NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62988331|ref|NP_060811|]
View 

endoplasmic reticulum membrane-associated RNA degradation protein isoform 1 [Homo sapiens]

Protein Classification

DUF4209 domain-containing protein( domain architecture ID 10621441)

DUF4209 domain-containing protein similar to the endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD), which may play a role in neuronal migration during embryonic development

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-214 4.97e-30

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 113.53  E-value: 4.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62988331   133 LERALGDVFLLIG-------KECPFLLRDLLSSEELAQVFSQSVMNVLKVFVGSPCGLNLRNVLWHGFASPEEIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 62988331   206 MMILLTAGL 214
Cdd:pfam13910  81 FLLLLLASL 89
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-214 4.97e-30

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 113.53  E-value: 4.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62988331   133 LERALGDVFLLIG-------KECPFLLRDLLSSEELAQVFSQSVMNVLKVFVGSPCGLNLRNVLWHGFASPEEIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 62988331   206 MMILLTAGL 214
Cdd:pfam13910  81 FLLLLLASL 89
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 133-214 4.97e-30

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 113.53  E-value: 4.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62988331   133 LERALGDVFLLIG-------KECPFLLRDLLSSEELAQVFSQSVMNVLKVFVGSPCGLNLRNVLWHGFASPEEIPPKYCS 205
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 62988331   206 MMILLTAGL 214
Cdd:pfam13910  81 FLLLLLASL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH