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Conserved domains on  [gi|59850762|ref|NP_060473|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-269 3.73e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   32 NKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKY 111
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  112 GHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGA 191
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  192 DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKG 269
Cdd:COG0666  211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 545-1346 3.32e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 94.35  E-value: 3.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    545 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 623
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    624 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 703
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 783
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    784 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 861
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    862 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 918
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    919 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 975
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    976 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1135
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1136 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1204
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1205 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762   1284 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1346
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PLN02939 super family cl33600
transferase, transferring glycosyl groups
 251-603 1.23e-03

transferase, transferring glycosyl groups


The actual alignment was detected with superfamily member PLN02939:

Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   251 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 327
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   328 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 387
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   388 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 455
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   456 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 535
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762   536 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-269 3.73e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   32 NKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKY 111
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  112 GHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGA 191
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  192 DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKG 269
Cdd:COG0666  211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-231 1.61e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    48 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 123
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   124 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 201
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 59850762   202 TALMLGCEYGCRDAVEVLIKNGADISLLDA 231
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 545-1346 3.32e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 94.35  E-value: 3.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    545 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 623
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    624 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 703
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 783
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    784 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 861
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    862 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 918
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    919 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 975
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    976 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1135
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1136 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1204
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1205 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762   1284 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1346
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-197 2.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    105 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 184
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 59850762    185 LLIDRGADVNSRD 197
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 466-1273 3.78e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 78.26  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKehltseaASGNHRLTEELKDQ 545
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKK-------AEAVKKAEEAKKDA 1239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   546 LKDLKVKYEGASAEVGKLRN-QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 624
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEaRMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   625 LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK 704
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   705 ITELTLKNQTLQKEIEKvyldnKLLKEQAHNLTIEMKnhyvplKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE--KKLEM 782
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAA-----KKKADEAKKKAEEKK------KADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEE 1468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNiVELKKQLSELKKkcGEDQEKIHALTSENTNLKKMMSNQYVPV 862
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-AEAKKKADEAKK--AEEAKKADEAKKAEEAKKADEAKKAEEK 1545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV 942
Cdd:PTZ00121 1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   943 QDSNAEilanyRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKfkaTEKELKDQLSEQTQKysvsEEE 1022
Cdd:PTZ00121 1626 KKAEEE-----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKA----AEA 1693

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1023 VKKNKQEndklKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKnvkeklVEENAKQTSEILA 1102
Cdd:PTZ00121 1694 LKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK------KDEEEKKKIAHLK 1763

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1103 VQNLLQKQHVPLEQVEALKKSLNgtienlKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Cdd:PTZ00121 1764 KEEEKKAEEIRKEKEAVIEEELD------EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVAD 1837

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1183 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK--------LETREVVDLSKyKATKSDLETQISSLNEKLAN----- 1249
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKekdlkeddEEEIEEADEIE-KIDKDDIEREIPNNNMAGKNndiid 1916

                         810       820       830
                  ....*....|....*....|....*....|..
gi 59850762  1250 --------LNRKYEEVCEEVLHAKKKEISAKD 1273
Cdd:PTZ00121 1917 dkldkdeyIKRDAEETREEIIKISKKDMCIND 1948
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 442-1211 1.22e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 66.30  E-value: 1.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    442 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 521
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    522 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 596
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    597 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 676
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    677 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 751
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    752 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 830
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    831 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    905 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 983
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    984 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1052
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1053 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1128
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1199
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 59850762   1200 EVSKLQSEVQNT 1211
Cdd:pfam15921  831 EQESVRLKLQHT 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1041-1414 1.57e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1041 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1120
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1121 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
Cdd:COG1196  301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1201 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1280
Cdd:COG1196  374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1281 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1360
Cdd:COG1196  441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 59850762 1361 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1414
Cdd:COG1196  513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 105-233 2.78e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  105 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 169
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  170 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 233
Cdd:cd22192   92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 748-1121 6.02e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 6.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   748 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 827
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   828 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 903
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   904 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 983
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   984 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1045
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1046 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1119
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 59850762  1120 LK 1121
Cdd:NF033838  445 EK 446
PLN02939 PLN02939
transferase, transferring glycosyl groups
 251-603 1.23e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   251 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 327
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   328 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 387
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   388 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 455
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   456 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 535
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762   536 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 30-265 3.94e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 3.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762     30 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 103
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    104 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 179
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    180 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 244
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 59850762    245 nlDILTLLKTASENTNKGREL 265
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 437-734 4.19e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   437 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 514
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   515 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 594
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   595 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 655
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   656 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 726
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 59850762   727 KLLKEQAH 734
Cdd:NF033838  396 KKAEEEAK 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 290-721 7.77e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 7.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  290 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 369
Cdd:COG1196  396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  370 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 449
Cdd:COG1196  476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  450 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 524
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  525 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 604
Cdd:COG1196  629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  605 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 678
Cdd:COG1196  709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 59850762  679 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 721
Cdd:COG1196  787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-269 3.73e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 3.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   32 NKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKY 111
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  112 GHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGA 191
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  192 DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKG 269
Cdd:COG0666  211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-261 4.04e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 4.04e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   30 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAA 109
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  110 KYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDR 189
Cdd:COG0666   96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762  190 GADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNK 261
Cdd:COG0666  176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-252 2.51e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 119.29  E-value: 2.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   53 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADL 132
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  133 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 212
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 59850762  213 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 252
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-204 2.71e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.09  E-value: 2.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   38 LMKAAERGDVEKVTsILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCL 117
Cdd:COG0666  124 LHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  118 QKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 197
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                 ....*..
gi 59850762  198 KQNRTAL 204
Cdd:COG0666  283 LDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 48-231 1.61e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    48 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 123
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   124 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 201
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 59850762   202 TALMLGCEYGCRDAVEVLIKNGADISLLDA 231
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 545-1346 3.32e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 94.35  E-value: 3.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    545 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 623
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    624 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 703
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 783
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    784 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 861
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    862 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 918
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    919 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 975
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    976 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1135
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1136 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1204
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1205 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762   1284 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1346
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
84-252 7.44e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 7.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   84 LNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 163
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  164 DVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIG 243
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                 ....*....
gi 59850762  244 DNLDILTLL 252
Cdd:COG0666  164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-197 2.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    105 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 184
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 59850762    185 LLIDRGADVNSRD 197
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 2.20e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.62  E-value: 2.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762     72 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEhaDLQGRTALHDAAMADCPSSIQ 151
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 59850762    152 LLCDHGASVNAKD 164
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-230 1.39e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    138 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 217
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 59850762    218 VLIKNGADISLLD 230
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 772-1414 3.38e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.26  E-value: 3.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    772 TQKYTEKKLEMEKLLLENDSLSKD--VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 849
Cdd:TIGR02168  212 AERYKELKAELRELELALLVLRLEelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    850 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 929
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    930 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS--FEECERKFKATEKELKD 1007
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1008 QLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1087
Cdd:TIGR02168  452 LQEELERL----EEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1088 KL-VEENAKQTSEIL---AVQNLL-QKQHVPLEQVEALKKSLNG-------------TIENLKEELKSMQRCYEKEQ--- 1146
Cdd:TIGR02168  528 LIsVDEGYEAAIEAAlggRLQAVVvENLNAAKKAIAFLKQNELGrvtflpldsikgtEIQGNDREILKNIEGFLGVAkdl 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1147 -QTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEKEVGII--------------------KASLREKEEESQNKMEEVS 1202
Cdd:TIGR02168  608 vKFDPKLRKALSYLLGGVLVvddLDNALELAKKLRPGYRIVtldgdlvrpggvitggsaktNSSILERRREIEELEEKIE 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1203 KLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH 1279
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEeleEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1280 FSI-----------------EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLt 1342
Cdd:TIGR02168  768 ERLeeaeeelaeaeaeieelEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ- 846

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59850762   1343 ytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT-----HLLSAAQGHMDEDVQEALLQIIQMRQGL 1414
Cdd:TIGR02168  847 ------IEELSEDIESLAAEIEELEELIEELESELEALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 689-1327 6.71e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.06  E-value: 6.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    689 QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 768
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    769 LDVTQKYTEKKLEMEKllleNDSLSKDVSRLEtvfvppekheKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN 848
Cdd:TIGR04523  197 LKLELLLSNLKKKIQK----NKSLESQISELK----------KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    849 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEH 928
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---------KEQDWNKELKSELKNQEKKLEEIQNQISQN 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    929 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 1008
Cdd:TIGR04523  334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1009 LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Cdd:TIGR04523  414 IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN-------LDNTRESLETQLKVLSRSINKIKQNLEQ 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1089 LVEENAKQTSEILAVQNLlqkqhvpleqvealKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKnssvplae 1168
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEE--------------KKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE-------- 544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1169 hlqiKEAFEKEVGIIKASLrekEEESQNKMEEVSKLQSEVQNTKQALKKLETrevvDLSKYKATKSDLETQISSLNEKLA 1248
Cdd:TIGR04523  545 ----DELNKDDFELKKENL---EKEIDEKNKEIEELKQTQKSLKKKQEEKQE----LIDQKEKEKKDLIKEIEEKEKKIS 613

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762   1249 NLNRKYEEVCEEvlhaKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIeakdNKITELLND 1327
Cdd:TIGR04523  614 SLEKELEKAKKE----NEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI----DDIIELMKD 684
PTZ00121 PTZ00121
MAEBL; Provisional
 466-1273 3.78e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 78.26  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKehltseaASGNHRLTEELKDQ 545
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKK-------AEAVKKAEEAKKDA 1239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   546 LKDLKVKYEGASAEVGKLRN-QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 624
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEaRMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   625 LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK 704
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   705 ITELTLKNQTLQKEIEKvyldnKLLKEQAHNLTIEMKnhyvplKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE--KKLEM 782
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAA-----KKKADEAKKKAEEKK------KADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEE 1468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNiVELKKQLSELKKkcGEDQEKIHALTSENTNLKKMMSNQYVPV 862
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-AEAKKKADEAKK--AEEAKKADEAKKAEEAKKADEAKKAEEK 1545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV 942
Cdd:PTZ00121 1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   943 QDSNAEilanyRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKfkaTEKELKDQLSEQTQKysvsEEE 1022
Cdd:PTZ00121 1626 KKAEEE-----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKA----AEA 1693

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1023 VKKNKQEndklKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKnvkeklVEENAKQTSEILA 1102
Cdd:PTZ00121 1694 LKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK------KDEEEKKKIAHLK 1763

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1103 VQNLLQKQHVPLEQVEALKKSLNgtienlKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Cdd:PTZ00121 1764 KEEEKKAEEIRKEKEAVIEEELD------EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVAD 1837

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1183 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK--------LETREVVDLSKyKATKSDLETQISSLNEKLAN----- 1249
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKekdlkeddEEEIEEADEIE-KIDKDDIEREIPNNNMAGKNndiid 1916

                         810       820       830
                  ....*....|....*....|....*....|..
gi 59850762  1250 --------LNRKYEEVCEEVLHAKKKEISAKD 1273
Cdd:PTZ00121 1917 dkldkdeyIKRDAEETREEIIKISKKDMCIND 1948
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
630-1219 5.86e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 77.03  E-value: 5.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   630 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 709
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   710 LKNQTLQKEIEKVYLDNKLLKEQAHNLtiemknhyvplkvsEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 789
Cdd:PRK03918  259 EKIRELEERIEELKKEIEELEEKVKEL--------------KELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   790 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 869
Cdd:PRK03918  317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   870 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 949
Cdd:PRK03918  385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   950 LANYRKgqeEIvtlhAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFkATEKELKDQLSEQTQKYS-VSEEEVKKNKQ 1028
Cdd:PRK03918  454 LEEYTA---EL----KRIEKELKEIEEKERKLRKELRELEKVLKKESEL-IKLKELAEQLKELEEKLKkYNLEELEKKAE 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1029 ENDKLKKEIFTLQKDLRDktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ 1108
Cdd:PRK03918  526 EYEKLKEKLIKLKGEIKS----LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFY 601

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1109 KQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEnQKNSSVPLAEHLQIKEAF---EKEVGIIKA 1185
Cdd:PRK03918  602 NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE-ELEKKYSEEEYEELREEYlelSRELAGLRA 680

                         570       580       590
                  ....*....|....*....|....*....|....
gi 59850762  1186 SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1219
Cdd:PRK03918  681 ELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-226 1.10e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.06  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    75 VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLC 154
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762   155 dHGASVNAKDVDGRTpLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 226
Cdd:PLN03192  612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
540-1140 3.13e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.72  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF---KRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 616
Cdd:PRK03918  203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIeelEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   617 KELsaklalsipaekfenmksslsNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaqhvkpEEHEQVKSRLEQ 696
Cdd:PRK03918  283 KEL---------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEI------NGIEERIKELEE 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   697 KSGELGkkitELTLKNQTLQKEIEKVYLDNKLLkEQAHNLTIEMKNHyvplkvsedMKKSHDAIIDDLNRKLLDVTQKYT 776
Cdd:PRK03918  336 KEERLE----ELKKKLKELEKRLEELEERHELY-EEAKAKKEELERL---------KKRLTGLTPEKLEKELEELEKAKE 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   777 EKKLEMEKLllendslskdvsrletvfvppekhEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTnlKKMMS 856
Cdd:PRK03918  402 EIEEEISKI------------------------TARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHR--KELLE 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   857 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDiNQEFVKIKDKNEILKrNLENTQNQIKAEYISLAEHEakmssls 936
Cdd:PRK03918  456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLK-ELEEKLKKYNLEELEKKAEE------- 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   937 qsmrkvqdsnaeilanYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKY 1016
Cdd:PRK03918  527 ----------------YEKLKEKLIKLKGEIKSLKKELEKLEELKKKL-------AELEKKLDELEEELAELLKELEELG 583

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL-VEENAK 1095
Cdd:PRK03918  584 FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEE 663

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 59850762  1096 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1140
Cdd:PRK03918  664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 305-1137 3.14e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 3.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    305 DLKERLRKIQQeqRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSG 384
Cdd:TIGR02168  217 ELKAELRELEL--ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    385 SHFSNRKEDMLLKQGQMYMADSQctspgipahmqsrsmlrPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQ 464
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANLERQ-----------------LEELEAQLEELESKLDELAEELAELEEKLEELKEELESLE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    465 NELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELKD 544
Cdd:TIGR02168  358 AELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIEE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    545 QLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 624
Cdd:TIGR02168  426 LLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    625 LsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSGE 700
Cdd:TIGR02168  493 S---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQNE 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    701 LGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLN-----RKLLD--- 770
Cdd:TIGR02168  570 LGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDLDnalelAKKLRpgy 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    771 --VT--------------------QKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLS 828
Cdd:TIGR02168  646 riVTldgdlvrpggvitggsaktnSSILERRREIEELEEKIEELEEKIAELEKAL---AELRKELEELEEELEQLRKELE 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    829 ELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 908
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    909 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY--- 985
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLner 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    986 ----APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK-TVLIEKSHEMERA 1060
Cdd:TIGR02168  883 asleEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENK 962

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59850762   1061 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEilavQNLLQKQHvplEQVEALKKSLNGTIENLKEELKS 1137
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKER----YDFLTAQK---EDLTEAKETLEEAIEEIDREARE 1032
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-245 3.49e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 3.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    45 GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAGRNALH--LAAKYGHALCLQKLL 121
Cdd:PHA03095   60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIkAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   122 QYNCPTEHADLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDVDGRTPL--VLATQMSRPTICQLLIDRGADV 193
Cdd:PHA03095  140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRAGCDP 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 59850762   194 NSRDKQNRTALMLGCEYG-CRDA-VEVLIKNGADISLLDALGHDSSYYARIGDN 245
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
886-1324 5.53e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.94  E-value: 5.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   886 VKKKFEDINQEFVKIKDKNEILKRNLENtqnqIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHA 965
Cdd:PRK03918  198 KEKELEEVLREINEISSELPELREELEK----LEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   966 EIKAQKKELDTIQEcIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKkEIFTLQKDLR 1045
Cdd:PRK03918  274 EIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1046 DKTVLIEKSHE--------MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1117
Cdd:PRK03918  352 KRLEELEERHElyeeakakKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1118 EA-------------------LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK 1178
Cdd:PRK03918  432 KKakgkcpvcgrelteehrkeLLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEK 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1179 EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevvdlsKYKATKSDLETQISSLNEKLANLNRKYEEV- 1257
Cdd:PRK03918  512 LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE--------ELKKKLAELEKKLDELEEELAELLKELEELg 583

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762  1258 --CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL 1324
Cdd:PRK03918  584 feSVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEEL 652
PTZ00121 PTZ00121
MAEBL; Provisional
 632-1330 6.21e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.02  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   632 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 711
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKA 1160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   712 NQTLQKEIEKVYLDNKllKEQAHNLTIEMKNHYvPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS 791
Cdd:PTZ00121 1161 EDARKAEEARKAEDAK--KAEAARKAEEVRKAE-ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   792 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkkmmsnqyvpvKTHEEVKMT 871
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK------------KAEEKKKAD 1305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   872 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILA 951
Cdd:PTZ00121 1306 EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA-----AADEAEAAEEKAEAAEKKKEEAKKKA 1380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   952 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQE 1029
Cdd:PTZ00121 1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAEEAKKAE 1460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1030 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQlKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1106
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKaeeAKKKADEAKKA-AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1107 LQKQHV----PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Cdd:PTZ00121 1540 KKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1183 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL 1262
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE 1699

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1263 HAKKKEISAKDEKELLHfSIEQEIKDQKERCDKS--LTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAeeAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
PTZ00121 PTZ00121
MAEBL; Provisional
 520-1317 1.03e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.64  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   520 FLALKEHLTSEAASGNHRLTEELKdQLKDLKVKYEGASAEVGKLRNQIKQNEmivEEFKRDEGKLIEENKRLQKELSMCE 599
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAK-KTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRVEI 1156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   600 MEREKKGRKVTEMEGQAKELSAKlalsiPAEKFENMKSSLSNEVNEKAKKLVEMER-EHEKSLSEIRQLKRELENVKAKL 678
Cdd:PTZ00121 1157 ARKAEDARKAEEARKAEDAKKAE-----AARKAEEVRKAEELRKAEDARKAEAARKaEEERKAEEARKAEDAKKAEAVKK 1231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   679 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI--EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 756
Cdd:PTZ00121 1232 AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKA 1311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   757 HDAiiddlnRKLLDVTQKYTEKKLEMEKLLLENDSLSKdvsRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGE 836
Cdd:PTZ00121 1312 EEA------KKADEAKKKAEEAKKKADAAKKKAEEAKK---AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA 1382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   837 DQEKIHALTSENTNLKKMMSNQyvpvKTHEEVKMTlndtlAKTNRELLDVKKKFEDinqefvkiKDKNEILKRNLENTQn 916
Cdd:PTZ00121 1383 AKKKAEEKKKADEAKKKAEEDK----KKADELKKA-----AAAKKKADEAKKKAEE--------KKKADEAKKKAEEAK- 1444

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   917 qiKAEYISLAEHEAKMSSlsqsmrkvqdsNAEILANYRKGQEEIVTlHAEIKAQKKELDTIQECIKVKYApivsfeecER 996
Cdd:PTZ00121 1445 --KADEAKKKAEEAKKAE-----------EAKKKAEEAKKADEAKK-KAEEAKKADEAKKKAEEAKKKAD--------EA 1502

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKdlS 1076
Cdd:PTZ00121 1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA--L 1580

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1077 QKYTEVKNVKEKLVEENAKQTSEILAVQ-NLLQKQHVPLEQVEALKKSlngtienlKEELKSMQRCYEKEQQTVTKLHQL 1155
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELKKA--------EEEKKKVEQLKKKEAEEKKKAEEL 1652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1156 LENQKNSSVPlAEHLQIKEAFEKEvgiiKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1235
Cdd:PTZ00121 1653 KKAEEENKIK-AAEEAKKAEEDKK----KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1236 LETQISSLNEKLANLNRKYEEvceevlhAKKKEisaKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIE 1315
Cdd:PTZ00121 1728 NKIKAEEAKKEAEEDKKKAEE-------AKKDE---EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797


                  ..
gi 59850762  1316 AK 1317
Cdd:PTZ00121 1798 KK 1799
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 540-1257 1.21e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.18  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF-KRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKE 618
Cdd:TIGR02169  240 EAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELnKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELED 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    619 LSAKLA-LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQK 697
Cdd:TIGR02169  320 AEERLAkLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR--DELKDYREKLEKL 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    698 SGELGKKITELTLKNQTLQK-EIEKVYLDNKL--LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK 774
Cdd:TIGR02169  398 KREINELKRELDRLQEELQRlSEELADLNAAIagIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEE 477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    775 YTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC-------------------- 834
Cdd:TIGR02169  478 YDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYataievaagnrlnnvvvedd 557

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    835 GEDQEKIHALTSENTN------LKKMMSNQYVPVKTHEE-------------------VKMTLNDTLA----KTNRELLD 885
Cdd:TIGR02169  558 AVAKEAIELLKRRKAGratflpLNKMRDERRDLSILSEDgvigfavdlvefdpkyepaFKYVFGDTLVvediEAARRLMG 637

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    886 ----------------------VKKKFEDINQefVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQ 943
Cdd:TIGR02169  638 kyrmvtlegelfeksgamtggsRAPRGGILFS--RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    944 DSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYsvSEEEV 1023
Cdd:TIGR02169  716 RKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRI 793

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLsqkyTEVKNVKEKLVEENAKQTSEILAV 1103
Cdd:TIGR02169  794 PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEE 869

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1104 qnlLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGII 1183
Cdd:TIGR02169  870 ---LEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK----------LEALEEELSEI 936

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1184 KASLREKEEESQNKMEEvSKLQSEVQNTKQALKKLET----------REVVDLSKYKATKSDLETQISSLNEKLANLNRK 1253
Cdd:TIGR02169  937 EDPKGEDEEIPEEELSL-EDVQAELQRVEEEIRALEPvnmlaiqeyeEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015


                   ....
gi 59850762   1254 YEEV 1257
Cdd:TIGR02169 1016 KREV 1019
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 48-235 2.30e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    48 EKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 127
Cdd:PHA02874  105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   128 EHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIcQLLIDrGADVNSRDKQNRTALMLG 207
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                         170       180
                  ....*....|....*....|....*....
gi 59850762   208 CEYGC-RDAVEVLIKNGADISLLDALGHD 235
Cdd:PHA02874  262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 308-1140 2.65e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.01  E-value: 2.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    308 ERLRKIQQEQRilldkvnglQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALknrfkyfESDHLGSGSHF 387
Cdd:TIGR02168  213 ERYKELKAELR---------ELELALLVLRLEELREELEELQEELKEAEEELEELTAELQEL-------EEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    388 SNRKEDMLLKQGQMYMADSQCT--SPGIPAHMQSRSMLR--PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKL 463
Cdd:TIGR02168  277 SELEEEIEELQKELYALANEISrlEQQKQILRERLANLErqLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    464 QNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELK 543
Cdd:TIGR02168  357 EAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    544 DQLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL 623
Cdd:TIGR02168  425 ELLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    624 ALsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSG 699
Cdd:TIGR02168  492 DS---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQN 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    700 ELGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLnrklldvtqkytE 777
Cdd:TIGR02168  569 ELGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDL------------D 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    778 KKLEMEKLLLENDSL-SKDVSRLETVFVPPEKHEKEiialKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 856
Cdd:TIGR02168  633 NALELAKKLRPGYRIvTLDGDLVRPGGVITGGSAKT----NSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    857 NQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA-------EYISLAEHE 929
Cdd:TIGR02168  709 EL-------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEleerleeAEEELAEAE 781

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    930 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK----NV 1085
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvridNL 941

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 59850762   1086 KEKLVEEnakqtseilavqnllqkQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1140
Cdd:TIGR02168  942 QERLSEE-----------------YSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 551-1329 3.34e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    551 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG----RKVTEMEGQAKELSAKLA-L 625
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGyellKEKEALERQKEAIERQLAsL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    626 SIPAEKFENMKSSLSNEVNEKAKKLVEMERE-HEKSLSEIRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGK 703
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLErSIAEKERELEDAEERLAKLEA 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK-VSEDMKKSHDAIiDDLNRKLLDVTQKYTEKKLEM 782
Cdd:TIGR02169  330 EIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEeVDKEFAETRDEL-KDYREKLEKLKREINELKREL 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    783 EKLLLENDSLSKDVSRletvfvppekHEKEIIALKSNIVELKKQLSELkkkcgedQEKIHALTSENTNLKKMMSNQYVPV 862
Cdd:TIGR02169  409 DRLQEELQRLSEELAD----------LNAAIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAADLSKYEQEL 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIkAEYISLAEHEAKMSSLSQSMR-- 940
Cdd:TIGR02169  472 YDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERYATAIEVAAGNRln 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    941 -------KVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYApiVSFEECERKFkatekelkdqlsEQT 1013
Cdd:TIGR02169  551 nvvveddAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKY------------EPA 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1014 QKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRDKTVLIEKSH--------------EMERALSRKTDELNKQLKDLSQ 1077
Cdd:TIGR02169  616 FKYVFGDTLVVEDIEAARRLmgKYRMVTLEGELFEKSGAMTGGSraprggilfsrsepAELQRLRERLEGLKRELSSLQS 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1078 KYTEVKN-VKEKL--VEENAKQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Cdd:TIGR02169  696 ELRRIENrLDELSqeLSDASRKIGEIEKEIEQLEQEEEKlkerLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1151 KLHQLLEN--QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSK 1228
Cdd:TIGR02169  776 KLEEALNDleARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI----KS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1229 YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEllhfSIEQEIKDQKERCDKSLTTITELQRRIQ 1308
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR----ELERKIEELEAQIEKKRKRLSELKAKLE 927

                          810       820
                   ....*....|....*....|.
gi 59850762   1309 ESAKQIEAKDNKITELLNDVE 1329
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPE 948
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
460-982 6.18e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.48  E-value: 6.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   460 RLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEaasgnhRLT 539
Cdd:PRK03918  229 EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS------EFY 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQnemiVEEFKRDEGKLIEENKRLQKELSMCEmEREKKGRKVTEMEGQAKEL 619
Cdd:PRK03918  303 EEYLDELREIEKRLSRLEEEINGIEERIKE----LEEKEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERL 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   620 SAKLAlSIPAEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Cdd:PRK03918  378 KKRLT-GLTPEKLEKELEELEKakeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   697 KSGELGKKITEL-TLKNQTLQKEIEKVYLDNKLLKEQAhnlTIEMKNHYVPLKVSEDMKKSHDAiiddlnrklldvtQKY 775
Cdd:PRK03918  457 YTAELKRIEKELkEIEEKERKLRKELRELEKVLKKESE---LIKLKELAEQLKELEEKLKKYNL-------------EEL 520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ-EKIHALTSENTNLKKM 854
Cdd:PRK03918  521 EKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPF 600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   855 MsNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL-ENTQNQIKAEYISLAEHEAKMS 933
Cdd:PRK03918  601 Y-NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEELREEYLELSRELAGLR 679

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 59850762   934 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 982
Cdd:PRK03918  680 AELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE 728
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 490-1286 1.49e-11

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 69.70  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    490 EQIKQLEDALKDVQKRMYESegKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
Cdd:TIGR01612  974 DKINELDKAFKDASLNDYEA--KNNELIKYFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHT 1051

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    570 NEM-IVEEFKRDEGKLIEE-NKRLQKE--LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIpaEKFENMKSSLSNEVNE 645
Cdd:TIGR01612 1052 SIYnIIDEIEKEIGKNIELlNKEILEEaeINITNFNEIKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDH 1129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    646 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ----VKSRLEQKSG---ELGKKITELTL--KNQTLQ 716
Cdd:TIGR01612 1130 HIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDPEEIEKkienIVTKIDKKKNiydEIKKLLNEIAEieKDKTSL 1209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    717 KEIEKVYLD-----NKLLKEQAHnltiEMKnhyvplKVSEDMKKSHDAIIDDLNrkllDVTQKYTEKKLEMEKLLLENds 791
Cdd:TIGR01612 1210 EEVKGINLSygknlGKLFLEKID----EEK------KKSEHMIKAMEAYIEDLD----EIKEKSPEIENEMGIEMDIK-- 1273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    792 lskdvSRLETVFVPPEKHEKEIIALKSNivelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 871
Cdd:TIGR01612 1274 -----AEMETFNISHDDDKDHHIISKKH----DENISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLY 1344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    872 LNDTLAKTN-RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA--EYISLAEHEAKMSSLSQSmrkvQDSNaE 948
Cdd:TIGR01612 1345 LNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKikDDINLEECKSKIESTLDD----KDID-E 1419

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    949 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIvsfEECERKFKATEKELKD-----------QLSEQTQKYS 1017
Cdd:TIGR01612 1420 CIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNI---EMADNKSQHILKIKKDnatndhdfninELKEHIDKSK 1496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1018 VSEEEVKKNKQENDKlKKEIFTLQKdlRDKTVLIEKSHEMEralsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
Cdd:TIGR01612 1497 GCKDEADKNAKAIEK-NKELFEQYK--KDVTELLNKYSALA-----IKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSE 1568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1098 SEIlavqNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQrcyekeqqtvTKLHQLLENQKNSSVPLAEhlqiKEAFE 1177
Cdd:TIGR01612 1569 QKI----KEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFE----------NKFLKISDIKKKINDCLKE----TESIE 1630

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1178 KEVGIIkaSLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRevvdlskyKATKSDLETQISSLNEKLANLNRKYE-- 1255
Cdd:TIGR01612 1631 KKISSF--SIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEig 1700

                          810       820       830
                   ....*....|....*....|....*....|...
gi 59850762   1256 --EVCEEVLHAKKKEISAKdeKELLHFSIEQEI 1286
Cdd:TIGR01612 1701 iiEKIKEIAIANKEEIESI--KELIEPTIENLI 1731
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 654-1333 2.22e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.51  E-value: 2.22e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPE-EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 732
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLnKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    733 AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtqkyTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKE 812
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI-------KKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    813 IIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDVKKK 889
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQ--------------LKDNIEKKQQEINEKTTE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    890 FEDINQEFVKIKDKNEILKRNLENTQNQIKaeyislaEHEAKMSSLSQsmrKVQDSNAEILA-NYRKGQEEIVTLHAEIK 968
Cdd:TIGR04523  248 ISNTQTQLNQLKDEQNKIKKQLSEKQKELE-------QNNKKIKELEK---QLNQLKSEISDlNNQKEQDWNKELKSELK 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    969 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK-------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1041
Cdd:TIGR04523  318 NQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1042 KDLRDKTVLiekshemeralsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIlavQNLLQKQHVpleqVEALK 1121
Cdd:TIGR04523  398 SKIQNQEKL--------------NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEI---KDLTNQDSV----KELII 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNkmeEV 1201
Cdd:TIGR04523  457 KNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES---EK 533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1202 SKLQSEVQNTKQALKKLETRevvdlskykATKSDLETQISSLNEKLanlnrkyeevcEEVLHAKKKEISAKDEKELLHFS 1281
Cdd:TIGR04523  534 KEKESKISDLEDELNKDDFE---------LKKENLEKEIDEKNKEI-----------EELKQTQKSLKKKQEEKQELIDQ 593

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 59850762   1282 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1333
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-194 3.40e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.00  E-value: 3.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    46 DVEKVTSILAKKGVNPGKLDVEGRSVFHV--VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA------LCL 117
Cdd:PHA03100   84 DVKEIVKLLLEYGANVNAPDNNGITPLLYaiSKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   118 QK------------LLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 185
Cdd:PHA03100  164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                  ....*....
gi 59850762   186 LIDRGADVN 194
Cdd:PHA03100  244 LLNNGPSIK 252
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-270 5.19e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 5.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    37 RLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALC 116
Cdd:PHA02876  147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   117 LQKLLQYNCPTEHADLQGRTALHDaamADCPSSIqLLCDHGASVNAKDVDGRTPLVLATQMsrPTICQL---LIDRGADV 193
Cdd:PHA02876  227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762   194 NSRDKQNRTALMLGCEYGC-RDAVEVLIKNGADISLLDALGHDSSYYARIGD-NLDILTLLKTASENTNkGRELWKKGP 270
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-236 1.20e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.24  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    38 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYG-HAL 115
Cdd:PHA02876  277 LHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKD 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   116 CLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP-TICQLLIDRGADVN 194
Cdd:PHA02876  357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVN 436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 59850762   195 SRDKQNRTALMLGCEYGCR-DAVEVLIKNGADIS---------LLDALGHDS 236
Cdd:PHA02876  437 SKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNainiqnqypLLIALEYHG 488
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 442-1211 1.22e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 66.30  E-value: 1.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    442 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 521
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    522 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 596
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    597 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 676
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    677 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 751
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    752 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 830
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    831 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    905 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 983
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    984 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1052
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1053 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1128
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1199
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 59850762   1200 EVSKLQSEVQNT 1211
Cdd:pfam15921  831 EQESVRLKLQHT 842
PHA03095 PHA03095
ankyrin-like protein; Provisional
 119-234 2.34e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   119 KLLQYNCPTEHADLQGRTALH---DAAMADCPSSIQLLCDHGASVNAKDVDGRTPL-VLATQMSRPTICQLLIDRGADVN 194
Cdd:PHA03095   32 RLLAAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVN 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 59850762   195 SRDKQNRTALMLGCEYGCRDA--VEVLIKNGADISLLDALGH 234
Cdd:PHA03095  112 AKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGM 153
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-261 2.57e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    38 LMKAAERGDVEKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCL 117
Cdd:PHA02874  128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   118 QKLLQYNCPTEHADLQGRTALHDAAMADcPSSIQLLCDHgASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGADVNSR 196
Cdd:PHA02874  207 KLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIK 284

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762   197 DKQNRTALMLGCEYGCRDAV-------EVLIKNGADISLLDALGHDSsyyarIGDNLDILTLLKTASENTNK 261
Cdd:PHA02874  285 DNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-229 2.63e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    53 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGV---DITTSDtaGRNALHLAAKYGHALCLQKLLQYNCPTEH 129
Cdd:PHA02875   53 LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   130 ADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM-LGC 208
Cdd:PHA02875  131 PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAI 210

                         170       180
                  ....*....|....*....|.
gi 59850762   209 EYGCRDAVEVLIKNGADISLL 229
Cdd:PHA02875  211 ENNKIDIVRLFIKRGADCNIM 231
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 482-1319 3.36e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 3.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    482 ERVKEDSDEQIKqledalkDVQKRMYES------------------EGKVKQMQTHFLALKEHLTSEAASgnhrlTEELK 543
Cdd:pfam15921   77 ERVLEEYSHQVK-------DLQRRLNESnelhekqkfylrqsvidlQTKLQEMQMERDAMADIRRRESQS-----QEDLR 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    544 DQLKDLKVKYEGA-SAEVGKLRNQIKQNEMIVEEFKRDEGKlieenkrLQKELSMCEMEREKKGRKVTEMEgqakelsak 622
Cdd:pfam15921  145 NQLQNTVHELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGV-------LQEIRSILVDFEEASGKKIYEHD--------- 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    623 lalSIPAEKFENMKSSLSnevnekaKKLVEMEREHEKSLSEIRQLKRELENVKAKlAQHVKPEEHEQVKSRLEQKSGELG 702
Cdd:pfam15921  209 ---SMSTMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSE-SQNKIELLLQQHQDRIEQLISEHE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS--------EDMKKSHDAIIDDLNRKLLDVTQK 774
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTvsqlrselREAKRMYEDKIEELEKQLVLANSE 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    775 YTEKKLEMEKLLLENDSLSkdvSRLETVFVPPEKHEKEIialksnivelkkQLSELKKKCGEDQEKIHALTSEntNLKKM 854
Cdd:pfam15921  358 LTEARTERDQFSQESGNLD---DQLQKLLADLHKREKEL------------SLEKEQNKRLWDRDTGNSITID--HLRRE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    855 MSNQYVPVKTHEEVKMTL-NDTLAKTNRELLDVKKKFEDInQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMS 933
Cdd:pfam15921  421 LDDRNMEVQRLEALLKAMkSECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVS 499

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    934 SLSQSM----RKVQDSNAEIlanyRKGQEEIVTLHAEIKAQKKELDTIQECIKvkyapivsfeECER-KFKATEKE---- 1004
Cdd:pfam15921  500 DLTASLqekeRAIEATNAEI----TKLRSRVDLKLQELQHLKNEGDHLRNVQT----------ECEAlKLQMAEKDkvie 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1005 -LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL----SQKY 1079
Cdd:pfam15921  566 iLRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagSERL 645

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1080 TEVKNVKE---KLVEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKlhqlL 1156
Cdd:pfam15921  646 RAVKDIKQerdQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKS----M 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1157 ENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSKYKATKSD 1235
Cdd:pfam15921  719 EGSDGHAMKVAMGMQKQiTAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEK----NKMAGELEV 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1236 LETQISSLNEKLANLNRKYEEVceEVLHAKKKEISAKDEKELLHFSIEQEIkDQKERCDKSLTTITELQRRIQESAKQIE 1315
Cdd:pfam15921  795 LRSQERRLKEKVANMEVALDKA--SLQFAECQDIIQRQEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTR 871


                   ....
gi 59850762   1316 AKDN 1319
Cdd:pfam15921  872 THSN 875
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 489-1302 5.47e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.89  E-value: 5.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSeaasgnhrlteeLKDQLKDLKvkyegasAEVGKLRNQIK 568
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN------------SNNKIKILE-------QQIKDLNDKLK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    569 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLSNEVNEKAK 648
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI------KKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    649 KLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvyldnkl 728
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLL---KLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEK------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    729 LKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQkyTEKKLemeklllenDSLSKDVSRLETVF--VPP 806
Cdd:TIGR04523  237 KQQEINEKTTEISNTQTQLN---QLKDEQNKIKKQLSEKQKELEQ--NNKKI---------KELEKQLNQLKSEIsdLNN 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    807 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 886
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN--------------SESENSEKQRELEEK 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    887 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQsmrkvqdsnaeilaNYRKGQEEIVTLHAE 966
Cdd:TIGR04523  369 QNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ--------------EKELLEKEIERLKET 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    967 IKAQKKELDTIQECIKVKyapivsfeecerkfKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLrd 1046
Cdd:TIGR04523  435 IIKNNSEIKDLTNQDSVK--------------ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL-- 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1047 ktvliekshemeRALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL--EQVEALKKSL 1124
Cdd:TIGR04523  499 ------------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEK 566

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1125 NGTIENLKEELKSMQRCYEKEQQtvtKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1204
Cdd:TIGR04523  567 NKEIEELKQTQKSLKKKQEEKQE---LIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1205 QSEVQNTKQALKKLetrevvdlskyKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL------ 1278
Cdd:TIGR04523  644 KQEVKQIKETIKEI-----------RNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLpkleek 712

                          810       820
                   ....*....|....*....|....
gi 59850762   1279 HFSIEQEIKDQKErCDKSLTTITE 1302
Cdd:TIGR04523  713 YKEIEKELKKLDE-FSKELENIIK 735
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-252 5.77e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 5.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    72 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHADLQGRTALHDAAMADC 146
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   147 --PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT--ICQLLIDRGADVN----------------SRDKQNRTALML 206
Cdd:PHA03100  119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHY 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 59850762   207 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 252
Cdd:PHA03100  199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 958-1368 7.01e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.89  E-value: 7.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    958 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY-------SVSEEEVKKNKQEN 1030
Cdd:TIGR04523   40 KKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKInklnsdlSKINSEIKNDKEQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1031 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1110
Cdd:TIGR04523  120 NKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKL 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1111 HVPLEQVEALK---KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNssvplaEHLQIKEAFEKevgiIKASL 1187
Cdd:TIGR04523  200 ELLLSNLKKKIqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT------QLNQLKDEQNK----IKKQL 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1188 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY--------KATKSDLETQISSLNEKLANLNRKYEEVCE 1259
Cdd:TIGR04523  270 SEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1260 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL---TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1336
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKnleSQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 59850762   1337 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1368
Cdd:TIGR04523  430 RLKETIIKNNSEIKDLTNQDSVKELIIKNLDN 461
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 80-240 1.00e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 1.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    80 NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGAS 159
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   160 VNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLIKNgADISLLDALGHDSSYY 239
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                  .
gi 59850762   240 A 240
Cdd:PHA02874  261 A 261
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 779-1370 1.02e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.60  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    779 KLEMEKLLLENDSLSKDVSRleTVFVPPEKHEKEIIALKSNIVELKKQLSELK-------------KKCGED-----QEK 840
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirrreSQSQEDlrnqlQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    841 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDV-----KKKFEDINQEFVKIKDKNEILKRNLENTQ 915
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFeeasgKKIYEHDSMSTMHFRSLGSAISKILRELD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    916 NQI---KAEYISLAEHEAKMSSLSQS-----MRKVQDSNAEILANYrkgQEEIVTLHAEIKAQKKELDTIQ---ECIKVK 984
Cdd:pfam15921  231 TEIsylKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQsqlEIIQEQ 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    985 YAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendkLKKEIFTLQKDLRDKtvLIEKSHEMERALSR 1063
Cdd:pfam15921  308 ARNQNSMYMRQlSDLESTVSQLRSELREAKRMYEDKIEELEKQLV----LANSELTEARTERDQ--FSQESGNLDDQLQK 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1064 KTDELNKQLKDLSQKytevKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1143
Cdd:pfam15921  382 LLADLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1144 KEQQTVTKLHQLLENQKNSSVPLAEHLQIK----EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1219
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1220 TREvVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ---EIKDQKERCDKS 1296
Cdd:pfam15921  538 NEG-DHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDrrlELQEFKILKDKK 616

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1297 LTTITELQRRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ----LTYTSGNPTKRQSQLIDT 1358
Cdd:pfam15921  617 DAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEMETTTNK 696

                          650
                   ....*....|..
gi 59850762   1359 LQHQVKSLEQQL 1370
Cdd:pfam15921  697 LKMQLKSAQSEL 708
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 630-1376 1.06e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    630 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQlkrELENVKAKLAQHVKPEEHEQVKSRLEQKSGElgkkitelT 709
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQ---SVIDLQTKLQEMQMERDAMADIRRRESQSQE--------D 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    710 LKNQtLQKEIEKVYLdNKLLKEQAhnltieMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKklemeklLLEN 789
Cdd:pfam15921  143 LRNQ-LQNTVHELEA-AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK-------IYEH 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    790 DSLSKdvsrletvfvppeKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvktHEEv 868
Cdd:pfam15921  208 DSMST-------------MHFRSLGSAISKILrELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQ------HQD- 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    869 kmTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKrnlENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 948
Cdd:pfam15921  268 --RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQ---EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    949 ILANYRKgqeEIVTLHAEIKAQKKELDtiqecikvkyapivsfeecerKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1028
Cdd:pfam15921  343 KIEELEK---QLVLANSELTEARTERD---------------------QFSQESGNLDDQLQKLLADLHKREKELSLEKE 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1029 ENDKL-------KKEIFTLQKDLRDKTVLIEKsheMERALSRKTDELNKQLKdlsQKYTEVKNVKEKLvEENAKQTSEIL 1101
Cdd:pfam15921  399 QNKRLwdrdtgnSITIDHLRRELDDRNMEVQR---LEALLKAMKSECQGQME---RQMAAIQGKNESL-EKVSSLTAQLE 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1102 AVQNLLQKQhvpLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLH-------QLLENQKNSsvplAEHLQ 1171
Cdd:pfam15921  472 STKEMLRKV---VEELTAKKMTLESserTVSDLTASLQEKERAIEATNAEITKLRsrvdlklQELQHLKNE----GDHLR 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1172 IKEAfekEVGIIKASLREKE---EESQNKMEEVSKLQSE-------VQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
Cdd:pfam15921  545 NVQT---ECEALKLQMAEKDkviEILRQQIENMTQLVGQhgrtagaMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIR 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1242 SLNEKLANLNRKyeevceevlhaKKKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITE----LQRRIQESAKQI 1314
Cdd:pfam15921  622 ELEARVSDLELE-----------KVKLVNAGSERLRAVKDIKQErdqLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEM 690

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59850762   1315 EAKDNKITELLNDVE-RLKQALNGLSQLTYTSGNPTK----RQSQL------IDTLQHQVKSLEQQLADADRQ 1376
Cdd:pfam15921  691 ETTTNKLKMQLKSAQsELEQTRNTLKSMEGSDGHAMKvamgMQKQItakrgqIDALQSKIQFLEEAMTNANKE 763
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 927-1278 1.32e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.15  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    927 EHEAKMSSLSQSMRKVQDSNAEILANYRK--GQEEIVTLHAEIKAQKKELDtiqecIKVKYAPIVSFEECERKFKATEKE 1004
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSleRQAEKAERYKELKAELRELE-----LALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1005 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1084
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1085 VKEKLVEEnakqtseilavqnllqkqhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsv 1164
Cdd:TIGR02168  331 KLDELAEE---------------------LAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSK-- 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1165 pLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNtkQALKKLETRevvdLSKYKATKSDLETQISSLN 1244
Cdd:TIGR02168  388 -VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAE----LEELEEELEELQEELERLE 460

                          330       340       350
                   ....*....|....*....|....*....|....
gi 59850762   1245 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1278
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSL 494
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1041-1414 1.57e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1041 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1120
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1121 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
Cdd:COG1196  301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1201 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1280
Cdd:COG1196  374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1281 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1360
Cdd:COG1196  441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 59850762 1361 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1414
Cdd:COG1196  513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
PTZ00121 PTZ00121
MAEBL; Provisional
 328-912 1.63e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   328 QLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGShfSNRKEDMLLKQGQMYMADSQ 407
Cdd:PTZ00121 1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAE--AEAAADEAEAAEEKAEAAEK 1371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   408 CTS----PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ-------DRLKLQNELAHKVAECKA 476
Cdd:PTZ00121 1372 KKEeakkKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKaeekkkaDEAKKKAEEAKKADEAKK 1451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   477 LALECERVKE--DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKY 553
Cdd:PTZ00121 1452 KAEEAKKAEEakKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaEEAKKADEAKKAE 1531

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   554 EGASAEVGKLRNQIKQNEMI--VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEK 631
Cdd:PTZ00121 1532 EAKKADEAKKAEEKKKADELkkAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   632 F-----ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIT 706
Cdd:PTZ00121 1612 AkkaeeAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   707 ELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE-----MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLE 781
Cdd:PTZ00121 1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeenkIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAE 1771

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   782 MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELkkkCGEDQEKIHALTSENTNLKKMMSNQYVP 861
Cdd:PTZ00121 1772 EIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLV---INDSKEMEDSAIKEVADSKNMQLEEADA 1848

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 59850762   862 VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLE 912
Cdd:PTZ00121 1849 FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIE 1899
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 912-1388 2.26e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.05  E-value: 2.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    912 ENTQNQIKAEYISLAEHEAKMSSLSQSMRkVQDSNAEILANYRKGQEEIVTLHAEiKAQKKELDTIQECIKVKYAPIVSF 991
Cdd:pfam05483  175 EYEREETRQVYMDLNNNIEKMILAFEELR-VQAENARLEMHFKLKEDHEKIQHLE-EEYKKEINDKEKQVSLLLIQITEK 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    992 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI----FTLQKDLRDKTVLIEKSHEMERALSRKTDE 1067
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALEEDLQIATKTICQLTEE 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1068 LNKQLKDLSQKYTEVKNVKEKLveenakqTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE---- 1143
Cdd:pfam05483  333 KEAQMEELNKAKAAHSFVVTEF-------EATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNnkev 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1144 --KEQQTVTKLHQLLENQKNSSVPLAEHLQIKE--------AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKq 1213
Cdd:pfam05483  406 elEELKKILAEDEKLLDEKKQFEKIAEELKGKEqelifllqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK- 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1214 aLKKLETREVVDL-----SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKD 1288
Cdd:pfam05483  485 -LKNIELTAHCDKlllenKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1289 QKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1368
Cdd:pfam05483  564 VKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLEL 643

                          490       500
                   ....*....|....*....|
gi 59850762   1369 QLADADRQHQEVIAIYRTHL 1388
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEI 663
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 462-1139 2.53e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 2.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    462 KLQNELAHKVAECKAL---ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNhrl 538
Cdd:TIGR04523   44 TIKNELKNKEKELKNLdknLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN--- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    539 teELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEgqaKE 618
Cdd:TIGR04523  121 --KLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK---NK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    619 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKS 698
Cdd:TIGR04523  196 LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK--DEQNKIKKQLSEKQ 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    699 GEL---GKKITELTLKNQTLQKEIEKvyLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Cdd:TIGR04523  274 KELeqnNKKIKELEKQLNQLKSEISD--LNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKEL 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    776 TEKKLEMEKLlleNDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
Cdd:TIGR04523  352 TNSESENSEK---QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 935
Cdd:TIGR04523  429 ERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKEL 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    936 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIqecikvkyapivsfeecerkfkatekelkdqlsEQTQK 1015
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD---------------------------------DFELK 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1016 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1095
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQ-------KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 59850762   1096 QTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ 1139
Cdd:TIGR04523  629 LSSII---KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669
PTZ00121 PTZ00121
MAEBL; Provisional
 888-1333 4.44e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.31  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   888 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDsNAEILANYRKGQEEIVTLHAEI 967
Cdd:PTZ00121 1194 RKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN-NEEIRKFEEARMAHFARRQAAI 1272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   968 KAQ-KKELDTIQECIKVKYAPIVSFEECERKF-----KATEKELKDQLSEQTQKYSVSEEEVKKNKQENdklKKEIFTLQ 1041
Cdd:PTZ00121 1273 KAEeARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA---KKAAEAAK 1349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1042 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--KLVEENAKQTSEILAVQNLLQKQHVPLEQVEA 1119
Cdd:PTZ00121 1350 AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEakKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1120 LKKSlngtiENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQiKEAFEKEVGiikASLREKEEESQNKME 1199
Cdd:PTZ00121 1430 KKKA-----DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKA---DEAKKKAEEAKKKAD 1500

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1200 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEV--CEEVLHAKKKEiSAKDEKEL 1277
Cdd:PTZ00121 1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL-KKAEELkkAEEKKKAEEAK-KAEEDKNM 1578

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762  1278 LHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1333
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 150-247 5.65e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 5.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLL 229
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                          90
                  ....*....|....*...
gi 59850762   230 DALGHDSSYYARIGDNLD 247
Cdd:PTZ00322  178 GANAKPDSFTGKPPSLED 195
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-222 3.26e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    49 KVTSILAKKGVNPGKLDVE-GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 127
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   128 EHADLQGRTALHdAAMADCPSS--IQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTicQLLIDRGADVNSRDKQNRTAL 204
Cdd:PHA02878  228 DARDKCGNTPLH-ISVGYCKDYdiLKLLLEHGVDVNAKSyILGLTALHSSIKSERKL--KLLLEYGADINSLNSYKLTPL 304

                         170
                  ....*....|....*....
gi 59850762   205 -MLGCEYGCRDAVEVLIKN 222
Cdd:PHA02878  305 sSAVKQYLCINIGRILISN 323
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 41-257 5.07e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 5.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    41 AAERGDVeKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHlaakygHALCLQKL 120
Cdd:PHA02876  185 AAERGNA-KMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIR------NEDLETSL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   121 LQYNC--PTEHADLQGRTALHDAAMAdcPSSIQL---LCDHGASVNAKDVDGRTPLVLATQMSRPTI-CQLLIDRGADVN 194
Cdd:PHA02876  258 LLYDAgfSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVN 335

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 59850762   195 SRDKQNRTALMLGCEYG-CRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDIL-TLLKTASE 257
Cdd:PHA02876  336 AADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIInTLLDYGAD 400
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 564-1390 5.23e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.75  E-value: 5.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    564 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELS-MCEMEREKKGRKVT--EMEGQAKELSAKLALSIPA--EKFENMKSS 638
Cdd:TIGR00606  230 EAQLESSREIVKSYENELDPLKNRLKEIEHNLSkIMKLDNEIKALKSRkkQMEKDNSELELKMEKVFQGtdEQLNDLYHN 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    639 LSNEVNEKAKKLVEMEREHEKSLSEIRQL---KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI--------TE 707
Cdd:TIGR00606  310 HQRTVREKERELVDCQRELEKLNKERRLLnqeKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELdgfergpfSE 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    708 LTLKN-QTLQKE--IEKVYLDNKLLKEQAHNLTIEMKNhyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
Cdd:TIGR00606  390 RQIKNfHTLVIErqEDEAKTAAQLCADLQSKERLKQEQ----ADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQ 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    785 LLLENDSLSKDVSRLETVFVPPEKHEKE--IIALKSNIVELK-KQLSELKKKCGEDQEkIHALTSENTNLKKMMSNQYVP 861
Cdd:TIGR00606  466 LEGSSDRILELDQELRKAERELSKAEKNslTETLKKEVKSLQnEKADLDRKLRKLDQE-MEQLNHHTTTRTQMEMLTKDK 544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    862 VKTHEEV--------------------KMTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneilkrnLENTQNQIKAE 921
Cdd:TIGR00606  545 MDKDEQIrkiksrhsdeltsllgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELAS-----------LEQNKNHINNE 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    922 YISLaehEAKMSSLSQSMRKVQDSNAEilanyrkgQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE-------- 993
Cdd:TIGR00606  614 LESK---EEQLSSYEDKLFDVCGSQDE--------ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpv 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    994 CERKFKaTEKELKDQLSEQTQKYSV-------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1066
Cdd:TIGR00606  683 CQRVFQ-TEAELQEFISDLQSKLRLapdklksTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQ 761

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1067 ELNKQLKDlSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT----------------IEN 1130
Cdd:TIGR00606  762 RLKNDIEE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDrtvqqvnqekqekqheLDT 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1131 LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiikasLREKEEESQNKMEEVSKLQSEVQN 1210
Cdd:TIGR00606  841 VVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ-------LVELSTEVQSLIREIKDAKEQDSP 913

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1211 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEISA------------ 1271
Cdd:TIGR00606  914 LETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNihgymkdIENKIQDGKDDYLKQKETELNTvnaqleecekhq 993

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1272 -KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQALNGLSQLTYTSGNPTK 1350
Cdd:TIGR00606  994 eKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQM--QVLQMKQEHQKLEENIDLIKRNHV 1071

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 59850762   1351 ----RQSQLIDTLQHQVKSL-EQQLADADRQHQEVIAIYRTHLLS 1390
Cdd:TIGR00606 1072 lalgRQKGYEKEIKHFKKELrEPQFRDAEEKYREMMIVMRTTELV 1116
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 648-1341 5.35e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 57.67  E-value: 5.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    648 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKsgELGKKITELTLKNQTLQKEIEKVYLDNK 727
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEK--LELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    728 LLKEQAHNLTI-EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVfvpP 806
Cdd:pfam02463  247 RDEQEEIESSKqEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE---K 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    807 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE----VKMTLNDTLAKTNRE 882
Cdd:pfam02463  324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESErlssAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    883 LLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEKKEELEILEEEEesIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    961 VTLHAEIKAQKKELDTIQEC----------IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1030
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESkarsglkvllALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1031 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI-------- 1100
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTklkesaka 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1101 --------------------LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1160
Cdd:pfam02463  644 kesglrkgvsleeglaekseVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1161 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLE 1237
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLkveEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR--IQESAKQIE 1315
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELllKEEELEEQK 883

                          730       740
                   ....*....|....*....|....*.
gi 59850762   1316 AKDNKITELLNDVERLKQALNGLSQL 1341
Cdd:pfam02463  884 LKDELESKEEKEKEEKKELEEESQKL 909
PRK01156 PRK01156
chromosome segregation protein; Provisional
 633-1220 5.42e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 57.60  E-value: 5.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   633 ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaQHVKPEEHE-----QVKSRLEQKSGELGKKITE 707
Cdd:PRK01156  189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY-NNLKSALNElssleDMKNRYESEIKTAESDLSM 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   708 LTLKNQTLqKEIEKVYldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-----KLLDVTQKYTEKKLEM 782
Cdd:PRK01156  268 ELEKNNYY-KELEERH--MKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKyhaiiKKLSVLQKDYNDYIKK 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   783 EKlllENDSLSKDVSRLETvfvppekHEKEIIALKSNIVELKKQLSELKKKcgedQEKIHALTSENtnLKKMMSNQYVPV 862
Cdd:PRK01156  345 KS---RYDDLNNQILELEG-------YEMDYNSYLKSIESLKKKIEEYSKN----IERMSAFISEI--LKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   863 KTHEEVkmtlndtlaktNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKV 942
Cdd:PRK01156  409 KELNEI-----------NVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHI---INHY 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   943 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEcikvkyAPIVSFEECERKFKATEKELKD------QLSEQTQKY 1016
Cdd:PRK01156  475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES------EEINKSINEYNKIESARADLEDikikinELKDKHDKY 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDkTVLIEkshemerALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1096
Cdd:PRK01156  549 EEIKNRYKSLKLEDLDSKRTSWLNALAVIS-LIDIE-------TNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKS 620

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1097 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqikeaf 1176
Cdd:PRK01156  621 IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKS-------------- 686

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 59850762  1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1220
Cdd:PRK01156  687 RKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKK 730
Ank_4 pfam13637
Ankyrin repeats (many copies);
134-187 7.59e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 7.59e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 59850762    134 GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLI 187
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 294-1038 8.15e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 8.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    294 QNIQDLEIENEDLKE----RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 369
Cdd:TIGR02169  198 QQLERLRREREKAERyqalLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    370 KNRFKyfesdHLGSGSHFSnRKEDMLLKQGQMYMADSQctspgipahmQSRSMLRPLELSLPSQTSYSENEILKKELEAM 449
Cdd:TIGR02169  278 NKKIK-----DLGEEEQLR-VKEKIGELEAEIASLERS----------IAEKERELEDAEERLAKLEAEIDKLLAEIEEL 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    450 RTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQThflaLKEH 526
Cdd:TIGR02169  342 EREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQE----ELQR 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    527 LTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEME----- 601
Cdd:TIGR02169  418 LSEELADLNAAI-AGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRElaeae 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    602 --------REKKGRKVTEMEGQ------------------------------------------------AKELSAKLAL 625
Cdd:TIGR02169  497 aqaraseeRVRGGRAVEEVLKAsiqgvhgtvaqlgsvgeryataievaagnrlnnvvveddavakeaielLKRRKAGRAT 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    626 SIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLSEIRQ---LKRELENVKAKLAQ------------------ 680
Cdd:TIGR02169  577 FLPLNKMRDERRDLSilseDGVIGFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAARRLMGKyrmvtlegelfeksgamt 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    681 --HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVyldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 758
Cdd:TIGR02169  657 ggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRI---ENRLDELSQELSDASRKIGEIEKEIEQLEQEEE 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    759 A---IIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH---------EKEIIALKSNIVELKKQ 826
Cdd:TIGR02169  734 KlkeRLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsripeiQAELSKLEEEVSRIEAR 813

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    827 LSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI 906
Cdd:TIGR02169  814 LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    907 LK---RNLENTQNQIKAEYISLAEHeakMSSLSQSMRKVQDSNAEILANYRKGQEE------IVTLHAEIKAQKKELDTI 977
Cdd:TIGR02169  894 LEaqlRELERKIEELEAQIEKKRKR---LSELKAKLEALEEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRAL 970

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762    978 QEcikVKYAPIVSFEECERKFkatekelkDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1038
Cdd:TIGR02169  971 EP---VNMLAIQEYEEVLKRL--------DELKEKRAKLEEERKAILERIEEYEKKKREVF 1020
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 287-1369 8.69e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 57.37  E-value: 8.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    287 KSHQREHQNIQDLEIENEDLK------ERLRKIQQEQRILLDKVNGLQLQLNEEVMVAddlESEREKLKSLLAAKEKQHE 360
Cdd:TIGR01612  904 KSIEEEYQNINTLKKVDEYIKicentkESIEKFHNKQNILKEILNKNIDTIKESNLIE---KSYKDKFDNTLIDKINELD 980

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    361 E-----SLRTIEALKNRF-KYFESDHLGSGSHfsnrKEDMLLKQ------------GQMYMADSQCTSPGIPAHMQSRSM 422
Cdd:TIGR01612  981 KafkdaSLNDYEAKNNELiKYFNDLKANLGKN----KENMLYHQfdekekatndieQKIEDANKNIPNIEIAIHTSIYNI 1056

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    423 LRPLELSLPSQTSYSENEILKKELEAMRTFCESakQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 502
Cdd:TIGR01612 1057 IDEIEKEIGKNIELLNKEILEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKAL 1134

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    503 QKRMYESEGKVKQMQTHFLALkEHLTSEAASGNHrlTEELKDQLKDLKVKYEGAS---AEVGKLRNQIKQNEMIVEEFKR 579
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDL-EDVADKAISNDD--PEEIEKKIENIVTKIDKKKniyDEIKKLLNEIAEIEKDKTSLEE 1211

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    580 DEGKLIEENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKEL------SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVE 652
Cdd:TIGR01612 1212 VKGINLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLdeikekSPEIENEMGIEMDIKAEMETFNISHDDDKDHHI 1291

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    653 MEREHEKSLSEIRQ--LKRELENVKAKLAQHVKPEEHEQVkSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLD 725
Cdd:TIGR01612 1292 ISKKHDENISDIREksLKIIEDFSEESDINDIKKELQKNL-LDAQKHNSDINLYLNEIAniyniLKLNKIKKIIDEVKEY 1370

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    726 NKLLKEQAHNLTIEMKNHYVPLKVSED---MKKSHDAIIDDLNRKLLD-VTQKYTEKKLEMEKLLLENDSL-------SK 794
Cdd:TIGR01612 1371 TKEIEENNKNIKDELDKSEKLIKKIKDdinLEECKSKIESTLDDKDIDeCIKKIKELKNHILSEESNIDTYfknadenNE 1450

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    795 DVSRLETVFVPPEKHEKEIIALKS---------NIVELKKQLSElKKKCGEDQEKIHALTSENTNLKK-------MMSNQ 858
Cdd:TIGR01612 1451 NVLLLFKNIEMADNKSQHILKIKKdnatndhdfNINELKEHIDK-SKGCKDEADKNAKAIEKNKELFEqykkdvtELLNK 1529

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    859 YVPVKTHEEVKMTLNDTLAKTNrELLDVKKKF----EDINQEFVKIKDKNEILKRNLENTQNQIKAEY---ISLAEHEAK 931
Cdd:TIGR01612 1530 YSALAIKNKFAKTKKDSEIIIK-EIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIdiqLSLENFENK 1608

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    932 MSSLSQSMRKVQDSNAEILANYRK-GQEEIVTLHAEIKAQKKELDTIQECIKvkyapivSFEECERKFKATEKELkDQLS 1010
Cdd:TIGR01612 1609 FLKISDIKKKINDCLKETESIEKKiSSFSIDSQDTELKENGDNLNSLQEFLE-------SLKDQKKNIEDKKKEL-DELD 1680

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1011 EQTQKYSVSEEEVKKNKQEN--DKLKKEIFTLQKDLRDKTVLIEKSheMERALS-------------RKTDELNKQLKDL 1075
Cdd:TIGR01612 1681 SEIEKIEIDVDQHKKNYEIGiiEKIKEIAIANKEEIESIKELIEPT--IENLISsfntndlegidpnEKLEEYNTEIGDI 1758

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1076 SQKYTEVKNV---------KEKLVEENAKQT-----SEILAVQNLLQKQHVPLEQVEAlkKSLNGTIENLKEELKSMQRC 1141
Cdd:TIGR01612 1759 YEEFIELYNIiagcletvsKEPITYDEIKNTrinaqNEFLKIIEIEKKSKSYLDDIEA--KEFDRIINHFKKKLDHVNDK 1836

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1142 YEKEQQTVTK----LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS----EVQNTkQ 1213
Cdd:TIGR01612 1837 FTKEYSKINEgfddISKSIENVKNSTDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIFINISKLANsiniQIQNN-S 1915

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1214 ALKKLETREVVDLSKYKATKSDLETQISSlNEKLANLNRKYEEVCEEVLHA-KKKEISAKDEKELLHFSIEQEIKDQKER 1292
Cdd:TIGR01612 1916 GIDLFDNINIAILSSLDSEKEDTLKFIPS-PEKEPEIYTKIRDSYDTLLDIfKKSQDLHKKEQDTLNIIFENQQLYEKIQ 1994

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762   1293 CDKSLttitelqrriQESAKQIEAKDNKItelLNDVERLKQALNGLSQLTYTSGN-PTKRQSQLIDTLQHQVKSLEQQ 1369
Cdd:TIGR01612 1995 ASNEL----------KDTLSDLKYKKEKI---LNDVKLLLHKFDELNKLSCDSQNyDTILELSKQDKIKEKIDNYEKE 2059
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-260 1.12e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    79 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGA 158
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   159 SVNakDV---DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHD 235
Cdd:PHA02875   93 FAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCT 170

                         170       180
                  ....*....|....*....|....*
gi 59850762   236 SSYYARIGDNLDILTLLKTASENTN 260
Cdd:PHA02875  171 PLIIAMAKGDIAICKMLLDSGANID 195
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 632-900 1.31e-07

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 56.09  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   632 FENMKSSLSNEVNEKAKKLVEMEREHeksLSEIRQLkRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 711
Cdd:PRK05771   33 IEDLKEELSNERLRKLRSLLTKLSEA---LDKLRSY-LPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   712 NQTLQKEIEKvYLDNKLLKEQAHNLTIEMKNHY-------VPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY------TEK 778
Cdd:PRK05771  109 ISELENEIKE-LEQEIERLEPWGNFDLDLSLLLgfkyvsvFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvVLK 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   779 KL--EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 856
Cdd:PRK05771  188 ELsdEVEEELKKLGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEYLEIELERAEALS 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762   857 NQ-----------YVPVKTHEEVKMTLNDTlakTNR----ELLDVKKKFEDI-----NQEFVKI 900
Cdd:PRK05771  268 KFlktdktfaiegWVPEDRVKKLKELIDKA---TGGsayvEFVEPDEEEEEVptklkNPKFIKP 328
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 438-831 1.80e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.89  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    438 ENEILKKeLEAMRTFCESAKQDRLKLQNELAHKvaeckalalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 517
Cdd:pfam15921  456 KNESLEK-VSSLTAQLESTKEMLRKVVEELTAK-----------KMTLESSERTVSDLTASLQEKERAIEATNAEITKLR 523

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    518 THF-LALKE--HLTSEAASGNHRLTEelkdqLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 594
Cdd:pfam15921  524 SRVdLKLQElqHLKNEGDHLRNVQTE-----CEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    595 LSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV 674
Cdd:pfam15921  599 INDRRLELQEFKILKDKKDAKIRELEARVS------DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSL 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    675 KaklaqhvkpEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIekvyldnkllkEQAHNLTIEMK-NHYVPLKVSEDM 753
Cdd:pfam15921  673 S---------EDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-----------EQTRNTLKSMEgSDGHAMKVAMGM 732

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    754 KKSHDAI---IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSrleTVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Cdd:pfam15921  733 QKQITAKrgqIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVANM 809


                   .
gi 59850762    831 K 831
Cdd:pfam15921  810 E 810
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 872-1371 1.87e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 1.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  872 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 951
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  952 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEND 1031
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1032 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqh 1111
Cdd:COG1196  397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-- 474

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1112 vpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHqLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL---- 1187
Cdd:COG1196  475 --LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL-LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1188 ---------REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-------------------LSKYKATKSDLETQ 1239
Cdd:COG1196  552 vveddevaaAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvLGDTLLGRTLVAAR 631

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1240 ISSLNEKLANLNRKYEEV---CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1316
Cdd:COG1196  632 LEAALRRAVTLAGRLREVtleGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762 1317 KDNKITELLNDVERLKQALNGLSQ-----------LTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1371
Cdd:COG1196  712 AEEERLEEELEEEALEEQLEAEREelleelleeeeLLEEEALEELPEPPDLEELERELERLEREIE 777
PTZ00121 PTZ00121
MAEBL; Provisional
 253-918 2.33e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.92  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   253 KTASENTNKGRELWKKGPSLQQRN-LTHMQDEVNVKSHQREHQNIQDLEIENEDLK---ERLRKIQQEQRilldKVNGLQ 328
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAeAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKkkaDAAKKKAEEKK----KADEAK 1397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   329 LQLNEEVMVADDLESEREKLKSLLAAKEKQhEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSqc 408
Cdd:PTZ00121 1398 KKAEEDKKKADELKKAAAAKKKADEAKKKA-EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE-- 1474

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   409 tspgipAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELahKVAECKALALECERVKEDS 488
Cdd:PTZ00121 1475 ------AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA--KKAEEAKKADEAKKAEEKK 1546

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   489 D-EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgnhRLTEELKDQLKDLKVKYEGA-SAEVGKLR-N 565
Cdd:PTZ00121 1547 KaDELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA---RIEEVMKLYEEEKKMKAEEAkKAEEAKIKaE 1623

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   566 QIKQNEMI---VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAklalsipAEKFENMKSSLSNE 642
Cdd:PTZ00121 1624 ELKKAEEEkkkVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK-------AEEDEKKAAEALKK 1696

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIteltlknQTLQKEIEKV 722
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKI-------AHLKKEEEKK 1769

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK--KSHDAIIDDLNRKlldvTQKYTEKKLEMEKLLLENDSLSKDVSRLE 800
Cdd:PTZ00121 1770 AEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKdiFDNFANIIEGGKE----GNLVINDSKEMEDSAIKEVADSKNMQLEE 1845

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   801 TVFVPPEKHEKEIIALKSNIvelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPvktheevkmtlNDTLAKTN 880
Cdd:PTZ00121 1846 ADAFEKHKFNKNNENGEDGN---KEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIP-----------NNNMAGKN 1911

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 59850762   881 RELLDVKkkfedinqefvkiKDKNEILKRNLENTQNQI 918
Cdd:PTZ00121 1912 NDIIDDK-------------LDKDEYIKRDAEETREEI 1936
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
905-1333 3.64e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 984
Cdd:PRK02224  254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   985 YAPIVSF-EECERKFKATE------KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEM 1057
Cdd:PRK02224  334 RVAAQAHnEEAESLREDADdleeraEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDF 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1058 ERALSRKTDELNKQLKDLSQKYTEVKNVKEK---LVE-----------ENAKQTSEILAVQNLLQKQHVPLEQVEALKKS 1123
Cdd:PRK02224  414 LEELREERDELREREAELEATLRTARERVEEaeaLLEagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVEE 493

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1124 LNGTIENLkEELKSMQRCYEKEQQTVTKLHQLLENQKNS----SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Cdd:PRK02224  494 VEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEARE 572

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1200 EVSKLQSEVQNTKQALKKLETREVVDlskykATKSDLETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLH 1279
Cdd:PRK02224  573 EVAELNSKLAELKERIESLERIRTLL-----AAIADAEDEIERLREKREALAELNDERRERL--AEKRERKRELEAEFDE 645

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  1280 FSIEqEIKDQKERCDKSLTTITELQRRIQES----AKQIEAKDNKITELLNDVERLKQ 1333
Cdd:PRK02224  646 ARIE-EAREDKERAEEYLEQVEEKLDELREErddlQAEIGAVENELEELEELRERREA 702
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-226 5.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 5.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    34 YDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTsdtagrnalhLAAKYGh 113
Cdd:PHA02876  341 YITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA----------LSQKIG- 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   114 alclqkllqyncptehadlqgrTALHDAAMADCP-SSIQLLCDHGASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGA 191
Cdd:PHA02876  410 ----------------------TALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGA 467

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 59850762   192 DVNSRDKQNRTALMLGCEYgcRDAVEVLIKNGADI 226
Cdd:PHA02876  468 DVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
68-121 5.44e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 5.44e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 59850762     68 GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLL 121
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 807-1047 6.08e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.61  E-value: 6.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  807 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 886
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------LEQELAALEAELAEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  887 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE 966
Cdd:COG4942   89 EKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  967 IKAQKKELDTIQEcikvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1046
Cdd:COG4942  169 LEAERAELEALLA----------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                 .
gi 59850762 1047 K 1047
Cdd:COG4942  239 A 239
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 150-252 2.22e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVD-GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISL 228
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100
                  ....*....|....*....|....*...
gi 59850762   229 LDALG----HDSSYYARigdNLDILTLL 252
Cdd:PHA02878  230 RDKCGntplHISVGYCK---DYDILKLL 254
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 888-1102 2.50e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  888 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 967
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  968 KAQKKE----LDTIQECIKVKY-APIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1040
Cdd:COG4942  100 EAQKEElaelLRALYRLGRQPPlALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762 1041 QKDLRDK----TVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
Cdd:COG4942  180 LAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK01156 PRK01156
chromosome segregation protein; Provisional
 779-1336 2.64e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.21  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   779 KLEMEKLLLEN--DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 856
Cdd:PRK01156  163 SLERNYDKLKDviDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALN 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   857 NQyvpvktheevkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936
Cdd:PRK01156  243 EL-----------SSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKK 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   937 QSMRKVQDSNAEILANYRKgQEEIVTLHAEIKAQKKELDTIQECI------KVKYAPIV-SFEECERKFKATEKELKDQL 1009
Cdd:PRK01156  312 QILSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQIlelegyEMDYNSYLkSIESLKKKIEEYSKNIERMS 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLK------DLSQKYTEvk 1083
Cdd:PRK01156  391 AFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgtTLGEEKSN-- 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1084 NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGtiENLKEelksmqrcYEKEQQTVTKLHQLLENQKNSS 1163
Cdd:PRK01156  469 HIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES--EEINK--------SINEYNKIESARADLEDIKIKI 538

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1164 VPLAE-HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVS-----KLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Cdd:PRK01156  539 NELKDkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISlidieTNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1238 TQISSLNEKLANLNRKYEEVCE-----EVLHAK----KKEISAKDEkellhfsIEQEIKDQKERCDKSLTTITELQRRIQ 1308
Cdd:PRK01156  619 KSIREIENEANNLNNKYNEIQEnkiliEKLRGKidnyKKQIAEIDS-------IIPDLKEITSRINDIEDNLKKSRKALD 691

                         570       580
                  ....*....|....*....|....*...
gi 59850762  1309 ESAKQIEAKDNKITELLNDVERLKQALN 1336
Cdd:PRK01156  692 DAKANRARLESTIEILRTRINELSDRIN 719
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 105-233 2.78e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  105 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 169
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  170 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 233
Cdd:cd22192   92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
PHA02798 PHA02798
ankyrin-like protein; Provisional
 150-248 4.73e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.99  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVDGRTPLV-----LATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLIK 221
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                          90       100
                  ....*....|....*....|....*...
gi 59850762   222 NGADISLLDALGHDS-SYYARIGDNLDI 248
Cdd:PHA02798  134 NGADTTLLDKDGFTMlQVYLQSNHHIDI 161
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 279-1219 4.75e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.59  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    279 HMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILldkvnglqLQLNEEVMVADDLESEREKLKSLLaaKE 356
Cdd:TIGR00606  221 EIRDQITSKEAQLESSReiVKSYENELDPLKNRLKEIEHNLSKI--------MKLDNEIKALKSRKKQMEKDNSEL--EL 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    357 KQHEESLRTIEALKNRFKYFESDHLGSGSHFS--------NRKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLR 424
Cdd:TIGR00606  291 KMEKVFQGTDEQLNDLYHNHQRTVREKERELVdcqrelekLNKERRLLNQEKTELlveqGRLQLQADRHQEHIRARDSLI 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    425 pLELSLPSQTSYSENE-ILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQ 503
Cdd:TIGR00606  371 -QSLATRLELDGFERGpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLG 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    504 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNH--RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMI-VEEFKRD 580
Cdd:TIGR00606  440 RTIELKKEILEKKQEELKFVIKELQQLEGSSDRilELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    581 EGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP----AEKFENMKSSLSNEVNEKAKKLVEMERE 656
Cdd:TIGR00606  520 LDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKE 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    657 HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIteltlknQTLQKEIEKVYLDNKLLKEQAHNL 736
Cdd:TIGR00606  600 LASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEI-------EKSSKQRAMLAGATAVYSQFITQL 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    737 TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIAL 816
Cdd:TIGR00606  673 TDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPEL 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    817 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVK--------MTLNDTLAKTNRELLDVKK 888
Cdd:TIGR00606  750 RNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiaqQAAKLQGSDLDRTVQQVNQ 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    889 KFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQdsnaeilanyrKGQEEIVTLHAEik 968
Cdd:TIGR00606  830 EKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTE-- 896

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    969 aqkkeldtIQECIKvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT 1048
Cdd:TIGR00606  897 --------VQSLIR-------EIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIE 961

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1049 VLIEKSheMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLveENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1128
Cdd:TIGR00606  962 NKIQDG--KDDYLKQKETELNTVNAQLEECEKHQEKINEDM--RLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEEL 1037

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1129 ENLKEELKSMQRCYEKeqQTVTKLHQLLENQKNSSVPLAEHLQikeAFEKEVGIIKASLREKeeESQNKMEEVSKLQSEV 1208
Cdd:TIGR00606 1038 KQHLKEMGQMQVLQMK--QEHQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVM 1110

                          970
                   ....*....|.
gi 59850762   1209 QNTKQALKKLE 1219
Cdd:TIGR00606 1111 RTTELVNKDLD 1121
Ank_2 pfam12796
Ankyrin repeats (3 copies);
171-252 5.39e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 5.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    171 LVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAdislLDALGHDSS--YYARIGDNLDI 248
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 59850762    249 LTLL 252
Cdd:pfam12796   77 VKLL 80
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
947-1398 5.98e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.92  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  947 AEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKvKYAPIVSFEECERKFKATEKELKdQLSEQTQKYSVSEEEVKKN 1026
Cdd:COG4717   84 EEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELA-ELPERLEELEERLEELREL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1027 KQENDKLKKEIFTLQKDLRDKtvLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL--VEENAKQTSEILAVQ 1104
Cdd:COG4717  162 EEELEELEAELAELQEELEEL--LEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELeeLEEELEQLENELEAA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1105 NLLQKQHVPLEQ---------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1175
Cdd:COG4717  240 ALEERLKEARLLlliaaallaLLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEE 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1176 fekEVGIIKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETREvvdlskYKATKSDLETQISSLnekLANLNRKYE 1255
Cdd:COG4717  320 ---ELEELLAALGLPPDLSP---EELLELLDRIEELQELLREAEELE------EELQLEELEQEIAAL---LAEAGVEDE 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1256 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKslTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335
Cdd:COG4717  385 EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEA--LDEEELEEELEELEEELEELEEELEELREELAELEAEL 462

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59850762 1336 NGLsqltytsgnptkRQSQLIDTLQHQVKSLEQQLADADRQHQeVIAIYRTHLLSAAQGHMDE 1398
Cdd:COG4717  463 EQL------------EEDGELAELLQELEELKAELRELAEEWA-ALKLALELLEEAREEYREE 512
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 897-1369 6.11e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    897 FVKIKDKNEILKRNLENTQNQIKAeyisLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT 976
Cdd:TIGR00618  367 IREISCQQHTLTQHIHTLQQQKTT----LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAEL 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    977 IQECIKVKY----APIVSFEECERKFKATEKELKD--QLSEQTQKYSVSEEEVKKNKQENDK-LKKEIFTLQKDLRDKTV 1049
Cdd:TIGR00618  443 CAAAITCTAqcekLEKIHLQESAQSLKEREQQLQTkeQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIDN 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1050 LIEKSHEMERALSRKT-------------DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1116
Cdd:TIGR00618  523 PGPLTRRMQRGEQTYAqletseedvyhqlTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEK 602

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1117 VEALKKSLNGTIENLKEELK----------SMQRCYEKEQQTVTKLHQLLENQKNSSVplAEHLQIKEAFEKEVGiikAS 1186
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQpeqdlqdvrlHLQQCSQELALKLTALHALQLTLTQERV--REHALSIRVLPKELL---AS 677

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1187 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLET------REVVDLSKYKAT-KSDLETQISSLNEKLANLNRKYEEVCE 1259
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTLLRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1260 E--VLHAKKKEISAKDEKELLHFS-IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLndVERLKQALN 1336
Cdd:TIGR00618  758 ArtEAHFNNNEEVTAALQTGAELShLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL--VQEEEQFLS 835

                          490       500       510
                   ....*....|....*....|....*....|...
gi 59850762   1337 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1369
Cdd:TIGR00618  836 RLEEKSATLGEITHQLLKYEECSKQLAQLTQEQ 868
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 950-1250 8.05e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.71  E-value: 8.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  950 LANYRKGQEEIVTLHAEIKAQKKELDTIQecikvkyapivsfeecerkfkATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1029
Cdd:COG1196  231 LLKLRELEAELEELEAELEELEAELEELE---------------------AELAELEAELEELRLELEELELELEEAQAE 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1030 NDKLKKEIFTLQKDlrdktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Cdd:COG1196  290 EYELLAELARLEQD-------IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1110 QhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiiKASLRE 1189
Cdd:COG1196  363 A---EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA----LAELEE 435

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1250
Cdd:COG1196  436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 485-1253 9.17e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.35  E-value: 9.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    485 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAasgnhrLTEELKDQLKDLKVKYEGASAEVGKLR 564
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL------LTLCTPCMPDTYHERKQVLEKELKHLR 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    565 NQIKQnEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSnevn 644
Cdd:TIGR00618  233 EALQQ-TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE-----------LRAQEAVLEETQERINRARKAAPLA---- 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    645 EKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQksgelgkkitelTLKNQTLQKEIE-KVY 723
Cdd:TIGR00618  297 AHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ------------TLHSQEIHIRDAhEVA 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    724 LDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
Cdd:TIGR00618  365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    804 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ------EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 877
Cdd:TIGR00618  445 AAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEqihlqeTRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPG 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    878 KTNRELLdvkkkfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 957
Cdd:TIGR00618  525 PLTRRMQ--------------RGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQ 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    958 EEIVTLHAEIKAQKKEldtiqecikvkyapivsfeecERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK---LK 1034
Cdd:TIGR00618  591 NITVRLQDLTEKLSEA---------------------EDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltaLH 649

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1035 KEIFTLQKDLRDKTVLIEKSHEMERALSRKtdelnKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
Cdd:TIGR00618  650 ALQLTLTQERVREHALSIRVLPKELLASRQ-----LALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1115 EQVEALKKSLNGTIENLKEELKSmqrcYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA--------FEKEVGIIKAS 1186
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKE----LMHQARTVLKARTEAHFNNNEEVTAALQTGAELShlaaeiqfFNRLREEDTHL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1187 LREKEEESQNKME--------EVSKLQSEVQNTKQALKKLETR---------EVVDLSKYKATKSDLETQISSLNEKLAN 1249
Cdd:TIGR00618  801 LKTLEAEIGQEIPsdedilnlQCETLVQEEEQFLSRLEEKSATlgeithqllKYEECSKQLAQLTQEQAKIIQLSDKLNG 880


                   ....
gi 59850762   1250 LNRK 1253
Cdd:TIGR00618  881 INQI 884
PHA03095 PHA03095
ankyrin-like protein; Provisional
 150-226 9.30e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 9.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVDGRTPLVLATQMS---RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR-DAVEVLIKNGAD 225
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGAD 109


                  .
gi 59850762   226 I 226
Cdd:PHA03095  110 V 110
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 997-1315 1.08e-05

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 49.83  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   997 KFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--KTVLiEKSHEMERALsrktDELNKQ 1071
Cdd:PRK04778   99 RFRKAKHEINEiesLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRElrKSLL-ANRFSFGPAL----DELEKQ 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1072 LKDLSQKYTEVKNVKEklvEENAKQTSEILAVQ----NLLQKQ--HVPlEQVEALKKSLNGTIENLKEELKSMQRC-YEK 1144
Cdd:PRK04778  174 LENLEEEFSQFVELTE---SGDYVEAREILDQLeeelAALEQImeEIP-ELLKELQTELPDQLQELKAGYRELVEEgYHL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1145 EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAfEKEVGIIKA------SLREKEEESQNKMEE-VSKLQSEVQNTKQALKK 1217
Cdd:PRK04778  250 DHLDIEKEIQDLKEQIDENLALLEELDLDEA-EEKNEEIQEridqlyDILEREVKARKYVEKnSDTLPDFLEHAKEQNKE 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1218 LETR-EVVDLSkYKATKSDLETQiSSLNEKLANLNRKYEEVCEEVlhaKKKEISakdekellhFSieqEIKDQKERCDKS 1296
Cdd:PRK04778  329 LKEEiDRVKQS-YTLNESELESV-RQLEKQLESLEKQYDEITERI---AEQEIA---------YS---ELQEELEEILKQ 391

                         330
                  ....*....|....*....
gi 59850762  1297 LTTITELQRRIQESAKQIE 1315
Cdd:PRK04778  392 LEEIEKEQEKLSEMLQGLR 410
COG5022 COG5022
Myosin heavy chain [General function prediction only];
811-1341 1.14e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.08  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  811 KEIIALKSNIVELKKQLSELKKKCGED-QEKIHALTSENTNLKKMMSNqyVPVKTHEEVKMTLNDTLAKtnreLLDVKKK 889
Cdd:COG5022  892 KSISSLKLVNLELESEIIELKKSLSSDlIENLEFKTELIARLKKLLNN--IDLEEGPSIEYVKLPELNK----LHEVESK 965

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  890 FEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS---MRKVQDSNAEILANYRKGQEEIVTLHAE 966
Cdd:COG5022  966 LKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEStkqLKELPVEVAELQSASKIISSESTELSIL 1045

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  967 IKAQK-------KELDTIQECIKVKYAPIVSFEEC------------ERKFKATEKELKDQ-----------LSEQTQKY 1016
Cdd:COG5022 1046 KPLQKlkgllllENNQLQARYKALKLRRENSLLDDkqlyqlestenlLKTINVKDLEVTNRnlvkpanvlqfIVAQMIKL 1125

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER----ALSRKTDELNKQLKDLSQKYT----EVKNVKEK 1088
Cdd:COG5022 1126 NLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpsppPFAALSEKRLYQSALYDEKSKlsssEVNDLKNE 1205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1089 LVEENAKQTSEIL---AVQNLLQKQHVPLEQVEALKKSLNG----------TIENLKEELKSMQRCYEKEQQTVTKLHQL 1155
Cdd:COG5022 1206 LIALFSKIFSGWPrgdKLKKLISEGWVPTEYSTSLKGFNNLnkkfdtpasmSNEKLLSLLNSIDNLLSSYKLEEEVLPAT 1285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1156 LENQ-KNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvVDLSKYKATKS 1234
Cdd:COG5022 1286 INSLlQYINVGLFNALRTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEELEELIQAVKVLQLLK-DDLNKLDELLD 1364

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1235 DLETQissLNEKLANLNRKYEevCEEVLHAKKKEISAKDEkellhfsieqeikdqKERCDKSLTTITELQRRIQESAKQI 1314
Cdd:COG5022 1365 ACYSL---NPAEIQNLKSRYD--PADKENNLPKEILKKIE---------------ALLIKQELQLSLEGKDETEVHLSEI 1424

                        570       580
                 ....*....|....*....|....*..
gi 59850762 1315 EAKDNKITELLNDVERLKQALNGLSQL 1341
Cdd:COG5022 1425 FSEEKSLISLDRNSIYKEEVLSSLSAL 1451
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1032-1283 1.41e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.54  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1032 KLKK-EIFTLqKDLRDKTVliEKSHEMERA--LSRKTDELNKQLKDLSQKYTEVKNVKEKL--------VEENAKQTSEI 1100
Cdd:PRK05771    5 RMKKvLIVTL-KSYKDEVL--EALHELGVVhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpklnPLREEKKKVSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1101 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQQTVTKLH------QLLENQKNSSVPLAEhlqIKE 1174
Cdd:PRK05771   82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----LEQEIERLEPWGnfdldlSLLLGFKYVSVFVGT---VPE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1175 AFEKEVGIIKaSLREKEEESQNKMEE-----VSKLQSEVQNTkqALKKLETREVV---------DLSKYKATKSDLETQI 1240
Cdd:PRK05771  155 DKLEELKLES-DVENVEYISTDKGYVyvvvvVLKELSDEVEE--ELKKLGFERLEleeegtpseLIREIKEELEEIEKER 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 59850762  1241 SSLNEKLANLNRKYEE---VCEEVL--HAKKKEISAKDEKELLHFSIE 1283
Cdd:PRK05771  232 ESLLEELKELAKKYLEellALYEYLeiELERAEALSKFLKTDKTFAIE 279
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1003-1381 1.67e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.51  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1003 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV 1082
Cdd:PRK01156  172 KDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1083 KNVKEKLVEENAKQTSEILAVQNL--LQKQHVPLEQVEALKK--------SLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
Cdd:PRK01156  252 NRYESEIKTAESDLSMELEKNNYYkeLEERHMKIINDPVYKNrnyindyfKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1153 HQL-------LENQKNSSVPLAEHLQIKEAFEKEVGIIKA--SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREv 1223
Cdd:PRK01156  332 SVLqkdyndyIKKKSRYDDLNNQILELEGYEMDYNSYLKSieSLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE- 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1224 vdLSKYKATKSDLETQISSLNEKLANLNRKYEE---------------VCEEVLHAKKKEISAKD--------EKELLHF 1280
Cdd:PRK01156  411 --LNEINVKLQDISSKVSSLNQRIRALRENLDElsrnmemlngqsvcpVCGTTLGEEKSNHIINHynekksrlEEKIREI 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1281 SIEQEIKDQKERCDKSLTTITELQ--RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT--------------YT 1344
Cdd:PRK01156  489 EIEVKDIDEKIVDLKKRKEYLESEeiNKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKnrykslkledldskRT 568

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 59850762  1345 SGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVI 1381
Cdd:PRK01156  569 SWLNALAVISLIDieTNRSRSNEIKKQLNDLESRLQEIE 607
COG5022 COG5022
Myosin heavy chain [General function prediction only];
945-1326 1.73e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.69  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFKATEKELKDQLSEQTQK-------- 1015
Cdd:COG5022  804 SLLGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIqKFGRSLKAKKRFSLLKKETIYLQSAQrvelaerq 883

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1016 ---YSVSEEEVKKNKQENDKLKKEIF----TLQKDLRDKT-VLIEKSHEMERALS------------RKTDELNK----- 1070
Cdd:COG5022  884 lqeLKIDVKSISSLKLVNLELESEIIelkkSLSSDLIENLeFKTELIARLKKLLNnidleegpsieyVKLPELNKlheve 963

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1071 -QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTV 1149
Cdd:COG5022  964 sKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQL----KELPVEVAELQSASKIISSES 1039

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1150 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQnkMEEVSKLQSEVQNTKQALKKLET---REVVDL 1226
Cdd:COG5022 1040 TELSILKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQ--LESTENLLKTINVKDLEVTNRNLvkpANVLQF 1117

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1227 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTI-TELQR 1305
Cdd:COG5022 1118 IVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKsKLSSS 1197

                        410       420
                 ....*....|....*....|.
gi 59850762 1306 RIQESAKQIEAKDNKITELLN 1326
Cdd:COG5022 1198 EVNDLKNELIALFSKIFSGWP 1218
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 77-204 2.00e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   77 SKGNLECLNAILI-HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-----YNCPTEHADLQGRTALHDAAMADCPSSI 150
Cdd:cd22192   26 KENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLV 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  151 QLLCDHGASVNAKDVD--------------GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 204
Cdd:cd22192  106 RELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 490-722 2.04e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  490 EQIKQLEDALKDVQKRMYESEGKVKQMQthflalkehltseaasgnhRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALK-------------------KEEKALLKQLAALERRIAALARRIRALEQELAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  570 NEMIVEEFKRDEGKLIEENKRLQKELSmcEMERekkgrkVTEMEGQAKELSAKLALSIPAEKFENMK---------SSLS 640
Cdd:COG4942   81 LEAELAELEKEIAELRAELEAQKEELA--ELLR------ALYRLGRQPPLALLLSPEDFLDAVRRLQylkylaparREQA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  641 NEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKpeEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Cdd:COG4942  153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA--ERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                 ..
gi 59850762  721 KV 722
Cdd:COG4942  231 RL 232
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
490-688 2.39e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  490 EQIKQLEDALKDVQKrmYEsegKVKQMQTHFLALKEHLTSEAAsgnHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
Cdd:COG4913  249 EQIELLEPIRELAER--YA---AARERLAELEYLRAALRLWFA---QRRLELLEAELEELRAELARLEAELERLEARLDA 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  570 NEMIVEEFKR----DEGKLIEenkRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA------------EKFE 633
Cdd:COG4913  321 LREELDELEAqirgNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalraeaaallEALE 397

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762  634 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR-------ELENVKAKLAQHVKPEEHE 688
Cdd:COG4913  398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDALAEALGLDEAE 459
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 489-801 2.40e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  489 DEQIKQLE-DALKDVQKRMYESEGKVKQMQTHFLALKEhLTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQI 567
Cdd:COG1196  199 ERQLEPLErQAEKAERYRELKEELKELEAELLLLKLRE-LEAELEELEAEL-EELEAELEELEAELAELEAELEELRLEL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  568 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALsipaekfenmkssLSNEVNEKA 647
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE-------------LEEELEELE 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  648 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 726
Cdd:COG1196  344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEElEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 59850762  727 KLLKEQAHNLTIEMKNHyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 801
Cdd:COG1196  424 EELEEALAELEEEEEEE---EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1059-1275 2.55e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1059 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQnllqkqhvplEQVEALKKSLNGTIENLKEELKSM 1138
Cdd:COG3883   26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQ----------AEIAEAEAEIEERREELGERARAL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1139 QRcyekEQQTVTKLHQLLENQKNSSVplaehlqikeafekevgIIKASLREKEEESQNK-MEEVSKLQSEVQNTKQALKK 1217
Cdd:COG3883   96 YR----SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADlLEELKADKAELEAKKAELEA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEK 1275
Cdd:COG3883  155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAA-EAQLAELEAELAAAEAA 211
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 538-831 2.63e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  538 LTEELKDQLKDLK-----------VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
Cdd:COG1196  194 ILGELERQLEPLErqaekaeryreLKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  607 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQH---- 681
Cdd:COG1196  274 LELEELELELEEAQAEEyELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAeeel 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  682 ----VKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHyvplkvsEDMKKSH 757
Cdd:COG1196  354 eeaeAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL-------EEELEEL 426

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762  758 DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLSELK 831
Cdd:COG1196  427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA---ALLEAALAELLEELAEAAARLLLLL 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1019-1253 2.97e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1019 SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1098
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1099 EILAVQNLLQKQHV---PLEQVEALKKSLNGtiENLKEELKSMQRcyekeqqtvtkLHQLLENQKNSSVPLAEHLQIKEA 1175
Cdd:COG4942   98 ELEAQKEELAELLRalyRLGRQPPLALLLSP--EDFLDAVRRLQY-----------LKYLAPARREQAEELRADLAELAA 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762 1176 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1253
Cdd:COG4942  165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 716-1359 3.39e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.89  E-value: 3.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    716 QKEIEKvyldNKLLKEQAHNLTIEMKNHYVPLKVSEDM---KKSHDAIID---DLNRKLLDVTQKYTEK--KLEMEKLLL 787
Cdd:TIGR01612 1506 AKAIEK----NKELFEQYKKDVTELLNKYSALAIKNKFaktKKDSEIIIKeikDAHKKFILEAEKSEQKikEIKKEKFRI 1581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKsnIVELKKQLSELKKKCGEDQEKIHALT--SENTNLKKMMSNqyvpVKTH 865
Cdd:TIGR01612 1582 EDDAAKNDKSNKAAIDIQLSLENFENKFLK--ISDIKKKINDCLKETESIEKKISSFSidSQDTELKENGDN----LNSL 1655

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    866 EEVKMTLNDTlaKTNREllDVKKKFEDINQEFVKIKDKNEILKRNLE-NTQNQIKAEYISlaeHEAKMSSLSQSmrkVQD 944
Cdd:TIGR01612 1656 QEFLESLKDQ--KKNIE--DKKKELDELDSEIEKIEIDVDQHKKNYEiGIIEKIKEIAIA---NKEEIESIKEL---IEP 1725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKD-QLSEQTQKYSVSEEEV 1023
Cdd:TIGR01612 1726 TIENLISSFNTNDLEGIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNtRINAQNEFLKIIEIEK 1805

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1024 KKNKQENDKLKKEIFTLQKDLRDKTvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKN-VKEKLVEENAKQTSEILA 1102
Cdd:TIGR01612 1806 KSKSYLDDIEAKEFDRIINHFKKKL------DHVNDKFTKEYSKINEGFDDISKSIENVKNsTDENLLFDILNKTKDAYA 1879

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1103 vqNLLQKQHVP--------LEQVEALKKSLNGTIEN------LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplae 1168
Cdd:TIGR01612 1880 --GIIGKKYYSykdeaekiFINISKLANSINIQIQNnsgidlFDNINIAILSSLDSEKEDTLKFIPSPEKEPEI------ 1951

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1169 HLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKqalkklETREVVDLSKYKATK--SDLETQISSLN 1244
Cdd:TIGR01612 1952 YTKIRDSYDTLLDIFKKSqdLHKKEQDTLNIIFENQQLYEKIQASN------ELKDTLSDLKYKKEKilNDVKLLLHKFD 2025

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1245 E--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
Cdd:TIGR01612 2026 ElnKLSCDSQNYDTILELSKQDKIKEKIDNYEKEKEKFGIDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKD 2105

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 59850762   1323 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
Cdd:TIGR01612 2106 NIIQSKKKLKELTEAFNTEIKIIEDKIIEKNDLIDKL 2142
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 748-1121 6.02e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 6.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   748 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 827
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   828 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 903
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   904 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 983
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   984 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1045
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1046 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1119
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 59850762  1120 LK 1121
Cdd:NF033838  445 EK 446
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 493-1378 6.35e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 6.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    493 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEvgkLRNQIKQNEM 572
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    573 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA-EKFENMKSSLSNEVnEKAKKLV 651
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAArNKAEKQRRDLGEEL-EALKTEL 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    652 EMEREHEKSLSEIRQlKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvylDNKLLKE 731
Cdd:pfam01576  309 EDTLDTTAAQQELRS-KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK---AKQALES 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    732 QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEK 811
Cdd:pfam01576  385 ENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSK 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    812 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFE 891
Cdd:pfam01576  462 DVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    892 DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIK 968
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    969 AqkkeldtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDL 1044
Cdd:pfam01576  615 A-----------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDD 675

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1045 RDKTVlieksHEME---RALSRKTDELNKQLKDLSQkytevknvkEKLVEENAKQTSEIlavqnllqkqhvpleQVEALK 1121
Cdd:pfam01576  676 VGKNV-----HELErskRALEQQVEEMKTQLEELED---------ELQATEDAKLRLEV---------------NMQALK 726

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1122 KSLNGTIENLKEELKsmqrcyEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV 1201
Cdd:pfam01576  727 AQFERDLQARDEQGE------EKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1202 SKLQSEVQNTKQALK--KLETREVVDLSKYKATKS-DLETQISSLNEKLANLNR-------KYEEVCEEVLHAKKKEISA 1271
Cdd:pfam01576  801 KKLQAQMKDLQRELEeaRASRDEILAQSKESEKKLkNLEAELLQLQEDLAASERarrqaqqERDELADEIASGASGKSAL 880

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1272 KDEKELLhfsiEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL--------SQLTY 1343
Cdd:pfam01576  881 QDEKRRL----EARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnkelkAKLQE 956

                          890       900       910
                   ....*....|....*....|....*....|....*
gi 59850762   1344 TSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQ 1378
Cdd:pfam01576  957 MEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQ 991
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 439-920 6.94e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.41  E-value: 6.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    439 NEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL-------EDALKDVQKRMYESEG 511
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLliqitekENKMKDLTFLLEESRD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    512 KVKQMQ----------THFLALKEHLTSE----------AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 571
Cdd:pfam05483  269 KANQLEektklqdenlKELIEKKDHLTKEledikmslqrSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    572 MIVEEFKRDEGKLIE----ENKRLQK---ELSMCEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKfenmkSSLSNE 642
Cdd:pfam05483  349 FVVTEFEATTCSLEEllrtEQQRLEKnedQLKIITMELQKKSSELEEMTKfkNNKEVELEELKKILAED-----EKLLDE 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    643 vNEKAKKLVEMEREHEKSLSEIRQLK-RELENVKAKLAQHVKPEEHeqvksrLEQKSGELGKKITELTLKNQTLQKEIEK 721
Cdd:pfam05483  424 -KKQFEKIAEELKGKEQELIFLLQAReKEIHDLEIQLTAIKTSEEH------YLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    722 VYLDNKLLKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 801
Cdd:pfam05483  497 LLLENKELTQEASDMTLELKKHQEDII---NCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    802 vfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEevkmtlnDTLAKTNR 881
Cdd:pfam05483  574 ---NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYE-------IKVNKLEL 643

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 59850762    882 ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 920
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKA 682
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
482-680 7.06e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  482 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEH----LTSEAASGNHRLTeELKDQLKDLKVKYEGAS 557
Cdd:COG3206  167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNglvdLSEEAKLLLQQLS-ELESQLAEARAELAEAE 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  558 AEVGKLRNQIKQNEMIVEEFKRDegkliEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaekfeNMKS 637
Cdd:COG3206  240 ARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA---------ALRA 305

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 59850762  638 SLSNEVnekAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ 680
Cdd:COG3206  306 QLQQEA---QRILASLEAELEALQAREASLQAQLAQLEARLAE 345
Ank_5 pfam13857
Ankyrin repeats (many copies);
53-108 7.24e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 7.24e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762     53 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLA 108
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 249-893 7.37e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 7.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILLDKVng 326
Cdd:TIGR02168  353 LESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNneIERLEARLERLEDRRERLQQEIEELLKKL-- 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQmymads 406
Cdd:TIGR02168  431 EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF------ 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    407 qctSPGIPAHMQSRSMLRPLELSLPSQTSYSENeiLKKELEA----------MRTFcESAKQDRLKLQNELAHKVAECkA 476
Cdd:TIGR02168  505 ---SEGVKALLKNQSGLSGILGVLSELISVDEG--YEAAIEAalggrlqavvVENL-NAAKKAIAFLKQNELGRVTFL-P 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    477 LALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVkqmqthflalkeHLTSEAASGNHRLTEELKDQLKDLKVKYEGA 556
Cdd:TIGR02168  578 LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKL------------RKALSYLLGGVLVVDDLDNALELAKKLRPGY 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    557 saevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKelsmcEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEKFENM 635
Cdd:TIGR02168  646 -------RIVTLDGDLVRPGGVITGGSAKTNSSILER-----RREIEELEEKIEELEEKIAELEKALAeLRKELEELEEE 713

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    636 KSSLSNEVNEKAKKLVEM-------EREHEKSLSEIRQLKRELENVKAKLA-QHVKPEEHEQVKSRLEQKSGELGKKITE 707
Cdd:TIGR02168  714 LEQLRKELEELSRQISALrkdlarlEAEVEQLEERIAQLSKELTELEAEIEeLEERLEEAEEELAEAEAEIEELEAQIEQ 793

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Cdd:TIGR02168  794 LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELES 873

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    788 ENDSLSKDVSRLETVFVPPEKH----EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY-VPV 862
Cdd:TIGR02168  874 ELEALLNERASLEEALALLRSEleelSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYsLTL 953

                          650       660       670
                   ....*....|....*....|....*....|.
gi 59850762    863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 893
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIKEL 984
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1183-1409 9.35e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1183 IKASLREKEEESQNKM----EEVSKLQSEVQNTKQALKKLETRE-VVDLSkykATKSDLETQISSLNEKLANLNRKYEEV 1257
Cdd:COG3206  162 LEQNLELRREEARKALefleEQLPELRKELEEAEAALEEFRQKNgLVDLS---EEAKLLLQQLSELESQLAEARAELAEA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1258 ceEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG 1337
Cdd:COG3206  239 --EARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILA 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762 1338 LSQLTYTSGNPTKRQ-SQLIDTLQHQVKSL---EQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQ 1409
Cdd:COG3206  317 SLEAELEALQAREASlQAQLAQLEARLAELpelEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVID 392
46 PHA02562
endonuclease subunit; Provisional
 489-699 9.74e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 568
Cdd:PHA02562  187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   569 QNEMIVEEFKRDE-----------------------GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKlal 625
Cdd:PHA02562  266 KIKSKIEQFQKVIkmyekggvcptctqqisegpdriTKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLEL--- 342

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59850762   626 sipAEKFENMKSSLSNEVNEKAKKLVEMER---EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG 699
Cdd:PHA02562  343 ---KNKISTNKQSLITLVDKAKKVKAAIEElqaEFVDNAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKDSG 416
Ank_5 pfam13857
Ankyrin repeats (many copies);
186-233 1.04e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 59850762    186 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALG 233
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 580-1291 1.07e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.97  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    580 DEGKLIEENKRLQKELSMCE-MEREKKGRKVTEMEGQAKELSaklalSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHE 658
Cdd:TIGR01612  694 DKAKLDDLKSKIDKEYDKIQnMETATVELHLSNIENKKNELL-----DIIVEIKKHIHGEINKDLNKILEDFKNKEKELS 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    659 KSLSEIRQLKRELENVKAKLAQhVKPEEHEQ--VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 736
Cdd:TIGR01612  769 NKINDYAKEKDELNKYKSKISE-IKNHYNDQinIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNK 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    737 TiemkNHYVPLK--VSEDMKKSHDAIIDDLNRKLLDVTQkytEKKLEMEKLLLENDSLSKDVSrletvfvppekheKEII 814
Cdd:TIGR01612  848 V----DKFINFEnnCKEKIDSEHEQFAELTNKIKAEISD---DKLNDYEKKFNDSKSLINEIN-------------KSIE 907

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    815 ALKSNIVELKKqLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND----TLAKTNRELLDVKKK- 889
Cdd:TIGR01612  908 EEYQNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDkfdnTLIDKINELDKAFKDa 986

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    890 ----FEDINQEFVK-IKDKNEILKRNLENTQnqikaeYISLAEHEAKMSSLSQsmrKVQDSNAEI----LANYRKGQEEI 960
Cdd:TIGR01612  987 slndYEAKNNELIKyFNDLKANLGKNKENML------YHQFDEKEKATNDIEQ---KIEDANKNIpnieIAIHTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    961 VTLHAEIKAQKKELDTiqECIKVKYAPIVSFEECERKFK---------------ATE-KELKDQLSEQTQK--YSVSEEE 1022
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNK--EILEEAEINITNFNEIKEKLKhynfddfgkeenikyADEiNKIKDDIKNLDQKidHHIKALE 1135

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1023 VKKNKQEN--DKLKKEIFTLQkDLRDKTVLIEKSHEMERALSRKTDELNKQlkdlSQKYTEVKNVKEKLVEENAKQTS-E 1099
Cdd:TIGR01612 1136 EIKKKSENyiDEIKAQINDLE-DVADKAISNDDPEEIEKKIENIVTKIDKK----KNIYDEIKKLLNEIAEIEKDKTSlE 1210

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1100 ILAVQNLLQKQHVP---LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE------------------- 1157
Cdd:TIGR01612 1211 EVKGINLSYGKNLGklfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDikaemetfnishdddkdhh 1290

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1158 -----NQKNSSVPLAEHLQIKEAFEKEVGI--IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDlsKYK 1230
Cdd:TIGR01612 1291 iiskkHDENISDIREKSLKIIEDFSEESDIndIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID--EVK 1368

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762   1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVlhaKKKEISAKDEKELLHFSIEQEIKDQKE 1291
Cdd:TIGR01612 1369 EYTKEIEENNKNIKDELDKSEKLIKKIKDDI---NLEECKSKIESTLDDKDIDECIKKIKE 1426
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 947-1409 1.60e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.50  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    947 AEILANYrKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERK--------FKATEKELKDQLSE--QTQKY 1016
Cdd:TIGR00618  166 KELLMNL-FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREALQQtqQSHAY 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEmERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1096
Cdd:TIGR00618  245 LTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQE-RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSR 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1097 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT-----VTKLHQLLENQKNSSVPLAEHLQ 1171
Cdd:TIGR00618  324 AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQKLQSLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1172 IKEAFEKEVGIIKASLR---------EKEEESQNKMEEVSKLQSEVQNTKQALKKLE-------TREVVDLSKYKATKSD 1235
Cdd:TIGR00618  404 ILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHlqesaqsLKEREQQLQTKEQIHL 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1236 LETQISSLNEKLANLNRKYE-EVCEEVLH--AKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1312
Cdd:TIGR00618  484 QETRKKAVVLARLLELQEEPcPLCGSCIHpnPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1313 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL---------QHQVKSLEQQLADADRQHQEVIAI 1383
Cdd:TIGR00618  564 QMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceqhallrKLQPEQDLQDVRLHLQQCSQELAL 643

                          490       500
                   ....*....|....*....|....*.
gi 59850762   1384 YRTHLLSAAQGHMDEDVQEALLQIIQ 1409
Cdd:TIGR00618  644 KLTALHALQLTLTQERVREHALSIRV 669
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 907-1158 1.63e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.30  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    907 LKRNLENtqnQIKAEYISLAEHEAKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTL--HAEIKAQKKELdtiqecikvk 984
Cdd:pfam18971  557 VRRNLEN---KLTAKGLSLQEANKLIKDFLSSNKEL----AGKALNFNKAVAEAKSTgnYDEVKKAQKDL---------- 619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    985 yapivsfEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendklKKEIFTL--QKDLRDKTVL--IEKSHEMERA 1060
Cdd:pfam18971  620 -------EKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALinKEANRDARAIayTQNLKGIKRE 687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1061 LSRKTDELNKQLKDLSQKYTEVKNVKEKlveENAKQTSEILAVQNLLQKQHVPLEQVEalkkslngTIENLKEELKSMQR 1140
Cdd:pfam18971  688 LSDKLEKISKDLKDFSKSFDEFKNGKNK---DFSKAEETLKALKGSVKDLGINPEWIS--------KVENLNAALNEFKN 756

                          250
                   ....*....|....*...
gi 59850762   1141 CYEKEQQTVTKLHQLLEN 1158
Cdd:pfam18971  757 GKNKDFSKVTQAKSDLEN 774
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 106-186 1.82e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   106 HLAAKyGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 185
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  .
gi 59850762   186 L 186
Cdd:PTZ00322  167 L 167
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 166-198 1.92e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 59850762    166 DGRTPLVLA-TQMSRPTICQLLIDRGADVNSRDK 198
Cdd:pfam00023    1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-153 1.93e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 59850762    101 GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 153
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 184-252 2.18e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762   184 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 252
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 826-1331 2.58e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   826 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyVPVKTHEEVkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNE 905
Cdd:PTZ00440  985 KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD--LIKKQHDDI-IELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSF 1061

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   906 ILKRNLENTQNQIKAEYISLAEHeaKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-------KKELDTIQ 978
Cdd:PTZ00440 1062 HFNIDIKKYKNPKIKEEIKLLEE--KVEAL---LKKIDENKNKLIEIKNKSHEHVVNADKEKNKQtehynkkKKSLEKIY 1136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   979 ECIKVKYAPIVSFEECERKFKATEK-----------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDlrdk 1047
Cdd:PTZ00440 1137 KQMEKTLKELENMNLEDITLNEVNEieieyerilidHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKNMSKERND---- 1212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1048 tvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKlvEENAKQTSEILAVQNLLqkqHVPLEQVealkKSLNGT 1127
Cdd:PTZ00440 1213 -------HLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEIKLQV---FSYLQQV----IKENNK 1276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1128 IENLKEELKSMqrcyeKEQQTVTKLHQLLENQKNSSVPLAEH-LQIKEAFEKEVGIIKASLR--EKEEESQNKM---EEV 1201
Cdd:PTZ00440 1277 MENALHEIKNM-----YEFLISIDSEKILKEILNSTKKAEEFsNDAKKELEKTDNLIKQVEAkiEQAKEHKNKIygsLED 1351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1202 SKLQSEVQNTKQALKKL-ETREVVD--LSKYKATKSDLETQISSLNEKLANLNrkyeevceevLHAKKKEISAKDEKEll 1278
Cdd:PTZ00440 1352 KQIDDEIKKIEQIKEEIsNKRKEINkyLSNIKSNKEKCDLHVRNASRGKDKID----------FLNKHEAIEPSNSKE-- 1419

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 59850762  1279 hFSIeQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1331
Cdd:PTZ00440 1420 -VNI-IKITDNINKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSIL 1470
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1211-1335 2.63e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.62  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1211 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEVCEEVLHAKKKEIsAKDEKELLHFSIEQEIKDQK 1290
Cdd:COG2433  386 IEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERL-EAEVEELEAELEEKDERI-ERLERELSEARSEERREIRK 463

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 59850762 1291 ERcdksltTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335
Cdd:COG2433  464 DR------EISRLDREIERLERELEEERERIEELKRKLERLKELW 502
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 990-1339 2.75e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.40  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEndklkkeifTLQKDLRDK-TVLIEKSHEMERALSRKTDEL 1068
Cdd:pfam05667  207 SLLERNAAELAAAQEWEEEWNSQGLASRLTPEEYRKRKRT---------KLLKRIAEQlRSAALAGTEATSGASRSAQDL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1069 NKQLKDLSQKYTEVKNV--------KEKLV--EENAKQTSEILAV----QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1134
Cdd:pfam05667  278 AELLSSFSGSSTTDTGLtkgsrfthTEKLQftNEAPAATSSPPTKveteEELQQQREEELEELQEQLEDLESSIQELEKE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1135 LKSMQrcyekeqQTVTKLHQLLENQKNSSVPLAEHLQIKEafeKEVGIIkaslrekeEESQNKMEevsKLQSEVQNTKQA 1214
Cdd:pfam05667  358 IKKLE-------SSIKQVEEELEELKEQNEELEKQYKVKK---KTLDLL--------PDAEENIA---KLQALVDASAQR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1215 LKKLEtrevvdlSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV--LHAKKKEISAK-DEKELLHfsieQEIKDQKE 1291
Cdd:pfam05667  417 LVELA-------GQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIkeLREKIKEVAEEaKQKEELY----KQLVAEYE 485

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 59850762   1292 RCDKSlTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1339
Cdd:pfam05667  486 RLPKD-VSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 136-260 2.87e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   136 TALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGAD----------------------- 192
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   193 VNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL--KTASENTN 260
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLleKGAYANVK 186
Ank_5 pfam13857
Ankyrin repeats (many copies);
120-174 3.13e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 3.13e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 59850762    120 LLQY-NCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLA 174
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-185 3.28e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   38 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLEcLNAILIHGV------DITTSDTAGRNALHLAAKY 111
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-AAVVLMEAApelvnePMTSDLYQGETALHIAVVN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  112 GHALCLQKLLQYNcptehADLQ-----------GRTAL-----HDAAMADCPSS---IQLLCDHGASVNAKDVDGRTPL- 171
Cdd:cd22192  100 QNLNLVRELIARG-----ADVVspratgtffrpGPKNLiyygeHPLSFAACVGNeeiVRLLIEHGADIRAQDSLGNTVLh 174

                        170
                 ....*....|....
gi 59850762  172 VLATQMSRPTICQL 185
Cdd:cd22192  175 ILVLQPNKTFACQM 188
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1070-1250 3.36e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1070 KQLKDLSQKYTE---VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQ 1146
Cdd:COG1579    7 RALLDLQELDSEldrLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1147 QTVTKLHQLlenqknssvplaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1226
Cdd:COG1579   83 GNVRNNKEY------------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKK 144

                        170       180
                 ....*....|....*....|....
gi 59850762 1227 SKYKATKSDLETQISSLNEKLANL 1250
Cdd:COG1579  145 AELDEELAELEAELEELEAEREEL 168
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
495-696 3.36e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.14  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  495 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE------ELKDQLKDLKVKYEGASAEVGKLRnQIK 568
Cdd:COG4717   47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAElqeeleELEEELEELEAELEELREELEKLE-KLL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  569 QNEMIVEEFKRDEGKLIEENKRLQkELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaEKFENMKSSLSNEVNEKAK 648
Cdd:COG4717  126 QLLPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELE-----ELLEQLSLATEEELQDLAE 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 59850762  649 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Cdd:COG4717  200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKE 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
489-666 3.58e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 568
Cdd:COG4913  616 EAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQLE 695

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  569 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAKLALSIPAEKFENMKSSLSNEV 643
Cdd:COG4913  696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARlelraLLEERFAAALGDAVERELRENLEERI 775

                        170       180
                 ....*....|....*....|...
gi 59850762  644 NEKAKKLVEMEREHEKSLSEIRQ 666
Cdd:COG4913  776 DALRARLNRAEEELERAMRAFNR 798
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 991-1354 3.70e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.35  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    991 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1070
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1071 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1151 KLHQLLENQKNSSVPLaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1230
Cdd:pfam02463  325 KAEKELKKEKEEIEEL-------EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1231 ATKSDLETQISSLNEklanlNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1310
Cdd:pfam02463  398 ELKSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSED 472

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 59850762   1311 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1354
Cdd:pfam02463  473 LLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALI 516
PHA02798 PHA02798
ankyrin-like protein; Provisional
 150-227 3.74e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.83  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVDGRTPLVlaTQMSRPTICQL-----LIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLIK 221
Cdd:PHA02798   92 VKILIENGADINKKNSDGETPLY--CLLSNGYINNLeillfMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLE 169


                  ....*.
gi 59850762   222 NGADIS 227
Cdd:PHA02798  170 KGVDIN 175
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 862-1372 4.11e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.17  E-value: 4.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    862 VKTHEEVKMTLNDTLAKTNRElldvKKKFEDINQEFVKIKDKNEILKRNLENTQNQikaeyislaeHEAKMSSLSQSMRK 941
Cdd:pfam01576  133 IKKLEEDILLLEDQNSKLSKE----RKLLEERISEFTSNLAEEEEKAKSLSKLKNK----------HEAMISDLEERLKK 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    942 VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELdtiqecikvkyapivsfEECERKFKATEKELKDQLSEQTQKYSVSEE 1021
Cdd:pfam01576  199 EEKGRQELEKAKRKLEGESTDLQEQIAELQAQI-----------------AELRAQLAKKEEELQAALARLEEETAQKNN 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1022 EVKKNKQendkLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----------SQKYTEVKNVKEKLV 1090
Cdd:pfam01576  262 ALKKIRE----LEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTldttaaqqelrSKREQEVTELKKALE 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1091 EENAKQTSEilaVQNLLQKQHVPLEQ--------------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH-QL 1155
Cdd:pfam01576  338 EETRSHEAQ---LQEMRQKHTQALEElteqleqakrnkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEgQL 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1156 LENQKNSSVPLAEHLQIKEAFEK---EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTkQALKKLETREvvdlskykat 1232
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKlqsELESVSSLLNEAEGKNIKLSKDVSSLESQLQDT-QELLQEETRQ---------- 483

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1233 KSDLETQISSLNEKLANLNRKYEEvceevlhakkkEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1312
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEE-----------EEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQR 552

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1313 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1372
Cdd:pfam01576  553 ELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAE 612
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1059-1320 4.13e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1059 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSM 1138
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1139 QRCYEKeqqtvtklhQLLENQKNSSVPLAEHLQIKEAFEkEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKkl 1218
Cdd:COG4942  103 KEELAE---------LLRALYRLGRQPPLALLLSPEDFL-DAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE-- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1219 etrevvdlskykATKSDLETQISSLNEKLANLNrkyeevceevlhakkkeiSAKDEKELLHFSIEQEIKDQKERCDKSLT 1298
Cdd:COG4942  171 ------------AERAELEALLAELEEERAALE------------------ALKAERQKLLARLEKELAELAAELAELQQ 220

                        250       260
                 ....*....|....*....|..
gi 59850762 1299 TITELQRRIQESAKQIEAKDNK 1320
Cdd:COG4942  221 EAEELEALIARLEAEAAAAAER 242
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-164 4.87e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 4.87e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 59850762    133 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 164
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1181-1412 4.92e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1181 GIIKasLREKEEESQNKMEEVS-------------------------------KLQSEVQNTKQALKKLETREV-VDLSK 1228
Cdd:COG1196  166 GISK--YKERKEEAERKLEATEenlerledilgelerqleplerqaekaeryrELKEELKELEAELLLLKLRELeAELEE 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1229 YKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEKELLHFS----IEQEIKDQKERCDKSLTTITELQ 1304
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEEL-RLELEELELELEEAQAEEYELLAelarLEQDIARLEERRRELEERLEELE 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1305 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQhQEVIAIY 1384
Cdd:COG1196  323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA-AAELAAQ 401

                        250       260
                 ....*....|....*....|....*...
gi 59850762 1385 RTHLLSAAQGHMDEdvQEALLQIIQMRQ 1412
Cdd:COG1196  402 LEELEEAEEALLER--LERLEEELEELE 427
PRK11281 PRK11281
mechanosensitive channel MscK;
761-1124 5.01e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.90  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   761 IDDLN-RKLLDVTQKYTEKKLEMEKLLLENdslskdvsrletvfvppekhekeIIALKSNIVELKKQLSELKKKCGEDQE 839
Cdd:PRK11281   45 LDALNkQKLLEAEDKLVQQDLEQTLALLDK-----------------------IDRQKEETEQLKQQLAQAPAKLRQAQA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   840 KIHALTSENTN-LKKMMSNQYVPvktheevkmTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneiLKRNLENTQNQI 918
Cdd:PRK11281  102 ELEALKDDNDEeTRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYNSQLVS-------LQTQPERAQAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   919 KAEYISLAEHEAKMSSLSQSMRKVQDSNAEILanyrkgQEEIVTLHAEIKAQKKEL---DTIQECIKVKYapivsfEECE 995
Cdd:PRK11281  166 YANSQRLQQIRNLLKGGKVGGKALRPSQRVLL------QAEQALLNAQNDLQRKSLegnTQLQDLLQKQR------DYLT 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   996 RKFKATEKELKD----------QLSEQTQKYSVSEEEVKKnKQENDKLKKEiftlqkdlrdktvlIEKSHEMERALSRKT 1065
Cdd:PRK11281  234 ARIQRLEHQLQLlqeainskrlTLSEKTVQEAQSQDEAAR-IQANPLVAQE--------------LEINLQLSQRLLKAT 298

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762  1066 DELNkqlkDLSQKYTEVKNVKEklveenakqtseilavqNLLQKQHVPLEQVEALKKSL 1124
Cdd:PRK11281  299 EKLN----TLTQQNLRVKNWLD-----------------RLTQSERNIKEQISVLKGSL 336
46 PHA02562
endonuclease subunit; Provisional
 608-833 5.24e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   608 KVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEMEREhekslsEIRQLKRELENVKAKLAQHVK 683
Cdd:PHA02562  175 KIRELNQQIQTLDMKIDHIQQQiktyNKNIEEQRKKNGENIARKQNKYDELVE------EAKTIKAEIEELTDELLNLVM 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   684 PEEheqvksRLEQKSGELGKKITELTLKNQTLQKEIeKVYLDNKL-----------------LKEQAHNLTI---EMKNH 743
Cdd:PHA02562  249 DIE------DPSAALNKLNTAAAKIKSKIEQFQKVI-KMYEKGGVcptctqqisegpdritkIKDKLKELQHsleKLDTA 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   744 YVPLKVSEDMkkshdaiIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALKSNIVEL 823
Cdd:PHA02562  322 IDELEEIMDE-------FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFV---DNAEELAKLQDELDKI 391

                         250
                  ....*....|
gi 59850762   824 KKQLSELKKK 833
Cdd:PHA02562  392 VKTKSELVKE 401
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 577-841 5.59e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   577 FKRDEGKLIEEnkrLQKE-----LSMCEMEREKKGRKVTEMEGQAKELSAKL------ALSIPAEKFENMKSSLSNEVNE 645
Cdd:PRK05771   14 LKSYKDEVLEA---LHELgvvhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpkLNPLREEKKKVSVKSLEELIKD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   646 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhVKP-------EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 718
Cdd:PRK05771   91 VEEELEKIEKEIKELEEEISELENEIKELEQEIER-LEPwgnfdldLSLLLGFKYVSVFVGTVPEDKLEELKLESDVENV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   719 IEKVYLDNKL------LKEQAHNLTIEMKNH-YVPLKVSE------------DMKKSHDAIIDDLNRKLLDVTQKYTEKK 779
Cdd:PRK05771  170 EYISTDKGYVyvvvvvLKELSDEVEEELKKLgFERLELEEegtpselireikEELEEIEKERESLLEELKELAKKYLEEL 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762   780 LEMEKLLL----ENDSLSKDVSRLETVFVP---PEKHEKEIIALKSNIVELKKQLSELKKKcgEDQEKI 841
Cdd:PRK05771  250 LALYEYLEieleRAEALSKFLKTDKTFAIEgwvPEDRVKKLKELIDKATGGSAYVEFVEPD--EEEEEV 316
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 995-1161 5.59e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--------- 1065
Cdd:PRK05771   74 EEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvp 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1066 -DELNKQLKDLSQKYTE-VKNVKEKLV------EENAKQTSEILAvQNLLQKQHVP--------LEQVEALKKSLNGTIE 1129
Cdd:PRK05771  154 eDKLEELKLESDVENVEyISTDKGYVYvvvvvlKELSDEVEEELK-KLGFERLELEeegtpselIREIKEELEEIEKERE 232

                         170       180       190
                  ....*....|....*....|....*....|..
gi 59850762  1130 NLKEELKSMQRCYEKEQQTVtklHQLLENQKN 1161
Cdd:PRK05771  233 SLLEELKELAKKYLEELLAL---YEYLEIELE 261
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1050-1338 5.86e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1050 LIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLvEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGT 1127
Cdd:PRK03918  140 ILESDESREKVVRQILglDDYENAYKNLGEVIKEIKRRIERL-EKFIKRTENI---EELIKEKEKELEEVLREINEISSE 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1128 IENLKEELKSMqrcyEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1207
Cdd:PRK03918  216 LPELREELEKL----EKEVKELEELKEEIEELEKE----------LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1208 VQNTKQ---------ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEevLHAKKKEIS---AKDEK 1275
Cdd:PRK03918  282 VKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE--LKKKLKELEkrlEELEE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762  1276 ELLHFSIEQEIKDQKERCDKSLTTIT---------ELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL 1338
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLTGLTpeklekeleELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 999-1214 5.91e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  999 KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRdktvliekshEMERALSRKTDELNKQLKDLSQK 1078
Cdd:COG3883   29 QAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEERREELGERARALYRS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1079 YTEVkNVKEKLVeeNAKQTSEIL----AVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTVTKLHQ 1154
Cdd:COG3883   99 GGSV-SYLDVLL--GSESFSDFLdrlsALSKIADADADLLEELKADKAEL----EAKKAELEAKLAELEALKAELEAAKA 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1155 LLENQKnssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1214
Cdd:COG3883  172 ELEAQQ------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1128-1339 7.28e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 7.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1128 IENLKEELKSMQ-RCYEKEQQTVTKLHQLLENQKNssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206
Cdd:PRK05771   33 IEDLKEELSNERlRKLRSLLTKLSEALDKLRSYLP-----KLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1207 EVQNTKQALKKLEtREVVDLSKYKATKSDLETQISSLN----------EKLANLNRKYEEVCEEVLHAKK---------- 1266
Cdd:PRK05771  108 EISELENEIKELE-QEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvpeDKLEELKLESDVENVEYISTDKgyvyvvvvvl 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1267 KEISAKDEKELLHFS-IEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKITE--------LLNDVERLKQA 1334
Cdd:PRK05771  187 KELSDEVEEELKKLGfERLELEEEGtpsELIREIKEELEEIEKERESLLEELKELAKKYLEellalyeyLEIELERAEAL 266


                  ....*
gi 59850762  1335 LNGLS 1339
Cdd:PRK05771  267 SKFLK 271
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 527-736 7.31e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 7.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  527 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
Cdd:COG4942   10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  607 RKVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEM----EREHEKSLSEIRQLKRELENVKAKL 678
Cdd:COG4942   90 KEIAELRAELEAQKEELAELLRAlyrlGRQPPLALLLSPEDFLDAVRRLQYlkylAPARREQAEELRADLAELAALRAEL 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762  679 AQhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 736
Cdd:COG4942  170 EA--ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
PTZ00121 PTZ00121
MAEBL; Provisional
 928-1317 7.97e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 7.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   928 HEAKMSSLSQ--SMRKVQDSNAEILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYApiVSFEECERKFKAT 1001
Cdd:PTZ00121 1056 HEGKAEAKAHvgQDEGLKPSYKDFDFDAKEDNRADEATEEAFGkaeeAKKTETGKAEEARKAEEA--KKKAEDARKAEEA 1133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1002 EKELKDQLSEQTQKySVSEEEVKKNKQENDKLKKEIFTLQKDLRdKTVLIEKSHEMERALS-RKTDELNKqlKDLSQKYT 1080
Cdd:PTZ00121 1134 RKAEDARKAEEARK-AEDAKRVEIARKAEDARKAEEARKAEDAK-KAEAARKAEEVRKAEElRKAEDARK--AEAARKAE 1209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1081 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP--LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1158
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1159 QKNSSVPLAEHLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1236
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1237 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1316
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449


                  .
gi 59850762  1317 K 1317
Cdd:PTZ00121 1450 K 1450
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-98 8.33e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 8.33e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762     38 LMKAAERGDVEKVTSILAKKGVNpgkLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSD 98
Cdd:pfam12796   34 LHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
155-204 8.63e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 8.63e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 59850762    155 DHG-ASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 204
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-139 9.81e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 59850762     92 VDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALH 139
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1028-1313 9.97e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 43.61  E-value: 9.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1028 QENDKLKKEIFTLQKDLRDKTVLIEKS-----------------HEMERALsRKTDELNKQLKDLSQKYTEVKNVKEKLV 1090
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGKALNFNKAvaeakstgnydevkkaqKDLEKSL-RKREHLEKEVEKKLESKSGNKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1091 EENAkQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKeqqtvtklhqlLENQKNSSVPL 1166
Cdd:pfam18971  652 QANS-QKDEIFALINKEANRDARaiayTQNLKGIKRELSDKLEKISKDLKDFSKSFDE-----------FKNGKNKDFSK 719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1167 AEH-LQIKEAFEKEVGIikaslrekeeesqnKMEEVSKlqseVQNTKQALKKLETREVVDLSKYKATKSDLETQISS--L 1243
Cdd:pfam18971  720 AEEtLKALKGSVKDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviI 781

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59850762   1244 NEKLANlnrKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQ 1313
Cdd:pfam18971  782 NQKVTD---KVDNLNQAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1192-1336 1.01e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1192 EESQNKMEEVSKLQSEVQNTKQALKKLEtREVVDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKK 1267
Cdd:COG1579    3 PEDLRALLDLQELDSELDRLEHRLKELP-AELAELEDelaaLEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 59850762 1268 EISAKDEKELLhfSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1336
Cdd:COG1579   82 LGNVRNNKEYE--ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148
PRK12704 PRK12704
phosphodiesterase; Provisional
 1120-1292 1.07e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1120 LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhQLLENQKnssvplaEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKE-ALLEAKE-------EIHKLRNEFEKELRERRNELQKLEKRLLQKEE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1200 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL---ANLNRkyEEVCEEVLHAKKKEisAKDEKE 1276
Cdd:PRK12704   97 NLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELeriSGLTA--EEAKEILLEKVEEE--ARHEAA 172

                         170
                  ....*....|....*.
gi 59850762  1277 LLHFSIEQEIKDQKER 1292
Cdd:PRK12704  173 VLIKEIEEEAKEEADK 188
PHA02946 PHA02946
ankyin-like protein; Provisional
 150-227 1.08e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.12  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   150 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLIKNGADIS 227
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN 134
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1184-1379 1.17e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1184 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevVDLSKYKATKSDLETQISSLNEKLAnlnRKYEEVCEEVLH 1263
Cdd:COG3883   22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQ----AELEALQAEIDKLQAEIAEAEAEIE---ERREELGERARA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1264 AKKKE---------ISAKDEKELLH--FSIEQEIKDQKERcdksLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1332
Cdd:COG3883   95 LYRSGgsvsyldvlLGSESFSDFLDrlSALSKIADADADL----LEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 59850762 1333 QALNGLsqltytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1379
Cdd:COG3883  171 AELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
PLN02939 PLN02939
transferase, transferring glycosyl groups
 251-603 1.23e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   251 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 327
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   328 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 387
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   388 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 455
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   456 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 535
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59850762   536 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1225-1382 1.30e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1225 DLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLhakkkeisakdekellhfSIEQEIKDQKERcdkslttITELQ 1304
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYN------------------ELQAELEALQAE-------IDKLQ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1305 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyTSGNP-------------TKRQSQLIDTLQHQVKSLEQQLA 1371
Cdd:COG3883   72 AEIAEAEAEIEERREELGERARALYRSGGSVSYLDVLL-GSESFsdfldrlsalskiADADADLLEELKADKAELEAKKA 150

                        170
                 ....*....|.
gi 59850762 1372 DADRQHQEVIA 1382
Cdd:COG3883  151 ELEAKLAELEA 161
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 456-1069 1.41e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 43.42  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    456 AKQDRLKLQNELAHKVAECKAL------------ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 523
Cdd:TIGR00618  251 AQEEQLKKQQLLKQLRARIEELraqeavleetqeRINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKR 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    524 KEHLTSEAASGNHRLTEEL-----------KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 592
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTlhsqeihirdaHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQA 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    593 KELSMCEMEREKKGRKV---TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
Cdd:TIGR00618  411 TIDTRTSAFRDLQGQLAhakKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKA 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    670 ELENVKAKLAQHVKP----EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYV 745
Cdd:TIGR00618  491 VVLARLLELQEEPCPlcgsCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQ 570

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    746 PLKVSEDMKKSHDAIIDDLnRKLLDVTQKYTEKKLEMEKLLLEndslskdVSRLETVFVPPEKHEKEIIALKSNIVE--- 822
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNL-QNITVRLQDLTEKLSEAEDMLAC-------EQHALLRKLQPEQDLQDVRLHLQQCSQela 642

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    823 -LKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND--TLAKTNRELLDVKKKFEDINQEFVK 899
Cdd:TIGR00618  643 lKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWkeMLAQCQTLLRELETHIEEYDREFNE 722

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    900 IKDKNEILKRNLeNTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEivTLHAEIKAQKKELDTIQE 979
Cdd:TIGR00618  723 IENASSSLGSDL-AAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS--HLAAEIQFFNRLREEDTH 799

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    980 CIKVKYAPIvsfeECERKFKATEKELKDQLSEQtqkysvSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER 1059
Cdd:TIGR00618  800 LLKTLEAEI----GQEIPSDEDILNLQCETLVQ------EEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQA 869

                          650
                   ....*....|
gi 59850762   1060 ALSRKTDELN 1069
Cdd:TIGR00618  870 KIIQLSDKLN 879
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-84 1.47e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 59850762     34 YDDRLMKAAERGDVEkVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECL 84
Cdd:pfam13637    1 ELTALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
998-1292 2.11e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  998 FKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKdlrdktvlIEKSHEME---RALSRKTDELNKQL 1072
Cdd:COG4913  606 FDNRAKlaALEAELAELEEELAEAEERLEALEAELDALQERREALQR--------LAEYSWDEidvASAEREIAELEAEL 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1073 KDLSQKYTEVKNVKEKLVEenakqtseilavqnlLQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTkl 1152
Cdd:COG4913  678 ERLDASSDDLAALEEQLEE---------------LEAE---LEELEEELDELKGEIGRLEKELEQAEE----ELDELQ-- 733

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762 1153 HQLLENQKNSSVPLAEHLQikEAFEkevgiikaslREKEEESQNKMEEvsKLQSEVQNTKQALKKLETReVVDL-----S 1227
Cdd:COG4913  734 DRLEAAEDLARLELRALLE--ERFA----------AALGDAVERELRE--NLEERIDALRARLNRAEEE-LERAmrafnR 798

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762 1228 KYKATKSDLETQISSLNEKLAnlnrKYEEVCEEVLHAKKKEI------SAKDEKELLHFSIEQEIKDQKER 1292
Cdd:COG4913  799 EWPAETADLDADLESLPEYLA----LLDRLEEDGLPEYEERFkellneNSIEFVADLLSKLRRAIREIKER 865
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
486-719 2.37e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   486 EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQThflalkehltseaasgnhrlTEELKDQLKDLKVKYEGASAEVGKLRN 565
Cdd:PRK02224  471 EEDRERVEELEAELEDLEEEVEEVEERLERAED--------------------LVEAEDRIERLEERREDLEELIAERRE 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   566 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLS----- 640
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI------ESLERIRTLLAaiada 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   641 ----NEVNEKAKKLVEMEREHEKSLSEIRQLKRELEnvkAKLaQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 716
Cdd:PRK02224  605 edeiERLREKREALAELNDERRERLAEKRERKRELE---AEF-DEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQ 680


                  ...
gi 59850762   717 KEI 719
Cdd:PRK02224  681 AEI 683
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 200-227 2.51e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 2.51e-03
                           10        20
                   ....*....|....*....|....*...
gi 59850762    200 NRTALMLGCEYGCRDAVEVLIKNGADIS 227
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PRK12704 PRK12704
phosphodiesterase; Provisional
 995-1145 2.75e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   995 ERKFKATEKELKDQLSE-QTQKYSVSEEEVKKNKQENDKLK-----------KEIFTLQKDLRDKTVLIEKSHEmerALS 1062
Cdd:PRK12704   30 EAKIKEAEEEAKRILEEaKKEAEAIKKEALLEAKEEIHKLRnefekelrerrNELQKLEKRLLQKEENLDRKLE---LLE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqhvpleqvEALKKSLNGTIENLKEELKSMQRCY 1142
Cdd:PRK12704  107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE--------EAKEILLEKVEEEARHEAAVLIKEI 178


                  ...
gi 59850762  1143 EKE 1145
Cdd:PRK12704  179 EEE 181
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1050-1192 2.93e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.12  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKqtseilavqnLLQKQHVPLEQ-VEALKKSLNGTI 1128
Cdd:PRK00409  521 LIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDK----------LLEEAEKEAQQaIKEAKKEADEII 590

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762  1129 ENLkeelksmqRCYEKEQQTVTKLHQLLENQKNssvpLAEHLQIKEAFEKEVGIIKASLREKEE 1192
Cdd:PRK00409  591 KEL--------RQLQKGGYASVKAHELIEARKR----LNKANEKKEKKKKKQKEKQEELKVGDE 642
Ank_4 pfam13637
Ankyrin repeats (many copies);
167-220 3.01e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 3.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 59850762    167 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLI 220
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 540-685 3.19e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF----KRDEGKLieENKRLQKELSMCEMEREKKGRKVTEMEGQ 615
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVeariKKYEEQL--GNVRNNKEYEALQKEIESLKRRISDLEDE 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  616 AKELSAKLalsipaEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 685
Cdd:COG1579  112 ILELMERI------EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPE 175
PRK12704 PRK12704
phosphodiesterase; Provisional
 965-1100 3.38e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   965 AEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDL 1044
Cdd:PRK12704   51 AEAIKKEALLEAKEEIHKLR-------NEFEKELRERRNELQKLEKRLLQK----EENLDRKLELLEKREEELEKKEKEL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59850762  1045 RDKTVLIEKsheMERALSRKTDELNKQLKDLSQKYTE------VKNVKEKLVEENAKQTSEI 1100
Cdd:PRK12704  120 EQKQQELEK---KEEELEELIEEQLQELERISGLTAEeakeilLEKVEEEARHEAAVLIKEI 178
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 30-265 3.94e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 3.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762     30 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 103
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    104 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 179
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    180 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 244
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 59850762    245 nlDILTLLKTASENTNKGREL 265
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
PHA02798 PHA02798
ankyrin-like protein; Provisional
 50-261 4.12e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.36  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    50 VTSILAKKGVNPGKLDVEGRSVFHVVTSKG---NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA-------LCLQK 119
Cdd:PHA02798   91 IVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidieiikLLLEK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   120 LLQYNcptEHADLQGRTALH-------DAAMADCpssIQLLCDHGASVNAKDVDGRTPLVlatqmsrPTICQLLIDRGA- 191
Cdd:PHA02798  171 GVDIN---THNNKEKYDTLHcyfkyniDRIDADI---LKLFVDNGFIINKENKSHKKKFM-------EYLNSLLYDNKRf 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   192 ------------DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHdssyyarigdnldilTLLKTASENT 259
Cdd:PHA02798  238 kknildfifsyiDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGN---------------TCLFTAFENE 302


                  ..
gi 59850762   260 NK 261
Cdd:PHA02798  303 SK 304
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 437-734 4.19e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   437 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 514
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   515 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 594
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   595 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 655
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   656 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 726
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 59850762   727 KLLKEQAH 734
Cdd:NF033838  396 KKAEEEAK 403
mukB PRK04863
chromosome partition protein MukB;
1026-1393 4.59e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1026 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYtevknvkeklveenakqtseilavqn 1105
Cdd:PRK04863  277 HANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDY-------------------------- 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1106 llqkqhvpleqvealkkslngtiENLKEELKSMQ---RCYEKEQQTVTKLHQLLENqknssvpLAEHLQIKEafekEVGI 1182
Cdd:PRK04863  331 -----------------------QAASDHLNLVQtalRQQEKIERYQADLEELEER-------LEEQNEVVE----EADE 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1183 IKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1256
Cdd:PRK04863  377 QQEENEARAEAAE---EEVDELKSQLADYQQALDVQQTRAiqyqqaVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1257 VCEEVLHAKKKeisakdekellhFSIEQEIKDQKERCDKSLTTIT-------------ELQRRIQES---AKQIEAKDNK 1320
Cdd:PRK04863  454 ATEELLSLEQK------------LSVAQAAHSQFEQAYQLVRKIAgevsrseawdvarELLRRLREQrhlAEQLQQLRMR 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1321 ITEL------LNDVERLKQALNGLSQLTYTS----GNPTKRQSQLIDTLQHQVKSLEQQLADAdRQHQEVIAIYRTHLLS 1390
Cdd:PRK04863  522 LSELeqrlrqQQRAERLLAEFCKRLGKNLDDedelEQLQEELEARLESLSESVSEARERRMAL-RQQLEQLQARIQRLAA 600


                  ...
gi 59850762  1391 AAQ 1393
Cdd:PRK04863  601 RAP 603
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 437-679 4.80e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKV 513
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEleeELAELEEELEELEEELEELEEEL 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  514 KQMQTHFLALKEHLTS--EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 591
Cdd:COG1196  347 EEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  592 QKELsmcemerekkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Cdd:COG1196  427 EEAL--------------------AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486


                 ....*...
gi 59850762  672 ENVKAKLA 679
Cdd:COG1196  487 AEAAARLL 494
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 871-1333 4.94e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 41.35  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL---ENTQNQIKAEYISL-AEHEAKMSSLSQSMRKVQDSn 946
Cdd:pfam10174  293 QLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLtakEQRAAILQTEVDALrLRLEEKESFLNKKTKQLQDL- 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    947 aeilanyrkgQEEIVTLHAEIKAQKKELDtiqecikVKyapivsfeecERKFKATEKE---LKDQLSEQTQKYSVSEEEV 1023
Cdd:pfam10174  372 ----------TEEKSTLAGEIRDLKDMLD-------VK----------ERKINVLQKKienLQEQLRDKDKQLAGLKERV 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEK-SHEMERALSRKTDELNKQLKDLsqkytevKNVKEKLVeenakqtseilA 1102
Cdd:pfam10174  425 KSLQTDSSNTDTALTTLEEALSEKERIIERlKEQREREDRERLEELESLKKEN-------KDLKEKVS-----------A 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1103 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhqllENQKNSSVPLAEHLQIKEAFEKEVgi 1182
Cdd:pfam10174  487 LQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKL----ENQLKKAHNAEEAVRTNPEINDRI-- 560

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1183 ikaslREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEvcEEVL 1262
Cdd:pfam10174  561 -----RLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQE--MKKK 633

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59850762   1263 HAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQ 1333
Cdd:pfam10174  634 GAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNL--RAERRKQ 702
PRK11281 PRK11281
mechanosensitive channel MscK;
1001-1414 5.62e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1001 TEKELKDQLseqtqkysvseEEVKKNKQENDKLKkeifTLQKDLRDKTVLIEKSHEMERalsrKTDELNKQLKDLSQKYT 1080
Cdd:PRK11281   37 TEADVQAQL-----------DALNKQKLLEAEDK----LVQQDLEQTLALLDKIDRQKE----ETEQLKQQLAQAPAKLR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1081 EVKNVKEKLVEENAKQTSEILAVQNL--LQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-------K 1151
Cdd:PRK11281   98 QAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYansqrlqQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1152 LHQLLENQKNSSVPLAEHLQIKEAFEKevgiikASLREKEEESQNKMEEVSKLQsevqntkqalkkletrevvDLskYKA 1231
Cdd:PRK11281  175 IRNLLKGGKVGGKALRPSQRVLLQAEQ------ALLNAQNDLQRKSLEGNTQLQ-------------------DL--LQK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1232 TKSDLETQISSLNEKLANLnrkyeevcEEVLHAKKKEISAKDEKEllhfsieQEIKDQKERCDKSLTTITELQRRIQESA 1311
Cdd:PRK11281  228 QRDYLTARIQRLEHQLQLL--------QEAINSKRLTLSEKTVQE-------AQSQDEAARIQANPLVAQELEINLQLSQ 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1312 KQIEAKDnKITELLNDVERLKQALNGLSQltytsgnpTKR---------------------QSQLIDTLQhQVKSLEQQL 1370
Cdd:PRK11281  293 RLLKATE-KLNTLTQQNLRVKNWLDRLTQ--------SERnikeqisvlkgslllsrilyqQQQALPSAD-LIEGLADRI 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 59850762  1371 ADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1414
Cdd:PRK11281  363 ADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 116-204 6.50e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  116 CLQKLLqyNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNA---------KDVD-----GRTPLVLATQMSRPT 181
Cdd:cd22194  125 ILDRFI--NAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpKYKHegfyfGETPLALAACTNQPE 202

                         90       100
                 ....*....|....*....|....
gi 59850762  182 ICQLLIDRGAD-VNSRDKQNRTAL 204
Cdd:cd22194  203 IVQLLMEKESTdITSQDSRGNTVL 226
PRK01156 PRK01156
chromosome segregation protein; Provisional
 907-1374 6.91e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.04  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   907 LKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYA 986
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSIT---LKEIERLSIEYNNAMDDYNNLKSALN-ELSSLEDMKNRYESEIKTAES 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   987 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS---- 1062
Cdd:PRK01156  264 DLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNdyik 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1063 --RKTDELNKQLKDLSQ---KYT----EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1133
Cdd:PRK01156  344 kkSRYDDLNNQILELEGyemDYNsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISS 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1134 ELKSMQ---RCYEKEQQTVTKLHQLLENQKNSSVpLAEHLqikeAFEKEVGIIKASLREKE--EESQNKME-EVSKLQSE 1207
Cdd:PRK01156  424 KVSSLNqriRALRENLDELSRNMEMLNGQSVCPV-CGTTL----GEEKSNHIINHYNEKKSrlEEKIREIEiEVKDIDEK 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1208 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEISAKDEKELLHFS--- 1281
Cdd:PRK01156  499 IVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELkdkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAvis 578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  1282 -------------IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgNP 1348
Cdd:PRK01156  579 lidietnrsrsneIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKI----DN 654

                         490       500
                  ....*....|....*....|....*.
gi 59850762  1349 TKRQSQLIDTLQHQVKSLEQQLADAD 1374
Cdd:PRK01156  655 YKKQIAEIDSIIPDLKEITSRINDIE 680
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 808-1368 7.34e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 7.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMmsnqyVPVKTHEEVKMTLNDTLAKTNRelLDVK 887
Cdd:TIGR01612  576 HLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIKKA-----IDLKKIIENNNAYIDELAKISP--YQVP 648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    888 KKFEDINQEFVKIKDK-NEILKRNLENTQNQ----IKAEYISLAEHEAKMSSLSQSMRKVQD--SNAEI------LANYR 954
Cdd:TIGR01612  649 EHLKNKDKIYSTIKSElSKIYEDDIDALYNElssiVKENAIDNTEDKAKLDDLKSKIDKEYDkiQNMETatvelhLSNIE 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762    955 KGQEEIVTLHAEIKAQ-----KKELDTIQECIKVKYAPIVS-------FEECERKFKATEKELKDQLSEQTQKYSVSEEE 1022
Cdd:TIGR01612  729 NKKNELLDIIVEIKKHihgeiNKDLNKILEDFKNKEKELSNkindyakEKDELNKYKSKISEIKNHYNDQINIDNIKDED 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1023 VKKNKQENDKLKKEIfTLQKDLRDKTV------------LIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEKL 1089
Cdd:TIGR01612  809 AKQNYDKSKEYIKTI-SIKEDEIFKIInemkfmkddflnKVDKFINFENNCKEKIDSEHEQFAELTNKIkAEISDDKLND 887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1090 VEENAKQT-SEILAVQNLLQKQHvplEQVEALKKsLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV---- 1164
Cdd:TIGR01612  888 YEKKFNDSkSLINEINKSIEEEY---QNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLieks 963

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1165 --PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlsKYKATkSDLETQISS 1242
Cdd:TIGR01612  964 ykDKFDNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDE-----KEKAT-NDIEQKIED 1037

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1243 LNEKLANLnrkyeevcEEVLHAKKKEISAKDEKELLHfSIEQEIKDQKERCDKSLTTITELQRRIQ-----ESAKQIEAK 1317
Cdd:TIGR01612 1038 ANKNIPNI--------EIAIHTSIYNIIDEIEKEIGK-NIELLNKEILEEAEINITNFNEIKEKLKhynfdDFGKEENIK 1108

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 59850762   1318 -DNKITELLNDVERLKQALN-GLSQLTYTSgnptKRQSQLIDTLQHQVKSLEQ 1368
Cdd:TIGR01612 1109 yADEINKIKDDIKNLDQKIDhHIKALEEIK----KKSENYIDEIKAQINDLED 1157
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 290-721 7.77e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 7.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  290 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 369
Cdd:COG1196  396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  370 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 449
Cdd:COG1196  476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  450 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 524
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  525 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 604
Cdd:COG1196  629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  605 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 678
Cdd:COG1196  709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 59850762  679 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 721
Cdd:COG1196  787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
466-844 7.96e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.79  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtseaasgnhrltEELKDQ 545
Cdd:PRK02224  255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARR------------EELEDR 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 625
Cdd:PRK02224  323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   626 SipAEKFENMkSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-----KLAQHVKPEEHEQVKSRLEQKSGE 700
Cdd:PRK02224  403 A--PVDLGNA-EDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpECGQPVEGSPHVETIEEDRERVEE 479

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   701 LGKKITELTLKNQTLQKEIEKVyldnkllkeqahnltiemknhyvplkvsEDMKKSHDAiIDDLNRKLLDVTQKYTEKKL 780
Cdd:PRK02224  480 LEAELEDLEEEVEEVEERLERA----------------------------EDLVEAEDR-IERLEERREDLEELIAERRE 530

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59850762   781 EMEKLLLENDSLSKDVSRLETvfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL 844
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEA---EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESL 591
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 166-194 8.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 8.41e-03
                           10        20
                   ....*....|....*....|....*....
gi 59850762    166 DGRTPLVLATQMSRPTICQLLIDRGADVN 194
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1047-1363 8.68e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 40.32  E-value: 8.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1047 KTVLIEKSHE-------MERALSrKTDELNKQLKDL--SQKYTEVK-NVKEKLVE-ENAKQTSEILAVQNLLQKQHVplE 1115
Cdd:pfam07902   63 APVVVEGSGEstglfksLEEMLS-QLKELNLELTDTknSNLWSKIKlNNNGMLREyHNDTIKTEIVESAEGIATRIS--E 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1116 QVEALKKSLNGTIENLKEELKSMQR-CYEKEQQTVTKLHQLLENQKNSsvplaehlqikeafekevgiikaslrekeees 1194
Cdd:pfam07902  140 DTDKKLALINETISGIRREYQDADRqLSSSYQAGIEGLKATMASDKIG-------------------------------- 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1195 qnkmeevskLQSEVQNTKQALKKLETREVVDLS-KYKATKSDletQISSLNEKLANLNRKYEEVCEEVLHAKKKEISA-K 1272
Cdd:pfam07902  188 ---------LQAEIQASAQGLSQRYDNEIRKLSaKITTTSSG---TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQ 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762   1273 DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAkdnkitellndverLKQALNGL-SQLTYTSGNPTKR 1351
Cdd:pfam07902  256 STQQSTAYQISQEISNREGAVSRVQQDLDSYQRRLQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESR 321

                          330
                   ....*....|..
gi 59850762   1352 QSQLIDTLQHQV 1363
Cdd:pfam07902  322 ITQLAGLIEQKV 333
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 454-701 9.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  454 ESAKQDRLKLQNELAHKVAECKALALECERVK---EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtse 530
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLkqlAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL--- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  531 aasgnHRLTEELKDQLKDLkVKYEGASAEVGKLR----NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSmcemerekkg 606
Cdd:COG4942  100 -----EAQKEELAELLRAL-YRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELA---------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59850762  607 RKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE---LENVKAKLAQHVK 683
Cdd:COG4942  164 ALRAELEAERAELEALLA------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEaeeLEALIARLEAEAA 237

                        250
                 ....*....|....*...
gi 59850762  684 PEEHEQVKSRLEQKSGEL 701
Cdd:COG4942  238 AAAERTPAAGFAALKGKL 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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