NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6754314|ref|NP_034661|]
View 

interleukin-18-binding protein precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Pox_vIL-18BP super family cl23951
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
47-169 5.23e-10

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


The actual alignment was detected with superfamily member PHA03112:

Pssm-ID: 305108  Cd Length: 141  Bit Score: 55.09  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754314    47 CSSWSPAVPTKQyPALDViwPEKEvplNGTLTLSCTACSRFPYFSILYWL-GNGS------FIEHLPGRLKEGHTSREHR 119
Cdd:PHA03112  17 VDSYVDCVKTRD-VNIYI--PTKE---TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCD 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6754314   120 NTSTWLhraLVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKT 169
Cdd:PHA03112  91 NEPRTD---LIVYNVTDEMKFTKLTCVLMDLDGPIKKSIILNNIWDCFNT 137
 
Name Accession Description Interval E-value
PHA03112 PHA03112
IL-18 binding protein; Provisional
47-169 5.23e-10

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 55.09  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754314    47 CSSWSPAVPTKQyPALDViwPEKEvplNGTLTLSCTACSRFPYFSILYWL-GNGS------FIEHLPGRLKEGHTSREHR 119
Cdd:PHA03112  17 VDSYVDCVKTRD-VNIYI--PTKE---TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCD 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6754314   120 NTSTWLhraLVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKT 169
Cdd:PHA03112  91 NEPRTD---LIVYNVTDEMKFTKLTCVLMDLDGPIKKSIILNNIWDCFNT 137
 
Name Accession Description Interval E-value
PHA03112 PHA03112
IL-18 binding protein; Provisional
47-169 5.23e-10

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 55.09  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754314    47 CSSWSPAVPTKQyPALDViwPEKEvplNGTLTLSCTACSRFPYFSILYWL-GNGS------FIEHLPGRLKEGHTSREHR 119
Cdd:PHA03112  17 VDSYVDCVKTRD-VNIYI--PTKE---TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCD 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6754314   120 NTSTWLhraLVLEELSPTLRSTNFSCLFVDPGQVAQYHIILAQLWDGLKT 169
Cdd:PHA03112  91 NEPRTD---LIVYNVTDEMKFTKLTCVLMDLDGPIKKSIILNNIWDCFNT 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH