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Conserved domains on  [gi|8923530|ref|NP_060351|]
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nicotinamide riboside kinase 1 isoform 1 [Homo sapiens]

Protein Classification

nicotinamide riboside kinase( domain architecture ID 10113996)

nicotinamide riboside kinase catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-160 2.07e-91

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


:

Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 265.34  E-value: 2.07e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVV 82
Cdd:cd02024   1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530   83 ST---------------------DQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQP----- 136
Cdd:cd02024  81 SHgnendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                       170       180
                ....*....|....*....|....*
gi 8923530  137 -PDSPGYFDGHVWPMYLKYRQEMQD 160
Cdd:cd02024 161 wPDPPGYFDGHVWPMYLKHHAEMFE 185
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-160 2.07e-91

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 265.34  E-value: 2.07e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVV 82
Cdd:cd02024   1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530   83 ST---------------------DQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQP----- 136
Cdd:cd02024  81 SHgnendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                       170       180
                ....*....|....*....|....*
gi 8923530  137 -PDSPGYFDGHVWPMYLKYRQEMQD 160
Cdd:cd02024 161 wPDPPGYFDGHVWPMYLKHHAEMFE 185
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-154 1.14e-25

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 98.37  E-value: 1.14e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    1 MKTFIIGISGVTNSGKTTLAKNLQKHLP--NCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWmeSAR 78
Cdd:COG0572   5 GKPRIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPL--KAG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530   79 HSVV------STDQESAEEI-----PILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRR-----STRVYQPPDSPGY 142
Cdd:COG0572  83 ESVElpvydfATGTRSGETVkvepaDVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIEQ 162

                       170
                ....*....|..
gi 8923530  143 FDGHVWPMYLKY 154
Cdd:COG0572 163 YWATVRPGHEQY 174
AAA_18 pfam13238
AAA domain;
6-148 4.67e-17

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 73.62  E-value: 4.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530      6 IGISGVTNSGKTTLAKNLQKHLpNCSVISQDDFFKPESEIETDKNgflqYDVLEALNMEKMMSAISCWMESArhsvvstd 85
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENA-------- 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923530     86 qeSAEEIPILIIEGFLLFNYKPLDTIWNRsYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVW 148
Cdd:pfam13238  68 --ALEEGGNLIIDGHLAELEPERAKDLVG-IVLRASPEELLERLEKRGYEEAKIKENEEAEIL 127
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-132 4.58e-08

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 50.93  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     1 MKTFIIGISGVTNSGKTTLAKNLQKHLPN--CSVISQDDFFKPESEIETDKNGFLQYD---------VLEALNMEKMMSA 69
Cdd:PRK05480   4 KKPIIIGIAGGSGSGKTTVASTIYEELGDesIAVIPQDSYYKDQSHLSFEERVKTNYDhpdafdhdlLIEHLKALKAGKA 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923530    70 ISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTR 132
Cdd:PRK05480  84 IEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKR 146
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 5-160 2.07e-91

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 265.34  E-value: 2.07e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESA--RHSVV 82
Cdd:cd02024   1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhfPKFLR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530   83 ST---------------------DQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQP----- 136
Cdd:cd02024  81 SHgnendpekefiedaqieetkaDLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTGYVtlegf 160

                       170       180
                ....*....|....*....|....*
gi 8923530  137 -PDSPGYFDGHVWPMYLKYRQEMQD 160
Cdd:cd02024 161 wPDPPGYFDGHVWPMYLKHHAEMFE 185
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-154 1.14e-25

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 98.37  E-value: 1.14e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    1 MKTFIIGISGVTNSGKTTLAKNLQKHLP--NCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWmeSAR 78
Cdd:COG0572   5 GKPRIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPL--KAG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530   79 HSVV------STDQESAEEI-----PILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRR-----STRVYQPPDSPGY 142
Cdd:COG0572  83 ESVElpvydfATGTRSGETVkvepaDVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRivrdgEERGRTAESVIEQ 162

                       170
                ....*....|..
gi 8923530  143 FDGHVWPMYLKY 154
Cdd:COG0572 163 YWATVRPGHEQY 174
AAA_18 pfam13238
AAA domain;
6-148 4.67e-17

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 73.62  E-value: 4.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530      6 IGISGVTNSGKTTLAKNLQKHLpNCSVISQDDFFKPESEIETDKNgflqYDVLEALNMEKMMSAISCWMESArhsvvstd 85
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRL-GFGDNVRDLALENGLVLGDDPE----TRESKRLDEDKLDRLLDLLEENA-------- 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923530     86 qeSAEEIPILIIEGFLLFNYKPLDTIWNRsYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVW 148
Cdd:pfam13238  68 --ALEEGGNLIIDGHLAELEPERAKDLVG-IVLRASPEELLERLEKRGYEEAKIKENEEAEIL 127
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 5-132 5.05e-10

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 56.41  E-value: 5.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHLPN--CSVISQDDFFKPES--EIETDKNGF----------LQYDVLEALnmeKMMSAI 70
Cdd:cd02023   1 IIGIAGGSGSGKTTVAEEIIEQLGNpkVVIISQDSYYKDLSheELEERKNNNydhpdafdfdLLISHLQDL---KNGKSV 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8923530   71 SCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTR 132
Cdd:cd02023  78 EIPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIER 139
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-132 4.58e-08

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 50.93  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     1 MKTFIIGISGVTNSGKTTLAKNLQKHLPN--CSVISQDDFFKPESEIETDKNGFLQYD---------VLEALNMEKMMSA 69
Cdd:PRK05480   4 KKPIIIGIAGGSGSGKTTVASTIYEELGDesIAVIPQDSYYKDQSHLSFEERVKTNYDhpdafdhdlLIEHLKALKAGKA 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923530    70 ISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTR 132
Cdd:PRK05480  84 IEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKR 146
PRK06696 PRK06696
uridine kinase; Validated
 6-128 1.04e-07

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 50.36  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     6 IGISGVTNSGKTTLAKNLQKHL--PNCSVI--SQDDFFKPEsEI-----ETDKNGFLQ----YDVLEALNMEKMMSAISC 72
Cdd:PRK06696  25 VAIDGITASGKTTFADELAEEIkkRGRPVIraSIDDFHNPR-VIryrrgRESAEGYYEdaydYTALRRLLLDPLGPNGDR 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8923530    73 WMESARHSVVsTDQE------SAEEIPILIIEGFLLFNyKPLDTIWNRSYFLTIPYEECKRR 128
Cdd:PRK06696 104 QYRTASHDLK-TDIPvhnpplLAAPNAVLIVDGTFLLR-PELRDLWDYKIFLDTDFEVSRRR 163
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 5-62 2.05e-07

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 48.84  E-value: 2.05e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHL----PNCSVISQDDFFKPEsEIETDKNGFlqYDV-----LEALN 62
Cdd:cd02028   1 VVGIAGPSGSGKTTFAKKLSNQLrvngIGPVVISLDDYYVPR-KTPRDEDGN--YDFesildLDLLN 64
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 5-68 4.58e-06

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 45.38  E-value: 4.58e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHL------PNCSVISQDDFFKPESEIET----DKNGFlqydvLEALNMEKMMS 68
Cdd:cd02025   1 IIGIAGSVAVGKSTTARVLQALLsrwpdhPNVELITTDGFLYPNKELIErglmDRKGF-----PESYDMEALLK 69
PRK08233 PRK08233
hypothetical protein; Provisional
 1-44 6.76e-06

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 44.73  E-value: 6.76e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 8923530     1 MKTFIIGISGVTNSGKTTLAKNLQKHLPNcSVISQDDFFKPESE 44
Cdd:PRK08233   1 KKTKIITIAAVSGGGKTTLTERLTHKLKN-SKALYFDRYDFDNC 43
PRK06762 PRK06762
hypothetical protein; Provisional
 1-36 1.79e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 40.34  E-value: 1.79e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 8923530     1 MKTFIIgISGVTNSGKTTLAKNLQKHL-PNCSVISQD 36
Cdd:PRK06762   1 MTTLII-IRGNSGSGKTTIAKQLQERLgRGTLLVSQD 36
PTZ00301 PTZ00301
uridine kinase; Provisional
 1-132 4.35e-04

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 39.60  E-value: 4.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     1 MKTFIIGISGVTNSGKTTLAKN-LQKHLPNC-----SVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWM 74
Cdd:PTZ00301   1 MPCTVIGISGASGSGKSSLSTNiVSELMAHCgpvsiGVICEDFYYRDQSNIPESERAYTNYDHPKSLEHDLLTTHLRELK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8923530    75 ESAR---------HSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTR 132
Cdd:PTZ00301  81 SGKTvqipqydyvHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDICLIRRAKR 147
COG4639 COG4639
Predicted kinase [General function prediction only];
6-38 6.51e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 38.27  E-value: 6.51e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 8923530    6 IGISGvtnSGKTTLAKnlqKHLPNCSVISQDDF 38
Cdd:COG4639   8 IGLPG---SGKSTFAR---RLFAPTEVVSSDDI 34
PRK04182 PRK04182
cytidylate kinase; Provisional
 5-39 9.67e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 38.25  E-value: 9.67e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 8923530     5 IIGISGVTNSGKTTLAKNLQKHLpNCSVISQDDFF 39
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKL-GLKHVSAGEIF 35
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-148 5.18e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 35.75  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530      3 TFIIGISGvtnSGKTTLAKNLQKHLPnCSVISQDDFFK------PESEIETDKNGFLQYDVLEALNMEKMMSAISC---- 72
Cdd:pfam13671   2 ILLVGLPG---SGKSTLARRLLEELG-AVRLSSDDERKrlfgegRPSISYYTDATDRTYERLHELARIALRAGRPVilda 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     73 --WMESARHSVVstdqESAEEI--PILIIegfllfnykpldtiwnrsYFLTiPYEECKRRRSTRVYQpPDSPGYFDGHVW 148
Cdd:pfam13671  78 tnLRRDERARLL----ALAREYgvPVRIV------------------VFEA-PEEVLRERLAARARA-GGDPSDVPEEVL 133
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 5-27 7.87e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 33.85  E-value: 7.87e-03
                        10        20
                ....*....|....*....|...
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHL 27
Cdd:cd02019   1 IIAITGGSGSGKSTVAKKLAEQL 23
PRK07667 PRK07667
uridine kinase; Provisional
 4-57 8.38e-03

uridine kinase; Provisional


Pssm-ID: 169051  Cd Length: 193  Bit Score: 35.86  E-value: 8.38e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923530     4 FIIGISGVTNSGKTTLAKNL-----QKHLPNCsVISQDDFFkpeseIETDK---NGF--------LQYDV 57
Cdd:PRK07667  18 FILGIDGLSRSGKTTFVANLkenmkQEGIPFH-IFHIDDYI-----VERNKryhTGFeewyeyyyLQWDI 81
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 5-70 8.68e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 35.31  E-value: 8.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8923530    5 IIGISGVTNSGKTTLAKNLQKHLpNCSVISQDDFFKPEseietdkngflqydvlealNMEKMMSAI 70
Cdd:cd02021   1 IIVVMGVSGSGKSTVGKALAERL-GAPFIDGDDLHPPA-------------------NIAKMAAGI 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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