NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|57163987|ref|NP_055878|]
View 

sodium/calcium exchanger 2 precursor [Homo sapiens]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1615.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987     1 MAPLALVGVTLLLAAPPCSGAATPTPSLPPppANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    81 YMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   161 GPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGAEapGELGGLGPGPAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSH--VDNFLDGALVLEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   318 ILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAE--GAGEDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHevATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   396 IFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GDGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   633 RKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAgDEEEEEDG 712
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA-GDDDDDDE 719

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   713 SREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALG 792
Cdd:TIGR00845 720 DGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALG 799

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   793 TSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAV 872
Cdd:TIGR00845 800 TSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGV 879

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*....
gi 57163987   873 LLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
Cdd:TIGR00845 880 LLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1615.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987     1 MAPLALVGVTLLLAAPPCSGAATPTPSLPPppANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    81 YMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   161 GPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGAEapGELGGLGPGPAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSH--VDNFLDGALVLEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   318 ILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAE--GAGEDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHevATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   396 IFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GDGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   633 RKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAgDEEEEEDG 712
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA-GDDDDDDE 719

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   713 SREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALG 792
Cdd:TIGR00845 720 DGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALG 799

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   793 TSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAV 872
Cdd:TIGR00845 800 TSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGV 879

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*....
gi 57163987   873 LLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
Cdd:TIGR00845 880 LLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-379 3.34e-74

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 239.52  E-value: 3.34e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 57163987   324 QKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRA 379
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 393-483 2.08e-35

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 129.30  E-value: 2.08e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGeGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIF 472
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 57163987    473 EEDEHFFVRLL 483
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
748-909 3.89e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 3.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 748 GWACFGVSILVIG--LLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 825
Cdd:COG0530 155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 826 VFLGLGvawsVAAVYwavqgrpfevRTGTLAFSVTLFTVFAFVGIAVLLY--RRRphiGGELGGPRGpklattALFLGLW 903
Cdd:COG0530 230 ILLVLG----IGALI----------TPIPVDPAVLSFDLPVMLAATLLLLglLRT---GGRIGRWEG------LLLLALY 286


                ....*.
gi 57163987 904 LLYILF 909
Cdd:COG0530 287 LAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 752-855 5.36e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 46.18  E-value: 5.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987  752 FGVSILVIGLLTALIGD-----LASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNV 826
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81

                         90       100
                 ....*....|....*....|....*....
gi 57163987  827 FLGLGVAWSVaavywavqgRPFEVRTGTL 855
Cdd:PRK10734  82 LLILGLAALI---------RPFTVHSDVL 101
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1615.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987     1 MAPLALVGVTLLLAAPPCSGAATPTPSLPPppANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    81 YMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   161 GPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGAEapGELGGLGPGPAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSH--VDNFLDGALVLEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   318 ILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAE--GAGEDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHevATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   396 IFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GDGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   633 RKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAgDEEEEEDG 712
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA-GDDDDDDE 719

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   713 SREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALG 792
Cdd:TIGR00845 720 DGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALG 799

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   793 TSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAV 872
Cdd:TIGR00845 800 TSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGV 879

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*....
gi 57163987   873 LLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
Cdd:TIGR00845 880 LLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-379 3.34e-74

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 239.52  E-value: 3.34e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 57163987   324 QKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRA 379
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
393-482 4.08e-39

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 139.69  E-value: 4.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIF 472
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|
gi 57163987   473 EEDEHFFVRL 482
Cdd:pfam03160  81 EGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 393-483 2.08e-35

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 129.30  E-value: 2.08e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGeGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIF 472
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 57163987    473 EEDEHFFVRLL 483
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 522-612 3.31e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 125.83  E-value: 3.31e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEEY 601
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-SDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 57163987    602 EKKDNFFIELG 612
Cdd:smart00237  80 EKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
522-612 1.17e-31

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 118.51  E-value: 1.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGA-RGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 57163987   601 YEKKDNFFIELG 612
Cdd:pfam03160  80 YEGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 747-912 7.37e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 95.75  E-value: 7.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   747 HGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNV 826
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   827 FLGLGVAWSVAAVYWAVQGRPFEvrtgtlaFSVTLFTVFAFVGIAVLLYRRRphiggelggPRGPKLATTALFLGLWLLY 906
Cdd:pfam01699  80 LLVLGLSALIGPVKVDSLLLKLD-------LGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVY 143


                  ....*.
gi 57163987   907 ILFASL 912
Cdd:pfam01699 144 LVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 74-245 1.04e-18

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 83.81  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    74 VYFVAMVYMFLGVSIIADRFMAAIEVItskekeititkangetsvGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGH 153
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVL------------------ARVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   154 NfqaGELGPGTIVGSAAFNMFVVIAVC--IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILavfsPGVVQVWEALL 231
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSalIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 57163987   232 TLVFFPVCVVFAWM 245
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 73-240 2.32e-12

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 71.18  E-value: 2.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987     73 VVYFVAMVYMFLGVSIIADR-FMAAIEVITSKekeititkangetsvgtVRIwNETVSNLTLMALGSSAPEILLSVIEV- 150
Cdd:TIGR00927  458 VLHIFGMMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVf 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    151 CGHNfqagELGPGTIVGSAAFNMFVVIAVCiyvipAGESRKIKHLrvffvtASWSIFAYVWLY-----LILAVFSPGVVQ 225
Cdd:TIGR00927  520 ISHS----NVGIGTIVGSAVFNILFVIGTC-----ALFSREILNL------TWWPLFRDVSFYildlmMLILFFLDSLIA 584

                          170
                   ....*....|....*
gi 57163987    226 VWEALLTLVFFPVCV 240
Cdd:TIGR00927  585 WWESLLLLLAYALYV 599
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
748-909 3.89e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 3.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 748 GWACFGVSILVIG--LLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 825
Cdd:COG0530 155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 826 VFLGLGvawsVAAVYwavqgrpfevRTGTLAFSVTLFTVFAFVGIAVLLY--RRRphiGGELGGPRGpklattALFLGLW 903
Cdd:COG0530 230 ILLVLG----IGALI----------TPIPVDPAVLSFDLPVMLAATLLLLglLRT---GGRIGRWEG------LLLLALY 286


                ....*.
gi 57163987 904 LLYILF 909
Cdd:COG0530 287 LAYLAL 292
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
761-910 2.52e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 59.38  E-value: 2.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 761 LLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGvawsVAAVY 840
Cdd:COG0530   3 LLVRGADALARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILG----LAALI 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 841 wavqgRPFEVRTGTLAFSVTLFTVFAFVGIAVLLyrrrphiGGELGGPRGpklattALFLGLWLLYILFA 910
Cdd:COG0530  74 -----RPLAVDRRVLRRDLPFLLLASLLLLALLL-------DGTLSRIDG------VILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
131-249 3.02e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 56.30  E-value: 3.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 131 LTLMALGSSAPEILLSVIEVCGHNFqagELGPGTIVGSAAFNMFVVIAVCIYVIPAgesrKIKHlRVFFVTASWSIFAYV 210
Cdd:COG0530  24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPL----AVDR-RVLRRDLPFLLLASL 95

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 57163987 211 wlyLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKR 249
Cdd:COG0530  96 ---LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 756-907 9.52e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.47  E-value: 9.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   756 ILVIGLLTALIG----------DLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 825
Cdd:TIGR00367   1 LLLIGYLILGLIlliygadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   826 VFLGLGVAWSVaavywavqgRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYrrrphiggelgGPRGPKLATTALFL-GLWL 904
Cdd:TIGR00367  80 ILLILGLSAIF---------SPIIVDKDWLRRDILFYLLVSILLLFFGLD-----------GQISRIDGVVLLILyIVYL 139


                  ...
gi 57163987   905 LYI 907
Cdd:TIGR00367 140 LFL 142
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 749-906 2.10e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 47.32  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   749 WACFGVSILVIGllTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCaDASIGNVTGSNAVNVFL 828
Cdd:TIGR00367 174 LLIIGLIGLVVG--SRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLG-DIAVGNVIGSNIFNILV 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57163987   829 GLGVAWSVAAVywavqgrPFEVRTGTLAFSVTLFTVFAFvgiaVLLYRRRPHIGGELGgprgpklattALFLGLWLLY 906
Cdd:TIGR00367 251 GLGVPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG----------ILLLALYIAY 307
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 77-244 4.04e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.55  E-value: 4.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987    77 VAMVYMFLGVSII-ADRFMAAIEVITSKEKEITItkangetsvgtvriwnetVSNLTLMALGSSAPEILLSVIEVCGHNf 155
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIARHLGISPL------------------IIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987   156 qaGELGPGTIVGSAAFNMFVVIAVCIYVIPagesrkikhlrvfFVTASWSIF----AYVWLYLILAVFspGVVQVWEALL 231
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdilFYLLVSILLLFF--GLDGQISRID 127

                         170
                  ....*....|...
gi 57163987   232 TLVFFPVCVVFAW 244
Cdd:TIGR00367 128 GVVLLILYIVYLL 140
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 752-855 5.36e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 46.18  E-value: 5.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987  752 FGVSILVIGLLTALIGD-----LASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNV 826
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81

                         90       100
                 ....*....|....*....|....*....
gi 57163987  827 FLGLGVAWSVaavywavqgRPFEVRTGTL 855
Cdd:PRK10734  82 LLILGLAALI---------RPFTVHSDVL 101
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 127-263 8.09e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.21  E-value: 8.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987  127 TVSNLTLMALGSSAPEILLSVIEVCGHNfqAGELGPGTIVGSAAFNMFVVI-AVCIYVipAGESRKIKHlRVFFVTASWS 205
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVVgIVSLCV--ADKEVQIDK-RCFIRDLCFF 252

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 57163987  206 IFAYVWLYLILAVfspGVVQVWEAlltLVFFPVCVVFAWMADKRLLFYKYVyKRYRTD 263
Cdd:PLN03151 253 LFTLVSLLVILMV---GKVTVGGA---IAFVSIYVVYAFLVAANEILRKHA-RRLKLD 303
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
124-242 2.57e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.89  E-value: 2.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57163987 124 WNETVSNLTLMALGSSAPEILLSVIEVcghnFQ-AGELGPGTIVGSAAFNMFVVIAVCIYVIPagesrkikhLRVFFVTA 202
Cdd:COG0530 184 VSELVIGLTIVAIGTSLPELATSIVAA----RKgEDDLAVGNIIGSNIFNILLVLGIGALITP---------IPVDPAVL 250

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 57163987 203 SWSIFAYV--WLYLILAVFSPGVVQVWEALLTLVFFPVCVVF 242
Cdd:COG0530 251 SFDLPVMLaaTLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH