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Conserved domains on  [gi|21361720|ref|NP_060749|]
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transmembrane protein 19 [Homo sapiens]

Protein Classification

DUF92 domain-containing protein( domain architecture ID 10487781)

DUF92 domain-containing protein similar to vertebrate transmembrane protein 19 (TMEM19) and Arabidopsis thaliana protein PGR (plasma membrane glucose-responsive regulator), which is involved in the glucose-triggered developmental leaf growth process

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 59-322 7.83e-84

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


:

Pssm-ID: 460391  Cd Length: 237  Bit Score: 253.19  E-value: 7.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720    59 VVPVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFS--FFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKEGGQRNWVQV 136
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   137 FCNGAVPTELALLYMiengpgeipvdFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKsSPRLITTWEKVPVGTNG 216
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   217 GVTVVGLVSSLLGGTFVGIAYFLTQLifvndldisapqwpIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPT 296
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIVEGPG 214

                         250       260
                  ....*....|....*....|....*.
gi 21361720   297 nkaRHIAGKPILDNNAVNLFSSVLIA 322
Cdd:pfam01940 215 ---RKISGWDWLDNNAVNFLSTLIGA 237
 
Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 59-322 7.83e-84

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


Pssm-ID: 460391  Cd Length: 237  Bit Score: 253.19  E-value: 7.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720    59 VVPVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFS--FFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKEGGQRNWVQV 136
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   137 FCNGAVPTELALLYMiengpgeipvdFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKsSPRLITTWEKVPVGTNG 216
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   217 GVTVVGLVSSLLGGTFVGIAYFLTQLifvndldisapqwpIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPT 296
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIVEGPG 214

                         250       260
                  ....*....|....*....|....*.
gi 21361720   297 nkaRHIAGKPILDNNAVNLFSSVLIA 322
Cdd:pfam01940 215 ---RKISGWDWLDNNAVNFLSTLIGA 237
COG1836 COG1836
Cytidylyltransferase family enzyme [General function prediction only];
49-324 1.09e-55

Cytidylyltransferase family enzyme [General function prediction only];


Pssm-ID: 441441  Cd Length: 243  Bit Score: 181.53  E-value: 1.09e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720  49 ISPWRWLFSVVVPVLIVSNGLKKKSLDHSGALGGLVVGFIL-TIANFSFFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKE 127
Cdd:COG1836   2 VLLNPLLLALALSLLLGYLAYRKKLLTLSGALAAVLLGTLIiGLGGWGWFLLLLLFFILGSLLTKYGYKRKEALGIAEEK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720 128 GGQRNWVQVFCNGAVPTELALLYMiengpgeipvdFSKQYSASWMcLSLLAALACSAGDTWASEVGpVLSKSSPRLITTW 207
Cdd:COG1836  82 GGARGAGNVLANGGVALLAALLYA-----------ATPDDSPLFL-LAFAGSLATALADTWASEIG-VLSGKRPRLITTL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720 208 EKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLTQLIfvndldisaPQWPIIAFGGLAGLLGSIVDSYLGATMQytgldes 287
Cdd:COG1836 149 KPVPPGTSGGVSLLGTLAGLLGALLIALLAWLLGLI---------DSLLGLLIVVLAGFLGTLVDSLLGATLQ------- 212

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21361720 288 tgmvvnsptnkarhiAGKPILDNNAVNLFSSVLIALL 324
Cdd:COG1836 213 ---------------NKYGWLTNDGVNFLATLIGALL 234
 
Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 59-322 7.83e-84

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


Pssm-ID: 460391  Cd Length: 237  Bit Score: 253.19  E-value: 7.83e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720    59 VVPVLIVSNGLKKKSLDHSGALGGLVVGFILTIANFS--FFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKEGGQRNWVQV 136
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   137 FCNGAVPTELALLYMiengpgeipvdFSKQYSASWMCLSLLAALACSAGDTWASEVGPVLSKsSPRLITTWEKVPVGTNG 216
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720   217 GVTVVGLVSSLLGGTFVGIAYFLTQLifvndldisapqwpIIAFGGLAGLLGSIVDSYLGATMQYTGLDESTGMVVNSPT 296
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIVEGPG 214

                         250       260
                  ....*....|....*....|....*.
gi 21361720   297 nkaRHIAGKPILDNNAVNLFSSVLIA 322
Cdd:pfam01940 215 ---RKISGWDWLDNNAVNFLSTLIGA 237
COG1836 COG1836
Cytidylyltransferase family enzyme [General function prediction only];
49-324 1.09e-55

Cytidylyltransferase family enzyme [General function prediction only];


Pssm-ID: 441441  Cd Length: 243  Bit Score: 181.53  E-value: 1.09e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720  49 ISPWRWLFSVVVPVLIVSNGLKKKSLDHSGALGGLVVGFIL-TIANFSFFTSLLMFFLSSSKLTKWKGEVKKRLDSEYKE 127
Cdd:COG1836   2 VLLNPLLLALALSLLLGYLAYRKKLLTLSGALAAVLLGTLIiGLGGWGWFLLLLLFFILGSLLTKYGYKRKEALGIAEEK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720 128 GGQRNWVQVFCNGAVPTELALLYMiengpgeipvdFSKQYSASWMcLSLLAALACSAGDTWASEVGpVLSKSSPRLITTW 207
Cdd:COG1836  82 GGARGAGNVLANGGVALLAALLYA-----------ATPDDSPLFL-LAFAGSLATALADTWASEIG-VLSGKRPRLITTL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361720 208 EKVPVGTNGGVTVVGLVSSLLGGTFVGIAYFLTQLIfvndldisaPQWPIIAFGGLAGLLGSIVDSYLGATMQytgldes 287
Cdd:COG1836 149 KPVPPGTSGGVSLLGTLAGLLGALLIALLAWLLGLI---------DSLLGLLIVVLAGFLGTLVDSLLGATLQ------- 212

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21361720 288 tgmvvnsptnkarhiAGKPILDNNAVNLFSSVLIALL 324
Cdd:COG1836 213 ---------------NKYGWLTNDGVNFLATLIGALL 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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