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Conserved domains on  [gi|158517832|ref|NP_035473|]
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protein transport protein Sec61 subunit gamma isoform 1 [Mus musculus]

Protein Classification

preprotein translocase subunit SecE( domain architecture ID 1575)

preprotein translocase subunit SecE is an essential subunit of the Sec protein translocation channel SecYEG and it clamps together the 2 halves of SecY; may contact the channel plug during translocation

CATH:  1.20.5.1030
Gene Ontology:  GO:0043952|GO:0065002|GO:0006605
SCOP:  4005885
TCDB:  3.A.5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
secE super family cl00481
preprotein translocase subunit SecE; Reviewed
 44-100 2.17e-26

preprotein translocase subunit SecE; Reviewed


The actual alignment was detected with superfamily member PTZ00478:

Pssm-ID: 469787  Cd Length: 81  Bit Score: 92.85  E-value: 2.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 158517832  44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 100
Cdd:PTZ00478  24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
 
Name Accession Description Interval E-value
PTZ00478 PTZ00478
Sec superfamily; Provisional
 44-100 2.17e-26

Sec superfamily; Provisional


Pssm-ID: 185656  Cd Length: 81  Bit Score: 92.85  E-value: 2.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 158517832  44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 100
Cdd:PTZ00478  24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
secE_euk_arch TIGR00327
protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes ...
 38-98 3.87e-14

protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes archaeal SEC61-like and eukaryotic SEC61 but not bacterial secE proteins, for which a Pfam pfam00584 (SecE) has been created. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273016  Cd Length: 61  Bit Score: 61.32  E-value: 3.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158517832   38 QFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV 98
Cdd:TIGR00327   1 KLIEAPVEFIKEGTRVLAVCKKPDLEEYLKVAKVTGIGIIIVGIIGYIIKIIAIPIRGVLK 61
SecE pfam00584
SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex ...
 44-97 6.33e-11

SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.


Pssm-ID: 459858  Cd Length: 55  Bit Score: 52.82  E-value: 6.33e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 158517832   44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIH-IPINNII 97
Cdd:pfam00584   1 KKFFKEVKAELKKVTWPTRKELLKYTVVVLVFVVIMGLFLFLVDLGFsILINLLL 55
Sss1 COG2443
Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular ...
 44-89 8.83e-09

Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441984  Cd Length: 63  Bit Score: 47.52  E-value: 8.83e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 158517832  44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 89
Cdd:COG2443   10 KELLKDYKRVLKLARKPDKEEFLQIAKITGLGILLIGLIGFIIYLI 55
 
Name Accession Description Interval E-value
PTZ00478 PTZ00478
Sec superfamily; Provisional
 44-100 2.17e-26

Sec superfamily; Provisional


Pssm-ID: 185656  Cd Length: 81  Bit Score: 92.85  E-value: 2.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 158517832  44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 100
Cdd:PTZ00478  24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
secE_euk_arch TIGR00327
protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes ...
 38-98 3.87e-14

protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes archaeal SEC61-like and eukaryotic SEC61 but not bacterial secE proteins, for which a Pfam pfam00584 (SecE) has been created. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273016  Cd Length: 61  Bit Score: 61.32  E-value: 3.87e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158517832   38 QFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV 98
Cdd:TIGR00327   1 KLIEAPVEFIKEGTRVLAVCKKPDLEEYLKVAKVTGIGIIIVGIIGYIIKIIAIPIRGVLK 61
SecE pfam00584
SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex ...
 44-97 6.33e-11

SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.


Pssm-ID: 459858  Cd Length: 55  Bit Score: 52.82  E-value: 6.33e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 158517832   44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIH-IPINNII 97
Cdd:pfam00584   1 KKFFKEVKAELKKVTWPTRKELLKYTVVVLVFVVIMGLFLFLVDLGFsILINLLL 55
Sss1 COG2443
Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular ...
 44-89 8.83e-09

Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441984  Cd Length: 63  Bit Score: 47.52  E-value: 8.83e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 158517832  44 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 89
Cdd:COG2443   10 KELLKDYKRVLKLARKPDKEEFLQIAKITGLGILLIGLIGFIIYLI 55
secE PRK09400
preprotein translocase subunit SecE; Reviewed
 37-89 2.09e-08

preprotein translocase subunit SecE; Reviewed


Pssm-ID: 236497  Cd Length: 61  Bit Score: 46.38  E-value: 2.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 158517832  37 MQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 89
Cdd:PRK09400   4 NKLQENVKNFLEDYKRVLKVARKPTREEFLLVAKVTGLGILLIGLIGFIIYLI 56
BAR_3_WASP_bdg pfam10456
WASP-binding domain of Sorting nexin protein; The C-terminal region of the Sorting nexin group ...
 23-71 3.27e-03

WASP-binding domain of Sorting nexin protein; The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with family PX, pfam00787.13, and in combination with PX appears to be necessary to bind WASP along with p85 to form a multimeric signalling complex.


Pssm-ID: 313646  Cd Length: 236  Bit Score: 35.14  E-value: 3.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158517832   23 STLSIRH-PTNMDQVMQFVEPSRQFVK---DSIR--------LVKRCTKPDRKEFQKIAMA 71
Cdd:pfam10456  24 LTIEIPEpPLDLQEVEQKVEGFKRFTKkmdDSVKqlltvgneFWKKCTGPFKKEYQKIGSA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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