OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 39725952 200 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 253
Cdd:cd16164   1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

Protein of unknown function (DUF745); This family consists of several uncharacterized Drosophila melanogaster proteins of unknown function.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 39725952    29 VEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQ 79
Cdd:pfam05335  61 VEQLEQELREAEAVVQEESASLQQSQANANAAQRAAQQAQQQLEALTAALK 111

OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 39725952 200 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 253
Cdd:cd16164   1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 39725952   203 SQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 253
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 39725952    435 TIGREKDmEHTLRIPEVGVSKFHAEIYFDHDLqSYVLVDQGSQNGTIVNGKQI 487
Cdd:smart00240   2 TIGRSSE-DCDIQLDGPSISRRHAVIVYDGGG-RFYLIDLGSTNGTFVNGKRI 52

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 39725952   620 SNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLG 661
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39725952  22 LAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNE 84
Cdd:COG4942  43 LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 39725952 200 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 253
Cdd:cd16164   1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 39725952   203 SQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 253
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 411 RVIVIRSPvlQIGSLFIITAvNPATIGREKDMEhtLRIPEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTIVNGKQILQp 490
Cdd:cd00060   1 RLIVLDGD--GGGREFPLTK-GVVTIGRSPDCD--IVLDDPSVSRRHARIEVDGG--GVYLEDLGSTNGTFVNGKRITP- 72

                        90       100
                ....*....|....*....|....*
gi 39725952 491 ktkcdPYVLEHGDEVKIGETVLSFH 515
Cdd:cd00060  73 -----PVPLQDGDVIRLGDTTFRFE 92

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39725952   435 TIGREKDmeHTLRIPEVGVSKFHAEIYFDhDLQSYVLVDQGSQNGTIVNGKQILQpktkcDPYVLEHGDEVKI 507
Cdd:pfam00498   2 TIGRSPD--CDIVLDDPSVSRRHAEIRYD-GGGRFYLEDLGSTNGTFVNGQRLGP-----EPVRLKDGDVIRL 66

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 412 VIVIRSPVLQIGSLFIITAvNPATIGRekDMEHTLRIPEVGVSKFHAEIYFDHDLQSyvLVDQGSQNGTIVNGKQIlqpk 491
Cdd:cd22682   1 ALLMIIGPPGVGKQFPITE-STIVIGR--SVESQVQIDDDSVSRYHAKLAVNPSAVS--IIDLGSTNGTIVNGKKI---- 71

                        90       100
                ....*....|....*....|....*
gi 39725952 492 TKCDPYVLEHGDEVKIGETVLSFHI 516
Cdd:cd22682  72 PKLASCDLQNGDQIKIGNTIFKFHE 96

OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins; RBM5 is a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor; it specifically binds poly(G) RNA. RBM10, a paralog of RBM5, may play an important role in mRNA generation, processing, and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. Both RBM5 and RBM10, contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 39725952 207 FSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRY 250
Cdd:cd16162   8 YQYDETSGYYYDPTTGLYYDPNSQYFYNSQTQQYLYWDQTKKTY 51

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 435 TIGREKDMehTLRIPEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTIVNGKQILQPKtkcdpyvLEHGDEVKIGETVLSF 514
Cdd:cd22698  24 TIGRSSNN--DIRLNDHSVSRHHARIVRQGD--KCNLTDLGSTNGTFLNGIRVGTHE-------LKHGDRIQLGETIFRF 92

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 411 RVIVIRSPVlQIGSLFIITAvNPATIGRekDMEHTLRIPEVGVSKFHAEIYFDHDLQSYvLVDQGSQNGTIVNGKQILQP 490
Cdd:cd22673   2 KLVVIKKDG-TDGSRFPLTK-KSCTFGR--DLSCDIRIQLPGVSREHCRIEVDENGKAY-LENLSTTNPTLVNGKAIEKS 76

                        90       100
                ....*....|....*....|....*
gi 39725952 491 KTkcdpyvLEHGDEVKIGETVLSFH 515
Cdd:cd22673  77 AE------LKDGDVITIGGRSFRFE 95

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 412 VIVIRSPVLqiGSLFIITAvNPATIGREKdmEHTLRIPEVGVSKFHAEiyFDHDLQSYVLVDQGSQNGTIVNGKQIlqpk 491
Cdd:cd22684   4 LVVRRGPNA--GARFLLDQ-DVTTAGRHP--ESDIFLDDVTVSRRHAE--FRRAEGGFVVRDVGSLNGTYVNRERI---- 72

                        90       100
                ....*....|....*....|....
gi 39725952 492 tkcDPYVLEHGDEVKIGETVLSFH 515
Cdd:cd22684  73 ---DSAVLRNGDEVQIGKFRLVFF 93

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 428 ITAVNPATIGREKDMEhtLRIPEVGVSKFHAEIYFDHDLqsYVLVDQGSQNGTIVNGKQIlqpktKCDPYVLEHGDEVKI 507
Cdd:cd22683  17 ITNRNVTTIGRSRSCD--LVLSDPSISRFHAELRLEQNG--INVIDNNSANGTFINGKRI-----KGKTYILKNGDIIVF 87

                ....*..
gi 39725952 508 GETVLSF 514
Cdd:cd22683  88 GKCSFLI 94

OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins; RBM6, also called lung cancer antigen NY-LU-12, or protein G16, or RNA-binding protein DEF-3, has been predicted to be a nuclear factor based on its nuclear localization signal. It shows high sequence similarity to RNA-binding protein 5 (RBM5 or LUCA15 or NY-REN-9). Both specifically binds poly(G) RNA. RBM6 contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain. In contrast to RBM5, RBM6 has an additional unique domain, the POZ (poxvirus and zinc finger) domain, which may be involved in protein-protein interactions and inhibit binding of target sequences by zinc fingers.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 39725952 186 EGSSLAESLRAAAEaavsqTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYY 242
Cdd:cd16163   1 EGSGPAPTYRSDPD-----SGYIYDPETGYYYDPVTGLYYDPATGEYVDPDTGTLPY 52

OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins; RBM10, also called G patch domain-containing protein 9, or RNA-binding protein S1-1 (S1-1), is a paralogue of putative tumor suppressor RNA-binding protein 5 (RBM5 or LUCA15 or H37). It may play an important role in mRNA generation, processing and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. RBM10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 39725952 207 FSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRY 250
Cdd:cd16167   9 YQYDETSGYYYDPQTGLYYDPNSQYYYNAQTQQYLYWDGERRTY 52

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 436 IGREkdmEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQpktkcDPYV-LEHGDEVKIGETVLSF 514
Cdd:cd22704  21 VGRE---DCDLILQSRSVDKQHAVITYDQIDNEFKIKDLGSLNGTFVNDSRIPE-----QTYItLKLGDSIRFGYDTNVY 92

                ....*...
gi 39725952 515 HIHPGSDT 522
Cdd:cd22704  93 RFEQLSLT 100

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952 433 PATIGRE------KDMEHT---LRIPEVgVSKFHAEIYFDHDLQSYVLVDQGSqNGTIVNGkqilQPKTKCDPYV-LEHG 502
Cdd:cd22701  18 EVVLGRNsknsssTAADSVdidLGPSKK-ISRRHARIFYDFTTQCFELSVLGR-NGVKVDG----ILVKPGSPPVpLRSG 91

                        90
                ....*....|..
gi 39725952 503 DEVKIGETVLSF 514
Cdd:cd22701  92 SLIQIGGVLFYF 103

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 39725952 433 PATIGREKDMEHTLRIPEVgvSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQIlQPKtkcDPYVLEHGDEVKIG 508
Cdd:cd22691  30 ILVVGRHPDCDIVLDHPSI--SRFHLEIRIIPSRRKITLTDLSSVHGTWVNGQRI-EPG---VPVELEEGDTVRLG 99

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39725952   435 TIGREKDMEHTLRipEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTIVNGKQILQPKTkcdpyVLEHGDEVKIGETVLSF 514
Cdd:pfam16697  20 RIGSDPDCDIVLS--DKEVSRVHLKLEVDDE--GWRLDDLGSGNGTLVNGQRVTELGI-----ALRPGDRIELGQTEFCL 90

OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins; RBM5 is a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor; it specifically binds poly(G) RNA. RBM10, a paralog of RBM5, may play an important role in mRNA generation, processing, and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. Both RBM5 and RBM10, contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 39725952 205 TGFSYDENTGLYFDHSTGFYYDSENQ--LYYDPSTGIY 240
Cdd:cd16162  14 SGYYYDPTTGLYYDPNSQYFYNSQTQqyLYWDQTKKTY 51

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 39725952 435 TIGREKDMEhtLRIPEVG-VSKFHAEIYFDHDLQSYvLVDQgSQNGTIVNGKQILQPKTkcdpYVLEHGDEVKI 507
Cdd:cd22672  24 TIGRAKDCD--LSFPGNKlVSGDHCKIIRDEKGQVW-LEDT-STNGTLVNKVKVVKGQK----VELKHGDVIYL 89

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39725952 435 TIGREKDMEHTLRIPEVgvSKFHAEIYFDHDLQS--YVLVDQGSQNGTIVNGkQILQPKTKcdpYVLEHGDEVKIGETV 511
Cdd:cd22689  48 TFGRHPACDYHLGNSRL--SNKHFQILLGESDPSdgNVLLNDISSNGTWLNG-QRLEKNSN---QLLSQGDEITIGVGV 120

OCRE domain found in Zinc-finger and OCRE domain-containing Protein 1 (ZOP1) and similar proteins found in plant; ZOP1 is a novel plant-specific nucleic acid-binding protein required for both RNA-directed DNA methylation (RdDM) and pre-mRNA splicing. It promotes RNA polymerase IV (Pol IV)-dependent siRNA accumulation, DNA methylation, and transcriptional silencing. As a pre-mRNA splicing factor, ZOP1 associates with several typical splicing proteins as well as with RNA polymerase II (RNAP II and Pol II). It also shows both RdDM-dependent and -independent roles in transcriptional silencing. ZOP1 contains an N-terminal C2H2-type ZnF domain and an OCtamer REpeat (OCRE) domain that is usually related to RNA processing.

                        10        20        30
                ....*....|....*....|....*....|
gi 39725952 209 YDENTGLYFDHSTGFYYDSENQLYYDPSTG 238
Cdd:cd16165  10 LDSKSGYYYNAATRYYYDPKTGMYYSDETG 39

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 39725952   620 SNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLG 661
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 39725952 435 TIGREkdmEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQI 487
Cdd:cd22700  19 TIGRE---GCDLVLQSPGVEEQHAVIEYSEQENCFVLQDLNTAQGTYVNDCRI 68

Protein of unknown function (DUF745); This family consists of several uncharacterized Drosophila melanogaster proteins of unknown function.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 39725952    29 VEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQ 79
Cdd:pfam05335  61 VEQLEQELREAEAVVQEESASLQQSQANANAAQRAAQQAQQQLEALTAALK 111

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39725952  22 LAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNE 84
Cdd:COG4942  43 LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins; SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 39725952 454 SKFHAEIYFDHDlqSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIG 508
Cdd:cd22679  50 SRNHALLWYDDG--KFYLQDTKSSNGTFVNNQRLSKGSEESEPRELHSGDIVQFG 102

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 39725952 435 TIGREKDM-EHTLRIPEVgvSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQiLQPKTkcdPYVLEHGDEVKIG 508
Cdd:cd22674  30 LFGRNSDVcDFVLDHPSC--SRVHAALVYHKHLNRVFLIDLGSTHGTFVGGIR-LEPHK---PQQLPIDSTLRFG 98