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Conserved domains on  [gi|170932522|ref|NP_057880|]
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interleukin-27 receptor subunit alpha isoform 1 precursor [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 1.25e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932522 123 PDTPQIFSQVDISEEatlEATVQWAPPVWPPQKVLICQFRYKECQAETWTRLEPQLKTDglTPVEMQNLEPGTCYQVsgR 202
Cdd:cd00063    1 PSPPTNLRVTDVTST---SVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSE--TSYTLTGLKPGTEYEF--R 73

                         90       100
                 ....*....|....*....|
gi 170932522 203 CQVENGYPWGEWSSPLSFQT 222
Cdd:cd00063   74 VRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 1.25e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932522 123 PDTPQIFSQVDISEEatlEATVQWAPPVWPPQKVLICQFRYKECQAETWTRLEPQLKTDglTPVEMQNLEPGTCYQVsgR 202
Cdd:cd00063    1 PSPPTNLRVTDVTST---SVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSE--TSYTLTGLKPGTEYEF--R 73

                         90       100
                 ....*....|....*....|
gi 170932522 203 CQVENGYPWGEWSSPLSFQT 222
Cdd:cd00063   74 VRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 1.25e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932522 123 PDTPQIFSQVDISEEatlEATVQWAPPVWPPQKVLICQFRYKECQAETWTRLEPQLKTDglTPVEMQNLEPGTCYQVsgR 202
Cdd:cd00063    1 PSPPTNLRVTDVTST---SVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSE--TSYTLTGLKPGTEYEF--R 73

                         90       100
                 ....*....|....*....|
gi 170932522 203 CQVENGYPWGEWSSPLSFQT 222
Cdd:cd00063   74 VRAVNGGGESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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