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Conserved domains on  [gi|6755899|ref|NP_035780|]
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translin [Mus musculus]

Protein Classification

translin( domain architecture ID 10201870)

translin is a DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Translin cd14819
Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as ...
 10-216 2.67e-114

Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in drosophila. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


:

Pssm-ID: 271349  Cd Length: 206  Bit Score: 325.26  E-value: 2.67e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQdIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14819   1 LQEELEKEQELREEIREIVRELDQTLREIQAILQRIHSTPSSQ-VPELCESARELIEEVKETLAELAELIPPHQYYKYND 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLH 169
Cdd:cd14819  80 LWRRILQRAVFLIALRHFLETGRLLTLEEVAEILGVPVNLKDGFHLDLEDYLHGLLSLVNELSRLAVNSVTLGDYERPLK 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6755899  170 ISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRG 216
Cdd:cd14819 160 ISAFVKDLHAGFQLLNLKNDSLRKRFDGLKYDVKKVEEVVYDLSLRG 206
 
Name Accession Description Interval E-value
Translin cd14819
Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as ...
 10-216 2.67e-114

Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in drosophila. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271349  Cd Length: 206  Bit Score: 325.26  E-value: 2.67e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQdIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14819   1 LQEELEKEQELREEIREIVRELDQTLREIQAILQRIHSTPSSQ-VPELCESARELIEEVKETLAELAELIPPHQYYKYND 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLH 169
Cdd:cd14819  80 LWRRILQRAVFLIALRHFLETGRLLTLEEVAEILGVPVNLKDGFHLDLEDYLHGLLSLVNELSRLAVNSVTLGDYERPLK 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6755899  170 ISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRG 216
Cdd:cd14819 160 ISAFVKDLHAGFQLLNLKNDSLRKRFDGLKYDVKKVEEVVYDLSLRG 206
Translin pfam01997
Translin family; Members of this family include Translin that interacts with DNA and forms a ...
 19-216 1.41e-88

Translin family; Members of this family include Translin that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen.


Pssm-ID: 460410 [Multi-domain]  Cd Length: 197  Bit Score: 259.75  E-value: 1.41e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899     19 DIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIpkrCLKAR-EHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQR 97
Cdd:pfam01997   1 DRRERIIKISRDITALSKKIIFLLHRVHSTPSALNV---LNPAKiLAIKEAKERLAELAELLSKLNYYRYNRAWSPGLQE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899     98 LVFLAAFVVYLETETLVTREAVTEILGI-EPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINE 176
Cdd:pfam01997  78 YIEALTFAHYLETGTLLTLEEVQEILGVpVNLDRDGFHLTIEDYLLGLFDLTGELMRLAINSVTLGDYERPLKISQFLRD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 6755899    177 LDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRG 216
Cdd:pfam01997 158 LYAGFQLLNLKNDDLRKKLDVLKYSVKKVEDVVYDLSVRG 197
 
Name Accession Description Interval E-value
Translin cd14819
Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as ...
 10-216 2.67e-114

Translin, also known as TB-RBP (testis brain RNA-binding protein); Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in drosophila. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271349  Cd Length: 206  Bit Score: 325.26  E-value: 2.67e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQdIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14819   1 LQEELEKEQELREEIREIVRELDQTLREIQAILQRIHSTPSSQ-VPELCESARELIEEVKETLAELAELIPPHQYYKYND 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLH 169
Cdd:cd14819  80 LWRRILQRAVFLIALRHFLETGRLLTLEEVAEILGVPVNLKDGFHLDLEDYLHGLLSLVNELSRLAVNSVTLGDYERPLK 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6755899  170 ISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRG 216
Cdd:cd14819 160 ISAFVKDLHAGFQLLNLKNDSLRKRFDGLKYDVKKVEEVVYDLSLRG 206
Translin-like cd14805
Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its ...
 10-208 2.46e-101

Translin and translin-associated factor-X (TRAX); Translin (also known as TB-RBP), and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, and oligomeric complexes of TRAX and translin are known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). The Translin-Trax complex enhances the removal of the passenger strand in RNAi and the formation of active RISC. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA as well as DNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity.


Pssm-ID: 271348 [Multi-domain]  Cd Length: 197  Bit Score: 292.09  E-value: 2.46e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   10 LQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTgfQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHE 89
Cdd:cd14805   1 YQGELDAEQDIRERIRKVVRDIEQESKEIIFLLQGIHSGK--GDIEKRCLEAREHLNTVKQKLTSLATELPAEQYYRFHE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   90 HWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLH 169
Cdd:cd14805  79 HWTFGLQRLVFAAAFVVYLETETLVTREEVTEILGIEPDREKGFHLDVEDYLLGVLDLASELSRLCINSVTAGDYDRPLH 158

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6755899  170 ISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEV 208
Cdd:cd14805 159 ISTFINELYSGFRLLNLKNDELRKRYDTLKYDVKKVEEV 197
Translin pfam01997
Translin family; Members of this family include Translin that interacts with DNA and forms a ...
 19-216 1.41e-88

Translin family; Members of this family include Translin that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen.


Pssm-ID: 460410 [Multi-domain]  Cd Length: 197  Bit Score: 259.75  E-value: 1.41e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899     19 DIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIpkrCLKAR-EHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQR 97
Cdd:pfam01997   1 DRRERIIKISRDITALSKKIIFLLHRVHSTPSALNV---LNPAKiLAIKEAKERLAELAELLSKLNYYRYNRAWSPGLQE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899     98 LVFLAAFVVYLETETLVTREAVTEILGI-EPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINE 176
Cdd:pfam01997  78 YIEALTFAHYLETGTLLTLEEVQEILGVpVNLDRDGFHLTIEDYLLGLFDLTGELMRLAINSVTLGDYERPLKISQFLRD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 6755899    177 LDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRG 216
Cdd:pfam01997 158 LYAGFQLLNLKNDDLRKKLDVLKYSVKKVEDVVYDLSVRG 197
TRAX cd14820
Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its ...
 7-211 2.42e-16

Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its binding partner protein Translin and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). TRAX complexed with Translin is possibly involved in dendritic RNA processing and in DNA double-strand break repair as an interacting partner with C1D, an activator of the DNA-dependent protein kinase involved in the repair of DNA-double strand breaks. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271350 [Multi-domain]  Cd Length: 182  Bit Score: 73.75  E-value: 2.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899    7 FVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLqgvHQGtgfqdipkRCLKAREHFSTVKTHLTSLKTKFPAEQYYR 86
Cdd:cd14820   1 FESIRKELDEKDDKRERLIKLSRDITRLSKRAIFAL---HRG--------DLEEAEELLKEARELLEELRELLKEEPDLL 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755899   87 FHehwRFV---LQRLVFLAAFVVYLETETLVTREavtEILGIEPdrekgfhldvEDYLSGVLILASELSRLSVNSVTAGD 163
Cdd:cd14820  70 YS---GAVspaLQEYVEALSFYHFLKEGRLPTPD---EELGVTP----------EDYLLGLADLTGELMRYAIDSLRKGD 133

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6755899  164 YSRPLHISTFINELDSGFRLLNLKN-DSLRKRYDGLKYDVKKVEEVVYD 211
Cdd:cd14820 134 LEEAEKYLEFMEEIYEGLMSFDYPDaLELRKKLDVDRQSLLKEETRCYE 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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