ERBB receptor feedback inhibitor 1 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 super family | cl13070 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
315-367 | 5.41e-11 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. The actual alignment was detected with superfamily member pfam11555: Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 58.47 E-value: 5.41e-11
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| GTPase_binding super family | cl07587 | GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its ... |
6-69 | 5.14e-04 | ||
GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42. The actual alignment was detected with superfamily member pfam09027: Pssm-ID: 430374 Cd Length: 66 Bit Score: 38.11 E-value: 5.14e-04
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| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 | pfam11555 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
315-367 | 5.41e-11 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 58.47 E-value: 5.41e-11
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| GTPase_binding | pfam09027 | GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its ... |
6-69 | 5.14e-04 | ||
GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42. Pssm-ID: 430374 Cd Length: 66 Bit Score: 38.11 E-value: 5.14e-04
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| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 | pfam11555 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
315-367 | 5.41e-11 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 58.47 E-value: 5.41e-11
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| GTPase_binding | pfam09027 | GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its ... |
6-69 | 5.14e-04 | ||
GTPase binding; The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42. Pssm-ID: 430374 Cd Length: 66 Bit Score: 38.11 E-value: 5.14e-04
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| Blast search parameters | ||||
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