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Conserved domains on  [gi|8922301|ref|NP_060504|]
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WD repeat-containing protein 70 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-498 4.64e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 4.64e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKV 333
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN- 411
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKc 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  412 -KPLFSASGlptmfPMTDCCFSPDDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGT 490
Cdd:cd00200 212 lGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*...
gi 8922301  491 GNGLAKVY 498
Cdd:cd00200 281 ADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-498 4.64e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 4.64e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKV 333
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN- 411
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKc 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  412 -KPLFSASGlptmfPMTDCCFSPDDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGT 490
Cdd:cd00200 212 lGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*...
gi 8922301  491 GNGLAKVY 498
Cdd:cd00200 281 ADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
177-441 6.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 6.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFagmdASFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRTLTG---HTgaVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVmecikgdqyivdMANTKGHTAMLHTGSWHPkiKGEFM-TCSNDATVRTWEVENPKkqksvfKPRTMQGKKV 333
Cdd:COG2319 230 LWDLATGKL------------LRTLTGHSGSVRSVAFSP--DGRLLaSGSADGTVRLWDLATGE------LLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHykQAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQfNKP 413
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLAT-GEL 364

                       250       260
                ....*....|....*....|....*...
gi 8922301  414 LFSASGLPTmfPMTDCCFSPDDKLIVTG 441
Cdd:COG2319 365 LRTLTGHTG--AVTSVAFSPDGRTLASG 390
PTZ00420 PTZ00420
coronin; Provisional
 280-418 8.04e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.42  E-value: 8.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301   280 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRTWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLIAAACQNGSIQ 357
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8922301   358 IWD-RNLTVHPKFHykqAHDSGTDTSCV---TFSYDGNVLASRGGDDS----LKLWDIRQFNKPLFSAS 418
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-210 6.24e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 8922301     177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 210
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-210 3.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 8922301    177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 210
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-498 4.64e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 4.64e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKV 333
Cdd:cd00200  77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN- 411
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKc 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  412 -KPLFSASGlptmfPMTDCCFSPDDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGT 490
Cdd:cd00200 212 lGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*...
gi 8922301  491 GNGLAKVY 498
Cdd:cd00200 281 ADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
177-441 6.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 6.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFagmdASFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL----ATGKLLRTLTG---HTgaVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVmecikgdqyivdMANTKGHTAMLHTGSWHPkiKGEFM-TCSNDATVRTWEVENPKkqksvfKPRTMQGKKV 333
Cdd:COG2319 230 LWDLATGKL------------LRTLTGHSGSVRSVAFSP--DGRLLaSGSADGTVRLWDLATGE------LLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHykQAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQfNKP 413
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLAT-GEL 364

                       250       260
                ....*....|....*....|....*...
gi 8922301  414 LFSASGLPTmfPMTDCCFSPDDKLIVTG 441
Cdd:COG2319 365 LRTLTGHTG--AVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
177-498 7.22e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 7.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFagmdASFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTG---HSgaVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDRDGFEVmecikgdqyivdMANTKGHTAMLHTGSWHPkiKGEFM-TCSNDATVRTWEVENPKkqksvfKPRTMQGKKV 333
Cdd:COG2319 188 LWDLATGKL------------LRTLTGHTGAVRSVAFSP--DGKLLaSGSADGTVRLWDLATGK------LLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  334 IPTTCTYSRDGNLIAAACQNGSIQIWDRNltvHPKFHYKQAHDSGTDTScVTFSYDGNVLASRGGDDSLKLWDIRQfNKP 413
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDGTVRLWDLAT-GKL 322

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  414 LFSASGLPTMFpmTDCCFSPDDKLIVTGTSiqrgcgSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNG 493
Cdd:COG2319 323 LRTLTGHTGAV--RSVAFSPDGKTLASGSD------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*
gi 8922301  494 LAKVY 498
Cdd:COG2319 395 TVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-406 5.38e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 5.38e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdasfkAFRSLQPCECHQ--IKSLQYSNTGDMILVVSGSSQAK 254
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTdwVNSVAFSPDGTFVASSSQDGTIK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  255 VIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPKiKGEFMTCSNDATVRTWEVENPKKQKsvfkprTMQGKKVI 334
Cdd:cd00200 161 LWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHENG 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8922301  335 PTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFhykQAHDSGTdtSCVTFSYDGNVLASRGGDDSLKLWD 406
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---SGHTNSV--TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
177-408 1.95e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.95e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMdasfKAFRSLQPCEcHQIKSLQYSNTGDMILVVSGSSQAKVI 256
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHS-GSVRSVAFSPDGRLLASGSADGTVRLW 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  257 DRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIP 335
Cdd:COG2319 274 DLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLATGKL------LRTLTGHTGAV 333

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8922301  336 TTCTYSRDGNLIAAACQNGSIQIWDrnLTVHPKFHYKQAHDSGTdtSCVTFSYDGNVLASRGGDDSLKLWDIR 408
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWD--LATGELLRTLTGHTGAV--TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
281-498 4.54e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 4.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  281 GHTAMLHTGSWHPKIKGeFMTCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD 360
Cdd:COG2319  76 GHTAAVLSVAFSPDGRL-LASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  361 -------RNLTVHPKfhykqahdsgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQfNKPLFSASGLPTMFpmTDCCFSP 433
Cdd:COG2319 149 latgkllRTLTGHSG-----------AVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAV--RSVAFSP 214

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8922301  434 DDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 498
Cdd:COG2319 215 DGKLLASGS------ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 326-505 1.66e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 1.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  326 RTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD-------RNLTVHPKF-HYKQAHDSGT------------------ 379
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDletgellRTLKGHTGPvRDVAASADGTylasgssdktirlwdlet 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  380 ------------DTSCVTFSYDGNVLASRGGDDSLKLWDIRQFnKPLFSASGLPTmfPMTDCCFSPDDKLIVTgtsiqrG 447
Cdd:cd00200  83 gecvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTD--WVNSVAFSPDGTFVAS------S 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 8922301  448 CGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVyYDPNKSQ 505
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL-WDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
177-315 2.85e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 2.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcECHQIKSLQYSNTGDMILVVSGSSQAKVI 256
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301  257 DRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVEN 315
Cdd:COG2319 358 DLATGELL------------RTLTGHTGAVTSVAFSPD--GRTLaSGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 280-418 8.04e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.42  E-value: 8.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301   280 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRTWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLIAAACQNGSIQ 357
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8922301   358 IWD-RNLTVHPKFHykqAHDSGTDTSCV---TFSYDGNVLASRGGDDS----LKLWDIRQFNKPLFSAS 418
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-210 6.24e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 8922301     177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 210
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-210 3.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 8922301    177 TLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 210
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 280-459 5.12e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 5.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301   280 KGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENpKKQKSVFKPRTMQGkkvipTTCTYSRDGNLIAAACQNGSIQIW 359
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSDQI-----TSLEWNLDGSLLCTTSKDKKLNII 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922301   360 D-RNLTVhpkFHYKQAHDSGTDTSCVtFSYDGNVLASRGGDDS----LKLWDIRQFNKPL-------FSASGLPTmfpmt 427
Cdd:PTZ00421 196 DpRDGTI---VSSVEAHASAKSQRCL-WAKRKDLIITLGCSKSqqrqIMLWDTRKMASPYstvdldqSSALFIPF----- 266

                        170       180       190
                 ....*....|....*....|....*....|..
gi 8922301   428 dccFSPDDKLIVTGTSiqrgcGSGKLVFFERR 459
Cdd:PTZ00421 267 ---FDEDTNLLYIGSK-----GEGNIRCFELM 290
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 326-360 5.89e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 8922301     326 RTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD 360
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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