|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
572-754 |
1.81e-130 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 399.29 E-value: 1.81e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17975 81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
571-1271 |
8.62e-126 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 410.63 E-value: 8.62e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGG-RIGMLEPRRLAARAAAERMAEELGEP- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:COG1643 83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:COG1643 159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEV---------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 810 EYIPVQTGAhADLNPfyqkyssrtqhAIlymnphkinLDLILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643 193 RYRPLPADE-RDLED-----------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 890 dRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643 241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHiMKC-NLGSPEDFlsKALDPPQLQVISN 1048
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttpigRKDeadlaksal 1128
Cdd:COG1643 397 ARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1129 amADSDHLTIYNAylgWKKARQEggyrseitycRRNFLNRTSLLTLEDVKQELIKLVKAAgfsssttstswegnRASQTL 1208
Cdd:COG1643 462 --AGSDLLARLNL---WRRLREQ----------QREFLSYLRLREWRDLARQLRRLLGEG--------------ANEEPA 512
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67782362 1209 SFQEIALLkavLVAGLYDNVGKiiytKSVDVTE-KLACivetaQGKAQVHPSSvnrDLQTHGWL 1271
Cdd:COG1643 513 DYEAIGLL---LALAYPDRIAR----RRGEGGRyLLAR-----GRGAALFPGS---PLAKKEWL 561
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
570-1190 |
2.77e-89 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 317.39 E-value: 2.77e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 570 QQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdllLNEweASKCNIVCTQPRRISAVSLANRVCDELGCE 649
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE---LGR--GVKGLIGHTQPRRLAARTVANRIAEELETE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 650 NGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH 729
Cdd:PRK11131 146 LG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEV---------------------------------------------- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 810 EYIPVQTGAHAdlnpfyqkySSRTQ-HAIlymnphkinLDLILELLAyldKSPqfrnieGAVLIFLPGLAHIQQLYDLLS 888
Cdd:PRK11131 255 RYRPIVEEADD---------TERDQlQAI---------FDAVDELGR---EGP------GDILIFMSGEREIRDTADALN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 889 NDRRFYSErykVIALHSILSTQDQAAAFTlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVET 968
Cdd:PRK11131 308 KLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 969 FVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISN 1048
Cdd:PRK11131 383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQD 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACELNEP----KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLA 1124
Cdd:PRK11131 461 GVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEK 540
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 1125 KSALAMADSDHLTIYNA--YLG-WKKARQEGGYRSEityCRRNFLNRTSLLTLEDVKQELIKLVKAAGF 1190
Cdd:PRK11131 541 HRRFADKESDFLAFVNLwnYLQeQQKALSSNQFRRL---CRTDYLNYLRVREWQDIYTQLRQVVKELGI 606
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
837-994 |
2.84e-67 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 223.95 E-value: 2.84e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 837 ILYMNPHKINLDLILELLAYLDKSpqfrNIEGAVLIFLPGLAHIQQLYDLL-SNDRRFYSERYKVIALHSILSTQDQAAA 915
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIHRT----EEPGDILVFLPGQEEIERLCELLrEELLSPDLGKLLVLPLHSSLPPEEQQRV 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 916 FTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMY 994
Cdd:cd18791 93 FEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
578-764 |
1.24e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 102.96 E-value: 1.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 578 RDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASKCNIVCTQPRRisavSLANRVCDELGCENGPGGRNS 657
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTR----ELAEQWAEELKKLGPSLGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 658 LC---GYQIRMESRACES--TRLLYCTTGVLLRKLQEDGL-LSNVSHVIVDEVHERSVQsDFLLIILKEILQKRSDLHLI 731
Cdd:smart00487 86 VGlygGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLLPKNVQLL 164
|
170 180 190
....*....|....*....|....*....|....*..
gi 67782362 732 LMSAT--VDSEKFSTYFTHCP--ILRISGRSYPVEVF 764
Cdd:smart00487 165 LLSATppEEIENLLELFLNDPvfIDVGFTPLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1049-1138 |
8.46e-21 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 88.45 E-value: 8.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGAceLNE-PKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIG----------- 1116
Cdd:pfam04408 1 ALELLYYLGA--LDEdGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaar 78
|
90 100
....*....|....*....|....*.
gi 67782362 1117 ----RKDEADLAKSALAMADSDHLTI 1138
Cdd:pfam04408 79 rrrrAADEKARAKFARLDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
1056-1137 |
1.89e-20 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 86.94 E-value: 1.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1056 IGACELNEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttPIGRKDEADLAKSALAMADSDH 1135
Cdd:smart00847 2 LGALDDDG-RLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDH 78
|
..
gi 67782362 1136 LT 1137
Cdd:smart00847 79 LT 80
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
580-740 |
6.14e-13 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 68.04 E-value: 6.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 580 SIVETLKRHRVVVVAGETGSGKST--QVPhflLEDLLLNEWEASKCNIVCtqPRRisavSLAN---RVCDELGCENGPGG 654
Cdd:pfam00270 6 EAIPAILEGRDVLVQAPTGSGKTLafLLP---ALEALDKLDNGPQALVLA--PTR----ELAEqiyEELKKLGKGLGLKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 655 RNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHeRSVQSDFLLIILKEILQKRSDLHLILMS 734
Cdd:pfam00270 77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLS 155
|
....*.
gi 67782362 735 ATVDSE 740
Cdd:pfam00270 156 ATLPRN 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
572-754 |
1.81e-130 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 399.29 E-value: 1.81e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17975 81 PGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
571-1271 |
8.62e-126 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 410.63 E-value: 8.62e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGG-RIGMLEPRRLAARAAAERMAEELGEP- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:COG1643 83 -VGET---VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:COG1643 159 LLVMSATLDAERFARLLGDAPVIESSGRTYPVEV---------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 810 EYIPVQTGAhADLNPfyqkyssrtqhAIlymnphkinLDLILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLsn 889
Cdd:COG1643 193 RYRPLPADE-RDLED-----------AV---------ADAVREAL---------AEEPGDILVFLPGEREIRRTAEAL-- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 890 dRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:COG1643 241 -RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHiMKC-NLGSPEDFlsKALDPPQLQVISN 1048
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE-LAAwGLGDPEDL--PFLDPPPARAIAD 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttpigRKDeadlaksal 1128
Cdd:COG1643 397 ARALLQELGALD-ADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGA--------- 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1129 amADSDHLTIYNAylgWKKARQEggyrseitycRRNFLNRTSLLTLEDVKQELIKLVKAAgfsssttstswegnRASQTL 1208
Cdd:COG1643 462 --AGSDLLARLNL---WRRLREQ----------QREFLSYLRLREWRDLARQLRRLLGEG--------------ANEEPA 512
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67782362 1209 SFQEIALLkavLVAGLYDNVGKiiytKSVDVTE-KLACivetaQGKAQVHPSSvnrDLQTHGWL 1271
Cdd:COG1643 513 DYEAIGLL---LALAYPDRIAR----RRGEGGRyLLAR-----GRGAALFPGS---PLAKKEWL 561
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
570-1190 |
2.77e-89 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 317.39 E-value: 2.77e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 570 QQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdllLNEweASKCNIVCTQPRRISAVSLANRVCDELGCE 649
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE---LGR--GVKGLIGHTQPRRLAARTVANRIAEELETE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 650 NGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH 729
Cdd:PRK11131 146 LG-----GCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEVfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyq 809
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEV---------------------------------------------- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 810 EYIPVQTGAHAdlnpfyqkySSRTQ-HAIlymnphkinLDLILELLAyldKSPqfrnieGAVLIFLPGLAHIQQLYDLLS 888
Cdd:PRK11131 255 RYRPIVEEADD---------TERDQlQAI---------FDAVDELGR---EGP------GDILIFMSGEREIRDTADALN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 889 NDRRFYSErykVIALHSILSTQDQAAAFTlpPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVET 968
Cdd:PRK11131 308 KLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 969 FVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISN 1048
Cdd:PRK11131 383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQD 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGACELNEP----KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLA 1124
Cdd:PRK11131 461 GVRLLEELGAITTDEQasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEK 540
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 1125 KSALAMADSDHLTIYNA--YLG-WKKARQEGGYRSEityCRRNFLNRTSLLTLEDVKQELIKLVKAAGF 1190
Cdd:PRK11131 541 HRRFADKESDFLAFVNLwnYLQeQQKALSSNQFRRL---CRTDYLNYLRVREWQDIYTQLRQVVKELGI 606
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
588-754 |
1.31e-86 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 278.57 E-value: 1.31e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 588 HRVVVVAGETGSGKSTQVPHFLLEDLLLNEweaSKCNIVCTQPRRISAVSLANRVCDELGCENGpggrnSLCGYQIRMES 667
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKG---GKGRIVCTQPRRIAAISVAERVAEERGEKLG-----EEVGYQIRFES 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 668 RACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFT 747
Cdd:cd17917 73 KTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFG 152
|
....*..
gi 67782362 748 HCPILRI 754
Cdd:cd17917 153 GAPVIHI 159
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
572-754 |
8.16e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 228.91 E-value: 8.16e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnEWEASKCNIVCTQPRRISAVSLANRVCDELGceng 651
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVL-RGRGARCNVVITQPRRISAVSVAQRVAHELG---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRNSLcGYQIRMESRACEST-RLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17976 76 PNLRRNV-GYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRV 154
|
170 180
....*....|....*....|....
gi 67782362 731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17976 155 VLMSATGDNQRLSRYFGGCPVVRV 178
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
837-994 |
2.84e-67 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 223.95 E-value: 2.84e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 837 ILYMNPHKINLDLILELLAYLDKSpqfrNIEGAVLIFLPGLAHIQQLYDLL-SNDRRFYSERYKVIALHSILSTQDQAAA 915
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIHRT----EEPGDILVFLPGQEEIERLCELLrEELLSPDLGKLLVLPLHSSLPPEEQQRV 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 916 FTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMY 994
Cdd:cd18791 93 FEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
572-754 |
1.12e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 222.80 E-value: 1.12e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnEWEASKCNIVCTQPRRISAVSLANRVCDELgCENG 651
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIE-RGKGSSCRIVCTQPRRISAISVAERVAAER-AESC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRNSlcGYQIRMESR-ACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17981 79 GLGNST--GYQIRLESRkPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKV 156
|
170 180
....*....|....*....|....
gi 67782362 731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17981 157 ILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
520-754 |
8.76e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 222.40 E-value: 8.76e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 520 PEESWENLVSDE-DFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETG 598
Cdd:cd17972 6 PQSNWNPWTSSNiDEGPLAFATPEQISMDLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 599 SGKSTQVPHFLLEDLLLNEwEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGgrnslCGYQIRMES---RACEStrL 675
Cdd:cd17972 86 CGKTTQVPQYILDDFIQND-RAAECNIVVTQPRRISAVSVAERVAFERGEEVGKS-----CGYSVRFESvlpRPHAS--I 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 676 LYCTTGVLLRKLqEDGLlSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17972 158 LFCTVGVLLRKL-EAGI-RGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
571-1110 |
3.10e-65 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 238.29 E-value: 3.10e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 571 QLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPhflLEDLLLNEWEAskcNIVCTQPRRISAVSLANRVCDELGCEn 650
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLLQHGGING---KIIMLEPRRLAARNVAQRLAEQLGEK- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 651 gPGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQK-RSDLH 729
Cdd:PRK11664 76 -PGET---VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 730 LILMSATVDSEKFSTYFTHCPILRISGRSYPVEvfhlediieetgfvlekdseycqkfleeeeevtinvtskaggikkyQ 809
Cdd:PRK11664 152 LLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVE----------------------------------------------R 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 810 EYIPVqtGAHadlNPFYQKYSSRtqhailymnphkinldlILELLayldkspqfRNIEGAVLIFLPGLAHIQQLYDLLSN 889
Cdd:PRK11664 186 RYQPL--PAH---QRFDEAVARA-----------------TAELL---------RQESGSLLLFLPGVGEIQRVQEQLAS 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 890 DrrfYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETF 969
Cdd:PRK11664 235 R---VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQR 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 970 VSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCLHIMKCNLGSPEDFlsKALDPPQLQVISNA 1049
Cdd:PRK11664 312 ISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQL--SWLDQPPAAALAAA 389
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67782362 1050 MNLLRKIGACElNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFG-CLDPVATLAAVMTEKSP 1110
Cdd:PRK11664 390 KRLLQQLGALD-GQGRLTARGRKMAALGNDPRLAAMLVAAKEDDeAALATAAKLAAILEEPP 450
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
572-754 |
3.80e-65 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 218.17 E-value: 3.80e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASkCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPV-ANIICTQPRRISAISVAERVAQERAERVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17985 80 -----QSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVI 154
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17985 155 LMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
572-754 |
9.40e-59 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 200.06 E-value: 9.40e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNeweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAN---GIPCRIFCTQPRRLAAIAVAERVAAERGEKIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQE-DGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17987 78 -----QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKL 152
|
170 180
....*....|....*....|....
gi 67782362 731 ILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17987 153 ILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
560-754 |
3.02e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 196.10 E-value: 3.02e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 560 PKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnewEASKCNIVCTQPRRISAVSLA 639
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELP---HQPKKLVACTQPRRVAAMSVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 640 NRVCDELGCENGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILK 719
Cdd:cd17973 78 QRVAEEMDVKLG-----EEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLK 152
|
170 180 190
....*....|....*....|....*....|....*
gi 67782362 720 EILQKRSDLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17973 153 EVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
572-754 |
1.34e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 190.73 E-value: 1.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLA--------AGFRHIACTQPRRIACISLAKRVAFESLNQYG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17979 73 -----SKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLI 147
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17979 148 LMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
572-754 |
7.98e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 182.94 E-value: 7.98e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDlllneWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEA-----GFARGGMIGITQPRRVAAVSVAKRVAEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKR-----S 726
Cdd:cd17978 76 -----QLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklS 150
|
170 180
....*....|....*....|....*...
gi 67782362 727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17978 151 PLKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
572-747 |
2.50e-51 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 178.85 E-value: 2.50e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASK-CNIVCTQPRRISAVSLANRVCDELGCEN 650
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYY----KRGKyCNIVVTQPRRIAAISIARRVSQEREWTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 651 GpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSD-LH 729
Cdd:cd17988 77 G-----SLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVK 151
|
170
....*....|....*...
gi 67782362 730 LILMSATVDSEKFSTYFT 747
Cdd:cd17988 152 IILMSATISCKEFADYFT 169
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
572-746 |
2.04e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 176.51 E-value: 2.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE----AGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACE-STRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHL 730
Cdd:cd17980 77 -----HEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRL 151
|
170
....*....|....*.
gi 67782362 731 ILMSATVDSEKFSTYF 746
Cdd:cd17980 152 IVASATLDAEKFRDFF 167
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
568-754 |
6.53e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 174.59 E-value: 6.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 568 ERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEdlllnEWEASKCNIVCTQPRRISAVSLANRVCDELG 647
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE-----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 648 CENGpggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSD 727
Cdd:cd17971 77 CCLG-----QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD 151
|
170 180
....*....|....*....|....*..
gi 67782362 728 LHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17971 152 LKLIVTSATLDAVKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
572-754 |
4.73e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 171.88 E-value: 4.73e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGY-----TDYGMIGCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17983 76 -----EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLI 150
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17983 151 VTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
572-754 |
4.89e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 169.22 E-value: 4.89e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDlllnEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA----GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17974 77 -----NEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLL 151
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17974 152 ISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
572-754 |
2.09e-47 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 167.25 E-value: 2.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGR-----GIRGLIGHTQPRRLAARSVAERIAEELKTELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17989 76 -----GAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVI 150
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17989 151 ITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
572-743 |
2.17e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 165.22 E-value: 2.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELgceNG 651
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEEL---NV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLH-- 729
Cdd:cd17982 78 FGKE---VSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYlq 154
|
170 180
....*....|....*....|..
gi 67782362 730 --------LILMSATVDSEKFS 743
Cdd:cd17982 155 dqtvkplkLVIMSATLRVEDFT 176
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
572-754 |
4.87e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 149.23 E-value: 4.87e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlneweASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF-----SQHGMIGVTQPRRVAAISVAQRVAEEMKCTLG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRS----- 726
Cdd:cd17984 76 -----SKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrke 150
|
170 180
....*....|....*....|....*...
gi 67782362 727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17984 151 HLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
572-753 |
1.23e-40 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 147.86 E-value: 1.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLnewEASKcnIVCTQPRRISAVSLANRVCDELGCEng 651
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWI---AGGK--IIVLEPRRVAARAAARRLATLLGEA-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQ-KRSDLHL 730
Cdd:cd17990 74 PGET---VGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRL 150
|
170 180
....*....|....*....|...
gi 67782362 731 ILMSATVDSEKFSTYFTHCPILR 753
Cdd:cd17990 151 LAMSATLDGDGLAALLPEAPVVE 173
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
572-754 |
1.54e-31 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 121.86 E-value: 1.54e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKcnIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGV--VVCTQVHKQTAVWLALRVADEMDVNIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 pggrnSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLI 731
Cdd:cd17977 79 -----HEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLV 153
|
170 180
....*....|....*....|...
gi 67782362 732 LMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17977 154 IITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
572-754 |
7.45e-25 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 102.67 E-value: 7.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 572 LPVFKHRDSIVETLKRHR-VVVVAGETGSGKSTQVPHFLLEDLLLNEWeaSKCNIVCTQPRRISAVSLANRVCDE----L 646
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRGF--QKGQVTVTQPHPLAARSLALRVADEmdlnL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 647 GCEngpggrnslCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRS 726
Cdd:cd17986 79 GHE---------VGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRP 149
|
170 180
....*....|....*....|....*...
gi 67782362 727 DLHLILMSATVDSEKFSTYFTHCPILRI 754
Cdd:cd17986 150 ELRVVVVTSPALEPKLRAFWGNPPVVHV 177
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
578-764 |
1.24e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 102.96 E-value: 1.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 578 RDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLlnewEASKCNIVCTQPRRisavSLANRVCDELGCENGPGGRNS 657
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTR----ELAEQWAEELKKLGPSLGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 658 LC---GYQIRMESRACES--TRLLYCTTGVLLRKLQEDGL-LSNVSHVIVDEVHERSVQsDFLLIILKEILQKRSDLHLI 731
Cdd:smart00487 86 VGlygGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLLPKNVQLL 164
|
170 180 190
....*....|....*....|....*....|....*..
gi 67782362 732 LMSAT--VDSEKFSTYFTHCP--ILRISGRSYPVEVF 764
Cdd:smart00487 165 LLSATppEEIENLLELFLNDPvfIDVGFTPLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1049-1138 |
8.46e-21 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 88.45 E-value: 8.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1049 AMNLLRKIGAceLNE-PKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIG----------- 1116
Cdd:pfam04408 1 ALELLYYLGA--LDEdGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaar 78
|
90 100
....*....|....*....|....*.
gi 67782362 1117 ----RKDEADLAKSALAMADSDHLTI 1138
Cdd:pfam04408 79 rrrrAADEKARAKFARLDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
1056-1137 |
1.89e-20 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 86.94 E-value: 1.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1056 IGACELNEpKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFttPIGRKDEADLAKSALAMADSDH 1135
Cdd:smart00847 2 LGALDDDG-RLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDH 78
|
..
gi 67782362 1136 LT 1137
Cdd:smart00847 79 LT 80
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1216-1302 |
2.22e-16 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 75.37 E-value: 2.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 1216 LKAVLVAGLYDNVGKIIYTKSVDVTEKLacivetaQGKAQVHPSSVNRDLQTH--GWLLYQEKIRYARVYLRETTLITPF 1293
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSD-------NQRVFIHPSSVLFNEKTFppEWVVYQELVETTKVYIRTVTAISPE 73
|
....*....
gi 67782362 1294 PVLLFGGDI 1302
Cdd:pfam07717 74 WLLLFAPHI 82
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
881-984 |
2.65e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 69.16 E-value: 2.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 881 QQLYDLLSNdrrfysERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGrtkenkyhess 960
Cdd:smart00490 1 EELAELLKE------LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD----------- 63
|
90 100
....*....|....*....|....
gi 67782362 961 qmsslveTFVSKASALQRQGRAGR 984
Cdd:smart00490 64 -------LPWSPASYIQRIGRAGR 80
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
591-736 |
8.25e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.12 E-value: 8.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 591 VVVAGETGSGKSTQVPHFLLEDLLLNEweaskCNIVCTQPRRISAVSLANRVCDELGcengpggRNSLCGYQIRMESrAC 670
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKG-----KKVLVLVPTKALALQTAERLRELFG-------PGIRVAVLVGGSS-AE 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67782362 671 ESTR-------LLYCTTGVLLRKLQEDGLL--SNVSHVIVDEVHERSVQSDFLLII-LKEILQKRSDLHLILMSAT 736
Cdd:cd00046 71 EREKnklgdadIIIATPDMLLNLLLREDRLflKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
580-740 |
6.14e-13 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 68.04 E-value: 6.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 580 SIVETLKRHRVVVVAGETGSGKST--QVPhflLEDLLLNEWEASKCNIVCtqPRRisavSLAN---RVCDELGCENGPGG 654
Cdd:pfam00270 6 EAIPAILEGRDVLVQAPTGSGKTLafLLP---ALEALDKLDNGPQALVLA--PTR----ELAEqiyEELKKLGKGLGLKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 655 RNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHeRSVQSDFLLIILKEILQKRSDLHLILMS 734
Cdd:pfam00270 77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLS 155
|
....*.
gi 67782362 735 ATVDSE 740
Cdd:pfam00270 156 ATLPRN 161
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
847-985 |
3.56e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 61.46 E-value: 3.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 847 LDLILELLAyldkspqfRNIEGAVLIFLPGLAHIQqlYDLLSNdrrfySERYKVIALHSILSTQDQAAAFTLPPPGVRKI 926
Cdd:pfam00271 3 LEALLELLK--------KERGGKVLIFSQTKKTLE--AELLLE-----KEGIKVARLHGDLSQEEREEILEDFRKGKIDV 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 67782362 927 VLATNIAETGITIPDVVFVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGRV 985
Cdd:pfam00271 68 LVATDVAERGLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGRA 108
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
581-1055 |
1.99e-10 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 65.38 E-value: 1.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 581 IVETLKRHRVVVVAGETGSGKSTQVPHFLL---------EDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENG 651
Cdd:PHA02653 172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfDNLDKIDPNFIERPIVLSLPRVALVRLHSITLLKSLGFDEI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 652 PGGRNSLCGYQIRMESR--ACESTRLLYCTTGVLLRKLqedgllSNVSHVIVDEVHERSVQSDFLLIIL-KEILQKRSdl 728
Cdd:PHA02653 252 DGSPISLKYGSIPDELIntNPKPYGLVFSTHKLTLNKL------FDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIRS-- 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 729 hLILMSATvdsekfstyfthcpilrisgrsypvevfhlediieetgfvLEKDSEYCQKFLEEEEEVtinvtskaggikky 808
Cdd:PHA02653 324 -LFLMTAT----------------------------------------LEDDRDRIKEFFPNPAFV-------------- 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 809 qeYIPVQTgahadLNPF---YQKYSSRTQHAILYMNPHKINLDLILELLAYLDKSpqfrniegAVLIFLPGLAHIQQLYD 885
Cdd:PHA02653 349 --HIPGGT-----LFPIsevYVKNKYNPKNKRAYIEEEKKNIVTALKKYTPPKGS--------SGIVFVASVSQCEEYKK 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 886 LLSNdrrfYSERYKVIALHSILSTQDQAAAFTLPPPGVrKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMssl 965
Cdd:PHA02653 414 YLEK----RLPIYDFYIIHGKVPNIDEILEKVYSSKNP-SIIISTPYLESSVTIRNATHVYDTGRVYVPEPFGGKEM--- 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 966 vetFVSKASALQRQGRAGRVRDGFCFRMYTrerfegfMDYSVPeILRVPLEELCLHIM---KCNLGSPEDFLskaldppq 1042
Cdd:PHA02653 486 ---FISKSMRTQRKGRVGRVSPGTYVYFYD-------LDLLKP-IKRIDSEFLHNYILyakYFNLTLPEDLF-------- 546
|
490
....*....|...
gi 67782362 1043 lqVISNAMNLLRK 1055
Cdd:PHA02653 547 --VIPSNLDRLRK 557
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
510-942 |
2.84e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 58.11 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 510 SENKRENSEDPEESWENLVSDEDFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHR---------DS 580
Cdd:COG1061 12 DKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFElrpyqqealEA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 581 IVETLKRH--RVVVVAGeTGSGKSTqvphFLLEDLllnEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSl 658
Cdd:COG1061 92 LLAALERGggRGLVVAP-TGTGKTV----LALALA---AELLRGKRVLVLVPRRELLEQWAEELRRFLGDPLAGGGKKD- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 659 cgyqirmesracESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSdflliiLKEILQKRSDLHLILMSATvd 738
Cdd:COG1061 163 ------------SDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT-- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 739 sekfstyfthcPIlRISGRsyPVEVFHLEDIIEETGfvlekdseycqkfLEEEEEvtinvtskAGGIKKYqEYIPVqtga 818
Cdd:COG1061 223 -----------PF-RSDGR--EILLFLFDGIVYEYS-------------LKEAIE--------DGYLAPP-EYYGI---- 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 819 HADLNPFYQKYSSRTQHAILYMNPHKINLDLILEllAYLDKSPQFRniegAVLIFLPGLAHIQQLYDLLSndrrfySERY 898
Cdd:COG1061 263 RVDLTDERAEYDALSERLREALAADAERKDKILR--ELLREHPDDR----KTLVFCSSVDHAEALAELLN------EAGI 330
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 67782362 899 KVIALHSILSTQDQA---AAFTLpppGVRKIVLATNIAETGITIPDV 942
Cdd:COG1061 331 RAAVVTGDTPKKEREeilEAFRD---GELRILVTVDVLNEGVDVPRL 374
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
571-754 |
2.91e-06 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 49.18 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 571 QLPVFKHRDsivetLKRHRVVVVAGeTGSGKStqvphFLLEDLLLNEWEASKCNIVCTQPRRisavSLANRVCDELGCEN 650
Cdd:cd17921 6 QREALRALY-----LSGDSVLVSAP-TSSGKT-----LIAELAILRALATSGGKAVYIAPTR----ALVNQKEADLRERF 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 651 GPGGRN-SLCGYQIRMESRACESTRLLYCTT---GVLLRKLQEDgLLSNVSHVIVDEVH--ERSVQSDFLLIILKEILQK 724
Cdd:cd17921 71 GPLGKNvGLLTGDPSVNKLLLAEADILVATPeklDLLLRNGGER-LIQDVRLVVVDEAHliGDGERGVVLELLLSRLLRI 149
|
170 180 190
....*....|....*....|....*....|.
gi 67782362 725 RSDLHLILMSATVDS-EKFSTYFTHCPILRI 754
Cdd:cd17921 150 NKNARFVGLSATLPNaEDLAEWLGVEDLIRF 180
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
925-984 |
1.46e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.54 E-value: 1.46e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 67782362 925 KIVLATNIAETGITIPDVVFVIDTGRTKenkyhessqmsslvetfvSKASALQRQGRAGR 984
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGR 65
|
|
| |
