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Conserved domains on  [gi|6981284|ref|NP_037001|]
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neuropeptide Y receptor type 5 [Rattus norvegicus]

Protein Classification

7tmA_NPY5R domain-containing protein( domain architecture ID 11607519)

7tmA_NPY5R domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
42-435 4.49e-159

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


:

Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 449.99  E-value: 4.49e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15398   1 YFLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVES 201
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLESLKNKYLCIES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15398 161 WPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSV------------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitrikKR 361
Cdd:cd15398 198 ------------------------------------------------------------------------------KR 199
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15398 200 SRSVFYRLTIVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKSDL 273
 
Name Accession Description Interval E-value
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
42-435 4.49e-159

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 449.99  E-value: 4.49e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15398   1 YFLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVES 201
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLESLKNKYLCIES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15398 161 WPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSV------------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitrikKR 361
Cdd:cd15398 198 ------------------------------------------------------------------------------KR 199
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15398 200 SRSVFYRLTIVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKSDL 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-424 4.61e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 130.50  E-value: 4.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284     58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTS-VLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYyLLHGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    137 IVRYHMIKHPISNNLTAN--HGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCVESWPSDSY-RIAFTI 213
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTprRAKVLILLVWVLALLLSLPPLLFGWTLTVPE-------GNVTVCFIDFPEVLSkPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    214 SLLLVQYILPLVCLTVSHTSVCRsiscglshkenrleeneminltlqpskksrnqaktpstqkwsysFIRKHRRRyskkt 293
Cdd:pfam00001 154 LSSVLGFLLPLLVILVCYTRIIR--------------------------------------------TLRKSASK----- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    294 acvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvKRSITRIKKRSRSVFYRLTILI 373
Cdd:pfam00001 185 ----------------------------------------------------------QKSEERTQRRERKALKTLAVVV 206
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6981284    374 LVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILY 424
Cdd:pfam00001 207 VVFILCWLPYHIVNLLDSLALDCELSRLLDKALSITLWLAYVNSCLNPIIY 257
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
47-173 2.59e-09

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 58.87  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    47 LYTFVSLLGFMGNLLILMAVMKKRnQKTTVNFLIGNLAFSD-ILVVLFcsPFTLTSVLlDQWMFGKAMCHIMPFLQCVSV 125
Cdd:PHA02638 104 FYIIIFILGLFGNAAIIMILFCKK-IKTITDIYIFNLAISDlIFVIDF--PFIIYNEF-DQWIFGDFMCKVISASYYIGF 179
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6981284   126 LVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:PHA02638 180 FSNMFLITLMSIDRYFAILYPISfqKYRTFNIGIILCIISWILSLIITSP 229
YejM COG3083
Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily [Cell wall ...
83-183 3.79e-03

Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225625 [Multi-domain]  Cd Length: 600  Bit Score: 39.72  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   83 LAFSDILVVLFcspfTLTSVLLDQWMFGkamchimpFLQ-CVSVLVSTLILISIAIV-RYHMIKHPISNNLTANHGYFLI 160
Cdd:COG3083  64 LVFALYLLVLF----PLTFIVLSQRLFR--------FLSvILSTAGMTLLLVDSEVFqRFNLHLNPVVWELLVNPEQSEM 131
                        90       100
                ....*....|....*....|...
gi 6981284  161 ATVWTLGFAicsPLPVFhSLVEL 183
Cdd:COG3083 132 SRDWQLLFA---SVPVI-LLLEL 150
 
Name Accession Description Interval E-value
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
42-435 4.49e-159

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 449.99  E-value: 4.49e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15398   1 YFLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVES 201
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLESLKNKYLCIES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15398 161 WPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSV------------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitrikKR 361
Cdd:cd15398 198 ------------------------------------------------------------------------------KR 199
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15398 200 SRSVFYRLTIVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKSDL 273
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
42-435 2.68e-98

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 296.05  E-value: 2.68e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsALLSSKYLCVES 201
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIE---ILPYCGYFCTES 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15203 158 WPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRG---------------------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevKPEESSDAHEMRVkrsitrikKR 361
Cdd:cd15203 204 ---------------------------------------------------------KRTLSSRRRRSEL--------RR 218
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNL-ISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15203 219 KRRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPqIDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
43-435 9.15e-56

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 186.48  E-value: 9.15e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15397   2 FLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLV-ELKETFGSAL--LSSKYLCV 199
Cdd:cd15397  82 MSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTdEPYKNLSHFFapLADKAVCT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVcrsiscglshkenrleeneminltlqpskksrnqaktpstqkwsy 279
Cdd:cd15397 162 ESWPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRI--------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  280 sFIRKHRRRYskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpiCFEVKPEESsdahemrvkrsitRIK 359
Cdd:cd15397 197 -YLRLRRRKD---------------------------------------------MLERRGEYN-------------RRA 217
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  360 KRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15397 218 GHSKRINVMLVSLVAAFALCWLPLNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKKEV 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
42-429 2.28e-51

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 175.12  E-value: 2.28e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15207   1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPlpvfHSLVELKETFGSALLSSKYLCVES 201
Cdd:cd15207  81 GVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIP----QALVLEVKEYQFFRGQTVHICVEF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLvcltvshtsvcrsiscglshkenrleeneMINltlqpskksrnqaktpstqkwSYSF 281
Cdd:cd15207 157 WPSDEYRKAYTTSLFVLCYVAPL-----------------------------LII---------------------AVLY 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 IRKHRRRYSKKTacvlPAPAGPSQGKHLAVPenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitriKKR 361
Cdd:cd15207 187 VRIGYRLWFKPV----PGGGSASREAQAAVS----------------------------------------------KKK 216
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  362 SRsVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRH--FKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd15207 217 VR-VIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNQREvlYVYIYPIAHWLAYFNSCVNPIVYGYFNR 285
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
42-432 8.57e-51

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 173.55  E-value: 8.57e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGsaLLSSKYLCV 199
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEP--GTITIYICT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGlshkenrleeneminltlqpskksrnqaktpstqkwsy 279
Cdd:cd14993 159 EDWPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRR-------------------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  280 sfirkhrrryskktacvlpapagpsqgkhlAVPENPASVRSQlspsskvipgvpicfevkpeesSDAHEMRVKRSITRIk 359
Cdd:cd14993 201 ------------------------------KPPGDRGSANST----------------------SSRRILRSKKKVARM- 227
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  360 krsrsvfyrLTILILVFAVSWMPLHVFHVVTDFND--NLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIK 432
Cdd:cd14993 228 ---------LIVVVVLFALSWLPYYVLSILLDFGPlsSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
45-428 8.16e-48

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 165.61  E-value: 8.16e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCV 123
Cdd:cd15392   4 ILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQyWPFGEFMCPVVNYLQAV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketfGSALLSSKYLCVESWP 203
Cdd:cd15392  84 SVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFE-----DSNASCGQYICTESWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  204 SDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsysfir 283
Cdd:cd15392 159 SDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVV--------------------------------------------- 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  284 khrrrYSKKTacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkPEESSDAHEMRVKRSITRIKKrsr 363
Cdd:cd15392 194 -----WAKRT----------------------------------------------PGEAENNRDQRMAESKRKLVK--- 219
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  364 svfyRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLN 428
Cdd:cd15392 220 ----MMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMN 280
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
48-435 8.29e-48

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 165.76  E-value: 8.29e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd15395   7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSS---KYLCVESWPS 204
Cdd:cd15395  87 SIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTDEPFKNVNVSLDAykgKYVCLDQFPS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTSVcrsiscglshkenrleeneminltlqpskksrnqaktpstqkwsysFIRK 284
Cdd:cd15395 167 DTIRLSYTTCLLVLQYFGPLCFIFICYLKI----------------------------------------------YIRL 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  285 HRRryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeeSSDAHEMRVKRSITRIKKRsrs 364
Cdd:cd15395 201 KRR-------------------------------------------------------NNMMDKMRDNKYRSSETKR--- 222
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981284  365 VFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15395 223 INIMLISIVVAFAVCWLPLNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQRDL 293
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
42-435 2.22e-47

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 164.62  E-value: 2.22e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15396   1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVE---LKETFGSALLSSKYLC 198
Cdd:cd15396  81 SVSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTDepfRNLSSHSDFYKDKVVC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  199 VESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVcrsiscglshkenrleeneminltlqpskksrnqaktpstqkws 278
Cdd:cd15396 161 IEAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKI-------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  279 ysFIRKHRRryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeeSSDAHEMRVKRSITRI 358
Cdd:cd15396 197 --FVCLKKR-------------------------------------------------------NSKIDRMRENESRLSE 219
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  359 KKRSRSVfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15396 220 NKRINTM---LISIVVTFAACWLPLNIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-428 2.11e-46

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 161.30  E-value: 2.11e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsallsSKYLCVES 201
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRrrFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYG---------GYCCCCLC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRsiscglshkenrleeneminltlqpskksrnqaktpstqkwsysF 281
Cdd:cd00637 152 WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFR--------------------------------------------K 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 IRKHRRRyskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdAHEMRVKRSITRIKKR 361
Cdd:cd00637 188 LRRHRRR---------------------------------------------------------IRSSSSNSSRRRRRRR 210
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNliSNRHFKLVYCICHLLGMMSCCLNPILYGFLN 428
Cdd:cd00637 211 ERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPD--PSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
44-435 2.64e-44

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 156.44  E-value: 2.64e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQC 122
Cdd:cd15394   3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLMQP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCVESW 202
Cdd:cd15394  83 VTVYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG-------LDFSICEEFW 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  203 PS-DSYRIAFTISLLLVQYILPLVCLTVSHtsvCRsISCGLSHkenrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15394 156 FGqEKQRLAYACSTLLITYVLPLLAISLSY---LR-ISVKLRN------------------------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhrrryskktaCVLPAPAGPSQGKhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitRIKKR 361
Cdd:cd15394 195 -------------RVVPGSMTQSQAE-------------------------------------------------WDRAR 212
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  362 SRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15394 213 RRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
44-429 4.20e-41

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 147.66  E-value: 4.20e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15399   3 LILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQAL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVF--HSLVELKETFGSAllsskyLCVES 201
Cdd:cd15399  83 AVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFreYSVIEISPDFKIQ------ACSEK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WP--SDSYRIAFTISLLLVQYILPLVCLTVSHTSVcrsiscglshkenrleeneminltlqpskksrnqaktpstqkwsY 279
Cdd:cd15399 157 WPngTLNDGTIYSVSMLLIQYVLPLAIISYAYIRI--------------------------------------------W 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  280 SFIRKHrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfeVKPEESSDAHEMRvKRSITRIk 359
Cdd:cd15399 193 TKLKNH----------------------------------------------------VSPGGGNDHYHQR-RRKTTKM- 218
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  360 krsrsvfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd15399 219 ---------LVCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNN 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
44-435 4.69e-41

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 147.48  E-value: 4.69e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLsskyLCVESWP 203
Cdd:cd15389  83 SVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRS----RCLPSFP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  204 --SDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRsiscglshkenRLEENEMINltlqpskksrnqaktpstqkwsYSF 281
Cdd:cd15389 159 epSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAK-----------KLWLRNAIG----------------------DVT 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 IRKHRRRYSKKtacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvKRSITrikkr 361
Cdd:cd15389 206 TEQYVAQRRKK-----------------------------------------------------------KKTIK----- 221
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  362 srsvfyRLTILILVFAVSWMPLHVFHVVTDFNDnlisNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15389 222 ------MLMLVVLLFAICWLPLNCYHVLLSSHP----IRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
44-234 1.46e-39

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 143.80  E-value: 1.46e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15202   3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLvelkETFGSALLSSKYLCVESWP 203
Cdd:cd15202  83 SVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKL----ETFKYSEDIVRSLCLEDWP 158
                       170       180       190
                ....*....|....*....|....*....|...
gi 6981284  204 S--DSYRIAFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:cd15202 159 EraDLFWKYYDLALFILQYFLPLLVISFAYARV 191
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
47-434 5.23e-37

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 136.77  E-value: 5.23e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15393   6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgSALLSSKYLCVESWPSDS 206
Cdd:cd15393  86 VSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTD---KTNNGVKPFCLPVGPSDD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  207 YRIAFTISLLLVQYILPLVCLTVSHTsvcrsiscglshkenrleeneMINLTLQPSKKSRNQaktpstqkwsysfirkhr 286
Cdd:cd15393 163 WWKIYNLYLVCVQYFVPLVIICYAYT---------------------RIAVKIWGTKAPGNA------------------ 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  287 rryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpEESSDAHemrvkrsitrIKKRSRSVF 366
Cdd:cd15393 204 ------------------------------------------------------QDVRDDE----------ILKNKKKVI 219
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  367 YRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKAD 434
Cdd:cd15393 220 KMLIIVVALFALCWLPLQTYNLLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKRE 287
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-241 8.35e-37

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 136.75  E-value: 8.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15208   3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVEL-KETFGSALLSSkylCVESW 202
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVvPLANKTILLTV---CDERW 159
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCG 241
Cdd:cd15208 160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCR 198
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
44-238 4.07e-36

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 134.05  E-value: 4.07e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15206   3 IIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGsallsskYLCVES 201
Cdd:cd15206  83 SVSVSTFTLVAISLERYFAICHPLKSRVwqTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG-------HKCREV 155
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15206 156 WPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTL 192
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-424 4.61e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 130.50  E-value: 4.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284     58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTS-VLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYyLLHGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    137 IVRYHMIKHPISNNLTAN--HGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCVESWPSDSY-RIAFTI 213
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTprRAKVLILLVWVLALLLSLPPLLFGWTLTVPE-------GNVTVCFIDFPEVLSkPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    214 SLLLVQYILPLVCLTVSHTSVCRsiscglshkenrleeneminltlqpskksrnqaktpstqkwsysFIRKHRRRyskkt 293
Cdd:pfam00001 154 LSSVLGFLLPLLVILVCYTRIIR--------------------------------------------TLRKSASK----- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    294 acvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvKRSITRIKKRSRSVFYRLTILI 373
Cdd:pfam00001 185 ----------------------------------------------------------QKSEERTQRRERKALKTLAVVV 206
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6981284    374 LVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILY 424
Cdd:pfam00001 207 VVFILCWLPYHIVNLLDSLALDCELSRLLDKALSITLWLAYVNSCLNPIIY 257
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
44-435 8.84e-34

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 128.02  E-value: 8.84e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15391   3 LINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAIcSPLPVFHSLVELKETFGSAllssKYLCVESWP 203
Cdd:cd15391  83 SVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSL-SSVQLFAGRTQRYGQYSEG----RVLCGESWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  204 SDSY-RIAFTISLLLVQYILPLVCLTVSHTsvcrsiscglshkenrleeneMINLTLqpskksrnqaktpstqkWsysfi 282
Cdd:cd15391 158 GPDTsRSAYTVFVMLLTYIIPLLILTSTYG---------------------YVGFRL-----------------W----- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  283 rkhrrrysKKTAcvlpapagpsqgkhlavPENPASVRsqlspsskvipgvpicfevkpeessDAHEMRVKRSITRIkkrs 362
Cdd:cd15391 195 --------NRTA-----------------PGNADKGR-------------------------DDMQIKSKRKVIKM---- 220
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  363 rsvfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRH--FKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15391 221 ------LVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPQhtTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
45-246 1.00e-31

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 122.23  E-value: 1.00e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15979   4 ILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLsskyLCVESW 202
Cdd:cd15979  84 VSVSTFSLVAIAIERYSAICNPLQSRVwqTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGH----QCRHAW 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKE 246
Cdd:cd15979 160 PSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKK 203
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
44-432 5.06e-31

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 120.66  E-value: 5.06e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15205   3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQST 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLvELKETFgsaLLSSKYL-CVE 200
Cdd:cd15205  83 AVVTSILTMTCIAVERHQGIVHPLKMKwqYTNRRAFTMLGLVWIVSVIVGSPMLFVQQL-EVKYDF---LYEKRHVcCLE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  201 SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsys 280
Cdd:cd15205 159 RWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYEL------------------------------------------ 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  281 FIRKhrrryskktacvlpapagpsqgkhlavPENPASVRSQlspsskvIPGVPICfevkpeessdahemrvkrSITRIKK 360
Cdd:cd15205 197 WIKK---------------------------RVGDASVLQT-------IHGIEMS------------------KISRKKK 224
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  361 RSRSVfyrLTILILVFAVSWMPLHVFHVVTDFND--NLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIK 432
Cdd:cd15205 225 RAVKM---MVTVVLLFAVCWAPFHVVHMMIEYSNleNKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
47-427 2.04e-29

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 115.86  E-value: 2.04e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15096   6 IFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVelketFGSALLSSKYLCVESWPS 204
Cdd:cd15096  86 ASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVLFLHGVV-----SYGFSSEAYSYCTFLTEV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  205 DSYRIAFTISLLLVQYILPLVcltvshtsvcrsISCGLShkenrleeneminltlqpskksrnqaktpstqkwsysfirk 284
Cdd:cd15096 161 GTAAQTFFTSFFLFSYLIPLT------------LICVLY----------------------------------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  285 hrrryskktACVLpapagpsqgKHLavpenpasvRSQLSPSSKVIPgvpicfevkpeESSDAhemrvKRSITRIkkrsrs 364
Cdd:cd15096 188 ---------MLML---------RRL---------RRQKSPGGRRSA-----------ESQRG-----KRRVTRL------ 218
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  365 vfyrLTILILVFAVSWMPLHVFHVVTDFndNLISNRHFKLVYCI-CHLLGMMSCCLNPILYGFL 427
Cdd:cd15096 219 ----VVVVVVVFAICWLPIHIILLLKYY--GVLPETVLYVVIQIlSNCLAYGNSCVNPILYAFL 276
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
51-427 5.44e-29

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 115.07  E-value: 5.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15095  10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  131 ILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElKETFGSALlsskyLCVESWPSDSYR 208
Cdd:cd15095  90 TLTALSVDRYYAIVHPIRslRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEE-GYWYGPQT-----YCREVWPSKAFQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  209 IAFTISLLLVQYILPLVCltvshTSVCrsiscglshkenrleeneminltlqpskksrnqaktpstqkwsYSFIRKHRRR 288
Cdd:cd15095 164 KAYMIYTVLLTYVIPLAI-----IAVC-------------------------------------------YGLILRRLWR 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  289 YSKKtacvlpapaGPSQGKHLAVpenpasvrsqlspsskvipgvpicfevkpeessdaHEMRVKRSITRIkkrsrsvfyr 368
Cdd:cd15095 196 RSVD---------GNNQSEQLSE-----------------------------------RALRQKRKVTRM---------- 221
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  369 LTILILVFAVSWMPLHVFHVVTDFNDNlisNRHFKLVYCI---CHLLGMMSCCLNPILYGFL 427
Cdd:cd15095 222 VIVVVVLFAICWLPNHVLNLWQRFDPN---FPETYATYALkiaALCLSYANSAVNPFVYAFM 280
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
47-429 1.92e-28

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 113.68  E-value: 1.92e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd14992   6 ALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLvelkETFGSALLSSKYLCVESWP- 203
Cdd:cd14992  86 ASSLTLTAIAFDRYFAIIHPLKprHRQSYTTTVIIIITIWVVSLLLAIPQLYYATT----EVLFSVKNQEKIFCCQIPPv 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  204 -SDSYRIAFTISLLLVQYILPLVCLTVSHTsvcrsiscglshkenrleeneMINLTLQPSKksrnqaktpstqkwsysfi 282
Cdd:cd14992 162 dNKTYEKVYFLLIFVVIFVLPLIVMTLAYA---------------------RISRELWFRK------------------- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  283 rkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvIPGvpicFEVKPEESsdahemrvkrsiTRIKKRS 362
Cdd:cd14992 202 ----------------------------------------------VPG----FSIKEVER------------KRLKCKR 219
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  363 RSVFYRLTILILvFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd14992 220 RVIKMLVCVVVL-FVICWLPFHLFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNN 285
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
43-429 6.67e-28

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 112.00  E-value: 6.67e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15390   2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLvelkETFGSALLSSKYLCVESW 202
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTT----ETYYYYTGSERTVCFIAW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  203 PSDSY---RIAFTISLLLVQYILPLVCLTVSHTSVcrsiscglshkenrleeneminltlqpskksrnqaktpstqkwsy 279
Cdd:cd15390 158 PDGPNslqDFVYNIVLFVVTYFLPLIIMAVAYTRV--------------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  280 sfirkhrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipGVPICFEVKPEESSDAHE--MRVKRSITR 357
Cdd:cd15390 193 ---------------------------------------------------GVELWGSKTIGENTPRQLesVRAKRKVVK 221
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  358 IkkrsrsvfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd15390 222 M----------MIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNK 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
47-427 9.25e-28

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 111.40  E-value: 9.25e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd14971   6 FFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsalLSSKYLCVESWPS 204
Cdd:cd14971  86 ASIFTLVAMSLDRFLAVVYPLRSLhiRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYT-------PGNRTVCSEAWPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkwsysfirk 284
Cdd:cd14971 159 RAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHL---------------------------------------------- 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  285 hrrryskktacvlpapagpsqgkHLAVPENPASVRSQlspsskvipgvpicfevkpeessdahemRVKRSITRIkkrsrs 364
Cdd:cd14971 193 -----------------------WRVAVRPVLSEGSR----------------------------RAKRKVTRL------ 215
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  365 vfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLvYCICHLLGMMSCCLNPILYGFL 427
Cdd:cd14971 216 ----VLVVVVLFAACWGPIHAILLLVALGPFPLTYATYAL-RIWAHCLAYSNSAVNPVLYAFL 273
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
45-233 1.22e-27

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 110.83  E-value: 1.22e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15001   3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALlsskYLCVESW 202
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTV----YHCQKAW 158
                       170       180       190
                ....*....|....*....|....*....|.
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTS 233
Cdd:cd15001 159 PSTLYSRLYVVYLAIVIFFIPLIVMTFAYAR 189
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
45-231 3.01e-27

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 109.96  E-value: 3.01e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15978   4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVelkeTFGSALLSSKYLCVESW 202
Cdd:cd15978  84 VSVSTFNLVAISLERYSAICKPLKSRVwqTKSHALKVIAATWCLSFTIMLPYPIYSNLV----PFTRINNSTGNMCRLLW 159
                       170       180
                ....*....|....*....|....*....
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15978 160 PNDVTQQSWYIFLLLILFLIPGIVMMTAY 188
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-434 1.49e-26

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 108.27  E-value: 1.49e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLIL--MAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15098   6 VFGLIFCLGVLGNSLVItvLARVKPGKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallSSKYLCVESW 202
Cdd:cd15098  86 MLVSIFTLVAMSVDRYIAVVHSRTSSslRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTA------SNQTFCWENW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpSKKSRNqaktpstqkwsysfI 282
Cdd:cd15098 160 PEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHL-----------------------HKKLKN--------------M 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  283 RKHRRRYSKKTACVlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitrikkrs 362
Cdd:cd15098 203 SKKSERSKKKTAQT------------------------------------------------------------------ 216
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  363 rsvfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFkLVYCICHLLGMMSCCLNPILYGFLNNGIKAD 434
Cdd:cd15098 217 ------VLVVVVVFGISWLPHHIIHLWVEFGDFPLTQASF-VLRITAHCLAYANSCVNPIIYAFLSENFRKA 281
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-238 2.04e-25

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 105.05  E-value: 2.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ--WMFGKAMCHIMPFLQCVS 124
Cdd:cd15204   6 VYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQrsWTHGDVLCAVVNYLRTVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallsSKYLCVESWPS 204
Cdd:cd15204  86 LYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQ-------GKIFCGQIWPV 158
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  205 DSYRI--AFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15204 159 DQQAYykAYYLFLFVLEFVLPVLIMTLCYLRIVRKV 194
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
44-234 2.35e-24

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 102.27  E-value: 2.35e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15980   3 FIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKE---TFGSALLSSK-YLCV 199
Cdd:cd15980  83 SVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNyrvVLGSQNKTSPvYWCR 162
                       170       180       190
                ....*....|....*....|....*....|....*
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:cd15980 163 EDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARI 197
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
53-435 2.57e-24

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 102.07  E-value: 2.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd14986  12 VFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYIL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFgsallsskYLCVESWPSDSYRIAFT 212
Cdd:cd14986  92 VSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGV--------HQCWSSFYTPWQRKVYI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  213 ISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpSKKSRNQAKTPSTQkwsysfirkhRRRYSKK 292
Cdd:cd14986 164 TWLATYVFVIPLIILSYCYGRILRTI-----------------------WIRSRQKTDRPIAP----------TAMSCRS 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  293 TACVlpapagpsqgkhlavpenpaSVRSQLSPSSKVipgvpicfevkpeessdahemrvkrsitrikkrsRSVFYRLTIl 372
Cdd:cd14986 211 VSCV--------------------SSRVSLISRAKI----------------------------------KTIKMTLVI- 235
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  373 ILVFAVSWMPLHVFHVVTDFNDNLISNRHfklVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd14986 236 ILAFILCWTPYFIVQLLDVYAGMQQLEND---AYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
44-235 1.06e-22

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 97.13  E-value: 1.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15012   2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELketFGSALLSSKYLCVES 201
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKqlLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEI---LVTQDGQEEEICVLD 158
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  202 WPSDSYRIAFTISlLLVQYILPLVCLTVSHTSVC 235
Cdd:cd15012 159 REMFNSKLYDTIN-FIVWYLIPLLIMTVLYSKIS 191
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
43-432 1.50e-22

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 97.20  E-value: 1.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15981   2 MFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKY---LCV 199
Cdd:cd15981  82 MSVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMVDDYNNSYplySCW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSiscglshkenrleeneminltlqpskksrnqaktpstqkwsy 279
Cdd:cd15981 162 EAWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFK------------------------------------------ 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  280 sfirkhrrryskktacvLPAPAGPSQGKHLAVPENPasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitRIK 359
Cdd:cd15981 200 -----------------LFKSSAPIRGSQGEEEEGR-----------------------------------------RVS 221
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  360 KRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYC--ICHLLGMMSCCLNPILYGFLNNGIK 432
Cdd:cd15981 222 KRKIKVINMLIIVALFFTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYVfpFAHWLAFFNSSVNPIIYGYFNENFR 296
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
42-239 3.78e-22

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 95.74  E-value: 3.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNN-LTANHGYFLIATVWTLGFAICSPlPVF--HSLVElkETFGSAllsskylC 198
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFrLSKRRALILIAFIWLYGLFWALP-PLFgwSSYVP--EGGGTS-------C 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6981284  199 VESWPSDSYR-IAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd14969 151 SVDWYSKDPNsLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLR 192
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
47-236 9.11e-22

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 94.66  E-value: 9.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSV-LLDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd14997   6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMCKLVPFVELTVA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALlsskYLCVEswP 203
Cdd:cd14997  86 HASVLTILAISFERYYAICHPLQAKyvCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPV----AVCRT--P 159
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  204 SDS-YRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd14997 160 ADTfWKVAYILSTIVVFFVVPLAILSGLYSVICR 193
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-433 1.50e-21

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 93.84  E-value: 1.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd16003   7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSlvelketfgSALLSSKYLCVESWP-SDS 206
Cdd:cd16003  87 SIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSK---------TKVMPGRTLCFVAWPgGPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  207 YRIAFTISLLLVQYILPLVCLTVSHTsvcrsiscglshkenrleeneMINLTLqpskksrnqaktpstqkWSYSfirkhr 286
Cdd:cd16003 158 QHFTYHIIVIVLVYCLPLLVMGITYT---------------------IVGITL-----------------WGGE------ 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  287 rryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvIPGvpicfevkpEESSDAHE-MRVKRSITRIkkrsrsv 365
Cdd:cd16003 194 ------------------------------------------IPG---------DTSDKYHEqLRAKRKVVKM------- 215
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  366 fyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKA 433
Cdd:cd16003 216 ---MIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRA 280
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
43-427 1.83e-21

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 93.90  E-value: 1.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsaLLSSKYLCVE 200
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKslRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQ--------EEGGTISCNL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  201 SWPSDS--YRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpsKKSRNQAKTPSTQKws 278
Cdd:cd14970 153 QWPDPPdyWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRL------------------------RSSRNLSTSGAREK-- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  279 ysfiRKHRRRyskktacvlpapagpsqgkhlavpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsITRI 358
Cdd:cd14970 207 ----RRARRK------------------------------------------------------------------VTRL 216
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  359 kkrsrsvfyrLTILILVFAVSWMPLHVFHVV---TDFNDNLIsnrhFKLVYCICHLLGMMSCCLNPILYGFL 427
Cdd:cd14970 217 ----------VLVVVAVFVVCWLPFHVFQIVrllIDPPETLT----VVGVFLFCIALSYANSCLNPILYAFL 274
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-428 1.84e-19

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 87.98  E-value: 1.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETfgsallssKYLCVESWPSDS- 206
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFP-QCFYSTVTMDQG--------RTKCIVAWPGDSg 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  207 --YRIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenrleeneminltlqpskksrnqaktpstqkWSYsfirk 284
Cdd:cd16004 158 gkHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITL--------------------------------------WRS----- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  285 hrrryskktacvlpapagpsqgkhlAVPENPASVRSQlspsskvipgvpicfevkpeessdaHEMRVKRSITRIkkrsrs 364
Cdd:cd16004 195 -------------------------AVPGHQAHGAYH-------------------------RQLQAKKKFVKT------ 218
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  365 vfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLN 428
Cdd:cd16004 219 ----MVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLN 278
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
42-238 3.41e-19

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 86.90  E-value: 3.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15196   1 KVEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsallSSKYLCVE 200
Cdd:cd15196  81 VVGMYASSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVG--------SGVYDCWA 152
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  201 SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15196 153 TFEPPWGLRAYITWFTVAVFVVPLIILAFCYGRICYVV 190
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
43-229 4.43e-19

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 86.46  E-value: 4.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHimpFLQC 122
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCR---FWIA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVST---LILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHslvelkeTFGSALLSSKYL 197
Cdd:cd14967  78 LDVLCCTasiLNLCAISLDRYLAITRPLRyrQLMTKKRALIMIAAVWVYSLLISLPPLVGW-------RDETQPSVVDCE 150
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  198 CvESWPSDSYriafTISLLLVQYILPLVCLTV 229
Cdd:cd14967 151 C-EFTPNKIY----VLVSSVISFFIPLLIMIV 177
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
42-143 7.68e-19

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 86.32  E-value: 7.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd14977   1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQ 80
                        90       100
                ....*....|....*....|..
gi 6981284  122 CVSVLVSTLILISIAIVRYHMI 143
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAA 102
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
50-238 8.11e-19

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 85.88  E-value: 8.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15213   9 LMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPiSNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketFGSALLSskylCVESWPSDSYRI 209
Cdd:cd15213  89 AILLIISVDRYLIIVQR-QDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYE----FPPRAPQ----CVLGYTESPADR 159
                       170       180
                ....*....|....*....|....*....
gi 6981284  210 AFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15213 160 IYVVLLLVAVFFIPFLIMLYSYFCILNTV 188
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
51-269 4.78e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 83.92  E-value: 4.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15083  10 IGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSIN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  131 ILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGFAICSPlPVfhslvelketFG-SALLSSKYLCVESWP---- 203
Cdd:cd15083  90 TLAAIAVDRYLVITRPMKASVRISHRraLIVIAVVWLYSLLWVLP-PL----------FGwSRYVLEGLLTSCSFDylsr 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  204 SDSYRiAFTISLLLVQYILPLVCLTVSHTSVCRSIScglSHKENRLEENEMINLTLQPSKKSRNQA 269
Cdd:cd15083 159 DDANR-SYVICLLIFGFVLPLLIIIYCYSFIFRAVR---RHEKAMKEMAKRFSKSELSSPKARRQA 220
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
47-229 5.91e-18

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 83.86  E-value: 5.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15927   6 LFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN------LTAnhgyFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVE 200
Cdd:cd15927  86 VSVFTLTALSADRYFAIVNPMRKHrsqatrRTL----VTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYPYPQE 161
                       170       180
                ....*....|....*....|....*....
gi 6981284  201 SWPsdSYRIAFTISLLLVQYILPLVCLTV 229
Cdd:cd15927 162 LGP--NYPKIMVLLRFLVYYLIPLLIIGV 188
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
53-238 1.01e-17

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 82.89  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:cd15212  12 LLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVSTLT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  132 LISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSallsskYLCVESWPSDSYRI-- 209
Cdd:cd15212  92 MTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGF------YHCLYVLHSGPSRLga 165
                       170       180
                ....*....|....*....|....*....
gi 6981284  210 AFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15212 166 AYSSVLIVLCYLLPFALMCFCHYNICKTV 194
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
47-236 4.03e-17

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 81.03  E-value: 4.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILmAVMKKRNQKT--TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15097   6 VFSLIFLLGTVGNSLVL-AVLLRSGQSGhnTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI-SNNL-TANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYLCVESW 202
Cdd:cd15097  85 MYASSFTLAAVSVDRYLAIRYPLrSRELrTPRNAVAAIALIWGLSLLFAGPYLSYYDLID---------YANSTVCMPGW 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  203 pSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15097 156 -EEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIK 188
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
44-240 5.90e-17

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 80.78  E-value: 5.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLY-TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15074   2 IIGIYlTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHP-ISNNLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETFGSAllsskylCVES 201
Cdd:cd15074  82 LFGCCSINTLTAISIYRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVA-PLVGWGSYGPEPFGTS-------CSID 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6981284  202 WPSDSYRI---AFTISLLLVQYILPLVCLTVSHTSVCRSISC 240
Cdd:cd15074 154 WTGASASVggmSYIISIFIFCYLLPVLIIVFSYVKIIRKVKS 195
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
43-239 7.16e-17

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 80.60  E-value: 7.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15094   2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVAD-ECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYLCVE 200
Cdd:cd15094  81 INQFTSSFTLTVMSADRYLAVCHPIRSMRyrTPFIAKVVCATTWSISFLVMLPIILYASTVP---------DSGRYSCTI 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6981284  201 SWPSDSY---RIAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15094 152 VWPDSSAvngQKAFTLYTFLLGFAIPLLLISVFYTLVILRLR 193
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
44-239 7.46e-17

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 80.55  E-value: 7.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFV-SLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15073   2 IVAAYLIVaGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMI-KHPISNNLTANHGYFLIATVWTLGFaicsplpvFHSLVELKETFGSALLSSKYLCVES 201
Cdd:cd15073  82 FFGMASIGLLTVVAVDRYLTIcRPDLGRKMTTNTYTVMILLAWTNAF--------FWAAMPLVGWASYALDPTGATCTIN 153
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  202 WP-SDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15073 154 WRkNDSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVK 192
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
53-258 1.22e-16

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 80.13  E-value: 1.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15195  12 VISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFML 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSAllsskYLCVE--SWPSDSYRIA 210
Cdd:cd15195  92 VVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGF-----HQCVDfgSAPTKKQERL 166
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6981284  211 FTISLLLVQYILPLVCLTVSHTsvcrSISCGLSHKENRLEENEMINLT 258
Cdd:cd15195 167 YYFFTMILSFVIPLIITVTCYL----LILFEISKMAKRARDTPISNRR 210
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-238 3.23e-16

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 78.62  E-value: 3.23e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCspfTLTSVLLD---QWMFGKAMCHIMPFLQCVSVLVSTLILIS 134
Cdd:cd15197  17 GNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLIN---VLTDIIWRitvEWRAGDFACKVIRYLQVVVTYASTYVLVA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  135 IAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLvelketfgSALLSSKYLCVESWPSDSYRIAFTIS 214
Cdd:cd15197  94 LSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMLIIFEK--------TGLSNGEVQCWILWPEPWYWKVYMTI 165
                       170       180
                ....*....|....*....|....
gi 6981284  215 LLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15197 166 VAFLVFFIPATIISICYIIIVRTI 189
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
50-177 3.34e-16

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 78.14  E-value: 3.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15064   9 LIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASI 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15064  89 LHLCVIALDRYWAITDAVeyAHKRTPKRAAVMIALVWTLSICISLP-PLF 137
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
42-175 3.93e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 77.69  E-value: 3.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15210   1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHP-ISNNLTANHGYFL-IATVWTLGFAICSPLP 175
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAHPsLYPRIYTRRGLALmIAGTWIFSFGSFLPLW 136
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
51-239 4.44e-16

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 78.25  E-value: 4.44e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15384  10 MFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  131 ILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPV-FHslVELK---ETFGSALLSSKYlcVESWPSDS 206
Cdd:cd15384  90 ITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAViFH--VERGpfvEDFHQCVTYGFY--TAEWQEQL 165
                       170       180       190
                ....*....|....*....|....*....|...
gi 6981284  207 YriafTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15384 166 Y----NMLSLVFMFPIPLVIMVTCYVLIFITLS 194
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
42-238 8.93e-16

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 77.63  E-value: 8.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIsnNLTANHGYFLI----ATVWTLGFAICSPLPVFHSLvelkETFGSALLSSKYL 197
Cdd:cd15124  81 LTSVGVSVFTLTALSADRYKAIVRPM--DIQASNALMKIclkaALIWILSMLLAIPEAVFSDL----HPFYDKSTNKTFV 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6981284  198 CVESWP-SDSYRIAF-TISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15124 155 SCAPYPhSNELHPKIhSMASFLIFYVIPLSIISVYYYFIAKNL 197
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
42-293 1.12e-15

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 77.35  E-value: 1.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTT-VNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL 120
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSP-LPVFHslVELKETFgsallSSKYLCV 199
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPqSFIFH--VESHPCV-----TWFSQCV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  200 --ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTsvcrSISCGLSHKENRLEENEMINLTlqPSKKSRNqaktpstqkw 277
Cdd:cd15382 154 tfNFFPSHDHELAYNIFNMITMYALPLIIIVFCYS----LILCEISRKSKEKKEDVSEKSS--SVRLRRS---------- 217
                       250
                ....*....|....*.
gi 6981284  278 SYSFIRKHRRRYSKKT 293
Cdd:cd15382 218 SVGLLERARSRTLKMT 233
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
53-238 1.24e-15

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 76.80  E-value: 1.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15008  11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSlvelketfgsallSSKYLCVESWPSDSYR-IAF 211
Cdd:cd15008  91 LSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYG-------------SNWGPHCNFFLPDSWDgAAY 157
                       170       180
                ....*....|....*....|....*..
gi 6981284  212 TISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15008 158 AIIHLLVGFLVPSILIILFYQKVIKYI 184
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
45-173 1.66e-15

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 76.00  E-value: 1.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15063   4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15063  84 CTASILNLCAISLDRYLAITRPIRypSLMSTKRAKCLIAGVWVLSFVICFP 134
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
41-174 1.77e-15

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 75.85  E-value: 1.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   41 QYFLIGLYTFVSLLGFmGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPF 119
Cdd:cd15053   1 NYWALFLLLLPLLTVF-GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGgKWYLGPILCDIYIA 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFAICSPL 174
Cdd:cd15053  80 MDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRvlLTIAIVWVVSAAIACPL 136
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
42-248 2.85e-15

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 75.71  E-value: 2.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFTLTSvLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFV-LTLPFWAVY-AADGWVFGSFLCKLVSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSlveLKETFGSALLSSKYLCV 199
Cdd:cd14984  79 TINFYSGILFLACISIDRYLAIVHAVSalRARTLLHGKLTCLGVWALALLLSLPEFIFSQ---VSEENGSSICSYDYPED 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  200 EswpSDSYRIAFTISLLLVQYILPLVCLtvshtSVCRS-ISCGLSHKENR 248
Cdd:cd14984 156 T---ATTWKTLLRLLQNILGFLLPLLVM-----LFCYSrIIRTLLRARNH 197
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
48-238 3.37e-15

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 75.73  E-value: 3.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd15123   7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPI----SNNLTANHGYflIATVWTLGFAICSPLPVFHSLVelkeTFGSALLSSKYLCVESWP 203
Cdd:cd15123  87 SVFTLTVLSADRYRAIVKPLelqtSDAVLKTCCK--AGCVWIVSMLFAIPEAVFSDLY----SFRDPEKNTTFEACAPYP 160
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  204 SDSYRIAFTISLL--LVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15123 161 VSEKILQEIHSLLcfLVFYIIPLSIISVYYFLIARTL 197
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
47-225 3.39e-15

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 75.52  E-value: 3.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLIlMAVM---KKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15002   5 LLGVICLLGFAGNLMV-IGILlnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHP-----ISN-NLTAnhgyfLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYL 197
Cdd:cd15002  84 CMAAKSFTIAVLAKACYMYVVNPtkqvtIKQrRITA-----VVASIWVPACLLPLPQWLFRTVKQ---------SEGVYL 149
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  198 CVE--SWPSDSYRIAFTISLLLVQYILPLV 225
Cdd:cd15002 150 CILciPPLAHEFMSAFVKLYPLFVFCLPLT 179
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
43-232 5.66e-15

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 74.64  E-value: 5.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDilvVLFCS--PFTLTSVLLD-QWMFGKAMCHIMP 118
Cdd:cd14974   2 VSLVLYALIFLLGLPGNgLVIWVAGFKMKRTVNTVWFL--NLALAD---FLFCLflPFLIVYIAMGhHWPFGSVLCKLNS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFgsallSSKY 196
Cdd:cd14974  77 FVISLNMFASVFLLTAISLDRCLLVLHPVwaQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGR-----SCNL 151
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  197 LCVESWPSDSYR-IAFTISLLLVQYILPLVCLTVSHT 232
Cdd:cd14974 152 TCVEDYDLRRSRhKALTVIRFLCGFLLPLLIIAICYS 188
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
43-177 8.08e-15

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 73.84  E-value: 8.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHI---MPF 119
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVwisFDV 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSvlvSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15329  82 LLCTA---SILNLCAISVDRYLVITRPLtyAVKRTPKRMALMIAIVWLLSALISIP-PLF 137
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
45-238 1.30e-14

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 73.88  E-value: 1.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFM---GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCH---IMP 118
Cdd:cd15048   1 IVLAVLISVLILVtviGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKawlVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCV-SVLvsTLILISIAivRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFgsallsSK 195
Cdd:cd15048  81 YTLCTaSAL--TIVLISLD--RYLSVTKAVKYRAkqTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIV------PT 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6981284  196 YLC-VESWpsdsYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15048 151 GDCeVEFF----DHFYFTFITSVLEFFIPFISVSFFNLLIYLNI 190
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
42-173 1.66e-14

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 73.76  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSvLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15079   1 YLLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNS-FYEGWALGPLGCQIYAFLG 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS-NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15079  80 SLSGIGSIWTNAAIAYDRYNVIVKPLNgNPLTRGKALLLILFIWLYALPWALL 132
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
50-182 2.95e-14

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 72.96  E-value: 2.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15403   9 LMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGV 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  130 LILISIAIVRYHMIKHPiSNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVE 182
Cdd:cd15403  89 AILLIISVDRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVE 140
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
47-177 3.50e-14

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 72.41  E-value: 3.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  127 VSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAIcSPLPVF 177
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEypSKMTKRRVAIMLANVWISPALI-SFLPIF 136
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
43-177 7.39e-14

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 71.22  E-value: 7.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15059  82 LFCTASIVNLCAISLDRYWSVTQAVEYNLkrTPRRAKAMIAAVWIISAVISLP-PLF 137
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-429 1.06e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 71.05  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd16002   7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsallsSKYLCVESWP---S 204
Cdd:cd16002  87 SIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMP---------GRVVCYVEWPeheE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTsvcrsiscglshkenrleeneMINLTLQPSKksrnqaktpstqkwsysfirk 284
Cdd:cd16002 158 RKYETVYHVCVTVLIYFLPLLVIGCAYT---------------------VVGITLWASE--------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  285 hrrryskktacvlpapagpsqgkhlavpenpasvrsqlspsskvIPGvpicfevkpEESSDAHEMRVKRsitrikkrsRS 364
Cdd:cd16002 196 --------------------------------------------IPG---------DSSDRYHEQVSAK---------RK 213
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  365 VFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd16002 214 VVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLND 278
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-238 1.84e-13

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 70.75  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15125   6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPIsnNLTANHGYFLIA----TVWTLGFAICSPLPVFHSLVELKETFGSALLSskylCVESW 202
Cdd:cd15125  86 VSVFTLTALSADRYKAIVNPM--DIQTSSAVLRTClkaiAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTA----CIPYP 159
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  203 PSDSYRIAF-TISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15125 160 QTDEMHPKIhSVLIFLVYFLIPLAIISIYYYHIAKTL 196
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
43-238 2.31e-13

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 69.87  E-value: 2.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFW 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPiSNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsallSSKYLCVESW 202
Cdd:cd15404  82 LFVMEGVAILLIISIDRFLIIVQK-QDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIP--------SRAPQCVFGY 152
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15404 153 TTNPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTV 188
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
44-173 2.86e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 69.69  E-value: 2.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQC 122
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPISypSRMTKRRALIMIALVWICSALISFP 134
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
47-227 3.16e-13

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 69.50  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15973   6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFML-SVPFLAASAALQHWPFGSAMCRTVLSVDGINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISnnlTANHGYFLIAT-----VWTLGFAICSPLPVFhslVELKETFGSALlsskyLCVES 201
Cdd:cd15973  85 TSVFCLTVLSVDRYIAVVHPLR---AARYRRPTVAKminicVWILSLLVISPIIIF---ADTATRKGQAV-----ACNLI 153
                       170       180
                ....*....|....*....|....*.
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCL 227
Cdd:cd15973 154 WPHPAWSAAFVIYTFLLGFLLPVLAI 179
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
48-229 3.69e-13

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 69.67  E-value: 3.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVL-LDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15134   7 YGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWqQYPWVFGEVFCKLRAFLSEMSSY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTA--NHGYFLIATVWTLGFAICSPLPVFHSLV--ELKETFGSALLSSkYLCVESW 202
Cdd:cd15134  87 ASVLTITAFSVERYLAICHPLRSHTMSklSRAIRIIIAIWIIAFVCALPFAIQTRIVylEYPPTSGEALEES-AFCAMLN 165
                       170       180
                ....*....|....*....|....*..
gi 6981284  203 PSDSYRIAFTISLLLVqYILPLVCLTV 229
Cdd:cd15134 166 EIPPITPVFQLSTFLF-FIIPMIAIIV 191
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
42-250 3.82e-13

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 69.60  E-value: 3.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLL-ILMAVMKKRNQKTTVNFLIgNLAFSDILVVLfCSPFTLTSVLLDQWM-FGKAMCHIMPF 119
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILaLWVFLRKMKKRSPTTIYMI-NLALADLLFVL-TLPFRIYYYLNGGWWpFGDFLCRLTGL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPI-SNNL-TANHGYFLIATVWTLGFAICSPLPVFHSlvelketfGSALLSSKYL 197
Cdd:cd14982  79 LFYINMYGSILFLTCISVDRYLAVVHPLkSRRLrRKRYAVGVCAGVWILVLVASVPLLLLRS--------TIAKENNSTT 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6981284  198 CVESWP-SDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLE 250
Cdd:cd14982 151 CFEFLSeWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVR 204
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
43-238 3.85e-13

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 69.47  E-value: 3.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15185   2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLL-FLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHslvelkeTFGSALLSSKYLCVESW 202
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFI-------FYETQELFEEFLCSPLY 153
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  203 PSD---SYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15185 154 PEDtedSWKRFHALRMNIFGLALPLLIMVICYTGIIKTL 192
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
53-173 4.44e-13

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 68.85  E-value: 4.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15330  12 LCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6981284  133 ISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15330  92 CAIALDRYWAITDPIDyvNKRTPRRAAVLISLTWLIGFSISIP 134
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
44-238 4.53e-13

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 69.12  E-value: 4.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15092   3 IVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCVES 201
Cdd:cd15092  82 NMFTSTFTLTAMSVDRYVAICHPIKalDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDE-------EIECLVEIP 154
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15092 155 TPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRL 191
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
42-248 4.53e-13

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 69.34  E-value: 4.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLL-DQWMFGKAMCHIMPFL 120
Cdd:cd15160   1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYIL-TLPLWIDYTANhHNWTFGPLSCKVVGFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPIS-NNLTANHGYFLI-ATVWTLGFAICSPLPVFHSLVELKETFGsallsskyLC 198
Cdd:cd15160  80 FYTNIYASIGFLCCIAVDRYLAVVHPLRfRGLRTRRFALKVsASIWVLELGTHSVFLGHDELFRDEPNHT--------LC 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  199 VESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI--SCGLSHKENR 248
Cdd:cd15160 152 YEKYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVrqSPSLEREEKR 203
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-232 5.52e-13

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 69.03  E-value: 5.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15093   6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGL-PFLAASNALRHWPFGSVLCRLVLSVDGINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFgsallsskYLCVESWP- 203
Cdd:cd15093  85 TSIFCLTVMSVDRYLAVVHPIKSArwRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGS--------SACNMQWPe 156
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  204 -SDSYRIAFTISLLLVQYILPLVCLTVSHT 232
Cdd:cd15093 157 pAAAWSAGFIIYTFVLGFLLPLLIICLCYL 186
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
47-174 5.74e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 68.46  E-value: 5.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTL-TSVLLDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15310   6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMC 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNLTANHGY-----FLIATVWTLGFAICSPL 174
Cdd:cd15310  86 TASILNLCAISIDRYTAVVMPVHYQHGTGQSScrrvsLMITAVWVLAFAVSCPL 139
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
47-229 7.97e-13

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 68.92  E-value: 7.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVL-LDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd14979   6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEACT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWtlGFAICSPLPVF--HSLVELKETFGSALLSSKyLCVES 201
Cdd:cd14979  86 YATVLTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIW--LVSILCAIPILflMGIQYLNGPLPGPVPDSA-VCTLV 162
                       170       180
                ....*....|....*....|....*...
gi 6981284  202 WPSDSYRIAFTISlLLVQYILPLVCLTV 229
Cdd:cd14979 163 VDRSTFKYVFQVS-TFIFFVLPMFVISI 189
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-177 8.82e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 68.11  E-value: 8.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAV-MKKRNQKTTvNFLIGNLAFSDILVVLFCSPFT-LTSVLLDQWMFGKAMChimPFLQCVS 124
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAIsLEKRLQNVT-NYFLMSLAIADLLVGLLVMPLSiLTELFGGVWPLPLVLC---LLWVTLD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  125 VLVST---LILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd15052  82 VLFCTasiMHLCTISLDRYMAIRYPLrtRRNKSRTTVFLKIAIVWLISIGISSPIPVL 139
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
47-177 8.86e-13

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 67.84  E-value: 8.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHI---MPFLQCV 123
Cdd:cd15060   6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMwltCDILCCT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  124 SvlvSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15060  86 A---SILNLCAIALDRYWAIHDPINyaQKRTLKRVLLMIVVVWALSALISVP-PLI 137
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
45-249 1.11e-12

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 67.92  E-value: 1.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15121   4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALAD-AAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHP-ISNNL-TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGsallsskyLCVESW 202
Cdd:cd15121  83 MYASIFLITLMSMDRCLAVAKPfLSQKMrTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMK--------LCIPYH 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCG---LSHKENRL 249
Cdd:cd15121 155 PSVGHEAFQYLFETITGFLLPFTAIVTCYSTIGRRLRSArfrRKRRTNRL 204
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
49-177 1.24e-12

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 68.64  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd15005   8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLFCFH 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  128 STLILISIAIVRYHMIKHP--ISNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFP-PVF 138
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
46-176 1.25e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 68.23  E-value: 1.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   46 GLYTFVSLLGFMGNLLILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKaMCHIMPFLQCVS 124
Cdd:cd15057   5 CILYLLVLLTLLGNALVIAAVLRFRHLRSKVtNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMC 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAIcSPLPV 176
Cdd:cd15057  84 STASILNLCVISVDRYWAISSPFRyeRRMTRRRAFIMIAVAWTLSALI-SFIPV 136
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
47-229 1.51e-12

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 67.48  E-value: 1.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15088   6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPFLIHQFAIDgQWYFGEVMCKIITALDANNQ 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallsSKYLCVESWP 203
Cdd:cd15088  85 FTSTYILTAMSVDRYLAVVHPIRSTkyRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPD--------GTTFCYVSLP 156
                       170       180
                ....*....|....*....|....*.
gi 6981284  204 SDSYRIAFTISLLLVQYILPLVCLTV 229
Cdd:cd15088 157 SPDDLYWFTIYHFILGFAVPLVVITV 182
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
50-239 1.53e-12

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 67.65  E-value: 1.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVN-FLIGNLAFSDILVVLFCspFTLTSVllDQWMFGK-----------AMCHIM 117
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPkLLIINLAIADFLMGIYL--LIIAIA--DQYYRGRyaqyseewlrsPPCLLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  118 PFLQCVSVLVSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFaICSPLPVFHSlveLKETFGSALLSSKY 196
Cdd:cd14980  85 CFLVSLSSLMSVLMMLLITLDRYICIVYPFSNkRLSYKSAKIILILGWLFSI-IFAAIPILYS---INQPGDNRLYGYSS 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  197 LCVESWPSDSYRIAFTISLLLVQ----------YILPLVCLTVSHTSVCRSIS 239
Cdd:cd14980 161 ICMPSNVSNPYYRGWLIAYLLLTfiawiiicilYILIFISVRKSRKSARRSSS 213
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
43-238 2.77e-12

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 67.02  E-value: 2.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallsSKYLCVE 200
Cdd:cd14985  82 VNMFASIFLLTCMSVDRYLAIVHPVASRRlrRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENL-------NKTACIM 154
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  201 SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd14985 155 LYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSL 192
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
43-221 4.14e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 65.84  E-value: 4.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETFGSALLSskylcve 200
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKyrTKRSRRLAITMILAVWVISLLITSP-PLVGPSWHGRRGLGSCYYT------- 152
                       170       180
                ....*....|....*....|....*.
gi 6981284  201 swPSDSYRI-----AFTISLLLVQYI 221
Cdd:cd15061 153 --YDKGYRIyssmgSFFLPLLLMLFV 176
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-228 4.66e-12

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 66.08  E-value: 4.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15402   3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLvelkeTFGSALLSSKYlcves 201
Cdd:cd15402  83 SVIGSIFNITGIAINRYCYICHSLKYDklYSDKNSLCYVLLIWVLTVAAIVPNLFVGSL-----QYDPRIYSCTF----- 152
                       170       180
                ....*....|....*....|....*..
gi 6981284  202 wpSDSYRIAFTISLLLVQYILPLVCLT 228
Cdd:cd15402 153 --AQSVSSAYTIAVVFFHFILPIIIVT 177
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
44-173 4.70e-12

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 65.73  E-value: 4.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSP 173
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNLkrTPRRVKAIIVTVWLISAVISFP 134
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
47-227 4.93e-12

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 66.09  E-value: 4.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15970   6 IYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLML-SVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISnnlTANHGYFLIAT-----VWTLGFAICSPLPVFHSLVelkeTFGSALLSSKYLCVEs 201
Cdd:cd15970  85 TSIYCLTVLSIDRYIAVVHPIK---AARYRRPTVAKmvnlgVWVFSILVILPIIIFSNTA----PNSDGSVACNMQMPE- 156
                       170       180
                ....*....|....*....|....*.
gi 6981284  202 wPSDSYRIAFTISLLLVQYILPLVCL 227
Cdd:cd15970 157 -PSQRWLAVFVVYTFLMGFLLPVIAI 181
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
50-228 5.25e-12

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 66.03  E-value: 5.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15400   9 FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLgfAICSPLPVFHslvelketFGSALLSSK-YLCVESWPSDS 206
Cdd:cd15400  89 FNITGIAINRYCYICHSFAYDklYSRWNTLLYVCLIWAL--TVVAIVPNFF--------VGSLEYDPRiYSCTFVQTASS 158
                       170       180
                ....*....|....*....|..
gi 6981284  207 YriaFTISLLLVQYILPLVCLT 228
Cdd:cd15400 159 S---YTIAVVVIHFIVPITVVS 177
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
47-239 5.90e-12

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 66.07  E-value: 5.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRN-QKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15926   6 VYSVVCALGLVGNLLVLYLMKSKQGwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNLTAN--HGYFLIATVWTLGFAICSPLPVFHSlvelketfgSALLSSKYLCVESWP 203
Cdd:cd15926  86 YASVFFLTAMSVARYHSVASALKSKRRRGccSAKWLCVLIWVLAILASLPNAIFST---------TATVSNEELCLVKFP 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6981284  204 SDSYRIAFTISL-----LLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15926 157 DNRGNAQFWLGLyhaqkVLLGFLIPLGIISLCYLLLVRFIT 197
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
43-226 8.60e-12

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 65.48  E-value: 8.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQ 121
Cdd:cd15967   2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLL-YLLTLPFLVVYYLKgRKWIFGQVFCKITRFCF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPlpvfhslvelkETFGSALLSSKYLCV 199
Cdd:cd15967  81 NLNLYGSIGFLTCISVYRYLAIVHPMRvmGRITTTHSVVISALVWLLVVIQSLP-----------DLFFSKTNSNGTKCF 149
                       170       180       190
                ....*....|....*....|....*....|...
gi 6981284  200 ESWPSD------SYRIAFTISLLLVQYILPLVC 226
Cdd:cd15967 150 DTTFNDylesylTYSLGWTVTGFVIPLLIILGC 182
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
49-271 1.04e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 65.47  E-value: 1.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFV-SLLGFMGNLLILMAVMKKRNQKTT-VNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15383   7 TFVlFVLSACSNLAVLWSATRNRRRKLShVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSP-LPVFHSL-VELKETFGSALLSSKYlcVESWPS 204
Cdd:cd15383  87 SSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPqLFLFHTVtATPPVNFTQCATHGSF--PAHWQE 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  205 DSYRiAFTISLLlvqYILPLVCLTVSHTSVCRSISCGLSHKENRLEENemINLTLQPSKKSRNQAKT 271
Cdd:cd15383 165 TLYN-MFTFFCL---FLLPLLIMIFCYTRILLEISRRMKEKKDSAKNE--VALRSSSDNIPKARMRT 225
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
45-265 1.12e-11

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 65.20  E-value: 1.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15386   4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfGSALLSSKYLCVESWP 203
Cdd:cd15386  84 MFASTYMLIMMTVDRYIAVCHPLrTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQ--GSGVLDCWADFGFPWG 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  204 SDSYRIAFTISLllvqYILPLVCLTVSHTSVCRSISCGLSHK-ENRLEENEMINLTLQPSKKS 265
Cdd:cd15386 162 AKAYITWTTLSI----FVLPVAILIVCYSLICYEICKNLKGKtQTSRSEGGGWRTQGMPSRVS 220
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
47-176 1.12e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 64.93  E-value: 1.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFS 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPV 176
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRfnSRTKAMMKIAAVWTISIGISMPIPV 138
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
43-271 1.17e-11

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 65.03  E-value: 1.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLY-TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSD-ILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL 120
Cdd:cd15337   1 YLIGIYiAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDfGFSAVNGFPLKTISSFNKKWIWGKVACELYGFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGfAICSPLPVFhslvelkeTFGSALL------ 192
Cdd:cd15337  81 GGIFGFMSITTLAAISIDRYLVIAKPLeaMKKMTFKRAFIMIIIIWLWS-LLWSIPPFF--------GWGRYVPegfqts 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  193 -SSKYLcVESWPSdsyrIAFTISLLLVQYILPLVCLTVSHTSVCRSIscglshkenRLEENEMINLT--LQPSKKSRNQA 269
Cdd:cd15337 152 cTFDYL-SRDLNN----RLFILGLFIFGFLCPLLIIIFCYVNIIRAV---------RNHEKEMTQTAksGMGKDTEKNDA 217

                ..
gi 6981284  270 KT 271
Cdd:cd15337 218 RK 219
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
51-238 1.23e-11

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 64.58  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15214   9 IAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASML 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  131 ILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVFH-SLVELKETfgsallssKYLCVESWPSDSY 207
Cdd:cd15214  89 TLGAIAIDRYYAVLYPMvyPMKITGNRAVLALVYIWLHSLIGCLP-PLFGwSSLEFDRF--------KWMCVAAWHKEAG 159
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  208 RIAF-TISLLLVQYILPLVC----LTVSHTSVCRSI 238
Cdd:cd15214 160 YTAFwQVWCALLPFVVMLVCygfiFRVARANQCKAF 195
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
42-225 1.54e-11

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 64.60  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLlDQWMFGKAMCHIMPFLQ 121
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTL-PFWAVSVV-KGWIFGTFMCKLVSLLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANH-GYFLIATVWTLGFAIcsPLPVFHSLVELKETFGSALLSSKYLCVE 200
Cdd:cd15178  79 EANFYSGILLLACISVDRYLAIVHATRALTQKRHlVKFVCAGVWLLSLLL--SLPALLNRDAFKPPNSGRTVCYENLGNE 156
                       170       180
                ....*....|....*....|....*
gi 6981284  201 SwpSDSYRIAFTISLLLVQYILPLV 225
Cdd:cd15178 157 S--ADKWRVVLRILRHTLGFLLPLV 179
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
47-227 1.54e-11

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 64.44  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15974   6 IYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGL-PFLATQNAISYWPFGSFLCRLVMTVDGVNQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFhslVELKETFGSallsskylCVESWPS 204
Cdd:cd15974  85 TSIFCLTVMSIDRYLAVVHPIKSTkwRRPRVAKLINATVWTLSFLVVLPVIIF---SDVQPDLNT--------CNISWPE 153
                       170       180
                ....*....|....*....|....*..
gi 6981284  205 --DSYRIAFTISLLLVQYILPL--VCL 227
Cdd:cd15974 154 pvSVWSTAFIIYTAVLGFFGPLlvICL 180
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
47-246 1.96e-11

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 64.18  E-value: 1.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNLTANH--GYFLIATVWTLGFAICSPLPVFhSLVELKETF--GSALLSSKylcves 201
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRtkAFLKIIAVWTISVGISMPIPVF-GLQDDSKVFkeGSCLLADE------ 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6981284  202 wpsdsyriAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKE 246
Cdd:cd15304 159 --------NFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQ 195
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
47-229 2.26e-11

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 63.94  E-value: 2.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL--DQWMFGKAMCHIMPFLQCVS 124
Cdd:cd14995   6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLgpDSWIYGYAGCLLITYLQYLG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSP---LPVFHSLVELKETFGSallsskylCV 199
Cdd:cd14995  86 INASSLSITAFTIERYIAICHPMKAQFicTVSRAKKIICFVWIFTSLYCSPwlfLLDLSIKHYGDDIVVR--------CG 157
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  200 ESWPSDSYRIAFTISLLLVqYILPLVCLTV 229
Cdd:cd14995 158 YKVSRHYYLPIYLADFVLF-YVIPLLLAIV 186
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
53-194 2.36e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 63.76  E-value: 2.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15325  12 LFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSL 91
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  133 ISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAIC--------SPLPVFHSLVELKETFGSALLSS 194
Cdd:cd15325  92 CIISIDRYIGVSYPLRypSIMTERRGLLALLCVWVLSLVISigplfgwkEPAPEDETICQITEEPGYALFSA 163
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
51-182 2.44e-11

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 63.98  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  131 ILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVE 182
Cdd:cd15000  89 ALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRE 140
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
42-239 2.46e-11

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 63.99  E-value: 2.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvLFCSPFTLTSVLLDqWMFGKAMCHIMPFLQ 121
Cdd:cd15176   1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYLCVES 201
Cdd:cd15176  79 TMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRE---------NSDRYRCLPV 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6981284  202 WPSDSYRIA-FTISLL--LVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15176 150 FPPSLVTSAkATIQILevLLGFVLPFLVMVFCYSRVARALS 190
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
53-194 2.48e-11

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 63.78  E-value: 2.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15327  12 LMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSL 91
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  133 ISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAIC--------SPLPVFHSLVELKETFGSALLSS 194
Cdd:cd15327  92 CVISVDRYVGVKHSLKypTIMTERKAGVILVLLWVSSMVISigpllgwkEPPPPDESICSITEEPGYALFSS 163
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
47-177 2.64e-11

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 64.06  E-value: 2.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLIL--MAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd14976   6 VYMVVFTVGLLGNLLVLylLKSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLN 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISN--NLTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd14976  86 MYSSIFFLTALSVTRYIAVARALKHgwIRKAFGAFATTIAIWAAAALAAIPEAIF 140
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
43-227 3.36e-11

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 63.71  E-value: 3.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGL-PFLAIQVALVHWPFGKAICRVVMTVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLI-ATVWTLGFAICSPLpVFHSLVELKETFGSallsskylCVE 200
Cdd:cd15971  81 INQFTSIFCLTVMSIDRYLAVVHPIkSAKWRKPRTAKMInMAVWGVSLLVILPI-MIYAGVQTKHGRSS--------CTI 151
                       170       180       190
                ....*....|....*....|....*....|.
gi 6981284  201 SWPSDS--YRIAFTISLLLVQYILPL--VCL 227
Cdd:cd15971 152 IWPGESsaWYTGFIIYTFILGFFVPLtiICL 182
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
42-248 3.40e-11

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 63.67  E-value: 3.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILmAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15118   1 VATICLHGIVSTLGIVENLLIL-WVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfGSALLSSKYLCV 199
Cdd:cd15118  80 FLNMFVSGFLLAAISLDRCLLVVKPVwaQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKD--GRKLCYYNFALF 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  200 ESWPSD------SYRIAFTISLLLVQYILPLVCLTVSHTSVcrsiSCGLSHKENR 248
Cdd:cd15118 158 SPSPDNnhpickQRQEGLAISKLLLAFLIPLVIIAVSYAVV----SLIIRHRCRR 208
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
44-173 4.18e-11

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 63.04  E-value: 4.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15322   3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSP 173
Cdd:cd15322  83 FCTSSIVHLCAISLDRYWSITQAIEYNLkrTPRRIKCIIFIVWVISAVISFP 134
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
47-248 4.35e-11

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 63.25  E-value: 4.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDILVVLfCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVS 124
Cdd:cd15115   6 VLSLTFLLGVPGNgLVIWVAGLKMKRTVNTIWFL--NLAVADLLCCL-SLPFSIAHLLLNgHWPYGRFLCKLLPSIIVLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICspLPVFHsLVELKETFGSALLSSKYLcvesw 202
Cdd:cd15115  83 MFASVFTLTAISLDRFLLVIKPVwaQNHRSVLLACLLCGCIWILALLLC--LPVFI-YRTTVTDGNHTRCGYDFL----- 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  203 psdsyrIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENR 248
Cdd:cd15115 155 ------VAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQS 194
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
47-177 4.65e-11

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 63.24  E-value: 4.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDILVVLFCsPFTLTSVLLD-QWMFGKAMCHIMPFLQCVS 124
Cdd:cd15116   6 IYSVVFVLGVLGNgLVIFITGFKMKKTVNTVWFL--NLAVADFLFTFFL-PFSIAYTAMDfHWPFGRFMCKLNSFLLFLN 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd15116  83 MFTSVFLLTVISIDRCISVVFPVwsQNHRSVRLASLVSLAVWVVAFFLSSPSFIF 137
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
58-176 4.84e-11

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 62.93  E-value: 4.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:cd15306  17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6981284  137 IVRYHMIKHPISNNLTANHGYFL--IATVWTLGFAICSPLPV 176
Cdd:cd15306  97 LDRYIAIKKPIQASQYNSRATAFikITVVWLISIGIAIPVPI 138
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
42-238 4.89e-11

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 63.19  E-value: 4.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFTLTSVLLD-QWMFGKAMCHIMPFL 120
Cdd:cd15157   1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFV-STLPFRADYYLMGsHWVFGDIACRIMSYS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLpvfhslveLKEtfGSALLSSKYLC 198
Cdd:cd15157  80 LYVNMYCSIYFLTVLSIVRFLAIVHPFKlwKVTSIKYARILCAVIWIFVMAASSPL--------LSK--GTSKYNSQTKC 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6981284  199 VESWPSDSYRIAFTISLLL-VQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15157 150 LDLHPSKIDKLLILNYIVLvVGFILPFCTLSICYILIIKAL 190
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
49-173 6.30e-11

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 62.63  E-value: 6.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15321  14 TFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSS 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6981284  129 TLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15321  94 IVHLCAISLDRYWSVSRAIEYNskRTPRRIKCIILIVWLIAAVISLP 140
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
51-224 7.32e-11

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 62.81  E-value: 7.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15336  10 IGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  131 ILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVW--TLGFAICsPLpvfhslvelketFG-SALLSSKYLCVESW--- 202
Cdd:cd15336  90 TLLAISLDRYLVITKPLAsiRWVSKKRAMIIILLVWlySLAWSLP-PL------------FGwSAYVPEGLLTSCTWdym 156
                       170       180
                ....*....|....*....|...
gi 6981284  203 -PSDSYRiAFTISLLLVQYILPL 224
Cdd:cd15336 157 tFTPSVR-AYTMLLFCFVFFIPL 178
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
43-238 8.13e-11

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 62.48  E-value: 8.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVlLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15175   2 FLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADIL-FLLTLPFWAASA-AKKWVFGEEMCKAVYCLYK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFL----IATVWTLGFAICSPlPVFHSLVELKETFGSALLSSKYLc 198
Cdd:cd15175  80 MSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFIskvsSLGVWVLAFILSIP-ELLYSGVNNNDGNGTCSIFTNNK- 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6981284  199 veswpsDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15175 158 ------QTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
53-238 8.72e-11

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 62.51  E-value: 8.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:cd15928  12 LVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFL-VLPLDLYRLWRYRpWRFGDLLCRLMYFFSETCTYASILH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  132 LISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLgfAICSPLPVFhSLVELKETFGSALL----------SSKYLCV 199
Cdd:cd15928  91 ITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAV--AIVSAGPAL-VLVGVEHIQGQQTPrgfectvvnvSSGLLSV 167
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  200 ESWPSDSYriaftislllvqYILPLVCLTVSHTSVCRSI 238
Cdd:cd15928 168 MLWVSTSF------------FFVPMVCLSLLYGLIGRAL 194
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
53-170 8.74e-11

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 62.12  E-value: 8.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15062  12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAI 170
Cdd:cd15062  92 CVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVI 131
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
51-177 1.15e-10

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 61.89  E-value: 1.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15334  10 LALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSIL 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  131 ILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15334  90 HLSAIALDRYRAITDAVeyARKRTPKHAGIMIAVVWIISIFISMP-PLF 137
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
47-174 1.33e-10

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 61.59  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15309   6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNL---TANHGYFLIATVWTLGFAICSPL 174
Cdd:cd15309  86 ASILNLCAISIDRYTAVAMPMLYNTrysSKRRVTVMISVVWVLSFAISCPL 136
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
50-238 1.37e-10

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 61.82  E-value: 1.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVL-LDQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15131   9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFL-CMPLDLYRLWqYRPWNFGDLLCKLFQFVSESCTYST 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  129 TLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFaiCSPLPVFhSLVELKETFGSALLSSKYLCVESWPSDS 206
Cdd:cd15131  88 ILNITALSVERYFAICFPLRAKVVVTKRRvkLVILVLWAVSF--LSAGPIF-VLVGVEHENGTNPIDTNECKATEYAVRS 164
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  207 YRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15131 165 GLLTIMVWVSSVFFFLPVFCLTVLYSLIGRKL 196
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
44-228 1.39e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 61.85  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15401   3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTAN--HGYFLIATVWTLgfAICSPLPVFHSlvelketfGSALLSSK-YLCVE 200
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNmkKTCCYVCLTWVL--TLAAIVPNFFV--------GSLQYDPRiYSCTF 152
                       170       180
                ....*....|....*....|....*...
gi 6981284  201 SWPSDSyriAFTISLLLVQYILPLVCLT 228
Cdd:cd15401 153 AQTVSS---SYTITVVVVHFIVPLSIVT 177
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
47-236 1.47e-10

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 61.81  E-value: 1.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15183   6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHslvelkeTFGSALLSSKYLCVESWPSDS 206
Cdd:cd15183  85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLY-------FFKSQWEFTHHTCSAHFPRKS 157
                       170       180       190
                ....*....|....*....|....*....|...
gi 6981284  207 ---YRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15183 158 lirWKRFQALKLNLLGLILPLLVMIICYTGIIN 190
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-268 1.70e-10

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 61.80  E-value: 1.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15357   6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNyPFLFGPVGCYFKTALFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSaLLSSKYLCVESWP 203
Cdd:cd15357  86 FASILSVTTVSVERYVAILHPFRAKLnsTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGT-LIPDSATCTVVKP 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  204 SDSYRIAFTISLLLVqYILPLVCLTVSHTSVcrsiscGLSHKENRLEENEMINLTLQ-PSKKSRNQ 268
Cdd:cd15357 165 LWIYNLIIQITSLLF-YVLPMGVISVLYYLM------GLKLRGDKSLEADEMNVNIQrPSRKSVTK 223
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
53-238 1.93e-10

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 61.34  E-value: 1.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd14975  12 AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLA-VLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLI 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHP-ISNNLTANHGYF-LIATVWTLGFAICSPLPVFHSLVELKEtfgsallssKYLCVESWPSDSYRIA 210
Cdd:cd14975  91 TLMSLERFLAVSRPfVSQGWRAKALAHkVLAIIWLLAVLLATPVIAFRHVEETVE---------NGMCKYRHYSDGQLVF 161
                       170       180
                ....*....|....*....|....*...
gi 6981284  211 FTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd14975 162 HLLLETVVGFAVPFTAVVLCYSCLLRRL 189
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-229 1.95e-10

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 61.30  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd14999   5 VLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALAD-LLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIA-TVWTLGFAICSPLPVFHSLVELKETFGsallSSKYLCVESWPSD 205
Cdd:cd14999  84 ASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAgVIWLLSLLLTLPMAIMIRLVTVEDKSG----GSKRICLPTWSEE 159
                       170       180
                ....*....|....*....|....
gi 6981284  206 SYRIAFTIsLLLVQYILPLVCLTV 229
Cdd:cd14999 160 SYKVYLTL-LFSTSIVIPGLVIGY 182
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
44-428 2.67e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 61.21  E-value: 2.67e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGlyTFVSLLGFM---GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL 120
Cdd:cd15065   1 LIG--IFLSLIIVLaifGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAIcSPLPVF---HSLVELKETFGSALLSSK 195
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLkyERWMTTRRALVVIASVWILSALI-SFLPIHlgwHRLSQDEIKGLNHASNPK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  196 YLCVESwpsdsyriaftislllvqyiLPLVClTVSHTSVCRSISCGLshkenrleeneMINLTLQpskksrnqaktpstq 275
Cdd:cd15065 158 PSCALD--------------------LNPTY-AVVSSLISFYIPCLV-----------MLLIYSR--------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  276 kwSYSFIRKHRRRYSKKTacvLPAPAGPSQgkhlAVPENPASVRSQLSPSSKVipgvpicfevkpeessdahemrvkrSI 355
Cdd:cd15065 191 --LYLYARKHVVNIKSQK---LPSESGSKF----QVPSLSSKHNNQGVSDHKA-------------------------AV 236
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  356 TrikkrsrsvfyrLTILILVFAVSWMPLHVFHVVTDFNDNLISnrhfKLVYCICHLLGMMSCCLNPILYGFLN 428
Cdd:cd15065 237 T------------LGIIMGVFLICWLPFFIINIIAAFCKTCIP----PKCFKILTWLGYFNSCLNPIIYSIFN 293
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
47-236 3.18e-10

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 60.54  E-value: 3.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15193   6 LYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIK--HPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsallssKYLCVESwPS 204
Cdd:cd15193  86 SSILFLTGMSVDRYLAVVklLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLIN------------ESVCVED-SS 152
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15193 153 SRFFQGISLATLFLTFVLPLIVILFCYCSILV 184
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
43-182 3.28e-10

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 60.58  E-value: 3.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFtLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15187   2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFV-FSLPF-QAYYLLDQWVFGNAMCKIVSGAYY 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVE 182
Cdd:cd15187  80 IGFYSSMFFITLMSIDRYLAIVHAVYalKVRTASHGTILSLALWLVAILASVPLLVFYQVAS 141
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
50-236 3.82e-10

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 60.79  E-value: 3.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLL---GFMGNLLILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGkAMCHIMPFLQCVSV 125
Cdd:cd15320   7 FLSVLilsTLLGNTLVCAAVIRFRHLRSKVtNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAIcSPLPVFHSLVELKET-FGSALLSSKYLCVESW 202
Cdd:cd15320  86 TASILNLCVISVDRYWAISSPFryERKMTPKVAFIMISVAWTLSVLI-SFIPVQLNWHKAKPTsFLDLNASLRDLTMDNC 164
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  203 PSDSYRIaFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15320 165 DSSLNRT-YAISSSLISFYIPVAIMIVTYTRIYR 197
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-143 5.15e-10

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 60.30  E-value: 5.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15977  12 LVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSL 91
                        90
                ....*....|.
gi 6981284  133 ISIAIVRYHMI 143
Cdd:cd15977  92 CALSIDRYRAV 102
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
44-232 5.34e-10

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 59.97  E-value: 5.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSlVELKETFGSAllsskyLCVES 201
Cdd:cd15091  82 NMFTSIFTLTMMSVDRYIAVCHPVKalDFRTPLKAKIINICIWLLSSSVGISAIVLGG-TKVREDVDST------ECSLQ 154
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  202 WPSDSYR---IAFTISLLLVQYILPLVCLTVSHT 232
Cdd:cd15091 155 FPDDDYSwwdTFMKICVFIFAFVIPVLIIIVCYT 188
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
47-177 5.37e-10

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 59.55  E-value: 5.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15335   6 TLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  127 VSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15335  86 CSILHLCVIALDRYWAITDAIeyARKRTAKRAGLMILTVWTISIFISIP-PLF 137
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
53-170 5.56e-10

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 59.91  E-value: 5.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6981284  133 ISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAI 170
Cdd:cd15326  92 CAISIDRYIGVRHSLQypTIVTRKRAILALLGVWVLSTVI 131
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
44-231 7.12e-10

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 59.58  E-value: 7.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15089   3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALAT-STLPFQSAKYLMETWPFGELLCKAVLSIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsallSSKYLCVES 201
Cdd:cd15089  82 NMFTSIFTLTMMSVDRYIAVCHPVKalDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPR--------DGAVVCMLQ 153
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  202 WPSDS--YRIAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15089 154 FPSPSwyWDTVTKICVFIFAFVVPILVITVCY 185
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
42-238 7.65e-10

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 59.40  E-value: 7.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlfCS-PFTLTSVLlDQWMFGKAMCHIMPFL 120
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFL--CTlPFWAYSAA-HEWIFGTVMCKITNGL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIkhpisnnLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKE-TFGSALLSSKYLCV 199
Cdd:cd15173  78 YTINLYSSMLILTCITVDRFIVI-------VQATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPQfIYSEVRNLSSKICS 150
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15173 151 MVYPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTL 189
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
40-177 7.79e-10

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 59.42  E-value: 7.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   40 LQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPF 119
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTlgFAICSPLPVF 177
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVeySKKRTPKRAAVMIALVWV--ISISISLPPF 140
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
40-424 7.79e-10

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 59.77  E-value: 7.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   40 LQYFLIGLYTFVSLLGfmgNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPF 119
Cdd:cd15058   2 GLLLLLALIILAIVVG---NLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGfAICSPLPVFHSLveLKETFGSALLSSKY- 196
Cdd:cd15058  79 VDVLCVTASIETLCVIAVDRYIAITRPLRYQvlLTKRRARVIVCVVWIVS-ALVSFVPIMNQW--WRANDPEANDCYQDp 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  197 LCVESWPSDSYRIAFTIslllVQYILPLVCLTVSHTSVCrsiscglshkenrLEENEMINLtlqpskksrnqaktpstqk 276
Cdd:cd15058 156 TCCDFRTNMAYAIASSV----VSFYIPLLIMIFVYARVF-------------LIATRQLQL------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  277 wsysfIRKHRRRYskKTACVLPAPAGPsqgkhlavpenPASVRSQLSPSSKVipgvpicfevkpeessdahemrvkrsit 356
Cdd:cd15058 200 -----IDKRRLRF--QSECPAPQTTSP-----------EGKRSSGRRPSRLT---------------------------- 233
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  357 rIKKRSRSVFyRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCichlLGMMSCCLNPILY 424
Cdd:cd15058 234 -VVKEHKALK-TLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLNW----LGYINSGLNPIIY 295
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
42-237 9.58e-10

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 59.25  E-value: 9.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLIL-MAVMKKRNQKTTVNFLIgNLAFSDILVvLFCSPFTLTSVLL-DQWMFGKAMCHIMPF 119
Cdd:cd15168   1 IFLPIVYGVVFLVGLLLNSVVLyRFIFHLKPWNSSAIYMF-NLAVSDLLY-LLSLPFLIYYYANgDHWIFGDFMCKLVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFhslvelketFGSALLSSKYL 197
Cdd:cd15168  79 LFYFNLYGSILFLTCISVHRYLGICHPLRslGKLKKRHAVAISVAVWILVLLQLLPILFF---------ATTGRKNNRTT 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  198 CVESWPSD------SYRIAFTISLLLVQYILPLVCLTVSHTSVCRS 237
Cdd:cd15168 150 CYDTTSPEelndyvIYSMVLTGLGFLLPLLIILACYGLIVRALIRK 195
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
45-189 1.09e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 59.19  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFgkAMCHIMPFLQCVS 124
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF--HGCLFMACLVLVL 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAIcSPLPVF--HSLVELKETFGS 189
Cdd:cd14968  82 TQSSIFSLLAIAIDRYLAIKIPLRYKslVTGRRAWGAIAVCWVLSFLV-GLTPMFgwNNGAPLESGCGE 149
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
47-178 1.29e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 58.99  E-value: 1.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15191   6 LYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVAD-LLFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTLNL 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6981284  126 LVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLgfAICSPLPVFH 178
Cdd:cd15191  85 FASIFFITCMSVDRYLAVVYPLrSQRRRSWQARLVCLLVWVL--ACLSSLPTFY 136
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
43-266 1.30e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 59.18  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYT-FVSLLGFMGNLLILMaVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ--WMFGKAM---CHI 116
Cdd:cd14978   1 VLYGYVLpVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYssSFLSYFYayfLPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  117 MPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVElKETFGSALLSS 194
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTwcTPRRARRVILIIIIFSLLLNLPRFFEYEVVE-CENCNNNSYYY 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  195 KYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIScgLSHKENRLEENEMINLTLQPSKKSR 266
Cdd:cd14978 159 VIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALR--KSKKRRRLLRRRRRLLSRSQRRERR 228
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
57-270 1.49e-09

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 58.68  E-value: 1.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   57 MGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:cd15385  16 IGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMMT 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  137 IVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallSSKYLC----VESWPSDSYRIAF 211
Cdd:cd15385  96 ADRYIAICHPLKTlQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENG------SGVYDCwanfIVPWGIKAYITWI 169
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  212 TISLllvqYILPLVCLTVSHTSVCRSISCGLSHK-ENRLEENEMINLTLQP---SKKSRNQAK 270
Cdd:cd15385 170 TISI----FVVPVIILLTCYGFICYNIWRNIKCKtRRGLSDNALKNILLAVcvsSVKTISRAK 228
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-185 1.64e-09

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 58.53  E-value: 1.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFtLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISD-LLFTFTLPF-WASYHSSGWIFGEILCKAVTSIFY 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIAT--VWTLGFAICSPLPVFHSLVELKE 185
Cdd:cd15182  80 IGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSvaVWVISILASLPELILSTVMKSDE 144
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
44-231 1.64e-09

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 58.47  E-value: 1.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15090   3 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGNILCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKylcves 201
Cdd:cd15090  82 NMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH------ 155
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  202 wPSDSYRIAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15090 156 -PSWYWENLLKICVFIFAFIMPVLIITVCY 184
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
43-248 1.67e-09

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 58.61  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVlLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15184   2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLL-FLLTLPFWAHYA-ANEWVFGNAMCKLLTGLYH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLP--VFHSLveLKEtfgsallSSKYLCVE 200
Cdd:cd15184  80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPgiIFTKS--QKE-------GSHYTCSP 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  201 SWPSDSYRI---AFTISLLLVQYILPLVCLTVSHTSVCRSI-SCGLSHKENR 248
Cdd:cd15184 151 HFPPSQYQFwknFQTLKMNILGLVLPLLVMIICYSGILKTLlRCRNEKKRHK 202
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
54-140 1.92e-09

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 58.33  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   54 LGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILI 133
Cdd:cd15127  13 IGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLC 92

                ....*..
gi 6981284  134 SIAIVRY 140
Cdd:cd15127  93 ALCIDRF 99
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
47-176 2.12e-09

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 58.37  E-value: 2.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15958   6 LMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGfAICSPLPV 176
Cdd:cd15958  86 ASIETLCVIAIDRYLAITSPFRYQslLTRARAKGIVCTVWAIS-ALVSFLPI 136
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
51-228 2.13e-09

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 58.24  E-value: 2.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPF-TLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15381  10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVC-CLPFwAINISNGFNWPFGEFLCKSVNAVIYMNLYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISNNLTANHGYFLIAT--VWTLGFAICSPLPVFHSLVELKETFGSAllsskylCVESWPSDSY 207
Cdd:cd15381  89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCliIWMFGLLMSTPMIVFRTVMYFPEYNITA-------CVLDYPSEGW 161
                       170       180
                ....*....|....*....|.
gi 6981284  208 RIAFTISLLLVQYILPLVCLT 228
Cdd:cd15381 162 HVALNILLNVVGFLIPLSIIT 182
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
47-174 2.25e-09

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 58.28  E-value: 2.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlfCS-PFTLTSVLLD-QWMFGKAMCHIMPFLQCVS 124
Cdd:cd15921   6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLV--CTlPLRLTYYVLNsHWPFGDIACRIILYVLYVN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNLTANH--GYFLIATVWTLGFAICSPL 174
Cdd:cd15921  84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHsvAGIICGLIWILMGLASSPL 135
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
47-231 2.27e-09

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 58.28  E-value: 2.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKK---RNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQC 122
Cdd:cd15338   6 VFGVICFLGIIGNSIVIYTIVKKskfRCQQTVPDIFIFNLSIVDLLFLL-GMPFLIHQLLGNGvWHFGETMCTLITALDT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKE-TFGSALLsskylcV 199
Cdd:cd15338  85 NSQITSTYILTVMTLDRYLATVHPIRSTKirTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDgSVGCALL------L 158
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  200 ESWPSDSYriAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15338 159 PNPETDTY--WFTLYQFFLAFALPLVVICVVY 188
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
47-173 2.59e-09

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 58.87  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    47 LYTFVSLLGFMGNLLILMAVMKKRnQKTTVNFLIGNLAFSD-ILVVLFcsPFTLTSVLlDQWMFGKAMCHIMPFLQCVSV 125
Cdd:PHA02638 104 FYIIIFILGLFGNAAIIMILFCKK-IKTITDIYIFNLAISDlIFVIDF--PFIIYNEF-DQWIFGDFMCKVISASYYIGF 179
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6981284   126 LVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:PHA02638 180 FSNMFLITLMSIDRYFAILYPISfqKYRTFNIGIILCIISWILSLIITSP 229
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
44-178 2.68e-09

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 57.90  E-value: 2.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVsLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQC 122
Cdd:cd15198   4 LIFLGVIL-VAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLgDRWMAGDVACRLLKLLQA 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTAnhgYFLIATVWTLGFAICSP-LPVFH 178
Cdd:cd15198  83 SARGASANLVVLLALDRHQAIRAPLGQPLRA---WKLAALGWLLALLLALPqAYVFR 136
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
47-231 2.78e-09

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 57.96  E-value: 2.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAV-MKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVS 124
Cdd:cd15925   6 AYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFAL-TLPFWAVESALDfHWPFGGAMCKMVLTATVLN 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYLCVESW 202
Cdd:cd15925  85 VYASVFLLTAMSVTRYWVVASAAgpGTHLSTFWAKIITLALWAAALLATVPTAIFATEGE---------VCGVELCLLKF 155
                       170       180
                ....*....|....*....|....*....
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15925 156 PSNYWLGAYHLQRVVVAFVVPLGVITTSY 184
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
43-245 3.01e-09

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493  Cd Length: 274  Bit Score: 57.50  E-value: 3.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLIL-MAVMKKRNQKTTVnfLIGNLAFSDILvvlFCS--PFTLTSVLL-DQWMFGKAMCHIMP 118
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNAIILwMLFFRLRSVCTAI--FYANLAISDLL---FCItlPFKIVYHLNgNNWVFGETMCRIIT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFAICSPLPVFHSLVELKETfgsALLSSKY 196
Cdd:cd15371  77 ITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYavLICALVWTIVFLYMLPFFILKQTYYLKEL---NITTCHD 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  197 LCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIScGLSHK 245
Cdd:cd15371 154 VLPECEQNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTLN-AYEHK 201
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
42-240 3.36e-09

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 57.65  E-value: 3.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKK-RNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLD-QWMFGKAMCHIMPF 119
Cdd:cd15170   1 WLVLAVYIITFLIGLPANLLAFYTFIRKvRRKPTPIDILLLNLTVSDLIFLLFL-PFKMAEAASGmIWPLPYFLCPLSSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATV--WTLGFAICSPLPVfhslVELKETFGSALLSSKYL 197
Cdd:cd15170  80 IFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVffWVLAFSHCSIVYI----VEYHIDSENTSVTNNSR 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6981284  198 CVESWPSDSYRI--AFTISLLLVQYILPLVCLTVSHTSVCRSISC 240
Cdd:cd15170 156 CYDNFTPEQLKIllPVRLELFLVLFCIPFLITCFCYINFIRILSS 200
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
38-234 3.38e-09

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 57.87  E-value: 3.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    38 DDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIgNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIM 117
Cdd:PHA03087  37 DTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLL-NLAVSDLLFVMTL-PFQIYYYILFQWSFGEFACKIV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   118 PFLQCVSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallssK 195
Cdd:PHA03087 115 SGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKinTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHET--------L 186
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 6981284   196 YLCVE-SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:PHA03087 187 ICCMFyNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKI 226
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-143 3.40e-09

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 57.56  E-value: 3.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15976   9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                        90
                ....*....|....
gi 6981284  130 LILISIAIVRYHMI 143
Cdd:cd15976  89 LSLCALSIDRYRAV 102
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
58-176 4.15e-09

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 57.57  E-value: 4.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAI 137
Cdd:cd15957  17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6981284  138 VRYHMIKHPISNN--LTANHGYFLIATVWTLGfAICSPLPV 176
Cdd:cd15957  97 DRYFAITSPFKYQslLTKNKARVIILMVWIVS-GLTSFLPI 136
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
51-179 4.97e-09

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 57.11  E-value: 4.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15056  10 VILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIM 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  131 ILISIAIVRYHMIKHPISnnltanHGYFLIATVWTLgFAICSPLPVFHS 179
Cdd:cd15056  90 HLCCIALDRYYAICCQPL------VYKMTPLRVAVM-LGGCWVIPTFIS 131
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
49-186 5.23e-09

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 56.94  E-value: 5.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15049   8 GSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNAS 87
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  129 TLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKET 186
Cdd:cd15049  88 VMNLLLISFDRYFSVTRPLTyrAKRTPKRAILMIALAWVISFVLWAPAILGWQYFVGERT 147
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
43-248 5.86e-09

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 56.70  E-value: 5.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLldQWMFGKAMCHIMPFLQC 122
Cdd:cd15179   2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAA--NWYFGNFLCKAVHVIYT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNN----LTANHgyFLIATVWTLGFAICSPLPVFHSLVElketfgsalLSSKYLC 198
Cdd:cd15179  80 VNLYSSVLILAFISLDRYLAIVHATNSQrprkLLAEK--VVYVGVWLPALLLTVPDLVFAKVSE---------LDDRYIC 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  199 VESWPSDS---YRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENR 248
Cdd:cd15179 149 DRIYPEDTfelWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRK 201
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
48-229 6.03e-09

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 57.09  E-value: 6.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15358   7 YLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNyPFLLGAGGCYFKTLLFETVCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLgfAICSPLP--VFHSLVELKeTFGSALLSSKYLCVESW 202
Cdd:cd15358  87 ASILNVTALSVERYIAVVHPLKAKyvVTRTHAKRVIGAVWVV--SILCSIPntSLHGIFQLT-VPCRGPVPDSATCMLVK 163
                       170       180
                ....*....|....*....|....*..
gi 6981284  203 PSDSYRIAFTISLLLVqYILPLVCLTV 229
Cdd:cd15358 164 PRWMYNLIIQITTLLF-FFLPMGTISV 189
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
49-236 6.24e-09

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 56.74  E-value: 6.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNLLILMAV---MKKRNQKTTVnFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15122   8 LLAALLGLPGNGFIIWSIlwkMKARGRSVTC-ILILNLAVAD-GAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHP-ISNNLTANH-GYFLIATVWTLGFAICSPLPVFHSLVElketfgsALLSSKYLCVESWP 203
Cdd:cd15122  86 YASIFIIGLMSLDRCLAVTRPyLAQSLRKKAlVRKILLAIWLLALLLALPAFVYRHVWK-------DEGMNDRICEPCHA 158
                       170       180       190
                ....*....|....*....|....*....|...
gi 6981284  204 SDSYRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15122 159 SRGHAIFHYTFETLVAFVLPFGVILFSYSVILV 191
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
44-166 6.66e-09

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 56.67  E-value: 6.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYT-FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQ 121
Cdd:cd15302   2 LLALITaILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNgDYWPLGWVLCDLWLSVD 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTL 166
Cdd:cd15302  82 YTVCLVSIYTVLLITIDRYCSVKIPAKyrNWRTPRKVLLIIAITWII 128
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
44-177 7.79e-09

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 56.13  E-value: 7.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYT-FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd17790   2 LIVITTgILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd17790  82 VASNASVMNLLIISFDRYFSITRPLTyrAKRTPRRAAIMIGLAWLISFVLWAPAILF 138
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
53-178 9.14e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 56.49  E-value: 9.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMK--KRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd14981  12 VFGVLGNLLALIVLARssKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFeWDGGQPLCDYFGFMMSFFGLSSL 91
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  130 LILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSpLPVFH 178
Cdd:cd14981  92 LIVCAMAVERFLAITHPFFYNshVKKRRARLMLGAVWAFALLIAS-LPLLG 141
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
51-178 9.67e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 56.05  E-value: 9.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCspFTLTSVLL----------DQWMfGKAMCHIMPFL 120
Cdd:cd15137  10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYL--LIIASVDLyyrgvyikhdEEWR-SSWLCTFAGFL 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAIcSPLPVFH 178
Cdd:cd15137  87 ATLSSEVSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLL-AVLPLLP 144
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-238 9.95e-09

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 56.39  E-value: 9.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKK---RNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL--DQWMFGKAMCHIMPFLQ 121
Cdd:cd15355   6 IYLALFVVGTVGNSITLYTLARKkslQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWvhHPWAFGDAACRGYYFLR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLpvfhsLVELKETFGSALLSSKYLCV 199
Cdd:cd15355  86 DACTYATALNVASLSVERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIPM-----LFTMGEQNRSGTHPGGLICT 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  200 ESWPSDSYRIAFTISLLLvQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15355 161 PIVDTSTLKVVIQVNAFL-SFLFPMLVISVLNTLIANQL 198
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
47-243 1.08e-08

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 55.96  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15366   6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPlPVFHslvelketfgSALLSSKY---LCVES 201
Cdd:cd15366  86 ISIAFLCCISVDRYLAVAHPLrfAKVRRVKTAVAVSAVVWAIEIGANSA-PLFH----------DELFRDRYnhtFCFEK 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLS 243
Cdd:cd15366 155 YPMEDWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNVS 196
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-239 1.35e-08

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 55.94  E-value: 1.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15189  10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISNNLTANHGYFLIATV--WTLGFAICSPLPVFHSLVELKETFGSAllsskylCVESWPSDSY 207
Cdd:cd15189  89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVliWVVGLLLSIPTFLLRKIKAIPDLNITA-------CVLLYPHEAW 161
                       170       180       190
                ....*....|....*....|....*....|..
gi 6981284  208 RIAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15189 162 HFAHIVLLNIVGFLLPLLVITFCNYNILQALR 193
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
43-173 1.40e-08

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 55.57  E-value: 1.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCH---IMPF 119
Cdd:cd15296   2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKlwlVVDY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  120 LQCVSVlVSTLILIS----IAIVRyhMIKHPISNNLTaNHGYFLIATVWTLGFAICSP 173
Cdd:cd15296  82 LLCTAS-VFNIVLISydrfLSVTR--AVSYRAQKGMT-RQAVLKMVLVWVLAFLLYGP 135
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
43-177 1.40e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 55.36  E-value: 1.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15297   2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFAICSPLPVF 177
Cdd:cd15297  82 VVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMagMMIAAAWVLSFILWAPAILF 138
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
43-146 1.46e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 55.64  E-value: 1.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDY 81
                        90       100
                ....*....|....*....|....
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHP 146
Cdd:cd15055  82 ILTSASIFNLVLIAIDRYVAVCDP 105
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
47-149 1.54e-08

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 55.52  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                        90       100
                ....*....|....*....|...
gi 6981284  127 VSTLILISIAIVRYHMIKHPISN 149
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPVQN 108
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
42-174 1.94e-08

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 55.30  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15377   1 YYLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISN--NLTANHGYFLIATVWTLGFAICSPL 174
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPLKSlgRLKKKNAICISVLVWLIVVVAISPI 135
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
47-236 1.96e-08

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 55.73  E-value: 1.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGkAMCHIMPFLQCVSV 125
Cdd:cd15319   6 LLSLLILWTLLGNILVCAAVVRFRHLRSKVtNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAIcSPLPV---FHSlvELKETFGSALLSSKYLCVE 200
Cdd:cd15319  85 TASILNLCVISVDRYWAISSPFryERKMTQRVALVMISVAWTLSVLI-SFIPVqlnWHK--DSGDDWVGLHNSSISRQVE 161
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  201 SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15319 162 ENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYR 197
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
42-238 1.97e-08

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 55.14  E-value: 1.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVlLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15174   1 YFLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLL-FLCTLPFWATAA-SSGWVFGTFLCKVVNSMY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPI----SNNLTANHGYFLIATVWTLGFAICSPLPVFHSlveLKETFGSALLSSKYl 197
Cdd:cd15174  79 KINFYSCMLLLTCISVDRYIAIVQATkahnSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQ---SKEEESVTTCTMVY- 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6981284  198 cvesWPSDSYRiaFTISLLLVQ----YILPLVCLTVSHTSVCRSI 238
Cdd:cd15174 155 ----PSNESNR--FKVAVLALKvtvgFFLPFVVMVICYTLIIHTL 193
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
46-177 2.19e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.99  E-value: 2.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   46 GLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDIL----VVLFCSPFTLTSVLLDQWMFgkamcHIMPFLQ 121
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagiaFVFTFLSVLLVSLTPSPATW-----LLRKGSL 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSpLPVF 177
Cdd:cd14972  78 VLSLLASAYSLLAIAVDRYISIVHGLTyvNNVTNKRVKVLIALVWVWSVLLAL-LPVL 134
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-145 2.21e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 55.17  E-value: 2.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMG 81
                        90       100
                ....*....|....*....|...
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKH 145
Cdd:cd15209  82 LSVIGSIFNITAIAINRYCYICH 104
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
50-178 2.23e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 54.74  E-value: 2.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15050   9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  130 LILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFH 178
Cdd:cd15050  89 FSLFILCIDRYRSVQQPLKylKYRTKTRASLMISGAWLLSFLWVIPILGWH 139
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-225 2.48e-08

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 54.84  E-value: 2.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15080   9 LLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIAL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETFGSALLSSKYLCVESWPSDSyr 208
Cdd:cd15080  89 WSLVVLAIERYVVVCKPMSNfRFGENHAIMGVAFTWVMALACAAP-PLVGWSRYIPEGMQCSCGIDYYTLKPEVNNES-- 165
                       170
                ....*....|....*..
gi 6981284  209 iaFTISLLLVQYILPLV 225
Cdd:cd15080 166 --FVIYMFVVHFTIPLI 180
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
41-186 2.58e-08

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 54.95  E-value: 2.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   41 QYFLIGLYT-FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPF 119
Cdd:cd15299   2 QVVLIAFLTgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKET 186
Cdd:cd15299  82 IDYVASNASVMNLLVISFDRYFSITRPLTyrAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRT 150
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
50-140 3.50e-08

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 54.36  E-value: 3.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFlqcVSVLVST 129
Cdd:cd15086   9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGF---ANSLFGI 85
                        90
                ....*....|.
gi 6981284  130 LILISIAIVRY 140
Cdd:cd15086  86 VSLISLAVLSY 96
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
48-259 3.84e-08

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 54.37  E-value: 3.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMK-KRNQKTTVNFLIgNLAFSDILvVLFCSPFTLTSVLLDqWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15181   7 YSLVFLLGVVGNGLVLTILLRrRRSRRTTENYLL-HLALADLL-LLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISN----NLTANHgyFLIATVWTLGFAICSPLPVFHSLvelkETFGSALLSSKYLCVESW 202
Cdd:cd15181  84 CSSLLLACISVDRYLAIVHAIHSyrhrRLRSVH--LTCGSIWLVCFLLSLPNLVFLEV----ETSTNANRTSCSFHQYGI 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIsCGLSHkenRLEENEMINLTL 259
Cdd:cd15181 158 HESNWWLTSRFLYHVVGFFLPLLIMGYCYATIVVTL-CQSSR---RLQKQKAIRVAI 210
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
44-176 4.13e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 54.26  E-value: 4.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15051   3 LGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVM 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAIcSPLPV 176
Cdd:cd15051  83 LCTASILNLFAISLDRYLAITAPLryPSRVTPRRVAIALAAIWVVSLAV-SFLPI 136
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
43-238 5.22e-08

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 54.09  E-value: 5.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15194   2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICspLPVFHSLvELKetfgsaLLSSKYLCVE 200
Cdd:cd15194  82 VNMYCSVFLLTCMSLDRYLAIVLPLVSRKfrTKHNAKVCCTCVWMLSCLLG--LPTLLSR-ELK------KYEEKEYCNE 152
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  201 SwPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15194 153 D-AGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKL 189
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
43-177 5.85e-08

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 53.68  E-value: 5.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFtLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15186   2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVA-TLPF-WTHYLINEWGLHNAMCKLTTAFFF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd15186  80 IGFFGGIFFITVISIDRYLAIVLAANsmNNRTVQHGVTISLGVWAAAILVAVPQFMF 136
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
45-183 8.04e-08

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 53.21  E-value: 8.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDILVVLFCsPFTLTSVLLD-QWMFGKAMCHIMPFLQC 122
Cdd:cd15119   4 IVIYIVAFVLGVPGNaIVIWVTGFKWKKTVNTLWFL--NLAIADFVFVLFL-PLHITYVALDfHWPFGVWLCKINSFVAV 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGFAICSPLPVFHSLVEL 183
Cdd:cd15119  81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKsaLILCGIVWLSAAAISGPALYFRDTMEL 143
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
49-173 8.23e-08

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 52.95  E-value: 8.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15324   8 VVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6981284  129 TLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSP 173
Cdd:cd15324  88 IVHLCAISLDRYWSVTKAVSYNLkrTPKRIKRMIAVVWVISAVISFP 134
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
40-228 9.69e-08

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 53.23  E-value: 9.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   40 LQYFLIGLYTFVslLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSvLLDQWMFGKAMCHIMPF 119
Cdd:cd15923   1 LLQYAIYIPTFV--LGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISL-PFKMHS-YRRESAGLQKLCNFVLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLI-ATVWTLGFAICSPLPVFHSLVElketfgsallssKYL 197
Cdd:cd15923  77 LYYINMYVSIFTITAISVDRYVAIRYPLrARELRSPRKAAVVcAVIWVLVVTISIPYFLLDSSNE------------KTM 144
                       170       180       190
                ....*....|....*....|....*....|.
gi 6981284  198 CVESwPSDSYRIAFTISLLLVQYILPLVCLT 228
Cdd:cd15923 145 CFQR-TKQTESLKVFLLLEIFGFLLPLIIMT 174
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
51-185 1.05e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 53.02  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFtltSVLLDQWMFgkAMCHIMPFLQC-VSVLVST 129
Cdd:cd15068  10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF---AITISTGFC--AACHGCLFIACfVLVLTQS 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981284  130 LI--LISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAI-CSPLPVFHSLVELKE 185
Cdd:cd15068  85 SIfsLLAIAIDRYIAIRIPLRYNglVTGTRAKGIIAICWVLSFAIgLTPMLGWNNCGQPKE 145
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
42-227 1.10e-07

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 53.18  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15378   1 YYLPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSD-LAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLvelketfGSALLSSKYLCVE- 200
Cdd:cd15378  80 HANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFI-------GPNLKDNVTKCKDy 152
                       170       180
                ....*....|....*....|....*...
gi 6981284  201 -SWPSDSYRIAFTISLLLVQYILPLVCL 227
Cdd:cd15378 153 aSSGDATNSLIYSLFLTVTGFLIPLCVM 180
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
44-176 1.24e-07

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 52.77  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPF-TLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15148   3 LAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIAD-LLLIICLPFrILYHVNNNQWTLGPLLCKVVGNLFY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPV 176
Cdd:cd15148  82 MNMYISIILLGFISLDRYLKINRSSRRQkfLTRKWSIVACGVLWAVALVGFVPMIV 137
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
42-146 1.51e-07

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 52.56  E-value: 1.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15126   1 YGILLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYME 80
                        90       100
                ....*....|....*....|....*
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHP 146
Cdd:cd15126  81 VTSLGVTTFSLCALGIDRFHAATSP 105
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
32-178 1.65e-07

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 52.60  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284    32 DYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQkTTVNFLIGNLAFSDILVVlFCSPFTLTSVlLDQWMFGK 111
Cdd:PHA02834  19 DFEMVNSDVNYFVIVFYILLFIFGLIGNVLVIAVLIVKRFM-FVVDVYLFNIAMSDLMLV-FSFPFIIHND-LNEWIFGE 95
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284   112 AMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPIS-NNLTANHGYFLIATVWTLGFAICSPLPVFH 178
Cdd:PHA02834  96 FMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKiKNKSISLSVLLSVAAWVCSVILSMPAMVLY 163
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
50-176 1.79e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 52.11  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  130 LILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGfAICSPLPV 176
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLrmTPPRALALILAAWTLA-ALASFLPI 136
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
40-177 1.95e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 52.64  E-value: 1.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   40 LQYFLIGLYTFVSLlgfMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-DQWMFGKAMCHIMP 118
Cdd:cd15217   2 VKLVLLGLIICVSL---AGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNgSAWTYSVLSCKIVA 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHP--ISNNLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15217  79 FMAVLFCFHAAFMLFCISVTRYMAIAHHrfYSKRMTFWTCIAVICMVWTLSVAMAFP-PVF 138
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
43-237 1.99e-07

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 52.09  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVlFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQ 121
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYA-LSLPLLIYNYAMrDRWLFGDFMCRLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCV 199
Cdd:cd15968  81 YFNLYGSILFLTCISVHRYLGICHPMRpwHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFP 160
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  200 ESWPsdsYRIAFTISLLLVQYILPLVCLTVSHTSVCRS 237
Cdd:cd15968 161 HYVP---YGMALTVSGFLLPFSIILWCYCLVVRTLCRT 195
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
44-231 1.99e-07

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 52.17  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKR---NQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ--WMFGKAMCHIMP 118
Cdd:cd15356   3 FTAVYALIWALGAAGNALTIHLVLKKRslrGLQGTVHYHLVSLALSDLLILLISVPIELYNFVWFHypWVFGDLVCRGYY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVW--TLGFAIcsPLPVFHSLVELKETFGSALLSS 194
Cdd:cd15356  83 FVRDICSYATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWasSLGFAL--PMAFIMGQKYELETADGEPEPS 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6981284  195 KYLCVESWPSDSYRIAFTISlLLVQYILPLV------CLTVSH 231
Cdd:cd15356 161 SRVCTVLVSRATLKVFIQVN-AFVSFVLPLAliaflnGVTVSH 202
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-143 2.04e-07

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 52.14  E-value: 2.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMF-----GKAMCHIMPFLQCVSV 125
Cdd:cd15128  10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKASV 89
                        90
                ....*....|....*...
gi 6981284  126 LVSTLILISIAIVRYHMI 143
Cdd:cd15128  90 GITVLNLCALSVDRYRAV 107
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
45-170 2.15e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 52.24  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFgkamcHIMPFLQC-V 123
Cdd:cd15069   4 VALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDF-----HSCLFLACfV 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  124 SVLVSTLI--LISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAI 170
Cdd:cd15069  79 LVLTQSSIfsLLAVAVDRYLAIKVPLRYKslVTGKRARGVIAVLWVLAFGI 129
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
56-178 2.26e-07

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 51.97  E-value: 2.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   56 FMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHimpFLQCVSVLVST---LIL 132
Cdd:cd15331  15 IIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCD---MWISMDVLCCTasiLHL 91
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  133 ISIAIVRYhmikHPISN-----NLTANHGYFLIATVWTLGFAICSPlPVFH 178
Cdd:cd15331  92 VAIALDRY----WAVTNidyirRRTAKRILIMIAVVWFVSLIISIA-PLFG 137
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-253 2.45e-07

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 52.07  E-value: 2.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15190  16 IYMLVFVLGLSGNGLVLWTVFRSKRKRRRSaDTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVFHSLVELkETFGSALLSSKYLCVESWP 203
Cdd:cd15190  96 YASVFCLTGLSFDRYLAIVRSLASAklRSRTSGIVALGVIWLLAALLALPALILRTTSDL-EGTNKVICDMDYSGVVSNE 174
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6981284  204 SDSYRIA-FTISLLLVQYILPLVCLTVSHTSVCRSIScglSHKENRLEENE 253
Cdd:cd15190 175 SEWAWIAgLGLSSTVLGFLLPFLIMLTCYFFIGRTVA---RHFSKLRRKED 222
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
50-173 2.57e-07

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 52.34  E-value: 2.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15218   9 FIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNgSTWTYGTLTCKVIAFLGVLSCFHT 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6981284  129 TLILISIAIVRYHMIKHP--ISNNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15218  89 AFMLFCISVTRYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
51-173 3.03e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 51.57  E-value: 3.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15300  10 VSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVM 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6981284  131 ILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15300  90 NLLVISFDRYFSITRPLTyrAKRTPKRAGIMIGLAWLISFILWAP 134
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
42-166 3.21e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 51.68  E-value: 3.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGfmgNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHI---MP 118
Cdd:cd15317   4 YIVLVLAMLITVSG---NLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFhtgLD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCvsvLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTL 166
Cdd:cd15317  81 LLLC---TTSIFHLCFIAIDRYYAVCDPLryPSKITVQVAWRFIAIGWLV 127
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-238 3.21e-07

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 51.72  E-value: 3.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:cd15132  12 VVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSD-LLILLCLPFDLYRLWKSRpWIFGEFLCRLYHYISEGCTYATILH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  132 LISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTlgFAICSPLPvFHSLVELKETFGSALLSSKYLCVES-WPSDSYR 208
Cdd:cd15132  91 ITALSIERYLAICFPLRAKVlvTRRRVKCVIAALWA--FALLSAGP-FLFLVGVEQDNNIHPDDFSRECKHTpYAVSSGL 167
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  209 IAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15132 168 LGIMIWVTTTYFFLPMLCLSFLYGFIGRKL 197
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
48-171 3.36e-07

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 51.73  E-value: 3.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGN---LLILMAVMKKRNQKTTVNFligNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15374   7 YGLVFVVGLPLNataLWLFIKRMRPWNPTTVYMF---HLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYAN 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWtLGFAIC 171
Cdd:cd15374  84 LYCSILFLTCISVHRYVGICHPIRalRWVKPRHAYLICASVW-LVVTVC 131
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
42-234 3.82e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 51.23  E-value: 3.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLL-ILMAVMKKRNQKTTVNFLIgNLAFSDILVVLfCSPFTLTS-VLLDQWMFGKAMCHIMPF 119
Cdd:cd15375   1 YYLPVMYSIIFIVGFPGNIIaIFVYLFKMRPWKSSTIIML-NLALTDLLYVT-SLPFLIYYyINGESWIFGEFMCKFIRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIA--TVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYL 197
Cdd:cd15375  79 IFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVAcaVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDN 158
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6981284  198 CVESWPsdsyriaFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:cd15375 159 LNTIWW-------YNWILTVLGFLLPLVIVTLCYTRI 188
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
42-167 3.98e-07

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 51.21  E-value: 3.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15072   1 FAVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISL-NALVAASSSLLRRWPYGSEGCQAHGFQG 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPisNNLTANHGYFLIATVWTLG 167
Cdd:cd15072  80 FFTALASICSSAAIAWDRYHHYCTR--SKLQWSTAISLVLFVWLFS 123
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
58-174 5.55e-07

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 50.60  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   58 GNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSP-FTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:cd15308  17 GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAIS 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6981284  137 IVRYHMIKHPISNNLT--ANHGYFLIATVWTLGFAICSPL 174
Cdd:cd15308  97 VDRFIAVSVPLNYNRRqgSVRQLLLISATWILSFAVASPV 136
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
50-238 7.22e-07

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 50.59  E-value: 7.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15076   9 FVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETFGSALLSSKYLCVESWPSDSYr 208
Cdd:cd15076  89 WSLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLP-PFFGWSRYIPEGLQCSCGPDWYTVGTKYRSEYY- 166
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  209 iafTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15076 167 ---TWFLFIFCFIVPLSIIIFSYSQLLGAL 193
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
49-146 7.23e-07

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 50.58  E-value: 7.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGNL--LILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15142   8 AVMFIFGVVGNLiaIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSL 87
                        90       100
                ....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHP 146
Cdd:cd15142  88 SGLSIICAMSIERYLAINHA 107
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
44-237 8.13e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 50.12  E-value: 8.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFAICSPLPVFHSLVElketfgsallsskylcVES 201
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKtrVIILGCWGVSLLLSIPPLVGKGAIP----------------RYN 144
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRS 237
Cdd:cd14964 145 TLTGSCYLICTTIYLTWGFLLVSFLLPLVAFLVIFS 180
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
47-231 8.46e-07

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 50.19  E-value: 8.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15972   6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGL-PFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallsskylCVESW-- 202
Cdd:cd15972  85 TSIFCLTVMSVDRYLAVVHPIrsSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGT-----------CHIAWpe 153
                       170       180
                ....*....|....*....|....*....
gi 6981284  203 PSDSYRIAFTISLLLVQYILPLVCLTVSH 231
Cdd:cd15972 154 PAQVWRAGFIIYTATLGFFCPLLVICLCY 182
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
57-239 9.95e-07

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135  Cd Length: 289  Bit Score: 50.26  E-value: 9.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   57 MGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTL---TSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILI 133
Cdd:cd15006  15 LGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIvlsASPHCCWWIYTLLFCKVIKFLHKVFCSVTVLSFA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  134 SIAIVRYHMIKHPISNNLTANHGYFLIATVWTlgFAICSPLPVFhSLVELKETFGSAllsskyLCVESWPSDSYRIAFTI 213
Cdd:cd15006  95 AIALDRYYSVLYPLERKISDAKSRDLVIYIWA--HAVVASVPVF-AVTNVTDIYAMS------TCTESWGYSLGHLVYVI 165
                       170       180
                ....*....|....*....|....*.
gi 6981284  214 SLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15006 166 IYNITTVILPVAVVFLFMILIRRALS 191
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
44-177 1.10e-06

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 49.78  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLL-GFMGNLLIL-MAVMKKRNQKTTVNFL---IGNLAFSDILvvlfcsPFTLTSVLLD-QWMFGKAMCHIM 117
Cdd:cd15120   2 LIAVALFVTFLvGLVVNGLYLwVLGFKMRRTVNTLWFLhliLSNLIFTLIL------PFMAVHVLMDnHWAFGTVLCKVL 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  118 PFLQCVSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd15120  76 NSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQhrTNRWASAIVLGVWISAILLSIPYLAF 137
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
47-176 1.12e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 49.91  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15959   6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAIcSPLPV 176
Cdd:cd15959  86 ASIETLCAIAVDRYLAITNPLRYEalVTKRRARTAVCLVWAISAAI-SFLPI 136
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
47-257 1.13e-06

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 49.85  E-value: 1.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGN---LLILMAVMKKRNQKTTvnFLIgNLAFSDILVVlFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15156   6 VFSMVFVLGLIANcvaIYIFMCTLKVRNETTT--YMI-NLAISDLLFV-FTLPFRIFYFVQRNWPFGDLLCKISVTLFYT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSAllsskylCVES 201
Cdd:cd15156  82 NMYGSILFLTCISVDRFLAIVYPFRSKTlrTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSET-------CFEN 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6981284  202 WPSDSYRIAFT---ISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINL 257
Cdd:cd15156 155 FSSKTWKTYLSkivIFIEIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKLNKKKVLKM 213
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
43-177 1.16e-06

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 49.78  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKK-RNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVlLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15188   2 FLPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLV-TLPFWAMYV-AWHWVFGSFLCKFVSTLY 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIAT-VWTLGFAICSPLPVF 177
Cdd:cd15188  80 TINFYSGIFFVSCMSLDKYLEIVHAQSPhRLRTRRKSLLVLVaVWVLSIALSVPDMVF 137
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
47-234 1.62e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 49.48  E-value: 1.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15084  16 LMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPlPVFHSLVELKETFGSAllsskylCVESW-PS 204
Cdd:cd15084  96 VGLWSLAILAFERYLVICKPMGDfRFQQRHAVSGCAFTWGWSLLWTSP-PLFGWSSYVPEGLRTS-------CGPNWyTG 167
                       170       180       190
                ....*....|....*....|....*....|
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:cd15084 168 GTNNNSYILALFVTCFALPLSTIIFSYSNL 197
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
43-145 1.76e-06

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 49.44  E-value: 1.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15078   2 LLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNS 81
                        90       100
                ....*....|....*....|...
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKH 145
Cdd:cd15078  82 LFGIVSIMTLTVLAYERYIRVVH 104
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
53-147 1.83e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 49.09  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91
                        90
                ....*....|....*
gi 6981284  133 ISIAIVRYHMIKHPI 147
Cdd:cd15318  92 CFISIDRHCAICDPL 106
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
43-238 1.90e-06

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 49.05  E-value: 1.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGfmgNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCH---IMPF 119
Cdd:cd15295   5 FLMSLLALVIVLG---NALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVfwlVIDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  120 LQCvSVLVSTLILISIAivRYHMIKHPIS----NNLTANHGYFLIAtVWTLGFAICSPLPVFHSLVELKETfgsallssk 195
Cdd:cd15295  82 LLC-TASVYNIVLISYD--RYQSVSNAVSyrnqQTATLRIVTQMVA-VWVLAFLVHGPAILVSDSWKTEDG--------- 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6981284  196 yLCVESWPSDSYRIAfTISLLlvQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15295 149 -ECEPEFFSNWYILA-ITSVL--EFLVPVILVAYFNTQIYWSL 187
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
51-238 3.39e-06

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 48.64  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15380  10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFWAENIRNQfNWPFGNFLCRVISGVIKANLFISI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  130 LILISIAIVRYHMIKHPISN--NLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSAllsskylCVESWPSDSY 207
Cdd:cd15380  89 FLVVAISQDRYRTLVHTMTSrrQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISA-------CILLFPHEAW 161
                       170       180       190
                ....*....|....*....|....*....|.
gi 6981284  208 RIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15380 162 HFARRVELNIVGFLLPLAAIVFFNFHIIASL 192
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
47-238 3.44e-06

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 48.21  E-value: 3.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIgNLAFSDILVVLFCsPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSV 125
Cdd:cd15372   6 LYTLVFLVGLPANGLALWVLATQVKRLPSTIFLI-NLAVADLLLILVL-PFKISYHFLGNnWPFGEGLCRVVTAFFYGNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCVESWP 203
Cdd:cd15372  84 YCSVLLLMCISLDRYLAVVHPFFARTlrSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLER-------LNITLCHDVLP 156
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  204 SD---SYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15372 157 LDeqdTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTL 194
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
53-182 3.92e-06

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 48.19  E-value: 3.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDILVVLFCsPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVLVSTL 130
Cdd:cd15117  12 VLGTLGNgLVIWVTGFRMTRTVTTVCFL--NLAVADFAFCLFL-PFSVVYTALGfHWPFGWFLCKLYSTLVVFNLFASVF 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6981284  131 ILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVE 182
Cdd:cd15117  89 LLTLISLDRCVSVLWPVwaRNHRTPARAALVAVGAWLLALALSGPHLVFRDTRK 142
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
43-241 4.99e-06

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 47.76  E-value: 4.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVllDQWMFGKAMCHIMPFLQC 122
Cdd:cd15180   2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV--HGWIFGTGLCKLAGAVFK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPIS----NNLTANHGYFLIatVWTLGFAICSPLPVFhslveLKETFGSALlsSKYLC 198
Cdd:cd15180  80 INFYCGIFLLACISFDRYLSIVHAVQmysrKKPMLVHLSCLI--VWLFCLLLSIPDFIF-----LEATKDPRQ--NKTEC 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 6981284  199 VESWPSDS--YRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCG 241
Cdd:cd15180 151 VHNFPQSDtyWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRS 195
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
43-174 4.99e-06

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 47.64  E-value: 4.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQ 121
Cdd:cd15328   2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANH--GYFLIATVWTLGFAIC-SPL 174
Cdd:cd15328  82 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRriSNVMIALTWALSAVISlAPL 137
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
42-224 5.17e-06

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 47.81  E-value: 5.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVN-FLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFL 120
Cdd:cd14983   1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSL-PIKIVEALSSAWTLPAVLCPLYNLA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPISNNLT--ANHGYFLIATVWTLGFAICsplpvfhSLVELKETFGSALLSS---- 194
Cdd:cd14983  80 HFSTLYASTCFLTAISAGRYLGVAFPIKYQLYkkPLYSCLVCVAIWALVIFHV-------TLVFILETSGGTLDINtpvg 152
                       170       180       190
                ....*....|....*....|....*....|....*
gi 6981284  195 -KYLCVESWPSDSYRIA----FTISLLLvqYILPL 224
Cdd:cd14983 153 nSSTCYENFTPEQLALLapvrLELSLVL--FFLPL 185
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-176 6.47e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 47.63  E-value: 6.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRN---QKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQ--WMFGKAMCHIMPFLQ 121
Cdd:cd15130   6 IYLALFVVGTVGNSVTLFTLARKKSlqsLQSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHhpWAFGDAGCRGYYFLR 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPV 176
Cdd:cd15130  86 DACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPMLF 142
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
43-248 7.36e-06

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 47.44  E-value: 7.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQ 121
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVI-WLPFKIAYHIHGNnWIFGEALCRLVTVAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIAT--VWTLGFAICSPLPVFHSLVELKEtfgsallSSKYLCV 199
Cdd:cd15162  81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTClaIWLLALLVTLPLYLVKQTIFLPA-------LDITTCH 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  200 ESWPSD---SYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENR 248
Cdd:cd15162 154 DVLPEQllvGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEK 205
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-172 7.86e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 47.52  E-value: 7.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15133   7 YLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNyPFLLGSGGCYFKTFLFETVCL 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFaICS 172
Cdd:cd15133  87 ASILNVTALSVERYIAVVHPLAARTcsTRPRVTRVLGCVWGVSM-LCA 133
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
43-238 8.54e-06

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 47.06  E-value: 8.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILM--AVMKKRNQKTTVNFLigNLAFSDILVVLfCSPFTLTSvLLDQWMFGKAMCHIMPFL 120
Cdd:cd15172   2 FVPVIYSLICVVGLIGNSLVVItyAFYKRTKSMTDVYLL--NMAIADILFVL-TLPFWAVY-EAHQWIFGNFSCKLLRGI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPI-SNNL---TANHGYFLIATVWTLGFAICSPLPVFHSLVELKetfgsalLSSKY 196
Cdd:cd15172  78 YAINFYSGMLLLACISVDRYIAIVQATkSFRLrsrTLAYSKLICAAVWLLAILISLPTFIFSEVYDFG-------LEEQY 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  197 LCVESWPSDSYRIAFTISLLLVQ----YILPLVCLTVSHTSVCRSI 238
Cdd:cd15172 151 VCEPKYPKNSTAIMWKLLVLSLQvslgFFIPLLVMIFCYSFIIKTL 196
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
44-234 1.17e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 46.68  E-value: 1.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKT-TVNFLIgNLAFSDiLVVLFCSPFTLT-SVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15368   3 LPVVYSLVALISIPGNLFSLWLLCFHTKPKTpSIIFMI-NLSLTD-LMLACFLPFQIVyHIQRNHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATV--WTLGFAICSPL---PVFHSLVELKETFGSALLSSKY 196
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIgmWLLVLTALSPLertDLTYYVKELNITTCFDVLKWTM 160
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6981284  197 LcveswPSDSYRIAFTISLLLVQYILPLVCLTVSHTSV 234
Cdd:cd15368 161 L-----PNIAAWAAFLFTLFILLFLIPFIITVYCYVLI 193
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
44-147 1.36e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 46.78  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15316   3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82
                        90       100
                ....*....|....*....|....
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPI 147
Cdd:cd15316  83 FCYASLFHLCFISVDRYIAVTDPL 106
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
50-177 1.41e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 46.36  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15077   9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSL 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  130 LILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15077  89 WSLAVVAFERFLVICKPLGNfTFRGTHAIIGCIATWVFGLAASLP-PLF 136
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
48-174 1.52e-05

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 46.58  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15159   7 YSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTL-ALPGRIAYYALGfDWPFGDWLCRLTALLFYINTY 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPL 174
Cdd:cd15159  86 AGVNFMTCLSVDRYIAVVHPLrrHRLRKVKVVRYICVFVWVLVFLQTLPL 135
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
43-239 1.64e-05

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 46.30  E-value: 1.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLL-DQWMFGKAMCHIMPFLQ 121
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLL-PFKIAYHFSgNDWLFGEAMCRVVTAAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKE---TFGSALLSSKY 196
Cdd:cd15369  81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSwrTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDlgiTTCHDVLNEQL 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6981284  197 LcveswpsDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15369 161 L-------MGYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLS 196
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
53-224 1.64e-05

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 46.29  E-value: 1.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:cd14991  12 VLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL-LICLPFRIDYYLRGEhWIFGEAWCRVNLFMLSVNRSASIAF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  132 LISIAIVRYHMIKHP--ISNNLTANHGYFLIATVWTLGFAICSPLpvfhSLVELKETFGSALLSSKYLcveSWPSDSYRI 209
Cdd:cd14991  91 LTAVALDRYFKVVHPhhRVNRMSVKAAAGVAGLLWALVLLLTLPL----LLSTLLTVNSNKSSCHSFS---SYTKPSLSI 163
                       170
                ....*....|....*
gi 6981284  210 AFTISLLLVQYILPL 224
Cdd:cd14991 164 RWHNALFLLEFFLPL 178
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
43-246 2.01e-05

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 45.93  E-value: 2.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQ 121
Cdd:cd15364   2 FLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCE-LLYLGTLPLWTIYVSNNhKWPWGSLACKITGYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATvwtlgFAICSPLPVFHSLVELKEtfgSALLSSKYLCVES 201
Cdd:cd15364  81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFIS-----FLIFIVVGLVHSPVFIMR---EGQTEGSHTCFET 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6981284  202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI--SCGLSHKE 246
Cdd:cd15364 153 LQMDTQVAGFYYARFCIGFAIPLAILIFTNYRIFRSIqtSTSLTPHQ 199
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
51-247 2.11e-05

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 46.01  E-value: 2.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMF-----GKAMCHIMPFLQCVSV 125
Cdd:cd15975  10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKhpiSNNLTANHGYFLIA-----TVWTLGFAICSPLPVFHSLVELK---ETFGSALL--SSK 195
Cdd:cd15975  90 GITVLNLCALSVDRYRAVA---SWSRVQGIGIPLITaieifSIWVLSFILAIPEAIGFVMVPFEyngEQYRTCMLnaTTK 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  196 YLCVESWPSDSYRIAFtislllvQYILPLVCLTVSHTsvcrSISCGLSHKEN 247
Cdd:cd15975 167 FMNFYVDAKDWWLFGF-------YFCVPLACTAIFYT----LMTCEMLNRRK 207
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
47-166 2.29e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.93  E-value: 2.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD------QWMFGKAMCHIMPFL 120
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADmgylnrRGPFETKLDDIMDSL 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTL 166
Cdd:cd15350  86 FCLSLLGSIFSILAIAADRYITIFHALRyhNIMTMRRTLVILAIIWTF 133
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
43-180 2.41e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 45.84  E-value: 2.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLI--LMAVMKKRNQKTTVNFLIgNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFL 120
Cdd:cd15376   2 FLWPILGVEFLVAVLGNGLAlwLFVTRERRPWHTGVVFSF-NLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  121 QCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSL 180
Cdd:cd15376  81 FTCNLYGSIFFITCISLNRYLGIVHPFftRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHL 142
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
47-435 2.57e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 45.86  E-value: 2.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGN-LLILMAVMKKRNQKTTVNFLigNLAFSDILVVLfCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVS 124
Cdd:cd15114   6 LYAVVFLVGVPGNaLVAWVTGFEAKRSVNAVWFL--NLAVADLLCCL-SLPILAVPIAQDgHWPFGAAACKLLPSLILLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVElkETFgsallSSKYLCVESW 202
Cdd:cd15114  83 MYASVLLLTAISADRCLLVLRPVwcQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQ--EHF-----PEKTVCVVDY 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  203 PSD-SYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIScglshkenrleeneminltlqpskksrnqaktpstqkwsysf 281
Cdd:cd15114 156 GGStGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTW------------------------------------------ 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  282 irkhRRRYSKKTacvlpapagpsqgKHLAVpenpasvrsqlspsskvipgvpicfevkpeessdahemrvkrsitrikkr 361
Cdd:cd15114 194 ----SRRRQKSR-------------RTLKV-------------------------------------------------- 206
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  362 srsvfyrLTILILVFAVSWMPLHVFHV---VTDFNDNLISNrhFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd15114 207 -------VTAVVVGFFLCWTPYHVVGLiiaASAPNSRLLAN--ALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
48-179 2.63e-05

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 45.55  E-value: 2.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd15153   7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVL-SLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYA 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  128 STLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPLPVFHS 179
Cdd:cd15153  86 SICFLTCISIQRCFFLLHPFkARDWKRRYDVGISAAVWIVVGLACLPFPLLRS 138
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
47-146 2.89e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 45.58  E-value: 2.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRnQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSV 125
Cdd:cd15339   6 FIGILCSTGLVGNILVLFTIIRSR-KKTVPDIYVCNLAVAD-LVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQ 83
                        90       100
                ....*....|....*....|.
gi 6981284  126 LVSTLILISIAIVRYHMIKHP 146
Cdd:cd15339  84 FACSAIMTAMSLDRYIALVHP 104
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
47-239 3.10e-05

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 45.64  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15379   6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTNLH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPIS---NNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWP 203
Cdd:cd15379  86 GSILFLTCISVQRYLGICHPLAswhKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARSTAYFP 165
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6981284  204 sdsYRIAFTISLLLVQYILPLVCLTVSHTSVCRSIS 239
Cdd:cd15379 166 ---YGITLTRTGFLLPFAARLACYCSMATILCRVVI 198
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
48-143 3.20e-05

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 45.54  E-value: 3.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILvVLFCSPFTLTSVLLDqWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd15177   7 YLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLL-LLLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFYS 84
                        90
                ....*....|....*.
gi 6981284  128 STLILISIAIVRYHMI 143
Cdd:cd15177  85 GFLFLTCISVDRYVVI 100
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
47-169 3.27e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 45.42  E-value: 3.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVS---LLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15312   3 MYLFMAgaiLLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMM 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFA 169
Cdd:cd15312  83 LSTTSIFHLCFIAVDRYYAVCDPLhyRTKITTPVIKVFLVISWSVPCL 130
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
58-170 3.56e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 45.44  E-value: 3.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   58 GNLLILMAVMK-KRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIA 136
Cdd:cd15104  16 GNLLVIVALLKlIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAAIA 95
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6981284  137 IVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAI 170
Cdd:cd15104  96 FDRYLALKQPLryKQIMTGKSAGALIAGLWLYSGLI 131
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
47-145 4.91e-05

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 45.18  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvlfCS--PFTLTSVLLDQ-WMFGKAMCHIMPFLQC- 122
Cdd:cd14996   6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLV---CSamPFQAAYFLKGFyWKYQSTQCRIANFFGTl 82
                        90       100
                ....*....|....*....|....*..
gi 6981284  123 ---VSVLVSTLILISIAIVRYH-MIKH 145
Cdd:cd14996  83 vihVSMCVSILILSWIAISRYAtLMKH 109
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
48-259 5.52e-05

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 44.70  E-value: 5.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLD-QWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15161   7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLIL-PMRLVYHLSGnHWPFGEVPCRLAGFLFYLNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPI-SNNL-TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLsskYLCVESwps 204
Cdd:cd15161  86 ASLYFLACISVDRFLAIVHPVkSMKIrKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQL---YREKAS--- 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981284  205 dsyriAFTISLLLVQYILPLVCLTVSHTSVCRSISCGlSHKENRLEEN--EMINLTL 259
Cdd:cd15161 160 -----RGALVSLAVAFTIPFVTTVTCYLLIIRSLRTG-KREEKPLKDKaiKMIILVL 210
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
54-237 7.88e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 44.06  E-value: 7.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   54 LGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILI 133
Cdd:cd15215  12 ASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  134 SIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTlgFAICSPLPVFHSlvelketFGSALLSSKY-LCVESWPSdSYriA 210
Cdd:cd15215  92 VVSVDRYLAIIHPLSypTKMTPRRGYLLIYGTWI--VSVLQSTPPLYG-------WGQAAFDERNaLCSVIWGS-SY--S 159
                       170       180
                ....*....|....*....|....*..
gi 6981284  211 FTISLLLVQYILPLVCLTVSHTSVCRS 237
Cdd:cd15215 160 YTILSVVSSFVLPVIIMLACYSMVFRA 186
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
43-248 8.16e-05

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 43.99  E-value: 8.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDiLVVLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQ 121
Cdd:cd14988   2 VLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIAD-LGVVLTLPVWMLEVMLDYtWLWGSFLCKFTHYFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGFAICSPLPVFHSLVELKETFGsallsskYLCV 199
Cdd:cd14988  81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRirRALCAGIWVLSAIIPLPEVVHMQLLDGVEPMC-------LFLA 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  200 ESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCgLSHKENR 248
Cdd:cd14988 154 PFETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRT-AGRPESR 201
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
44-236 9.26e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.99  E-value: 9.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15219   2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVpGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLET 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVW--TLGFAICSplpVFHSLVELKETFGSALLSSKYlc 198
Cdd:cd15219  82 FLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDaaLMVGYSWlhSLTFSLVA---LFLSWLGYSSLYASCTLHLPR-- 156
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6981284  199 veswPSDSYRIA-FTISLLLVQYILPLVCLTVSHTSVCR 236
Cdd:cd15219 157 ----EEERRRFAvFTAFFHAFTFLLSLLVLCVTYLKVLK 191
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
43-250 1.05e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 44.02  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15082  15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFaICSPLPVFHSLVELKETFGSAllsskylCVES 201
Cdd:cd15082  95 FFGIVALWSLAVLAFERFFVICRPLGNiRLQGKHAALGLLFVWTFSF-IWTIPPVLGWSSYTVSKIGTT-------CEPN 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYR-IAFTISLLLVQYILPLVCLTVSHTSVCRSIScGLSHKENRLE 250
Cdd:cd15082 167 WYSGNMHdHTYIITFFTTCFILPLGVIFVSYGKLLQKLR-KVSNTQGRLG 215
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
53-146 1.11e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 43.89  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   53 LLGFMGNLLIL-MAVMKKRNQKTTVNFLIgNLAFSDILVvLFCSPFTlTSVLL--DQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15201  12 VLGLLGNGLALwIFCFHLKSWKSSTVYLF-NLAVADFLL-IICLPFR-TDYYLrgKHWKFGDIPCRIVLFMLAMNRAGSI 88
                        90
                ....*....|....*..
gi 6981284  130 LILISIAIVRYHMIKHP 146
Cdd:cd15201  89 FFLTAVAVDRYFRVVHP 105
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
52-248 1.30e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 43.69  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   52 SLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:cd15085  11 ATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  132 LISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLG-FAICSPLPVFHSlvelketFGSALLSSKylCVESWPSDSYR- 208
Cdd:cd15085  91 LTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFClFWAVAPLFGWSS-------YGPEGVQTS--CSIGWEERSWSn 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6981284  209 IAFTISLLLVQYILPLVCLTVSHTSVCRSIscglsHKENR 248
Cdd:cd15085 162 YSYLILYFLMCFVIPVAIIGFSYGNVLRSL-----HKLNK 196
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
47-257 1.33e-04

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 43.57  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15192   6 VYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELKETfgsallsSKYLCVESWPS 204
Cdd:cd15192  86 ASVFLLTCLSIDRYLAIVHPMKSRLrrTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENT-------NITVCAFHYPS 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  205 DSYRIAFTISLL--LVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINL 257
Cdd:cd15192 159 QNSTLLVGLGLMknLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNDEIFKM 213
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
47-165 1.36e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 43.36  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL-----DQWMFGKAMCHIMPFLQ 121
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLngndtDAQSFTVNIDNVIDSVI 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWT 165
Cdd:cd15353  86 CSSLLASICSLLSIAVDRYFTIFYALQyhNIMTVRRAGVIITCIWT 131
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
42-180 1.37e-04

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 43.45  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMC----HIM 117
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCisqlHFF 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  118 PFLQCVSVlvstLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFaicsplpvFHSL 180
Cdd:cd15915  81 HFLGSSEA----MLLAVMAYDRYVAICNPLRYTVIMNPQVclLLAVACWVTGF--------FHAL 133
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
47-193 1.54e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 43.19  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15087   6 IYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVL-PINIAEHLLQQWPFGELLCKLILSIDHYNIF 84
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIAT----VWTLGFAICSPLPVFHSLVELKETFGSALLS 193
Cdd:cd15087  85 SSIYFLTVMSVDRYLVVLATVRSRRMPYRTYRAAKIvslcVWLLVTIIVLPFTVFAGVYSNELGRKSCVLS 155
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
48-150 1.61e-04

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 43.17  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLL---ILMAVMKKrnQKTTVNFLIgNLAFSDILVVLfCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15152   7 YTVILIPGLIGNVLalwVFYAYVKE--TKRAVIFMI-NLAIADLLQVL-SLPLRIFYYLNKSWPFGKFLCMFCFYLKYVN 82
                        90       100
                ....*....|....*....|....*.
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNN 150
Cdd:cd15152  83 MYASIYFLVCISVRRCLYLIYPFRYN 108
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
45-238 1.73e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 43.22  E-value: 1.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   45 IGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15388   4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPIsnnLTANHGYFL----IATVWTLGFAICSPLPVFHSLVELKetfgsallSSKYLC-- 198
Cdd:cd15388  84 MFASSYMIVAMTFDRHQAICRPM---VTFQKGRARwngpVCVAWAISLILSLPQVFIFSKVEVA--------PGVYECwa 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6981284  199 --VESWPsdsyRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15388 153 cfIEPWG----LKAYVTWITLVVFVLPTLIITVCQVLIFKEI 190
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
52-170 1.77e-04

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 42.97  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284     52 SLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLtsVLLDQWMFGKAMCHIMPFLQCVSVLVSTLI 131
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVV--LLFTGTQLTRNECFWMISFYIFGQTAQGPL 78
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 6981284    132 LISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAI 170
Cdd:pfam10320  79 MLMIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSS 117
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-165 1.88e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 42.86  E-value: 1.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   46 GLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL------DQWMFGKAMCHIMPF 119
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLnngylvPRDSFEQHIDNVIDS 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWT 165
Cdd:cd15103  85 MICSSLLASICSLLAIAVDRYITIFYALRyhSIMTVRRAGVIITAIWV 132
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
47-179 2.29e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 42.89  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCsPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15166   6 FYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSL-PFRMVYYAKDEWPFGDYFCRILGALTVFYPS 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  127 VSTLILISIAIVRYHMIKHPISNNLTANHGYFLIAT--VWTLGFAICSPLPVFHS 179
Cdd:cd15166  85 IALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACvgVWIMTLASTFPLLFLYE 139
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
48-238 3.55e-04

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 42.06  E-value: 3.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvLFCSPFTLTSVLL-DQWMFGKAMCHIMPFLQCVSVL 126
Cdd:cd15367   7 YILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLY-IFSLPFWLQYVLQhDNWTYSELLCKICGILLYENIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  127 VSTLILISIAIVRYHMIKHPIS-NNLTANHGYFLIATV-WTLGFAICSplpVFHSLVELKETfgsalLSSKYLCVESWPS 204
Cdd:cd15367  86 ISIGFLCCISVDRYLAVVHPFRfHAFRTMKAATLVSTViWLKELMTCV---FFFLHGEISKD-----KENHSVCFEHYPI 157
                       170       180       190
                ....*....|....*....|....*....|....
gi 6981284  205 DSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15367 158 KAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAV 191
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
47-238 4.93e-04

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 41.83  E-value: 4.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   47 LYTFVSLLGFMGN---LLILMAVMKKRNQKTtvnFLIGNLAFSDILVVlFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15155   6 VYSVVFILGLITNcasLFVFCFRMKMRNETA---IFMTNLAVSDLLFV-FTLPFKIFYNFNRHWPFGDSLCKISGTAFLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSlvelketfgSALLSSKYLCVES 201
Cdd:cd15155  82 NIYGSMLFLTCISVDRFLAIVYPFRSRTirTRRNSAIVCAGVWILVLSGGISASLFST---------TNVSNTSTTCFEG 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYRI---AFTISLLLVQYILPLVCLTVSHTSVCRSI 238
Cdd:cd15155 153 FSKSIWKTylsKITIFIEVVGFIIPLLLNLTCSSLVLRTL 192
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
49-228 5.62e-04

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 41.62  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   49 TFVSLLGFMGN---LLILMAVMKKRNQKTTVNFligNLAFSDILVvLFCSPFTLTSVLLDQ-WMFGKAMCHIMPFLQCVS 124
Cdd:cd15922   8 SLVFLGGFLLNsfsLWIFWFRIKQWSSGTILQF---NLALSDAII-TPAAPLLIAYFSLGShWPFGQFLCQLKVFLLSTH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNNLTANHGYF--LIATVWTLGFAicSPLPVFHSLvelketfGSALLSSKYLCVESW 202
Cdd:cd15922  84 MYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMkkLCLGVWLLLFV--QGLPFFFVL-------KTSVIDGKTKCLSIH 154
                       170       180
                ....*....|....*....|....*....
gi 6981284  203 PSDSYRIAFTIS--LLLVQYILP-LVCLT 228
Cdd:cd15922 155 QSELSLLYFVWNfvLLILGFLLPfGVSLT 183
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
50-173 6.32e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 41.35  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15301   9 VLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASV 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6981284  130 LILISIAIVRYHMIKHPIS--NNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15301  89 LNLLIISFDRYFSVTRPLTyrARRTTKKAAVMIASAWIISLLLWPP 134
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
42-248 6.70e-04

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 41.28  E-value: 6.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFgsallSSKYLCVES 201
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPS-----NNETYCRSF 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6981284  202 WPSDSYR---IAFTISLLLVQYILPLVCLTVSHTSVCRSISCGlSHKENR 248
Cdd:cd14987 156 YPEESFKewlIGMELVSIVLGFVIPFPIIAVFYFLLARAISAS-SDQERK 204
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
54-173 7.11e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 41.32  E-value: 7.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   54 LGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVvLFCSPFTLTSVL-LDQWMFGKAMCHIMPFLQCVSVLVSTLIL 132
Cdd:cd15199  13 LGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLL-LICLPFKAYFYLnGNRWSLGGGTCKALLFMLSLSRGVSIAFL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6981284  133 ISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAICSP 173
Cdd:cd15199  92 TAVALDRYFRVVHPRgkKNSLSLQAAPYISFLVWLLLVGLTIP 134
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
55-182 1.85e-03

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 40.14  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   55 GFMGNLLILMAV-MKKRNQK----TTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFG----KAMCHIMPFLQCVSV 125
Cdd:cd15139  14 GVLGNVLALVLLeRRRRKEVgrrqSLFHVLVTSLVITDLLGTCLISPVVLASYSRNTTLVGmspnRLVCGYFGFAMTFFS 93
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  126 LVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICS-PLPVFHSLVE 182
Cdd:cd15139  94 LATMLILLAMALERCLSIGHPYFYEryVSKRCGYVTIPLIYLLCALFCLfPFLGFGKYVQ 153
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
360-428 1.96e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 39.82  E-value: 1.96e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981284  360 KRSRSVFYRLTILILVFAVSWMPLHV----FHVVTDFNDNLISNrhFKLVYCICHLLGMMSCCLNPILYGFLN 428
Cdd:cd15133 221 RTRAQVTKMLFILVVVFAICWAPFHIdrlmWSFISDWTDNLHEV--FQYVHIISGVFFYLSSAVNPILYNLMS 291
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
42-183 2.04e-03

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 39.62  E-value: 2.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15936   1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYF--LIATVWTLGFAicsplpvfHSLVEL 183
Cdd:cd15936  81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCtgLVAGSWLGGFA--------HSIVQV 136
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
42-240 2.18e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 39.76  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15365   1 YLFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANhgyflIATVWTLGFAICSPLPVFHSLVEL-KETFGSAllSSKYLCVE 200
Cdd:cd15365  81 YTNFYTSTALLTCIALDRYLAVVHPLKFMHLRT-----IRTALSVSVAIWLLEICFNAVILTwEDSFHES--SSHTLCYD 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6981284  201 SWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISC 240
Cdd:cd15365 154 KFPLEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRS 193
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
51-241 2.18e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 39.74  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   51 VSLLGFMGNLLILMAVMKKRNQKTTVnfLIGNLAFSDILVVLFCSPFTL--TSVLLDQWMFGKAMCHIMPFLQCVSVLVS 128
Cdd:cd15220   9 LDLTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIFLSVCLVSAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  129 TLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAIcSPLPVFHSLvelkeTFGSALLSSKYLCVESWPSDS 206
Cdd:cd15220  87 ILTISAISVERYYYIVHPMryEVKMTIGLVAAVLVGVWVKALLL-GLLPVLGWP-----SYGGPAPIAARHCSLHWSHSG 160
                       170       180       190
                ....*....|....*....|....*....|....*
gi 6981284  207 YRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCG 241
Cdd:cd15220 161 HRGVFVVLFALVCFLLPLLLILVVYCGVFKVFGGG 195
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
43-183 2.24e-03

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 39.78  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQC 122
Cdd:cd15370   2 FLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFY 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  123 VSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIA-TVWTLGFAICSPLPVFHSLVEL 183
Cdd:cd15370  82 GNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISlAIWLLILLVTIPLYLVKQTVFI 143
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
369-429 2.41e-03

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 39.69  E-value: 2.41e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  369 LTILILVFAVSWMPLHVFHVV-----TDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 429
Cdd:cd15922 213 IGISLVIFIICFVPLHVTRTVgvvvkLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASE 278
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
39-198 2.73e-03

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 39.66  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   39 DLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMP 118
Cdd:cd15406   7 ELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGFaICSplpVFHSLVELKETFGSALLSSKY 196
Cdd:cd15406  87 FFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRvcSLLVAGVYIMGL-IGA---TVHTSCMLRLSFCGDNVINHY 162

                ..
gi 6981284  197 LC 198
Cdd:cd15406 163 FC 164
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
355-428 2.74e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 2.74e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981284  355 ITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHllgmMSCCLNPILYGFLN 428
Cdd:cd15049 186 IYRETARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWSFGYWLCY----INSTINPFCYALCN 255
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
43-170 2.97e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 39.46  E-value: 2.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCspFTLTSVLLD----------QWMFGkA 112
Cdd:cd15359   2 FLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYL--LLIASVDSQtksqyynhaiDWQTG-S 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284  113 MCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFAI 170
Cdd:cd15359  79 GCSTAGFFTVFASELSVYTLTVITLERWHTITYAMqlDRKLRLRHAILIMLGGWVFSLLI 138
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-177 3.36e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 39.12  E-value: 3.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVST 129
Cdd:cd15081  21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGL 100
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  130 LILISIAIVRYHMIKHPISN-NLTANHGYFLIATVWTLGFAICSPlPVF 177
Cdd:cd15081 101 WSLTIISWERWVVVCKPFGNiKFDGKLAIVGIIFSWVWSAVWCAP-PIF 148
YejM COG3083
Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily [Cell wall ...
83-183 3.79e-03

Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225625 [Multi-domain]  Cd Length: 600  Bit Score: 39.72  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   83 LAFSDILVVLFcspfTLTSVLLDQWMFGkamchimpFLQ-CVSVLVSTLILISIAIV-RYHMIKHPISNNLTANHGYFLI 160
Cdd:COG3083  64 LVFALYLLVLF----PLTFIVLSQRLFR--------FLSvILSTAGMTLLLVDSEVFqRFNLHLNPVVWELLVNPEQSEM 131
                        90       100
                ....*....|....*....|...
gi 6981284  161 ATVWTLGFAicsPLPVFhSLVEL 183
Cdd:COG3083 132 SRDWQLLFA---SVPVI-LLLEL 150
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
42-168 3.84e-03

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 38.96  E-value: 3.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQ 121
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6981284  122 CVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGF 168
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVclWLVAALWLGGT 129
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
50-150 4.15e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 38.74  E-value: 4.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   50 FVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCspFTLTSVLLD----------QWMFGkAMCHIMPF 119
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYL--GLLAIVDAKtlgeyynyaiDWQTG-AGCKTAGF 85
                        90       100       110
                ....*....|....*....|....*....|.
gi 6981284  120 LQCVSVLVSTLILISIAIVRYHMIKHPISNN 150
Cdd:cd15136  86 LAVFSSELSVFTLTVITLERWYAITHAMHLN 116
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
372-427 4.26e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 38.90  E-value: 4.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  372 LILVFAVSWMPLHVFHVVTDFNDNLISNRH------FKLVYCICHLLGMMSCCLNPILYGFL 427
Cdd:cd15180 211 VVVVFFLCWTPYNIALLVDTLIDLSVLDRNcgtesrLDIALSVTSSLGYFHCCLNPLLYAFV 272
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
43-174 5.05e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 38.62  E-value: 5.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAV---MKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLD--QWMFGKAMCHIM 117
Cdd:cd15135   2 TLTLLYSLILVAGILGNSATIKVTqvlQKKGYLQKSVTDHMVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIY 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6981284  118 PFLQCVSVLVSTLILISIAIVRYHMIKHPI-SNNLTANHGYFLIATVWTLGFAICSPL 174
Cdd:cd15135  82 NFLFEACSYATILNVATLSFERYIAICHPFkYKALSGSRVRLLICFVWLTSALVALPL 139
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
43-169 6.02e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 38.39  E-value: 6.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDIlvvlFCSPFTLTSVLLDQWMFGKAM----CHIMP 118
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDI----ICTSTVVPKLLQNLLTERKTIsfggCMAQL 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981284  119 FLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGY--FLIATVWTLGFA 169
Cdd:cd15232  78 YFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVcvGLATGVWAIGML 130
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
48-147 6.60e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 38.34  E-value: 6.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLL--ILMAVMKKRNQKTTVNFLIGnLAFSDILVVLFCS--PFTLTSVLLDQWMfGKAMCHIMPFLQCV 123
Cdd:cd15919   7 YSLLLCLGLPANILtvIILSQLVARRQKSSYNYLLA-LAAADILVLFFIVfvDFLLEDFILNKQM-PQVLDKIIEVLEFS 84
                        90       100
                ....*....|....*....|....
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPI 147
Cdd:cd15919  85 SIHTSIWITVPLTIDRYIAVCHPL 108
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
48-177 6.78e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 38.20  E-value: 6.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAV---MKKRNQKTTVNFligNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVS 124
Cdd:cd15373   7 YGIVFVVGLVLNILALYVFlfrTKPWNASTTYMF---NLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981284  125 VLVSTLILISIAIVRYHMIKHPISNN--LTANHGYFLIATVWTLGFAICSPLPVF 177
Cdd:cd15373  84 LYCSILFLLCISVHRFLGVCYPVRSLrwLKVRYARIVSVVVWVIVLACQSPVLYF 138
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
373-435 6.82e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 38.22  E-value: 6.82e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981284  373 ILVFAVSWMPLHVFHVVTDFNDNLISnRHFKLV------YCICHLLGMMSCCLNPILYGFLNNGIKADL 435
Cdd:cd14988 211 ILVFVVCWLPYHVTLLLLTLHGSHIS-LHCNLVhflyffYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
43-168 7.15e-03

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 37.97  E-value: 7.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   43 FLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMChimpFLQ- 121
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRC----LAQm 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981284  122 CVSV-LVST--LILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGF 168
Cdd:cd15431  78 YISLfLGITecLLLAVMAYDRFVAICNPLRYTLIMSWRvcIQLAAGSWVSAF 129
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
42-183 7.27e-03

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 37.95  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   42 YFLIGLYTFVSLLgfMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWM--FGKAMCHIMpF 119
Cdd:cd15226   3 LFVFFSLFYVATV--LGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTisFGGCMAQIF-F 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6981284  120 LQCVSVlVSTLILISIAIVRYHMIKHPI--SNNLTANHGYFLIATVWTLGFaicsplpvFHSLVEL 183
Cdd:cd15226  80 LHFFGG-SEMVLLIAMAFDRYVAICKPLhyLTIMSPRMCILLVVASWIIGF--------IHSLSQL 136
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
46-177 7.72e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 7.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   46 GLYTFVSLLGFMGNLL---ILMAVMKKRNQKTTV-NFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFG----KAMCHIM 117
Cdd:cd15141   5 ATSTLMFAAGVVGNLLalgILGVHRKERRTKSSAfCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGlaagQPLCHLF 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981284  118 PFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIA--TVWTLGFAICSpLPVF 177
Cdd:cd15141  85 AFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLAlpAIYAFGALFCA-LPLL 145
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
59-176 7.90e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 37.93  E-value: 7.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   59 NLLILMAVMKKRNQKTTVNFLIGNLAFSDIL------VVLFCSPFTLTSVLLDQWMFGKAMCHimpflqcVSVLVSTLIL 132
Cdd:cd15346  18 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaytANLLLSGATTYKLTPTQWFLREGSMF-------VALSASVFSL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6981284  133 ISIAIVRY-HMIKHPISNNLTANHGYFLIATVWTLGfAICSPLPV 176
Cdd:cd15346  91 LAIAIERYiTMLKMKLHNGSNSFRSFLLISACWVIS-LILGGLPI 134
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
44-182 8.17e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 37.93  E-value: 8.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   44 LIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCV 123
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981284  124 SVLVSTLILISIAIVRYHMIKHPISNNLTANHG--YFLIATVWTLGFaicsplpvFHSLVE 182
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRlcWVLVAASWAGGF--------LHSIVQ 135
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
48-147 8.30e-03

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 37.82  E-value: 8.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981284   48 YTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLV 127
Cdd:cd16001   7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYG 86
                        90       100
                ....*....|....*....|
gi 6981284  128 STLILISIAIVRYHMIKHPI 147
Cdd:cd16001  87 SILFLTCISVHRFLGVCYPI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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