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Conserved domains on  [gi|6756059|ref|NP_035886|]
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mRNA decay activator protein ZFP36 [Mus musculus]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
96-166 1.84e-12

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.00  E-value: 1.84e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6756059   96 YKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLAL 166
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINL 183
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
96-166 1.84e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.00  E-value: 1.84e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6756059   96 YKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLAL 166
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINL 183
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
96-121 1.47e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 49.50  E-value: 1.47e-08
                          10        20
                  ....*....|....*....|....*.
gi 6756059     96 YKTELCRTYSESGRCRYGAKCQFAHG 121
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
133-160 9.05e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.54  E-value: 9.05e-07
                           10        20
                   ....*....|....*....|....*...
gi 6756059     133 KYKTELChKFYLQGRCPYGSRCHFIHNP 160
Cdd:smart00356   1 KYKTELC-KFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
96-166 1.84e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.00  E-value: 1.84e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6756059   96 YKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLAL 166
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINL 183
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
96-176 1.71e-09

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 58.14  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756059   96 YKT--ELCRTYSESGRCRY---GAKCQFA---HGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLALP 167
Cdd:COG5063 226 YKTnpELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMY 305


                ....*....
gi 6756059  168 GQPHVLRQS 176
Cdd:COG5063 306 EEASLGYLD 314
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
96-121 1.47e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 49.50  E-value: 1.47e-08
                          10        20
                  ....*....|....*....|....*.
gi 6756059     96 YKTELCRTYSESGRCRYGAKCQFAHG 121
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
134-160 2.54e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.03  E-value: 2.54e-07
                          10        20
                  ....*....|....*....|....*..
gi 6756059    134 YKTELCHKFYLQGRCPYGSRCHFIHNP 160
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
133-160 9.05e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.54  E-value: 9.05e-07
                           10        20
                   ....*....|....*....|....*...
gi 6756059     133 KYKTELChKFYLQGRCPYGSRCHFIHNP 160
Cdd:smart00356   1 KYKTELC-KFFKRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
95-122 3.61e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 3.61e-06
                           10        20
                   ....*....|....*....|....*...
gi 6756059      95 RYKTELCRTYsESGRCRYGAKCQFAHGL 122
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 141-158 2.41e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.78  E-value: 2.41e-04
                          10
                  ....*....|....*...
gi 6756059    141 KFYLQGRCPYGSRCHFIH 158
Cdd:pfam18345   2 KFFLKGRCRYGDKCRFAH 19
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 101-120 2.57e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 34.70  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|
gi 6756059    101 CRTYSEsGRCRYGAKCQFAH 120
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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