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Conserved domains on  [gi|21265096|ref|NP_061924|]
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large ribosomal subunit protein mL50 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L50 super family cl11141
Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger ...
 60-154 1.35e-10

Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units. Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components. In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes.


The actual alignment was detected with superfamily member pfam10501:

Pssm-ID: 402226  Cd Length: 109  Bit Score: 54.98  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265096    60 YTPPEDLQSRLESYVKEVFGSSLPS--NWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDR 137
Cdd:pfam10501   1 VSESEELDEIVAETYSEAFGAPGDGdkGFLSLSLDDLSFKFAFLKRLQQLTGHDIPDYKLTKLHTVADLVNYLEEVLSPK 80

                          90       100
                  ....*....|....*....|....*.
gi 21265096   138 -SKFDE--------LSASNLPPNLKI 154
Cdd:pfam10501  81 pKKLAErlpnaivlRREDFKLPNVYI 106
 
Name Accession Description Interval E-value
Ribosomal_L50 pfam10501
Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger ...
 60-154 1.35e-10

Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units. Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components. In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes.


Pssm-ID: 402226  Cd Length: 109  Bit Score: 54.98  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265096    60 YTPPEDLQSRLESYVKEVFGSSLPS--NWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDR 137
Cdd:pfam10501   1 VSESEELDEIVAETYSEAFGAPGDGdkGFLSLSLDDLSFKFAFLKRLQQLTGHDIPDYKLTKLHTVADLVNYLEEVLSPK 80

                          90       100
                  ....*....|....*....|....*.
gi 21265096   138 -SKFDE--------LSASNLPPNLKI 154
Cdd:pfam10501  81 pKKLAErlpnaivlRREDFKLPNVYI 106
 
Name Accession Description Interval E-value
Ribosomal_L50 pfam10501
Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger ...
 60-154 1.35e-10

Ribosomal subunit 39S; The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units. Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components. In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes.


Pssm-ID: 402226  Cd Length: 109  Bit Score: 54.98  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265096    60 YTPPEDLQSRLESYVKEVFGSSLPS--NWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDR 137
Cdd:pfam10501   1 VSESEELDEIVAETYSEAFGAPGDGdkGFLSLSLDDLSFKFAFLKRLQQLTGHDIPDYKLTKLHTVADLVNYLEEVLSPK 80

                          90       100
                  ....*....|....*....|....*.
gi 21265096   138 -SKFDE--------LSASNLPPNLKI 154
Cdd:pfam10501  81 pKKLAErlpnaivlRREDFKLPNVYI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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