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Conserved domains on  [gi|7662034|ref|NP_055660|]
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polyphosphoinositide phosphatase [Homo sapiens]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 10493136)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 93-423 3.10e-118

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


:

Pssm-ID: 460545  Cd Length: 295  Bit Score: 361.89  E-value: 3.10e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034     93 FGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVT-----HPDEARYLRIFQNVDLSSNFYFSY 167
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQlakkeHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    168 SYDLSHSLQYNltvlrmplemlkseMTQNRQESFDIFEdeglitqggsgvfgicsepyMKYVWNGELL-DIIKSTV-HRD 245
Cdd:pfam02383  81 DYDLTNSLQRN--------------LTRSRSPSFDSLD--------------------DRFFWNRHLLkPLIDFQLdLDR 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    246 WLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASvmSFTAGSYSSYVQVR 325
Cdd:pfam02383 127 WILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLNT--SNSEGKIFSFVQIR 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    326 GSVPLYWSQDISTMMpKPPITLDQADPFAHVAALHFDQMFQRFGsPIIILNLVkerEKRKHERILSEELVAAVTYLNQFL 405
Cdd:pfam02383 205 GSIPLFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL 279

                         330
                  ....*....|....*...
gi 7662034    406 PPEhtIVYIPWDMAKYTK 423
Cdd:pfam02383 280 PDK--LRYTAFDFHHECK 295
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 93-423 3.10e-118

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 361.89  E-value: 3.10e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034     93 FGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVT-----HPDEARYLRIFQNVDLSSNFYFSY 167
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQlakkeHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    168 SYDLSHSLQYNltvlrmplemlkseMTQNRQESFDIFEdeglitqggsgvfgicsepyMKYVWNGELL-DIIKSTV-HRD 245
Cdd:pfam02383  81 DYDLTNSLQRN--------------LTRSRSPSFDSLD--------------------DRFFWNRHLLkPLIDFQLdLDR 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    246 WLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASvmSFTAGSYSSYVQVR 325
Cdd:pfam02383 127 WILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLNT--SNSEGKIFSFVQIR 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    326 GSVPLYWSQDISTMMpKPPITLDQADPFAHVAALHFDQMFQRFGsPIIILNLVkerEKRKHERILSEELVAAVTYLNQFL 405
Cdd:pfam02383 205 GSIPLFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL 279

                         330
                  ....*....|....*...
gi 7662034    406 PPEhtIVYIPWDMAKYTK 423
Cdd:pfam02383 280 PDK--LRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
14-636 6.69e-91

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 299.30  E-value: 6.69e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034   14 KLVLYEtRARYFLVGSNNAETKYRVLKIDRTEpkdlviiddrhvytqqevRELLGRLDLGNRTkMGQKGSSGLFRAVSAF 93
Cdd:COG5329   2 QCFLGE-KPRSIAIVSNNYALSFRRLGVKNSE------------------RILCATELVGVRF-EPDEGFSSLSSAHKIY 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034   94 GVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVR-VTHPDEARYLRIFQNVDLSSN--FYFSYSYD 170
Cdd:COG5329  62 GVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDdELEEDEANYDKLSELKKLLSNgtFYFSYDFD 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  171 LSHSLQYNLTVLRMPlemlkSEMTQNRQESFDIFEDEGLITqggsgvfgicsepymkyvWNGELLDIIKSTvhRDWLLYI 250
Cdd:COG5329 142 ITNSLQKNLSEGLEA-----SVDRADLIFMWNSFLLEEFIN------------------HRSKLSSLEKQF--DNFLTTV 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  251 IHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVmsftagsYSSYVQVRGSVPL 330
Cdd:COG5329 197 IRGFAETVDIKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQY-------IFSFTQVRGSIPL 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  331 YWSQDISTMMPKPPITlDQADPFAHVAALHFDQMFQRFGsPIIILNLV--KEREKRKHERIlsEELVAavtyLNQFLPpe 408
Cdd:COG5329 270 FWEQSNLLYGPKIKVT-RSSEAAQSAFDKHFDKLREKYG-DVYVVNLLktKGYEAPLLELY--EKHLD----LSKKPK-- 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  409 htIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFvnrpdsycsilrpdekwnelgGCVIPTGRL---QTGILRTN 485
Cdd:COG5329 340 --IHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYF---------------------AYDINEGKSiseQDGVFRTN 396

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  486 CVDCLDRTNTAQFMVGKcALAYQLYSLGLIDKPNLQFDTDavrlFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQ 565
Cdd:COG5329 397 CLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGYSPFLQI----HRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAG 471

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662034  566 HSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPhlwelptDFYLHhkntMRLLPTR--RSYTYWWT 636
Cdd:COG5329 472 ALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFS-------YRPLR----ITFLLLMitACTISWFS 533
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 93-423 3.10e-118

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 361.89  E-value: 3.10e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034     93 FGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVT-----HPDEARYLRIFQNVDLSSNFYFSY 167
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQlakkeHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    168 SYDLSHSLQYNltvlrmplemlkseMTQNRQESFDIFEdeglitqggsgvfgicsepyMKYVWNGELL-DIIKSTV-HRD 245
Cdd:pfam02383  81 DYDLTNSLQRN--------------LTRSRSPSFDSLD--------------------DRFFWNRHLLkPLIDFQLdLDR 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    246 WLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASvmSFTAGSYSSYVQVR 325
Cdd:pfam02383 127 WILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLNT--SNSEGKIFSFVQIR 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034    326 GSVPLYWSQDISTMMpKPPITLDQADPFAHVAALHFDQMFQRFGsPIIILNLVkerEKRKHERILSEELVAAVTYLNQFL 405
Cdd:pfam02383 205 GSIPLFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL 279

                         330
                  ....*....|....*...
gi 7662034    406 PPEhtIVYIPWDMAKYTK 423
Cdd:pfam02383 280 PDK--LRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
14-636 6.69e-91

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 299.30  E-value: 6.69e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034   14 KLVLYEtRARYFLVGSNNAETKYRVLKIDRTEpkdlviiddrhvytqqevRELLGRLDLGNRTkMGQKGSSGLFRAVSAF 93
Cdd:COG5329   2 QCFLGE-KPRSIAIVSNNYALSFRRLGVKNSE------------------RILCATELVGVRF-EPDEGFSSLSSAHKIY 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034   94 GVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVR-VTHPDEARYLRIFQNVDLSSN--FYFSYSYD 170
Cdd:COG5329  62 GVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDdELEEDEANYDKLSELKKLLSNgtFYFSYDFD 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  171 LSHSLQYNLTVLRMPlemlkSEMTQNRQESFDIFEDEGLITqggsgvfgicsepymkyvWNGELLDIIKSTvhRDWLLYI 250
Cdd:COG5329 142 ITNSLQKNLSEGLEA-----SVDRADLIFMWNSFLLEEFIN------------------HRSKLSSLEKQF--DNFLTTV 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  251 IHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVmsftagsYSSYVQVRGSVPL 330
Cdd:COG5329 197 IRGFAETVDIKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQY-------IFSFTQVRGSIPL 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  331 YWSQDISTMMPKPPITlDQADPFAHVAALHFDQMFQRFGsPIIILNLV--KEREKRKHERIlsEELVAavtyLNQFLPpe 408
Cdd:COG5329 270 FWEQSNLLYGPKIKVT-RSSEAAQSAFDKHFDKLREKYG-DVYVVNLLktKGYEAPLLELY--EKHLD----LSKKPK-- 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  409 htIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFvnrpdsycsilrpdekwnelgGCVIPTGRL---QTGILRTN 485
Cdd:COG5329 340 --IHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYF---------------------AYDINEGKSiseQDGVFRTN 396

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662034  486 CVDCLDRTNTAQFMVGKcALAYQLYSLGLIDKPNLQFDTDavrlFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQ 565
Cdd:COG5329 397 CLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGYSPFLQI----HRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAG 471

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662034  566 HSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPhlwelptDFYLHhkntMRLLPTR--RSYTYWWT 636
Cdd:COG5329 472 ALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFS-------YRPLR----ITFLLLMitACTISWFS 533
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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