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Conserved domains on  [gi|29826341|ref|NP_055914|]
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calmodulin-binding transcription activator 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 34-150 6.18e-70

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


:

Pssm-ID: 198144  Cd Length: 118  Bit Score: 229.21  E-value: 6.18e-70
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341      34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 29826341     113 ECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 150
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 534-614 6.03e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341    534 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 611
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81


                   ...
gi 29826341    612 FEY 614
Cdd:pfam01833   82 FTY 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
710-811 9.03e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341  710 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 788
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                         90       100
                 ....*....|....*....|...
gi 29826341  789 LGRLPLSVAHSRGHVRLARCLEE 811
Cdd:COG0666  218 DGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 34-150 6.18e-70

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 229.21  E-value: 6.18e-70
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341      34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 29826341     113 ECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 150
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 40-149 2.40e-54

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 184.78  E-value: 2.40e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341     40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGC 118
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIHCY 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 29826341    119 YVHSSIVPTFHRRCYWLLQNP-DIVLVHYLNV 149
Cdd:pfam03859   83 YAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 534-614 6.03e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341    534 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 611
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81


                   ...
gi 29826341    612 FEY 614
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
710-811 9.03e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341  710 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 788
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                         90       100
                 ....*....|....*....|...
gi 29826341  789 LGRLPLSVAHSRGHVRLARCLEE 811
Cdd:COG0666  218 DGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
715-807 1.51e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341    715 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 794
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65

                           90
                   ....*....|...
gi 29826341    795 SVAHSRGHVRLAR 807
Cdd:pfam12796   66 HYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 34-150 6.18e-70

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 229.21  E-value: 6.18e-70
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341      34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 29826341     113 ECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 150
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 40-149 2.40e-54

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 184.78  E-value: 2.40e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341     40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGC 118
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIHCY 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 29826341    119 YVHSSIVPTFHRRCYWLLQNP-DIVLVHYLNV 149
Cdd:pfam03859   83 YAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 534-614 6.03e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341    534 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 611
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81


                   ...
gi 29826341    612 FEY 614
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
710-811 9.03e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341  710 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 788
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                         90       100
                 ....*....|....*....|...
gi 29826341  789 LGRLPLSVAHSRGHVRLARCLEE 811
Cdd:COG0666  218 DGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
710-811 2.49e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341  710 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 788
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAdVNARDN 184

                         90       100
                 ....*....|....*....|...
gi 29826341  789 LGRLPLSVAHSRGHVRLARCLEE 811
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
711-809 1.56e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341  711 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDSL 789
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL--EAGAdVNAQDND 152

                         90       100
                 ....*....|....*....|
gi 29826341  790 GRLPLSVAHSRGHVRLARCL 809
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
715-807 1.51e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29826341    715 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 794
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65

                           90
                   ....*....|...
gi 29826341    795 SVAHSRGHVRLAR 807
Cdd:pfam12796   66 HYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
711-775 2.58e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 2.58e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29826341    711 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEvdPLNVDHFSCTPLMWACALGHLEAAVLL 775
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLL------------LEHA--DVNLKDNGRTALHYAARSGHLEIVKLL 80
Ank_5 pfam13857
Ankyrin repeats (many copies);
747-797 2.90e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 2.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 29826341    747 VDPLNVDHFSCTPLMWACALGHLEAAVLLFRwNRQALSIPDSLGRLPLSVA 797
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
711-775 7.12e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29826341    711 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLL 775
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLL------------LEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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