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Conserved domains on  [gi|170172524|ref|NP_034243|]
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pro-epidermal growth factor isoform 1 preproprotein [Mus musculus]

Protein Classification

FXa_inhibition and LY domain-containing protein( domain architecture ID 13891139)

protein containing domains FXa_inhibition, LY, and EGF_CA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 5.78e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.78e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 4.60e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 4.60e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 8.20e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 8.20e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 2.66e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
919-947 4.89e-08

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 49.93  E-value: 4.89e-08
                           10        20
                   ....*....|....*....|....*....
gi 170172524   919 DIDECQRGAHNCGENAACTNTEGGYNCTC 947
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 8.03e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 8.03e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 1.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 48.77  E-value: 1.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 170172524   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 3.90e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 170172524   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 5.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 5.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 9.44e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 9.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 170172524    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
PHA02887 super family cl31518
EGF-like protein; Provisional
982-1019 5.52e-05

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 170172524  982 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 8.95e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 8.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 170172524    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 2.68e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.68e-04
                           10        20
                   ....*....|....*....|....*....
gi 170172524   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 2.86e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 2.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 5.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.27e-03
                            10        20
                    ....*....|....*....|....*....
gi 170172524     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 5.78e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.78e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 4.60e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 4.60e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 8.20e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 8.20e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 2.66e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
919-947 4.89e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 49.93  E-value: 4.89e-08
                           10        20
                   ....*....|....*....|....*....
gi 170172524   919 DIDECQRGAHNCGENAACTNTEGGYNCTC 947
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
616-656 6.27e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 49.86  E-value: 6.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITID 656
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 8.03e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 8.03e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
358-399 8.68e-08

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 54.31  E-value: 8.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 170172524  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 1.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 48.77  E-value: 1.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 170172524   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 3.90e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 170172524   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
660-699 4.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 47.16  E-value: 4.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVF 699
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 5.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 5.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 5.80e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 5.80e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 170172524    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
573-612 1.21e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 46.01  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   573 RRIYWTDSG-KSVVGGSDLSGKHHRIIIQERISRPRGIAVH 612
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
877-917 6.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 170172524    877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEgDGISC 917
Cdd:smart00179    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 9.44e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 9.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 170172524    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
919-947 1.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....*....
gi 170172524  919 DIDECQRGaHNCGENAACTNTEGGYNCTC 947
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
919-947 1.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.93e-05
                            10        20
                    ....*....|....*....|....*....
gi 170172524    919 DIDECQRGaHNCGENAACTNTEGGYNCTC 947
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
877-913 2.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 170172524  877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 913
Cdd:cd00054     1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35
PHA02887 PHA02887
EGF-like protein; Provisional
982-1019 5.52e-05

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 170172524  982 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 8.95e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 8.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 170172524    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 2.68e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.68e-04
                           10        20
                   ....*....|....*....|....*....
gi 170172524   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
990-1019 2.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.49e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 170172524  990 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 2.86e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 2.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 5.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.27e-03
                            10        20
                    ....*....|....*....|....*....
gi 170172524     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
596-639 5.78e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 5.78e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    596 RIIIQERISRPRGIAVHPRARRLFWTDVGMsPRIESASLQGSDR 639
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
639-682 4.60e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 4.60e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    639 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 682
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
553-595 8.20e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 8.20e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    553 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 595
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
366-401 2.66e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   366 CATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQC 401
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
919-947 4.89e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 49.93  E-value: 4.89e-08
                           10        20
                   ....*....|....*....|....*....
gi 170172524   919 DIDECQRGAHNCGENAACTNTEGGYNCTC 947
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
616-656 6.27e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 49.86  E-value: 6.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   616 RRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITID 656
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
510-552 8.03e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 8.03e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 170172524    510 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
358-399 8.68e-08

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 54.31  E-value: 8.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 170172524  358 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGK 399
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
445-482 1.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 48.77  E-value: 1.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 170172524   445 CSSpDNGGCSQICLPlRPGSWECDCFPGYDLQSDRKSC 482
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
877-909 3.90e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 170172524   877 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 909
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
660-699 4.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 47.16  E-value: 4.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   660 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVF 699
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
751-786 5.12e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 5.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 170172524   751 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 786
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 5.80e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 5.80e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 170172524    362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpDGKQC 401
Cdd:smart00179    1 DIDECAS-GNPCQNGgtCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
573-612 1.21e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 46.01  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 170172524   573 RRIYWTDSG-KSVVGGSDLSGKHHRIIIQERISRPRGIAVH 612
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
923-947 1.94e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 432893  Cd Length: 36  Bit Score: 45.28  E-value: 1.94e-06
                           10        20
                   ....*....|....*....|....*
gi 170172524   923 CQRGAHNCGENAACTNTEGGYNCTC 947
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTC 25
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
895-917 3.07e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 432893  Cd Length: 36  Bit Score: 44.90  E-value: 3.07e-06
                           10        20
                   ....*....|....*....|...
gi 170172524   895 CINTEGGYVCRCSEGYEGDGISC 917
Cdd:pfam12947   14 CTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
362-401 4.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 170172524  362 DVNECATqNHGCTLG--CENTPGSYHCTCPTGFVllpdGKQC 401
Cdd:cd00054     1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYT----GRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
877-917 6.10e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 170172524    877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEgDGISC 917
Cdd:smart00179    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCECPPGYT-DGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
158-199 9.44e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 9.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 170172524    158 RVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDV 199
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
366-401 1.40e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 432893  Cd Length: 36  Bit Score: 42.97  E-value: 1.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 170172524   366 CATQNHGCTLG--CENTPGSYHCTCPTGFVLlpDGKQC 401
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
919-947 1.84e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....*....
gi 170172524  919 DIDECQRGaHNCGENAACTNTEGGYNCTC 947
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
919-947 1.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.93e-05
                            10        20
                    ....*....|....*....|....*....
gi 170172524    919 DIDECQRGaHNCGENAACTNTEGGYNCTC 947
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
877-913 2.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 170172524  877 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 913
Cdd:cd00054     1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35
PHA02887 PHA02887
EGF-like protein; Provisional
982-1019 5.52e-05

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 44.15  E-value: 5.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 170172524  982 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:PHA02887   86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
125-156 8.95e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 8.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 170172524    125 VSGLAIDWIDDEVLWVDQQNGVITVTDMTGKN 156
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
414-442 2.68e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 2.68e-04
                           10        20
                   ....*....|....*....|....*....
gi 170172524   414 CSHGCVLTSDGPRCICPAGSVLGRDGKTC 442
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
362-391 2.84e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 2.84e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 170172524   362 DVNECATQNHGCTLG--CENTPGSYHCTCPTG 391
Cdd:pfam07645    1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
383-401 6.70e-04

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 432704  Cd Length: 24  Bit Score: 37.81  E-value: 6.70e-04
                           10
                   ....*....|....*....
gi 170172524   383 SYHCTCPTGFVLLPDGKQC 401
Cdd:pfam12662    1 SYTCSCPPGYTLAGDGRTC 19
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
982-1019 8.35e-04

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 40.78  E-value: 8.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 170172524  982 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:PHA03099   45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
990-1019 2.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.49e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 170172524  990 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 1019
Cdd:cd00054    11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
683-724 2.86e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 2.86e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 170172524    683 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 724
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
86-114 5.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.27e-03
                            10        20
                    ....*....|....*....|....*....
gi 170172524     86 MDIHYKKERLYWVDVERQVLLRVFLNGTG 114
Cdd:smart00135   14 LAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
365-394 7.40e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 7.40e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 170172524  365 ECATqNHGCTLG--CENTPGSYHCTCPTGFVL 394
Cdd:cd00053     1 ECAA-SNPCSNGgtCVNTPGSYRCVCPPGYTG 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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