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Conserved domains on  [gi|33563242|ref|NP_033793|]
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arachidonate 5-lipoxygenase-activating protein isoform 1 [Mus musculus]

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein similar to mammalian prostaglandin E synthase and leukotriene C4 synthase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 9-128 1.36e-08

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 50.37  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33563242     9 VVLLALVTLI--SVVQNAFFAHKVeHESKAHNGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLL-CSQVPAAF 85
Cdd:pfam01124   5 AVLLALLLLLlsILVGKARKKAKV-GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGLAAL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 33563242    86 AGLMYLFVRQKYFVGYLGERTQS-TPGYIFGKRIILFLFLMSFA 128
Cdd:pfam01124  84 LAWAYVVARVLHALGYATGNPPLrSLGFLLGFLALLALAVLALL 127
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 9-128 1.36e-08

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 50.37  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33563242     9 VVLLALVTLI--SVVQNAFFAHKVeHESKAHNGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLL-CSQVPAAF 85
Cdd:pfam01124   5 AVLLALLLLLlsILVGKARKKAKV-GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGLAAL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 33563242    86 AGLMYLFVRQKYFVGYLGERTQS-TPGYIFGKRIILFLFLMSFA 128
Cdd:pfam01124  84 LAWAYVVARVLHALGYATGNPPLrSLGFLLGFLALLALAVLALL 127
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 9-128 1.36e-08

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 50.37  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33563242     9 VVLLALVTLI--SVVQNAFFAHKVeHESKAHNGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLL-CSQVPAAF 85
Cdd:pfam01124   5 AVLLALLLLLlsILVGKARKKAKV-GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTgGSPGLAAL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 33563242    86 AGLMYLFVRQKYFVGYLGERTQS-TPGYIFGKRIILFLFLMSFA 128
Cdd:pfam01124  84 LAWAYVVARVLHALGYATGNPPLrSLGFLLGFLALLALAVLALL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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