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Conserved domains on  [gi|34328449|ref|NP_038901|]
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sulfotransferase 4A1 isoform 1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 4.89e-69

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 214.13  E-value: 4.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449    45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240
                         250
                  ....*....|...
gi 34328449   265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 4.89e-69

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 214.13  E-value: 4.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449    45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240
                         250
                  ....*....|...
gi 34328449   265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
21-215 1.41e-22

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 95.37  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   21 EFHGVR-LPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164  54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164 134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 34328449  166 MndklGYGSWFEHVQEFWEHRMDA--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164 211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 4.89e-69

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 214.13  E-value: 4.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449    45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240
                         250
                  ....*....|...
gi 34328449   265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
21-215 1.41e-22

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 95.37  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   21 EFHGVR-LPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164  54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164 134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 34328449  166 MndklGYGSWFEHVQEFWEHRMDA--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164 211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
Sulfotransfer_3 pfam13469
Sulfotransferase family;
50-216 4.26e-09

Sulfotransferase family;


Pssm-ID: 433234 [Multi-domain]  Cd Length: 173  Bit Score: 54.60  E-value: 4.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449    50 IVTYPKSGTSLLQEVVylvsqGADPDEIG---LMNIDEQLPVLeYPQPGLDIIKELT------SPRLIK---SHLPY--- 114
Cdd:pfam13469   3 IVGLPRSGTTLLHRLL-----AAHPDVRPpeeTWFVIPRILAL-LQAWGKSFILEALarvpsyARWLCDkspSHLFHldl 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328449   115 --RFLPsdlhngDSKVIYMARNPKDLVVS-YYQFHRSLRTmSYRGTFQEfcrrfmNDKLGYgsWFEHVQEFWEHRM---D 188
Cdd:pfam13469  77 llKAFP------DAKFIHLHRDPVDTVISsYCSLFGFTLS-SYSTDFDG------ADALAR--WSRAYERLMAARArvpP 141
                         170       180
                  ....*....|....*....|....*...
gi 34328449   189 ANVLFLKYEDMHRDLVTMVEQLARFLGV 216
Cdd:pfam13469 142 GRFLDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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