|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
24-1441 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1707.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 24 KKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 99
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 100 KMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 179
Cdd:PTZ00108 81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 180 TASREYKKMFKQTWMDNMGRAGDMELKPFSG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 258
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 259 NSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVD 338
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 339 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 418
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 419 QIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 498
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 499 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 577
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 578 KVSK-NKQEIAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 656
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 657 VDDRKEWLTNFME----DRRQRKllglpedylygqstsyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 732
Cdd:PTZ00108 637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 733 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPL 812
Cdd:PTZ00108 701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 813 ARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYK 892
Cdd:PTZ00108 781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 893 NFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEqVLEpmlNGTEKTPSLITDYREYHTDTTVKFVIKMT 972
Cdd:PTZ00108 861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 973 EEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQAR 1052
Cdd:PTZ00108 937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1053 FILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPT--FNYLLDMPL 1130
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAvsYDYLLSMPI 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1131 WYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVglpgkagkakgkkaqmcadvlp 1210
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1211 sprGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRIEKKQKKEPGAKkqttlPFKPVKKGRKKNPW 1290
Cdd:PTZ00108 1155 ---EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDK-----PDNKKSNSSGSDQE 1226
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1291 SDSESDVSSNESNvdVPPRQKEQRSAAAKAKFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKippKNTKKALKTQGS 1370
Cdd:PTZ00108 1227 DDEEQKTKPKKSS--VKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPS---KRPDGESNGGSK 1301
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153945749 1371 SmsvvdlESDVKDSVPAspgvPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTA-GTKKRAAPKGTKSDS 1441
Cdd:PTZ00108 1302 P------SSPTKKKVKK----RLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASqSSRLLRRPRKKKSDS 1363
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
28-1176 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1666.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 28 SIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYdEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT 107
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 108 IDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 187
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 188 MFKQTWMDNMGRAGDMELKPF-SGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG-STKDVKVFLNGNSLPVKG 265
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCkASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 266 FRSYVDLYLKDKVDEtgNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNK 345
Cdd:PLN03128 241 FQDYVGLYLGPNSRE--DPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 346 GGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLnKK 425
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 426 CSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAE 505
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 506 INNIIKIVGLQYKKNYeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKNKQ 584
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 585 EIAFYSLPEFEEWKSST-PNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEW 663
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLeGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 664 LTNFMEDrrqrkllglpeDYLyGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKV 743
Cdd:PLN03128 637 LNNYEPG-----------TFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 744 AQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDH 823
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 824 TLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELA- 902
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVSt 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 903 --SNQYVINGEVAILDSTTIEISELPIRTWTQTYKEqVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAE 980
Cdd:PLN03128 865 srSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 981 RVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDG 1060
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1061 KIVIENKPKKELIKVLIQRGYDSDPvkawKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDE 1140
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFP----KTAKISETNVVGDRDGEASEEEEASDNELAKSYDYLLGMPISSLTLEKVDE 1099
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 153945749 1141 LCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELE 1176
Cdd:PLN03128 1100 LRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
5-1456 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1501.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 5 PLQPVNENMLMNKKKNEDGKKrlSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINyREVTFVPGLYKIF 84
Cdd:PLN03237 6 PLQESNSANVAAAPAASSGGK--TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKIF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 85 DEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGY 164
Cdd:PLN03237 83 DEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 165 GAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGD-MELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAY 243
Cdd:PLN03237 163 GAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEpVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 244 DIAGST-KDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGG 322
Cdd:PLN03237 243 DIAGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 323 RHVDYVADQIVSKLVDVVKKKNKGGvAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAI 402
Cdd:PLN03237 323 THVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVM 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 403 GCGIVESILNWVKFKAQIQLnKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGV 482
Cdd:PLN03237 402 KSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 483 FPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPS 562
Cdd:PLN03237 481 FPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQYE---SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPS 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 563 LLR-HRFLEEFITPIVKVSK-NKQEIAFYSLPEFEEWKSS-TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKY 639
Cdd:PLN03237 558 LLKvPSFLVEFITPIVKATRrGKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVW 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 640 SGPEDDAAISLAFSKKQVDDRKEWLTNFMedrrqrkllglPEDYLyGQSTSYLTYNDFINKELILFSNSDNERSIPSMVD 719
Cdd:PLN03237 638 EDEQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMVD 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 720 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDS 799
Cdd:PLN03237 706 GLKPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDH 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 800 ASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLL 879
Cdd:PLN03237 786 ASARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLL 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 880 DGEEPLPMLPSYKNFKGTIEELASNQ----YVINGEVAILDSTTIEISELPIRTWTQTYKEqVLEPMLNGTEKTPS-LIT 954
Cdd:PLN03237 866 NGESMEPMHPWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpFIK 944
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 955 DYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKE 1034
Cdd:PLN03237 945 DVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKE 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1035 WLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDS 1114
Cdd:PLN03237 1025 VLLKNLEFELLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKAKSVEAAVAGATDDAAEEEEEIDVSSS 1104
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1115 AAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQvglpgka 1194
Cdd:PLN03237 1105 SGVRGSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEE------- 1177
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1195 gkaKGKKAQMCADVLPSPRGKRVIPQvtVEMKAEAEKKIRKKIKSENVEGT------PAEDGAEPGSLRQRiEKKQKKEP 1268
Cdd:PLN03237 1178 ---AREKLQRAAARGESGAAKKVSRQ--APKKPAPKKTTKKASESETTEETygssamETENVAEVVKPKGR-AGAKKKAP 1251
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1269 GAKKQTTLPFKPVK-KGRKKNPWSDSESDVSSN--ESNVDVPPRQKEQRSAAAKAKFTVDLDSDEDFSGLDEKDEDEDFL 1345
Cdd:PLN03237 1252 AAAKEKEEEDEILDlKDRLAAYNLDSAPAQSAKmeETVKAVPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLK 1331
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1346 ------PLDATPPKAKiPPKNTKKALKTQGSSMSvvDLESDVKDSVPASpGVPAADFPAETEQSKPSKKTVGVKKTATKS 1419
Cdd:PLN03237 1332 kkggrkPAAANKKAAK-PPAAAKKRGPATVQSGQ--KLLTEMLKPAEAI-GISPEKKVRKMRASPFNKKSGSVLGRAATN 1407
|
1450 1460 1470
....*....|....*....|....*....|....*..
gi 153945749 1420 QSSVSTAGTkkraapKGTKSDSALSARVSEKPAPAKA 1456
Cdd:PLN03237 1408 KETESSENV------SGSSSSEKDEIDVSAKPRPQRA 1438
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
79-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 777.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 79 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDPENnVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVT 158
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 159 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSldKDIVALM 238
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 239 VRRAYDIAGSTKDVKVFLNGN-------SLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERG-FQQI 310
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDErsdeektFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 311 SFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFG- 388
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 389 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQIQ-LNKKCSAVKHTKIKGIPKLDDANDAGSRnstECTLILTEGDS 463
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 464 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 543
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 544 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EIAFYSLPEFEEWKSSTPNHK-KWKVKYYKGLGTSTS 620
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 153945749 621 KEAKEYFADMKRHRIQFKYSGPEDDA-AISLAFSKKQVDDRKEWLTNFM 668
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
692-1166 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 574.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 692 LTYNDFINKELILFSNS-DNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HGEMSLMMTII 768
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 769 NLAQNFVgsNNLNLLQPIGQFGTRLhGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYD-DNQRVEPEWYIPIIPMV 847
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 848 LINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEP----LPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEIS 923
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 924 ELPIRTWTQTYKEQVLEPMLNGteKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFD 1003
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1004 HvGCLKKYDTVlDILRDFFELRLKYYGLRKEWLLGMLGAEsSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDS 1083
Cdd:smart00434 316 N-GRPKKYNLK-EILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1084 dpvkawkeaqqkvpdeeeneesdteTSTSDSAAEagptfnYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDL 1163
Cdd:smart00434 393 -------------------------FELSEIQAD------AILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEE 441
|
...
gi 153945749 1164 WKE 1166
Cdd:smart00434 442 WLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
710-1171 |
2.36e-173 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 526.75 E-value: 2.36e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 710 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 865
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 866 FDVREVVNNIRRLLDGEEP-------LPMLPSYKNFkGTIEELAS---------NQYVINGEVAILDS---TTIEISELP 926
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAGireayetgrGRYIIRGKYEIEDDegrNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 927 IRTWTQTYKEQVLEPMlngTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNsMVLFDHVG 1006
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1007 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKID--GKIVIENKPKKELIKVLIQRGYDSD 1084
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1085 pvkawkeaqqkvpdeeeneesdtetstsdsaaeagpTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKS----- 1159
Cdd:cd00187 390 ------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILaseer 433
|
490
....*....|..
gi 153945749 1160 PSDLWKEDLAVF 1171
Cdd:cd00187 434 PKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
712-1168 |
1.90e-160 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 492.07 E-value: 1.90e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 712 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 788
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 789 FGTRLHGGKDsASPRYIFTMLSPLARLLFPPKDDHTLRFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 867
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 868 VREVVNNIRRLLDGEEP-----LPMLPSYKNFKGTIEELA--------SNQYVINGEVAILDSTTIEISELPIRTWTQTY 934
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGikeayktgRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 935 KEQvLEPMLNgtEKTPSLITDYREYhTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVgclKKYDTV 1014
Cdd:pfam00521 236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1015 LDILRDFFELRLKYYGLRKEWLLGMLGAESSKLN------NQARFILEKIDGKIViENKPKKELIKVLiqrgydsdpvka 1088
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSID-RKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1089 wKEAQqkvpdeeeneesdtetstsdsaaeagptFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPS-----DL 1163
Cdd:pfam00521 376 -SEIQ----------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDL 426
|
....*
gi 153945749 1164 WKEDL 1168
Cdd:pfam00521 427 WIEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
76-221 |
4.61e-96 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 305.42 E-value: 4.61e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 76 FVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEK 155
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153945749 156 KVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFS-GEDYTCITFQPD 221
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEkGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
264-416 |
1.18e-88 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 284.56 E-value: 1.18e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 264 KGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKK 343
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153945749 344 NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKF 416
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
40-665 |
5.29e-86 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 294.35 E-value: 5.29e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 40 EHILLRPDTYIGSVELVTQQMWVYDedvgiNYREVTFVPGLYKIFDEILVNAADNKQR-DPKMS-CIRVTIDpeNNVISI 117
Cdd:PHA02569 11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRtNFKFAnKIDVTIK--NNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 118 WNNGKGIP---VVEHKVEKIYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQT-W 193
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCSnG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 194 MDNMgragDMELKPfSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKgFRSYVDLY 273
Cdd:PHA02569 163 AENI----SWSTKP-GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYAKQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 274 LKDKVdetgnslkvIHEQVNprWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKggVAVKAH 353
Cdd:PHA02569 237 GDDTI---------VQENDN--VSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTKA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 354 QVKN--HMWIFVNALIeNPTFDSQTKENMTLQAKSFGSTCQLSEKFI------KAAIGCGIVESILNWVKFKAQIQLNKK 425
Cdd:PHA02569 304 RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakqilkTEAIIMPIIEAALARKLAAEKAAETKA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 426 CSAVKHTKI-KGIPklddANDAGSrnSTECTLILTEGDSAKTLAVSglgVVGRDKYGVFPLRGKILNVREASHKQIMENA 504
Cdd:PHA02569 383 AKKAKKAKVaKHIK----ANLIGK--DAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKNK 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 505 EINNIIKIVGLQYKknyEDEDSLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLL---RHRFLEefiTPIVKVS 580
Cdd:PHA02569 454 ELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFeqgRIRFVK---TPVIIAQ 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 581 KNKQEIAFYSLPEFEEWKSStpnHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEddaAISLAFSKKQvDDR 660
Cdd:PHA02569 524 VGKETKWFYSLDEFEKAKDS---LKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVLPDDWKE---LFEMLFGDDA-DLR 596
|
....*
gi 153945749 661 KEWLT 665
Cdd:PHA02569 597 KDWMS 601
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
696-1176 |
4.34e-79 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 268.85 E-value: 4.34e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 696 DFINKELILFSNSD-NERSIPSMVDGLKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSsYHHGEMSLMMTIINLA 771
Cdd:PHA02592 10 SIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQDAGALMA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 772 QNFvgSNNLNLLQPIGQFGTRLhgGKDSASPRYIFTMLSPLARLLFppKDDHtLRFLYDDNQRVEPEWYIPIIPMVLING 851
Cdd:PHA02592 89 NTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY--KDED-LAPVHEDPEHIPPAFYLPIIPMVLLNG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 852 AEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWT 931
Cdd:PHA02592 162 VSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEIPVKYDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 932 QTYKEqVLEPMLngtEKtpSLITDYREYHTDtTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLfDHVGCLKKY 1011
Cdd:PHA02592 242 ETYVA-VLDPLE---EK--GKIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NENGKLKVY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1012 DTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLiqrgydsdpvKAWKe 1091
Cdd:PHA02592 314 ENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL----------SDNK- 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1092 aqqkvpdeeeneesdtetstsdsaaEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLavf 1171
Cdd:PHA02592 383 -------------------------DFGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEYIKDL--- 434
|
....*
gi 153945749 1172 iEELE 1176
Cdd:PHA02592 435 -EELK 438
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
454-574 |
1.12e-77 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 251.84 E-value: 1.12e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 454 CTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKnyEDEDSLKTLRYG 533
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 153945749 534 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFIT 574
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
572-710 |
5.00e-77 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 250.52 E-value: 5.00e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 572 FITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLA 651
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 153945749 652 FSKKQVDDRKEWLTNFMedrrqrkllglPEDYLYgQSTSYLTYNDFINKELILFSNSDN 710
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-574 |
2.47e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 210.82 E-value: 2.47e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 454 CTLILTEGDSAKTLAVSGLGVVgrdKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYG 533
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFD---LDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 153945749 534 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFIT 574
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
39-666 |
1.34e-56 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 208.80 E-value: 1.34e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 39 LEHILLRPDTYIGSvelvtqqmwvYDEDvginyrevtfvpGLYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpE 111
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLH-A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 112 NNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQ 191
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RD-GKVYRQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 192 TWmDNMGRAGDMEL--KPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNSLPVKgFRS 268
Cdd:PRK05559 146 RF-EGGDPVGPLEVvgTAGKRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSkAFLLPG----LTITLNDERERQT-FHY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 269 yvDLYLKDKVDETGNSLKVIHEQVNPRW---------EVCLTMSERGFQQI-SFVNSIATSKGGRHVDYVADQIVSKLVD 338
Cdd:PRK05559 220 --ENGLKDYLAELNEGKETLPEEFVGSFegeaegeavEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLKAVRE 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 339 VVKKKN--KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENM-TLQAKSFgstcqlSEKFIKAAIG------CGIVES 409
Cdd:PRK05559 298 FAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRF------VSGVVKDAFDlwlnqnPELAEK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 410 ILNWVKFKAQIQLNKKCSAVKHTKIKG---IPKLddaNDAGSRNSTECTLILTEGDSAktlavSGLGVVGRDKY--GVFP 484
Cdd:PRK05559 372 LAEKAIKAAQARLRAAKKVKRKKKTSGpalPGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILP 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 485 LRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 564
Cdd:PRK05559 444 LRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLV 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 565 R--HRFLEEfiTPIVKVSKNKQEIAFYSLPEFEEW-KSSTPNHKKWKVKYYKGLGTSTSKEAKEYF---ADMKRHRIQFk 638
Cdd:PRK05559 520 EagHVYIAL--PPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLGEMNPDQLWETTmdpETRRLVRVTI- 596
|
650 660 670
....*....|....*....|....*....|.
gi 153945749 639 ysgpEDDAAISLAFSK---KQVDDRKEWLTN 666
Cdd:PRK05559 597 ----DDAEETEKLVDMlmgKKAEPRREWIEE 623
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
39-616 |
1.14e-42 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 166.74 E-value: 1.14e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 39 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDp 110
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 111 ENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 190
Cdd:COG0187 65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 191 QTWMDnmGRA-GDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRaydiagstkdvKVFLNGN------SLPV 263
Cdd:COG0187 143 QRFER--GKPvGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLAERLRE-----------LAFLNKGltitltDERE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 264 KGFRSYVDLY---LKDKVDETGNSLKVIHEQV--------NPRWEVCLTMSERGFQQI-SFVNSIATSKGGRHV------ 325
Cdd:COG0187 210 EEPKEETFHYeggIKDFVEYLNEDKEPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrta 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 326 ------DYVadqivsKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEnmtlqaksfgst 390
Cdd:COG0187 290 ltrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT------------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 391 cQLSEKFIKaaigcGIVESILN----------------WVKF------------KAQIQLNKKcSAvkhTKIKGIP-KLD 441
Cdd:COG0187 340 -KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaarKARELVRRK-SA---LESSGLPgKLA 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 442 DANdagSRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEINNIIKIVGL 515
Cdd:COG0187 410 DCS---SKDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEIRDLITALGT 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 516 QYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQEIAFYSLPE 593
Cdd:COG0187 478 GIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAE 551
|
650 660
....*....|....*....|...
gi 153945749 594 FEEWKSSTPNHKKWKVKYYKGLG 616
Cdd:COG0187 552 LDELLKELKGKKKVEIQRYKGLG 574
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
39-616 |
1.29e-35 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 145.24 E-value: 1.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 39 LEHILLRPDTYIGSvelvtqqmwvydedvginyrevTFVPGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDP 110
Cdd:PRK05644 19 LEAVRKRPGMYIGS----------------------TGERGLHHLVYEIVDNSidealagyCDH---------IEVTINE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 111 eNNVISIWNNGKGIPVVEHKVEKIyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETaSREYKKm 188
Cdd:PRK05644 68 -DGSITVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 189 FKQTWMDnmGR-AGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAgstkdvkvFLNgnslpvKGFR 267
Cdd:PRK05644 143 YYQEYER--GVpVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELA--------FLN------KGLK 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 268 -SYVDL-----------Y---LKDKVDETGNSLKVIHEQV--------NPRWEVCLTMSErGFQQ--ISFVNSIATSKGG 322
Cdd:PRK05644 204 iTLTDEregeekeetfhYeggIKEYVEYLNRNKEPLHEEPiyfegekdGIEVEVAMQYND-GYSEniLSFANNINTHEGG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 323 RHVDYVADQIVSKLVDVVKKKNK---------------GGVAVkahqvknhmwifVNALIENPTFDSQTK------ENMT 381
Cdd:PRK05644 283 THEEGFKTALTRVINDYARKNKLlkekddnltgedvreGLTAV------------ISVKHPEPQFEGQTKtklgnsEVRG 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 382 LQAKSFGStcQLSEKF------IKAaigcgIVESILNwvKFKAQI------QLNKKCSAvkhTKIKGIP-KLDDANdagS 448
Cdd:PRK05644 351 IVDSVVSE--ALSEFLeenpnvAKK-----IVEKAIL--AARAREaarkarELTRRKSA---LESSSLPgKLADCS---S 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 449 RNSTECTLILTEGDSAKTLAVSGlgvvgRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKknyeDEDS 526
Cdd:PRK05644 416 KDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG----DDFD 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 527 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------PIVKVSKNKQEIAfYSLPEFEEW 597
Cdd:PRK05644 487 ISKLRYHKIIIMTDADVDGAHIRTLLLTFF---------YRYMRPLIEagyvyiaqpPLYKIKKGGKEYA-YSDEELDEI 556
|
650 660
....*....|....*....|.
gi 153945749 598 KSSTPNH--KKWKVKYYKGLG 616
Cdd:PRK05644 557 LAELKLKgnPKYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
265-425 |
1.05e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 122.34 E-value: 1.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 265 GFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTM---SERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVK 341
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 342 KKN---KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGC-GIVESILNWVKFK 417
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160
|
....*...
gi 153945749 418 AQIQLNKK 425
Cdd:pfam00204 161 AKARLAAR 168
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
711-1072 |
5.58e-27 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 118.66 E-value: 5.58e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSSYH-HGEMSLMMTIINLAqnfvgsNNLNLLQPIGQF 789
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 790 GTRLHGgkDSAS-PRYIFTMLSPLARLLFPPKDDHTLRFLYdDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDV 868
Cdd:PRK09631 93 GNLFTG--DPASaARYIECRLTPLAKEVLYNKEITEYEPSY-DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 869 REVVNNIRRLLDGeEPLPMLPSYKNfkGTIEELasNQYVI-NGEVAI------LDSTTIEISELPIRTWTQTYKEQVLEP 941
Cdd:PRK09631 170 NEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYADgNGKVLVrakietKDEKTIVIREIPFGTTTESLIASIEKA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 942 MLNGTEKTPSlITDYreyhTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHvgcLKKYDTVLDILRdF 1021
Cdd:PRK09631 245 ARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK-F 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 153945749 1022 FELRLKYYgLRKEwllgmLGAESSKLnnqarfiLEKIDGK----IVIENKPKKEL 1072
Cdd:PRK09631 316 HAEHLQKV-LKME-----LELERAKL-------LEKIFAKtleqIFIEERIYKRI 357
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-564 |
6.07e-24 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 98.11 E-value: 6.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 454 CTLILTEGDSAktlavSGLGVVGRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedsLKTLR 531
Cdd:cd03366 1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 153945749 532 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 564
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
104-586 |
4.27e-20 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 97.09 E-value: 4.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 104 IRVTIDPENNViSIWNNGKGIPVVEHKVEKiyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVeTA 181
Cdd:PRK14939 61 ITVTIHADGSV-SVSDNGRGIPTDIHPEEG--VSAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-TI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 182 SREyKKMFKQTWmdNMGRA-------GDMELKpfsGedyTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAgstkdvkv 254
Cdd:PRK14939 137 RRD-GKIHEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRLRELA-------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 255 FLNGNslpVK------------------GFRSYVDlYLkdkvDETGNSL--KVIH---EQVNPRWEVCLTMSErGFQQ-- 309
Cdd:PRK14939 197 FLNSG---VRirlkderdgkeeefhyegGIKAFVE-YL----NRNKTPLhpNIFYfsgEKDGIGVEVALQWND-SYQEnv 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 310 ISFVNSIATSKGGRHV------------DYVADQIVSKlvdvvKKKNK--------GGVAVKAhqVKnhmwifvnalIEN 369
Cdd:PRK14939 268 LCFTNNIPQRDGGTHLagfraaltrtinNYIEKEGLAK-----KAKVSltgddareGLTAVLS--VK----------VPD 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 370 PTFDSQTKENMtlqaksfGStcqlSEkfIKaaigcGIVESILN--WVKF------KAQIQLNKKCSAVKH---------- 431
Cdd:PRK14939 331 PKFSSQTKDKL-------VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaarkarel 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 432 TKIKGIpkLDDAN------DAGSRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQ 499
Cdd:PRK14939 393 TRRKGA--LDIAGlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDrKFqAILPLKGKILNVEKARFDK 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 500 IMENAEINNIIKIVGLQYKKnyeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT----- 574
Cdd:PRK14939 462 MLSSQEIGTLITALGCGIGR---DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFF---------YRQMPELIErghly 529
|
570
....*....|....*.
gi 153945749 575 ----PIVKVSKNKQEI 586
Cdd:PRK14939 530 iaqpPLYKVKKGKQEQ 545
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
265-654 |
8.60e-20 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 96.10 E-value: 8.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 265 GFRSYVDLYLKDKV----DETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSkGGRHVDYVADQIvSKLVDVV 340
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGN 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 341 KKKN---KGG-VAVKAHQVKNHMWIFVNALIENPTFDSQTKEnmtlqaksfgstcQLSEKFIKAaigcgIVESILNWvKF 416
Cdd:PTZ00109 454 IKKNgyfKGNfVNIPGEFIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE-QL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 417 KAQIQLNKKCSAVKHTKIKGIPKLDDANDAG-----SRNS-----------TECT--------LILTEGDSAktlAVSGL 472
Cdd:PTZ00109 515 SEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNqyystilpgklVDCIsddierneLFIVEGESA---AGNAK 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 473 GVVGRDKYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK----------------------- 528
Cdd:PTZ00109 592 QARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkkn 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 529 -----TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQeiafyslpefEEWKSSTPN 603
Cdd:PTZ00109 672 slfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRM----------KQFNVSTKN 741
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 153945749 604 HKKWKVKYYKGLGTSTSKE-AKEYFADMKRHRIQFKYSGPEDDAAISLAFSK 654
Cdd:PTZ00109 742 SKKYIYTWSDEELNVLIKLlNKDYSSKETTRSVEEKGNAPDLDNEYEDEKLD 793
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
712-1088 |
9.91e-20 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 95.84 E-value: 9.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 788 QFGTRlhGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 865
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 866 FDVREVVNNIRRLLDGEE----------PLPMLP-------------SYKNFKGTIeelasnqyVINGEVAI----LDST 918
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIeedsKGRE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 919 TIEISELPIRTWTQTYKEQVLEpMLNgtEKTPSLITDYREYHTDTTVKFVIkmtEEKLAEAERVGLHKVFK---LQSSLT 995
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 996 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesskLNNqarfilekIDGKI-V 1063
Cdd:TIGR01063 324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
|
410 420
....*....|....*....|....*
gi 153945749 1064 IENKPKKELIKVLIQRGYDSDPVKA 1088
Cdd:TIGR01063 389 IRASQNTEEAKTRLVERFSLSEIQA 413
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1431-1518 |
1.27e-19 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 85.19 E-value: 1.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1431 RAAPKGTK------SDSALSARVSEKPAPAKAKNSRKRKPSSSDSSD-SDFERAISKGATSKKAKG--EEQDFPVDLEDT 1501
Cdd:pfam08070 1 KAAPKAAKaadkssSDSDSDAGASKKPAPPKGRKARKRKPSSSSDDSdSDFGKKPSKAVAKKKSKKvsDDDDFSVDLDSE 80
|
90
....*....|....*..
gi 153945749 1502 IAPRAKSDRARKPIKYL 1518
Cdd:pfam08070 81 VAPRARPGRAKKPVKYL 97
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
711-933 |
6.68e-19 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 91.88 E-value: 6.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSSYHHGEMSLMMTIINLAqnfvgsNNLNLLQPIGQFG 790
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 791 TRLHGGKDSASpRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVRE 870
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCE 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 153945749 871 VVNNIRRLLDgEEPLPMLPSYknFKGTIEELASNQ-----YVINGEVAILDSTTIEISELPIRTWTQT 933
Cdd:PRK09630 172 LLEAQIAILN-DQPFTLLPDF--PSGGTMDASEYQdglgsITLRASIDIINDKTLLIKEICPSTTTET 236
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
711-939 |
1.01e-12 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 73.11 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 711 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEmssYH-HGEMSLMMTIINLAQnfvgsNNLnLLQPIGQF 789
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQ---YHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 790 GTRLhGGKDSASPRYIFTMLSPLA-RLLFPPKDdhTLRFLYDDNQRVEPEwYIPI-IPMVLINGAEGIGTGWSCKIPNFD 867
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFNPKT--TEWQLSYDGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPHN 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 868 VREVVNNIRRLLDGEEP--LPMLPSyknfKGTIEELASNQYVINGEVAI------LDSTTIEISELPIRTWTQTYKEQVL 939
Cdd:PRK12758 188 FNELIDASIAYLKGKEFklYPDFPT----GGIIDVSNYNDGERGGRVRVrakiekLDKKTLVITEIPYGTTTSSLIDSIL 263
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
266-378 |
1.03e-11 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 63.05 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 266 FRSYVDLYLKDKVDEtgnslKVIHEQVNP---RWEVCLTMSE----RGFQQISFVNSIATSKGGRHVDYVADQIVSKLvd 338
Cdd:cd00329 1 LKDRLAEILGDKVAD-----KLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 153945749 339 vvkkknkggvavKAHQVKNHMWIFVNALIEN--PTFD-SQTKE 378
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
80-257 |
1.09e-11 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 65.25 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 80 LYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDD 152
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 153 DEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQTWMDNmGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDK 232
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLEVEVK-RD-GKIYRQEFSRG-GPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDF 148
|
170 180
....*....|....*....|....*
gi 153945749 233 DIVAlmvRRAYDIAGSTKDVKVFLN 257
Cdd:cd16928 149 DTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
711-880 |
1.30e-10 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 66.28 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 711 ERSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 864
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170
....*....|....*.
gi 153945749 865 NFDVREVVNNIRRLLD 880
Cdd:PRK05561 186 PHNLREVIDAAIHLID 201
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
711-1003 |
4.49e-10 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 64.74 E-value: 4.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 711 ERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 786
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 787 GQFGTRlhGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 864
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 865 NFDVREVVNNIRRLLDGEE-------------PLP----------MLPSYKNFKG--------TIEELAsnqyviNGEVA 913
Cdd:PRK13979 189 PHNLKEVIDGTLAYIDNNEittkelmnyikgpDLPtggiligkksLLSAYETGEGkvtlraktKIEKLE------NGRLG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 914 ILdsttieISELPIRtwtqTYKEQVLEPMLNGT-----EKTPSLITDYREYHTDTTVKFVI---KMTEEKLAEAERVGLH 985
Cdd:PRK13979 263 IV------ITEFPYR----RNKAKLLQTISEMTadkkhSKALENISDIRDESDRNGIRAVIefkKSADEDVAEKVLKYLY 332
|
330
....*....|....*...
gi 153945749 986 KVFKLQSSLTCNSMVLFD 1003
Cdd:PRK13979 333 KKTDLQCNISFNMVALAD 350
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
712-880 |
1.08e-08 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 60.06 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 788 QFGTRlhGGkDS-ASPRYIFTMLSPLARLLfppkddhtLRFL----------YDDNQRvEPEwYIP-IIPMVLINGAEGI 855
Cdd:COG0188 110 NFGSI--DG-DPaAAMRYTEARLAKIAEEL--------LADIdkdtvdfvpnYDGSEQ-EPT-VLPaRFPNLLVNGSSGI 176
|
170 180
....*....|....*....|....*..
gi 153945749 856 GTGWSCKIP--NfdVREVVNNIRRLLD 880
Cdd:COG0188 177 AVGMATNIPphN--LGEVIDACIALID 201
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
79-186 |
2.46e-08 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 53.53 E-value: 2.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 79 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENNV-ISIWNNGKGIPVVEHKvekiyvpaLIFGQLLTSSnydddekKV 157
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90 100 110
....*....|....*....|....*....|.
gi 153945749 158 TGGRNGYGAKLCNIFSTKF--TVETASREYK 186
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELLggTITVESEPGG 97
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
712-901 |
3.44e-08 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 58.50 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 712 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 787
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 788 QFGTRlhGGkDS-ASPRYIFTMLSPLARLLFPPKDDHTLRFL--YDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 863
Cdd:PRK05560 105 NFGSI--DG-DPaAAMRYTEARMSKIAHELLADIDKETVDFVpnYDGSEQ-EPT-VLPArFPNLLVNGSSGIAVGMATNI 179
|
170 180 190
....*....|....*....|....*....|....*...
gi 153945749 864 PNFDVREVVNNIRRLLDGEEplpmlpsyknfkGTIEEL 901
Cdd:PRK05560 180 PPHNLGEVIDACLALIDNPD------------ITIEEL 205
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
79-179 |
3.34e-07 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 50.34 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 79 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENN--VISIWNNGKGIPvvEHKVEKIYVPaliFGQLltssnyddDEKK 156
Cdd:smart00387 5 RLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
|
90 100
....*....|....*....|...
gi 153945749 157 VTGGRNGYGAKLCNIFSTKFTVE 179
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGE 91
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
1261-1461 |
1.31e-06 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 52.77 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1261 EKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSdSESDVSSNESNVDVPPRQKEQRSAAAKAKFTVDLDSDEDFSGldekDE 1340
Cdd:pfam03546 322 EESESEEETAPAAAVGQAKSVGKGLQGKAAS-APTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESD----SE 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1341 DEDFLPLDATP----PKAKIPPKNTKKALKTQGSSMSvvdlESDVKDSVPASPGVPA-ADFPAETEQSKP-SKKTVGVKK 1414
Cdd:pfam03546 397 EAAATPAQVKAsgktPQAKANPAPTKASSAKGAASAP----GKVVAAAAQAKQGSPAkVKPPARTPQNSAiSVRGQASVP 472
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 153945749 1415 TATKSqssVSTAGTKKRAAPKGTKSDSALSARV---SEKPAPAKAKNSRK 1461
Cdd:pfam03546 473 AVGKA---VATAAQAQKGPVGGPQEEDSESSEEesdSEEEAPAQAKPSGK 519
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
455-555 |
2.30e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.35 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 455 TLILTEGDS-AKTLAvsglGVVGRDKYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKnyededslktlryg 533
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 153945749 534 kIMIMTDQDQDGSHIKGLLINF 555
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| PRK13808 |
PRK13808 |
adenylate kinase; Provisional |
1349-1487 |
2.92e-05 |
|
adenylate kinase; Provisional
Pssm-ID: 172341 [Multi-domain] Cd Length: 333 Bit Score: 47.96 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1349 ATPPKAKIPPKNT--KKALKTQGSSMSVVDLESDVKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKsqssvsTA 1426
Cdd:PRK13808 198 NAKKAAKTPAAKSgaKKASAKAKSAAKKVSKKKAAKTAVSAKKAAKTAAKAAKKAKKTAKKALKKAAKAVKK------AA 271
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153945749 1427 GTKKRAAPKGTKSdsalSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKA 1487
Cdd:PRK13808 272 KKAAKAAAKAAKG----AAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKAKKV 328
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
454-565 |
7.18e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.10 E-value: 7.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 454 CTLILTEGDS-AKTLAVSGlgvvgRDKYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykknyededslktlRY 532
Cdd:cd00188 1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100 110
....*....|....*....|....*....|...
gi 153945749 533 GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 565
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
1236-1490 |
1.44e-03 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 43.14 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1236 KIKSENVEGTPAEdGAEPGSLRqrieKKQKKEPGAKKQTTLPFKPVKKGRKknpwsDSESdvSSNESNVDvpprqKEQRS 1315
Cdd:pfam03546 122 KPLGKNSQVRPAS-TVGKGPSG----KGANPAPPGKAGSAAPLVQVGKKEE-----DSES--SSEESDSE-----GEAPP 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1316 AAAKAKFTVDLDSDEDFSGldekdededflPLDATPPKakiPPKNTKKALKTQGSSMSVVDLESDvKDSVPASPGVPAAD 1395
Cdd:pfam03546 185 AATQAKPSGKILQVRPASG-----------PAKGAAPA---PPQKAGPVATQVKAERSKEDSESS-EESSDSEEEAPAAA 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1396 FPAeteQSKPSKKTVGVKKTATKSqSSVSTAGTKKRAAPKGT----KSDSALSARVSEKPAPAKAKNSRKRKPSSSDSSD 1471
Cdd:pfam03546 250 TPA---QAKPALKTPQTKASPRKG-TPITPTSAKVPPVRVGTpapwKAGTVTSPACASSPAVARGAQRPEEDSSSSEESE 325
|
250
....*....|....*....
gi 153945749 1472 SDFERAISKGATSKKAKGE 1490
Cdd:pfam03546 326 SEEETAPAAAVGQAKSVGK 344
|
|
| PRK13808 |
PRK13808 |
adenylate kinase; Provisional |
1360-1488 |
5.31e-03 |
|
adenylate kinase; Provisional
Pssm-ID: 172341 [Multi-domain] Cd Length: 333 Bit Score: 41.03 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153945749 1360 NTKKALKTQgssmsvvdlesdvkdsvPASPGVPAADFPAETEQSKPSKKT-----VGVKKTATKSQSSVSTAGTKKRAAP 1434
Cdd:PRK13808 198 NAKKAAKTP-----------------AAKSGAKKASAKAKSAAKKVSKKKaaktaVSAKKAAKTAAKAAKKAKKTAKKAL 260
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 153945749 1435 KGTKSDSALSARVSEKPAPAKAKNSRK--RKPSSSDSSDSDFERAISKGATSKKAK 1488
Cdd:PRK13808 261 KKAAKAVKKAAKKAAKAAAKAAKGAAKatKGKAKAKKKAGKKAAAGSKAKATAKAP 316
|
|
| |
