NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|31543845|ref|NP_038791|]
View 

transducin beta-like protein 2 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-393 4.68e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 4.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  74 THPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVW 150
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 151 LANGDTLRVFKMTKREDgGFTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNS 229
Cdd:COG2319 180 GSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 230 HAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyk 309
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 310 kqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG- 387
Cdd:COG2319 319 ---TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSa 392


                ....*.
gi 31543845 388 DRAVRL 393
Cdd:COG2319 393 DGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-393 4.68e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 4.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  74 THPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVW 150
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 151 LANGDTLRVFKMTKREDgGFTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNS 229
Cdd:COG2319 180 GSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 230 HAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyk 309
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 310 kqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG- 387
Cdd:COG2319 319 ---TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSa 392


                ....*.
gi 31543845 388 DRAVRL 393
Cdd:COG2319 393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-394 5.76e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 5.76e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  78 LAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 156
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 157 LRVFKMTKREDgGFTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISP 235
Cdd:cd00200  75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 236 CSRFVGSCGFTPDVKVWEVcfgKKGEFQEVlrafeLKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpy 315
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 316 lLRTGRFEEAStmPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRL 393
Cdd:cd00200 212 -LGTLRGHENG--VNSVAFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRI 287


                .
gi 31543845 394 F 394
Cdd:cd00200 288 W 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 82-114 3.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 3.07e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 31543845     82 LKSHSGNISCMDFSSNGKYLATCADDRTVRIWS 114
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
82-114 7.91e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 7.91e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 31543845    82 LKSHSGNISCMDFSSNGKYLATCADDRTVRIWS 114
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-393 4.68e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 4.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  74 THPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVW 150
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 151 LANGDTLRVFKMTKREDgGFTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNS 229
Cdd:COG2319 180 GSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 230 HAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyk 309
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 310 kqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG- 387
Cdd:COG2319 319 ---TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSa 392


                ....*.
gi 31543845 388 DRAVRL 393
Cdd:COG2319 393 DGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
76-404 2.79e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.79e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  76 PLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWStkdfLQREHRSMRANVELDHATLVRFSPDCRaFIVWLANGD 155
Cdd:COG2319  68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD----LATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 156 TLRVFKMTKREDGGfTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVIS 234
Cdd:COG2319 143 TVRLWDLATGKLLR-TLTG--------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 235 PCSRFVGSCGFTPDVKVWEVcfgKKGEFQevlraFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDP 314
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDL---ATGKLL-----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-------TG 278

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 315 YLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVR 392
Cdd:COG2319 279 ELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSdDGTVR 355

                       330       340
                ....*....|....*....|
gi 31543845 393 LF--------HNTPGHRAVV 404
Cdd:COG2319 356 LWdlatgellRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
78-305 4.65e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 4.65e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  78 LAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDflQREHRSMRANVELDHAtlVRFSPDCRafivWLANGD-- 155
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRS--VAFSPDGR----LLASGSad 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 156 -TLRVFKMTkredggftfTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVI 233
Cdd:COG2319 268 gTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAF 338

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31543845 234 SPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTD 305
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDL------ATGELLR--TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-394 5.76e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 5.76e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  78 LAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 156
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 157 LRVFKMTKREDgGFTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISP 235
Cdd:cd00200  75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 236 CSRFVGSCGFTPDVKVWEVcfgKKGEFQEVlrafeLKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpy 315
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 316 lLRTGRFEEAStmPCRLALSPDTHVLALATGTN-IHLFNTRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRL 393
Cdd:cd00200 212 -LGTLRGHENG--VNSVAFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRI 287


                .
gi 31543845 394 F 394
Cdd:cd00200 288 W 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 82-303 1.11e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  82 LKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQRehRSMRANveLDHATLVRFSPDcRAFI----------VWl 151
Cdd:cd00200  89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLRGH--TDWVNSVAFSPD-GTFVasssqdgtikLW- 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 152 aNGDTLRVFKmtkredggfTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSH 230
Cdd:cd00200 163 -DLRTGKCVA---------TLTG--------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNS 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31543845 231 AVISPCSRFVGSCGFTPDVKVWEVCFGKkgefqevlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 303
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
93-399 9.22e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 9.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  93 DFSSNGKYLATCADDRTVRIWstkdFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTF 172
Cdd:COG2319   1 ALSADGAALAAASADLALALL----AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 173 tatpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAV-ISPCSRFVGSCGFTPDVKV 251
Cdd:COG2319  77 ----------HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRL 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 252 WEVCFGKkgefqeVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCR 331
Cdd:COG2319 147 WDLATGK------LLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRS 209

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845 332 LALSPDTHVLALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 399
Cdd:COG2319 210 VAFSPDGKLLASGSADGtVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSaDGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
78-215 4.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 4.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543845  78 LAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDflQREHRSMRANVelDHATLVRFSPDCRaFIVWLANGDTL 157
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHT--GAVRSVAFSPDGK-TLASGSDDGTV 354

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31543845 158 RVFKMTKREDGGfTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLKG 215
Cdd:COG2319 355 RLWDLATGELLR-TLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 82-114 3.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 3.07e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 31543845     82 LKSHSGNISCMDFSSNGKYLATCADDRTVRIWS 114
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
82-114 7.91e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 7.91e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 31543845    82 LKSHSGNISCMDFSSNGKYLATCADDRTVRIWS 114
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-303 2.65e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.65e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 31543845    269 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 303
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
270-303 6.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 6.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 31543845   270 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 303
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH