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Conserved domains on  [gi|1681411738|ref|NP_035734|]
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toll-like receptor 6 precursor [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 7.04e-31

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 118.19  E-value: 7.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  641 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681411738  719 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-302 1.97e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 116
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 117 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 193
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 194 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 273
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1681411738 274 WPRPVEYLNIYNLTITERIDREEFTYSET 302
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 7.65e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 251 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 330
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 331 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 410
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 411 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 488
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1681411738 489 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 531
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-583 5.18e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 5.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1681411738  529 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 583
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 7.04e-31

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 118.19  E-value: 7.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  641 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681411738  719 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-716 5.14e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.03  E-value: 5.14e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681411738 642 FHAFVSYSEHDS-AWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYEL 716
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-302 1.97e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 116
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 117 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 193
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 194 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 273
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1681411738 274 WPRPVEYLNIYNLTITERIDREEFTYSET 302
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 7.65e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 251 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 330
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 331 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 410
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 411 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 488
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1681411738 489 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 531
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
76-133 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681411738  76 SELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-529 4.71e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 4.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLT-HVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHN-----------RIRSLDFHVFLFNQ------ 100
Cdd:PLN00113  126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqip 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 101 -------DLEYLDVSHNRLQN---ISCCPMASLRHLDLSFNDFdVLPVCKEFGNLTKLTFLGLSAAKFRqlDLLPVAHLH 170
Cdd:PLN00113  206 relgqmkSLKWIYLGYNNLSGeipYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 171 LS-CILLDLVSYHIKGGETE-SLQIPNTTVLHLvFHPNSLFSVQVNM-SVNALGHLQLSNIKLNDENCQRL-----MTFL 242
Cdd:PLN00113  283 LQkLISLDLSDNSLSGEIPElVIQLQNLEILHL-FSNNFTGKIPVALtSLPRLQVLQLWSNKFSGEIPKNLgkhnnLTVL 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 243 SELTRgptllNVTLQHIETTwkCSVKlfqffwprpveylNIYNLTITERIDREEFTYSETALKSLmiEHVKNQVFLFSKE 322
Cdd:PLN00113  362 DLSTN-----NLTGEIPEGL--CSSG-------------NLFKLILFSNSLEGEIPKSLGACRSL--RRVRLQDNSFSGE 419

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 323 aLYSVFAEMnikmlsisdtPFIHmvcppspssftFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNglkNFFKVALMTKNM 402
Cdd:PLN00113  420 -LPSEFTKL----------PLVY-----------FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSFGS 474

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 403 SSLETLDVSLNSLnSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPP--KVKVLDL-HNNRIMSIPKDVTHLQALQELN 479
Cdd:PLN00113  475 KRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSckKLVSLDLsHNQLSGQIPASFSEMPVLSQLD 553

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1681411738 480 VASNSLT-DLP-GCGAFSSLSVLVIDHNSV--SHPSEDFFQSCQNirSLTAGNN 529
Cdd:PLN00113  554 LSQNQLSgEIPkNLGNVESLVQVNISHNHLhgSLPSTGAFLAINA--SAVAGNI 605
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-583 5.18e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 5.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1681411738  529 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 583
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 4.69e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.69e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  78 LRVLRLSHNRIRSLDFHVFLFNqdLEYLDVSHNRLQNI-------SCCPmaSLRHLDLSFNdfdvlPVCK 140
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLeelldllSSWP--SLRELDLTGN-----PVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
379-489 2.29e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 379 LQTLILQRNglknffKVALMTKNM-SSLETLDV---SLNSLNSHAydrtcawAESILVLNLSSNMLTG------------ 442
Cdd:PRK15370  264 LQSLDLFHN------KISCLPENLpEELRYLSVydnSIRTLPAHL-------PSGITHLNVQSNSLTAlpetlppglktl 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1681411738 443 --------SVFRCLPPKVKVLDLHNNRIMSIPKdvTHLQALQELNVASNSLTDLP 489
Cdd:PRK15370  331 eagenaltSLPASLPPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLP 383
LRR_8 pfam13855
Leucine rich repeat;
450-505 6.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 6.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 450 PKVKVLDLHNNRIMSIPKDV-THLQALQELNVASNSLTDLPGcGAFS---SLSVLVIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 369-489 5.83e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 369 VFQGCSTLKRLQTLILQRNGL---KNFFKVALMTKNMSSLETLDVSLNSLNShayDRTCAWAE------SILVLNLSSNM 439
Cdd:cd00116   100 VLESLLRSSSLQELKLNNNGLgdrGLRLLAKGLKDLPPALEKLVLGRNRLEG---ASCEALAKalranrDLKELNLANNG 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681411738 440 LTGSVFRCLPP------KVKVLDLHNNRIMS-----IPKDVTHLQALQELNVASNSLTDLP 489
Cdd:cd00116   177 IGDAGIRALAEglkancNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAG 237
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 7.04e-31

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 118.19  E-value: 7.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  641 QFHAFVSYSEHDsaWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKlrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1681411738  719 AHHNLFHEGSDNLILILLEPILQnNIPSRYHKLRALMaQRTYLEWPTEKGKRglFWANLRAS 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-716 5.14e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 82.03  E-value: 5.14e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1681411738 642 FHAFVSYSEHDS-AWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYEL 716
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDEL 76
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-721 2.07e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 78.90  E-value: 2.07e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1681411738 645 FVSYSEHDSAWVKnELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHH 721
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA 77
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-302 1.97e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLTHVPKDLP--PRTKALSLSQNSISELRmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNIS 116
Cdd:COG4886   121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 117 C--CPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLDLLpvAHL-HLSCilLDLVSYHIKgGETESLQI 193
Cdd:COG4886   199 EplGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL--GNLtNLEE--LDLSNNQLT-DLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 194 PNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFF 273
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....*....
gi 1681411738 274 WPRPVEYLNIYNLTITERIDREEFTYSET 302
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
251-531 7.65e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 251 LLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAE 330
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 331 MNIKMLSISDTPFIHmvcppSPSSFTFLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKvALmtKNMSSLETLDV 410
Cdd:COG4886    96 TNLTELDLSGNEELS-----NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPE-PL--GNLTNLKSLDL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 411 SLNSLNShaYDRTCAWAESILVLNLSSNMLT--GSVFRCLPpKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDL 488
Cdd:COG4886   167 SNNQLTD--LPEELGNLTNLKELDLSNNQITdlPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1681411738 489 PGCGAFSSLSVLVIDHNSVSHPSEDFfqSCQNIRSLTAGNNPF 531
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
332-545 8.78e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 8.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 332 NIKMLSISDTPFIHMvcPPSPSSFT---FLNFTQNVFTDsVFQGCSTLKRLQTLILQRNGLKNFFKVAlmtKNMSSLETL 408
Cdd:COG4886   114 NLESLDLSGNQLTDL--PEELANLTnlkELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL---GNLTNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 409 DVSLNSLNShaYDRTCAWAESILVLNLSSNMLT---GSVFRClpPKVKVLDLHNNRIMSIPkDVTHLQALQELNVASNSL 485
Cdd:COG4886   188 DLSNNQITD--LPEPLGNLTNLEELDLSGNQLTdlpEPLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 486 TDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIG 545
Cdd:COG4886   263 TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-263 1.39e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLTHVPKDLPPRT--KALSLSQNSISELrMPDISFLSELRVLRLSHNRIRSLDfhvFLFN-QDLEYLDVSHNRLQNI 115
Cdd:COG4886   190 SNNQITDLPEPLGNLTnlEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP---ELGNlTNLEELDLSNNQLTDL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 116 S-CCPMASLRHLDLSFNDFDVLpvckEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIP 194
Cdd:COG4886   266 PpLANLTNLKTLDLSNNQLTDL----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1681411738 195 NTTVLhLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTW 263
Cdd:COG4886   342 LSLSL-LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR_8 pfam13855
Leucine rich repeat;
76-133 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681411738  76 SELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-529 4.71e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 4.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLT-HVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHN-----------RIRSLDFHVFLFNQ------ 100
Cdd:PLN00113  126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltNLTSLEFLTLASNQlvgqip 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 101 -------DLEYLDVSHNRLQN---ISCCPMASLRHLDLSFNDFdVLPVCKEFGNLTKLTFLGLSAAKFRqlDLLPVAHLH 170
Cdd:PLN00113  206 relgqmkSLKWIYLGYNNLSGeipYEIGGLTSLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 171 LS-CILLDLVSYHIKGGETE-SLQIPNTTVLHLvFHPNSLFSVQVNM-SVNALGHLQLSNIKLNDENCQRL-----MTFL 242
Cdd:PLN00113  283 LQkLISLDLSDNSLSGEIPElVIQLQNLEILHL-FSNNFTGKIPVALtSLPRLQVLQLWSNKFSGEIPKNLgkhnnLTVL 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 243 SELTRgptllNVTLQHIETTwkCSVKlfqffwprpveylNIYNLTITERIDREEFTYSETALKSLmiEHVKNQVFLFSKE 322
Cdd:PLN00113  362 DLSTN-----NLTGEIPEGL--CSSG-------------NLFKLILFSNSLEGEIPKSLGACRSL--RRVRLQDNSFSGE 419

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 323 aLYSVFAEMnikmlsisdtPFIHmvcppspssftFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNglkNFFKVALMTKNM 402
Cdd:PLN00113  420 -LPSEFTKL----------PLVY-----------FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSFGS 474

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 403 SSLETLDVSLNSLnSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPP--KVKVLDL-HNNRIMSIPKDVTHLQALQELN 479
Cdd:PLN00113  475 KRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSckKLVSLDLsHNQLSGQIPASFSEMPVLSQLD 553

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1681411738 480 VASNSLT-DLP-GCGAFSSLSVLVIDHNSV--SHPSEDFFQSCQNirSLTAGNN 529
Cdd:PLN00113  554 LSQNQLSgEIPkNLGNVESLVQVNISHNHLhgSLPSTGAFLAINA--SAVAGNI 605
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-154 2.45e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  55 KALSLSQNsiselrmPDISFLSELRVLRLSHNRIRSLDFHVFLFNQdLEYLDVSHNRLQNI--SCCPMASLRHLDLSFND 132
Cdd:COG4886    99 TELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLpePLGNLTNLKSLDLSNNQ 170

                          90       100
                  ....*....|....*....|..
gi 1681411738 133 FDVLPvcKEFGNLTKLTFLGLS 154
Cdd:COG4886   171 LTDLP--EELGNLTNLKELDLS 190
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-583 5.18e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 5.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1681411738  529 NPFQCTCELRDFVKnigWVAREVVEGWPDSYRCDYPESSKGtALRDFHMSPLSCD 583
Cdd:smart00082   1 NPFICDCELRWLLR---WLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-162 3.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 3.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  28 FSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIrsldfhvFLFNQDLEYLDV 107
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDL 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1681411738 108 SHNRLQNI--SCCPMASLRHLDLSFNDFDVLPvcKEFGNLTKLTFLGLSAAKFRQLD 162
Cdd:COG4886   121 SGNQLTDLpeELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 4.69e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 4.69e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  78 LRVLRLSHNRIRSLDFHVFLFNqdLEYLDVSHNRLQNI-------SCCPmaSLRHLDLSFNdfdvlPVCK 140
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLeelldllSSWP--SLRELDLTGN-----PVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
379-489 2.29e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 379 LQTLILQRNglknffKVALMTKNM-SSLETLDV---SLNSLNSHAydrtcawAESILVLNLSSNMLTG------------ 442
Cdd:PRK15370  264 LQSLDLFHN------KISCLPENLpEELRYLSVydnSIRTLPAHL-------PSGITHLNVQSNSLTAlpetlppglktl 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1681411738 443 --------SVFRCLPPKVKVLDLHNNRIMSIPKdvTHLQALQELNVASNSLTDLP 489
Cdd:PRK15370  331 eagenaltSLPASLPPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLP 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
29-137 4.58e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  29 SNELESMVD---------YSNRN-LTHVPKDLPPRTKALSLSQNSISEL--RMPdisflSELRVLRLSHNRIRSLDFHVf 96
Cdd:PRK15370  208 NNELKSLPEnlqgniktlYANSNqLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL- 281

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1681411738  97 lfNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDFDVLP 137
Cdd:PRK15370  282 --PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 394-505 7.00e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 394 KVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIM-SIPKDVTHL 472
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSF 163

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1681411738 473 QALQELNVASNSLT-DLPG-CGAFSSLSVLVIDHN 505
Cdd:PLN00113  164 SSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASN 198
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 351-529 7.30e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 351 SPSSFTFLNFTQNVFTDSVFQGcsTLKRLQTLILQRNGLKNffKVALMTKNMSSLETLDVSLNSLNSHAyDRTCAWAESI 430
Cdd:PLN00113  116 TSSSLRYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSG--EIPNDIGSFSSLKVLDLGGNVLVGKI-PNSLTNLTSL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 431 LVLNLSSNMLTGSVFRCLPpKVKVLDL----HNNRIMSIPKDVTHLQALQELNVASNSLTDL--PGCGAFSSLSVLVIDH 504
Cdd:PLN00113  191 EFLTLASNQLVGQIPRELG-QMKSLKWiylgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPipSSLGNLKNLQYLFLYQ 269

                         170       180
                  ....*....|....*....|....*
gi 1681411738 505 NSVSHPSEDFFQSCQNIRSLTAGNN 529
Cdd:PLN00113  270 NKLSGPIPPSIFSLQKLISLDLSDN 294
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-137 7.99e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  40 NRNLTHVPKDLPPRTKALSLSQNSISELrmPDiSFLSELRVLRLSHNRIRSLDFhvfLFNQDLEYLDVSHNRLQNISCCP 119
Cdd:PRK15370  313 SNSLTALPETLPPGLKTLEAGENALTSL--PA-SLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENL 386

                          90
                  ....*....|....*...
gi 1681411738 120 MASLRHLDLSFNDFDVLP 137
Cdd:PRK15370  387 PAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
52-112 1.46e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1681411738  52 PRTKALSLSQNSISELRmpDISF--LSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRL 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
377-533 2.36e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 377 KRLQTLILQRNGLKNffkvalMTKNM-SSLETLDVSLNSLNShaydRTCAWAESILVLNLSSNMLTGSVFRcLPPKVKVL 455
Cdd:PRK15370  199 EQITTLILDNNELKS------LPENLqGNIKTLYANSNQLTS----IPATLPDTIQEMELSINRITELPER-LPSALQSL 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1681411738 456 DLHNNRIMSIPKDVThlQALQELNVASNSLTDLPGcGAFSSLSVLVIDHNSVSHPSEDFfqsCQNIRSLTAGNNPFQC 533
Cdd:PRK15370  268 DLFHNKISCLPENLP--EELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
450-505 6.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 6.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 450 PKVKVLDLHNNRIMSIPKDV-THLQALQELNVASNSLTDLPGcGAFS---SLSVLVIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-137 1.18e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  36 VDYSNRNLTHVPKDLPPRTKALSLSQNSISELrmPDiSFLSELRVLRLSHNRIRSLDFH-------VFLFNQ-------- 100
Cdd:PRK15370  246 MELSINRITELPERLPSALQSLDLFHNKISCL--PE-NLPEELRYLSVYDNSIRTLPAHlpsgithLNVQSNsltalpet 322

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1681411738 101 ---DLEYLDVSHNRLqniSCCPMA---SLRHLDLSFNDFDVLP 137
Cdd:PRK15370  323 lppGLKTLEAGENAL---TSLPASlppELQVLDVSKNQITVLP 362
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-160 1.28e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  39 SNRNLTHVPK-DLPPRTKALSLSQNSISelRMPDISFLSELRVLRLSHNRIRSLDF------------------------ 93
Cdd:cd21340    10 NDKNITKIDNlSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKIENlenlvnlkklylggnrisvvegle 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738  94 --------HV----------FLFNQD--------LEYLDVSHNRLQNISCC-PMASLRHLDLSFNDF----DVLPVCKEF 142
Cdd:cd21340    88 nltnleelHIenqrlppgekLTFDPRslaalsnsLRVLNISGNNIDSLEPLaPLRNLEQLDASNNQIsdleELLDLLSSW 167

                         170       180
                  ....*....|....*....|.
gi 1681411738 143 GNLTKLTFLG---LSAAKFRQ 160
Cdd:cd21340   168 PSLRELDLTGnpvCKKPKYRD 188
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 369-489 5.83e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 369 VFQGCSTLKRLQTLILQRNGL---KNFFKVALMTKNMSSLETLDVSLNSLNShayDRTCAWAE------SILVLNLSSNM 439
Cdd:cd00116   100 VLESLLRSSSLQELKLNNNGLgdrGLRLLAKGLKDLPPALEKLVLGRNRLEG---ASCEALAKalranrDLKELNLANNG 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1681411738 440 LTGSVFRCLPP------KVKVLDLHNNRIMS-----IPKDVTHLQALQELNVASNSLTDLP 489
Cdd:cd00116   177 IGDAGIRALAEglkancNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAG 237
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 358-531 2.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 358 LNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNmsSLETLDVSLNSLNSHAYDRTCAwAESILVLNLSS 437
Cdd:PLN00113  313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN--NLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFS 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 438 NMLTGSVFRCLPP--KVKVLDLHNNRIM-SIPKDVTHLQALQELNVASNSLT--------DLPgcgafsSLSVLVIDHNS 506
Cdd:PLN00113  390 NSLEGEIPKSLGAcrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMP------SLQMLSLARNK 463

                         170       180
                  ....*....|....*....|....*
gi 1681411738 507 VSHPSEDFFQScQNIRSLTAGNNPF 531
Cdd:PLN00113  464 FFGGLPDSFGS-KRLENLDLSRNQF 487
PLN03150 PLN03150
hypothetical protein; Provisional
 374-499 5.64e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 5.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1681411738 374 STLKRLQTLILQRNGLKNFFKVALmtKNMSSLETLDVSLNSLNSHAYDrTCAWAESILVLNLSSNMLTGSVfrclPPKVK 453
Cdd:PLN03150  439 SKLRHLQSINLSGNSIRGNIPPSL--GSITSLEVLDLSYNSFNGSIPE-SLGQLTSLRILNLNGNSLSGRV----PAALG 511

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1681411738 454 VLDLHNNRimsipkdvthlqalqeLNVASNS-LTDLPG---CGAFSSLSV 499
Cdd:PLN03150  512 GRLLHRAS----------------FNFTDNAgLCGIPGlraCGPHLSVGA 545
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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