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Conserved domains on  [gi|6756071|ref|NP_035896|]
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zinc finger protein ZFPM2 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 97-207 1.82e-72

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


:

Pssm-ID: 380993  Cd Length: 111  Bit Score: 235.94  E-value: 1.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071    97 WDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYS 176
Cdd:cd19216    1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 6756071   177 KGGQLWCTTTKAISEGEELVAFVVDFDSRLQ 207
Cdd:cd19216   81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 97-207 1.82e-72

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 235.94  E-value: 1.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071    97 WDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYS 176
Cdd:cd19216    1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 6756071   177 KGGQLWCTTTKAISEGEELVAFVVDFDSRLQ 207
Cdd:cd19216   81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 97-207 1.82e-72

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 235.94  E-value: 1.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071    97 WDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYS 176
Cdd:cd19216    1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 6756071   177 KGGQLWCTTTKAISEGEELVAFVVDFDSRLQ 207
Cdd:cd19216   81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 97-204 3.65e-28

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 110.13  E-value: 3.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071    97 WDGPGELEVFQRDG----ERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQV-----------PMVLTAGPKWLLDVT 161
Cdd:cd19201    1 LSLPGELELRKPSQdagrSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVeaqgskggeglLLLTEDSGTWLKLVR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 6756071   162 WQGVEDSkNNCIVYSKGGQLWCTTTKAISEGEELVAFVVDFDS 204
Cdd:cd19201   81 SADDEDE-ANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 97-200 3.62e-22

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 92.54  E-value: 3.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071    97 WDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQ---VPMVLTAGPKWLLDVTwQGVEDSKNNCI 173
Cdd:cd19215    1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEEspaVTLLLVDEDCWLRRLP-LVSTEAEANCT 79

                         90       100
                 ....*....|....*....|....*..
gi 6756071   174 VYSKGGQLWCTTTKAISEGEELVAFVV 200
Cdd:cd19215   80 IYRKGDAIWCKTTKPVPEGELLSAILV 106
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 100-198 3.82e-07

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 48.73  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6756071   100 PGELEVFQRD---GERKIQSRQQLPVGTTWGPFAGK---MDLNNNSLKTKAQvpmvltagpkwlldvtwqgvedsknNCI 173
Cdd:cd10534    2 PAGLELVLSSipeGGLGVFARRTIPAGTRFGPLEGVvnwMRFVRPARNEEEQ-------------------------NLV 56

                         90       100
                 ....*....|....*....|....*
gi 6756071   174 VYSKGGQLWCTTTKAISEGEELVAF 198
Cdd:cd10534   57 AYQHGGQIYFRTTRDIPPGEELLVW 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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