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leukemia inhibitory factor receptor isoform 1 precursor [Mus musculus]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
LIFR_D2 | pfam17971 | Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ... |
126-239 | 8.95e-61 | |||
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation. : Pssm-ID: 375455 Cd Length: 114 Bit Score: 202.68 E-value: 8.95e-61
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LIFR_N | pfam18207 | Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ... |
50-124 | 6.01e-35 | |||
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45. : Pssm-ID: 436347 Cd Length: 78 Bit Score: 127.82 E-value: 6.01e-35
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
428-525 | 2.43e-07 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. : Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.80 E-value: 2.43e-07
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
724-816 | 1.24e-04 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. : Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 1.24e-04
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FN3 super family | cl21522 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
547-614 | 2.66e-03 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. The actual alignment was detected with superfamily member pfam00041: Pssm-ID: 473895 [Multi-domain] Cd Length: 85 Bit Score: 37.78 E-value: 2.66e-03
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Name | Accession | Description | Interval | E-value | |||
LIFR_D2 | pfam17971 | Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ... |
126-239 | 8.95e-61 | |||
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation. Pssm-ID: 375455 Cd Length: 114 Bit Score: 202.68 E-value: 8.95e-61
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LIFR_N | pfam18207 | Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ... |
50-124 | 6.01e-35 | |||
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45. Pssm-ID: 436347 Cd Length: 78 Bit Score: 127.82 E-value: 6.01e-35
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
428-525 | 2.43e-07 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.80 E-value: 2.43e-07
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fn3 | pfam00041 | Fibronectin type III domain; |
431-515 | 4.04e-06 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.87 E-value: 4.04e-06
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FN3 | smart00060 | Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
431-506 | 3.21e-05 | |||
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins. Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 43.37 E-value: 3.21e-05
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
724-816 | 1.24e-04 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 1.24e-04
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fn3 | pfam00041 | Fibronectin type III domain; |
724-817 | 1.41e-04 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 41.63 E-value: 1.41e-04
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fn3 | pfam00041 | Fibronectin type III domain; |
547-614 | 2.66e-03 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 37.78 E-value: 2.66e-03
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Name | Accession | Description | Interval | E-value | |||
LIFR_D2 | pfam17971 | Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ... |
126-239 | 8.95e-61 | |||
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation. Pssm-ID: 375455 Cd Length: 114 Bit Score: 202.68 E-value: 8.95e-61
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LIFR_N | pfam18207 | Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ... |
50-124 | 6.01e-35 | |||
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45. Pssm-ID: 436347 Cd Length: 78 Bit Score: 127.82 E-value: 6.01e-35
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
428-525 | 2.43e-07 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.80 E-value: 2.43e-07
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fn3 | pfam00041 | Fibronectin type III domain; |
431-515 | 4.04e-06 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.87 E-value: 4.04e-06
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FN3 | smart00060 | Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
431-506 | 3.21e-05 | |||
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins. Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 43.37 E-value: 3.21e-05
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
724-816 | 1.24e-04 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 1.24e-04
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fn3 | pfam00041 | Fibronectin type III domain; |
724-817 | 1.41e-04 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 41.63 E-value: 1.41e-04
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fn3 | pfam00041 | Fibronectin type III domain; |
547-614 | 2.66e-03 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 37.78 E-value: 2.66e-03
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Blast search parameters | ||||
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