Srm is a nonreceptor protein kinase that has two SH2 domains, a SH3 domain, and a kinase domain with a tyrosine residue for autophosphorylation. However it lacks an N-terminal glycine for myristoylation and a C-terminal tyrosine which suppresses kinase activity when phosphorylated. Srm is most similar to members of the Tec family who other members include: Tec, Btk/Emb, and Itk/Tsk/Emt. However Srm differs in its N-terminal unique domain it being much smaller than in the Tec family and is closer to Src. Srm is thought to be a new family of nonreceptor tyrosine kinases that may be redundant in function. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198223  Cd Length: 79  Bit Score: 77.30  E-value: 1.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEvrgdnVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd10360   2 WYFSGISRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHYRICMAPSGSLYLQKGRLFPGLEELL 76

                ...
gi 6678617  236 KHY 238
Cdd:cd10360  77 AYY 79
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
271-471 2.47e-17

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 81.90  E-value: 2.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTL----KPGTmmpEAFLQEAQIMKKLRHDKLVPLYA--VVSEEpIY 343
Cdd:cd06647   5 PKKKYTRFEKIGQGASGTVYTAIDVATgQEVAIKQMnlqqQPKK---ELIINEILVMRENKNPNIVNYLDsyLVGDE-LW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--ED 421
Cdd:cd06647  81 VVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQ 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPY 471
Cdd:cd06647 158 SKRSTMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPY 203
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
268-525 2.64e-17

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 81.98  E-value: 2.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLrlevkLGQGCFGEVWMG--TWNGTTKVAIKTLKPGTMMPEAFL--QEAQIMKKLRHDKLVPLYAVVS-EEPI 342
Cdd:cd14202   2 FEFSRKDL-----IGHGAFAVVFKGrhKEKHDLEVAVKCINKKNLAKSQTLlgKEIKILKELKHENIVALYDFQEiANSV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG---------ENLICKIADF 413
Cdd:cd14202  77 YLVMEYCNGGDLADYLHTM--RTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSysggrksnpNNIRIKIADF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  414 GLARLIEDNEYTARQGAKfPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRM--PC 491
Cdd:cd14202 155 GFARYLQNNMMAATLCGS-PM-YMAPEVIMSQHYDAKADLWSIGTIIYQCLT-GKAPFQASSPQDLRLFYEKNKSLspNI 231
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6678617  492 PQGCPESLHELMNLCWKKDPDERPTFE--YIQSFLE 525
Cdd:cd14202 232 PRETSSHLRQLLLGLLQRNQKDRMDFDefFHHPFLD 267
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
274-474 2.68e-17

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 82.55  E-value: 2.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLkpgtmmpeafLQ-------EAQIMKKLRHDKLVPL-YAVVSEEP--- 341
Cdd:cd14137   5 SYTIEKVIGSGSFGVVYQAKLLETGEvVAIKKV----------LQdkryknrELQIMRRLKHPNIVKLkYFFYSSGEkkd 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 ---IYIVTEFMSKgSLLDFLKegdgKYLKLPQLVDM------AAQIADGMAYIERMNYIHRDLRAANILV-GENLICKIA 411
Cdd:cd14137  75 evyLNLVMEYMPE-TLYRVIR----HYSKNKQTIPIiyvklySYQLFRGLAYLHSLGICHRDIKPQNLLVdPETGVLKLC 149
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  412 DFGLARLIEDNE----------YtaRqgakfpikwtAPEaALYG--RFTIKSDVWSFGILQTELVtKGRVPYPGM 474
Cdd:cd14137 150 DFGSAKRLVPGEpnvsyicsryY--R----------APE-LIFGatDYTTAIDIWSAGCVLAELL-LGQPLFPGE 210
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
316-526 3.31e-17

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 81.96  E-value: 3.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKLRHDKLVPL--YAVVSEEP----IYIVTEFMSKGSLLDFLKEGD--GKYLKLPQLVDMAAQIADGMAYI-- 385
Cdd:cd13986  45 MREIENYRLFNHPNILRLldSQIVKEAGgkkeVYLLLPYYKRGSLQDEIERRLvkGTFFPEDRILHIFLGICRGLKAMhe 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  386 -ERMNYIHRDLRAANILVGENLICKIADFG---LARL-IEDN-EYTARQ---GAKFPIKWTAPEAalygrFTIKS----- 451
Cdd:cd13986 125 pELVPYAHRDIKPGNVLLSEDDEPILMDLGsmnPARIeIEGRrEALALQdwaAEHCTMPYRAPEL-----FDVKShctid 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  452 ---DVWSFG-ILQTELVTKGrvPYpgmvnrEVLEQveRG-----------YRMPCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd13986 200 ektDIWSLGcTLYALMYGES--PF------ERIFQ--KGdslalavlsgnYSFPDNSRYSEELHQLVKSMLVVNPAERPS 269
                       250
                ....*....|
gi 6678617  517 FEYIQSFLED 526
Cdd:cd13986 270 IDDLLSRVHD 279
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
317-486 3.32e-17

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 81.76  E-value: 3.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDL 395
Cdd:cd14105  57 REVSILRQVLHPNIITLHDVFeNKTDVVLILELVAGGELFDFLAEKES--LSEEEATEFLKQILDGVNYLHTKNIAHFDL 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  396 RAANILVGENLI----CKIADFGLARLIED-NEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVP 470
Cdd:cd14105 135 KPENIMLLDKNVpiprIKLIDFGLAHKIEDgNEFKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGVI-TYILLSGASP 210
                       170
                ....*....|....*.
gi 6678617  471 YPGMVNREVLEQVERG 486
Cdd:cd14105 211 FLGDTKQETLANITAV 226
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
273-518 3.59e-17

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 81.85  E-value: 3.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEF 348
Cdd:cd06619   1 QDIQYQEILGHGNGGTVYKAYHLLTRRILAVKVIPLDITVElqkQIMSELEILYKCDSPYIIGFYgAFFVENRISICTEF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLldflkegdGKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06619  81 MDGGSL--------DVYRKIPEHVlgRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYP-------GMVNREVLEQV--ERGYRMPCPQGCPE 497
Cdd:cd06619 153 YVGTN---AYMAPERISGEQYGIHSDVWSLGISFMELAL-GRFPYPqiqknqgSLMPLQLLQCIvdEDPPVLPVGQFSEK 228
                       250       260
                ....*....|....*....|.
gi 6678617  498 SLHeLMNLCWKKDPDERPTFE 518
Cdd:cd06619 229 FVH-FITQCMRKQPKERPAPE 248
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
281-458 3.81e-17

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 81.12  E-value: 3.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVA----IKTLKPGTMmpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd14103   1 LGRGKFGTVYRCVEKATGKELaakfIKCRKAKDR--EDVRNEIEIMNQLRHPRLLQLYdAFETPREMVLVMEYVAGGELF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 D-------FLKEGDG-KYLKlpqlvdmaaQIADGMAYIERMNYIHRDLRAANILV---GENLIcKIADFGLARLIEDNEy 424
Cdd:cd14103  79 ErvvdddfELTERDCiLFMR---------QICEGVQYMHKQGILHLDLKPENILCvsrTGNQI-KIIDFGLARKYDPDK- 147
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6678617  425 tarqgakfPIK-------WTAPEAALYGRFTIKSDVWSFGI 458
Cdd:cd14103 148 --------KLKvlfgtpeFVAPEVVNYEPISYATDMWSVGV 180
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
276-518 5.43e-17

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 81.37  E-value: 5.43e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVkLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEA--FLQEAQIMKKLRHDK---LVPLYAVVSEEP-IYIVTEF 348
Cdd:cd06917   5 RLEL-VGRGSYGAVYRGYHVKTGRvVALKVLNLDTDDDDVsdIQKEVALLSQLKLGQpknIIKYYGSYLKGPsLWIIMDY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEG--DGKYLKLpqlvdMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06917  84 CEGGSIRTLMRAGpiAERYIAV-----IMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAASLNQNSSKR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIkWTAPEAALYGR-FTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV--ERGYRMPcPQGCPESLHELM 503
Cdd:cd06917 159 STFVGTPY-WMAPEVITEGKyYDTKADIWSLGITTYEMAT-GNPPYSDVDALRAVMLIpkSKPPRLE-GNGYSPLLKEFV 235
                       250
                ....*....|....*
gi 6678617  504 NLCWKKDPDERPTFE 518
Cdd:cd06917 236 AACLDEEPKDRLSAD 250
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
281-522 5.67e-17

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 80.84  E-value: 5.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMG-TWNGTTKVAIK--TLKPGTMM-PEAFLQEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFMSKGSLL 355
Cdd:cd14069   9 LGEGAFGEVFLAvNRNTEEAVAVKfvDMKRAPGDcPENIKKEVCIQKMLSHKNVVRFYGHRREGEFqYLFLEYASGGELF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGkylkLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQGA 430
Cdd:cd14069  89 DKIEPDVG----MPE--DVAqfyfQQLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGLAtVFRYKGKERLLNKM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 KFPIKWTAPE----AALYGRftiKSDVWSFGILQTELVTkGRVPY--PGMVNREVLEQVERGYRMPCP-----QGCPESL 499
Cdd:cd14069 163 CGTLPYVAPEllakKKYRAE---PVDVWSCGIVLFAMLA-GELPWdqPSDSCQEYSDWKENKKTYLTPwkkidTAALSLL 238
                       250       260
                ....*....|....*....|...
gi 6678617  500 HELMnlcwKKDPDERPTFEYIQS 522
Cdd:cd14069 239 RKIL----TENPNKRITIEDIKK 257
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
280-466 5.71e-17

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 81.50  E-value: 5.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKpgtMMPEA--F----LQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFM 349
Cdd:cd07843  12 RIEEGTYGVVYRARDKKTGEiVALKKLK---MEKEKegFpitsLREINILLKLQHPNIVTVKEVVvgsNLDKIYMVMEYV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKgSLLDFLKEGDGKYLkLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN--EYTar 427
Cdd:cd07843  89 EH-DLKSLMETMKQPFL-QSEVKCLMLQLLSGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAREYGSPlkPYT-- 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6678617  428 qgakfPIKWT----APEAAL-YGRFTIKSDVWSFGILQTELVTK 466
Cdd:cd07843 165 -----QLVVTlwyrAPELLLgAKEYSTAIDMWSVGCIFAELLTK 203
SH3_1 pfam00018
SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal ...
95-142 6.39e-17

SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 394975 [Multi-domain]  Cd Length: 47  Bit Score: 74.55  E-value: 6.39e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6678617     95 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIaTGKSGYIPS 142
Cdd:pfam00018   1 VALYDYTAQEPDELSFKKGDIIIVLEKSEDGWWKGRNK-GGKEGLIPS 47
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
281-459 6.42e-17

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 80.50  E-value: 6.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTT-KVAIKTL---KPGTMMPEAFLqEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 355
Cdd:cd14078  11 IGSGGFAKVKLATHILTGeKVAIKIMdkkALGDDLPRVKT-EIEALKNLSHQHICRLYHVIeTDNKIFMVLEYCPGGELF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA----RLIEDNEYTARQGAK 431
Cdd:cd14078  90 DYIVAKD--RLSEDEARVFFRQIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGLCakpkGGMDHHLETCCGSPA 167
                       170       180       190
                ....*....|....*....|....*....|
gi 6678617  432 FpikwTAPEaALYGRFTIKS--DVWSFGIL 459
Cdd:cd14078 168 Y----AAPE-LIQGKPYIGSeaDVWSMGVL 192
SH2_Fps_family cd10361
Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related ...
149-241 6.45e-17

Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins; The Fps family consists of members Fps/Fes and Fer/Flk/Tyk3. They are cytoplasmic protein-tyrosine kinases implicated in signaling downstream from cytokines, growth factors and immune receptors. Fes/Fps/Fer contains three coiled-coil regions, an SH2 (Src-homology-2) and a TK (tyrosine kinase catalytic) domain signature. Members here include: Fps/Fes, Fer, Kin-31, and In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198224  Cd Length: 90  Bit Score: 75.64  E-value: 6.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  149 DSIQAEEWYFGKMGRKDAERLLLNPGNqrgiFLVRESE---TTKGAYSLSIRdWDEvrgdNVKHYKIRKLDNGGYYITTR 225
Cdd:cd10361   1 KDLENEPYYHGLLPREDAEELLKNDGD----FLVRKTEpkgGGKRKLVLSVR-WDG----KIRHFVINRDDGGKYYIEGK 71
                        90
                ....*....|....*.
gi 6678617  226 AqFDTLQKLVKHYTEH 241
Cdd:cd10361  72 S-FKSISELINYYQKT 86
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
281-473 6.67e-17

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 82.12  E-value: 6.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   281 LGQGCFGEVW--MGTWNGTtKVAIKTLKPGTMMPEAF---------------LQEAQIMKKLRHDKLVPLYAV-VSEEPI 342
Cdd:PTZ00024  17 LGEGTYGKVEkaYDTLTGK-IVAIKKVKIIEISNDVTkdrqlvgmcgihfttLRELKIMNEIKHENIMGLVDVyVEGDFI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   343 YIVTEFMSKgsllDFLKEGDGK-YLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR---- 417
Cdd:PTZ00024  96 NLVMDIMAS----DLKKVVDRKiRLTESQVKCILLQILNGLNVLHKWYFMHRDLSPANIFINSKGICKIADFGLARrygy 171
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617   418 -----LIEDNEYTARQ---GAKFPIKWTAPEAALYG--RFTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:PTZ00024 172 ppysdTLSKDETMQRReemTSKVVTLWYRAPELLMGaeKYHFAVDMWSVGCIFAELLT-GKPLFPG 236
SH3_Lyn cd12004
Src homology 3 domain of Lyn Protein Tyrosine Kinase; Lyn is a member of the Src subfamily of ...
93-149 6.84e-17

Src homology 3 domain of Lyn Protein Tyrosine Kinase; Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212937 [Multi-domain]  Cd Length: 56  Bit Score: 74.64  E-value: 6.84e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNtEGDWWEARSIATGKSGYIPSNYVVPAD 149
Cdd:cd12004   1 IVVALYPYDGIHEDDLSFKKGEKLKVIEE-HGEWWKARSLTTKKEGFIPSNYVAKVN 56
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
315-515 7.12e-17

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 80.78  E-value: 7.12e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  315 FLQEAQIMKKLRHDKLVPLYAVvSEEPIYIVTEFMSKGSLLDFLKEG--DGKYLKLPQLV--DMAAQIADGMAYIERMNY 390
Cdd:cd14067  57 FRQEASMLHSLQHPCIVYLIGI-SIHPLCFALELAPLGSLNTVLEENhkGSSFMPLGHMLtfKIAYQIAAGLAYLHKKNI 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  391 IHRDLRAANILV-----GENLICKIADFGLARlieDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVT 465
Cdd:cd14067 136 IFCDLKSDNILVwsldvQEHINIKLSDYGISR---QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 212
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  466 kGRVPYPGMVNREVLEQVERGYRmPCpQGCPES-----LHELMNLCWKKDPDERP 515
Cdd:cd14067 213 -GQRPSLGHHQLQIAKKLSKGIR-PV-LGQPEEvqffrLQALMMECWDTKPEKRP 264
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
279-504 7.20e-17

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 80.94  E-value: 7.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  279 VKLGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKgS 353
Cdd:cd07839   6 EKIGEGTYGTVFKAKNRETHEiVALKRVRlddDDEGVPSSALREICLLKELKHKNIVRLYDVLhSDKKLTLVFEYCDQ-D 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTarqgAK 431
Cdd:cd07839  85 LKKYFDSCNG-DIDPEIVKSFMFQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAfgIPVRCYS----AE 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  432 FPIKWTAPEAALYGR--FTIKSDVWSFGILQTELVTKGRVPYPGmvnREVLEQVERGYRM---PCPQGCPeSLHELMN 504
Cdd:cd07839 160 VVTLWYRPPDVLFGAklYSTSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRLlgtPTEESWP-GVSKLPD 233
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
281-471 8.64e-17

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 80.44  E-value: 8.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTT--KVAIKTLKPGTMMPEAFL--QEAQIMKKLRHDKLVPLYAVvSEEP--IYIVTEFMSKGSL 354
Cdd:cd14201  14 VGHGAFAVVFKGRHRKKTdwEVAIKSINKKNLSKSQILlgKEIKILKELQHENIVALYDV-QEMPnsVFLVMEYCNGGDL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLkEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG---------ENLICKIADFGLARLIEDNEYT 425
Cdd:cd14201  93 ADYL-QAKGT-LSEDTIRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSyasrkkssvSGIRIKIADFGFARYLQSNMMA 170
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  426 ARQGAKfPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd14201 171 ATLCGS-PM-YMAPEVIMSQHYDAKADLWSIGTVIYQCLV-GKPPF 213
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
281-459 9.45e-17

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 80.70  E-value: 9.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd05580   9 LGTGSFGRVRLVKHKDSGKyYALKILKKAKIIKlkqvEHVLNEKRILSEVRHPFIVNLLGSFQDDRnLYMVMEYVPGGEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdgKYLKLPQLVDM--AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTarqgakf 432
Cdd:cd05580  89 FSLLR----RSGRFPNDVAKfyAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRVKDRTYT------- 157
                       170       180       190
                ....*....|....*....|....*....|....
gi 6678617  433 pIKWT----APEAAL---YGRftiKSDVWSFGIL 459
Cdd:cd05580 158 -LCGTpeylAPEIILskgHGK---AVDWWALGIL 187
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
281-516 1.06e-16

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 80.56  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKpgTMMPEAFLQEAQIMKK--LRHDKLVPLYAVVSEE-----PIYIVTEFMSKGS 353
Cdd:cd14143   3 IGKGRFGEVWRGRWRGED-VAVKIFS--SREERSWFREAEIYQTvmLRHENILGFIAADNKDngtwtQLWLVSDYHEHGS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIErMNYI---------HRDLRAANILVGENLICKIADFGLA-RLIE--- 420
Cdd:cd14143  80 LFDYLNR---YTVTVEGMIKLALSIASGLAHLH-MEIVgtqgkpaiaHRDLKSKNILVKKNGTCCIADLGLAvRHDSatd 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 --DNEYTARQGAKfpiKWTAPEaALYGRFTIKS-------DVWSFGILQTELVTKGRV---------PYPGMVNRE-VLE 481
Cdd:cd14143 156 tiDIAPNHRVGTK---RYMAPE-VLDDTINMKHfesfkraDIYALGLVFWEIARRCSIggihedyqlPYYDLVPSDpSIE 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  482 QV-----ERGYRMPCP---QGCpESLH---ELMNLCWKKDPDERPT 516
Cdd:cd14143 232 EMrkvvcEQKLRPNIPnrwQSC-EALRvmaKIMRECWYANGAARLT 276
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
281-518 1.20e-16

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 79.72  E-value: 1.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK--VAIKTL-KPGTMMPEAFL-QEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLL 355
Cdd:cd14120   1 IGHGAFAVVFKGRHRKKPDlpVAIKCItKKNLSKSQNLLgKEIKILKELSHENVVALLDCqETSSSVYLVMEYCNGGDLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFL-KEGDgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---------GENLICKIADFGLARLIEDNEYT 425
Cdd:cd14120  81 DYLqAKGT---LSEDTIRVFLQQIAAAMKALHSKGIVHRDLKPQNILLshnsgrkpsPNDIRLKIADFGFARFLQDGMMA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQ-GAkfPIkWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYR-MP-CPQGCPESLHEL 502
Cdd:cd14120 158 ATLcGS--PM-YMAPEVIMSLQYDAKADLWSIGTIVYQCLT-GKAPFQAQTPQELKAFYEKNANlRPnIPSGTSPALKDL 233
                       250
                ....*....|....*.
gi 6678617  503 MNLCWKKDPDERPTFE 518
Cdd:cd14120 234 LLGLLKRNPKDRIDFE 249
SH2_C-SH2_SHP_like cd09931
C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; The ...
156-241 1.23e-16

C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; The SH2 domain phosphatases (SHP-1, SHP-2/Syp, Drosophila corkscrew (csw), and Caenorhabditis elegans Protein Tyrosine Phosphatase (Ptp-2)) are cytoplasmic signaling enzymes. They are both targeted and regulated by interactions of their SH2 domains with phosphotyrosine docking sites. These proteins contain two SH2 domains (N-SH2, C-SH2) followed by a tyrosine phosphatase (PTP) domain, and a C-terminal extension. Shp1 and Shp2 have two tyrosyl phosphorylation sites in their C-tails, which are phosphorylated differentially by receptor and nonreceptor PTKs. Csw retains the proximal tyrosine and Ptp-2 lacks both sites. Shp-binding proteins include receptors, scaffolding adapters, and inhibitory receptors. Some of these bind both Shp1 and Shp2 while others bind only one. Most proteins that bind a Shp SH2 domain contain one or more immuno-receptor tyrosine-based inhibitory motifs (ITIMs): [SIVL]xpYxx[IVL]. Shp1 N-SH2 domain blocks the catalytic domain and keeps the enzyme in the inactive conformation, and is thus believed to regulate the phosphatase activity of SHP-1. Its C-SH2 domain is thought to be involved in searching for phosphotyrosine activators. The SHP2 N-SH2 domain is a conformational switch; it either binds and inhibits the phosphatase, or it binds phosphoproteins and activates the enzyme. The C-SH2 domain contributes binding energy and specificity, but it does not have a direct role in activation. Csw SH2 domain function is essential, but either SH2 domain can fulfill this requirement. The role of the csw SH2 domains during Sevenless receptor tyrosine kinase (SEV) signaling is to bind Daughter of Sevenless rather than activated SEV. Ptp-2 acts in oocytes downstream of sheath/oocyte gap junctions to promote major sperm protein (MSP)-induced MAP Kinase (MPK-1) phosphorylation. Ptp-2 functions in the oocyte cytoplasm, not at the cell surface to inhibit multiple RasGAPs, resulting in sustained Ras activation. It is thought that MSP triggers PTP-2/Ras activation and ROS production to stimulate MPK-1 activity essential for oocyte maturation and that secreted MSP domains and Cu/Zn superoxide dismutases function antagonistically to control ROS and MAPK signaling. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198185  Cd Length: 99  Bit Score: 75.39  E-value: 1.23e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGnQRGIFLVRESETTKGAYSLSIRdwdeVRGDNVKHYKIRkLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd09931   2 WFHGHLSGKEAEKLLLEKG-KPGSFLVRESQSKPGDFVLSVR----TDDDKVTHIMIR-CQGGKYDVGGGEEFDSLTDLV 75

                ....*.
gi 6678617  236 KHYTEH 241
Cdd:cd09931  76 EHYKKN 81
PTK_Tyk2_rpt1 cd05076
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is ...
299-520 1.38e-16

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270661 [Multi-domain]  Cd Length: 273  Bit Score: 79.95  E-value: 1.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  299 KVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI-VTEFMSKGSLLDFLKEGDGKyLKLPQLVDMAA 376
Cdd:cd05076  45 RVVLKVLDPSHHdIALAFFETASLMSQVSHTHLVFVHGVCVRGSENImVEEFVEHGPLDVWLRKEKGH-VPMAWKFVVAR 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  377 QIADGMAYIERMNYIHRDLRAANILV-------GENLICKIADFGLARLIEDNEYTARQgakfpIKWTAPEAALYG-RFT 448
Cdd:cd05076 124 QLASALSYLENKNLVHGNVCAKNILLarlgleeGTSPFIKLSDPGVGLGVLSREERVER-----IPWIAPECVPGGnSLS 198
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6678617  449 IKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQgCPEsLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd05076 199 TAADKWGFGATLLEICFNGEAPLQSRTPSEKERFYQRQHRLPEPS-CPE-LATLISQCLTYEPTQRPSFRTI 268
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
273-520 1.45e-16

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 79.68  E-value: 1.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMgTWNGTT--KVAIKTL--KPGTMMPE----AFLQEAQIMKKLRHDKLVPLYAVV---SEEP 341
Cdd:cd06653   2 VNWRLGKLLGRGAFGEVYL-CYDADTgrELAVKQVpfDPDSQETSkevnALECEIQLLKNLRHDRIVQYYGCLrdpEEKK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDFLKegdgKYLKLPQLVD--MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI 419
Cdd:cd06653  81 LSIFVEYMPGGSVKDQLK----AYGALTENVTrrYTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 ED--NEYTARQGAKFPIKWTAPEAAL---YGRftiKSDVWSFGILQTELVTKGrvpyPGMVNREVLEQVERGYRMPC--- 491
Cdd:cd06653 157 QTicMSGTGIKSVTGTPYWMSPEVISgegYGR---KADVWSVACTVVEMLTEK----PPWAEYEAMAAIFKIATQPTkpq 229
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  492 -PQGCPESLHELMN--LCWKKdpdERPTFEYI 520
Cdd:cd06653 230 lPDGVSDACRDFLRqiFVEEK---RRPTAEFL 258
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
281-463 1.63e-16

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 80.05  E-value: 1.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVA-IKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY--AVVSEEP------IYIVTEFMSK 351
Cdd:cd06636  24 VGNGTYGQVYKGRHVKTGQLAaIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYygAFIKKSPpghddqLWLVMEFCGA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDNEYTARQGAK 431
Cdd:cd06636 104 GSVTDLVKNTKGNALKEDWIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGRRNTFI 182
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6678617  432 FPIKWTAPEAALY-----GRFTIKSDVWSFGILQTEL 463
Cdd:cd06636 183 GTPYWMAPEVIACdenpdATYDYRSDIWSLGITAIEM 219
SH3 cd00174
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
93-144 1.76e-16

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


Pssm-ID: 212690 [Multi-domain]  Cd Length: 51  Bit Score: 73.27  E-value: 1.76e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARsIATGKSGYIPSNY 144
Cdd:cd00174   1 YARALYDYEAQDDDELSFKKGDIITVLEKDDDGWWEGE-LNGGREGLFPANY 51
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
275-485 2.25e-16

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 79.62  E-value: 2.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEvKLGQGCFGEVWMGT--WNGTTkVAIK--TLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFM 349
Cdd:cd07870   3 LNLE-KLGEGSYATVYKGIsrINGQL-VALKviSMKTEEGVPFTAIREASLLKGLKHANIVLLHDIIhTKETLTFVFEYM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKgSLLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTar 427
Cdd:cd07870  81 HT-DLAQYMIQHPGG-LHPYNVRLFMFQLLRGLAYIHGQHILHRDLKPQNLLISYLGELKLADFGLARAksIPSQTYS-- 156
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 qgAKFPIKWTAPEAALYG--RFTIKSDVWSFGILQTELVtKGRVPYPGMVNreVLEQVER 485
Cdd:cd07870 157 --SEVVTLWYRPPDVLLGatDYSSALDIWGAGCIFIEML-QGQPAFPGVSD--VFEQLEK 211
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
266-528 2.82e-16

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 79.28  E-value: 2.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPReslrlevKLGQGCFGEVW--MGTWNGTtKVAIKTLKPGTMMPEAFLQEAQIMKKLR-HDKLVPLYA------V 336
Cdd:cd06638  18 DTWEIIE-------TIGKGTYGKVFkvLNKKNGS-KAAVKILDPIHDIDEEIEAEYNILKALSdHPNVVKFYGmyykkdV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEEPIYIVTEFMSKGSLLD----FLKEGDgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIAD 412
Cdd:cd06638  90 KNGDQLWLVLELCNGGSVTDlvkgFLKRGE--RMEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNILLTTEGGVKLVD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  413 FGLARLIEDNEYTARQGAKFPIkWTAPEA-----ALYGRFTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERG- 486
Cdd:cd06638 168 FGVSAQLTSTRLRRNTSVGTPF-WMAPEViaceqQLDSTYDARCDVWSLGITAIEL-GDGDPPLADLHPMRALFKIPRNp 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6678617  487 -YRMPCPQGCPESLHELMNLCWKKDPDERPTfeyIQSFLEDYF 528
Cdd:cd06638 246 pPTLHQPELWSNEFNDFIRKCLTKDYEKRPT---VSDLLQHVF 285
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
281-520 3.58e-16

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 78.62  E-value: 3.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd08220   8 VGRGAYGTVYLCRRKDDNKlVIIKQIPVEQMTKEerqAALNEVKVLSMLHHPNIIEYYeSFLEDKALMIVMEYAPGGTLF 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN-LICKIADFGLARLIedneyTARQGAKFPI 434
Cdd:cd08220  88 EYIQQRKGSLLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNKKrTVVKIGDFGISKIL-----SSKSKAYTVV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 K---WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRV----PYPGMVNRevleqVERGYRMPCPQGCPESLHELMNLCW 507
Cdd:cd08220 163 GtpcYISPELCEGKPYNQKSDIWALGCVLYELASLKRAfeaaNLPALVLK-----IMRGTFAPISDRYSEELRHLILSML 237
                       250
                ....*....|...
gi 6678617  508 KKDPDERPTFEYI 520
Cdd:cd08220 238 HLDPNKRPTLSEI 250
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
281-514 3.68e-16

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 78.42  E-value: 3.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKP----GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSL 354
Cdd:cd05572   1 LGVGGFGRVELVQLKSKGRTfALKCVKKrhivQTRQQEHIFSEKEILEECNSPFIVKLYRTFKdKKYLYMLMEYCLGGEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLK------EGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTarq 428
Cdd:cd05572  81 WTILRdrglfdEYTARFY--------TACVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGRKT--- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 gakfpikWT--------APEAALYGRFTIKSDVWSFGILQTELVTkGRVPY------PGMVNREVLEQVergYRMPCPQG 494
Cdd:cd05572 150 -------WTfcgtpeyvAPEIILNKGYDFSVDYWSLGILLYELLT-GRPPFggddedPMKIYNIILKGI---DKIEFPKY 218
                       250       260
                ....*....|....*....|.
gi 6678617  495 CPESLHELMN-LCwKKDPDER 514
Cdd:cd05572 219 IDKNAKNLIKqLL-RRNPEER 238
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
272-518 3.73e-16

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 78.88  E-value: 3.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQ-EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEF 348
Cdd:cd14166   2 RETFIFMEVLGSGAFSEVYLVKQRSTGKLyALKCIKKSPLSRDSSLEnEIAVLKRIKHENIVTLEDIYeSTTHYYLVMQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSKGSLLDFLKEgDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLIEDNEYT 425
Cdd:cd14166  82 VSGGELFDRILE-RGVYTE-KDASRVINQVLSAVKYLHENGIVHRDLKPENLLYltpDENSKIMITDFGLSKMEQNGIMS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYPGMVNREVLEQVERGY---RMPCPQGCPESLHEL 502
Cdd:cd14166 160 TACGTP---GYVAPEVLAQKPYSKAVDCWSIGVI-TYILLCGYPPFYEETESRLFEKIKEGYyefESPFWDDISESAKDF 235
                       250
                ....*....|....*.
gi 6678617  503 MNLCWKKDPDERPTFE 518
Cdd:cd14166 236 IRHLLEKNPSKRYTCE 251
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
277-490 3.91e-16

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 78.28  E-value: 3.91e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGTT-KVAIKTL---KPGTMMPEAFL-QEAQIMKKLRHDKLVPLYAV--VSEEPIYIVTEFM 349
Cdd:cd14165   5 LGINLGEGSYAKVKSAYSERLKcNVAIKIIdkkKAPDDFVEKFLpRELEILARLNHKSIIKTYEIfeTSDGKVYIVMELG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGdgkyLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNEYTA 426
Cdd:cd14165  85 VQGDLLEFIKLR----GALPEDVarKMFHQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRCLrDENGRI 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  427 RQGAKF--PIKWTAPEAALYGRFTIK-SDVWSFGILQTELVTkGRVPYPGMVNREVL-EQVERGYRMP 490
Cdd:cd14165 161 VLSKTFcgSAAYAAPEVLQGIPYDPRiYDIWSLGVILYIMVC-GSMPYDDSNVKKMLkIQKEHRVRFP 227
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
281-530 4.28e-16

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 78.96  E-value: 4.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEA--FLQEAQIMKKlRHD--KLVPLY-AVVSEEPIYIVTEFMSkgSL 354
Cdd:cd06618  23 IGSGTCGQVYKMRHKKTGHVmAVKQMRRSGNKEENkrILMDLDVVLK-SHDcpYIVKCYgYFITDSDVFICMELMS--TC 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYI-ERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQGAKf 432
Cdd:cd06618 100 LDKLLKRIQGPIPEDILGKMTVSIVKALHYLkEKHGVIHRDVKPSNILLDESGNVKLCDFGISgRLVDSKAKTRSAGCA- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 piKWTAPE---AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-EVLEQV--ERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd06618 179 --AYMAPEridPPDNPKYDIRADVWSLGISLVELAT-GQFPYRNCKTEfEVLTKIlnEEPPSLPPNEGFSPDFCSFVDLC 255
                       250       260
                ....*....|....*....|....*.
gi 6678617  507 WKKDPDERPTFEYI--QSFLEDYFTA 530
Cdd:cd06618 256 LTKDHRYRPKYRELlqHPFIRRYETA 281
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
280-496 4.74e-16

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 78.89  E-value: 4.74e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKgSLL 355
Cdd:cd07873   9 KLGEGTYATVYKGRSKLTDNlVALKEirLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIhTEKSLTLVFEYLDK-DLK 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGdGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYTarqgAKFP 433
Cdd:cd07873  88 QYLDDC-GNSINMHNVKLFLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAksIPTKTYS----NEVV 162
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  434 IKWTAPEAALYG--RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCP 496
Cdd:cd07873 163 TLWYRPPDILLGstDYSTQIDMWGVGCIFYEMST-GRPLFPGSTVEEQLHFIFRILGTPTEETWP 226
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
281-516 4.88e-16

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 78.94  E-value: 4.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKPGTMmpEAFLQEAQIMK--KLRHDKLVPLYAvvSEEPIY--------IVTEFMS 350
Cdd:cd14054   3 IGQGRYGTVWKGSLDERP-VAVKVFPARHR--QNFQNEKDIYElpLMEHSNILRFIG--ADERPTadgrmeylLVLEYAP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKEGDgkyLKLPQLVDMAAQIADGMAYI---ERMNYI------HRDLRAANILVGENLICKIADFGLARLIED 421
Cdd:cd14054  78 KGSLCSYLRENT---LDWMSSCRMALSLTRGLAYLhtdLRRGDQykpaiaHRDLNSRNVLVKADGSCVICDFGLAMVLRG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTARQ-GAKFP--------IKWTAPE---AAL----YGRFTIKSDVWSFGILQTELVTKGRVPYPGMV---------- 475
Cdd:cd14054 155 SSLVRGRpGAAENasisevgtLRYMAPEvleGAVnlrdCESALKQVDVYALGLVLWEIAMRCSDLYPGESvppyqmpyea 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  476 ---NREVLEQ----VERGYRMPC-PQGCPE------SLHELMNLCWKKDPDERPT 516
Cdd:cd14054 235 elgNHPTFEDmqllVSREKARPKfPDAWKEnslavrSLKETIEDCWDQDAEARLT 289
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
271-516 5.78e-16

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 78.54  E-value: 5.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLK-PGTMMPEAFLQEAQIMKKLRHDKLVPLYA--VVSEEpIYIVT 346
Cdd:cd06658  20 PREYLDSFIKIGEGSTGIVCIATEKHTGKqVAVKKMDlRKQQRRELLFNEVVIMRDYHHENVVDMYNsyLVGDE-LWVVM 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEdNEYTA 426
Cdd:cd06658  99 EFLEGGALTDIVTH---TRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVS-KEVPK 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmVNREVLEQVERgYRMPCPQGCPES------LH 500
Cdd:cd06658 175 RKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMI-DGEPPY---FNEPPLQAMRR-IRDNLPPRVKDShkvssvLR 249
                       250
                ....*....|....*.
gi 6678617  501 ELMNLCWKKDPDERPT 516
Cdd:cd06658 250 GFLDLMLVREPSQRAT 265
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
271-471 5.94e-16

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 78.49  E-value: 5.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKtlkpgtMMP-------EAFLQEAQIMKKLRHDKLVPLY--AVVSEE 340
Cdd:cd06659  19 PRQLLENYVKIGEGSTGVVCIAREKHSGRqVAVK------MMDlrkqqrrELLFNEVVIMRDYQHPNVVEMYksYLVGEE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 pIYIVTEFMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE 420
Cdd:cd06659  93 -LWVLMEYLQGGALTDIVSQ---TRLNEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQIS 168
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  421 DNEYTARQGAKFPIkWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPY 471
Cdd:cd06659 169 KDVPKRKSLVGTPY-WMAPEVISRCPYGTEVDIWSLGIMVIEMV-DGEPPY 217
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
281-514 6.84e-16

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 78.60  E-value: 6.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM-----GTWNGTTkVAIKTLKPGTMMPEAFLQ---EAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSK 351
Cdd:cd05582   3 LGQGSFGKVFLvrkitGPDAGTL-YAMKVLKKATLKVRDRVRtkmERDILADVNHPFIVKLhYAFQTEGKLYLILDFLRG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLK------EGDGK-YLklpqlvdmaAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd05582  82 GDLFTRLSkevmftEEDVKfYL---------AELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHEK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQgakF--PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGyRMPCPQGCPESLHEL 502
Cdd:cd05582 153 KAYS---FcgTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GSLPFQGKDRKETMTMILKA-KLGMPQFLSPEAQSL 227
                       250
                ....*....|..
gi 6678617  503 MNLCWKKDPDER 514
Cdd:cd05582 228 LRALFKRNPANR 239
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
315-516 6.99e-16

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 78.49  E-value: 6.99e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  315 FLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLKE--GDGkylkLPQLVdmAAQI----ADGMAYIER 387
Cdd:cd08216  46 LQQEILTSRQLQHPNILPYVTSfVVDNDLYVVTPLMAYGSCRDLLKThfPEG----LPELA--IAFIlrdvLNALEYIHS 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  388 MNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNEYTAR-----QGAKFPIKWTAPEA---ALYGrFTIKSDVWSFGI 458
Cdd:cd08216 120 KGYIHRSVKASHILISGDGKVVLSGLRYAYsMVKHGKRQRVvhdfpKSSEKNLPWLSPEVlqqNLLG-YNEKSDIYSVGI 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  459 LQTELvTKGRVPYPGMVNREVLEQVERGYrMPCPQGC-----------------------------------PESLHELM 503
Cdd:cd08216 199 TACEL-ANGVVPFSDMPATQMLLEKVRGT-TPQLLDCstypleedsmsqsedsstehpnnrdtrdipyqrtfSEAFHQFV 276
                       250
                ....*....|...
gi 6678617  504 NLCWKKDPDERPT 516
Cdd:cd08216 277 ELCLQRDPELRPS 289
SH2_Cterm_RasGAP cd10354
C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP); RasGAP ...
155-238 7.00e-16

C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP); RasGAP is part of the GAP1 family of GTPase-activating proteins. The protein is located in the cytoplasm and stimulates the GTPase activity of normal RAS p21, but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in RAS inactivation, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms. The shorter isoform which lacks the N-terminal hydrophobic region, has the same activity, and is expressed in placental tissues. In general longer isoform contains 2 SH2 domains, a SH3 domain, a pleckstrin homology (PH) domain, and a calcium-dependent phospholipid-binding C2 domain. The C-terminus contains the catalytic domain of RasGap which catalyzes the activation of Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. This model contains the C-terminal SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198217  Cd Length: 77  Bit Score: 72.46  E-value: 7.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLNPGnQRGIFLVRESETTKGAYSLSIRdwdevRGDNVKHYKIRKLDNGGYYITTRAqFDTLQKL 234
Cdd:cd10354   1 IWFHGKISREEAYNMLVKVG-GPGSFLVRESDNTPGDYSLSFR-----VNEGIKHFKIIPTGNNQFMMGGRY-FSSLDDV 73

                ....
gi 6678617  235 VKHY 238
Cdd:cd10354  74 IDRY 77
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
276-473 7.00e-16

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 78.10  E-value: 7.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEvKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTM---MPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd07835   3 KLE-KIGEGTYGVVYKARDKLTGEiVALKKIRLETEdegVPSTAIREISLLKELNHPNIVRLLDVVhSENKLYLVFEFLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 kgslLDFLKEGDGKYL--KLPQLVDM-AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL--IEDNEYT 425
Cdd:cd07835  82 ----LDLKKYMDSSPLtgLDPPLIKSyLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGALKLADFGLARAfgVPVRTYT 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 arqgAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILQTELVTKgRVPYPG 473
Cdd:cd07835 158 ----HEVVTLWyRAPEILLGSKhYSTPVDIWSVGCIFAEMVTR-RPLFPG 202
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
275-528 7.02e-16

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 77.74  E-value: 7.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGTT-KVA---IKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-----AVVSEEPIYIV 345
Cdd:cd14033   3 LKFNIEIGRGSFKTVYRGLDTETTvEVAwceLQTRKLSKGERQRFSEEVEMLKGLQHPNIVRFYdswksTVRGHKCIILV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEgdGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILV-GENLICKIADFGLARLIEDN 422
Cdd:cd14033  83 TELMTSGTLKTYLKR--FREMKLKLLQRWSRQILKGLHFLHSRCppILHRDLKCDNIFItGPTGSVKIGDLGLATLKRAS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARQGAKfpiKWTAPEaaLY-GRFTIKSDVWSFGILQTELVTKgRVPYPGMVN-REVLEQVERG------YRMPCPQg 494
Cdd:cd14033 161 FAKSVIGTP---EFMAPE--MYeEKYDEAVDVYAFGMCILEMATS-EYPYSECQNaAQIYRKVTSGikpdsfYKVKVPE- 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  495 cpesLHELMNLCWKKDPDERPTfeyIQSFLEDYF 528
Cdd:cd14033 234 ----LKEIIEGCIRTDKDERFT---IQDLLEHRF 260
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
281-528 7.88e-16

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 77.73  E-value: 7.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGT-WNGTTKV--AIKTL--KPGTMMPEAF----LQEAQIMKKLRHDKLVP-LYAVVSEEP-IYIVTEFM 349
Cdd:cd13994   1 IGKGATSVVRIVTkKNPRSGVlyAVKEYrrRDDESKRKDYvkrlTSEYIISSKLHHPNIVKvLDLCQDLHGkWCLVMEYC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGDGkylklPQLVDMAA---QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYT 425
Cdd:cd13994  81 PGGDLFTLIEKADS-----LSLEEKDCffkQILRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGTAeVFGMPAEKE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 AR--QGAKFPIKWTAPEAALYGRFTIKS-DVWSFGILQTELVTkGRVPYPGMVNREVL----EQVERGYRMPCPQGCPES 498
Cdd:cd13994 156 SPmsAGLCGSEPYMAPEVFTSGSYDGRAvDVWSCGIVLFALFT-GRFPWRSAKKSDSAykayEKSGDFTNGPYEPIENLL 234
                       250       260       270
                ....*....|....*....|....*....|...
gi 6678617  499 LHELMNLCWK---KDPDERPTfeyIQSFLEDYF 528
Cdd:cd13994 235 PSECRRLIYRmlhPDPEKRIT---IDEALNDPW 264
STKc_BMPR1b cd14219
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs ...
273-516 7.93e-16

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1b, also called Activin receptor-Like Kinase 6 (ALK6), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Mutations in BMPR1b that led to inhibition of chondrogenesis can cause Brachydactyly (BD) type A2, a dominant hand malformation characterized by shortening and lateral deviation of the index fingers. A point mutation in the BMPR1b kinase domain is also associated with the Booroola phenotype, characterized by precocious differentiation of ovarian follicles. BMPR1b belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1b, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271121 [Multi-domain]  Cd Length: 305  Bit Score: 78.17  E-value: 7.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTtKVAIKTLKpgTMMPEAFLQEAQIMKK--LRHDKLVPLYA-----VVSEEPIYIV 345
Cdd:cd14219   5 KQIQMVKQIGKGRYGEVWMGKWRGE-KVAVKVFF--TTEEASWFRETEIYQTvlMRHENILGFIAadikgTGSWTQLYLI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKegdGKYLKLPQLVDMAAQIADGMAYIE--------RMNYIHRDLRAANILVGENLICKIADFGLA- 416
Cdd:cd14219  82 TDYHENGSLYDYLK---STTLDTKAMLKLAYSSVSGLCHLHteifstqgKPAIAHRDLKSKNILVKKNGTCCIADLGLAv 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLIED-NEY----TARQGAKfpiKWTAPEA------ALYGRFTIKSDVWSFGILQTE---------LVTKGRVPY----P 472
Cdd:cd14219 159 KFISDtNEVdippNTRVGTK---RYMPPEVldeslnRNHFQSYIMADMYSFGLILWEvarrcvsggIVEEYQLPYhdlvP 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  473 GMVNREVLEQVE--RGYRMPCPQ-----GCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14219 236 SDPSYEDMREIVciKRLRPSFPNrwssdECLRQMGKLMTECWAHNPASRLT 286
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
280-514 8.06e-16

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 77.72  E-value: 8.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMmPEaFLQEAQIMKKLRHDKLVPLYA-VVSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14010   7 EIGRGKHSVVYKGRRKGTIEfVAIKCVDKSKR-PE-VLNEVRLTHELKHPNVLKFYEwYETSNHLWLVVEYCTGGDLETL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEgDGKylkLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN----------EYT 425
Cdd:cd14010  85 LRQ-DGN---LPESSvrKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLARREGEIlkelfgqfsdEGN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFPIK-----WTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV-ERGYRMPCPQ---GCP 496
Cdd:cd14010 161 VNKVSKKQAKrgtpyYMAPELFQGGVHSFASDLWALGCVLYEMFT-GKPPFVAESFTELVEKIlNEDPPPPPPKvssKPS 239
                       250
                ....*....|....*...
gi 6678617  497 ESLHELMNLCWKKDPDER 514
Cdd:cd14010 240 PDFKSLLKGLLEKDPAKR 257
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
317-483 8.70e-16

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 77.75  E-value: 8.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDL 395
Cdd:cd14194  57 REVSILKEIQHPNVITLHEVYeNKTDVILILELVAGGELFDFLAEKES--LTEEEATEFLKQILNGVYYLHSLQIAHFDL 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  396 RAANILVGENLI----CKIADFGLARLIE-DNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVP 470
Cdd:cd14194 135 KPENIMLLDRNVpkprIKIIDFGLAHKIDfGNEFKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGVI-TYILLSGASP 210
                       170
                ....*....|...
gi 6678617  471 YPGMVNREVLEQV 483
Cdd:cd14194 211 FLGDTKQETLANV 223
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
281-514 8.84e-16

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 77.57  E-value: 8.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTL-------KPGTMMPeafLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSK 351
Cdd:cd05577   1 LGRGGFGEVCACQVKATGKMyACKKLdkkrikkKKGETMA---LNEKIILEKVSSPFIVSLaYAFETKDKLCLVLTLMNG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQGA 430
Cdd:cd05577  78 GDLKYHIYNVGTRGFSEARAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAvEFKGGKKIKGRVGT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  431 kfpIKWTAPEAALYGR-FTIKSDVWSFGILQTELVtKGRVP---YPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd05577 158 ---HGYMAPEVLQKEVaYDFSVDWFALGCMLYEMI-AGRSPfrqRKEKVDKEELKRRTLEMAVEYPDSFSPEARSLCEGL 233

                ....*...
gi 6678617  507 WKKDPDER 514
Cdd:cd05577 234 LQKDPERR 241
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
280-515 9.79e-16

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 77.16  E-value: 9.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPEAFL-----QEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKG 352
Cdd:cd14070   9 KLGEGSFAKVREGLHAVTgEKVAIKVIDKKKAKKDSYVtknlrREGRIQQMIRHPNITQLLDILeTENSYYLVMELCPGG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDflKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR----LIEDNEYTARQ 428
Cdd:cd14070  89 NLMH--RIYDKKRLEEREARRYIRQLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLSNcagiLGYSDPFSTQC 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY---PGMVnREVLEQVERGYRMPCPQGCPESLHELMNL 505
Cdd:cd14070 167 GSP---AYAAPELLARKKYGPKVDVWSIGVNMYAMLT-GTLPFtvePFSL-RALHQKMVDKEMNPLPTDLSPGAISFLRS 241
                       250
                ....*....|
gi 6678617  506 CWKKDPDERP 515
Cdd:cd14070 242 LLEPDPLKRP 251
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
281-459 9.96e-16

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 77.52  E-value: 9.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMG------TWNGTTKVAIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFM 349
Cdd:cd14076   9 LGEGEFGKVKLGwplpkaNHRSGVQVAIKLIRRDTQQENCqtskIMREINILKGLTHPNIVRLLDVLkTKKYIGIVLEFV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLArliedNEYTARQG 429
Cdd:cd14076  89 SGGELFDYILAR--RRLKDSVACRLFAQLISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFA-----NTFDHFNG 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6678617  430 AKFPIK-----WTAPE-----AALYGRftiKSDVWSFGIL 459
Cdd:cd14076 162 DLMSTScgspcYAAPElvvsdSMYAGR---KADIWSCGVI 198
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
276-466 1.00e-15

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 77.39  E-value: 1.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMgTWNGTT--KVAIKTLKPGTMMPE------AFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYI 344
Cdd:cd06652   5 RLGKLLGQGAFGRVYL-CYDADTgrELAVKQVQFDPESPEtskevnALECEIQLLKNLLHERIVQYYGCLrdpQERTLSI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDFLKEgdgkYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd06652  84 FMEYMPGGSIKDQLKS----YGALTENVtrKYTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASKRLQTI 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6678617  423 --EYTARQGAKFPIKWTAPEAAL---YGRftiKSDVWSFGILQTELVTK 466
Cdd:cd06652 160 clSGTGMKSVTGTPYWMSPEVISgegYGR---KADIWSVGCTVVEMLTE 205
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
299-473 1.02e-15

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 78.67  E-value: 1.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  299 KVAIK--TLKPGTMMPEAfLQEAQIMKKLRHDKLVPLYAV---------------VSEEPIYIVTEFMSKgSLLDFLKEG 361
Cdd:cd07854  32 RVAVKkiVLTDPQSVKHA-LREIKIIRRLDHDNIVKVYEVlgpsgsdltedvgslTELNSVYIVQEYMET-DLANVLEQG 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  362 --DGKYLKLpqlvdMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLICKIADFGLARlIEDNEYTAR----QGakFPI 434
Cdd:cd07854 110 plSEEHARL-----FMYQLLRGLKYIHSANVLHRDLKPANVFINtEDLVLKIGDFGLAR-IVDPHYSHKgylsEG--LVT 181
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6678617  435 KW-TAPEAALYGR-FTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd07854 182 KWyRSPRLLLSPNnYTKAIDMWAAGCIFAEMLT-GKPLFAG 221
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
280-480 1.05e-15

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 78.03  E-value: 1.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG--TWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKL----RHDK--LVPLYAVVS-EEPIYIVTEFMS 350
Cdd:cd14135   7 YLGKGVFSNVVRArdLARGNQEVAIKIIRNNELMHKAGLKELEILKKLndadPDDKkhCIRLLRHFEhKNHLCLVFESLS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 kGSLLDFLKE-GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGEN-LICKIADFGLARLIEDNEYTARQ 428
Cdd:cd14135  87 -MNLREVLKKyGKNVGLNIKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNEKkNTLKLCDFGSASDIGENEITPYL 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617  429 GAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVL 480
Cdd:cd14135 166 VSRF---YRAPEIILGLPYDYPIDMWSVGCTLYELYT-GKILFPGKTNNHML 213
SH2_N-SH2_Zap70_Syk_like cd09938
N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 ...
156-259 1.08e-15

N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; ZAP-70 and Syk comprise a family of hematopoietic cell specific protein tyrosine kinases (PTKs) that are required for antigen and antibody receptor function. ZAP-70 is expressed in T and natural killer (NK) cells and Syk is expressed in B cells, mast cells, polymorphonuclear leukocytes, platelets, macrophages, and immature T cells. They are required for the proper development of T and B cells, immune receptors, and activating NK cells. They consist of two N-terminal Src homology 2 (SH2) domains and a C-terminal kinase domain separated from the SH2 domains by a linker or hinge region. Phosphorylation of both tyrosine residues within the Immunoreceptor Tyrosine-based Activation Motifs (ITAM; consensus sequence Yxx[LI]x(7,8)Yxx[LI]) by the Src-family PTKs is required for efficient interaction of ZAP-70 and Syk with the receptor subunits and for receptor function. ZAP-70 forms two phosphotyrosine binding pockets, one of which is shared by both SH2 domains. In Syk the two SH2 domains do not form such a phosphotyrosine-binding site. The SH2 domains here are believed to function independently. In addition, the two SH2 domains of Syk display flexibility in their relative orientation, allowing Syk to accommodate a greater variety of spacing sequences between the ITAM phosphotyrosines and singly phosphorylated non-classical ITAM ligands. This model contains the N-terminus SH2 domains of both Syk and Zap70. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198191  Cd Length: 104  Bit Score: 72.81  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIrdwdeVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd09938   3 FFYGSITREEAEEYLKLAGMSDGLFLLRQSLRSLGGYVLSV-----CHGRKFHHYTIERQLNGTYAIAGGKAHCGPAELC 77
                        90       100
                ....*....|....*....|....*..
gi 6678617  236 KHYTEHADGLCHKLTTVC---PTVKPQ 259
Cdd:cd09938  78 EYHSTDLDGLVCLLRKPCnrpPGVEPK 104
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
316-518 1.16e-15

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 77.08  E-value: 1.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKLRHDKLVPLYA-VVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 394
Cdd:cd08221  47 LNEIDILSLLNHDNIITYYNhFLDGESLFIEMEYCNGGNLHDKIAQQKNQLFPEEVVLWYLYQIVSAVSHIHKAGILHRD 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  395 LRAANILVGENLICKIADFGLARLIeDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM 474
Cdd:cd08221 127 IKTLNIFLTKADLVKLGDFGISKVL-DSESSMAESIVGTPYYMSPELVQGVKYNFKSDIWAVGCVLYELLTLKRTFDATN 205
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6678617  475 VNREVLEQVERGYRMPCPQgCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd08221 206 PLRLAVKIVQGEYEDIDEQ-YSEEIIQLVHDCLHQDPEDRPTAE 248
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
281-516 1.16e-15

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 77.87  E-value: 1.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTkVAIKTLKpgTMMPEAFLQEAQIMKK--LRHDKLVPLYAV-----VSEEPIYIVTEFMSKGS 353
Cdd:cd14142  13 IGKGRYGEVWRGQWQGES-VAVKIFS--SRDEKSWFRETEIYNTvlLRHENILGFIASdmtsrNSCTQLWLITHYHENGS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDgkyLKLPQLVDMAAQIADGMAYIE--------RMNYIHRDLRAANILVGENLICKIADFGLARL------I 419
Cdd:cd14142  90 LYDYLQRTT---LDHQEMLRLALSAASGLVHLHteifgtqgKPAIAHRDLKSKNILVKSNGQCCIADLGLAVThsqetnQ 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  420 EDNEYTARQGAKfpiKWTAPEA----------ALYGRftikSDVWSFGILQTE---------LVTKGRVPYPGMVN---- 476
Cdd:cd14142 167 LDVGNNPRVGTK---RYMAPEVldetintdcfESYKR----VDIYAFGLVLWEvarrcvsggIVEEYKPPFYDVVPsdps 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6678617  477 ----REVLeqVERGYRMPCPQGCPE-----SLHELMNLCWKKDPDERPT 516
Cdd:cd14142 240 fedmRKVV--CVDQQRPNIPNRWSSdptltAMAKLMKECWYQNPSARLT 286
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
281-483 1.18e-15

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 77.92  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMM--PEAFLQEAQIMKKLRHDKLVPLYAVVSEEPI---YIVTEFMSKGSL 354
Cdd:cd13988   1 LGQGATANVFRGRHKKTGDlYAVKVFNNLSFMrpLDVQMREFEVLKKLNHKNIVKLFAIEEELTTrhkVLVMELCPCGSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGDGKYlKLPQ--LVDMAAQIADGMAYIERMNYIHRDLRAANIL--VGENLIC--KIADFGLARLIEDNE-YTAR 427
Cdd:cd13988  81 YTVLEEPSNAY-GLPEseFLIVLRDVVAGMNHLRENGIVHRDIKPGNIMrvIGEDGQSvyKLTDFGAARELEDDEqFVSL 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKfpiKWTAPEaaLYGR----------FTIKSDVWSFGILQTELVTkGRVPY----PGMVNREVLEQV 483
Cdd:cd13988 160 YGTE---EYLHPD--MYERavlrkdhqkkYGATVDLWSIGVTFYHAAT-GSLPFrpfeGPRRNKEVMYKI 223
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
280-520 1.24e-15

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 77.76  E-value: 1.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG-TWNGTTKVAIKTL----KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFmSKGS 353
Cdd:cd06634  22 EIGHGSFGAVYFArDVRNNEVVAIKKMsysgKQSNEKWQDIIKEVKFLQKLRHPNTIEYRGCyLREHTAWLVMEY-CLGS 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED-NEYTarqGAKF 432
Cdd:cd06634 101 ASDLL-EVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAPaNSFV---GTPY 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pikWTAPEAALY---GRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGyRMPCPQG--CPESLHELMNLCW 507
Cdd:cd06634 177 ---WMAPEVILAmdeGQYDGKVDVWSLGITCIELAER-KPPLFNMNAMSALYHIAQN-ESPALQSghWSEYFRNFVDSCL 251
                       250
                ....*....|...
gi 6678617  508 KKDPDERPTFEYI 520
Cdd:cd06634 252 QKIPQDRPTSDVL 264
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
271-514 1.26e-15

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 77.46  E-value: 1.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTE 347
Cdd:cd06655  17 PKKKYTRYEKIGQGASGTVFTAIDVATgQEVAIKQINLQKQpKKELIINEILVMKELKNPNIVNfLDSFLVGDELFVVME 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYT 425
Cdd:cd06655  97 YLAGGSLTDVVTE---TCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQItpEQSKRS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmVNREVLeqveRGYRMPCPQGCPE-------- 497
Cdd:cd06655 174 TMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPY---LNENPL----RALYLIATNGTPElqnpekls 242
                       250
                ....*....|....*...
gi 6678617  498 -SLHELMNLCWKKDPDER 514
Cdd:cd06655 243 pIFRDFLNRCLEMDVEKR 260
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
272-518 1.41e-15

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 76.99  E-value: 1.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE--AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTE 347
Cdd:cd14167   2 RDIYDFREVLGTGAFSEVVLAEEKRTQKlVAIKCIAKKALEGKetSIENEIAVLHKIKHPNIVALDDIYeSGGHLYLIMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLD------FLKEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANIL---VGENLICKIADFGLARl 418
Cdd:cd14167  82 LVSGGELFDrivekgFYTERDASKL--------IFQILDAVKYLHDMGIVHRDLKPENLLyysLDEDSKIMISDFGLSK- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  419 IEDNEYTARQGAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV---ERGYRMPCPQGC 495
Cdd:cd14167 153 IEGSGSVMSTACGTP-GYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQIlkaEYEFDSPYWDDI 230
                       250       260
                ....*....|....*....|...
gi 6678617  496 PESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14167 231 SDSAKDFIQHLMEKDPEKRFTCE 253
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
280-496 1.63e-15

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 76.97  E-value: 1.63e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKgSLL 355
Cdd:cd07871  12 KLGEGTYATVFKGRSKLTENlVALKEirLEHEEGAPCTAIREVSLLKNLKHANIVTLHDIIhTERCLTLVFEYLDS-DLK 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARliEDNEYTARQGAKFPIK 435
Cdd:cd07871  91 QYL-DNCGNLMSMHNVKIFMFQLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLAR--AKSVPTKTYSNEVVTL 167
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  436 WTAPEAALYG--RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCP 496
Cdd:cd07871 168 WYRPPDVLLGstEYSTPIDMWGVGCILYEMAT-GRPMFPGSTVKEELHLIFRLLGTPTEETWP 229
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
281-514 1.64e-15

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 76.99  E-value: 1.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTL-------KPGTMMPeafLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSK 351
Cdd:cd05630   8 LGKGGFGEVCACQVRATGKMyACKKLekkrikkRKGEAMA---LNEKQILEKVNSRFVVSLaYAYETKDALCLVLTLMNG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSL-LDFLKEGDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQG 429
Cdd:cd05630  85 GDLkFHIYHMGQAGFPE-ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAvHVPEGQTIKGRVG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPY---PGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 506
Cdd:cd05630 164 T---VGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFqqrKKKIKREEVERLVKEVPEEYSEKFSPQARSLCSML 239

                ....*...
gi 6678617  507 WKKDPDER 514
Cdd:cd05630 240 LCKDPAER 247
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
281-525 1.78e-15

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 76.59  E-value: 1.78e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGttKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14153   8 IGKGRFGQVYHGRWHG--EVAIRLIdieRDNEEQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVgENLICKIADFGLARLIEDNEYTARQGA-KFPIKW 436
Cdd:cd14153  86 VVRDAKVVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFY-DNGKVVITDFGLFTISGVLQAGRREDKlRIQSGW 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  437 T---APE---------AALYGRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGYRMPCPQ-GCPESLHELM 503
Cdd:cd14153 165 LchlAPEiirqlspetEEDKLPFSKHSDVFAFGTIWYELHAR-EWPFKTQPAEAIIWQVGSGMKPNLSQiGMGKEISDIL 243
                       250       260
                ....*....|....*....|..
gi 6678617  504 NLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14153 244 LFCWAYEQEERPTFSKLMEMLE 265
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
277-483 2.18e-15

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 76.20  E-value: 2.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGTTKV-AIKTLKP-GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGS 353
Cdd:cd14191   6 IEERLGSGKFGQVFRLVEKKTKKVwAGKFFKAySAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKAnIVMVLEMVSGGE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL----VGENLicKIADFGLARLIEdNEYTARQG 429
Cdd:cd14191  86 LFERIIDEDFE-LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMcvnkTGTKI--KLIDFGLARRLE-NAGSLKVL 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  430 AKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV 483
Cdd:cd14191 162 FGTP-EFVAPEVINYEPIGYATDMWSIGVICYILVS-GLSPFMGDNDNETLANV 213
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
281-528 2.20e-15

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 76.12  E-value: 2.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTL------KPgtMMPEAFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKG 352
Cdd:cd14189   9 LGKGGFARCYEMTDLATNKTyAVKVIphsrvaKP--HQREKIVNEIELHRDLHHKHVVKFsHHFEDAENIYIFLELCSRK 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF 432
Cdd:cd14189  87 SLAHIWKAR--HTLLEPEVRYYLKQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARLEPPEQRKKTICGT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREV---LEQVErgYRMPCPQGCPEslHELMNLCWKK 509
Cdd:cd14189 165 P-NYLAPEVLLRQGHGPESDVWSLGCVMYTLLC-GNPPFETLDLKETyrcIKQVK--YTLPASLSLPA--RHLLAGILKR 238
                       250
                ....*....|....*....
gi 6678617  510 DPDERPTFEYIqsFLEDYF 528
Cdd:cd14189 239 NPGDRLTLDQI--LEHEFF 255
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
273-514 2.54e-15

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 77.27  E-value: 2.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKL-----RHDKLVPLYAVV-SEEPIYIV 345
Cdd:cd05619   5 EDFVLHKMLGKGSFGKVFLAELKGTNQfFAIKALKKDVVLMDDDVECTMVEKRVlslawEHPFLTHLFCTFqTKENLFFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLdFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR--LIEDNE 423
Cdd:cd05619  85 MEYLNGGDLM-FHIQSCHKF-DLPRATFYAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKenMLGDAK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVergyRM--PC-PQGCPESLH 500
Cdd:cd05619 163 TSTFCGTP---DYIAPEILLGQKYNTSVDWWSFGVLLYEMLI-GQSPFHGQDEEELFQSI----RMdnPFyPRWLEKEAK 234
                       250
                ....*....|....
gi 6678617  501 ELMNLCWKKDPDER 514
Cdd:cd05619 235 DILVKLFVREPERR 248
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
280-486 2.87e-15

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 76.05  E-value: 2.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVsEEP--IYIVTEFMSKGS 353
Cdd:cd14097   8 KLGQGSFGVVIEATHKETqTKWAIKKInreKAGSSAVKLLEREVDILKHVNHAHIIHLEEVF-ETPkrMYLVMELCEDGE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFL------KEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILV-------GENLICKIADFGLARL-- 418
Cdd:cd14097  87 LKELLlrkgffSENETRHI--------IQSLASAVAYLHKNDIVHRDLKLENILVkssiidnNDKLNIKVTDFGLSVQky 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  419 -IEDNEYTARQGAkfPIkWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYPGMVNREVLEQVERG 486
Cdd:cd14097 159 gLGEDMLQETCGT--PI-YMAPEVISAHGYSQQCDIWSIGVIMYMLL-CGEPPFVAKSEEKLFEEIRKG 223
PK_IRAK3 cd14160
Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain ...
281-525 3.34e-15

Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK3 (or IRAK-M) is the only IRAK that does not show kinase activity. It is found only in monocytes and macrophages in humans, and functions as a negative regulator of TLR signaling including TLR-2 induced p38 activation. It also negatively regulates the alternative NFkB pathway in a TLR-2 specific manner. IRAK3 is downregulated in the monocytes of obese people, and is associated with high SOD2, a marker of mitochondrial oxidative stress. It is an important inhibitor of inflammation in association with obesity and metabolic syndrome. The IRAK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271062 [Multi-domain]  Cd Length: 276  Bit Score: 76.08  E-value: 3.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWnGTTKVAIKTLKPGTMMP-----EAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSL 354
Cdd:cd14160   1 IGEGEIFEVYRVRI-GNRSYAVKLFKQEKKMQwkkhwKRFLSELEVLLLFQHPNILELAAYFTEtEKFCLVYPYMQNGTL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFL-KEGDGKYLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANILVGENLICKIADFGLARL---IEDNEYT-A 426
Cdd:cd14160  80 FDRLqCHGVTKPLSWHERINILIGIAKAIHYLHNSQpctVICGNISSANILLDDQMQPKLTDFALAHFrphLEDQSCTiN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILQTELVTKGRVPYPGMVN---REVLEQV--ERGYRM----------P 490
Cdd:cd14160 160 MTTALHKHLWYMPEEYIRqGKLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHlqlRDLLHELmeKRGLDSclsfldlkfpP 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 6678617  491 CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14160 240 CPRNFSAKLFRLAGRCTATKAKLRPDMDEVLQRLE 274
SH2_Vav_family cd09940
Src homology 2 (SH2) domain found in the Vav family; Vav proteins are involved in several ...
155-241 3.81e-15

Src homology 2 (SH2) domain found in the Vav family; Vav proteins are involved in several processes that require cytoskeletal reorganization, such as the formation of the immunological synapse (IS), phagocytosis, platelet aggregation, spreading, and transformation. Vavs function as guanine nucleotide exchange factors (GEFs) for the Rho/Rac family of GTPases. Vav family members have several conserved motifs/domains including: a leucine-rich region, a leucine-zipper, a calponin homology (CH) domain, an acidic domain, a Dbl-homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich domain, 2 SH3 domains, a proline-rich region, and a SH2 domain. Vavs are the only known Rho GEFs that have both the DH/PH motifs and SH2/SH3 domains in the same protein. The leucine-rich helix-loop-helix (HLH) domain is thought to be involved in protein heterodimerization with other HLH proteins and it may function as a negative regulator by forming inactive heterodimers. The CH domain is usually involved in the association with filamentous actin, but in Vav it controls NFAT stimulation, Ca2+ mobilization, and its transforming activity. Acidic domains are involved in protein-protein interactions and contain regulatory tyrosines. The DH domain is a GDP-GTP exchange factor on Rho/Rac GTPases. The PH domain in involved in interactions with GTP-binding proteins, lipids and/or phosphorylated serine/threonine residues. The SH3 domain is involved in localization of proteins to specific sites within the cell interacting with protein with proline-rich sequences. The SH2 domain mediates a high affinity interaction with tyrosine phosphorylated proteins. There are three Vav mammalian family members: Vav1 which is expressed in the hematopoietic system, Vav2 and Vav3 are more ubiquitously expressed. The members here include insect and amphibian Vavs. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198193  Cd Length: 102  Bit Score: 71.17  E-value: 3.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRdwdevRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKL 234
Cdd:cd09940   6 LWFVGEMERDTAENRLENRPD--GTYLVRVRPQGETQYALSIK-----YNGDVKHMKIEQRSDGLYYLSESRHFKSLVEL 78

                ....*..
gi 6678617  235 VKHYTEH 241
Cdd:cd09940  79 VNYYERN 85
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
271-524 4.39e-15

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 75.45  E-value: 4.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTKVA---IKTLKPGTMMpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVT 346
Cdd:cd06646   7 PQHDYELIQRVGSGTYGDVYKARNLHTGELAavkIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFgSYLSREKLWICM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDfLKEGDGKYLKLpQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06646  86 EYCGGGSLQD-IYHVTGPLSEL-QIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIkWTAPEAALY---GRFTIKSDVWSFGILQTELVTKgrvpYPGMVN----REVLEQVERGYRMPCPQ---GCP 496
Cdd:cd06646 164 KSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIELAEL----QPPMFDlhpmRALFLMSKSNFQPPKLKdktKWS 238
                       250       260
                ....*....|....*....|....*...
gi 6678617  497 ESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd06646 239 STFHNFVKISLTKNPKKRPTAERLLTHL 266
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
281-483 4.42e-15

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 76.19  E-value: 4.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQEAQIMKKL-----RHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd05616   8 LGKGSFGKVMLAERKGTDELyAVKILKKDVVIQDDDVECTMVEKRVlalsgKPPFLTQLHSCFqTMDRLYFVMEYVNGGD 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGdGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFP 433
Cdd:cd05616  88 LMYHIQQV-GRF-KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 iKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV 483
Cdd:cd05616 166 -DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 213
SH2_Tec_family cd09934
Src homology 2 (SH2) domain found in Tec-like proteins; The Tec protein tyrosine kinase is the ...
149-254 4.71e-15

Src homology 2 (SH2) domain found in Tec-like proteins; The Tec protein tyrosine kinase is the founding member of a family that includes Btk, Itk, Bmx, and Txk. The members have a PH domain, a zinc-binding motif, a SH3 domain, a SH2 domain, and a protein kinase catalytic domain. Btk is involved in B-cell receptor signaling with mutations in Btk responsible for X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Itk is involved in T-cell receptor signaling. Tec is expressed in both T and B cells, and is thought to function in activated and effector T lymphocytes to induce the expression of genes regulated by NFAT transcription factors. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198188  Cd Length: 104  Bit Score: 70.89  E-value: 4.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  149 DSIQAEEWYFGKMGRKDAERLLLNPGNQrGIFLVRESeTTKGAYSLSIrdWDEVRGD-NVKHYKIRKLDNGGYYITTRAQ 227
Cdd:cd09934   1 LNLEKYEWYVGDMSRQRAESLLKQEDKE-GCFVVRNS-STKGLYTVSL--FTKVPGSpHVKHYHIKQNARSEFYLAEKHC 76
                        90       100
                ....*....|....*....|....*...
gi 6678617  228 FDTLQKLVKHYTEHADGLCHKL-TTVCP 254
Cdd:cd09934  77 FETIPELINYHQHNSGGLATRLkYPVCD 104
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
281-483 4.96e-15

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 76.57  E-value: 4.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQEAQIMKKL--RHDK---LVPLYAVVSE-EPIYIVTEFMSKGS 353
Cdd:cd05615  18 LGKGSFGKVMLAERKGSDELyAIKILKKDVVIQDDDVECTMVEKRVlaLQDKppfLTQLHSCFQTvDRLYFVMEYVNGGD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGdGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFP 433
Cdd:cd05615  98 LMYHIQQV-GKF-KEPQAVFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMVEGVTTRTFCGTP 175
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 iKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV 483
Cdd:cd05615 176 -DYIAPEIIAYQPYGRSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSI 223
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
281-516 5.31e-15

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 75.49  E-value: 5.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-----VAIKTLKPGTMmpEAFLQEAQI--MKKLRHDKLVPLYAvvSEEPI-------YIVT 346
Cdd:cd14055   3 VGKGRFAEVWKAKLKQNASgqyetVAVKIFPYEEY--ASWKNEKDIftDASLKHENILQFLT--AEERGvgldrqyWLIT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKegdGKYLKLPQLVDMAAQIADGMAY---------IERMNYIHRDLRAANILVGENLICKIADFGLA- 416
Cdd:cd14055  79 AYHENGSLQDYLT---RHILSWEDLCKMAGSLARGLAHlhsdrtpcgRPKIPIAHRDLKSSNILVKNDGTCVLADFGLAl 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLieDNEYT----ARQGAKFPIKWTAPEaALYGRFT---IKS----DVWSFGILQTELVTK----GRV-----PYPGMVN 476
Cdd:cd14055 156 RL--DPSLSvdelANSGQVGTARYMAPE-ALESRVNledLESfkqiDVYSMALVLWEMASRceasGEVkpyelPFGSKVR 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617  477 -REVLEQV------ERGyRMPCP------QGCpESLHELMNLCWKKDPDERPT 516
Cdd:cd14055 233 eRPCVESMkdlvlrDRG-RPEIPdswlthQGM-CVLCDTITECWDHDPEARLT 283
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
316-520 5.85e-15

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 75.94  E-value: 5.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKegdgKYLKLPQ--LVDMAAQIADGMAYI-ERMNYI 391
Cdd:cd06615  47 IRELKVLHECNSPYIVGFYgAFYSDGEISICMEHMDGGSLDQVLK----KAGRIPEniLGKISIAVLRGLTYLrEKHKIM 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd06615 123 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYTVQSDIWSLGLSLVEMAI-GRYPI 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  472 PG--------MVNREVLEQVERGYRMPCPQGCPES-----LHELM------------------------NLCWKKDPDER 514
Cdd:cd06615 199 PPpdakeleaMFGRPVSEGEAKESHRPVSGHPPDSprpmaIFELLdyivnepppklpsgafsdefqdfvDKCLKKNPKER 278

                ....*.
gi 6678617  515 PTFEYI 520
Cdd:cd06615 279 ADLKEL 284
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
271-514 6.11e-15

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 75.53  E-value: 6.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTE 347
Cdd:cd06656  17 PKKKYTRFEKIGQGASGTVYTAIDIATgQEVAIKQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVME 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYT 425
Cdd:cd06656  97 YLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmVNREVLeqveRGYRMPCPQGCPE-------- 497
Cdd:cd06656 174 TMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMV-EGEPPY---LNENPL----RALYLIATNGTPElqnperls 242
                       250
                ....*....|....*...
gi 6678617  498 -SLHELMNLCWKKDPDER 514
Cdd:cd06656 243 aVFRDFLNRCLEMDVDRR 260
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
265-463 6.52e-15

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 75.06  E-value: 6.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  265 KDAWEIPREslrlevkLGQGCFGEVWMGTwNGTTKV--AIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLY-AVVSEE 340
Cdd:cd06643   4 EDFWEIVGE-------LGDGAFGKVYKAQ-NKETGIlaAAKVIDTKSEEElEDYMVEIDILASCDHPNIVKLLdAFYYEN 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKGSLLDFLKEGDgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLArliE 420
Cdd:cd06643  76 NLWILIEFCAGGAVDAVMLELE-RPLTEPQIRVVCKQTLEALVYLHENKIIHRDLKAGNILFTLDGDIKLADFGVS---A 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  421 DNEYTARQGAKF---PIkWTAPEAALYGR-----FTIKSDVWSFGILQTEL 463
Cdd:cd06643 152 KNTRTLQRRDSFigtPY-WMAPEVVMCETskdrpYDYKADVWSLGVTLIEM 201
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
261-493 7.99e-15

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 75.71  E-value: 7.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  261 QGLAKDAWEIPRESLRLEvKLGQGCFGEVWMGTWNGT-TKVAIKTL-KPgtMMPEAF----LQEAQIMKKLRHDKLVPLY 334
Cdd:cd07879   4 EEVNKTVWELPERYTSLK-QVGSGAYGSVCSAIDKRTgEKVAIKKLsRP--FQSEIFakraYRELTLLKHMQHENVIGLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  335 AVVSEEPI-------YIVTEFMSKGslldfLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLI 407
Cdd:cd07879  81 DVFTSAVSgdefqdfYLVMPYMQTD-----LQKIMGHPLSEDKVQYLVYQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  408 CKIADFGLARLiEDNEYTARQGAKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG 486
Cdd:cd07879 156 LKILDFGLARH-ADAEMTGYVVTRW---YRAPEVILnWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKV 230

                ....*..
gi 6678617  487 YRMPCPQ 493
Cdd:cd07879 231 TGVPGPE 237
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
274-472 8.13e-15

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 74.69  E-value: 8.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  274 SLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTL-KPGTMMPEA-------FLQEAQIMKKL-RHDKLVPLYAVV-SEEPI 342
Cdd:cd13993   1 RYQLISPIGEGAYGVVYLAVDLRTgRKYAIKCLyKSGPNSKDGndfqklpQLREIDLHRRVsRHPNIITLHDVFeTEVAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEgDGKYLKLPQLV-DMAAQIADGMAYIERMNYIHRDLRAANILVGENLI-CKIADFGLArLIE 420
Cdd:cd13993  81 YIVLEYCPNGDLFEAITE-NRIYVGKTELIkNVFLQLIDAVKHCHSLGIYHRDIKPENILLSQDEGtVKLCDFGLA-TTE 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  421 DNEYTARQGAKF---P--IKWTAPEAALYGrfTIKSDVWSFGILQTELVTkGRVPYP 472
Cdd:cd13993 159 KISMDFGVGSEFymaPecFDEVGRSLKGYP--CAAGDIWSLGIILLNLTF-GRNPWK 212
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
281-530 8.48e-15

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 74.58  E-value: 8.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKVAIKTLKPGTMM-----PEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd14187  15 LGKGGFAKCYEITDADTKEVFAGKIVPKSLLlkphqKEKMSMEIAIHRSLAHQHVVGFHGFFEDNDfVYVVLELCRRRSL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEGdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPi 434
Cdd:cd14187  95 LELHKRR--KALTEPEARYYLRQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGERKKTLCGTP- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWTAPEAALYGRFTIKSDVWSFG-ILQTELVtkGRVPYPGMVNREVLEQVERGyRMPCPQGCPESLHELMNLCWKKDPDE 513
Cdd:cd14187 172 NYIAPEVLSKKGHSFEVDIWSIGcIMYTLLV--GKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTA 248
                       250
                ....*....|....*...
gi 6678617  514 RPTfeyIQSFLED-YFTA 530
Cdd:cd14187 249 RPT---INELLNDeFFTS 263
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
281-468 8.99e-15

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 74.79  E-value: 8.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEV--WMGTWNGTtKVAIKT----LKPGTMMPEAFLQEAQIMKKLRHDKLV-------PLYAVVSEEPIYIVTE 347
Cdd:cd13989   1 LGSGGFGYVtlWKHQDTGE-YVAIKKcrqeLSPSDKNRERWCLEVQIMKKLNHPNVVsardvppELEKLSPNDLPLLAME 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSL---LDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL---VGENLICKIADFGLARLIED 421
Cdd:cd13989  80 YCSGGDLrkvLNQPENCCG--LKESEVRTLLSDISSAISYLHENRIIHRDLKPENIVlqqGGGRVIYKLIDLGYAKELDQ 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6678617  422 NEY-TARQGAkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR 468
Cdd:cd13989 158 GSLcTSFVGT---LQYLAPELFESKKYTCTVDYWSFGTLAFECITGYR 202
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
280-518 1.05e-14

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 75.09  E-value: 1.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTL----KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAV-VSEEPIYIVTEFmSKGS 353
Cdd:cd06635  32 EIGHGSFGAVYFARDVRTSEVvAIKKMsysgKQSNEKWQDIIKEVKFLQRIKHPNSIEYKGCyLREHTAWLVMEY-CLGS 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLkEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED-NEYTarqGAKF 432
Cdd:cd06635 111 ASDLL-EVHKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPaNSFV---GTPY 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 pikWTAPEAALY---GRFTIKSDVWSFGILQTELVTKgRVPYPGMVNREVLEQVERGyRMPCPQGCPES--LHELMNLCW 507
Cdd:cd06635 187 ---WMAPEVILAmdeGQYDGKVDVWSLGITCIELAER-KPPLFNMNAMSALYHIAQN-ESPTLQSNEWSdyFRNFVDSCL 261
                       250
                ....*....|.
gi 6678617  508 KKDPDERPTFE 518
Cdd:cd06635 262 QKIPQDRPTSE 272
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
271-518 1.10e-14

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 74.31  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTKVA-IKTLK--PGTMMpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVT 346
Cdd:cd06645   9 PQEDFELIQRIGSGTYGDVYKARNVNTGELAaIKVIKlePGEDF-AVVQQEIIMMKDCKHSNIVAYFgSYLRRDKLWICM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTA 426
Cdd:cd06645  88 EFCGGGSLQDIYHVTGP--LSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKFPIkWTAPEAALYGR---FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG---CPESLH 500
Cdd:cd06645 166 KSFIGTPY-WMAPEVAAVERkggYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDkmkWSNSFH 244
                       250
                ....*....|....*...
gi 6678617  501 ELMNLCWKKDPDERPTFE 518
Cdd:cd06645 245 HFVKMALTKNPKKRPTAE 262
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
283-521 1.13e-14

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 74.17  E-value: 1.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  283 QGCFGEVWMGTWNGTTKV-AIKTLKP----GTMMPEAFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKG---S 353
Cdd:cd05579   3 RGAYGRVYLAKKKSTGDLyAIKVIKKrdmiRKNQVDSVLAERNILSQAQNPFVVKLyYSFQGKKNLYLVMEYLPGGdlyS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDflkegdgKYLKLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARL-IEDNEYTARQ 428
Cdd:cd05579  83 LLE-------NVGALDE--DVAriyiAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGLSKVgLVRRQIKLSI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPIKWT-------------APEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVeRGYRMPCPQgC 495
Cdd:cd05579 154 QKKSNGAPEkedrrivgtpdylAPEILLGQGHGKTVDWWSLGVILYEFLV-GIPPFHAETPEEIFQNI-LNGKIEWPE-D 230
                       250       260
                ....*....|....*....|....*....
gi 6678617  496 PESLHELMNLCWK---KDPDERPTFEYIQ 521
Cdd:cd05579 231 PEVSDEAKDLISKlltPDPEKRLGAKGIE 259
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
280-473 1.38e-14

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 74.47  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   280 KLGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSkgsl 354
Cdd:PLN00009   9 KIGEGTYGVVYKARDRVTNEtIALKKIRleqEDEGVPSTAIREISLLKEMQHGNIVRLQDVVhSEKRLYLVFEYLD---- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   355 LDFLKEGDG--KYLKLPQLVDMAA-QIADGMAYIERMNYIHRDLRAANILVGE-NLICKIADFGLARL--IEDNEYTARQ 428
Cdd:PLN00009  85 LDLKKHMDSspDFAKNPRLIKTYLyQILRGIAYCHSHRVLHRDLKPQNLLIDRrTNALKLADFGLARAfgIPVRTFTHEV 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 6678617   429 gakFPIKWTAPEAALYGR-FTIKSDVWSFGILQTELVTKgRVPYPG 473
Cdd:PLN00009 165 ---VTLWYRAPEILLGSRhYSTPVDIWSVGCIFAEMVNQ-KPLFPG 206
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
281-483 1.40e-14

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 73.79  E-value: 1.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMM-PEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14193  12 LGGGRFGQVHKCEEKSSgLKLAAKIIKARSQKeKEEVKNEIEVMNQLNHANLIQLYdAFESRNDIVLVMEYVDGGELFDR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYLKLPQLVDMAaQIADGMAYIERMNYIHRDLRAANILV--GENLICKIADFGLARliednEYTARQGAKFPI- 434
Cdd:cd14193  92 IIDENYNLTELDTILFIK-QICEGIQYMHQMYILHLDLKPENILCvsREANQVKIIDFGLAR-----RYKPREKLRVNFg 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617  435 --KWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV 483
Cdd:cd14193 166 tpEFLAPEVVNYEFVSFPTDMWSLGVIAYMLLS-GLSPFLGEDDNETLNNI 215
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
280-496 1.43e-14

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 74.34  E-value: 1.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIK--TLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGsll 355
Cdd:cd07844   7 KLGEGSYATVYKGRSKLTGQlVALKeiRLEHEEGAPFTAIREASLLKDLKHANIVTLHDIIhTKKTLTLVFEYLDTD--- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 dfLKegdgKYL-KLPQLVDMAA------QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARliedneytarq 428
Cdd:cd07844  84 --LK----QYMdDCGGGLSMHNvrlflfQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLAR----------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  429 gAK-FPIK---------WTAPEAALYGR--FTIKSDVWSFGILQTELVTkGRVPYPGMvnREVLEQVERGYRM---PCPQ 493
Cdd:cd07844 147 -AKsVPSKtysnevvtlWYRPPDVLLGSteYSTSLDMWGVGCIFYEMAT-GRPLFPGS--TDVEDQLHKIFRVlgtPTEE 222

                ...
gi 6678617  494 GCP 496
Cdd:cd07844 223 TWP 225
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
306-521 1.51e-14

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 74.22  E-value: 1.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  306 KPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFMSKGSLLD------FLKEGDGKYLKlpqlvdma 375
Cdd:cd14200  60 QAKPLAPlERVYQEIAILKKLDHVNIVKLIEVLddpAEDNLYMVFDLLRKGPVMEvpsdkpFSEDQARLYFR-------- 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  376 aQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYGR--FTIKS-D 452
Cdd:cd14200 132 -DIVLGIEYLHYQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDALLSSTAGTP-AFMAPETLSDSGqsFSGKAlD 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678617  453 VWSFGILQTELVTkGRVPYP-----GMVNREVLEQVErgyrMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 521
Cdd:cd14200 210 VWAMGVTLYCFVY-GKCPFIdefilALHNKIKNKPVE----FPEEPEISEELKDLILKMLDKNPETRITVPEIK 278
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
313-483 1.72e-14

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 73.88  E-value: 1.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  313 EAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYI 391
Cdd:cd14195  53 EEIEREVNILREIQHPNIITLHDIFENKTdVVLILELVSGGELFDFLAEKES--LTEEEATQFLKQILDGVHYLHSKRIA 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 HRDLRAANILVGE----NLICKIADFGLARLIE-DNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILqTELVTK 466
Cdd:cd14195 131 HFDLKPENIMLLDknvpNPRIKLIDFGIAHKIEaGNEFKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGVI-TYILLS 206
                       170
                ....*....|....*..
gi 6678617  467 GRVPYPGMVNREVLEQV 483
Cdd:cd14195 207 GASPFLGETKQETLTNI 223
SH2_Cterm_shark_like cd10348
C-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) ...
155-245 1.85e-14

C-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins; These non-receptor protein-tyrosine kinases contain two SH2 domains, five ankyrin (ANK)-like repeats, and a potential tyrosine phosphorylation site in its carboxyl-terminal tail which resembles the phosphorylation site in members of the src family. Like, mammalian non-receptor protein-tyrosine kinases, ZAP-70 and syk proteins, they do not have SH3 domains. However, the presence of ANK makes these unique among protein-tyrosine kinases. Both tyrosine kinases and ANK repeats have been shown to transduce developmental signals, and SH2 domains are known to participate intimately in tyrosine kinase signaling. These tyrosine kinases are believed to be involved in epithelial cell polarity. The members of this family include the shark (SH2 domains, ANK, and kinase domain) gene in Drosophila and yellow fever mosquitos, as well as the hydra protein HTK16. Drosophila Shark is proposed to transduce intracellularly the Crumbs, a protein necessary for proper organization of ectodermal epithelia, intercellular signal. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198211  Cd Length: 86  Bit Score: 68.60  E-value: 1.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIrdwdeVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKL 234
Cdd:cd10348   1 QWLHGALDRNEAVEILKQKADADGSFLVRYSRRRPGGYVLTL-----VYENHVYHFEIQNRDDKWFYIDDGPYFESLEHL 75
                        90
                ....*....|.
gi 6678617  235 VKHYTEHADGL 245
Cdd:cd10348  76 IEHYTQFADGL 86
SH2_C-SH2_Syk_like cd10401
C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; ZAP-70 ...
156-254 1.88e-14

C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins; ZAP-70 and Syk comprise a family of hematopoietic cell specific protein tyrosine kinases (PTKs) that are required for antigen and antibody receptor function. ZAP-70 is expressed in T and natural killer (NK) cells and Syk is expressed in B cells, mast cells, polymorphonuclear leukocytes, platelets, macrophages, and immature T cells. They are required for the proper development of T and B cells, immune receptors, and activating NK cells. They consist of two N-terminal Src homology 2 (SH2) domains and a C-terminal kinase domain separated from the SH2 domains by a linker or hinge region. Phosphorylation of both tyrosine residues within the Immunoreceptor Tyrosine-based Activation Motifs (ITAM; consensus sequence Yxx[LI]x(7,8)Yxx[LI]) by the Src-family PTKs is required for efficient interaction of ZAP-70 and Syk with the receptor subunits and for receptor function. ZAP-70 forms two phosphotyrosine binding pockets, one of which is shared by both SH2 domains. In Syk the two SH2 domains do not form such a phosphotyrosine-binding site. The SH2 domains here are believed to function independently. In addition, the two SH2 domains of Syk display flexibility in their relative orientation, allowing Syk to accommodate a greater variety of spacing sequences between the ITAM phosphotyrosines and singly phosphorylated non-classical ITAM ligands. This model contains the C-terminus SH2 domains of Syk. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198264  Cd Length: 99  Bit Score: 69.15  E-value: 1.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETtKGAYSLSIrdwdeVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd10401   5 WFHGKISREESEQILLIGSKTNGKFLIRERDN-NGSYALCL-----LHDGKVLHYRIDKDKTGKLSIPDGKKFDTLWQLV 78
                        90
                ....*....|....*....
gi 6678617  236 KHYTEHADGLCHKLTTVCP 254
Cdd:cd10401  79 EHYSYKPDGLLRVLTEPCP 97
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
299-518 2.34e-14

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 73.10  E-value: 2.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  299 KVAIKTL-KPGTmmPEAFLQ-----EAQIMKKLRHDKLVPLYAVV--SEEPIYIVTEFMSKGSLLDF------LKEGDGK 364
Cdd:cd14163  27 KVAIKIIdKSGG--PEEFIQrflprELQIVERLDHKNIIHVYEMLesADGKIYLVMELAEDGDVFDCvlhggpLPEHRAK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  365 YLKLpqlvdmaaQIADGMAYIERMNYIHRDLRAANILV-GENLicKIADFGLARLIEDNEYTARQGAKFPIKWTAPEaAL 443
Cdd:cd14163 105 ALFR--------QLVEAIRYCHGCGVAHRDLKCENALLqGFTL--KLTDFGFAKQLPKGGRELSQTFCGSTAYAAPE-VL 173
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  444 YG--RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14163 174 QGvpHDSRKGDIWSMGVVLYVMLC-AQLPFDDTDIPKMLCQQQKGVSLPGHLGVSRTCQDLLKRLLEPDMVLRPSIE 249
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
281-514 2.59e-14

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 73.82  E-value: 2.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKL-----RHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd05620   3 LGKGSFGKVLLAELKGKGEyFAVKALKKDVVLIDDDVECTMVEKRVlalawENPFLTHLYCTFqTKEHLFFVMEFLNGGD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEgDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR--LIEDNEYTARQGAK 431
Cdd:cd05620  83 LMFHIQD-KGRF-DLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKenVFGDNRASTFCGTP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 fpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVergyRMPC---PQGCPESLHELMNLCWK 508
Cdd:cd05620 161 ---DYIAPEILQGLKYTFSVDWWSFGVLLYEMLI-GQSPFHGDDEDELFESI----RVDTphyPRWITKESKDILEKLFE 232

                ....*.
gi 6678617  509 KDPDER 514
Cdd:cd05620 233 RDPTRR 238
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
281-515 2.59e-14

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 73.07  E-value: 2.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTT-----KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSL 354
Cdd:cd14116  13 LGKGKFGNVYLAREKQSKfilalKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATrVYLILEYAPLGTV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKegdgkylKLPQLVDMAA-----QIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQG 429
Cdd:cd14116  93 YRELQ-------KLSKFDEQRTatyitELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  430 AkfpIKWTAPEaALYGRF-TIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERgYRMPCPQGCPESLHELMNLCWK 508
Cdd:cd14116 166 T---LDYLPPE-MIEGRMhDEKVDLWSLGVLCYEFLV-GKPPFEANTYQETYKRISR-VEFTFPDFVTEGARDLISRLLK 239

                ....*..
gi 6678617  509 KDPDERP 515
Cdd:cd14116 240 HNPSQRP 246
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
317-526 2.92e-14

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 73.51  E-value: 2.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVVSE--EPIYIVTEFMSkGSLLDFLKEGD-----GKYLKLPQLVDMAA-----QIADGMAY 384
Cdd:cd14011  51 RGVKQLTRLRHPRILTVQHPLEEsrESLAFATEPVF-ASLANVLGERDnmpspPPELQDYKLYDVEIkygllQISEALSF 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  385 I-ERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKF----------PIKWTAPEAALYGRFTIKSDV 453
Cdd:cd14011 130 LhNDVKLVHGNICPESVVINSNGEWKLAGFDFCISSEQATDQFPYFREYdpnlpplaqpNLNYLAPEYILSKTCDPASDM 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  454 WSFGILQTELVTKGRVPY---PGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYI--QSFLED 526
Cdd:cd14011 210 FSLGVLIYAIYNKGKPLFdcvNNLLSYKKNSNQLRQLSLSLLEKVPEELRDHVKTLLNVTPEVRPDAEQLskIPFFDD 287
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
280-485 3.00e-14

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 73.00  E-value: 3.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV--AIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLD 356
Cdd:cd14114   9 ELGTGAFGVVHRCTERATGNNfaAKFIMTPHESDKETVRKEIQIMNQLHHPKLINLHdAFEDDNEMVLILEFLSGGELFE 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV----GENLicKIADFGLARLIEDNEYTARQGAKf 432
Cdd:cd14114  89 RIAAEHYK-MSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIMCttkrSNEV--KLIDFGLATHLDPKESVKVTTGT- 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617  433 pIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER 485
Cdd:cd14114 165 -AEFAAPEIVEREPVGFYTDMWAVGVLSYVLLS-GLSPFAGENDDETLRNVKS 215
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
281-466 3.17e-14

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 73.19  E-value: 3.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM------GTWNGTTKVAIKTLKPGTMMPEAFLQ-EAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFMS 350
Cdd:cd06651  15 LGQGAFGRVYLcydvdtGRELAAKQVQFDPESPETSKEVSALEcEIQLLKNLQHERIVQYYGCLrdrAEKTLTIFMEYMP 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KGSLLDFLKegdgKYLKLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED--NEYTA 426
Cdd:cd06651  95 GGSVKDQLK----AYGALTESVtrKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTicMSGTG 170
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6678617  427 RQGAKFPIKWTAPEAAL---YGRftiKSDVWSFGILQTELVTK 466
Cdd:cd06651 171 IRSVTGTPYWMSPEVISgegYGR---KADVWSLGCTVVEMLTE 210
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
280-483 3.50e-14

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 73.94  E-value: 3.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT-TKVAIKTLkpgtmmPEAF---------LQEAQIMKKLRHDKLVPlyavvseepiyIVTEFM 349
Cdd:cd07855  12 TIGSGAYGVVCSAIDTKSgQKVAIKKI------PNAFdvvttakrtLRELKILRHFKHDNIIA-----------IRDILR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDF--------LKEGD-------GKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG 414
Cdd:cd07855  75 PKVPYADFkdvyvvldLMESDlhhiihsDQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  415 LARLIEDN---------EYTArqgakfpIKW-TAPEAAL-YGRFTIKSDVWSFGILQTELVtkGRVP-YPGmvnREVLEQ 482
Cdd:cd07855 155 MARGLCTSpeehkyfmtEYVA-------TRWyRAPELMLsLPEYTQAIDMWSVGCIFAEML--GRRQlFPG---KNYVHQ 222

                .
gi 6678617  483 V 483
Cdd:cd07855 223 L 223
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
281-468 3.75e-14

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 73.03  E-value: 3.75e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTT-KVAIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI------VTEFMSK 351
Cdd:cd14039   1 LGTGGFGNVCLYQNQETGeKIAIKScrLELSVKNKDRWCHEIQIMKKLNHPNVVKACDVPEEMNFLVndvpllAMEYCSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFL-KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL---VGENLICKIADFGLARLIEDNEY-TA 426
Cdd:cd14039  81 GDLRKLLnKPENCCGLKESQVLSLLSDIGSGIQYLHENKIIHRDLKPENIVlqeINGKIVHKIIDLGYAKDLDQGSLcTS 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6678617  427 RQGAkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR 468
Cdd:cd14039 161 FVGT---LQYLAPELFENKSYTVTVDYWSFGTMVFECIAGFR 199
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
275-496 4.44e-14

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 73.10  E-value: 4.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEvKLGQGCFGEVWMGTWNGTTK-VAIKT--LKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMS 350
Cdd:cd07872   9 IKLE-KLGEGTYATVFKGRSKLTENlVALKEirLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVhTDKSLTLVFEYLD 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  351 KgSLLDFLKEGdGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARliEDNEYTARQGA 430
Cdd:cd07872  88 K-DLKQYMDDC-GNIMSMHNVKIFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLAR--AKSVPTKTYSN 163
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  431 KFPIKWTAPEAALYG--RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCP 496
Cdd:cd07872 164 EVVTLWYRPPDVLLGssEYSTQIDMWGVGCIFFEMAS-GRPLFPGSTVEDELHLIFRLLGTPTEETWP 230
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
281-483 4.48e-14

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 72.30  E-value: 4.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLK-PGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDF 357
Cdd:cd14192  12 LGGGRFGQVHKCTELSTgLTLAAKIIKvKGAKEREEVKNEINIMNQLNHVNLIQLYdAFESKTNLTLIMEYVDGGELFDR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  358 LKEGDGKYLKLPQLVdMAAQIADGMAYIERMNYIHRDLRAANIL----VGENLicKIADFGLARliednEYTARQGAKFP 433
Cdd:cd14192  92 ITDESYQLTELDAIL-FTRQICEGVHYLHQHYILHLDLKPENILcvnsTGNQI--KIIDFGLAR-----RYKPREKLKVN 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617  434 I---KWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYPGMVNREVLEQV 483
Cdd:cd14192 164 FgtpEFLAPEVVNYDFVSFPTDMWSVGVI-TYMLLSGLSPFLGETDAETMNNI 215
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
276-523 4.54e-14

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 73.36  E-value: 4.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEV--KLGQGCFGEVWMGTwNGTTK--VAIKTLKpgtmmpEAF--LQEAQ-----IM--KKLR-HDKLVPLYAVVSEE- 340
Cdd:cd07852   8 RYEIlkKLGKGAYGIVWKAI-DKKTGevVALKKIF------DAFrnATDAQrtfreIMflQELNdHPNIIKLLNVIRAEn 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 --PIYIVTEFMS--------KGSLLDFLKegdgKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd07852  81 dkDIYLVFEYMEtdlhavirANILEDIHK----QYI--------MYQLLKALKYLHSGGVIHRDLKPSNILLNSDCRVKL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDNEytarQGAKFPI-------KW-TAPEaALYG--RFTIKSDVWSFGILQTELVTkGRVPYPG------- 473
Cdd:cd07852 149 ADFGLARSLSQLE----EDDENPVltdyvatRWyRAPE-ILLGstRYTKGVDMWSVGCILGEMLL-GKPLFPGtstlnql 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  474 --------MVNREVLEQVERGY------RMP----------CPQGCPESLhELMNLCWKKDPDERPTFE------YIQSF 523
Cdd:cd07852 223 ekiievigRPSAEDIESIQSPFaatmleSLPpsrpksldelFPKASPDAL-DLLKKLLVFNPNKRLTAEealrhpYVAQF 301
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
280-520 4.79e-14

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 72.03  E-value: 4.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQ---------EAQIMKKLRHD------KLVPLYAvvSEEPIY 343
Cdd:cd14004   7 EMGEGAYGQVNLAIYKSKGKeVVIKFIFKERILVDTWVRdrklgtvplEIHILDTLNKRshpnivKLLDFFE--DDEFYY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFMSKG-SLLDF------LKEGDGKYLklpqlvdmAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA 416
Cdd:cd14004  85 LVMEKHGSGmDLFDFierkpnMDEKEAKYI--------FRQVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDFGSA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 RLIEDNEYTARQGAkfpIKWTAPEAALYGRFTIKS-DVWSFGILQTELVTKgRVPYpgmvnREVLEQVERGYRMpcPQGC 495
Cdd:cd14004 157 AYIKSGPFDTFVGT---IDYAAPEVLRGNPYGGKEqDIWALGVLLYTLVFK-ENPF-----YNIEEILEADLRI--PYAV 225
                       250       260
                ....*....|....*....|....*
gi 6678617  496 PESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd14004 226 SEDLIDLISRMLNRDVGDRPTIEEL 250
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
280-485 4.80e-14

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 72.80  E-value: 4.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLK----PGTmmPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKgS 353
Cdd:cd07869  12 KLGEGSYATVYKGKSKVNGKlVALKVIRlqeeEGT--PFTAIREASLLKGLKHANIVLLHDIIhTKETLTLVFEYVHT-D 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQgaKFP 433
Cdd:cd07869  89 LCQYMDKHPGG-LHPENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSN--EVV 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  434 IKWTAPEAALYG--RFTIKSDVWSFGILQTELVtKGRVPYPGMvnREVLEQVER 485
Cdd:cd07869 166 TLWYRPPDVLLGstEYSTCLDMWGVGCIFVEMI-QGVAAFPGM--KDIQDQLER 216
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
281-525 5.18e-14

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 72.31  E-value: 5.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGttKVAIKTLK-PGTMMPEAFLQEAQIM--KKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLD 356
Cdd:cd14152   8 IGQGRWGKVHRGRWHG--EVAIRLLEiDGNNQDHLKLFKKEVMnyRQTRHENVVLFMGACMHPPhLAIITSFCKGRTLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICkIADFGLARLIEDNEYTARQGA-KFPIK 435
Cdd:cd14152  86 FVRDPKTS-LDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGLFGISGVVQEGRRENElKLPHD 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  436 WT---APEAALY---GR------FTIKSDVWSFGILQTELVTKGRvPYPGMVNREVLEQVERG---YRMPCPQGCPESLH 500
Cdd:cd14152 164 WLcylAPEIVREmtpGKdedclpFSKAADVYAFGTIWYELQARDW-PLKNQPAEALIWQIGSGegmKQVLTTISLGKEVT 242
                       250       260
                ....*....|....*....|....*
gi 6678617  501 ELMNLCWKKDPDERPTFEYIQSFLE 525
Cdd:cd14152 243 EILSACWAFDLEERPSFTLLMDMLE 267
SH2_Nck_family cd09943
Src homology 2 (SH2) domain found in the Nck family; Nck proteins are adaptors that modulate ...
154-239 5.78e-14

Src homology 2 (SH2) domain found in the Nck family; Nck proteins are adaptors that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates. There are two members known in this family: Nck1 (Nckalpha) and Nck2 (Nckbeta and Growth factor receptor-bound protein 4 (Grb4)). They are characterized by having 3 SH3 domains and a C-terminal SH2 domain. Nck1 and Nck2 have overlapping functions as determined by gene knockouts. Both bind receptor tyrosine kinases and other tyrosine-phosphorylated proteins through their SH2 domains. In addition they also bind distinct targets. Neuronal signaling proteins: EphrinB1, EphrinB2, and Disabled-1 (Dab-1) all bind to Nck-2 exclusively. And in the case of PDGFR, Tyr(P)751 binds to Nck1 while Tyr(P)1009 binds to Nck2. Nck1 and Nck2 have a role in the infection process of enteropathogenic Escherichia coli (EPEC). Their SH3 domains are involved in recruiting and activating the N-WASP/Arp2/3 complex inducing actin polymerization resulting in the production of pedestals, dynamic bacteria-presenting protrusions of the plasma membrane. A similar thing occurs in the vaccinia virus where motile plasma membrane projections are formed beneath the virus. Recently it has been shown that the SH2 domains of both Nck1 and Nck2 bind the G-protein coupled receptor kinase-interacting protein 1 (GIT1) in a phosphorylation-dependent manner. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198196  Cd Length: 93  Bit Score: 67.54  E-value: 5.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  154 EEWYFGKMGRKDAERLLLNPGNQrGIFLVRESETTKGAYSLSIRdwdeVRGDNvKHYKIrKLDNGGYYITTRaQFDTLQK 233
Cdd:cd09943   1 QPWYYGRITRHQAETLLNEHGHE-GDFLIRDSESNPGDYSVSLK----APGRN-KHFKV-QVVDNVYCIGQR-KFHTMDE 72

                ....*.
gi 6678617  234 LVKHYT 239
Cdd:cd09943  73 LVEHYK 78
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
317-483 5.89e-14

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 72.30  E-value: 5.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDL 395
Cdd:cd14196  57 REVSILRQVLHPNIITLHDVYENRTdVVLILELVSGGELFDFLAQKES--LSEEEATSFIKQILDGVNYLHTKKIAHFDL 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  396 RAANILVGENLI----CKIADFGLARLIEDN-EYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVP 470
Cdd:cd14196 135 KPENIMLLDKNIpiphIKLIDFGLAHEIEDGvEFKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGVI-TYILLSGASP 210
                       170
                ....*....|...
gi 6678617  471 YPGMVNREVLEQV 483
Cdd:cd14196 211 FLGDTKQETLANI 223
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
272-485 6.24e-14

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 72.70  E-value: 6.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKTL-------KPGTMMPeafLQEAQIMKKLRHDKLVPL-YAVVSEEPI 342
Cdd:cd05632   1 KNTFRQYRVLGKGGFGEVCACQVRATGKMyACKRLekkrikkRKGESMA---LNEKQILEKVNSQFVVNLaYAYETKDAL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd05632  78 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 157
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  423 EYTarQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYPGMVNREVLEQVER 485
Cdd:cd05632 158 ESI--RGRVGTVGYMAPEVLNNQRYTLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDR 217
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
271-514 6.39e-14

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 72.45  E-value: 6.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTM-MPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPIYIVTE 347
Cdd:cd06654  18 PKKKYTRFEKIGQGASGTVYTAMDVATgQEVAIRQMNLQQQpKKELIINEILVMRENKNPNIVNyLDSYLVGDELWVVME 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI--EDNEYT 425
Cdd:cd06654  98 YLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQItpEQSKRS 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  426 ARQGAKFpikWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYpgmVNREVLeqveRGYRMPCPQGCPE-------- 497
Cdd:cd06654 175 TMVGTPY---WMAPEVVTRKAYGPKVDIWSLGIMAIEMI-EGEPPY---LNENPL----RALYLIATNGTPElqnpekls 243
                       250
                ....*....|....*...
gi 6678617  498 -SLHELMNLCWKKDPDER 514
Cdd:cd06654 244 aIFRDFLNRCLEMDVEKR 261
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
280-483 7.09e-14

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 72.40  E-value: 7.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTwNGTTK--VAIKTLKpgtM------MPEAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEF 348
Cdd:cd07845  14 RIGEGTYGIVYRAR-DTTSGeiVALKKVR---MdnerdgIPISSLREITLLLNLRHPNIVELKEVVvgkHLDSIFLVMEY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 MSK--GSLLDFLKEGdgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE--DNEY 424
Cdd:cd07845  90 CEQdlASLLDNMPTP----FSESQVKCLMLQLLRGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLARTYGlpAKPM 165
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678617  425 TARQgakFPIKWTAPEaALYG--RFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV 483
Cdd:cd07845 166 TPKV---VTLWYRAPE-LLLGctTYTTAIDMWAVGCILAELLA-HKPLLPGKSEIEQLDLI 221
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
281-466 7.56e-14

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 73.24  E-value: 7.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGT--WNGTtKVAIKTlkpgtmMPEAF---------LQEAQIMKKLRHDKLVPLYAVVSE------EPIY 343
Cdd:cd07853   8 IGYGAFGVVWSVTdpRDGK-RVALKK------MPNVFqnlvsckrvFRELKMLCFFKHDNVLSALDILQPphidpfEEIY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 IVTEFM---------SKGSLLDflkegdgKYLKLpqlvdMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG 414
Cdd:cd07853  81 VVTELMqsdlhkiivSPQPLSS-------DHVKV-----FLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFG 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  415 LARLIEDNE---YTARQGAKFpikWTAPEAALYGR-FTIKSDVWSFGILQTELVTK 466
Cdd:cd07853 149 LARVEEPDEskhMTQEVVTQY---YRAPEILMGSRhYTSAVDIWSVGCIFAELLGR 201
SH2_Nterm_shark_like cd10347
N-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) ...
156-238 7.64e-14

N-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins; These non-receptor protein-tyrosine kinases contain two SH2 domains, five ankyrin (ANK)-like repeats, and a potential tyrosine phosphorylation site in the carboxyl-terminal tail which resembles the phosphorylation site in members of the src family. Like, mammalian non-receptor protein-tyrosine kinases, ZAP-70 and syk proteins, they do not have SH3 domains. However, the presence of ANK makes these unique among protein-tyrosine kinases. Both tyrosine kinases and ANK repeats have been shown to transduce developmental signals, and SH2 domains are known to participate intimately in tyrosine kinase signaling. These tyrosine kinases are believed to be involved in epithelial cell polarity. The members of this family include the shark (SH2 domains, ANK, and kinase domain) gene in Drosophila and yellow fever mosquitos, as well as the hydra protein HTK16. Drosophila Shark is proposed to transduce intracellularly the Crumbs, a protein necessary for proper organization of ectodermal epithelia, intercellular signal. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198210  Cd Length: 81  Bit Score: 66.63  E-value: 7.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRgdnvkHYKIRKL-------DNGGYYittraqF 228
Cdd:cd10347   3 WYHGKISREVAEALLLREGGRDGLFLVRESTSAPGDYVLSLLAQGEVL-----HYQIRRHgedaffsDDGPLI------F 71
                        90
                ....*....|
gi 6678617  229 DTLQKLVKHY 238
Cdd:cd10347  72 HGLDTLIEHY 81
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
303-458 7.77e-14

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 71.92  E-value: 7.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  303 KTLKPGTMMP----EAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFMSKGSLLDFLKEgdgKYLKLPQLVDMA 375
Cdd:cd14199  56 RAAPEGCTQPrgpiERVYQEIAILKKLDHPNVVKLVEVLddpSEDHLYMVFELVKQGPVMEVPTL---KPLSEDQARFYF 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  376 AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYGR--FTIKS-D 452
Cdd:cd14199 133 QDLIKGIEYLHYQKIIHRDVKPSNLLVGEDGHIKIADFGVSNEFEGSDALLTNTVGTP-AFMAPETLSETRkiFSGKAlD 211

                ....*.
gi 6678617  453 VWSFGI 458
Cdd:cd14199 212 VWAMGV 217
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
280-522 9.01e-14

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 71.50  E-value: 9.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGT-WNGTTKVAIK-----------TLKPGTMMPE--AFLQEAQimkKLRHDKLVPL---------YAV 336
Cdd:cd14005   7 LLGKGGFGTVYSGVrIRDGLPVAVKfvpksrvtewaMINGPVPVPLeiALLLKAS---KPGVPGVIRLldwyerpdgFLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  337 VSEEPIYIVTefmskgsLLDFLKEgdgkYLKLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLIC-KIA 411
Cdd:cd14005  84 IMERPEPCQD-------LFDFITE----RGALSE--NLAriifRQVVEAVRHCHQRGVLHRDIKDENLLINLRTGEvKLI 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  412 DFGLARLIEDNEYTARQGAKFpikWTAPEAALYGRFTIKS-DVWSFGILQTELVTkGRVPYpgmvnREVLEQVERGYRMp 490
Cdd:cd14005 151 DFGCGALLKDSVYTDFDGTRV---YSPPEWIRHGRYHGRPaTVWSLGILLYDMLC-GDIPF-----ENDEQILRGNVLF- 220
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  491 cPQGCPESLHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14005 221 -RPRLSKECCDLISRCLQFDPSKRPSLEQILS 251
SH3_Abl cd11850
Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase; Abl (or c-Abl) is a ...
93-147 9.68e-14

Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase; Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212784  Cd Length: 56  Bit Score: 65.90  E-value: 9.68e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKSGYIPSNYVVP 147
Cdd:cd11850   1 LFVALYDFVASGENQLSIKKGEQLRVLGyNKNGEWCEAESKSTGGQGWVPSNYITP 56
SH3_OSTF1 cd11772
Src Homology 3 domain of metazoan osteoclast stimulating factor 1; OSTF1, also named OSF or ...
93-147 1.12e-13

Src Homology 3 domain of metazoan osteoclast stimulating factor 1; OSTF1, also named OSF or SH3P2, is a signaling protein containing SH3 and ankyrin-repeat domains. It acts through a Src-related pathway to enhance the formation of osteoclasts and bone resorption. It also acts as a negative regulator of cell motility. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212706 [Multi-domain]  Cd Length: 53  Bit Score: 65.40  E-value: 1.12e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiaTGKSGYIPSNYVVP 147
Cdd:cd11772   1 VFRALYDYEAQHPDELSFEEGDLLYISDKSDPNWWKATC--GGKTGLIPSNYVEE 53
PK_STRAD_beta cd08226
Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain ...
316-516 1.16e-13

Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity.STRAD-beta is also referred to as ALS2CR2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein), since the human gene encoding it is located within the juvenile ALS2 critical region on chromosome 2q33-q34. It is not linked to the development of ALS2. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. The STRAD-beta subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270864 [Multi-domain]  Cd Length: 328  Bit Score: 72.21  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKL-RHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLK----EGDGKYLklpqLVDMAAQIADGMAYIERMN 389
Cdd:cd08226  46 LQNEVVLSHFfRHPNIMTHWTVFTEGSwLWVISPFMAYGSARGLLKtyfpEGMNEAL----IGNILYGAIKALNYLHQNG 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  390 YIHRDLRAANILV-GENLICKIADFGLARLIEDNEyTARQGAKFP------IKWTAPEAA---LYGrFTIKSDVWSFGIL 459
Cdd:cd08226 122 CIHRSVKASHILIsGDGLVSLSGLSHLYSMVTNGQ-RSKVVYDFPqfstsvLPWLSPELLrqdLHG-YNVKSDIYSVGIT 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  460 QTELVTkGRVPYPGMVNREVLEQVERG---------------YRM-------------------------------PCPQ 493
Cdd:cd08226 200 ACELAR-GQVPFQDMRRTQMLLQKLKGppyspldifpfpeleSRMknsqsgmdsgigesvatssmtrtmtserlqtPSSK 278
                       250       260
                ....*....|....*....|...
gi 6678617  494 GCPESLHELMNLCWKKDPDERPT 516
Cdd:cd08226 279 TFSPAFHNLVELCLQQDPEKRPS 301
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
273-487 1.17e-13

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 71.70  E-value: 1.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  273 ESLRLEVKLGQGCFGEVWMGTWNGTT--KVAIKTLKPGTMMPEAF--------LQEAQIMKKLRHDKLVPLYA-VVSEEP 341
Cdd:cd14096   1 ENYRLINKIGEGAFSNVYKAVPLRNTgkPVAIKVVRKADLSSDNLkgssraniLKEVQIMKRLSHPNIVKLLDfQESDEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  342 IYIVTEFMSKGSLLDflkegdgKYLKLPQLV-DMA----AQIADGMAYIERMNYIHRDLRAANILV-------------- 402
Cdd:cd14096  81 YYIVLELADGGEIFH-------QIVRLTYFSeDLSrhviTQVASAVKYLHEIGVVHRDIKPENLLFepipfipsivklrk 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  403 -------------------GENLICKIADFGLARLIEDNEytarqgAKFP---IKWTAPEAALYGRFTIKSDVWSFG-IL 459
Cdd:cd14096 154 adddetkvdegefipgvggGGIGIVKLADFGLSKQVWDSN------TKTPcgtVGYTAPEVVKDERYSKKVDMWALGcVL 227
                       250       260
                ....*....|....*....|....*...
gi 6678617  460 QTELVtkGRVPYPGMVNREVLEQVERGY 487
Cdd:cd14096 228 YTLLC--GFPPFYDESIETLTEKISRGD 253
SH3_Tec_like cd11768
Src Homology 3 domain of Tec-like Protein Tyrosine Kinases; The Tec (Tyrosine kinase expressed ...
93-147 1.20e-13

Src Homology 3 domain of Tec-like Protein Tyrosine Kinases; The Tec (Tyrosine kinase expressed in hepatocellular carcinoma) subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) tyr kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Most Tec subfamily members (except Rlk) also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. The function of Tec kinases in lymphoid cells have been studied extensively. They play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212702 [Multi-domain]  Cd Length: 54  Bit Score: 65.37  E-value: 1.20e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiATGKSGYIPSNYVVP 147
Cdd:cd11768   1 IVVALYDFQPIEPGDLPLEKGEEYVVLDDSNEHWWRARD-KNGNEGYIPSNYVTE 54
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
268-533 1.37e-13

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 71.24  E-value: 1.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEVKLGQGCFGEVW-MGTWNGTTKVAIKTLKPGTMMPEA--FLQEAQIMKKLRH-DKLVPLY-AVVSEEPI 342
Cdd:cd06616   1 YEFTAEDLKDLGEIGRGAFGTVNkMLHKPSGTIMAVKRIRSTVDEKEQkrLLMDLDVVMRSSDcPYIVKFYgALFREGDC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKgSLLDFLKEgdgKYLKLPQLV--DMAAQIAdgMAYIERMNY-------IHRDLRAANILVGENLICKIADF 413
Cdd:cd06616  81 WICMELMDI-SLDKFYKY---VYEVLDSVIpeEILGKIA--VATVKALNYlkeelkiIHRDVKPSNILLDRNGNIKLCDF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  414 GLA-RLIEDNEYTARQGAKfpiKWTAPE----AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMvnREVLEQVERGYR 488
Cdd:cd06616 155 GISgQLVDSIAKTRDAGCR---PYMAPEridpSASRDGYDVRSDVWSLGITLYEVAT-GKFPYPKW--NSVFDQLTQVVK 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  489 MPCPQGCPESLHE-------LMNLCWKKDPDERPTFEYIQS--FLEDYFTATEP 533
Cdd:cd06616 229 GDPPILSNSEEREfspsfvnFVNLCLIKDESKRPKYKELLKhpFIKMYEERNVD 282
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
275-530 1.48e-13

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 71.00  E-value: 1.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMP-EAFLQEAQIMKKLR-HDKLVPLYAVVS---EEPIYIVTEF 348
Cdd:cd14036   2 LRIKRVIAEGGFAFVYEAQDVGTgKEYALKRLLSNEEEKnKAIIQEINFMKKLSgHPNIVQFCSAASigkEESDQGQAEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  349 M-----SKGSLLDFLKE-GDGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILVGENLICKIADFGLAR--- 417
Cdd:cd14036  82 LlltelCKGQLVDFVKKvEAPGPFSPDTVLKIFYQTCRAVQHMHKQSppIIHRDLKIENLLIGNQGQIKLCDFGSATtea 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  418 LIEDNEYTARQGAKF---------PIkWTAPEAA-LYGRFTI--KSDVWSFGILQTELVTKgRVPYPgmvNREVLEQVER 485
Cdd:cd14036 162 HYPDYSWSAQKRSLVedeitrnttPM-YRTPEMIdLYSNYPIgeKQDIWALGCILYLLCFR-KHPFE---DGAKLRIINA 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6678617  486 GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTA 530
Cdd:cd14036 237 KYTIPPNDTQYTVFHDLIRSTLKVNPEERLSITEIVEQLQELAAA 281
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
317-516 1.75e-13

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 70.85  E-value: 1.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFMSKGSLLD------FLKEGDGKYLKlpqlvdmaaQIADGMAYIER 387
Cdd:cd14118  63 REIAILKKLDHPNVVKLVEVLddpNEDNLYMVFELVDKGAVMEvptdnpLSEETARSYFR---------DIVLGIEYLHY 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  388 MNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYGR--FTIKS-DVWSFGILQTELV 464
Cdd:cd14118 134 QKIIHRDIKPSNLLLGDDGHVKIADFGVSNEFEGDDALLSSTAGTP-AFMAPEALSESRkkFSGKAlDIWAMGVTLYCFV 212
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  465 TkGRVPYPGmVNREVLEQVERGYRMPCPQGC--PESLHELMNLCWKKDPDERPT 516
Cdd:cd14118 213 F-GRCPFED-DHILGLHEKIKTDPVVFPDDPvvSEQLKDLILRMLDKNPSERIT 264
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
281-516 1.80e-13

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 71.15  E-value: 1.80e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLK-PGTM--MPEAFLQEAQIMKKLR---HDKLVPLYAVV------SEEPIYIVTE 347
Cdd:cd07838   7 IGEGAYGTVYKARDLQDGRfVALKKVRvPLSEegIPLSTIREIALLKQLEsfeHPNVVRLLDVChgprtdRELKLTLVFE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLiedneYTaR 427
Cdd:cd07838  87 HVDQ-DLATYLDKCPKPGLPPETIKDLMRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLARI-----YS-F 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPIKWT----APEAALYGRFTIKSDVWSFGILQTELVTkgRVP-YPG--------------------------MVN 476
Cdd:cd07838 160 EMALTSVVVTlwyrAPEVLLQSSYATPVDMWSVGCIFAELFN--RRPlFRGsseadqlgkifdviglpseeewprnsALP 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6678617  477 REVLEQVERG-YRMPCPQGCPESLHeLMNLCWKKDPDERPT 516
Cdd:cd07838 238 RSSFPSYTPRpFKSFVPEIDEEGLD-LLKKMLTFNPHKRIS 277
PTK_Jak3_rpt1 cd14208
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is ...
281-520 2.34e-13

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit, common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. Jaks are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271110 [Multi-domain]  Cd Length: 260  Bit Score: 70.32  E-value: 2.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-------TKVAIKTLKP--GTMMpEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSK 351
Cdd:cd14208   7 LGKGSFTKIYRGLRTDEedderceTEVLLKVMDPthGNCQ-ESFLEAASIMSQISHKHLVLLHGVCVGKDSIMVQEFVCH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEgDGKYLKLPQ--LVDMAAQIADGMAYIERMNYIHRDLRAANILV------GENLICKIADFGLARLIEDNE 423
Cdd:cd14208  86 GALDLYLKK-QQQKGPVAIswKLQVVKQLAYALNYLEDKQLVHGNVSAKKVLLsregdkGSPPFIKLSDPGVSIKVLDEE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 YTARQgakfpIKWTAPEAALYGR-FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCpeSLHEL 502
Cdd:cd14208 165 LLAER-----IPWVAPECLSDPQnLALEADKWGFGATLWEIFSGGHMPLSALDPSKKLQFYNDRKQLPAPHWI--ELASL 237
                       250
                ....*....|....*...
gi 6678617  503 MNLCWKKDPDERPTFEYI 520
Cdd:cd14208 238 IQQCMSYNPLLRPSFRAI 255
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
268-516 2.64e-13

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 70.00  E-value: 2.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  268 WEIPRESLRLEV-KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYI- 344
Cdd:cd14113   1 WKDNFDSFYSEVaELGRGRFSVVKKCDQRGTKRaVATKFVNKKLMKRDQVTHELGVLQSLQHPQLVGLLDTFETPTSYIl 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKGSLLDF------LKEGDGK-YLKlpqlvdmaaQIADGMAYIERMNYIHRDLRAANILVGENL---ICKIADFG 414
Cdd:cd14113  81 VLEMADQGRLLDYvvrwgnLTEEKIRfYLR---------EILEALQYLHNCRIAHLDLKPENILVDQSLskpTIKLADFG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  415 LARLIeDNEYTARQGAKFPiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPY-PGMVNREVLEQVERGYRMPCP- 492
Cdd:cd14113 152 DAVQL-NTTYYIHQLLGSP-EFAAPEIILGNPVSLTSDLWSIGVL-TYVLLSGVSPFlDESVEETCLNICRLDFSFPDDy 228
                       250       260
                ....*....|....*....|....*
gi 6678617  493 -QGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14113 229 fKGVSQKAKDFVCFLLQMDPAKRPS 253
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
280-470 2.68e-13

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 70.90  E-value: 2.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGT---TKVAIKTLK---PGTMMPEAFLQEAQIMKKLR-HDKLVPLY--AVVSEEP---IYIVTE 347
Cdd:cd07857   7 ELGQGAYGIVCSARNAETseeETVAIKKITnvfSKKILAKRALRELKLLRHFRgHKNITCLYdmDIVFPGNfneLYLYEE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMsKGSLLDFLKEGDgkylklpQLVD-----MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDN 422
Cdd:cd07857  87 LM-EADLHQIIRSGQ-------PLTDahfqsFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSEN 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  423 ---------EYTArqgakfpIKW-TAPEAAL-YGRFTIKSDVWSFGILQTELVtkGRVP 470
Cdd:cd07857 159 pgenagfmtEYVA-------TRWyRAPEIMLsFQSYTKAIDVWSVGCILAELL--GRKP 208
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
318-527 2.73e-13

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 70.51  E-value: 2.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  318 EAQIMKKLRHDKLVPLYAVVSEE--PIYIVTEFMSKgSLLDFLKE----GDGKYlKLPQLVDMAAQIADGMAYIERMNYI 391
Cdd:cd14001  55 EAKILKSLNHPNIVGFRAFTKSEdgSLCLAMEYGGK-SLNDLIEEryeaGLGPF-PAATILKVALSIARALEYLHNEKKI 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 -HRDLRAANILV-GENLICKIADFGLA-RLIEDNEYTARQGAKF----PikWTAPEAALYGR-FTIKSDVWSFGILQTEL 463
Cdd:cd14001 133 lHGDIKSGNVLIkGDFESVKLCDFGVSlPLTENLEVDSDPKAQYvgteP--WKAKEALEEGGvITDKADIFAYGLVLWEM 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  464 VTKgRVPYPGMVNR----------EVLEQVE-----RGYRMPCPQGCP----ESLHELMNLCWKKDPDERPTFEYIQSFL 524
Cdd:cd14001 211 MTL-SVPHLNLLDIedddedesfdEDEEDEEayygtLGTRPALNLGELddsyQKVIELFYACTQEDPKDRPSAAHIVEAL 289

                ...
gi 6678617  525 EDY 527
Cdd:cd14001 290 EAH 292
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
313-516 2.82e-13

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 70.15  E-value: 2.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  313 EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMSKGSLLDFLKegdgKYLKLPQLVDMA--AQIADGMAYIERMN 389
Cdd:cd06630  48 EAIREEIRMMARLNHPNIVRMLGATQHKSHFnIFVEWMAGGSVASLLS----KYGAFSENVIINytLQILRGLAYLHDNQ 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  390 YIHRDLRAANILV---GENLicKIADFGLA-RLIEDNEYTAR-QGAKF-PIKWTAPE---AALYGRftiKSDVWSFGILQ 460
Cdd:cd06630 124 IIHRDLKGANLLVdstGQRL--RIADFGAAaRLASKGTGAGEfQGQLLgTIAFMAPEvlrGEQYGR---SCDVWSVGCVI 198
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  461 TELVTkGRVPYPgmvNREVLEQVERGYRMPCPQGCPE-------SLHELMNLCWKKDPDERPT 516
Cdd:cd06630 199 IEMAT-AKPPWN---AEKISNHLALIFKIASATTPPPipehlspGLRDVTLRCLELQPEDRPP 257
SH2_C-SH2_Zap70 cd10402
C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 ...
156-254 2.96e-13

C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70); ZAP-70 and Syk comprise a family of hematopoietic cell specific protein tyrosine kinases (PTKs) that are required for antigen and antibody receptor function. ZAP-70 is expressed in T and natural killer (NK) cells and Syk is expressed in B cells, mast cells, polymorphonuclear leukocytes, platelets, macrophages, and immature T cells. They are required for the proper development of T and B cells, immune receptors, and activating NK cells. They consist of two N-terminal Src homology 2 (SH2) domains and a C-terminal kinase domain separated from the SH2 domains by a linker or hinge region. Phosphorylation of both tyrosine residues within the Immunoreceptor Tyrosine-based Activation Motifs (ITAM; consensus sequence Yxx[LI]x(7,8)Yxx[LI]) by the Src-family PTKs is required for efficient interaction of ZAP-70 and Syk with the receptor subunits and for receptor function. ZAP-70 forms two phosphotyrosine binding pockets, one of which is shared by both SH2 domains. In Syk the two SH2 domains do not form such a phosphotyrosine-binding site. The SH2 domains here are believed to function independently. In addition, the two SH2 domains of Syk display flexibility in their relative orientation, allowing Syk to accommodate a greater variety of spacing sequences between the ITAM phosphotyrosines and singly phosphorylated non-classical ITAM ligands. This model contains the C-terminus SH2 domains of Zap70. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198265  Cd Length: 105  Bit Score: 66.10  E-value: 2.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTkGAYSLSIrdwdeVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd10402  12 WYHGSIARDEAERRLYSGAQPDGKFLLRERKES-GTYALSL-----VYGKTVYHYRIDQDKSGKYSIPEGTKFDTLWQLV 85
                        90
                ....*....|....*....
gi 6678617  236 KHYTEHADGLCHKLTTVCP 254
Cdd:cd10402  86 EYLKLKPDGLIFVLRESCP 104
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
281-473 3.00e-13

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 70.88  E-value: 3.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQEAQIMKKL-----RHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd05587   4 LGKGSFGKVMLAERKGTDELyAIKILKKDVIIQDDDVECTMVEKRVlalsgKPPFLTQLHSCFqTMDRLYFVMEYVNGGD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLdFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFP 433
Cdd:cd05587  84 LM-YHIQQVGKF-KEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEGIFGGKTTRTFCGTP 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6678617  434 iKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd05587 162 -DYIAPEIIAYQPYGKSVDWWAYGVLLYEMLA-GQPPFDG 199
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
281-515 3.04e-13

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 70.22  E-value: 3.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM--GTWNGTTKVAIKTLkpgTMMPEAFLQEAQ---------------IMKKLRHDKLVPLYAV-VSEEPI 342
Cdd:cd08528   8 LGSGAFGCVYKvrKKSNGQTLLALKEI---NMTNPAFGRTEQerdksvgdiisevniIKEQLRHPNIVRYYKTfLENDRL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFM---SKGSLLDFLKEGDGKYLKlPQLVDMAAQIADGMAYIERMNYI-HRDLRAANILVGENLICKIADFGLAR- 417
Cdd:cd08528  85 YIVMELIegaPLGEHFSSLKEKNEHFTE-DRIWNIFVQMVLALRYLHKEKQIvHRDLKPNNIMLGEDDKVTITDFGLAKq 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  418 -LIEDNEYTARQGAkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRmPCPQGC- 495
Cdd:cd08528 164 kGPESSKMTSVVGT---ILYSCPEIVQNEPYGEKADIWALGCILYQMCTLQPPFYSTNMLTLATKIVEAEYE-PLPEGMy 239
                       250       260
                ....*....|....*....|
gi 6678617  496 PESLHELMNLCWKKDPDERP 515
Cdd:cd08528 240 SDDITFVIRSCLTPDPEARP 259
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
281-416 3.11e-13

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 71.16  E-value: 3.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTM--MPE--AFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd05573   9 IGRGAFGEVWLVRDKDTGQVyAMKILRKSDMlkREQiaHVRAERDILADADSPWIVRLhYAFQDEDHLYLVMEYMPGGDL 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  355 LDFLKegdgKYLKLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA 416
Cdd:cd05573  89 MNLLI----KYDVFPE--ETArfyiAELVLALDSLHKLGFIHRDIKPDNILLDADGHIKLADFGLC 148
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
275-514 3.15e-13

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 70.13  E-value: 3.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMG----TWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-----AVVSEEPIYIV 345
Cdd:cd14031  12 LKFDIELGRGAFKTVYKGldteTWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYdswesVLKGKKCIVLV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEgdGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILV-GENLICKIADFGLARLIEDN 422
Cdd:cd14031  92 TELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFLHTRTppIIHRDLKCDNIFItGPTGSVKIGDLGLATLMRTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARQGAKfpiKWTAPEaaLYGRFTIKS-DVWSFGILQTELVTKgRVPYPGMVN-REVLEQVERGYRMPCPQGCPE-SL 499
Cdd:cd14031 170 FAKSVIGTP---EFMAPE--MYEEHYDESvDVYAFGMCMLEMATS-EYPYSECQNaAQIYRKVTSGIKPASFNKVTDpEV 243
                       250
                ....*....|....*
gi 6678617  500 HELMNLCWKKDPDER 514
Cdd:cd14031 244 KEIIEGCIRQNKSER 258
SH3_SLAP-like cd11848
Src homology 3 domain of Src-Like Adaptor Proteins; SLAPs are adaptor proteins with limited ...
95-145 3.31e-13

Src homology 3 domain of Src-Like Adaptor Proteins; SLAPs are adaptor proteins with limited similarity to Src family tyrosine kinases. They contain an N-terminal SH3 domain followed by an SH2 domain, and a unique C-terminal sequence. They function in regulating the signaling, ubiquitination, and trafficking of T-cell receptor (TCR) and B-cell receptor (BCR) components. Vertebrates contain two SLAPs, named SLAP (or SLA1) and SLAP2 (or SLA2). SLAP has been shown to interact with the EphA receptor, EpoR, Lck, PDGFR, Syk, CD79a, among others, while SLAP2 interacts with CSF1R. Both SLAPs interact with c-Cbl, LAT, CD247, and Zap70. SLAP modulates TCR surface expression levels as well as surface and total BCR levels. As an adaptor to c-Cbl, SLAP increases the ubiquitination, intracellular retention, and targeted degradation of the BCR complex components. SLAP2 plays a role in c-Cbl-dependent regulation of CSF1R, a tyrosine kinase important for myeloid cell growth and differentiation. The SH3 domain of SLAP forms a complex with v-Abl. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212782  Cd Length: 55  Bit Score: 64.13  E-value: 3.31e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNtEGDWWEARSIATGKSGYIPSNYV 145
Cdd:cd11848   3 VALGDYPSGGPAELSLRLGEPLTIVSD-EGDWWKVLSEVTGRESYIPSVHV 52
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
281-459 3.42e-13

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 69.66  E-value: 3.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPEAFLQEAQIMKKLR-HDKLVPLYAVVSEEPIYIV--TEFMSKGSLLD 356
Cdd:cd13987   1 LGEGTYGKVLLAVHKGSgTKMALKFVPKPSTKLKDFLREYNISLELSvHPHIIKTYDVAFETEDYYVfaQEYAPYGDLFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDGkylkLPQLV--DMAAQIADGMAYIERMNYIHRDLRAANILVGENlIC---KIADFGLAR----LIEDNEYTar 427
Cdd:cd13987  81 IIPPQVG----LPEERvkRCAAQLASALDFMHSKNLVHRDIKPENVLLFDK-DCrrvKLCDFGLTRrvgsTVKRVSGT-- 153
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6678617  428 qgakfpIKWTAPE---AALYGRFTIK--SDVWSFGIL 459
Cdd:cd13987 154 ------IPYTAPEvceAKKNEGFVVDpsIDVWAFGVL 184
SH3_Lck cd12005
Src homology 3 domain of Lck Protein Tyrosine Kinase; Lck is a member of the Src subfamily of ...
95-145 3.43e-13

Src homology 3 domain of Lck Protein Tyrosine Kinase; Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212938 [Multi-domain]  Cd Length: 54  Bit Score: 64.07  E-value: 3.43e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNtEGDWWEARSIATGKSGYIPSNYV 145
Cdd:cd12005   3 VALYSYEPSHDGDLGFEKGEKLRILEQ-SGEWWKAQSLTTGQEGFIPFNFV 52
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
280-468 3.52e-13

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 69.99  E-value: 3.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEV--WMGTWNGTtKVAIKT----LKPGTMmpEAFLQEAQIMKKLRHDKLVP-------LYAVVSEEPIYIVT 346
Cdd:cd14038   1 RLGTGGFGNVlrWINQETGE-QVAIKQcrqeLSPKNR--ERWCLEIQIMKRLNHPNVVAardvpegLQKLAPNDLPLLAM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEGDGKY-LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV--GEN-LICKIADFGLARLIEDN 422
Cdd:cd14038  78 EYCQGGDLRKYLNQFENCCgLREGAILTLLSDISSALRYLHENRIIHRDLKPENIVLqqGEQrLIHKIIDLGYAKELDQG 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  423 EY-TARQGAkfpIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGR 468
Cdd:cd14038 158 SLcTSFVGT---LQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFR 201
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
276-417 3.55e-13

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 69.79  E-value: 3.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKtLKPGTMMPEAFLQEAQIMKKLRHDKLVP-LYAVVSEEPI-YIVTEFMSKg 352
Cdd:cd14016   3 KLVKKIGSGSFGEVYLGIDLKTgEEVAIK-IEKKDSKHPQLEYEAKVYKLLQGGPGIPrLYWFGQEGDYnVMVMDLLGP- 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6678617  353 SLLDFLKEGDGKY-LKlpqlvdMAAQIADGMA----YIERMNYIHRDLRAANILVGENLICK---IADFGLAR 417
Cdd:cd14016  81 SLEDLFNKCGRKFsLK------TVLMLADQMIsrleYLHSKGYIHRDIKPENFLMGLGKNSNkvyLIDFGLAK 147
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
271-471 3.55e-13

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 70.05  E-value: 3.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  271 PRESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLK-PGTMMPEAFLQEAQIMKKLRHDKLVPLYA--VVSEEpIYIVT 346
Cdd:cd06657  18 PRTYLDNFIKIGEGSTGIVCIATVKSSGKlVAVKKMDlRKQQRRELLFNEVVIMRDYQHENVVEMYNsyLVGDE-LWVVM 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKGSLLDFLKEgdgKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDNEYTA 426
Cdd:cd06657  97 EFLEGGALTDIVTH---TRMNEEQIAAVCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPR 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6678617  427 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPY 471
Cdd:cd06657 173 RKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV-DGEPPY 216
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
281-473 3.70e-13

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 70.86  E-value: 3.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTT-KVAIKTLKpgtmmpEAF---------LQEAQIMKKLRHDKLVPLYAVV------SEEPIYI 344
Cdd:cd07858  13 IGRGAYGIVCSAKNSETNeKVAIKKIA------NAFdnridakrtLREIKLLRHLDHENVIAIKDIMppphreAFNDVYI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFM---------SKGSLLD-----FLkegdgkYlklpqlvdmaaQIADGMAYIERMNYIHRDLRAANILVGENLICKI 410
Cdd:cd07858  87 VYELMdtdlhqiirSSQTLSDdhcqyFL------Y-----------QLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 149
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  411 ADFGLARLIEDN-----EYTARQgakfpiKWTAPEAAL-YGRFTIKSDVWSFGILQTELVtkGRVP-YPG 473
Cdd:cd07858 150 CDFGLARTTSEKgdfmtEYVVTR------WYRAPELLLnCSEYTTAIDVWSVGCIFAELL--GRKPlFPG 211
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
316-537 3.85e-13

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 70.46  E-value: 3.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEGDgkylKLPQ--LVDMAAQIADGMAYI-ERMNYI 391
Cdd:cd06649  51 IRELQVLHECNSPYIVGFYgAFYSDGEISICMEHMDGGSLDQVLKEAK----RIPEeiLGKVSIAVLRGLAYLrEKHQIM 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd06649 127 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVELAI-GRYPI 202
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  472 P--------GMVNREVLEQVE-RGYRM---PCPQGCPESLHELmnlcwkkdpDERPTFEYIQsfLEDYFTATEPQYQP 537
Cdd:cd06649 203 PppdakeleAIFGRPVVDGEEgEPHSIsprPRPPGRPVSGHGM---------DSRPAMAIFE--LLDYIVNEPPPKLP 269
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
280-485 4.05e-13

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 70.39  E-value: 4.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEV---WMGTWNGTTKVAIKTLKP----GTMMPEAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFM 349
Cdd:cd07842   7 CIGRGTYGRVykaKRKNGKDGKEYAIKKFKGdkeqYTGISQSACREIALLRELKHENVVSLVEVFlehADKSVYLLFDYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SK--GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-GENLIC---KIADFGLARLIEDne 423
Cdd:cd07842  87 EHdlWQIIKFHRQAKRVSIPPSMVKSLLWQILNGIHYLHSNWVLHRDLKPANILVmGEGPERgvvKIGDLGLARLFNA-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  424 ytarqgakfPIK------------W-TAPEAALYGR-FTIKSDVWSFGILQTELVT------------KGRVPYPgmvnr 477
Cdd:cd07842 165 ---------PLKpladldpvvvtiWyRAPELLLGARhYTKAIDIWAIGCIFAELLTlepifkgreakiKKSNPFQ----- 230

                ....*...
gi 6678617  478 evLEQVER 485
Cdd:cd07842 231 --RDQLER 236
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
278-473 4.57e-13

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 70.42  E-value: 4.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  278 EVK--LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFM 349
Cdd:cd05601   4 EVKnvIGRGHFGEVQVVKEKATGDIyAMKVLKKSETLAQEevsfFEEERDIMAKANSPWITKLqYAFQDSENLYLVMEYH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGDGKYLKlpqlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG-LARLIEDNEY 424
Cdd:cd05601  84 PGGDLLSLLSRYDDIFEE-----SMArfylAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGsAAKLSSDKTV 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  425 TarqgAKFPI---KWTAPE--AALYGRFT----IKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd05601 159 T----SKMPVgtpDYIAPEvlTSMNGGSKgtygVECDWWSLGIVAYEMLY-GKTPFTE 211
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
281-471 4.94e-13

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 69.40  E-value: 4.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGT-TKVAIKTLK---PGTMMPEAFLQ-------------EAQIMKKLRHDKLVPLYAVV-SEEPI 342
Cdd:cd14077   9 IGAGSMGKVKLAKHIRTgEKCAIKIIPrasNAGLKKEREKRlekeisrdirtirEAALSSLLNHPHICRLRDFLrTPNHY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEgDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIeDN 422
Cdd:cd14077  89 YMLFEYVDGGQLLDYIIS-HGK-LKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGLSNLY-DP 165
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617  423 EytaRQGAKF--PIKWTAPEAALYGRFT-IKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd14077 166 R---RLLRTFcgSLYFAAPELLQAQPYTgPEVDVWSFGVVLYVLVC-GKVPF 213
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
281-485 4.98e-13

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 69.55  E-value: 4.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVW------MGTWNGTTKVAIKTLKPGTMMPEAFLqEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGS 353
Cdd:cd05607  10 LGKGGFGEVCavqvknTGQMYACKKLDKKRLKKKSGEKMALL-EKEILEKVNSPFIVSLaYAFETKTHLCLVMSLMNGGD 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA-RLIEDNEYTARQGAKf 432
Cdd:cd05607  89 LKYHIYNVGERGIEMERVIFYSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAvEVKEGKPITQRAGTN- 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617  433 piKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER 485
Cdd:cd05607 168 --GYMAPEILKEESYSYPVDWFAMGCSIYEMVA-GRTPFRDHKEKVSKEELKR 217
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
281-490 5.95e-13

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 69.35  E-value: 5.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd14209   9 LGTGSFGRVMLVRHKETGNyYAMKILDKQKVVKlkqvEHTLNEKRILQAINFPFLVKLeYSFKDNSNLYMVMEYVPGGEM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFLKEgDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTArqgAKFPi 434
Cdd:cd14209  89 FSHLRR-IGRFSE-PHARFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKRVKGRTWTL---CGTP- 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  435 KWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMP 490
Cdd:cd14209 163 EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGkVRFP 218
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
277-522 6.63e-13

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 68.98  E-value: 6.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGT-TKVAIKTL---KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSK 351
Cdd:cd14074   7 LEETLGRGHFAVVKLARHVFTgEKVAVKVIdktKLDDVSKAHLFQEVRCMKLVQHPNVVRLYEVIdTQTKLYLILELGDG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKylkLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLIC-KIADFGLARLIEDNEYTa 426
Cdd:cd14074  87 GDMYDYIMKHENG---LNE--DLArkyfRQIVSAISYCHKLHVVHRDLKPENVVFFEKQGLvKLTDFGFSNKFQPGEKL- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 rQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVergyrMPCPQGCPESLHE---- 501
Cdd:cd14074 161 -ETSCGSLAYSAPEILLGDEYDApAVDIWSLGVILYMLVC-GQPPFQEANDSETLTMI-----MDCKYTVPAHVSPeckd 233
                       250       260
                ....*....|....*....|.
gi 6678617  502 LMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14074 234 LIRRMLIRDPKKRASLEEIEN 254
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
279-528 6.79e-13

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 68.97  E-value: 6.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  279 VKLGQGCFGEVWMG-TWNGTTKVAIKTLkpgtmmPEAFLQEAQ-------IMKKLRHDKLVPLYAVVSEEPIY-IVTEFM 349
Cdd:cd06624  14 VVLGKGTFGVVYAArDLSTQVRIAIKEI------PERDSREVQplheeiaLHSRLSHKNIVQYLGSVSEDGFFkIFMEQV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLKEGDGkylklPQLVDMAA------QIADGMAYIERMNYIHRDLRAANILVGE-NLICKIADFGLA-RLIED 421
Cdd:cd06624  88 PGGSLSALLRSKWG-----PLKDNENTigyytkQILEGLKYLHDNKIVHRDIKGDNVLVNTySGVVKISDFGTSkRLAGI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTarQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRM--PCPQGCPE 497
Cdd:cd06624 163 NPCT--ETFTGTLQYMAPEVIDKGQrgYGPPADIWSLGCTIIEMAT-GKPPFIELGEPQAAMFKVGMFKIhpEIPESLSE 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 6678617  498 SLHELMNLCWKKDPDERPTfeyIQSFLEDYF 528
Cdd:cd06624 240 EAKSFILRCFEPDPDKRAT---ASDLLQDPF 267
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
318-459 6.98e-13

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 68.89  E-value: 6.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  318 EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGdGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLR 396
Cdd:cd14095  48 EVAILRRVKHPNIVQLIEEYdTDTELYLVMELVKGGDLFDAITSS-TKFTE-RDASRMVTDLAQALKYLHSLSIVHRDIK 125
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6678617  397 AANILVGEN----LICKIADFGLARLIEDNEYTArqgAKFPiKWTAPEAALYGRFTIKSDVWSFGIL 459
Cdd:cd14095 126 PENLLVVEHedgsKSLKLADFGLATEVKEPLFTV---CGTP-TYVAPEILAETGYGLKVDIWAAGVI 188
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
281-483 7.29e-13

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 70.01  E-value: 7.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   281 LGQGCFGEVWMGTWNGTT--KVAIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPLYAVVSEEP-IYIVTEFMSKGS 353
Cdd:PTZ00426  38 LGTGSFGRVILATYKNEDfpPVAIKRFEKSKIIKQKqvdhVFSERKILNYINHPFCVNLYGSFKDESyLYLVLEFVIGGE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   354 LLDFLKEGDgkylKLPQLVD--MAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAK 431
Cdd:PTZ00426 118 FFTFLRRNK----RFPNDVGcfYAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAKVVDTRTYTLCGTPE 193
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617   432 FpikwTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY----PGMVNREVLEQV 483
Cdd:PTZ00426 194 Y----IAPEILLNVGHGKAADWWTLGIFIYEILV-GCPPFyanePLLIYQKILEGI 244
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
313-518 7.42e-13

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 68.78  E-value: 7.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  313 EAFLQEAQIMKKLRH-DKLVPLY-AVVSEEP--IYIVTEFmSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERM 388
Cdd:cd14131  44 QSYKNEIELLKKLKGsDRIIQLYdYEVTDEDdyLYMVMEC-GEIDLATILKKKRPKPIDPNFIRYYWKQMLEAVHTIHEE 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  389 NYIHRDLRAAN-ILVGENLicKIADFGLARLIEDNEYT----ARQGAkfpIKWTAPEAALYGRFTI----------KSDV 453
Cdd:cd14131 123 GIVHSDLKPANfLLVKGRL--KLIDFGIAKAIQNDTTSivrdSQVGT---LNYMSPEAIKDTSASGegkpkskigrPSDV 197
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  454 WSFG-ILQteLVTKGRVPYPGMVNreVLEQVER----GYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14131 198 WSLGcILY--QMVYGKTPFQHITN--PIAKLQAiidpNHEIEFPDIPNPDLIDVMKRCLQRDPKKRPSIP 263
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
277-518 8.18e-13

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 68.76  E-value: 8.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  277 LEVKLGQGCFGEVWMGTWNGTTK-VAIKTL-KPGTMMPEAFLQ-EAQIMKKLRHDKLVPLYAVVsEEP--IYIVTEFMSK 351
Cdd:cd14169   7 LKEKLGEGAFSEVVLAQERGSQRlVALKCIpKKALRGKEAMVEnEIAVLRRINHENIVSLEDIY-ESPthLYLAMELVTG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEgDGKYLK--LPQLVdmaAQIADGMAYIERMNYIHRDLRAANILVG---ENLICKIADFGLARLIEDNEYTA 426
Cdd:cd14169  86 GELFDRIIE-RGSYTEkdASQLI---GQVLQAVKYLHQLGIVHRDLKPENLLYAtpfEDSKIMISDFGLSKIEAQGMLST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  427 RQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERG-YRMPCP--QGCPESLHELM 503
Cdd:cd14169 162 ACGTP---GYVAPELLEQKPYGKAVDVWAIGVISYILLC-GYPPFYDENDSELFNQILKAeYEFDSPywDDISESAKDFI 237
                       250
                ....*....|....*
gi 6678617  504 NLCWKKDPDERPTFE 518
Cdd:cd14169 238 RHLLERDPEKRFTCE 252
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
281-459 8.67e-13

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 68.88  E-value: 8.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVW----MGTWNgttKVAIKTLKPGTMMPEA--------FLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVT-- 346
Cdd:cd13990   8 LGKGGFSEVYkafdLVEQR---YVACKIHQLNKDWSEEkkqnyikhALREYEIHKSLDHPRIVKLYDVFEIDTDSFCTvl 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFmSKGSLLDF-LKEGDGKYLKLPQLVDMaaQIADGMAYIE--RMNYIHRDLRAANILVGENLIC---KIADFGLARLIE 420
Cdd:cd13990  85 EY-CDGNDLDFyLKQHKSIPEREARSIIM--QVVSALKYLNeiKPPIIHYDLKPGNILLHSGNVSgeiKITDFGLSKIMD 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 DNEYTA------RQGAKfpIKW-TAPEAALYG----RFTIKSDVWSFGIL 459
Cdd:cd13990 162 DESYNSdgmeltSQGAG--TYWyLPPECFVVGktppKISSKVDVWSVGVI 209
STKc_IRAK2 cd14157
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 2; ...
283-465 8.89e-13

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK2 plays a role in mediating NFkB activation by TLR3, TLR4, and TLR8. It is specifically targeted by the viral protein A52, which is important for virulence, to inhibit all IL-1/TLR pathways, indicating that IRAK2 has a predominant role in NFkB activation. It is redundant with IRAK1 in early signaling but is critical for late and sustained activation. The IRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271059 [Multi-domain]  Cd Length: 289  Bit Score: 69.10  E-value: 8.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  283 QGCFGEVWMGtWNGTTKVAIKTLK------PGTMmpEAFLQ-EAQIMKKLRHDKLVPL--YAVVSEEPIYIvTEFMSKGS 353
Cdd:cd14157   3 EGTFADIYKG-YRHGKQYVIKRLKetecesPKST--ERFFQtEVQICFRCCHPNILPLlgFCVESDCHCLI-YPYMPNGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLK-EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLaRLIEDNEYTARQGAKF 432
Cdd:cd14157  79 LQDRLQqQGGSHPLPWEQRLSISLGLLKAVQHLHNFGILHGNIKSSNVLLDGNLLPKLGHSGL-RLCPVDKKSVYTMMKT 157
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6678617  433 PIKWTA----PEAAL-YGRFTIKSDVWSFGILQTELVT 465
Cdd:cd14157 158 KVLQISlaylPEDFVrHGQLTEKVDIFSCGVVLAEILT 195
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
318-522 9.14e-13

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 68.52  E-value: 9.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  318 EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDgKYLKLPQLVdMAAQIADGMAYIERMNYIHRDLR 396
Cdd:cd14184  49 EVSILRRVKHPNIIMLIEEMdTPAELYLVMELVKGGDLFDAITSST-KYTERDASA-MVYNLASALKYLHGLCIVHRDIK 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  397 AANILVGE----NLICKIADFGLARLIEDNEYTArqgAKFPiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYP 472
Cdd:cd14184 127 PENLLVCEypdgTKSLKLGDFGLATVVEGPLYTV---CGTP-TYVAPEIIAETGYGLKVDIWAAGVI-TYILLCGFPPFR 201
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  473 GMVN--REVLEQVERGY-RMPCP--QGCPESLHELMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14184 202 SENNlqEDLFDQILLGKlEFPSPywDNITDSAKELISHMLQVNVEARYTAEQILS 256
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
280-518 9.17e-13

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 68.80  E-value: 9.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTKV-AIKTLKP---GTMMPEAFLQEAQIMKKLRHD-KLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd14198  15 ELGRGKFAVVRQCISKSTGQEyAAKFLKKrrrGQDCRAEILHEIAVLELAKSNpRVVNLHEVYeTTSEIILILEYAAGGE 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL------VGEnliCKIADFGLARLIEdNEYTAR 427
Cdd:cd14198  95 IFNLCVPDLAEMVSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILlssiypLGD---IKIVDFGMSRKIG-HACELR 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREV---LEQVERGYRMPCPQGCPESLHELMN 504
Cdd:cd14198 171 EIMGTP-EYLAPEILNYDPITTATDMWNIGVIAYMLLT-HESPFVGEDNQETflnISQVNVDYSEETFSSVSQLATDFIQ 248
                       250
                ....*....|....
gi 6678617  505 LCWKKDPDERPTFE 518
Cdd:cd14198 249 KLLVKNPEKRPTAE 262
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
316-537 1.16e-12

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 68.93  E-value: 1.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  316 LQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEGDgkylKLPQLVDMAAQIA--DGMAYI-ERMNYI 391
Cdd:cd06650  51 IRELQVLHECNSPYIVGFYgAFYSDGEISICMEHMDGGSLDQVLKKAG----RIPEQILGKVSIAviKGLTYLrEKHKIM 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  392 HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd06650 127 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPI 202
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  472 PGMVNREvLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQsfLEDYFTATEPQYQP 537
Cdd:cd06650 203 PPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE--LLDYIVNEPPPKLP 265
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
276-484 1.17e-12

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 69.04  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGTWNGT-TKVAIKTLKpgtmmpEAF---------LQEAQIMKKLRHDKLVPLYAVV------SE 339
Cdd:cd07859   3 KIQEVIGKGSYGVVCSAIDTHTgEKVAIKKIN------DVFehvsdatriLREIKLLRLLRHPDIVEIKHIMlppsrrEF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  340 EPIYIVTEFMsKGSLLDFLKEGDGKYLKLPQLvdMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI 419
Cdd:cd07859  77 KDIYVVFELM-ESDLHQVIKANDDLTPEHHQF--FLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVA 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  420 EDNEYTArqgakfpIKWT---------APE--AALYGRFTIKSDVWSFGILQTELVTkGRVPYPGmvnREVLEQVE 484
Cdd:cd07859 154 FNDTPTA-------IFWTdyvatrwyrAPElcGSFFSKYTPAIDIWSIGCIFAEVLT-GKPLFPG---KNVVHQLD 218
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
281-479 1.22e-12

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 68.87  E-value: 1.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMP----EAFLQEAQIMK---KLRHDKLVPLYAVV-SEEPIYIVTEFMSK 351
Cdd:cd05589   7 LGRGHFGKVLLAEYKPTGELfAIKALKKGDIIArdevESLMCEKRIFEtvnSARHPFLVNLFACFqTPEHVCFVMEYAAG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLL-----DFLKEgdgkylklPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARliEDNEYTA 426
Cdd:cd05589  87 GDLMmhiheDVFSE--------PRAVFYAACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK--EGMGFGD 156
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  427 RQGAkF---PiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPG---------MVNREV 479
Cdd:cd05589 157 RTST-FcgtP-EFLAPEVLTDTSYTRAVDWWGLGVLIYEMLV-GESPFPGddeeevfdsIVNDEV 218
SH3_Nck_3 cd11767
Third Src Homology 3 domain of Nck adaptor proteins; This group contains the third SH3 domain ...
95-145 1.29e-12

Third Src Homology 3 domain of Nck adaptor proteins; This group contains the third SH3 domain of Nck, the first SH3 domain of Caenorhabditis elegans Ced-2 (Cell death abnormality protein 2), and similar domains. Nck adaptor proteins regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates. They contain three SH3 domains and a C-terminal SH2 domain. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics. Vertebrates contain two Nck adaptor proteins: Nck1 (also called Nckalpha) and Nck2 (also called Nckbeta or Growth factor receptor-bound protein 4, Grb4), which show partly overlapping functions but also bind distinct targets. Their SH3 domains are involved in recruiting downstream effector molecules, such as the N-WASP/Arp2/3 complex, which when activated induces actin polymerization that results in the production of pedestals, or protrusions of the plasma membrane. The third SH3 domain of Nck appears to prefer ligands with a PxAPxR motif. SH3 domains are protein interaction domains that usually bind to proline-rich ligands with moderate affinity and selectivity, preferentially a PxxP motif. Ced-2 is a cell corpse engulfment protein that interacts with Ced-5 in a pathway that regulates the activation of Ced-10, a Rac small GTPase.


Pssm-ID: 212701 [Multi-domain]  Cd Length: 56  Bit Score: 62.33  E-value: 1.29e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNTEGD--WWEARSiATGKSGYIPSNYV 145
Cdd:cd11767   3 VALYPFTGENDEELSFEKGERLEIIEKPEDDpdWWKARN-ALGTTGLVPRNYV 54
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
281-466 1.38e-12

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 67.90  E-value: 1.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKpgtMMPEAFLQEAQIMKKLRHDKLVPLY-----------------AVVSEEPI 342
Cdd:cd14047  14 IGSGGFGQVFKAKHRIDGKTyAIKRVK---LNNEKAEREVKALAKLDHPNIVRYNgcwdgfdydpetsssnsSRSKTKCL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  343 YIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGL-ARLIED 421
Cdd:cd14047  91 FIQMEFCEKGTLESWIEKRNGEKLDKVLALEIFEQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFGLvTSLKND 170
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6678617  422 NEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTK 466
Cdd:cd14047 171 GKRTKSKGTL---SYMSPEQISSQDYGKEVDIYALGLILFELLHV 212
SH3_Bem1p_1 cd11878
First Src Homology 3 domain of Bud emergence protein 1 and similar domains; Members of this ...
96-144 1.99e-12

First Src Homology 3 domain of Bud emergence protein 1 and similar domains; Members of this subfamily bear similarity to Saccharomyces cerevisiae Bem1p, containing two Src Homology 3 (SH3) domains at the N-terminus, a central PX domain, and a C-terminal PB1 domain. Bem1p is a scaffolding protein that is critical for proper Cdc42p activation during bud formation in yeast. During budding and mating, Bem1p migrates to the plasma membrane where it can serve as an adaptor for Cdc42p and some other proteins. Bem1p also functions as an effector of the G1 cyclin Cln3p and the cyclin-dependent kinase Cdc28p in promoting vacuolar fusion. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.


Pssm-ID: 212811 [Multi-domain]  Cd Length: 54  Bit Score: 61.92  E-value: 1.99e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617   96 ALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKSGYIPSNY 144
Cdd:cd11878   4 ALYDYRAQTPGELSFSKGDFFHVIGeEDQGEWYEATNPVTGKRGLVPKSY 53
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
281-473 2.04e-12

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 68.40  E-value: 2.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMP----EAFLQEAQIMKK-LRHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd05570   3 LGKGSFGKVMLAERKKTDELyAIKVLKKEVIIEdddvECTMTEKRVLALaNRHPFLTGLHACFqTEDRLYFVMEYVNGGD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLdFLKEGDGKYlKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR--LIEDNeyTARQGAK 431
Cdd:cd05570  83 LM-FHIQRARRF-TEERARFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKegIWGGN--TTSTFCG 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6678617  432 FPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPG 473
Cdd:cd05570 159 TP-DYIAPEILREQDYGFSVDWWALGVLLYEMLA-GQSPFEG 198
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
276-526 2.29e-12

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 67.13  E-value: 2.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWM-GTWNGTTKVAIKTLKPgtmmPEA-----FLQEAQIMKKL-RHDKLVPLYAVV--------SEE 340
Cdd:cd13975   3 KLGRELGRGQYGVVYAcDSWGGHFPCALKSVVP----PDDkhwndLALEFHYTRSLpKHERIVSLHGSVidysygggSSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 PIYIVTEFMSKgSLLDFLKEGdgkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARlIE 420
Cdd:cd13975  79 AVLLIMERLHR-DLYTGIKAG----LSLEERLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCK-PE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  421 DNEYTARQGAkfPIKwTAPEaALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNR-----EVLEQVERGYRmpcPQGC 495
Cdd:cd13975 153 AMMSGSIVGT--PIH-MAPE-LFSGKYDNSVDVYAFGILFWYLCA-GHVKLPEAFEQcaskdHLWNNVRKGVR---PERL 224
                       250       260       270
                ....*....|....*....|....*....|....
gi 6678617  496 P---ESLHELMNLCWKKDPDERPTFEYIQSFLED 526
Cdd:cd13975 225 PvfdEECWNLMEACWSGDPSQRPLLGIVQPKLQG 258
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
280-463 2.31e-12

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 67.75  E-value: 2.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGT--WNGTTKVAIKTLKPGTM---MPEAFLQEAQIMKKLR---HDKLVPLYAVVS------EEPIYIV 345
Cdd:cd07862   8 EIGEGAYGKVFKARdlKNGGRFVALKRVRVQTGeegMPLSTIREVAVLRHLEtfeHPNVVRLFDVCTvsrtdrETKLTLV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNeyT 425
Cdd:cd07862  88 FEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--M 164
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6678617  426 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTEL 463
Cdd:cd07862 165 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM 202
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
275-514 2.44e-12

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 67.41  E-value: 2.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMG----TWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-----AVVSEEPIYIV 345
Cdd:cd14032   3 LKFDIELGRGSFKTVYKGldteTWVEVAWCELQDRKLTKVERQRFKEEAEMLKGLQHPNIVRFYdfwesCAKGKRCIVLV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEgdGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILV-GENLICKIADFGLARLIEDN 422
Cdd:cd14032  83 TELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLLFLHTRTppIIHRDLKCDNIFItGPTGSVKIGDLGLATLKRAS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARQGAKfpiKWTAPEaaLYGRFTIKS-DVWSFGILQTELVTKgRVPYPGMVN-REVLEQVERGYRMPCPQGC--PEs 498
Cdd:cd14032 161 FAKSVIGTP---EFMAPE--MYEEHYDESvDVYAFGMCMLEMATS-EYPYSECQNaAQIYRKVTCGIKPASFEKVtdPE- 233
                       250
                ....*....|....*.
gi 6678617  499 LHELMNLCWKKDPDER 514
Cdd:cd14032 234 IKEIIGECICKNKEER 249
SH3_SLAP2 cd12011
Src homology 3 domain of Src-Like Adaptor Protein 2; SLAP2 plays a role in c-Cbl-dependent ...
93-145 2.73e-12

Src homology 3 domain of Src-Like Adaptor Protein 2; SLAP2 plays a role in c-Cbl-dependent regulation of CSF1R, a tyrosine kinase important for myeloid cell growth and differentiation. It has been shown to interact with CSF1R, c-Cbl, LAT, CD247, and Zap70. SLAPs are adaptor proteins with limited similarity to Src family tyrosine kinases. They contain an N-terminal SH3 domain followed by an SH2 domain, and a unique C-terminal sequence. They function in regulating the signaling, ubiquitination, and trafficking of T-cell receptor (TCR) and B-cell receptor (BCR) components. The SH3 domain of SLAP forms a complex with v-Abl. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212944  Cd Length: 55  Bit Score: 61.68  E-value: 2.73e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNtEGDWWEARSIATGKSGYIPSNYV 145
Cdd:cd12011   1 VAVALCNFPSGGPTELSIRMGEQLTILSE-DGDWWKVSSAVTGRECYIPSNYV 52
SH3_BTK cd11906
Src Homology 3 domain of Bruton's tyrosine kinase; BTK is a cytoplasmic (or nonreceptor) tyr ...
95-146 3.19e-12

Src Homology 3 domain of Bruton's tyrosine kinase; BTK is a cytoplasmic (or nonreceptor) tyr kinase containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212839 [Multi-domain]  Cd Length: 55  Bit Score: 61.38  E-value: 3.19e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiATGKSGYIPSNYVV 146
Cdd:cd11906   4 VALYDYTPMNAQDLQLRKGEEYVILEESNLPWWRARD-KNGREGYIPSNYVT 54
SH2_N-SH2_SHP_like cd10340
N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; The ...
156-241 3.41e-12

N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; The SH2 domain phosphatases (SHP-1, SHP-2/Syp, Drosophila corkscrew (csw), and Caenorhabditis elegans Protein Tyrosine Phosphatase (Ptp-2)) are cytoplasmic signaling enzymes. They are both targeted and regulated by interactions of their SH2 domains with phosphotyrosine docking sites. These proteins contain two SH2 domains (N-SH2, C-SH2) followed by a tyrosine phosphatase (PTP) domain, and a C-terminal extension. Shp1 and Shp2 have two tyrosyl phosphorylation sites in their C-tails, which are phosphorylated differentially by receptor and nonreceptor PTKs. Csw retains the proximal tyrosine and Ptp-2 lacks both sites. Shp-binding proteins include receptors, scaffolding adapters, and inhibitory receptors. Some of these bind both Shp1 and Shp2 while others bind only one. Most proteins that bind a Shp SH2 domain contain one or more immuno-receptor tyrosine-based inhibitory motifs (ITIMs): [IVL]xpYxx[IVL]. Shp1 N-SH2 domain blocks the catalytic domain and keeps the enzyme in the inactive conformation, and is thus believed to regulate the phosphatase activity of SHP-1. Its C-SH2 domain is thought to be involved in searching for phosphotyrosine activators. The SHP2 N-SH2 domain is a conformational switch; it either binds and inhibits the phosphatase, or it binds phosphoproteins and activates the enzyme. The C-SH2 domain contributes binding energy and specificity, but it does not have a direct role in activation. Csw SH2 domain function is essential, but either SH2 domain can fulfill this requirement. The role of the csw SH2 domains during Sevenless receptor tyrosine kinase (SEV) signaling is to bind Daughter of Sevenless rather than activated SEV. Ptp-2 acts in oocytes downstream of sheath/oocyte gap junctions to promote major sperm protein (MSP)-induced MAP Kinase (MPK-1) phosphorylation. Ptp-2 functions in the oocyte cytoplasm, not at the cell surface to inhibit multiple RasGAPs, resulting in sustained Ras activation. It is thought that MSP triggers PTP-2/Ras activation and ROS production to stimulate MPK-1 activity essential for oocyte maturation and that secreted MSP domains and Cu/Zn superoxide dismutases function antagonistically to control ROS and MAPK signaling. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198203  Cd Length: 99  Bit Score: 62.80  E-value: 3.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQrGIFLVRESETTKGAYSLSIRdwdevRGDNVKHYKIRKldNGGYY-ITTRAQFDTLQKL 234
Cdd:cd10340   2 WFHPVISGIEAENLLKTRGVD-GSFLARPSKSNPGDFTLSVR-----RGDEVTHIKIQN--TGDYYdLYGGEKFATLSEL 73

                ....*..
gi 6678617  235 VKHYTEH 241
Cdd:cd10340  74 VQYYMEQ 80
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
278-516 3.49e-12

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 66.84  E-value: 3.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  278 EVK--LGQGCFGEVWMGTWNGTTKVAIKTLKP--GTMMPEAFlQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKG 352
Cdd:cd14107   5 EVKeeIGRGTFGFVKRVTHKGNGECCAAKFIPlrSSTRARAF-QERDILARLSHRRLTCLLDQFEtRKTLILILELCSSE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  353 SLLD--FLK----EGDGK-YLKlpqlvdmaaQIADGMAYIERMNYIHRDLRAANILV----GENLicKIADFGLARLIED 421
Cdd:cd14107  84 ELLDrlFLKgvvtEAEVKlYIQ---------QVLEGIGYLHGMNILHLDIKPDNILMvsptREDI--KICDFGFAQEITP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYtarQGAKF--PiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYPGMVNREVLEQVERG---YRMPCPQGCP 496
Cdd:cd14107 153 SEH---QFSKYgsP-EFVAPEIVHQEPVSAATDIWALGVI-AYLSLTCHSPFAGENDRATLLNVAEGvvsWDTPEITHLS 227
                       250       260
                ....*....|....*....|
gi 6678617  497 ESLHELMNLCWKKDPDERPT 516
Cdd:cd14107 228 EDAKDFIKRVLQPDPEKRPS 247
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
281-485 4.20e-12

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 67.00  E-value: 4.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTL-------KPGTMMPeafLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSK 351
Cdd:cd05605   8 LGKGGFGEVCACQVRATGKMyACKKLekkrikkRKGEAMA---LNEKQILEKVNSRFVVSLaYAYETKDALCLVLTIMNG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEyTARqGAK 431
Cdd:cd05605  85 GDLKFHIYNMGNPGFEEERAVFYAAEITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPEGE-TIR-GRV 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6678617  432 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVER 485
Cdd:cd05605 163 GTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIE-GQAPFRARKEKVKREEVDR 215
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
272-518 4.31e-12

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 66.99  E-value: 4.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKTL-KPGTMMPEAFLQ-EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTE 347
Cdd:cd14168   9 KKIFEFKEVLGTGAFSEVVLAEERATGKLfAVKCIpKKALKGKESSIEnEIAVLRKIKHENIVALEDIYeSPNHLYLVMQ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  348 FMSKGSLLDFLKEgDGKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV---GENLICKIADFGLARLiEDNEY 424
Cdd:cd14168  89 LVSGGELFDRIVE-KGFYTE-KDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYfsqDEESKIMISDFGLSKM-EGKGD 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TARQGAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV---ERGYRMPCPQGCPESLHE 501
Cdd:cd14168 166 VMSTACGTP-GYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQIlkaDYEFDSPYWDDISDSAKD 243
                       250
                ....*....|....*..
gi 6678617  502 LMNLCWKKDPDERPTFE 518
Cdd:cd14168 244 FIRNLMEKDPNKRYTCE 260
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
281-514 4.67e-12

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 67.02  E-value: 4.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEAFLQEAQIMKKL-----RHDKLVPLYAVV-SEEPIYIVTEFMSKGS 353
Cdd:cd05592   3 LGKGSFGKVMLAELKGTNQYfAIKALKKDVVLEDDDVECTMIERRVlalasQHPFLTHLFCTFqTESHLFFVMEYLNGGD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLdFLKEGDGKYlklpqlvDM------AAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLiedNEYTAR 427
Cdd:cd05592  83 LM-FHIQQSGRF-------DEdrarfyGAEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKE---NIYGEN 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  428 QGAKF---PiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQV--ERGYRmpcPQGCPESLHEL 502
Cdd:cd05592 152 KASTFcgtP-DYIAPEILKGQKYNQSVDWWSFGVLLYEMLI-GQSPFHGEDEDELFWSIcnDTPHY---PRWLTKEAASC 226
                       250
                ....*....|..
gi 6678617  503 MNLCWKKDPDER 514
Cdd:cd05592 227 LSLLLERNPEKR 238
PHA02988 PHA02988
hypothetical protein; Provisional
279-527 5.04e-12

hypothetical protein; Provisional


Pssm-ID: 165291 [Multi-domain]  Cd Length: 283  Bit Score: 66.69  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   279 VKLGQGCFgeVWMGTWNGTtKVAIKTLKP----GTMMPEAFLQEAQIMKKLRHDKLVPLYA----VVSEEP-IYIVTEFM 349
Cdd:PHA02988  28 IKENDQNS--IYKGIFNNK-EVIIRTFKKfhkgHKVLIDITENEIKNLRRIDSNNILKIYGfiidIVDDLPrLSLILEYC 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   350 SKGSLLDFL-KEGDgkyLKLPQLVDMAAQIADGMAYIER-MNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY-TA 426
Cdd:PHA02988 105 TRGYLREVLdKEKD---LSFKTKLDMAIDCCKGLYNLYKyTNKPYKNLTSVSFLVTENYKLKIICHGLEKILSSPPFkNV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   427 RQGAKFPIKWTAPeaaLYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQ-VERGYRMPCPQGCPESLHELMNL 505
Cdd:PHA02988 182 NFMVYFSYKMLND---IFSEYTIKDDIYSLGVVLWEIFT-GKIPFENLTTKEIYDLiINKNNSLKLPLDCPLEIKCIVEA 257
                        250       260
                 ....*....|....*....|..
gi 6678617   506 CWKKDPDERPTFEYIQSFLEDY 527
Cdd:PHA02988 258 CTSHDSIKRPNIKEILYNLSLY 279
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
281-514 5.25e-12

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 66.55  E-value: 5.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTL-------KPGTMMPeafLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSK 351
Cdd:cd05631   8 LGKGGFGEVCACQVRATGKMyACKKLekkrikkRKGEAMA---LNEKRILEKVNSRFVVSLaYAYETKDALCLVLTIMNG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 GSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEyTARqGAK 431
Cdd:cd05631  85 GDLKFHIYNMGNPGFDEQRAIFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGE-TVR-GRV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  432 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVtKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC---WK 508
Cdd:cd05631 163 GTVGYMAPEVINNEKYTFSPDWWGLGCLIYEMI-QGQSPFRKRKERVKREEVDRRVKEDQEEYSEKFSEDAKSICrmlLT 241

                ....*.
gi 6678617  509 KDPDER 514
Cdd:cd05631 242 KNPKER 247
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
308-424 5.40e-12

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 66.22  E-value: 5.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  308 GTMMPEAFLQEAQIMKKL-RHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFL------KEGDGKYLKLpqlvdmaaQIA 379
Cdd:cd14093  48 AEELREATRREIEILRQVsGHPNIIELHDVFeSPTFIFLVFELCRKGELFDYLtevvtlSEKKTRRIMR--------QLF 119
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6678617  380 DGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY 424
Cdd:cd14093 120 EAVEFLHSLNIVHRDLKPENILLDDNLNVKISDFGFATRLDEGEK 164
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
318-459 5.83e-12

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 66.12  E-value: 5.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  318 EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGdgkyLKLPQLvDMAAQIAD---GMAYIERMNYIHR 393
Cdd:cd14185  48 EILIIKSLSHPNIVKLFEVYeTEKEIYLILEYVRGGDLFDAIIES----VKFTEH-DAALMIIDlceALVYIHSKHIVHR 122
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  394 DLRAANILVGEN----LICKIADFGLARLIEDNEYTArqgAKFPiKWTAPEAALYGRFTIKSDVWSFGIL 459
Cdd:cd14185 123 DLKPENLLVQHNpdksTTLKLADFGLAKYVTGPIFTV---CGTP-TYVAPEILSEKGYGLEVDMWAAGVI 188
SH2_Tec_Txk cd10398
Src homology 2 (SH2) domain found in Tec protein, Txk; A member of the Tec protein tyrosine ...
155-249 6.45e-12

Src homology 2 (SH2) domain found in Tec protein, Txk; A member of the Tec protein tyrosine kinase Txk is expressed in thymus, spleen, lymph node, T lymphocytes, NK cells, mast cell lines, and myeloid cell line. Txk plays a role in TCR signal transduction, T cell development, and selection which is analogous to the function of Itk. Txk has been shown to interact with IFN-gamma. Unlike most of the Tec family members Txk lacks a PH domain. Instead Txk has a unique region containing a palmitoylated cysteine string which has a similar membrane tethering function as the PH domain. Txk also has a zinc-binding motif, a SH3 domain, a SH2 domain, and a protein kinase catalytic domain. The TH domain consists of a Zn2+-binding Btk motif and a proline-rich region. The Btk motif is found in Tec kinases, Ras GAP, and IGBP and crucial to the function of the PH domain. It is not present in Txk which is not surprising since it lacks a PH domain. The type 1 splice form of the Drosophila homolog also lacks both the PH domain and the Btk motif. The proline-rich regions are highly conserved for the most part with the exception of Bmx whose residues surrounding the PXXP motif are not conserved (TH-like) and Btk29A which is entirely unique with large numbers of glycine residues (TH-extended). Tec family members all lack a C-terminal tyrosine having an autoinhibitory function in its phosphorylated state. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198261  Cd Length: 106  Bit Score: 62.27  E-value: 6.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLNPGNQrGIFLVRESeTTKGAYSLSI--RDWDEVRGDnVKHYKIRKLDNGGYYITTRAQFDTLQ 232
Cdd:cd10398   7 EWYHKNITRNQAERLLRQESKE-GAFIVRDS-RHLGSYTISVftRARRSTEAS-IKHYQIKKNDSGQWYVAERHLFQSIP 83
                        90
                ....*....|....*..
gi 6678617  233 KLVKHYTEHADGLCHKL 249
Cdd:cd10398  84 ELIQYHQHNAAGLMSRL 100
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
280-516 6.89e-12

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 67.16  E-value: 6.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   280 KLGQGCFGEVWMGTWNGTTKV-AIKTLKpGTMMPEAFLQ---EAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSL 354
Cdd:PLN00034  81 RIGSGAGGTVYKVIHRPTGRLyALKVIY-GNHEDTVRRQicrEIEILRDVNHPNVVKCHDMFDHNgEIQVLLEFMDGGSL 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   355 ldflkegDGKYL-KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIED--NEYTARQGAk 431
Cdd:PLN00034 160 -------EGTHIaDEQFLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQtmDPCNSSVGT- 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   432 fpIKWTAPE-------AALYGRFTikSDVWSFG--ILQTELvtkGRVPYPgmvnreVLEQVERGYRMpC-------PQGC 495
Cdd:PLN00034 232 --IAYMSPErintdlnHGAYDGYA--GDIWSLGvsILEFYL---GRFPFG------VGRQGDWASLM-CaicmsqpPEAP 297
                        250       260
                 ....*....|....*....|....
gi 6678617   496 PESLHELMN---LCWKKDPDERPT 516
Cdd:PLN00034 298 ATASREFRHfisCCLQREPAKRWS 321
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
281-516 7.82e-12

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 65.99  E-value: 7.82e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM------GTWNGTTKVAIKTLKPGTMMpeAFLQEAQIMKKLRHDKLVPLYAVVSEE---PIYIVTEFMSK 351
Cdd:cd14049  14 LGKGGYGKVYKvrnkldGQYYAIKKILIKKVTKRDCM--KVLREVKVLAGLQHPNIVGYHTAWMEHvqlMLYIQMQLCEL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  352 gSLLDFL--------KEGDGKYLKLPQLVDMAA----QIADGMAYIERMNYIHRDLRAANILV-GENLICKIADFGLA-- 416
Cdd:cd14049  92 -SLWDWIvernkrpcEEEFKSAPYTPVDVDVTTkilqQLLEGVTYIHSMGIVHRDLKPRNIFLhGSDIHVRIGDFGLAcp 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  417 -RLIEDNEYTARQGAKFPIK--------WTAPEAALYGRFTIKSDVWSFGILQTELVtkgrVPYPGMVNR-EVLEQVERG 486
Cdd:cd14049 171 dILQDGNDSTTMSRLNGLTHtsgvgtclYAAPEQLEGSHYDFKSDMYSIGVILLELF----QPFGTEMERaEVLTQLRNG 246
                       250       260       270
                ....*....|....*....|....*....|..
gi 6678617  487 yRMPCP--QGCPESLHELMNLCwKKDPDERPT 516
Cdd:cd14049 247 -QIPKSlcKRWPVQAKYIKLLT-STEPSERPS 276
SH2_C-SH2_PLC_gamma_like cd09932
C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma; Phospholipase C gamma is a ...
154-241 8.10e-12

C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma; Phospholipase C gamma is a signaling molecule that is recruited to the C-terminal tail of the receptor upon autophosphorylation of a highly conserved tyrosine. PLCgamma is composed of a Pleckstrin homology (PH) domain followed by an elongation factor (EF) domain, 2 catalytic regions of PLC domains that flank 2 tandem SH2 domains (N-SH2, C-SH2), and ending with a SH3 domain and C2 domain. N-SH2 SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. Both N-SH2 and C-SH2 have a very similar binding affinity to pY. But in growth factor stimulated cells these domains bind to different target proteins. N-SH2 binds to pY containing sites in the C-terminal tails of tyrosine kinases and other receptors. Recently it has been shown that this interaction is mediated by phosphorylation-independent interactions between a secondary binding site found exclusively on the N-SH2 domain and a region of the FGFR1 tyrosine kinase domain. This secondary site on the SH2 cooperates with the canonical pY site to regulate selectivity in mediating a specific cellular process. C-SH2 binds to an intramolecular site on PLCgamma itself which allows it to hydrolyze phosphatidylinositol-4,5-bisphosphate into diacylglycerol and inositol triphosphate. These then activate protein kinase C and release calcium. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198186  Cd Length: 104  Bit Score: 61.90  E-value: 8.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  154 EEWYFGKMGRKDAERLLlNPGNQRGIFLVRESETTKGAYSLSIRdwdeVRGDnVKHYKIRKldNGGYYITTRAQFDTLQK 233
Cdd:cd09932   4 KEWFHANLTREQAEEML-MRVPRDGAFLVRPSETDPNSFAISFR----AEGK-IKHCRIKQ--EGRLFVIGTSQFESLVE 75

                ....*...
gi 6678617  234 LVKHYTEH 241
Cdd:cd09932  76 LVSYYEKH 83
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
329-518 8.22e-12

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 65.73  E-value: 8.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  329 KLVPLYAVVSEepIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLI- 407
Cdd:cd14197  73 NLHEVYETASE--MILVLEYAAGGEIFNQCVADREEAFKEKDVKRLMKQILEGVSFLHNNNVVHLDLKPQNILLTSESPl 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  408 --CKIADFGLARLIEDNEyTARQGAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREV---LEQ 482
Cdd:cd14197 151 gdIKIVDFGLSRILKNSE-ELREIMGTP-EYVAPEILSYEPISTATDMWSIGVLAYVMLT-GISPFLGDDKQETflnISQ 227
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6678617  483 VERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFE 518
Cdd:cd14197 228 MNVSYSEEEFEHLSESAIDFIKTLLIKKPENRATAE 263
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
281-514 8.35e-12

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 66.57  E-value: 8.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPE----AFLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd05595   3 LGKGTFGKVILVREKATGRYyAMKILRKEVIIAKdevaHTVTESRVLQNTRHPFLTALkYAFQTHDRLCFVMEYANGGEL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 ldFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPi 434
Cdd:cd05595  83 --FFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGITDGATMKTFCGTP- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  435 KWTAPEAAL---YGRFTiksDVWSFGILQTELVTkGRVPYPGMVNREVLEQV-ERGYRMPcPQGCPESLHELMNLCwKKD 510
Cdd:cd05595 160 EYLAPEVLEdndYGRAV---DWWGLGVVMYEMMC-GRLPFYNQDHERLFELIlMEEIRFP-RTLSPEAKSLLAGLL-KKD 233

                ....
gi 6678617  511 PDER 514
Cdd:cd05595 234 PKQR 237
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
266-483 9.33e-12

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 66.03  E-value: 9.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIPRESL-RLEV--KLGQGCFGEVWMGtWNGTT--KVAIKTLKPgtMMPEAFLQEAQIMKKLR-HDKLVPLYAVV-- 337
Cdd:cd14132   8 ENLNVEWGSQdDYEIirKIGRGKYSEVFEG-INIGNneKVVIKVLKP--VKKKKIKREIKILQNLRgGPNIVKLLDVVkd 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  338 -SEEPIYIVTEFMSKgslLDFlkegdgKYLkLPQLVDMAA-----QIADGMAYIERMNYIHRDLRAANILVG-ENLICKI 410
Cdd:cd14132  85 pQSKTPSLIFEYVNN---TDF------KTL-YPTLTDYDIryymyELLKALDYCHSKGIMHRDVKPHNIMIDhEKRKLRL 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  411 ADFGLARL-IEDNEYTARQGAKFpikWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV 483
Cdd:cd14132 155 IDWGLAEFyHPGQEYNVRVASRY---YKGPELLVdYQYYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVKI 226
SH3_Tec cd11905
Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma); Tec is a ...
93-145 1.10e-11

Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma); Tec is a cytoplasmic (or nonreceptor) tyr kinase containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. It is more widely-expressed than other Tec subfamily kinases. Tec is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Tec is a key component of T-cell receptor (TCR) signaling, and is important in TCR-stimulated proliferation, IL-2 production and phospholipase C-gamma1 activation. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212838 [Multi-domain]  Cd Length: 56  Bit Score: 59.83  E-value: 1.10e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiATGKSGYIPSNYV 145
Cdd:cd11905   2 IVVAMYDFQPTEPHDLRLETGEEYVILEKNDVHWWKARD-KYGKEGYIPSNYV 53
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
256-471 1.20e-11

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 66.57  E-value: 1.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  256 VKPQTQgLAKDAwEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEA----FLQEAQIMKKLRHDKL 330
Cdd:cd05624  57 AKPFTQ-LVKEM-QLHRDDFEIIKVIGRGAFGEVAVVKMKNTERIyAMKILNKWEMLKRAetacFREERNVLVNGDCQWI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  331 VPL-YAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKylkLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGEN 405
Cdd:cd05624 135 TTLhYAFQDENYLYLVMDYYVGGDLLTLLSKFEDK---LPE--DMArfyiGEMVLAIHSIHQLHYVHRDIKPDNVLLDMN 209
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6678617  406 LICKIADFG-LARLIEDNEYTARQGAKFPiKWTAPE--AAL---YGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd05624 210 GHIRLADFGsCLKMNDDGTVQSSVAVGTP-DYISPEilQAMedgMGKYGPECDWWSLGVCMYEMLY-GETPF 279
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
317-471 1.30e-11

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 65.78  E-value: 1.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLR-HDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKegdgkylKLPQLVDMAA-----QIADGMAYIERMN 389
Cdd:cd14092  47 REVQLLRLCQgHPNIVKLHEVFQDElHTYLVMELLRGGELLERIR-------KKKRFTESEAsrimrQLVSAVSFMHSKG 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  390 YIHRDLRAANILV---GENLICKIADFGLARLIEDNEytARQGAKFPIKWTAPE----AALYGRFTIKSDVWSFG-ILQT 461
Cdd:cd14092 120 VVHRDLKPENLLFtdeDDDAEIKIVDFGFARLKPENQ--PLKTPCFTLPYAAPEvlkqALSTQGYDESCDLWSLGvILYT 197
                       170
                ....*....|
gi 6678617  462 ELvtKGRVPY 471
Cdd:cd14092 198 ML--SGQVPF 205
SH2_SHB_SHD_SHE_SHF_like cd09945
Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, ...
156-241 1.34e-11

Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF); SHB, SHD, SHE, and SHF are SH2 domain-containing proteins that play various roles throughout the cell. SHB functions in generating signaling compounds in response to tyrosine kinase activation. SHB contains proline-rich motifs, a phosphotyrosine binding (PTB) domain, tyrosine phosphorylation sites, and a SH2 domain. SHB mediates certain aspects of platelet-derived growth factor (PDGF) receptor-, fibroblast growth factor (FGF) receptor-, neural growth factor (NGF) receptor TRKA-, T cell receptor-, interleukin-2 (IL-2) receptor- and focal adhesion kinase- (FAK) signaling. SRC-like FYN-Related Kinase FRK/RAK (also named BSK/IYK or GTK) and SHB regulate apoptosis, proliferation and differentiation. SHB promotes apoptosis and is also required for proper mitogenicity, spreading and tubular morphogenesis in endothelial cells. SHB also plays a role in preventing early cavitation of embryoid bodies and reduces differentiation to cells expressing albumin, amylase, insulin and glucagon. SHB is a multifunctional protein that has difference responses in different cells under various conditions. SHE is expressed in heart, lung, brain, and skeletal muscle, while expression of SHD is restricted to the brain. SHF is mainly expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine, and colon. SHD may be a physiological substrate of c-Abl and may function as an adapter protein in the central nervous system. It is also thought to be involved in apoptotic regulation. SHD contains five YXXP motifs, a substrate sequence preferred by Abl tyrosine kinases, in addition to a poly-proline rich region and a C-terminal SH2 domain. SHE contains two pTry protein binding domains, protein interaction domain (PID) and a SH2 domain, followed by a glycine-proline rich region, all of which are N-terminal to the phosphotyrosine binding (PTB) domain. SHF contains four putative tyrosine phosphorylation sites and an SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198198  Cd Length: 98  Bit Score: 60.90  E-value: 1.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLlnPGNQRGIFLVRESETTKGAYSLSIRdwdEVRGdnVKHYKIRKLDNGGYYI-TTRAQFDTLQKL 234
Cdd:cd09945   3 WYHGAITRIEAESLL--RPCKEGSYLVRNSESTKQDYSLSLK---SAKG--FMHMRIQRNETGQYILgQFSRPFETIPEM 75

                ....*..
gi 6678617  235 VKHYTEH 241
Cdd:cd09945  76 IRHYCLN 82
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
280-516 1.55e-11

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 67.07  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    280 KLGQGCFGEVWMGTWNGTTK------VAIKTLKpgTMMPEAFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMS 350
Cdd:PTZ00266   20 KIGNGRFGEVFLVKHKRTQEffcwkaISYRGLK--EREKSQLVIEVNVMRELKHKNIVRYidrFLNKANQKLYILMEFCD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    351 KGSLLDFLKEGDGKYLKLPQ--LVDMAAQIADGMAYIERMN-------YIHRDLRAANILV-------------GENL-- 406
Cdd:PTZ00266   98 AGDLSRNIQKCYKMFGKIEEhaIVDITRQLLHALAYCHNLKdgpngerVLHRDLKPQNIFLstgirhigkitaqANNLng 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617    407 --ICKIADFGLARLIeDNEYTARQGAKFPIKWTaPEAALY--GRFTIKSDVWSFGILQTELVTkGRVPYPGMVN-REVLE 481
Cdd:PTZ00266  178 rpIAKIGDFGLSKNI-GIESMAHSCVGTPYYWS-PELLLHetKSYDDKSDMWALGCIIYELCS-GKTPFHKANNfSQLIS 254
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 6678617    482 QVERGYRMPCpQGCPESLHELMNLCWKKDPDERPT 516
Cdd:PTZ00266  255 ELKRGPDLPI-KGKSKELNILIKNLLNLSAKERPS 288
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
281-464 1.62e-11

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 66.05  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   281 LGQGCFGEVWMGTWNGT-TKVAIKT-LKPGTMMpeaflqEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 358
Cdd:PHA03209  74 LTPGSEGRVFVATKPGQpDPVVLKIgQKGTTLI------EAMLLQNVNHPSVIRMKDTLVSGAITCMVLPHYSSDLYTYL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   359 KEGDGKyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-GENLICkIADFGLAR--LIEDNEYtarqGAKFPIK 435
Cdd:PHA03209 148 TKRSRP-LPIDQALIIEKQILEGLRYLHAQRIIHRDVKTENIFInDVDQVC-IGDLGAAQfpVVAPAFL----GLAGTVE 221
                        170       180
                 ....*....|....*....|....*....
gi 6678617   436 WTAPEAALYGRFTIKSDVWSFGILQTELV 464
Cdd:PHA03209 222 TNAPEVLARDKYNSKADIWSAGIVLFEML 250
SH3_Eve1_4 cd11817
Fourth Src homology 3 domain of ADAM-binding protein Eve-1; Eve-1, also called SH3 ...
95-144 1.75e-11

Fourth Src homology 3 domain of ADAM-binding protein Eve-1; Eve-1, also called SH3 domain-containing protein 19 (SH3D19) or EEN-binding protein (EBP), exists in multiple alternatively spliced isoforms. The longest isoform contains five SH3 domain in the C-terminal region and seven proline-rich motifs in the N-terminal region. It is abundantly expressed in skeletal muscle and heart, and may be involved in regulating the activity of ADAMs (A disintegrin and metalloproteases). Eve-1 interacts with EEN, an endophilin involved in endocytosis and may be the target of the MLL-EEN fusion protein that is implicated in leukemogenesis. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212751 [Multi-domain]  Cd Length: 50  Bit Score: 59.03  E-value: 1.75e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARsiATGKSGYIPSNY 144
Cdd:cd11817   3 VALYDFTGETEEDLSFQRGDRILVTEHLDAEWSRGR--LNGREGIFPRAF 50
SH2_Nck1 cd10408
Src homology 2 (SH2) domain found in Nck; Nck proteins are adaptors that modulate actin ...
155-238 1.76e-11

Src homology 2 (SH2) domain found in Nck; Nck proteins are adaptors that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates. There are two members known in this family: Nck1 (Nckalpha) and Nck2 (Nckbeta and Growth factor receptor-bound protein 4 (Grb4)). They are characterized by having 3 SH3 domains and a C-terminal SH2 domain. Nck1 and Nck2 have overlapping functions as determined by gene knockouts. Both bind receptor tyrosine kinases and other tyrosine-phosphorylated proteins through their SH2 domains. In addition they also bind distinct targets. Neuronal signaling proteins: EphrinB1, EphrinB2, and Disabled-1 (Dab-1) all bind to Nck-2 exclusively. And in the case of PDGFR, Tyr(P)751 binds to Nck1 while Tyr(P)1009 binds to Nck2. Nck1 and Nck2 have a role in the infection process of enteropathogenic Escherichia coli (EPEC). Their SH3 domains are involved in recruiting and activating the N-WASP/Arp2/3 complex inducing actin polymerization resulting in the production of pedestals, dynamic bacteria-presenting protrusions of the plasma membrane. A similar thing occurs in the vaccinia virus where motile plasma membrane projections are formed beneath the virus. Recently it has been shown that the SH2 domains of both Nck1 and Nck2 bind the G-protein coupled receptor kinase-interacting protein 1 (GIT1) in a phosphorylation-dependent manner. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198271  Cd Length: 97  Bit Score: 60.81  E-value: 1.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  155 EWYFGKMGRKDAERLLLNPGNQrGIFLVRESETTKGAYSLSIRdwdeVRGDNvKHYKIRKLDNggYYITTRAQFDTLQKL 234
Cdd:cd10408   2 PWYYGKVTRHQAEMALNERGNE-GDFLIRDSESSPNDFSVSLK----AQGKN-KHFKVQLKEC--VYCIGQRKFSSMEEL 73

                ....
gi 6678617  235 VKHY 238
Cdd:cd10408  74 VEHY 77
STKc_MRCK_alpha cd05623
Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 ...
272-471 1.83e-11

Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270773 [Multi-domain]  Cd Length: 409  Bit Score: 66.19  E-value: 1.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIV 345
Cdd:cd05623  71 KEDFEILKVIGRGAFGEVAVVKLKNADKVfAMKILNKWEMLKRAetacFREERDVLVNGDSQWITTLhYAFQDDNNLYLV 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGDGKylkLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG-LARLIE 420
Cdd:cd05623 151 MDYYVGGDLLTLLSKFEDR---LPE--DMArfylAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGsCLKLME 225
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617  421 DNEYTARQGAKFPiKWTAPE--AAL---YGRFTIKSDVWSFGILQTELVTkGRVPY 471
Cdd:cd05623 226 DGTVQSSVAVGTP-DYISPEilQAMedgKGKYGPECDWWSLGVCMYEMLY-GETPF 279
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
275-514 1.84e-11

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 65.07  E-value: 1.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  275 LRLEVKLGQGCFGEVWMGTWNGTT-KVA---IKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY-----AVVSEEPIYIV 345
Cdd:cd14030  27 LKFDIEIGRGSFKTVYKGLDTETTvEVAwceLQDRKLSKSERQRFKEEAGMLKGLQHPNIVRFYdswesTVKGKKCIVLV 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEgdGKYLKLPQLVDMAAQIADGMAYIERMN--YIHRDLRAANILV-GENLICKIADFGLARLIEDN 422
Cdd:cd14030 107 TELMTSGTLKTYLKR--FKVMKIKVLRSWCRQILKGLQFLHTRTppIIHRDLKCDNIFItGPTGSVKIGDLGLATLKRAS 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  423 EYTARQGAKfpiKWTAPEaALYGRFTIKSDVWSFGILQTELVTKgRVPY-----PGMVNREVLEQVERGY--RMPCPQgc 495
Cdd:cd14030 185 FAKSVIGTP---EFMAPE-MYEEKYDESVDVYAFGMCMLEMATS-EYPYsecqnAAQIYRRVTSGVKPASfdKVAIPE-- 257
                       250
                ....*....|....*....
gi 6678617  496 pesLHELMNLCWKKDPDER 514
Cdd:cd14030 258 ---VKEIIEGCIRQNKDER 273
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
257-472 1.93e-11

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 65.22  E-value: 1.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   257 KPQTQGlakdaWEIprESLRLEVKLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTMMP----EAFLQEAQIMKKLRHDKLV 331
Cdd:PTZ00263   9 KPDTSS-----WKL--SDFEMGETLGTGSFGRVRIAKHKGTGEyYAIKCLKKREILKmkqvQHVAQEKSILMELSHPFIV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617   332 PLY-AVVSEEPIYIVTEFMSKGSLLDFLKEGdGKYlklPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENL 406
Cdd:PTZ00263  82 NMMcSFQDENRVYFLLEFVVGGELFTHLRKA-GRF---PN--DVAkfyhAELVLAFEYLHSKDIIYRDLKPENLLLDNKG 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678617   407 ICKIADFGLARLIEDNEYTArqgAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVtkgrVPYP 472
Cdd:PTZ00263 156 HVKVTDFGFAKKVPDRTFTL---CGTP-EYLAPEVIQSKGHGKAVDWWTMGVLLYEFI----AGYP 213
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
313-486 2.21e-11

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 64.07  E-value: 2.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  313 EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYiVTEFMSKGS----LLDFLKEGDGKYLKlPQLVDMAAQIADGMAYIERM 388
Cdd:cd14109  41 PFLMREVDIHNSLDHPNIVQMHDAYDDEKLA-VTVIDNLAStielVRDNLLPGKDYYTE-RQVAVFVRQLLLALKHMHDL 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  389 NYIHRDLRAANILVGENLICkIADFGLARLIE-DNEYTARQGAKfpiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkG 467
Cdd:cd14109 119 GIAHLDLRPEDILLQDDKLK-LADFGQSRRLLrGKLTTLIYGSP---EFVSPEIVNSYPVTLATDMWSVGVLTYVLLG-G 193
                       170
                ....*....|....*....
gi 6678617  468 RVPYPGMVNREVLEQVERG 486
Cdd:cd14109 194 ISPFLGDNDRETLTNVRSG 212
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
266-473 2.30e-11

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 64.86  E-value: 2.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEipreslRLEvKLGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHD-KLVPLYAV--VS 338
Cdd:cd07837   1 DAYE------KLE-KIGEGTYGKVYKARDKNTGKlVALKKTRlemEEEGVPSTALREVSLLQMLSQSiYIVRLLDVehVE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  339 EEP---IYIVTEFMSKG--SLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLICKIAD 412
Cdd:cd07837  74 ENGkplLYLVFEYLDTDlkKFIDSYGRGPHNPLPAKTIQSFMYQLCKGVAHCHSHGVMHRDLKPQNLLVDkQKGLLKIAD 153
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678617  413 FGLARL--IEDNEYTARqgaKFPIKWTAPEAALYG-RFTIKSDVWSFGILQTELVTKGRVpYPG 473
Cdd:cd07837 154 LGLGRAftIPIKSYTHE---IVTLWYRAPEVLLGStHYSTPVDMWSVGCIFAEMSRKQPL-FPG 213
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
283-514 2.45e-11

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 64.42  E-value: 2.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  283 QGCFGEVWMGTWNGTTK-VAIKTLKPGTMMPE-----AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 355
Cdd:cd05611   6 KGAFGSVYLAKKRSTGDyFAIKVLKKSDMIAKnqvtnVKAERAIMMIQGESPYVAKLYYSFqSKDYLYLVMEYLNGGDCA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGkyLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNeytaRQGAKF--- 432
Cdd:cd05611  86 SLIKTLGG--LPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGLSRNGLEK----RHNKKFvgt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGyRMPCP----QGCPESLHELMNLCWK 508
Cdd:cd05611 160 P-DYLAPETILGVGDDKMSDWWSLGCVIFEFLF-GYPPFHAETPDAVFDNILSR-RINWPeevkEFCSPEAVDLINRLLC 236

                ....*.
gi 6678617  509 KDPDER 514
Cdd:cd05611 237 MDPAKR 242
SH2_DAPP1_BAM32_like cd10355
Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( ...
149-238 2.50e-11

Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins; DAPP1/Bam32 contains a putative myristoylation site at its N-terminus, followed by a SH2 domain, and a pleckstrin homology (PH) domain at its C-terminus. DAPP1 could potentially be recruited to the cell membrane by any of these domains. Its putative myristoylation site could facilitate the interaction of DAPP1 with the lipid bilayer. Its SH2 domain may also interact with phosphotyrosine residues on membrane-associated proteins such as activated tyrosine kinase receptors. And finally its PH domain exhibits a high-affinity interaction with the PtdIns(3,4,5)P(3) PtdIns(3,4)P(2) second messengers produced at the cell membrane following the activation of PI 3-kinases. DAPP1 is thought to interact with both tyrosine phosphorylated proteins and 3-phosphoinositides and therefore may play a role in regulating the location and/or activity of such proteins(s) in response to agonists that elevate PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2). This protein is likely to play an important role in triggering signal transduction pathways that lie downstream from receptor tyrosine kinases and PI 3-kinase. It is likely that DAPP1 functions as an adaptor to recruit other proteins to the plasma membrane in response to extracellular signals. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198218  Cd Length: 92  Bit Score: 60.18  E-value: 2.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  149 DSIQAEEWYFGKMGRKDAERLLLNPGnQRGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKldNGGYYITTRAQF 228
Cdd:cd10355   1 ELLQSLGWYHGNLTRHAAEALLLSNG-VDGSYLLRNSNEGTGLFSLSVRA-----KDSVKHFHVEY--TGYSFKFGFNEF 72
                        90
                ....*....|
gi 6678617  229 DTLQKLVKHY 238
Cdd:cd10355  73 SSLQDFVKHF 82
STKc_DMPK_like cd05597
Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; ...
281-463 2.52e-11

Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is composed of DMPK and DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK). DMPK is expressed in skeletal and cardiac muscles, and in central nervous tissues. The functional role of DMPK is not fully understood. It may play a role in the signal transduction and homeostasis of calcium. The DMPK gene is implicated in myotonic dystrophy 1 (DM1), an inherited multisystemic disorder with symptoms that include muscle hyperexcitability, progressive muscle weakness and wasting, cataract development, testicular atrophy, and cardiac conduction defects. The genetic basis for DM1 is the mutational expansion of a CTG repeat in the 3'-UTR of DMPK. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270748 [Multi-domain]  Cd Length: 331  Bit Score: 65.06  E-value: 2.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMMPEA----FLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFMSKGSL 354
Cdd:cd05597   9 IGRGAFGEVAVVKLKSTEKVyAMKILNKWEMLKRAetacFREERDVLVNGDRRWITKLhYAFQDENYLYLVMDYYCGGDL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  355 LDFL-KEGDgkylKLPQlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG-LARLIEDNEYTARQ 428
Cdd:cd05597  89 LTLLsKFED----RLPE--EMArfylAEMVLAIDSIHQLGYVHRDIKPDNVLLDRNGHIRLADFGsCLKLREDGTVQSSV 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6678617  429 GAKFPiKWTAPE--AAL---YGRFTIKSDVWSFGILQTEL 463
Cdd:cd05597 163 AVGTP-DYISPEilQAMedgKGRYGPECDWWSLGVCMYEM 201
SH3_Brk cd11847
Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called ...
93-145 2.68e-11

Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6; Brk is a cytoplasmic (or non-receptor) PTK with limited homology to Src kinases. It has been found to be overexpressed in a majority of breast tumors. It plays roles in normal cell differentiation, proliferation, survival, migration, and cell cycle progression. Brk substrates include RNA-binding proteins (SLM-1/2, Sam68), transcription factors (STAT3/5), and signaling molecules (Akt, paxillin, IRS-4). Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). However, Brk lacks the N-terminal myristoylation site. The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212781 [Multi-domain]  Cd Length: 58  Bit Score: 58.72  E-value: 2.68e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNtEGDWWEARSI-----ATGKsGYIPSNYV 145
Cdd:cd11847   1 IYKALWDFKARGDEELSFQAGDQFRIAER-SGDWWTALKLdraggVVAQ-GFVPNNYL 56
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
280-465 2.70e-11

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 64.91  E-value: 2.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMgTWN--GTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH--------DKLVPLY---AVVSEEPIYI-- 344
Cdd:cd14136  17 KLGWGHFSTVWL-CWDlqNKRFVALKVVKSAQHYTEAALDEIKLLKCVREadpkdpgrEHVVQLLddfKHTGPNGTHVcm 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  345 VTEFMSKgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYI-ERMNYIHRDLRAANILVGE-NLICKIADFGLARLIeDN 422
Cdd:cd14136  96 VFEVLGP-NLLKLIKRYNYRGIPLPLVKKIARQVLQGLDYLhTKCGIIHTDIKPENVLLCIsKIEVKIADLGNACWT-DK 173
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6678617  423 EYTA----RQgakfpikWTAPEAALYGRFTIKSDVWSFGILQTELVT 465
Cdd:cd14136 174 HFTEdiqtRQ-------YRSPEVILGAGYGTPADIWSTACMAFELAT 213
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
281-414 2.96e-11

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 61.30  E-value: 2.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEV-WMGTWNGTTKVAIKTLK-PGTMMPEAFLQEAQIMKKLR-HDKLVPLYAVVSE--EPIYIVTEFMSKGSLL 355
Cdd:cd13968   1 MGEGASAKVfWAEGECTTIGVAVKIGDdVNNEEGEDLESEMDILRRLKgLELNIPKVLVTEDvdGPNILLMELVKGGTLI 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  356 DFLKEGdgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG 414
Cdd:cd13968  81 AYTQEE---ELDEKDVESIMYQLAECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
266-520 3.32e-11

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 64.24  E-value: 3.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  266 DAWEIpreslrLEVkLGQGCFGEVWMGTwNGT--TKVAIKTLKPGTMMPEAFLQEAQIMKKL-RHDKLVPLYAVVSEE-- 340
Cdd:cd06639  22 DTWDI------IET-IGKGTYGKVYKVT-NKKdgSLAAVKILDPISDVDEEIEAEYNILRSLpNHPNVVKFYGMFYKAdq 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  341 ----PIYIVTEFMSKGSLLDFLKE--GDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFG 414
Cdd:cd06639  94 yvggQLWLVLELCNGGSVTELVKGllKCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFG 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  415 LARLIEDNEYTARQGAKFPIkWTAPEAALYGR-----FTIKSDVWSFGILQTELvTKGRVPYPGMVNREVLEQVERGyrm 489
Cdd:cd06639 174 VSAQLTSARLRRNTSVGTPF-WMAPEVIACEQqydysYDARCDVWSLGITAIEL-ADGDPPLFDMHPVKALFKIPRN--- 248
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6678617  490 PCP------QGCpESLHELMNLCWKKDPDERPTFEYI 520
Cdd:cd06639 249 PPPtllnpeKWC-RGFSHFISQCLIKDFEKRPSVTHL 284
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
281-522 4.18e-11

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 63.45  E-value: 4.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGT-WNGTTKVAIK-----------TLKPGTMMPeaflQEAQIMKKL---------------RHDKLVpl 333
Cdd:cd14100   8 LGSGGFGSVYSGIrVADGAPVAIKhvekdrvsewgELPNGTRVP----MEIVLLKKVgsgfrgvirlldwfeRPDSFV-- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  334 yaVVSEEPIYIvtefmskGSLLDFLKEGDGkylkLPQlvDMAA----QIADGMAYIERMNYIHRDLRAANILV----GEn 405
Cdd:cd14100  82 --LVLERPEPV-------QDLFDFITERGA----LPE--ELARsffrQVLEAVRHCHNCGVLHRDIKDENILIdlntGE- 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  406 liCKIADFGLARLIEDNEYTARQGAKFpikWTAPEAALYGRFTIKS-DVWSFGILQTELVTkGRVPYpgmvnrEVLEQVE 484
Cdd:cd14100 146 --LKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRFHRYHGRSaAVWSLGILLYDMVC-GDIPF------EHDEEII 213
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6678617  485 RGYRMPCPQGCPESLHeLMNLCWKKDPDERPTFEYIQS 522
Cdd:cd14100 214 RGQVFFRQRVSSECQH-LIKWCLALRPSDRPSFEDIQN 250
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
281-473 4.91e-11

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 63.86  E-value: 4.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTK-VAIKTLK---PGTMMPEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKgSLL 355
Cdd:cd07848   9 VGEGAYGVVLKCRHKETKEiVAIKKFKdseENEEVKETTLRELKMLRTLKQENIVELKeAFRRRGKLYLVFEYVEK-NML 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLKEGDGKylKLPQLV-DMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE---DNEYTARQGAK 431
Cdd:cd07848  88 ELLEEMPNG--VPPEKVrSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSegsNANYTEYVATR 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6678617  432 FpikWTAPEAALYGRFTIKSDVWSFGILQTELvTKGRVPYPG 473
Cdd:cd07848 166 W---YRSPELLLGAPYGKAVDMWSVGCILGEL-SDGQPLFPG 203
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
283-516 4.93e-11

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 63.10  E-value: 4.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  283 QGCFGEVWMGTWNGTTK------VAIKTLKPGtmmpeaflqEAQIMKKLRHDKLVPLY-AVVSEEPIYIVTEFMSKGSLL 355
Cdd:cd13995  14 RGAFGKVYLAQDTKTKKrmacklIPVEQFKPS---------DVEIQACFRHENIAELYgALLWEETVHLFMEAGEGGSVL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  356 DFLkEGDGKYLKLpQLVDMAAQIADGMAYIERMNYIHRDLRAANIlVGENLICKIADFGLARLIEDNEYTAR--QGAKFp 433
Cdd:cd13995  85 EKL-ESCGPMREF-EIIWVTKHVLKGLDFLHSKNIIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVYVPKdlRGTEI- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  434 ikWTAPEAALYGRFTIKSDVWSFGILQTELVTKG--------RVPYPG---MVNREV--LEQVergyrmpcPQGCPESLH 500
Cdd:cd13995 161 --YMSPEVILCRGHNTKADIYSLGATIIHMQTGSppwvrrypRSAYPSylyIIHKQAppLEDI--------AQDCSPAMR 230
                       250
                ....*....|....*.
gi 6678617  501 ELMNLCWKKDPDERPT 516
Cdd:cd13995 231 ELLEAALERNPNHRSS 246
SH3_CRK_N cd11758
N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins; CRK adaptor ...
96-145 4.98e-11

N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins; CRK adaptor proteins consists of SH2 and SH3 domains, which bind tyrosine-phosphorylated peptides and proline-rich motifs, respectively. They function downstream of protein tyrosine kinases in many signaling pathways started by various extracellular signals, including growth and differentiation factors. Cellular CRK (c-CRK) contains a single SH2 domain, followed by N-terminal and C-terminal SH3 domains. It is involved in the regulation of many cellular processes including cell growth, motility, adhesion, and apoptosis. CRK has been implicated in the malignancy of various human cancers. The N-terminal SH3 domain of CRK binds a number of target proteins including DOCK180, C3G, SOS, and cABL. The CRK family includes two alternatively spliced protein forms, CRKI and CRKII, that are expressed by the CRK gene, and the CRK-like (CRKL) protein, which is expressed by a distinct gene (CRKL). SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212692 [Multi-domain]  Cd Length: 55  Bit Score: 58.14  E-value: 4.98e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617   96 ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiATGKSGYIPSNYV 145
Cdd:cd11758   5 ALFDFPGNDDEDLPFKKGEILTVIRKPEEQWWNARN-SEGKTGMIPVPYV 53
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
280-463 5.08e-11

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 63.83  E-value: 5.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMGTWNGTTK-VAIKTLKPGTM---MPEAFLQEAQIMKKLR---HDKLVPLYAVVS------EEPIYIVT 346
Cdd:cd07863   7 EIGVGAYGTVYKARDPHSGHfVALKSVRVQTNedgLPLSTVREVALLKRLEafdHPNIVRLMDVCAtsrtdrETKVTLVF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  347 EFMSKgSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLiedneYTA 426
Cdd:cd07863  87 EHVDQ-DLRTYLDKVPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGLARI-----YSC 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6678617  427 rQGAKFPIKWT----APEAALYGRFTIKSDVWSFGILQTEL 463
Cdd:cd07863 161 -QMALTPVVVTlwyrAPEVLLQSTYATPVDMWSVGCIFAEM 200
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
317-516 5.50e-11

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 63.60  E-value: 5.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  317 QEAQIMKKLRHDKLVPLYAVVSEEPI-YIVTEFMSKGSLLD------FLKEGDGKYLklpqlvdmAAQIADGMAYIERMN 389
Cdd:cd14086  49 REARICRLLKHPNIVRLHDSISEEGFhYLVFDLVTGGELFEdivareFYSEADASHC--------IQQILESVNHCHQNG 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  390 YIHRDLRAANILVG---ENLICKIADFGLARLIEDNEyTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFG-ILQTELVt 465
Cdd:cd14086 121 IVHRDLKPENLLLAsksKGAAVKLADFGLAIEVQGDQ-QAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGvILYILLV- 198
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  466 kGRVPYPGMVNREVLEQVERG-YRMPCPQG---CPESlHELMNLCWKKDPDERPT 516
Cdd:cd14086 199 -GYPPFWDEDQHRLYAQIKAGaYDYPSPEWdtvTPEA-KDLINQMLTVNPAKRIT 251
SH2_Nck2 cd10409
Src homology 2 (SH2) domain found in Nck; Nck proteins are adaptors that modulate actin ...
154-245 7.46e-11

Src homology 2 (SH2) domain found in Nck; Nck proteins are adaptors that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates. There are two members known in this family: Nck1 (Nckalpha) and Nck2 (Nckbeta and Growth factor receptor-bound protein 4 (Grb4)). They are characterized by having 3 SH3 domains and a C-terminal SH2 domain. Nck1 and Nck2 have overlapping functions as determined by gene knockouts. Both bind receptor tyrosine kinases and other tyrosine-phosphorylated proteins through their SH2 domains. In addition they also bind distinct targets. Neuronal signaling proteins: EphrinB1, EphrinB2, and Disabled-1 (Dab-1) all bind to Nck-2 exclusively. And in the case of PDGFR, Tyr(P)751 binds to Nck1 while Tyr(P)1009 binds to Nck2. Nck1 and Nck2 have a role in the infection process of enteropathogenic Escherichia coli (EPEC). Their SH3 domains are involved in recruiting and activating the N-WASP/Arp2/3 complex inducing actin polymerization resulting in the production of pedestals, dynamic bacteria-presenting protrusions of the plasma membrane. A similar thing occurs in the vaccinia virus where motile plasma membrane projections are formed beneath the virus. Recently it has been shown that the SH2 domains of both Nck1 and Nck2 bind the G-protein coupled receptor kinase-interacting protein 1 (GIT1) in a phosphorylation-dependent manner. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198272  Cd Length: 98  Bit Score: 58.89  E-value: 7.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  154 EEWYFGKMGRKDAERLLlnpgNQRGI---FLVRESETTKGAYSLSIRdwdeVRGDNvKHYKIrKLDNGGYYITTRaQFDT 230
Cdd:cd10409   1 KEWYYGNVTRHQAECAL----NERGVegdFLIRDSESSPSDFSVSLK----AVGKN-KHFKV-QLVDNVYCIGQR-RFNS 69
                        90       100
                ....*....|....*....|..
gi 6678617  231 LQKLVKHY-------TEHADGL 245
Cdd:cd10409  70 MDELVEHYkkapiftSEHGEKL 91
SH2_CRK_like cd09926
Src homology 2 domain found in cancer-related signaling adaptor protein CRK; SH2 domain in the ...
149-241 8.64e-11

Src homology 2 domain found in cancer-related signaling adaptor protein CRK; SH2 domain in the CRK proteins. CRKI (SH2-SH3) and CRKII (SH2-SH3-SH3) are splicing isoforms of the oncoprotein CRK. CRKs regulate transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. The SH2 domain of CRK associates with tyrosine-phosphorylated receptors or components of focal adhesions, such as p130Cas and paxillin. CRK transmits signals to small G proteins through effectors that bind its SH3 domain, such as C3G, the guanine-nucleotide exchange factor (GEF) for Rap1 and R-Ras, and DOCK180, the GEF for Rac6. The binding of p130Cas to the CRK-C3G complex activates Rap1, leading to regulation of cell adhesion, and activates R-Ras, leading to JNK-mediated activation of cell proliferation, whereas the binding of CRK DOCK180 induces Rac1-mediated activation of cellular migration. The activity of the different splicing isoforms varies greatly with CRKI displaying substantial transforming activity, CRKII less so, and phosphorylated CRKII with no biological activity whatsoever. CRKII has a linker region with a phosphorylated Tyr and an additional C-terminal SH3 domain. The phosphorylated Tyr creates a binding site for its SH2 domain which disrupts the association between CRK and its SH2 target proteins. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198180 [Multi-domain]  Cd Length: 106  Bit Score: 59.02  E-value: 8.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  149 DSIQAEEWYFGKMGRKDAERLLLnpGNQRGIFLVRESETTKGAYSLSIRDwdevrGDNVKHYKIRKLDNGGY----YITT 224
Cdd:cd09926   2 DSSDRSSWYFGPMSRQEAQELLQ--GQRHGVFLVRDSSTIPGDYVLSVSE-----NSRVSHYIINSLGQPAPnqsrYRIG 74
                        90
                ....*....|....*..
gi 6678617  225 RAQFDTLQKLVKHYTEH 241
Cdd:cd09926  75 DQEFDDLPALLEFYKLH 91
SH3_CSK cd11769
Src Homology 3 domain of C-terminal Src kinase; CSK is a cytoplasmic (or nonreceptor) tyr ...
95-145 8.80e-11

Src Homology 3 domain of C-terminal Src kinase; CSK is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, CSK is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. CSK catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. It is expressed in a wide variety of tissues and plays a role, as a regulator of Src, in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. In addition, CSK also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212703 [Multi-domain]  Cd Length: 57  Bit Score: 57.31  E-value: 8.80e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   95 VALYDYEARTTEDLSFKKGERFQIINNTEG-DWWEARSiATGKSGYIPSNYV 145
Cdd:cd11769   5 IAKYNFNGASEEDLPFKKGDILTIVAVTKDpNWYKAKN-KDGREGMIPANYV 55
SH3_ARHGAP9_like cd11888
Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins; This subfamily ...
95-144 9.31e-11

Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins; This subfamily is composed of Rho GTPase-activating proteins including mammalian ARHGAP9, and vertebrate ARHGAPs 12 and 27. RhoGAPs (or ARHGAPs) bind to Rho proteins and enhance the hydrolysis rates of bound GTP. ARHGAP9 functions as a GAP for Rac and Cdc42, but not for RhoA. It negatively regulates cell migration and adhesion. It also acts as a docking protein for the MAP kinases Erk2 and p38alpha, and may facilitate cross-talk between the Rho GTPase and MAPK pathways to control actin remodeling. ARHGAP27, also called CAMGAP1, shows GAP activity towards Rac1 and Cdc42. It binds the adaptor protein CIN85 and may play a role in clathrin-mediated endocytosis. ARHGAP12 has been shown to display GAP activity towards Rac1. It plays a role in regulating HFG-driven cell growth and invasiveness. ARHGAPs in this subfamily contain SH3, WW, Pleckstin homology (PH), and RhoGAP domains. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.


Pssm-ID: 212821 [Multi-domain]  Cd Length: 54  Bit Score: 57.38  E-value: 9.31e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   95 VALYDYEARTTED--LSFKKGERFQIINNTEGDWWEARSIATGKSGYIPSNY 144
Cdd:cd11888   3 VVLYPFEYTGKDGrkVSIKEGERFLLLKKSNDDWWQVRRPGDSKPFYVPAQY 54
SH3_Sho1p cd11855
Src homology 3 domain of High osmolarity signaling protein Sho1p; Sho1p (or Sho1), also called ...
96-145 1.01e-10

Src homology 3 domain of High osmolarity signaling protein Sho1p; Sho1p (or Sho1), also called SSU81 (Suppressor of SUA8-1 mutation), is a yeast membrane protein that regulates adaptation to high salt conditions by activating the HOG (high-osmolarity glycerol) pathway. High salt concentrations lead to the localization to the membrane of the MAPKK Pbs2, which is then activated by the MAPKK Ste11 and in turn, activates the MAPK Hog1. Pbs2 is localized to the membrane though the interaction of its PxxP motif with the SH3 domain of Sho1p. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212789 [Multi-domain]  Cd Length: 55  Bit Score: 57.04  E-value: 1.01e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6678617   96 ALYDYEARTTE--DLSFKKGERFQIInNTEGDWWEARSiATGKSGYIPSNYV 145
Cdd:cd11855   4 ALYPYDASPDDpnELSFEKGEILEVS-DTSGKWWQARK-SNGETGICPSNYL 53
SH2_a2chimerin_b2chimerin cd10352
Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins; Chimerins ...
157-247 1.14e-10

Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins; Chimerins are a family of phorbol ester- and diacylglycerol-responsive GTPase-activating proteins. Alpha1-chimerin (formerly known as n-chimerin) and alpha2-chimerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimerin. alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. All of the isoforms contain a GAP domain with specificity in vitro for Rac1 and a diacylglycerol (DAG)-binding C1 domain which allows them to translocate to membranes in response to DAG signaling and anchors them in close proximity to activated Rac. Other C1 domain-containing diacylglycerol receptors including: PKC, Munc-13 proteins, phorbol ester binding scaffolding proteins involved in Ca2+-stimulated exocytosis, and RasGRPs, diacylglycerol-activated guanine-nucleotide exchange factors (GEFs) for Ras and Rap1. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198215  Cd Length: 91  Bit Score: 58.14  E-value: 1.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  157 YFGKMGRKDAERLLLNPGNqrGIFLVRESETTKGAYSLSIRdwdevRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVk 236
Cdd:cd10352   9 YHGLISREEAEQLLSGASD--GSYLIRESSRDDGYYTLSLR-----FNGKVKNYKLYYDGKNHYHYVGEKRFDTIHDLV- 80
                        90
                ....*....|.
gi 6678617  237 hytehADGLCH 247
Cdd:cd10352  81 -----ADGLIT 86
SH2_C-SH2_Zap70_Syk_like cd10345
C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 ...
156-254 1.20e-10

C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins; ZAP-70 and Syk comprise a family of hematopoietic cell specific protein tyrosine kinases (PTKs) that are required for antigen and antibody receptor function. ZAP-70 is expressed in T and natural killer (NK) cells and Syk is expressed in B cells, mast cells, polymorphonuclear leukocytes, platelets, macrophages, and immature T cells. They are required for the proper development of T and B cells, immune receptors, and activating NK cells. They consist of two N-terminal Src homology 2 (SH2) domains and a C-terminal kinase domain separated from the SH2 domains by a linker or hinge region. Phosphorylation of both tyrosine residues within the Immunoreceptor Tyrosine-based Activation Motifs (ITAM; consensus sequence Yxx[LI]x(7,8)Yxx[LI]) by the Src-family PTKs is required for efficient interaction of ZAP-70 and Syk with the receptor subunits and for receptor function. ZAP-70 forms two phosphotyrosine binding pockets, one of which is shared by both SH2 domains. In Syk the two SH2 domains do not form such a phosphotyrosine-binding site. The SH2 domains here are believed to function independently. In addition, the two SH2 domains of Syk display flexibility in their relative orientation, allowing Syk to accommodate a greater variety of spacing sequences between the ITAM phosphotyrosines and singly phosphorylated non-classical ITAM ligands. This model contains the C-terminus SH2 domains of both Syk and Zap70. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.


Pssm-ID: 198208  Cd Length: 95  Bit Score: 58.16  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  156 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETtKGAYSLSIrdwdeVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV 235
Cdd:cd10345   2 WFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCL-----LHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLV 75
                        90
                ....*....|....*....
gi 6678617  236 KHYTEHADGLCHKLTTVCP 254
Cdd:cd10345  76 EHYSYKADGLLRVLTVPCQ 94
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
280-516 1.22e-10

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 62.29  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVWMG--TWNGTTkVAIKTLKpgtmmpEAF--------LQEAQIMKKLR-HDKLVPLYAVVSEEP---IYIV 345
Cdd:cd07831   6 KIGEGTFSEVLKAqsRKTGKY-YAIKCMK------KHFksleqvnnLREIQALRRLSpHPNILRLIEVLFDRKtgrLALV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSkGSLLDFLKeGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLIcKIADFGLARLIED---- 421
Cdd:cd07831  79 FELMD-MNLYELIK-GRKRPLPEKRVKNYMYQLLKSLDHMHRNGIFHRDIKPENILIKDDIL-KLADFGSCRGIYSkppy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  422 NEYTArqgakfpIKW-TAPEAALY-GRFTIKSDVWSFGILQTELVTkgRVP-YPG-----MVNR----------EVLEQV 483
Cdd:cd07831 156 TEYIS-------TRWyRAPECLLTdGYYGPKMDIWAVGCVFFEILS--LFPlFPGtneldQIAKihdvlgtpdaEVLKKF 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6678617  484 ERGYRM-------------PCPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd07831 227 RKSRHMnynfpskkgtglrKLLPNASAEGLDLLKKLLAYDPDERIT 272
PTKc_Wee1a cd14138
Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the ...
280-516 1.80e-10

Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of human Wee1a, Xenopus laevis Wee1b (XeWee1b) and similar vertebrate proteins. Members of this subfamily show a wide expression pattern. XeWee1b functions after the first zygotic cell divisions. It is expressed in all tissues and is also present after the gastrulation stage of embryos. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The Wee1a subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271040 [Multi-domain]  Cd Length: 276  Bit Score: 61.96  E-value: 1.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  280 KLGQGCFGEVW--MGTWNGTTKVAIKTLKP--GTMMPEAFLQEAQIMKKL-RHDKLVPLYAVVSEEP-IYIVTEFMSKGS 353
Cdd:cd14138  12 KIGSGEFGSVFkcVKRLDGCIYAIKRSKKPlaGSVDEQNALREVYAHAVLgQHSHVVRYYSAWAEDDhMLIQNEYCNGGS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  354 LLDFLKEG--DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-------------------GENLICKIAD 412
Cdd:cd14138  92 LADAISENyrIMSYFTEPELKDLLLQVARGLKYIHSMSLVHMDIKPSNIFIsrtsipnaaseegdedewaSNKVIFKIGD 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  413 FGLARLIedneyTARQGAKFPIKWTAPEAaLYGRFT--IKSDVwsFGILQTELVTKGRVPYPgmVNREVLEQVERGyRMP 490
Cdd:cd14138 172 LGHVTRV-----SSPQVEEGDSRFLANEV-LQENYThlPKADI--FALALTVVCAAGAEPLP--TNGDQWHEIRQG-KLP 240
                       250       260
                ....*....|....*....|....*..
gi 6678617  491 -CPQGCPESLHELMNLCWKKDPDERPT 516
Cdd:cd14138 241 rIPQVLSQEFLDLLKVMIHPDPERRPS 267
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
281-514 1.87e-10

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 62.42  E-value: 1.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWM-----GTWNGTTkVAIKTLKPGTMMPEA-----FLQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVTEFM 349
Cdd:cd05584   4 LGKGGYGKVFQvrkttGSDKGKI-FAMKVLKKASIVRNQkdtahTKAERNILEAVKHPFIVDLhYAFQTGGKLYLILEYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  350 SKGSLLDFLkEGDGKYLKlpqlvDMA----AQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNEY 424
Cdd:cd05584  83 SGGELFMHL-EREGIFME-----DTAcfylAEITLALGHLHSLGIIYRDLKPENILLDAQGHVKLTDFGLCKeSIHDGTV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  425 TarqgAKF--PIKWTAPEAAL---YGRftiKSDVWSFGILQTELVTkGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 499
Cdd:cd05584 157 T----HTFcgTIEYMAPEILTrsgHGK---AVDWWSLGALMYDMLT-GAPPFTAENRKKTIDKILKGKLNLPPYLTNEAR 228
                       250
                ....*....|....*
gi 6678617  500 HELMNLCwKKDPDER 514
Cdd:cd05584 229 DLLKKLL-KRNVSSR 242
SH3_PIX cd11877
Src Homology 3 domain of Pak Interactive eXchange factors; PIX proteins are Rho guanine ...
96-145 1.87e-10

Src Homology 3 domain of Pak Interactive eXchange factors; PIX proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac 1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX subfamily, alpha-PIX and beta-PIX. Alpha-PIX, also called ARHGEF6, is localized in dendritic spines where it regulates spine morphogenesis. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX play roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. PIX proteins contain an N-terminal SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains, and a C-terminal leucine-zipper domain for dimerization. The SH3 domain of PIX binds to an atypical PxxxPR motif in p21-activated kinases (PAKs) with high affinity. The binding of PAKs to PIX facilitate the localization of PAKs to focal complexes and also localizes PAKs to PIX targets Cdc43 and Rac, leading to the activation of PAKs. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212810 [Multi-domain]  Cd Length: 53  Bit Score: 56.17  E-value: 1.87e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617   96 ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEArsIATGKSGYIPSNYV 145
Cdd:cd11877   4 AKFNFEGTNEDELSFDKGDIITVTQVVEGGWWEG--TLNGKTGWFPSNYV 51
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
327-478 2.09e-10

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 61.60  E-value: 2.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  327 HDKLVPLYAVV---SEepIYIVTEFMSKGSLLDFLKEGDgkYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 403
Cdd:cd14106  67 CPRVVNLHEVYetrSE--LILILELAAGGELQTLLDEEE--CLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLT 142
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678617  404 ENLIC---KIADFGLARLIEDNEyTARQGAKFPiKWTAPEAALYGRFTIKSDVWSFGILQTELVTkGRVPYPGMVNRE 478
Cdd:cd14106 143 SEFPLgdiKLCDFGISRVIGEGE-EIREILGTP-DYVAPEILSYEPISLATDMWSIGVLTYVLLT-GHSPFGGDDKQE 217
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
276-471 2.09e-10

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 61.08  E-value: 2.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  276 RLEVKLGQGCFGEVWMGT--------WNGTTKVAIKTLKPgTMMPEAFLQEAQIMKKLR-HDKLVPL-YAVVSEEPIYIV 345
Cdd:cd14019   4 RIIEKIGEGTFSSVYKAEdklhdlydRNKGRLVALKHIYP-TSSPSRILNELECLERLGgSNNVSGLiTAFRNEDQVVAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  346 TEFMSKGSLLDFLKEGD----GKYLKlpqlvdmaaQIADGMAYIERMNYIHRDLRAANIL----VGENLICkiaDFGLAR 417
Cdd:cd14019  83 LPYIEHDDFRDFYRKMSltdiRIYLR---------NLFKALKHVHSFGIIHRDVKPGNFLynreTGKGVLV---DFGLAQ 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6678617  418 LIEDneytaRQGAKFPIKWT----APEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPY 471
Cdd:cd14019 151 REED-----RPEQRAPRAGTrgfrAPEVLFkCPHQTTAIDIWSAGVILLSILSGRFPFF 204
SH3_SPIN90 cd11849
Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90); SPIN90 is also ...
96-145 2.10e-10

Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90); SPIN90 is also called NCK interacting protein with SH3 domain (NCKIPSD), Dia-interacting protein (DIP), 54 kDa vimentin-interacting protein (VIP54), or WASP-interacting SH3-domain protein (WISH). It is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with the Arp2/3 complex near actin filaments and determines filament localization at the leading edge of lamellipodia. SPIN90 is expressed in the early stages of neuronal differentiation and plays a role in regulating growth cone dynamics and neurite outgrowth. It also interacts with IRSp53 and regulates cell motility by playing a role in the formation of membrane protrusions. SPIN90 contains an N-terminal SH3 domain, a proline-rich domain, and a C-terminal VCA (verprolin-homology and cofilin-like acidic) domain. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212783 [Multi-domain]  Cd Length: 53  Bit Score: 56.17  E-value: 2.10e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6678617   96 ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIaTGKSGYIPSNYV 145
Cdd:cd11849   4 ALYDFKSAEPNTLSFSEGETFLLLERSNAHWWLVTNH-SGETGYVPANYV 52
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
272-459 2.13e-10

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 61.53  E-value: 2.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  272 RESLRLEVKLGQGCFGEVWMGTWNGTTKVAikTLK----PGTMMPEAFLQEAQIMKKLR-HDKLVPL---YAVVSEEPIY 343
Cdd:cd14037   2 SHHVTIEKYLAEGGFAHVYLVKTSNGGNRA--ALKrvyvNDEHDLNVCKREIEIMKRLSgHKNIVGYidsSANRSGNGVY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  344 ---IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAyieRMNY-----IHRDLRAANILVGENLICKIADFGL 415
Cdd:cd14037  80 evlLLMEYCKGGGVIDLMNQRLQTGLTESEILKIFCDVCEAVA---AMHYlkpplIHRDLKVENVLISDSGNYKLCDFGS 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6678617  416 A---RLIEDNEYTARQGAKFPIKWT-----APEAA-LYGRFTI--KSDVWSFGIL 459
Cdd:cd14037 157 AttkILPPQTKQGVTYVEEDIKKYTtlqyrAPEMIdLYRGKPIteKSDIWALGCL 211
SH3_Nephrocystin cd11770
Src Homology 3 domain of Nephrocystin (or Nephrocystin-1); Nephrocystin contains an SH3 domain ...
93-145 2.16e-10

Src Homology 3 domain of Nephrocystin (or Nephrocystin-1); Nephrocystin contains an SH3 domain involved in signaling pathways that regulate cell adhesion and cytoskeletal organization. It is a protein that in humans is associated with juvenile nephronophthisis, an inherited kidney disease characterized by renal fibrosis that lead to chronic renal failure in children. It is localized in cell-cell junctions in renal duct cells, and is known to interact with Ack1, an activated Cdc42-associated kinase. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212704 [Multi-domain]  Cd Length: 54  Bit Score: 56.17  E-value: 2.16e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6678617   93 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSiATGKSGYIPSNYV 145
Cdd:cd11770   1 LYEALSDFQAEQEGDLSFKKGEVLRIISKRADGWWLAEN-SKGNRGLVPKTYL 52
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
281-516 2.22e-10

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 61.55  E-value: 2.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  281 LGQGCFGEVWMGTWNGTTKV-AIKTLKPGTMM-PEAFLQ-EAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLD 356
Cdd:cd14183  14 IGDGNFAVVKECVERSTGREyALKIINKSKCRgKEHMIQnEVSILRRVKHPNIVLLIEEMdMPTELYLVMELVKGGDLFD 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  357 FLKEGDgKYLKlPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENL----ICKIADFGLARLIEDNEYTArqgAKF 432
Cdd:cd14183  94 AITSTN-KYTE-RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQdgskSLKLGDFGLATVVDGPLYTV---CGT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678617  433 PiKWTAPEAALYGRFTIKSDVWSFGILqTELVTKGRVPYPGMV-NREVL-EQVERG---YRMPCPQGCPESLHELMNLCW 507
Cdd:cd14183 169 P-TYVAPEIIAETGYGLKVDIWAAGVI-TYILLCGFPPFRGSGdDQEVLfDQILMGqvdFPSPYWDNVSDSAKELITMML 246

                ....*....
gi 6678617  508 KKDPDERPT 516
Cdd:cd14183 247 QVDVDQRYS 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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