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Conserved domains on  [gi|46275824|ref|NP_034582|]
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homeobox protein Hox-A3 [Mus musculus]

Protein Classification

homeodomain and DUF4074 domain-containing protein( domain architecture ID 13432639)

protein containing domains COG5576, homeodomain, and DUF4074

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
193-249 7.19e-29

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 7.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46275824   193 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 249
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DUF4074 super family cl16213
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 378-441 5.07e-19

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


The actual alignment was detected with superfamily member pfam13293:

Pssm-ID: 463833  Cd Length: 63  Bit Score: 80.67  E-value: 5.07e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46275824   378 NSGP-LFGLTHLPHTTSAAMDYGGTGPLGSGHHHGPGpgEPHPTYTDLTAHHPSQGRIQEAPKLT 441
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPC--DPHPTYTDLSSHHPSQGRIQEAPKLT 63
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
182-309 1.31e-13

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 68.23  E-value: 1.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275824 182 GDKSPPgqASSKRARTayTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSG 261
Cdd:COG5576  45 QDGSSP--PKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGE 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 46275824 262 GQSPSRSPVPPGaggylnsmhslvnSVPYEPQSPPPFSKPPQGAYGLP 309
Cdd:COG5576 121 EEADLAKIGSLS-------------TGQISIIETLEFSRTSYEEGGLQ 155
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
193-249 7.19e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 7.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46275824   193 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 249
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 192-248 1.08e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 1.08e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 46275824    192 SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 248
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 193-251 3.93e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 97.31  E-value: 3.93e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46275824 193 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 251
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 378-441 5.07e-19

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 80.67  E-value: 5.07e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46275824   378 NSGP-LFGLTHLPHTTSAAMDYGGTGPLGSGHHHGPGpgEPHPTYTDLTAHHPSQGRIQEAPKLT 441
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPC--DPHPTYTDLSSHHPSQGRIQEAPKLT 63
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
182-309 1.31e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 68.23  E-value: 1.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275824 182 GDKSPPgqASSKRARTayTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSG 261
Cdd:COG5576  45 QDGSSP--PKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGE 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 46275824 262 GQSPSRSPVPPGaggylnsmhslvnSVPYEPQSPPPFSKPPQGAYGLP 309
Cdd:COG5576 121 EEADLAKIGSLS-------------TGQISIIETLEFSRTSYEEGGLQ 155
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
193-249 7.19e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 107.59  E-value: 7.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46275824   193 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK 249
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 192-248 1.08e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 98.86  E-value: 1.08e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 46275824    192 SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 248
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 193-251 3.93e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 97.31  E-value: 3.93e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46275824 193 KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ 251
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DUF4074 pfam13293
Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox ...
 378-441 5.07e-19

Domain of unknown function (DUF4074); This family is found at the C-terminal of Homeobox proteins in Metazoa.


Pssm-ID: 463833  Cd Length: 63  Bit Score: 80.67  E-value: 5.07e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46275824   378 NSGP-LFGLTHLPHTTSAAMDYGGTGPLGSGHHHGPGpgEPHPTYTDLTAHHPSQGRIQEAPKLT 441
Cdd:pfam13293   1 GSGPsVFGLNHLPHPSSASMDYSGAAQMPPSQHHGPC--DPHPTYTDLSSHHPSQGRIQEAPKLT 63
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
182-309 1.31e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 68.23  E-value: 1.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275824 182 GDKSPPgqASSKRARTayTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSG 261
Cdd:COG5576  45 QDGSSP--PKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGE 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 46275824 262 GQSPSRSPVPPGaggylnsmhslvnSVPYEPQSPPPFSKPPQGAYGLP 309
Cdd:COG5576 121 EEADLAKIGSLS-------------TGQISIIETLEFSRTSYEEGGLQ 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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