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Conserved domains on  [gi|7305585|ref|NP_038721|]
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tumor necrosis factor isoform 1 [Mus musculus]

Protein Classification

TNF domain-containing protein( domain architecture ID 10446394)

TNF domain-containing protein similar to Homo sapiens tumor necrosis factor, which acts as cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TNF pfam00229
TNF(tumor Necrosis Factor) family;
105-235 1.15e-50

TNF(tumor Necrosis Factor) family;


:

Pssm-ID: 425540  Cd Length: 127  Bit Score: 160.94  E-value: 1.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585    105 LEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCP-DYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDT 183
Cdd:pfam00229   1 LSWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPsGSVPLTHYLYKFSSSYPGPVLLLKGAESPCSSEN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7305585    184 PEGaelkpWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL 235
Cdd:pfam00229  81 PEY-----WYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSAPGKTYFGAFLL 127
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(tumor Necrosis Factor) family;
105-235 1.15e-50

TNF(tumor Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 160.94  E-value: 1.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585    105 LEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCP-DYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDT 183
Cdd:pfam00229   1 LSWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPsGSVPLTHYLYKFSSSYPGPVLLLKGAESPCSSEN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7305585    184 PEGaelkpWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL 235
Cdd:pfam00229  81 PEY-----WYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSAPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
91-233 3.78e-40

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 134.78  E-value: 3.78e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585   91 PVAHVVANHQ--VEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQgCPDYVLLTHTVSRFAISYQEK 168
Cdd:cd00184   1 PAAHLIGTNSssGGTGLSWESDDGRAFLSGGLELQNGELVVPQDGLYYIYSQVYFRGQ-CCSTLSVSHVLQLRTDSYPEP 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7305585  169 VNLLSAVKSPCPkdtpegAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAEsGQVYFGVI 233
Cdd:cd00184  80 ILLLKGIRSVCS------SVSEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQ-GTTFFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
105-235 2.91e-39

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 132.09  E-value: 2.91e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585     105 LEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCPDYVL-LTHTVSRFAISYQEKVNLLSAVKSPCPkdt 183
Cdd:smart00207   1 LSWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVeLSLSLHLRKPSYPLPLLLLEAARSSCW--- 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 7305585     184 pegAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAEsGQVYFGVIAL 235
Cdd:smart00207  78 ---SASSAWKDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAP-GATFFGAFLV 125
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(tumor Necrosis Factor) family;
105-235 1.15e-50

TNF(tumor Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 160.94  E-value: 1.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585    105 LEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCP-DYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDT 183
Cdd:pfam00229   1 LSWESDRGGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPsGSVPLTHYLYKFSSSYPGPVLLLKGAESPCSSEN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7305585    184 PEGaelkpWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL 235
Cdd:pfam00229  81 PEY-----WYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSAPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
91-233 3.78e-40

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 134.78  E-value: 3.78e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585   91 PVAHVVANHQ--VEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQgCPDYVLLTHTVSRFAISYQEK 168
Cdd:cd00184   1 PAAHLIGTNSssGGTGLSWESDDGRAFLSGGLELQNGELVVPQDGLYYIYSQVYFRGQ-CCSTLSVSHVLQLRTDSYPEP 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7305585  169 VNLLSAVKSPCPkdtpegAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAEsGQVYFGVI 233
Cdd:cd00184  80 ILLLKGIRSVCS------SVSEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQ-GTTFFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
105-235 2.91e-39

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 132.09  E-value: 2.91e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305585     105 LEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCPDYVL-LTHTVSRFAISYQEKVNLLSAVKSPCPkdt 183
Cdd:smart00207   1 LSWESDRGLASLLSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNGKSVeLSLSLHLRKPSYPLPLLLLEAARSSCW--- 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 7305585     184 pegAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAEsGQVYFGVIAL 235
Cdd:smart00207  78 ---SASSAWKDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAP-GATFFGAFLV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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