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Conserved domains on  [gi|145966870|ref|NP_036052|]
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annexin A10 isoform 2 [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446050)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity; similar to Mus musculus annexin A9 which may act as a low affinity receptor for acetylcholine; and Arabidopsis thaliana annexins D1 which may act in counteracting oxidative stress and in mediating regulated, targeted secretion of Golgi-derived vesicles during seedling development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 231-296 1.26e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.68  E-value: 1.26e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145966870  231 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 296
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.06  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145966870   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 155-221 3.02e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 3.02e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145966870  155 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 221
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin super family cl02574
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 106-131 3.86e-06

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


The actual alignment was detected with superfamily member smart00335:

Pssm-ID: 413385  Cd Length: 53  Bit Score: 43.16  E-value: 3.86e-06
                           10        20
                   ....*....|....*....|....*.
gi 145966870   106 GTDENCLIEILASRTNGEIFQMREAY 131
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAY 26
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 231-296 1.26e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.68  E-value: 1.26e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145966870  231 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 296
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.06  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145966870   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 155-221 3.02e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 3.02e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145966870  155 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 221
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
248-296 1.48e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.36  E-value: 1.48e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 145966870   248 KTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 296
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 2.13e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145966870    36 NKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-131 3.86e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 43.16  E-value: 3.86e-06
                           10        20
                   ....*....|....*....|....*.
gi 145966870   106 GTDENCLIEILASRTNGEIFQMREAY 131
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAY 26
ANX smart00335
Annexin repeats;
178-221 6.49e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 42.78  E-value: 6.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 145966870   178 ILCNKSYPQLWLVFQEFQNISGQDLVDAIndCYD--GYFQELLVAI 221
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 231-296 1.26e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.68  E-value: 1.26e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145966870  231 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 296
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.06  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145966870   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 155-221 3.02e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 3.02e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145966870  155 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 221
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
248-296 1.48e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.36  E-value: 1.48e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 145966870   248 KTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 296
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 2.13e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145966870    36 NKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-131 3.86e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 43.16  E-value: 3.86e-06
                           10        20
                   ....*....|....*....|....*.
gi 145966870   106 GTDENCLIEILASRTNGEIFQMREAY 131
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAY 26
ANX smart00335
Annexin repeats;
178-221 6.49e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 42.78  E-value: 6.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 145966870   178 ILCNKSYPQLWLVFQEFQNISGQDLVDAIndCYD--GYFQELLVAI 221
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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