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Conserved domains on  [gi|153792131|ref|NP_038659|]
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pyruvate kinase PKLR isoform 1 [Mus musculus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 85-573 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 794.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 164
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 165 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 243
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 483
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 484 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 563
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792131 564 YTNIMRVLTI 573
Cdd:cd00288  471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 85-573 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 794.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 164
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 165 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 243
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 483
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 484 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 563
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792131 564 YTNIMRVLTI 573
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 86-570 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 668.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131   86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  166 VLQGGPeseVEIVKGSQVLVTVDPKFRTrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 324
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 484
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  485 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 563
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 153792131  564 YTNIMRV 570
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 86-573 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 635.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDE 325
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 326 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 405
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 406 GETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 485
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 486 RYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 564
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 153792131 565 TNIMRVLTI 573
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 85-438 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 601.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131   85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRT 164
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  165 GVLQGGPeSEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 243
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 153792131  404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLF 438
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 86-557 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 533.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGPeseVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 324
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSAQL 483
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792131 484 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAVWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 557
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 85-573 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 794.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 164
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 165 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 243
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 483
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 484 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 563
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792131 564 YTNIMRVLTI 573
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 86-570 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 668.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131   86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  166 VLQGGPeseVEIVKGSQVLVTVDPKFRTrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 324
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 484
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  485 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 563
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 153792131  564 YTNIMRV 570
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 86-573 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 635.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDE 325
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 326 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 405
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 406 GETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 485
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 486 RYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 564
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 153792131 565 TNIMRVLTI 573
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 85-438 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 601.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131   85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRT 164
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  165 GVLQGGPeSEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 243
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 153792131  404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLF 438
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 86-557 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 533.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGPeseVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 324
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSAQL 483
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792131 484 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAVWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 557
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 88-555 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 524.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfaTSPLSyrpvAIALDTKGPEIRTGVL 167
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN--TGILC----AVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 168 Q-GGPeseVEIVKGSQVLVTVDpkFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVT-EVEHGG 244
Cdd:PLN02461  97 KdGKP---VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEaGTVRcRCENSA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 245 FLGNRKGVNLPNAEVDLPGLSEQDLLD-LRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 323
Cdd:PLN02461 172 MLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNF 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 324 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 403
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 404 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 483
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 484 LSRYRPRAAVIAV------TRSAQ-------AARQVHLSRGVFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGD 550
Cdd:PLN02461 412 VAKYRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGD 491


                 ....*
gi 153792131 551 LVIVV 555
Cdd:PLN02461 492 SVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
86-570 8.58e-172

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 495.34  E-value: 8.58e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplSYRPVAIALDTKGPEIRTG 165
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSK------TGKKAAILLDTKGPEIRTM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGpeSEVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 245
Cdd:PRK09206  76 KLEGG--NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 246 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPE-GRGIKIISKIENHEGVKKFD 324
Cdd:PRK09206 152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRqlFEELRRAAPLsrDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 484
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSR--LESNNDNRKL--RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 485 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPpeavwaDDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 564
Cdd:PRK09206 388 RKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI------ASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGT 461


                 ....*.
gi 153792131 565 TNIMRV 570
Cdd:PRK09206 462 TNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 86-574 2.71e-169

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 493.29  E-value: 2.71e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 165
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLG------KTVGILQDLQGPKIRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 166 VLQGGPeseVEIVKGSQVLVTVDPKfrtRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEG--LVTEVEHG 243
Cdd:PRK06354  82 RFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 244 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPE-GRGIKIISKIENHEGVKK 322
Cdd:PRK06354 156 GVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 323 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCI 402
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 403 MLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplsrDPTEVTAIG-AV-EASFKCCAAAIIVLTKTGRS 480
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF-----TTTITNAISqAVsHIALQLDAAAIVTLTKSGAT 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 481 AQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvwaddvDRRVQFGIESGKLRGFLRVGDLVIVVTGWRP 560
Cdd:PRK06354 391 ARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPST------DETFDAAINVAQESGLLKQGDLVVITAGTLV 464

                        490
                 ....*....|....*
gi 153792131 561 G-SGYTNIMRVLTIS 574
Cdd:PRK06354 465 GeSGSTDLMKVHVVG 479
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 112-574 3.50e-168

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 485.32  E-value: 3.50e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 112 MNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRTGVLQGGpesEVEIVKGSQVLVTVDPKF 191
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 192 RTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLL 270
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 271 DLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVF 350
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 351 LAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEA 430
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 431 AVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSR 510
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792131 511 GVFPLLYrePPEAVWADD-VDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLTIS 574
Cdd:PTZ00300 392 GVESVFF--DAERLGHDEgKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 63-573 4.72e-167

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 484.65  E-value: 4.72e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  63 AAMADTFLEHLCL-LDIDSEPVA-----ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIRE 136
Cdd:PTZ00066   9 SVMGCSLGKATNIsLDKILEPISdndlrQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 137 AAESfatsplsyRP---VAIALDTKGPEIRTGVLQGGpeSEVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAV 213
Cdd:PTZ00066  89 AAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 214 GGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLD-LRFGVEHNVDIIFASFVRKAS 292
Cdd:PTZ00066 157 GNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSAD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 293 DVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQ 372
Cdd:PTZ00066 237 DVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQ 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 373 MLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPT 452
Cdd:PTZ00066 317 MLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQ 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 453 EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRR 532
Cdd:PTZ00066 397 EAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS------FQGTDVV 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 153792131 533 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVLTI 573
Cdd:PTZ00066 471 IRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
PRK06247 PRK06247
pyruvate kinase; Provisional
 85-574 2.57e-137

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 407.39  E-value: 2.57e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 164
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETG------RPIGILADLQGPKLRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 165 GVLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGG 244
Cdd:PRK06247  78 GRFADGK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 245 FLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDAlgpEGRGIKIISKIENHEGVKKFD 324
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 325 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 404
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 405 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEelrraapLSRDPTEVTAIGAVEASFKCCA-----AAIIVLTKTGR 479
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLIH-------AQRPQPEATKRDAISYAARDIAerldlAALVAYTSSGD 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 480 SAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLyrePPEAVWADDVDRRVQfgiESGKLRGFLRVGDLVIVVTGWR 559
Cdd:PRK06247 382 TALRAARERPPLPILALTPNPETARRLALTWGVHCVV---VDDARDTDDMVRRAD---RIALAEGFYKRGDRVVIVAGVP 455

                        490
                 ....*....|....*.
gi 153792131 560 PG-SGYTNIMRVLTIS 574
Cdd:PRK06247 456 PGtPGSTNMLRIAYIG 471
PLN02765 PLN02765
pyruvate kinase
 88-554 1.12e-108

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 335.49  E-value: 1.12e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplSYRPVAIALDTKGPEIrtGVL 167
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPEL--QVI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 168 QGgPESEVEIVKGSQVLVTVDPKfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLIS--------LVVRKIGPEGLVTE 239
Cdd:PLN02765 102 NK-TEKPISLKAGNTVTLTPDQS--KEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 240 VEHGGFL-GNRKGVNLPNAEVDLPGLSEQDLLDLR-FGVEHNVDIIFASFVRKASDVVAVRDALGPEG-RGIKIISKIEN 316
Cdd:PLN02765 179 VKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIEN 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 317 HEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVcATQMLESMITKARPTRAETSDVANAVL 396
Cdd:PLN02765 259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVL 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 397 DGADCIMLSGETAKGSFPVEAVKMQHAIAREAEaAVYHRQLFeeLRRAAPLSRDP---TEVTAIGAVEASFKCCAAAIIV 473
Cdd:PLN02765 338 DGADAILLGAETLRGLYPVETISTVGRICAEAE-KVFNQDLY--FKKTVKYVGEPmshLESIASSAVRAAIKVKASVIIV 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 474 LTKTGRSAQLLSRYRPRAAVIAVT-------------RSAQAARQVHLSRGVFPLLY--REPPEAVWADDvDRRVQFGIE 538
Cdd:PLN02765 415 FTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLAdpRHSAESTSATN-ESVLKVALD 493

                        490
                 ....*....|....*.
gi 153792131 539 SGKLRGFLRVGDLVIV 554
Cdd:PLN02765 494 HGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 14-569 1.32e-98

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 311.09  E-value: 1.32e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  14 PWIFKSQKDLAKSALSGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSE--------PVAA 85
Cdd:PLN02623  30 PLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDGGANFVEDNEEVLLEIQQLGEtavgmwskPSVR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  86 RSTSIIATIGPASRSvdrlKEMI----KAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPlsyrpVAIALDTKGPE 161
Cdd:PLN02623 110 RKTKIVCTIGPSTNT----REMIwklaEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV-----IAIMLDTKGPE 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 162 IRTGVLqggPESeVEIVKGSQVLVTVDpkfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVE 241
Cdd:PLN02623 181 VRSGDL---PQP-IMLEEGQEFTFTIK---RGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVV 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 242 HGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVK 321
Cdd:PLN02623 254 DGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIP 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 322 KFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADC 401
Cdd:PLN02623 334 NLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADA 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 402 IMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAplsrdPTEVTAIGAVEASF--KCCAAAIIVLTKTGR 479
Cdd:PLN02623 414 VMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAF-----KNHMSEMFAFHATMmaNTLGTSIIVFTRTGF 488

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 480 SAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPlLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTgwr 559
Cdd:PLN02623 489 MAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-----FSDDAEETFARALSLLLNKGMVKEGEEVALVQ--- 559

                        570
                 ....*....|
gi 153792131 560 pgSGYTNIMR 569
Cdd:PLN02623 560 --SGRQPIWR 567
PRK06739 PRK06739
pyruvate kinase; Validated
 91-429 2.46e-92

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 287.61  E-value: 2.46e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  91 IATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplsyrpVAIALDTKGPEIRTGVLQGg 170
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 171 peSEVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRK 250
Cdd:PRK06739  75 --EQITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 251 GVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGR-GIKIISKIENHEGVKKFDEILEV 329
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKEtSPNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 330 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETA 409
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 153792131 410 KGSFPVEAVKMQHAIAREAE 429
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 85-574 1.78e-90

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 287.80  E-value: 1.78e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  85 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIRE--AAESFAtsplsyrpVAIALDTKGPEI 162
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA--------VAVMMDTEGSEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 163 RTGVLQGGPESEVEivKGSQVLVTVDpKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISL-VVRKIGPE------- 234
Cdd:PLN02762  96 HMGDLGGASSAKAE--DGEEWTFTVR-KFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPDvkckctd 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 235 -GLVTEVEHGGFLGNRKGVNLPNAEvdLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG--IKII 311
Cdd:PLN02762 173 pGLLLPRANLTFWRDGSLVRERNAM--LPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVI 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 312 SKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV 391
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 392 ANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRR---AAPLSRDPTEVTAIGAVEASFKCCA 468
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGV 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 469 AAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYReppeavWADDVDRRVQFGIESGKLRGFLRV 548
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD------FSDDMESNLNKTFSLLKARGMIKS 484

                        490       500
                 ....*....|....*....|....*.
gi 153792131 549 GDLVIVVTGWRPGSGYTNImRVLTIS 574
Cdd:PLN02762 485 GDLVIAVSDLTPSSMLQSI-QVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 81-418 2.99e-55

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 194.08  E-value: 2.99e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  81 EPVAARSTSIIATI-GPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAEsfATSplsyRPVAIALDTKG 159
Cdd:PRK08187 128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAER--ATG----RRCKILMDLAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 160 PEIRTGVLqGGPESEVEIVKGSQVLVTVDPKF-RTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVT 238
Cdd:PRK08187 202 PKIRTGAV-AGPLGKTRLYTGDRLALVAQGPPrRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 239 EVEHGGFLGNR----KGVNLPNAEVDLPGLSEQDLLDLRFGVEHnVDIIFASFVRKASDVVAVRDAL---GPEGRG-IKI 310
Cdd:PRK08187 281 EVTHARPKGLKlkpeKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALaarRPDDWRkLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 311 ISKIENHEGVKKFDEILEVSDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTR 385
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350
                 ....*....|....*....|....*....|...
gi 153792131 386 AETSDVANAvlDGADCIMLSgetaKGSFPVEAV 418
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 57-443 3.50e-44

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 165.89  E-value: 3.50e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  57 QQQQLPAAMADTFLEHLCLLDIDSE-----PVAARSTSIIATIgPASRSVDR--LKEMIKAGMNIARLNFSHGSHEYHAE 129
Cdd:PRK14725 105 GPAYPPEDTAVTFEEGDELLDEHAEallgpPPSGRPTRIMVTL-PTEAADDPdlVRRLLAAGMDIARINCAHDDPEAWRA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 130 SIANIREAAESFAtsplsyRPVAIALDTKGPEIRTGVLQGGPE-----------------SEVEIVKGS---------QV 183
Cdd:PRK14725 184 MIANVRTAEEELG------RRCRIAMDLAGPKLRTGPIAPGPRviklrptrdalgrvltpARLWLTASEspppspppgPV 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 184 LVTVDPKF-------------RTRGDAK--------------------------TVWVDYHNITQV-------------- 210
Cdd:PRK14725 258 GLPVDPEWlarlepgdelrftDARGKKRkltvtevddegvlaegsqtaylangtLLRLGRHDSTRVgglppveqklrlkv 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 211 -----------------------------------VAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNR----KG 251
Cdd:PRK14725 338 gdrlvltrddapgdpaqgdapparisctlpeafraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKG 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 252 VNLPNAEVDLPGLSEQDLLDLRFGVEHnVDIIFASFVRKASDVVAVRDALGPEG-RGIKIISKIENHEGVKKFDEIL--- 327
Cdd:PRK14725 418 INLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGaDDLGVVLKIETRRAFENLPRILlea 496

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 328 --EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLdgADCIMLS 405
Cdd:PRK14725 497 mrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN 574

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 153792131 406 getaKGSFPVEAVKMQHAIAREAEAavYHRQLFEELRR 443
Cdd:PRK14725 575 ----KGPHIVEAVRVLDDILRRMEE--HQRKKRSLLRR 606
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
359-574 1.75e-40

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 149.28  E-value: 1.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 359 RCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRqlf 438
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYR--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131 439 eELRRAAPLSRDPTEVTAIG------AVEASfkccAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGV 512
Cdd:COG3848   78 -EQRVPRAKESSTTITDAIShavattAADLG----AAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792131 513 FPLLYREPPEAVwaDDVDRRVQFGIESgklrGFLRVGDLVIVVTGWRPG-SGYTNIMRVLTIS 574
Cdd:COG3848  153 YPLLVEESASTD--EMFAVAVALALEA----GLVKDGDLVVITAGVPVGvSGTTNLLKVHVVG 209
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 453-571 3.12e-35

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 128.37  E-value: 3.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792131  453 EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRR 532
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 153792131  533 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVL 571
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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