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Conserved domains on  [gi|117676374|ref|NP_035156|]
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P2X purinoceptor 4 isoform 1 [Mus musculus]

Protein Classification

P2X purinoceptor( domain architecture ID 10467639)

P2X purinoceptor consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
13-361 0e+00

ATP P2X receptor;


:

Pssm-ID: 425914  Cd Length: 360  Bit Score: 676.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   13 FEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVP 92
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLLYRLLQLLILSYIIGWVFIYEKGYQERDTVISSVTTKVKGVAVTNTSELGERVWDVADYVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   93 AQEENSLFIMTNMIVTVNQTQGTCPEIPDKtSICDSDANCTLGSSDTHSSGIGTGRCVPFNASVKTCEVAAWCPVENDAG 172
Cdd:pfam00864  81 PQGENSFFVMTNLIVTPNQTQGTCPEVPDG-KNCTSDSDCKAGEFDPAGNGIQTGRCVPYNGTTKTCEIFGWCPVENDTV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  173 VPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVADAGHSFQEMAVEGGI 252
Cdd:pfam00864 160 PPRPPLLEEAENFTVFIKNSIRFPKFNFSKRNILPTINSTYLKTCTYHPETDPYCPIFRLGDIVEEAGEDFSDLAVKGGV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  253 MGIQIKWDCNLDRAASHCLPRYSFRRLDTRDlEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDI 332
Cdd:pfam00864 240 IGIQINWDCDLDRDASHCKPKYSFRRLDDKE-NNSVSPGYNFRFAKYYKEANGVEKRTLIKAYGIRFDILVFGKAGKFDI 318
                         330       340
                  ....*....|....*....|....*....
gi 117676374  333 IPTMINVGSGLALLGVATVLCDVIVLYCM 361
Cdd:pfam00864 319 IPTIINIGSGLALLGVATVLCDLILLYFL 347
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
13-361 0e+00

ATP P2X receptor;


Pssm-ID: 425914  Cd Length: 360  Bit Score: 676.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   13 FEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVP 92
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLLYRLLQLLILSYIIGWVFIYEKGYQERDTVISSVTTKVKGVAVTNTSELGERVWDVADYVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   93 AQEENSLFIMTNMIVTVNQTQGTCPEIPDKtSICDSDANCTLGSSDTHSSGIGTGRCVPFNASVKTCEVAAWCPVENDAG 172
Cdd:pfam00864  81 PQGENSFFVMTNLIVTPNQTQGTCPEVPDG-KNCTSDSDCKAGEFDPAGNGIQTGRCVPYNGTTKTCEIFGWCPVENDTV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  173 VPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVADAGHSFQEMAVEGGI 252
Cdd:pfam00864 160 PPRPPLLEEAENFTVFIKNSIRFPKFNFSKRNILPTINSTYLKTCTYHPETDPYCPIFRLGDIVEEAGEDFSDLAVKGGV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  253 MGIQIKWDCNLDRAASHCLPRYSFRRLDTRDlEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDI 332
Cdd:pfam00864 240 IGIQINWDCDLDRDASHCKPKYSFRRLDDKE-NNSVSPGYNFRFAKYYKEANGVEKRTLIKAYGIRFDILVFGKAGKFDI 318
                         330       340
                  ....*....|....*....|....*....
gi 117676374  333 IPTMINVGSGLALLGVATVLCDVIVLYCM 361
Cdd:pfam00864 319 IPTIINIGSGLALLGVATVLCDLILLYFL 347
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-361 0e+00

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 660.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374    1 MAG-CCSVLRAFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKAKGVAVTNTSQ 78
Cdd:TIGR00863   1 MARrLAAGLSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYVIGWVFLAEKGYQESDtSPQSSVITKVKGVAVTQTSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   79 LGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTS-ICDSDANCTLGSSDTHSSGIGTGRCVPFNASVK 157
Cdd:TIGR00863  81 LGNRVWDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSVPLaICWSDSDCTAGEAGTHGNGIKTGRCVPFNGTVK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  158 TCEVAAWCPVENDAgVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVA 237
Cdd:TIGR00863 161 TCEIFAWCPVEVDT-VPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  238 DAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTrdLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGI 317
Cdd:TIGR00863 240 EAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDN--KEKNVSPGYNFRFAKYYRDNAGVETRTLLKAYGI 317
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 117676374  318 RFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCM 361
Cdd:TIGR00863 318 RFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFM 361
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
13-361 0e+00

ATP P2X receptor;


Pssm-ID: 425914  Cd Length: 360  Bit Score: 676.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   13 FEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVP 92
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLLYRLLQLLILSYIIGWVFIYEKGYQERDTVISSVTTKVKGVAVTNTSELGERVWDVADYVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   93 AQEENSLFIMTNMIVTVNQTQGTCPEIPDKtSICDSDANCTLGSSDTHSSGIGTGRCVPFNASVKTCEVAAWCPVENDAG 172
Cdd:pfam00864  81 PQGENSFFVMTNLIVTPNQTQGTCPEVPDG-KNCTSDSDCKAGEFDPAGNGIQTGRCVPYNGTTKTCEIFGWCPVENDTV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  173 VPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVADAGHSFQEMAVEGGI 252
Cdd:pfam00864 160 PPRPPLLEEAENFTVFIKNSIRFPKFNFSKRNILPTINSTYLKTCTYHPETDPYCPIFRLGDIVEEAGEDFSDLAVKGGV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  253 MGIQIKWDCNLDRAASHCLPRYSFRRLDTRDlEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDI 332
Cdd:pfam00864 240 IGIQINWDCDLDRDASHCKPKYSFRRLDDKE-NNSVSPGYNFRFAKYYKEANGVEKRTLIKAYGIRFDILVFGKAGKFDI 318
                         330       340
                  ....*....|....*....|....*....
gi 117676374  333 IPTMINVGSGLALLGVATVLCDVIVLYCM 361
Cdd:pfam00864 319 IPTIINIGSGLALLGVATVLCDLILLYFL 347
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-361 0e+00

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 660.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374    1 MAG-CCSVLRAFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKAKGVAVTNTSQ 78
Cdd:TIGR00863   1 MARrLAAGLSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYVIGWVFLAEKGYQESDtSPQSSVITKVKGVAVTQTSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374   79 LGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTS-ICDSDANCTLGSSDTHSSGIGTGRCVPFNASVK 157
Cdd:TIGR00863  81 LGNRVWDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSVPLaICWSDSDCTAGEAGTHGNGIKTGRCVPFNGTVK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  158 TCEVAAWCPVENDAgVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVA 237
Cdd:TIGR00863 161 TCEIFAWCPVEVDT-VPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676374  238 DAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTrdLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGI 317
Cdd:TIGR00863 240 EAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDN--KEKNVSPGYNFRFAKYYRDNAGVETRTLLKAYGI 317
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 117676374  318 RFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCM 361
Cdd:TIGR00863 318 RFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFM 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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