NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|86476066|ref|NP_033586|]
View 

zinc finger protein 60 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 3.68e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86476066     14 VTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAvVGRCIPKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-640 2.09e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.27  E-value: 2.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 212 LPQMLSRHQKSHSDERPFECNICGKSFHLPTLLQYHKNIHTGLKPFEC--EECGKSFNRISTLFQH-RTIHAGMKPYKCN 288
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHlRTHHNNPSDLNSK 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 289 VCGKAFNRRSNLLQHQKIHSEDRPFHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNG-SYLLRHYDTHTNEK 367
Cdd:COG5048  97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 368 PFECNICGKAFRlhlylsehQKTHTDEKPFKCKLCESAFRRKYQ-LSEHQRIHTDVKPYQCKDCGKFFRRRSNFTEHQSI 446
Cdd:COG5048 177 SKDPSSNLSLLI--------SSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 447 HTGKKPFECKDCGKVFRLNIHLIRHQRFHSDE-------KPFECKECGKAFHFSSQLNNHK--TSHTGQ--TPFECKE-- 513
Cdd:COG5048 249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 514 CGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNL-------MQHEKIHSDERPFEC--KDCGKAFTVLAQLTRHQ 584
Cdd:COG5048 329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 86476066 585 TIHNGKKSYECE--QCGSAFRLPYQLTQHQRIHYDVKPFQCKECGKGFVRSTGLRIHE 640
Cdd:COG5048 409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
636-658 2.00e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|...
gi 86476066   636 LRIHERIHTGEKPFQCKECGEAF 658
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 3.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86476066     14 VTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAvVGRCIPKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 4.03e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 86476066    13 SVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 2.03e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.03e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 86476066  14 VTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLV 51
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-640 2.09e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.27  E-value: 2.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 212 LPQMLSRHQKSHSDERPFECNICGKSFHLPTLLQYHKNIHTGLKPFEC--EECGKSFNRISTLFQH-RTIHAGMKPYKCN 288
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHlRTHHNNPSDLNSK 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 289 VCGKAFNRRSNLLQHQKIHSEDRPFHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNG-SYLLRHYDTHTNEK 367
Cdd:COG5048  97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 368 PFECNICGKAFRlhlylsehQKTHTDEKPFKCKLCESAFRRKYQ-LSEHQRIHTDVKPYQCKDCGKFFRRRSNFTEHQSI 446
Cdd:COG5048 177 SKDPSSNLSLLI--------SSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 447 HTGKKPFECKDCGKVFRLNIHLIRHQRFHSDE-------KPFECKECGKAFHFSSQLNNHK--TSHTGQ--TPFECKE-- 513
Cdd:COG5048 249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 514 CGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNL-------MQHEKIHSDERPFEC--KDCGKAFTVLAQLTRHQ 584
Cdd:COG5048 329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 86476066 585 TIHNGKKSYECE--QCGSAFRLPYQLTQHQRIHYDVKPFQCKECGKGFVRSTGLRIHE 640
Cdd:COG5048 409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
636-658 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|...
gi 86476066   636 LRIHERIHTGEKPFQCKECGEAF 658
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*
gi 86476066   244 LQYHKNIHTGLKPFECEECGKSFNR 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 3.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.68e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86476066     14 VTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAvVGRCIPKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 4.03e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 86476066    13 SVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 2.03e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.03e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 86476066  14 VTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLV 51
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-640 2.09e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.27  E-value: 2.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 212 LPQMLSRHQKSHSDERPFECNICGKSFHLPTLLQYHKNIHTGLKPFEC--EECGKSFNRISTLFQH-RTIHAGMKPYKCN 288
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHlRTHHNNPSDLNSK 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 289 VCGKAFNRRSNLLQHQKIHSEDRPFHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNG-SYLLRHYDTHTNEK 367
Cdd:COG5048  97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 368 PFECNICGKAFRlhlylsehQKTHTDEKPFKCKLCESAFRRKYQ-LSEHQRIHTDVKPYQCKDCGKFFRRRSNFTEHQSI 446
Cdd:COG5048 177 SKDPSSNLSLLI--------SSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 447 HTGKKPFECKDCGKVFRLNIHLIRHQRFHSDE-------KPFECKECGKAFHFSSQLNNHK--TSHTGQ--TPFECKE-- 513
Cdd:COG5048 249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYsl 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 514 CGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNL-------MQHEKIHSDERPFEC--KDCGKAFTVLAQLTRHQ 584
Cdd:COG5048 329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 86476066 585 TIHNGKKSYECE--QCGSAFRLPYQLTQHQRIHYDVKPFQCKECGKGFVRSTGLRIHE 640
Cdd:COG5048 409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-572 1.76e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 140 QNYQEGDANRNITNKKEMSTYTSKTLAHNKEKPYKCKDCGKCFGCKSNLHQHESIHTGEKPYECKD--CGKTFRLPQMLS 217
Cdd:COG5048   1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 218 RHQKSHSDERPFECNICGKSFHLPTLlqYHKNIHTGLKPFECE-ECGKSFNRISTLFQHRTIHAGMKpYKCNVCGKAFNR 296
Cdd:COG5048  81 RHLRTHHNNPSDLNSKSLPLSNSKAS--SSSLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 297 RSNLLQHQKIHSEDRPFHCKvcgKAFTVLAQLTRHENIHTEDKSFECKQCGKIFsngSYLLRHYDTHTNEKPFE---CNI 373
Cdd:COG5048 158 SVNTPQSNSLHPPLPANSLS---KDPSSNLSLLISSNVSTSIPSSSENSPLSSS---YSIPSSSSDQNLENSSSslpLTT 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 374 CGKAFRLHLYLSEHQKTHTDEKPFKCKLCESAFRRKYQLSEHQRIHTDV-------KPYQCKDCGKFFRRRSNFTEHQ-- 444
Cdd:COG5048 232 NSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrs 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 445 SIHTGK--KPFEC--KDCGKVFRLNIHLIRHQRFHSDEKPFECK--ECGKAFHFSS------QLNNHKTSHTGQtPFEC- 511
Cdd:COG5048 312 VNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppqSLQQYKDLKNDK-KSETl 390

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 86476066 512 -KECGKSFKRVSSLVEHRIIHSGVKP--YKCNACGRAFNRRSNLMQHEKIHSDERPFECKDCGK 572
Cdd:COG5048 391 sNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-656 6.24e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 6.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 367 KPFECNICGKAFRLHLYLSEHQKTHTDEKPFKC--KLCESAFRRKYQLSEHQRIHTDVKPYQCKDCG----------KFF 434
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskasssSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 435 RRRSNFTEHQSI------HTGKKPFECKDCGKVFRLNIHLIRHQRFHSDEK-------PFECKECGKAFHFSSQLNNHKT 501
Cdd:COG5048 112 SSSSNSNDNNLLsshslpPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 502 SHTGQTPFECKECGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNLMQHEKIHSDERPFECKDCGKAFTVLAQLT 581
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 582 RHQTIHNG-------KKSYECEQCGSAFRLPYQLTQHQR--IH--YDVKPFQCKE--CGKGFVRSTGLRIHERIHTGEKP 648
Cdd:COG5048 272 SSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                ....*...
gi 86476066 649 FQCKECGE 656
Cdd:COG5048 352 AKEKLLNS 359
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-361 1.72e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 126 SVSNGPGYSVIKEPQNYQEGDANRNITNKKEMSTYTSKTLAHNKEKPYKCKDCGKCFGCKSNLHQHESIHTGE------- 198
Cdd:COG5048 208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 199 KPYECKDCGKTFRLPQMLSRHQKSHSDE----RPFEC--NICGKSFHLPTLLQYHKNIHTGLKPFEC--EECGKSFNRIS 270
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 271 T-----LFQHRTIHAGMKPYKCNV--CGKAFNRRSNLLQHQKIHSEDRP--FHCKVCGKAFTVLAQLTRHENIHTEDKSF 341
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       250       260
                ....*....|....*....|
gi 86476066 342 ECKQCGKIFSNGSYLLRHYD 361
Cdd:COG5048 448 LCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
636-658 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|...
gi 86476066   636 LRIHERIHTGEKPFQCKECGEAF 658
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*
gi 86476066   244 LQYHKNIHTGLKPFECEECGKSFNR 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
551-575 4.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|....*
gi 86476066   551 NLMQHEKIHSDERPFECKDCGKAFT 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 217-310 4.33e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86476066 217 SRHQKShSDERPFECNI--CGKSFHLPTLLQYHK---NIHTGLKPFECEECGKSFNristlfqhrtihAGMKPYKCNVCG 291
Cdd:COG5189 339 SRMLKV-KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIFS------------AKDKPYRCEVCD 405

                        90
                ....*....|....*....
gi 86476066 292 KAFNRRSNLLQHQKiHSED 310
Cdd:COG5189 406 KRYKNLNGLKYHRK-HSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-490 4.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.76e-03
                          10        20
                  ....*....|....*....|....
gi 86476066   467 HLIRHQRFHSDEKPFECKECGKAF 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 285-307 7.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.29e-03
                          10        20
                  ....*....|....*....|...
gi 86476066   285 YKCNVCGKAFNRRSNLLQHQKIH 307
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 7.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.33e-03
                          10        20
                  ....*....|....*....|....*
gi 86476066   496 LNNHKTSHTGQTPFECKECGKSFKR 520
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH