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Conserved domains on  [gi|148276996|ref|NP_033590|]
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zinc finger protein 64 isoform 1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-448 2.50e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 149 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 228
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 229 FKCQICPYASR------NSSQLTVHLRSHTG-DAPFQCWLCSAKFKISSDLKRHMR--VHSGE--KPFKC--EFCNVRCT 295
Cdd:COG5048  255 SSASESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFS 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 296 MKGNLKSHIRIKHSGNNFKCphCDFLGDSKSTLRKHSRLHQSEhpekcpecsyscsskaalrvherihcterpfkcsycs 375
Cdd:COG5048  335 RNDALKRHILLHTSISPAKE--KLLNSSSKFSPLLNNEPPQSL------------------------------------- 375

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148276996 376 fdtkQPSNLSKHMKKFHADMLKNEAPEKKESGRQSSRQVARLDAKKTFHCDICDASFMREDSLRSHKRQHSEY 448
Cdd:COG5048  376 ----QQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-448 2.50e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 149 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 228
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 229 FKCQICPYASR------NSSQLTVHLRSHTG-DAPFQCWLCSAKFKISSDLKRHMR--VHSGE--KPFKC--EFCNVRCT 295
Cdd:COG5048  255 SSASESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFS 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 296 MKGNLKSHIRIKHSGNNFKCphCDFLGDSKSTLRKHSRLHQSEhpekcpecsyscsskaalrvherihcterpfkcsycs 375
Cdd:COG5048  335 RNDALKRHILLHTSISPAKE--KLLNSSSKFSPLLNNEPPQSL------------------------------------- 375

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148276996 376 fdtkQPSNLSKHMKKFHADMLKNEAPEKKESGRQSSRQVARLDAKKTFHCDICDASFMREDSLRSHKRQHSEY 448
Cdd:COG5048  376 ----QQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 2.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.35e-05
                          10        20
                  ....*....|....*....|....*.
gi 148276996  159 DMERHLKIHTGDKPHKCEVCGKCFSR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-448 2.50e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 149 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 228
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 229 FKCQICPYASR------NSSQLTVHLRSHTG-DAPFQCWLCSAKFKISSDLKRHMR--VHSGE--KPFKC--EFCNVRCT 295
Cdd:COG5048  255 SSASESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFS 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 296 MKGNLKSHIRIKHSGNNFKCphCDFLGDSKSTLRKHSRLHQSEhpekcpecsyscsskaalrvherihcterpfkcsycs 375
Cdd:COG5048  335 RNDALKRHILLHTSISPAKE--KLLNSSSKFSPLLNNEPPQSL------------------------------------- 375

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148276996 376 fdtkQPSNLSKHMKKFHADMLKNEAPEKKESGRQSSRQVARLDAKKTFHCDICDASFMREDSLRSHKRQHSEY 448
Cdd:COG5048  376 ----QQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 2.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.35e-05
                          10        20
                  ....*....|....*....|....*.
gi 148276996  159 DMERHLKIHTGDKPHKCEVCGKCFSR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-209 1.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|..
gi 148276996  188 LKTHMRCHTGVKPYKCKTCDYA 209
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-290 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|
gi 148276996  271 DLKRHMRVHSGEKPFKCEFC 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
369-390 5.39e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.53  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|..
gi 148276996  369 FKCSYCSFDTKQPSNLSKHMKK 390
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRK 22
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
201-224 1.29e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.37  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....
gi 148276996  201 YKCKTCDYAAADSSSLNKHLRIHS 224
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-309 1.57e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 225 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 301
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*...
gi 148276996 302 SHirIKHS 309
Cdd:COG5189  416 YH--RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
113-446 2.02e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 113 STDNQTATVISLPTKSRTKKPTAPPAQKRlgCCYPGCQFKTAYGMKdmeRHLKIHTGDKPHKCEV--CGKCFSRKDKLKT 190
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNAPRPDS--CPNCTDSFSRLEHLT---RHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 191 HMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHS-DERPFKCQICPYASRNSSQLTVHLRSHT----------------- 252
Cdd:COG5048   82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrnnplpgnnsssvnt 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 253 ---GDAPFQCWLCSAKFKISSDLKR--HMRVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKST 327
Cdd:COG5048  162 pqsNSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 328 LRKHSRLHQSEHPEKCPECSYSCSSKAALRVH--------ERIHCTErPFKCSYCSFDTKQPSNLSKHMKKFHADMLKNE 399
Cdd:COG5048  242 SQSPSSLSSSDSSSSASESPRSSLPTASSQSSspnesdssSEKGFSL-PIKSKQCNISFSRSSPLTRHLRSVNHSGESLK 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 148276996 400 APEKKESgrqssrqvarldakktfhcdICDASFMREDSLRSHKRQHS 446
Cdd:COG5048  321 PFSCPYS--------------------LCGKLFSRNDALKRHILLHT 347
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 173-193 2.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|.
gi 148276996  173 HKCEVCGKCFSRKDKLKTHMR 193
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-288 2.95e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 164 LKIHTG--DKPHKC--EVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNK----HLRIHSDERPFKCQICP 235
Cdd:COG5048  311 SVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETL 390

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 236 YASRNS-----SQLTVHLRSHTGDAP--FQCWLCSAKFKISSDLKRHMRVHSGEKPFKCE 288
Cdd:COG5048  391 SNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
313-335 4.54e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|...
gi 148276996  313 FKCPHCDFLGDSKSTLRKHSRLH 335
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-325 6.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 170 DKPHKCEVCGKCFSRKDKLKTHMRC--HTG--VKPYKC--KTCDYAAADSSSLNKHLRIHSDERPFKCQI---------- 233
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnssskfspl 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148276996 234 ---CPYASRNSSQLTVHLRSHTGDAPFQCWLCSAKFKISSDLKRHMRvhSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSG 310
Cdd:COG5048  367 lnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                        170
                 ....*....|....*.
gi 148276996 311 NNFKC-PHCDFLGDSK 325
Cdd:COG5048  445 APLLCsILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 8.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 148276996  215 SLNKHLRIHSDERPFKCQICPYASRN 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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