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Conserved domains on  [gi|148491097|ref|NP_062099|]
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cytoplasmic dynein 1 heavy chain 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1044-4327 0e+00

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1199.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1044 EVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSKWQALLVQIRRARGTFDNAETKKEF-GPVVIDYGKVQSKVNLKYDSWh 1122
Cdd:COG5245   170 SVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVATLDSLlSSSKYSELGRRLHFYANMDFS- 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1123 kevlskfGQMLGSNMTEFHSQISKSRQEL--EQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRF 1200
Cdd:COG5245   249 -------GIYFPKSFSEFKDSVISATQAVsrDIGRQSRMARRLILVQMDSLARLIVDRICEYVSIEWLGCCEELLTCSME 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1201 QFPPSWLYIDNIEgewgafNDIMRRKDSAIQQQvaNLQMKIVQEDRAVESRTTDLLTDWE-----KTKPVTGNLRPEEAL 1275
Cdd:COG5245   322 SMSSLVNSFDGEE------SEAMSLESSLFYEF--RGGEHLAGFYSAFGDIKRILLFTWSfkklgTLLPSLPGYSSGGMD 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1276 QALTIYEGKFGRLKDDREKCAKAKEALELTDTgllsgSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQpr 1355
Cdd:COG5245   394 YGEEYRSLLWELGSEVGDPDSGPVRKWMRKDL-----FDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTLEDDE-- 466
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1356 KLRQNLDGLLNQlknfpARLRQYASYEFVQRLlkgYMKINML------VIELKSEALKdrHWKQLMKrlhvnwvvseltl 1429
Cdd:COG5245   467 EDTPALAILLGQ-----EEAGRFVKLCKIMRM---FSFFNSLemfsrrTLANRMAIVK--YLSSVVR------------- 523
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1430 gqIWDVDLQKN-----EAIVKDVLLVAqgEMALEEFLKQIREVWNTYELDLVNYQNKC------RLIRGWddlfnkVKEH 1498
Cdd:COG5245   524 --TGPLFLQRDffgrmSELLMARDMFM--EVDGVLRLFFGGEWSGIVQLSGIRRAKRCverqidDEIREW------CSSV 593
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1499 INSVSAMKLSPYykvFEEDAlsweDKLNRIMALFDVWIdvqRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMK 1578
Cdd:COG5245   594 LSDDFLEERAVR---VERGA----DGARRLRASSGSPV---LRRLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYK 663
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1579 KVSKSPLVMDVLNIQgVQRSLERLADLLGKIQKALGEYLERERSSFPRFyfVGDEDLLEIIGNSKNVAKLQKHFKKMFAG 1658
Cdd:COG5245   664 RVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAK 740
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1659 VSSIILNEDSsvVLGISSREGEEVMFKTPVSITEHPKINEWLTlvEKEMRVtLAKLLaesvtevEIFGKATSIDPNTYIt 1738
Cdd:COG5245   741 EEMKTVFSSR--IQKKEPFSLDSEAYVGFFRLYEKSIVIRGIN--RSMGRV-LSQYL-------ESVQEALEIEDGSFF- 807
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1739 wIDKYQAQLVVLSAQIaWSENVENALSNvggggdvgPLQSVLSNVEVT----LNVLADSVLmeqpplrrRKLEHLITELV 1814
Cdd:COG5245   808 -VSRHRVRDGGLEKGR-GCDAWENCFDP--------PLSEYFRILEKIfpseEGYFFDEVL--------KRLDPGHEIKS 869
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1815 HQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMAnakfnYGFEYLGVQDKLVQTPLTDRCYLTMTQAL 1894
Cdd:COG5245   870 RIEEIIRMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSA-----EMFAKNTIPFFVFEHSMDTSQHQKLFEAV 944
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1895 EARLggSPFgpAGTGKTESVKALGHQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERMLsAVSQQVQ 1974
Cdd:COG5245   945 CDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR-TILVDEY 1010
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1975 CIQEALREHSNPNydktsapitcELLNKQVKVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTKPDRQLIAQvmlys 2054
Cdd:COG5245  1011 LNSDEFRMLEELN----------SAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGAIKSR----- 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2055 qgfrtAEVLANKIVPFFKLCDEQLSSQSHYDFglRALKSVLvsagnvkreriQKIKREKEERGEAVDEGEIAENLPeqei 2134
Cdd:COG5245  1072 -----RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-----------KAKHRMLEEKTEYLNKILSITGLP---- 1129
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2135 liqSVCETMVPklvaedipllfslLSDVFPGvqyhrgEMTALREelKKVCQEMYltygDGEEVGGMWVEKVLQLYQITQI 2214
Cdd:COG5245  1130 ---LISDTLRE-------------RIDTLDA------EWDSFCR--ISESLKKY----ESQQVSGLDVAQFVSFLRSVDT 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2215 NHGLMMVGPSGSGKSMAWRVLLKALerlegvegvAHIIDPKAIsKDHLYGTLdpntrEWTdGLFTHVLRkiiDNVRGELQ 2294
Cdd:COG5245  1182 GAFHAEYFRVFLCKIKHYTDACDYL---------WHVKSPYVK-KKYFDADM-----ELR-QFFLMFNR---EDMEARLA 1242
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2295 -KRQWIVFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRIMFEVQDlkyATLATVSRCGMVWFSEDVLSTDMIF 2373
Cdd:COG5245  1243 dSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVF 1307
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2374 NNFLARLRSiPLDEGEDEAQRRRKGKEDEGEeaaspmlqiqrdaatimqpyfTSNGLVTKALEHAFKLEHIMDLTRLRCL 2453
Cdd:COG5245  1308 LDELGDTKR-YLDECLDFFSCFEEVQKEIDE---------------------LSMVFCADALRFSADLYHIVKERRFSGV 1365
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2454 --GSLFSM-LHQACRNVAQyNANHPDfpmqieqLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRITTVPLPTAPN- 2529
Cdd:COG5245  1366 laGSDASEsLGGKSIELAA-ILEHKD-------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDLNERSDy 1437
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2530 --IPIIDYEVSISGE-WSPwqakVPQIEVETHKVAAP-DVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFS 2605
Cdd:COG5245  1438 eeMLIMMFNISAVITnNGS----IAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCP 1513
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2606 ALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMV 2685
Cdd:COG5245  1514 SLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLV 1593
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2686 EHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAE 2765
Cdd:COG5245  1594 ERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDEFNRLSE 1673
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2766 PLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTD 2845
Cdd:COG5245  1674 ETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSR 1753
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2846 ENIDMVALKHFPNIDKEKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFR 2925
Cdd:COG5245  1754 QDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLL 1833
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2926 QPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLER 3005
Cdd:COG5245  1834 VVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLED 1913
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3006 MNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFN 3085
Cdd:COG5245  1914 FNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKN 1993
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3086 RCVLNWFGDWSTEALYQVGKEFtskMDLEKPNYIVPDYMPVVydKLPQPPTHREAIVNSCVFVHQTLHQANARLAkrggr 3165
Cdd:COG5245  1994 RCFIDFKKLWDTEEMSQYANSV---ETLSRDGGRVFFINGEL--GVGKGALISEVFGDDAVVIEGRGFEISMIEG----- 2063
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3166 TMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQ 3245
Cdd:COG5245  2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGER 2143
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3246 QEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLL 3325
Cdd:COG5245  2144 LEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDL 2223
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3326 LGESTTDWKQIRSIIMRENFIPTIVNFSAE-EISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADML 3404
Cdd:COG5245  2224 LGFEAKIWFGEQQSLRRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3405 KRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAER 3484
Cdd:COG5245  2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3485 ERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTwSHHLQQANIQFRTDIART--EYLSNADERLRWQA 3562
Cdd:COG5245  2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEGVQKIEDFKEEA 2462
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3563 SSlpaDDLCTENA-IMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDP 3641
Cdd:COG5245  2463 CS---TDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDAEALDE 2539
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3642 VLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPD 3721
Cdd:COG5245  2540 EIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGP 2619
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3722 VDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLP 3801
Cdd:COG5245  2620 LFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNA 2699
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3802 LSTACSSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLyenpNLKGATDHTQRLSVITKDLFqvafnrvargMLHQDHITF 3881
Cdd:COG5245  2700 SVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR----RMKSKYLCAIRYMLMSSEWI----------LDHEDRSGF 2765
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3882 AMLLariklkgtmgeptydaEFQHFLRGKEIVLsagSTPKVQGLTVEQAEAVArlsclpAFKDLIakVQADEQFGiwLES 3961
Cdd:COG5245  2766 IHRL----------------DVSFLLRTKRFVS---TLLEDKNYRQVLSSCSL------YGNDVI--SHSCDRFD--RDV 2816
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3962 SSPEQTVPYLWTEETpatpigqaihRLLLIQAFRPDRLLAMAHMFVSTNLGEsFMSIMEqplDLTHIVGTEVKPNTPVLM 4041
Cdd:COG5245  2817 YRALKHQMDNRTHST----------ILTSNSKTNPYKEYTYNDSWAEAFEVE-DSGDLY---KFEEGLLELIVGHAPLIY 2882
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4042 CsvpgydasgHVEDLAAEQNTQitsiAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQL-----EKKLHSLQP 4116
Cdd:COG5245  2883 A---------HKKSLENERNVD----RLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYvedvvYPIKASRVC 2949
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4117 HACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVsrMCK-SPNERARLYFLLAWFHAVIQERLRYA 4195
Cdd:COG5245  2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDDAFYLSWEHAAVASVISAG 3027
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4196 PLGWSKKYEFGESDLRSACDTVDTWLddtAKGRQNispdKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTtrS 4275
Cdd:COG5245  3028 PKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLN----ARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGA--H 3098
                        3290      3300      3310      3320      3330
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148491097 4276 FDSEFKLACKVDGHKDIQ--MPDGIRREEFVQWVELLPDAQTPSWLGLPNNAER 4327
Cdd:COG5245  3099 ETSSQILASVPGGDPELVkfHMEEMCRSSAFGVIGQLPDLALCAWLMGPCDSEY 3152
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
240-830 1.30e-142

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


:

Pssm-ID: 462457  Cd Length: 560  Bit Score: 458.58  E-value: 1.30e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   240 LNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTG 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   320 LKQALETVNDYNPLMKDF--PLNDLLSATELDKIRQALVAIFTHLRKI-RNTKY--PIQRALRLVEAISRDLSSQLLKVL 394
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   395 GTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKReenlkmvWRINPAHR-----KLQARLDQMRKFRR 469
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   470 QHEQLRAV--IVRVLRPQVTAVaqqnqgeapepqdmkVAEVlfdaadanaIEEVNLAYENVKEV--DGLDVSKEGteaWE 545
Cdd:pfam08385  234 TIEQFSKLekIGGTKGPELEGV---------------IEEI---------LEEFQEAYKVFKSKtyDILDVSNEG---FD 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   546 AAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQY 625
Cdd:pfam08385  287 DDYEEFKERIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQK 366
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   626 pqsQACKMSHvRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGweNHVEGQKLKQDGDSFRMKLN--TQEIFDDWARK 703
Cdd:pfam08385  367 ---YNPSPIA-KNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKE 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   704 VQQRNLGVSGR-IFTIESARVRgrsgnvlKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIES 782
Cdd:pfam08385  441 VEEASEGNLKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELL 513
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 148491097   783 VRTYERTCEKV--EERNtislLVAGLKKEVQALIAEGI-ALVWESYKLDPY 830
Cdd:pfam08385  514 VRWYNKIRSTLlpVERP----LLAPHLKDIDEKLEPGLtTLTWNSLGIDEY 560
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4331-4642 3.36e-61

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 213.64  E-value: 3.36e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4331 TTQGVDMISKMLKMQMLEDEDdlayAETEKKTRTDstsdgrpawmrTLHTTASNWLHLIPQTL---SPLKRTVENIKDPL 4407
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSG----GGGGGSSREE-----------IVLELAKDILEKLPEPFdieEAEEKYPVGYEDPL 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4408 FRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQL 4487
Cdd:pfam18199   66 NTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4488 QNISQAaaaggakELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVT--ASQSTTLDACSFG--VTGLKL 4563
Cdd:pfam18199  146 QDWLDD-------EGPPKVFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTkkVSPEEVTEPPEDGvyVHGLFL 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4564 QGATCS--NNKL--SLSNAISTVLPLTQLRWGKQTSAEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVA 4639
Cdd:pfam18199  219 EGARWDrkNGCLveSEPKELFSPLPVIHLKPVESDKKKLDENTYECPVYKTSERHSTNFVFSVDLPTDKPPDHWILRGVA 298

                   ...
gi 148491097  4640 VLC 4642
Cdd:pfam18199  299 LLL 301
 
Name Accession Description Interval E-value
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1044-4327 0e+00

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1199.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1044 EVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSKWQALLVQIRRARGTFDNAETKKEF-GPVVIDYGKVQSKVNLKYDSWh 1122
Cdd:COG5245   170 SVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVATLDSLlSSSKYSELGRRLHFYANMDFS- 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1123 kevlskfGQMLGSNMTEFHSQISKSRQEL--EQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRF 1200
Cdd:COG5245   249 -------GIYFPKSFSEFKDSVISATQAVsrDIGRQSRMARRLILVQMDSLARLIVDRICEYVSIEWLGCCEELLTCSME 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1201 QFPPSWLYIDNIEgewgafNDIMRRKDSAIQQQvaNLQMKIVQEDRAVESRTTDLLTDWE-----KTKPVTGNLRPEEAL 1275
Cdd:COG5245   322 SMSSLVNSFDGEE------SEAMSLESSLFYEF--RGGEHLAGFYSAFGDIKRILLFTWSfkklgTLLPSLPGYSSGGMD 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1276 QALTIYEGKFGRLKDDREKCAKAKEALELTDTgllsgSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQpr 1355
Cdd:COG5245   394 YGEEYRSLLWELGSEVGDPDSGPVRKWMRKDL-----FDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTLEDDE-- 466
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1356 KLRQNLDGLLNQlknfpARLRQYASYEFVQRLlkgYMKINML------VIELKSEALKdrHWKQLMKrlhvnwvvseltl 1429
Cdd:COG5245   467 EDTPALAILLGQ-----EEAGRFVKLCKIMRM---FSFFNSLemfsrrTLANRMAIVK--YLSSVVR------------- 523
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1430 gqIWDVDLQKN-----EAIVKDVLLVAqgEMALEEFLKQIREVWNTYELDLVNYQNKC------RLIRGWddlfnkVKEH 1498
Cdd:COG5245   524 --TGPLFLQRDffgrmSELLMARDMFM--EVDGVLRLFFGGEWSGIVQLSGIRRAKRCverqidDEIREW------CSSV 593
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1499 INSVSAMKLSPYykvFEEDAlsweDKLNRIMALFDVWIdvqRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMK 1578
Cdd:COG5245   594 LSDDFLEERAVR---VERGA----DGARRLRASSGSPV---LRRLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYK 663
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1579 KVSKSPLVMDVLNIQgVQRSLERLADLLGKIQKALGEYLERERSSFPRFyfVGDEDLLEIIGNSKNVAKLQKHFKKMFAG 1658
Cdd:COG5245   664 RVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAK 740
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1659 VSSIILNEDSsvVLGISSREGEEVMFKTPVSITEHPKINEWLTlvEKEMRVtLAKLLaesvtevEIFGKATSIDPNTYIt 1738
Cdd:COG5245   741 EEMKTVFSSR--IQKKEPFSLDSEAYVGFFRLYEKSIVIRGIN--RSMGRV-LSQYL-------ESVQEALEIEDGSFF- 807
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1739 wIDKYQAQLVVLSAQIaWSENVENALSNvggggdvgPLQSVLSNVEVT----LNVLADSVLmeqpplrrRKLEHLITELV 1814
Cdd:COG5245   808 -VSRHRVRDGGLEKGR-GCDAWENCFDP--------PLSEYFRILEKIfpseEGYFFDEVL--------KRLDPGHEIKS 869
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1815 HQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMAnakfnYGFEYLGVQDKLVQTPLTDRCYLTMTQAL 1894
Cdd:COG5245   870 RIEEIIRMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSA-----EMFAKNTIPFFVFEHSMDTSQHQKLFEAV 944
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1895 EARLggSPFgpAGTGKTESVKALGHQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERMLsAVSQQVQ 1974
Cdd:COG5245   945 CDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR-TILVDEY 1010
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1975 CIQEALREHSNPNydktsapitcELLNKQVKVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTKPDRQLIAQvmlys 2054
Cdd:COG5245  1011 LNSDEFRMLEELN----------SAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGAIKSR----- 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2055 qgfrtAEVLANKIVPFFKLCDEQLSSQSHYDFglRALKSVLvsagnvkreriQKIKREKEERGEAVDEGEIAENLPeqei 2134
Cdd:COG5245  1072 -----RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-----------KAKHRMLEEKTEYLNKILSITGLP---- 1129
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2135 liqSVCETMVPklvaedipllfslLSDVFPGvqyhrgEMTALREelKKVCQEMYltygDGEEVGGMWVEKVLQLYQITQI 2214
Cdd:COG5245  1130 ---LISDTLRE-------------RIDTLDA------EWDSFCR--ISESLKKY----ESQQVSGLDVAQFVSFLRSVDT 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2215 NHGLMMVGPSGSGKSMAWRVLLKALerlegvegvAHIIDPKAIsKDHLYGTLdpntrEWTdGLFTHVLRkiiDNVRGELQ 2294
Cdd:COG5245  1182 GAFHAEYFRVFLCKIKHYTDACDYL---------WHVKSPYVK-KKYFDADM-----ELR-QFFLMFNR---EDMEARLA 1242
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2295 -KRQWIVFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRIMFEVQDlkyATLATVSRCGMVWFSEDVLSTDMIF 2373
Cdd:COG5245  1243 dSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVF 1307
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2374 NNFLARLRSiPLDEGEDEAQRRRKGKEDEGEeaaspmlqiqrdaatimqpyfTSNGLVTKALEHAFKLEHIMDLTRLRCL 2453
Cdd:COG5245  1308 LDELGDTKR-YLDECLDFFSCFEEVQKEIDE---------------------LSMVFCADALRFSADLYHIVKERRFSGV 1365
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2454 --GSLFSM-LHQACRNVAQyNANHPDfpmqieqLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRITTVPLPTAPN- 2529
Cdd:COG5245  1366 laGSDASEsLGGKSIELAA-ILEHKD-------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDLNERSDy 1437
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2530 --IPIIDYEVSISGE-WSPwqakVPQIEVETHKVAAP-DVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFS 2605
Cdd:COG5245  1438 eeMLIMMFNISAVITnNGS----IAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCP 1513
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2606 ALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMV 2685
Cdd:COG5245  1514 SLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLV 1593
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2686 EHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAE 2765
Cdd:COG5245  1594 ERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDEFNRLSE 1673
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2766 PLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTD 2845
Cdd:COG5245  1674 ETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSR 1753
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2846 ENIDMVALKHFPNIDKEKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFR 2925
Cdd:COG5245  1754 QDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLL 1833
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2926 QPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLER 3005
Cdd:COG5245  1834 VVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLED 1913
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3006 MNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFN 3085
Cdd:COG5245  1914 FNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKN 1993
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3086 RCVLNWFGDWSTEALYQVGKEFtskMDLEKPNYIVPDYMPVVydKLPQPPTHREAIVNSCVFVHQTLHQANARLAkrggr 3165
Cdd:COG5245  1994 RCFIDFKKLWDTEEMSQYANSV---ETLSRDGGRVFFINGEL--GVGKGALISEVFGDDAVVIEGRGFEISMIEG----- 2063
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3166 TMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQ 3245
Cdd:COG5245  2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGER 2143
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3246 QEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLL 3325
Cdd:COG5245  2144 LEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDL 2223
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3326 LGESTTDWKQIRSIIMRENFIPTIVNFSAE-EISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADML 3404
Cdd:COG5245  2224 LGFEAKIWFGEQQSLRRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3405 KRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAER 3484
Cdd:COG5245  2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3485 ERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTwSHHLQQANIQFRTDIART--EYLSNADERLRWQA 3562
Cdd:COG5245  2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEGVQKIEDFKEEA 2462
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3563 SSlpaDDLCTENA-IMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDP 3641
Cdd:COG5245  2463 CS---TDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDAEALDE 2539
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3642 VLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPD 3721
Cdd:COG5245  2540 EIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGP 2619
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3722 VDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLP 3801
Cdd:COG5245  2620 LFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNA 2699
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3802 LSTACSSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLyenpNLKGATDHTQRLSVITKDLFqvafnrvargMLHQDHITF 3881
Cdd:COG5245  2700 SVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR----RMKSKYLCAIRYMLMSSEWI----------LDHEDRSGF 2765
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3882 AMLLariklkgtmgeptydaEFQHFLRGKEIVLsagSTPKVQGLTVEQAEAVArlsclpAFKDLIakVQADEQFGiwLES 3961
Cdd:COG5245  2766 IHRL----------------DVSFLLRTKRFVS---TLLEDKNYRQVLSSCSL------YGNDVI--SHSCDRFD--RDV 2816
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3962 SSPEQTVPYLWTEETpatpigqaihRLLLIQAFRPDRLLAMAHMFVSTNLGEsFMSIMEqplDLTHIVGTEVKPNTPVLM 4041
Cdd:COG5245  2817 YRALKHQMDNRTHST----------ILTSNSKTNPYKEYTYNDSWAEAFEVE-DSGDLY---KFEEGLLELIVGHAPLIY 2882
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4042 CsvpgydasgHVEDLAAEQNTQitsiAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQL-----EKKLHSLQP 4116
Cdd:COG5245  2883 A---------HKKSLENERNVD----RLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYvedvvYPIKASRVC 2949
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4117 HACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVsrMCK-SPNERARLYFLLAWFHAVIQERLRYA 4195
Cdd:COG5245  2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDDAFYLSWEHAAVASVISAG 3027
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4196 PLGWSKKYEFGESDLRSACDTVDTWLddtAKGRQNispdKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTtrS 4275
Cdd:COG5245  3028 PKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLN----ARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGA--H 3098
                        3290      3300      3310      3320      3330
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148491097 4276 FDSEFKLACKVDGHKDIQ--MPDGIRREEFVQWVELLPDAQTPSWLGLPNNAER 4327
Cdd:COG5245  3099 ETSSQILASVPGGDPELVkfHMEEMCRSSAFGVIGQLPDLALCAWLMGPCDSEY 3152
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1866-2229 5.32e-171

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 529.75  E-value: 5.32e-171
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1866 YGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVG 1945
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1946 LCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNpnydktsapiTCELLNKQVKVSPDMAIFITMNPGYAGRSN 2025
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLK----------TFVFEGSEIKLNPSCGIFITMNPGYAGRTE 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2026 LPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRER 2105
Cdd:pfam12774  151 LPDNLKALFRPVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2106 iqkikrekeergeavdegeiaENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQ 2185
Cdd:pfam12774  231 ---------------------PNLNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCK 289
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 148491097  2186 EMYLTYGDgeevggMWVEKVLQLYQITQINHGLMMVGPSGSGKS 2229
Cdd:pfam12774  290 ELGLQPHD------AFILKVIQLYETMLVRHGVMLVGPTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
240-830 1.30e-142

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 458.58  E-value: 1.30e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   240 LNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTG 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   320 LKQALETVNDYNPLMKDF--PLNDLLSATELDKIRQALVAIFTHLRKI-RNTKY--PIQRALRLVEAISRDLSSQLLKVL 394
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   395 GTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKReenlkmvWRINPAHR-----KLQARLDQMRKFRR 469
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   470 QHEQLRAV--IVRVLRPQVTAVaqqnqgeapepqdmkVAEVlfdaadanaIEEVNLAYENVKEV--DGLDVSKEGteaWE 545
Cdd:pfam08385  234 TIEQFSKLekIGGTKGPELEGV---------------IEEI---------LEEFQEAYKVFKSKtyDILDVSNEG---FD 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   546 AAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQY 625
Cdd:pfam08385  287 DDYEEFKERIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQK 366
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   626 pqsQACKMSHvRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGweNHVEGQKLKQDGDSFRMKLN--TQEIFDDWARK 703
Cdd:pfam08385  367 ---YNPSPIA-KNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKE 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   704 VQQRNLGVSGR-IFTIESARVRgrsgnvlKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIES 782
Cdd:pfam08385  441 VEEASEGNLKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELL 513
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 148491097   783 VRTYERTCEKV--EERNtislLVAGLKKEVQALIAEGI-ALVWESYKLDPY 830
Cdd:pfam08385  514 VRWYNKIRSTLlpVERP----LLAPHLKDIDEKLEPGLtTLTWNSLGIDEY 560
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4331-4642 3.36e-61

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 213.64  E-value: 3.36e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4331 TTQGVDMISKMLKMQMLEDEDdlayAETEKKTRTDstsdgrpawmrTLHTTASNWLHLIPQTL---SPLKRTVENIKDPL 4407
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSG----GGGGGSSREE-----------IVLELAKDILEKLPEPFdieEAEEKYPVGYEDPL 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4408 FRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQL 4487
Cdd:pfam18199   66 NTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4488 QNISQAaaaggakELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVT--ASQSTTLDACSFG--VTGLKL 4563
Cdd:pfam18199  146 QDWLDD-------EGPPKVFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTkkVSPEEVTEPPEDGvyVHGLFL 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4564 QGATCS--NNKL--SLSNAISTVLPLTQLRWGKQTSAEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVA 4639
Cdd:pfam18199  219 EGARWDrkNGCLveSEPKELFSPLPVIHLKPVESDKKKLDENTYECPVYKTSERHSTNFVFSVDLPTDKPPDHWILRGVA 298

                   ...
gi 148491097  4640 VLC 4642
Cdd:pfam18199  299 LLL 301
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2568-2731 2.20e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 64.86  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2568 PTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRAL--PDMEVVGLNFSSATTPELLLKTFDHYCEYRRTpng 2645
Cdd:cd00009     1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrPGAPFLYLNASDLLEGLVVAELFGHFLVRLLF--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2646 vvlAPVQLGKWLVLFCDEIN-LPDMDKYGTQRVISFIRQMVEhggfyrtsdqtwvKLERIQFVGACNPPTDPG-RKPLSH 2723
Cdd:cd00009    78 ---ELAEKAKPGVLFIDEIDsLSRGAQNALLRVLETLNDLRI-------------DRENVRVIGATNRPLLGDlDRALYD 141

                  ....*...
gi 148491097 2724 RFLRHVPV 2731
Cdd:cd00009   142 RLDIRIVI 149
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3185-3498 2.43e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 2.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3185 FHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHK 3264
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLER 316
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3265 QQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHlVEVRSMANPPAAVKLALESIcllLGESTTDWKQIRSIImren 3344
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEEL-ESLEAELEELEAELEELESR---LEELEEQLETLRSKV---- 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3345 fiptivnfsaeeisDAIREKMKKNymsnpsyNYEIVNRASLacgpmvkwaIAQLNyadmlKRVEPLRNELQKLEDDAKDN 3424
Cdd:TIGR02168  389 --------------AQLELQIASL-------NNEIERLEAR---------LERLE-----DRRERLQQEIEELLKKLEEA 433
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148491097  3425 QQKA-----NEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQM 3498
Cdd:TIGR02168  434 ELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALL 512
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
2586-2735 2.37e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 2.37e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   2586 HKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNG-------VVLAPVQLGKWLV 2658
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlrLALALARKLKPDV 81
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148491097   2659 LFCDEINLpdMDKYGTQRVISFIRQMVEHGGFYRTsdqtwvklERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVD 2735
Cdd:smart00382   82 LILDEITS--LLDAEQEALLLLLEELRLLLLLKSE--------KNLTVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
mukB PRK04863
chromosome partition protein MukB;
3187-3559 2.62e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3187 EKRSELEEQQMHLNvglrkikETVDQVEELRRDLRIKSQELEvknaAANDKLKKMVKD--QQEAEKKKVMS-QEIQEQLH 3263
Cdd:PRK04863  297 TSRRQLAAEQYRLV-------EMARELAELNEAESDLEQDYQ----AASDHLNLVQTAlrQQEKIERYQADlEELEERLE 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3264 KQQEVIADKQmsvkEDLDKVEPAVIEAQNAVKSIKKQ------HLVEVRSMANPPAAVKLALESICLLLGESTTDWkqir 3337
Cdd:PRK04863  366 EQNEVVEEAD----EQQEENEARAEAAEEEVDELKSQladyqqALDVQQTRAIQYQQAVQALERAKQLCGLPDLTA---- 437
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3338 siimrENFIPTIVNFSAEE---------------ISDAIREKMKKNYMSNPSYNYEIV-NRASlacgpmvKWAIAQLNYA 3401
Cdd:PRK04863  438 -----DNAEDWLEEFQAKEqeateellsleqklsVAQAAHSQFEQAYQLVRKIAGEVSrSEAW-------DVARELLRRL 505
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3402 DMLK----RVEPLRNELQKLEDDAKdNQQKAN------------------EVEQMIRDLEASIARYKEEYAVLISEAQAI 3459
Cdd:PRK04863  506 REQRhlaeQLQQLRMRLSELEQRLR-QQQRAErllaefckrlgknlddedELEQLQEELEARLESLSESVSEARERRMAL 584
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3460 KADLAAVEAKVNRstallksLSAERERWEKTSETFkNQMSTIAGDCLLSAAFIayagyfDQQMRQNLFTTWShhLQQANI 3539
Cdd:PRK04863  585 RQQLEQLQARIQR-------LAARAPAWLAAQDAL-ARLREQSGEEFEDSQDV------TEYMQQLLERERE--LTVERD 648
                         410       420
                  ....*....|....*....|....*...
gi 148491097 3540 QFRTDI----ARTEYLSNA----DERLR 3559
Cdd:PRK04863  649 ELAARKqaldEEIERLSQPggseDPRLN 676
 
Name Accession Description Interval E-value
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1044-4327 0e+00

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 1199.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1044 EVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSKWQALLVQIRRARGTFDNAETKKEF-GPVVIDYGKVQSKVNLKYDSWh 1122
Cdd:COG5245   170 SVCSERDGFYEEKSFWSRFHMEMCHIREFCRSKAFRFACDVLRKSGKYVTVATLDSLlSSSKYSELGRRLHFYANMDFS- 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1123 kevlskfGQMLGSNMTEFHSQISKSRQEL--EQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRF 1200
Cdd:COG5245   249 -------GIYFPKSFSEFKDSVISATQAVsrDIGRQSRMARRLILVQMDSLARLIVDRICEYVSIEWLGCCEELLTCSME 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1201 QFPPSWLYIDNIEgewgafNDIMRRKDSAIQQQvaNLQMKIVQEDRAVESRTTDLLTDWE-----KTKPVTGNLRPEEAL 1275
Cdd:COG5245   322 SMSSLVNSFDGEE------SEAMSLESSLFYEF--RGGEHLAGFYSAFGDIKRILLFTWSfkklgTLLPSLPGYSSGGMD 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1276 QALTIYEGKFGRLKDDREKCAKAKEALELTDTgllsgSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQpr 1355
Cdd:COG5245   394 YGEEYRSLLWELGSEVGDPDSGPVRKWMRKDL-----FDAKVRSGVSFGKQEEFVSDIFNITFERIHGMDPTTLEDDE-- 466
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1356 KLRQNLDGLLNQlknfpARLRQYASYEFVQRLlkgYMKINML------VIELKSEALKdrHWKQLMKrlhvnwvvseltl 1429
Cdd:COG5245   467 EDTPALAILLGQ-----EEAGRFVKLCKIMRM---FSFFNSLemfsrrTLANRMAIVK--YLSSVVR------------- 523
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1430 gqIWDVDLQKN-----EAIVKDVLLVAqgEMALEEFLKQIREVWNTYELDLVNYQNKC------RLIRGWddlfnkVKEH 1498
Cdd:COG5245   524 --TGPLFLQRDffgrmSELLMARDMFM--EVDGVLRLFFGGEWSGIVQLSGIRRAKRCverqidDEIREW------CSSV 593
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1499 INSVSAMKLSPYykvFEEDAlsweDKLNRIMALFDVWIdvqRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMK 1578
Cdd:COG5245   594 LSDDFLEERAVR---VERGA----DGARRLRASSGSPV---LRRLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYK 663
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1579 KVSKSPLVMDVLNIQgVQRSLERLADLLGKIQKALGEYLERERSSFPRFyfVGDEDLLEIIGNSKNVAKLQKHFKKMFAG 1658
Cdd:COG5245   664 RVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAK 740
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1659 VSSIILNEDSsvVLGISSREGEEVMFKTPVSITEHPKINEWLTlvEKEMRVtLAKLLaesvtevEIFGKATSIDPNTYIt 1738
Cdd:COG5245   741 EEMKTVFSSR--IQKKEPFSLDSEAYVGFFRLYEKSIVIRGIN--RSMGRV-LSQYL-------ESVQEALEIEDGSFF- 807
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1739 wIDKYQAQLVVLSAQIaWSENVENALSNvggggdvgPLQSVLSNVEVT----LNVLADSVLmeqpplrrRKLEHLITELV 1814
Cdd:COG5245   808 -VSRHRVRDGGLEKGR-GCDAWENCFDP--------PLSEYFRILEKIfpseEGYFFDEVL--------KRLDPGHEIKS 869
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1815 HQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMAnakfnYGFEYLGVQDKLVQTPLTDRCYLTMTQAL 1894
Cdd:COG5245   870 RIEEIIRMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSA-----EMFAKNTIPFFVFEHSMDTSQHQKLFEAV 944
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1895 EARLggSPFgpAGTGKTESVKALGHQLGRFVlvfncdETFDFQAmgRIFVGLCQVGAWGcFDEFNRLEERMLsAVSQQVQ 1974
Cdd:COG5245   945 CDEV--CRF--VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEERG-TEESALLDEISR-TILVDEY 1010
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 1975 CIQEALREHSNPNydktsapitcELLNKQVKVSPDMAIFITMNPgyagRSNLPDNLKKLFRSLAMTKPDRQLIAQvmlys 2054
Cdd:COG5245  1011 LNSDEFRMLEELN----------SAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNIPFGAIKSR----- 1071
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2055 qgfrtAEVLANKIVPFFKLCDEQLSSQSHYDFglRALKSVLvsagnvkreriQKIKREKEERGEAVDEGEIAENLPeqei 2134
Cdd:COG5245  1072 -----RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSL-----------KAKHRMLEEKTEYLNKILSITGLP---- 1129
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2135 liqSVCETMVPklvaedipllfslLSDVFPGvqyhrgEMTALREelKKVCQEMYltygDGEEVGGMWVEKVLQLYQITQI 2214
Cdd:COG5245  1130 ---LISDTLRE-------------RIDTLDA------EWDSFCR--ISESLKKY----ESQQVSGLDVAQFVSFLRSVDT 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2215 NHGLMMVGPSGSGKSMAWRVLLKALerlegvegvAHIIDPKAIsKDHLYGTLdpntrEWTdGLFTHVLRkiiDNVRGELQ 2294
Cdd:COG5245  1182 GAFHAEYFRVFLCKIKHYTDACDYL---------WHVKSPYVK-KKYFDADM-----ELR-QFFLMFNR---EDMEARLA 1242
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2295 -KRQWIVFDgdvdpEWVENLNSVLDDNKLLTLPNGERlslppnvRIMFEVQDlkyATLATVSRCGMVWFSEDVLSTDMIF 2373
Cdd:COG5245  1243 dSKMEYEVE-----RYVEKTKAEVSSLKLELSSVGEG-------QVVVSNLG---SIGDKVGRCLVEYDSISRLSTKGVF 1307
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2374 NNFLARLRSiPLDEGEDEAQRRRKGKEDEGEeaaspmlqiqrdaatimqpyfTSNGLVTKALEHAFKLEHIMDLTRLRCL 2453
Cdd:COG5245  1308 LDELGDTKR-YLDECLDFFSCFEEVQKEIDE---------------------LSMVFCADALRFSADLYHIVKERRFSGV 1365
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2454 --GSLFSM-LHQACRNVAQyNANHPDfpmqieqLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRRITTVPLPTAPN- 2529
Cdd:COG5245  1366 laGSDASEsLGGKSIELAA-ILEHKD-------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDLNERSDy 1437
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2530 --IPIIDYEVSISGE-WSPwqakVPQIEVETHKVAAP-DVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFS 2605
Cdd:COG5245  1438 eeMLIMMFNISAVITnNGS----IAGFELRGERVMLRkEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCP 1513
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2606 ALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMV 2685
Cdd:COG5245  1514 SLRSELITEVKYFNFSTCTMTPSKLSVLERETEYYPNTGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLV 1593
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2686 EHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAE 2765
Cdd:COG5245  1594 ERQGFWSSIAVSWVTICGIILYGACNPGTDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGSYLCFDEFNRLSE 1673
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2766 PLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTD 2845
Cdd:COG5245  1674 ETMSASVELYLSSKDKTKFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSR 1753
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2846 ENIDMVALKHFPNIDKEKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFR 2925
Cdd:COG5245  1754 QDLYDFGLRAIREMIAGHIGEAEITFSMILFFGMACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLL 1833
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2926 QPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLER 3005
Cdd:COG5245  1834 VVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLED 1913
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3006 MNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFN 3085
Cdd:COG5245  1914 FNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLEKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKN 1993
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3086 RCVLNWFGDWSTEALYQVGKEFtskMDLEKPNYIVPDYMPVVydKLPQPPTHREAIVNSCVFVHQTLHQANARLAkrggr 3165
Cdd:COG5245  1994 RCFIDFKKLWDTEEMSQYANSV---ETLSRDGGRVFFINGEL--GVGKGALISEVFGDDAVVIEGRGFEISMIEG----- 2063
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3166 TMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQ 3245
Cdd:COG5245  2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGER 2143
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3246 QEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLL 3325
Cdd:COG5245  2144 LEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDL 2223
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3326 LGESTTDWKQIRSIIMRENFIPTIVNFSAE-EISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADML 3404
Cdd:COG5245  2224 LGFEAKIWFGEQQSLRRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3405 KRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAER 3484
Cdd:COG5245  2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3485 ERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTwSHHLQQANIQFRTDIART--EYLSNADERLRWQA 3562
Cdd:COG5245  2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGM-SFIRISKEFRDKEIRRRQfiTEGVQKIEDFKEEA 2462
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3563 SSlpaDDLCTENA-IMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDP 3641
Cdd:COG5245  2463 CS---TDYGLENSrIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGDAEALDE 2539
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3642 VLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPD 3721
Cdd:COG5245  2540 EIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGP 2619
                        2730      2740      2750      2760      2770      2780      2790      2800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3722 VDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLP 3801
Cdd:COG5245  2620 LFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNA 2699
                        2810      2820      2830      2840      2850      2860      2870      2880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3802 LSTACSSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLyenpNLKGATDHTQRLSVITKDLFqvafnrvargMLHQDHITF 3881
Cdd:COG5245  2700 SVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR----RMKSKYLCAIRYMLMSSEWI----------LDHEDRSGF 2765
                        2890      2900      2910      2920      2930      2940      2950      2960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3882 AMLLariklkgtmgeptydaEFQHFLRGKEIVLsagSTPKVQGLTVEQAEAVArlsclpAFKDLIakVQADEQFGiwLES 3961
Cdd:COG5245  2766 IHRL----------------DVSFLLRTKRFVS---TLLEDKNYRQVLSSCSL------YGNDVI--SHSCDRFD--RDV 2816
                        2970      2980      2990      3000      3010      3020      3030      3040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3962 SSPEQTVPYLWTEETpatpigqaihRLLLIQAFRPDRLLAMAHMFVSTNLGEsFMSIMEqplDLTHIVGTEVKPNTPVLM 4041
Cdd:COG5245  2817 YRALKHQMDNRTHST----------ILTSNSKTNPYKEYTYNDSWAEAFEVE-DSGDLY---KFEEGLLELIVGHAPLIY 2882
                        3050      3060      3070      3080      3090      3100      3110      3120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4042 CsvpgydasgHVEDLAAEQNTQitsiAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQL-----EKKLHSLQP 4116
Cdd:COG5245  2883 A---------HKKSLENERNVD----RLGSKENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYvedvvYPIKASRVC 2949
                        3130      3140      3150      3160      3170      3180      3190      3200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4117 HACFRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVsrMCK-SPNERARLYFLLAWFHAVIQERLRYA 4195
Cdd:COG5245  2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDRY--PFDyTLVIACDDAFYLSWEHAAVASVISAG 3027
                        3210      3220      3230      3240      3250      3260      3270      3280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 4196 PLGWSKKYEFGESDLRSACDTVDTWLddtAKGRQNispdKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTtrS 4275
Cdd:COG5245  3028 PKENNEEIYFGDKDFEFKTHLLKNIL---FLNHLN----ARKWGNNRDLIFTIVYGKKHSLMEDSKVVDKYCRGYGA--H 3098
                        3290      3300      3310      3320      3330
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148491097 4276 FDSEFKLACKVDGHKDIQ--MPDGIRREEFVQWVELLPDAQTPSWLGLPNNAER 4327
Cdd:COG5245  3099 ETSSQILASVPGGDPELVkfHMEEMCRSSAFGVIGQLPDLALCAWLMGPCDSEY 3152
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1866-2229 5.32e-171

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 529.75  E-value: 5.32e-171
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1866 YGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVG 1945
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1946 LCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNpnydktsapiTCELLNKQVKVSPDMAIFITMNPGYAGRSN 2025
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLK----------TFVFEGSEIKLNPSCGIFITMNPGYAGRTE 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2026 LPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRER 2105
Cdd:pfam12774  151 LPDNLKALFRPVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2106 iqkikrekeergeavdegeiaENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQ 2185
Cdd:pfam12774  231 ---------------------PNLNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCK 289
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 148491097  2186 EMYLTYGDgeevggMWVEKVLQLYQITQINHGLMMVGPSGSGKS 2229
Cdd:pfam12774  290 ELGLQPHD------AFILKVIQLYETMLVRHGVMLVGPTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
240-830 1.30e-142

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 458.58  E-value: 1.30e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   240 LNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTG 319
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDSQGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFKALDTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   320 LKQALETVNDYNPLMKDF--PLNDLLSATELDKIRQALVAIFTHLRKI-RNTKY--PIQRALRLVEAISRDLSSQLLKVL 394
Cdd:pfam08385   81 LTDALNEAKDNVKYLKTLerPFEDLEELTDPPEIIEAIPPLMNTIRLIwSISRYynTSERMTVLLEKISNQLIEQCKKYL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   395 GTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKReenlkmvWRINPAHR-----KLQARLDQMRKFRR 469
Cdd:pfam08385  161 SPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRERP-------WDFSERYIfgrfdAFLERLEKILELFE 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   470 QHEQLRAV--IVRVLRPQVTAVaqqnqgeapepqdmkVAEVlfdaadanaIEEVNLAYENVKEV--DGLDVSKEGteaWE 545
Cdd:pfam08385  234 TIEQFSKLekIGGTKGPELEGV---------------IEEI---------LEEFQEAYKVFKSKtyDILDVSNEG---FD 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   546 AAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQY 625
Cdd:pfam08385  287 DDYEEFKERIKDLERRLQAFIDQAFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQK 366
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   626 pqsQACKMSHvRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGweNHVEGQKLKQDGDSFRMKLN--TQEIFDDWARK 703
Cdd:pfam08385  367 ---YNPSPIA-KNMPPVAGAIIWARQLFRRIQEPMKRFKEELGLL--KHAEGKKVIKKYNELAKKLDeyERLIYEAWLKE 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   704 VQQRNLGVSGR-IFTIESARVRgrsgnvlKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIES 782
Cdd:pfam08385  441 VEEASEGNLKRpLLVRHPETGK-------LLSVNFDPQLLALLREVKYLQKLGFEIPESALNIALKEERLRPYAESLELL 513
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 148491097   783 VRTYERTCEKV--EERNtislLVAGLKKEVQALIAEGI-ALVWESYKLDPY 830
Cdd:pfam08385  514 VRWYNKIRSTLlpVERP----LLAPHLKDIDEKLEPGLtTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1317-1718 2.13e-142

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 451.33  E-value: 2.13e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1317 VQVALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDGLLNQLKNFPARLRQYASYEFVQRLLKGYMKINM 1396
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1397 LVIELKSEALKDRHWKQLMKRLHVNW--VVSELTLGQIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELD 1474
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFdpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1475 LVNYQN-KCRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSa 1553
Cdd:pfam08393  161 LVPYKDtGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFSSE- 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1554 DIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDE 1633
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  1634 DLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDSSVVlGISSREGEEVMFKTPVSITEhPKINEWLTLVEKEMRVTLAK 1713
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEIT-GMISKEGEVVPFSKPPVEAK-GNVEEWLNELEEEMRETLRD 397

                   ....*
gi 148491097  1714 LLAES 1718
Cdd:pfam08393  398 LLKEA 402
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3558-3778 2.20e-99

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 319.77  E-value: 2.20e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3558 LRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDV- 3636
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVg 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3637 ESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLK 3716
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148491097  3717 AERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV 3778
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2906-3184 3.81e-70

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 237.51  E-value: 3.81e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2906 PLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKN 2985
Cdd:pfam12780    2 DLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIKG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2986 EKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLmLDSHEELYKWFTSQVIRNLHVVFT 3065
Cdd:pfam12780   82 KPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNI-EDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3066 MNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKpnyivpdympvvydklpqppTHREAIVNSC 3145
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE--------------------ELKSNVVKVF 220
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 148491097  3146 VFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANL 3184
Cdd:pfam12780  221 VYVHSSVEDMSKKFYEELKRKNYVTPKSYLELLRLYKNL 259
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4331-4642 3.36e-61

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 213.64  E-value: 3.36e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4331 TTQGVDMISKMLKMQMLEDEDdlayAETEKKTRTDstsdgrpawmrTLHTTASNWLHLIPQTL---SPLKRTVENIKDPL 4407
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSG----GGGGGSSREE-----------IVLELAKDILEKLPEPFdieEAEEKYPVGYEDPL 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4408 FRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQL 4487
Cdd:pfam18199   66 NTVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4488 QNISQAaaaggakELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVT--ASQSTTLDACSFG--VTGLKL 4563
Cdd:pfam18199  146 QDWLDD-------EGPPKVFWLSGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTkkVSPEEVTEPPEDGvyVHGLFL 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4564 QGATCS--NNKL--SLSNAISTVLPLTQLRWGKQTSAEKKASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVA 4639
Cdd:pfam18199  219 EGARWDrkNGCLveSEPKELFSPLPVIHLKPVESDKKKLDENTYECPVYKTSERHSTNFVFSVDLPTDKPPDHWILRGVA 298

                   ...
gi 148491097  4640 VLC 4642
Cdd:pfam18199  299 LLL 301
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
4174-4325 6.50e-56

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 191.90  E-value: 6.50e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4174 RARLYFLLAWFHAVIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDtakgrqniSPDKIPWSALKTLMAQSIYGGR 4253
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDE--------YDEKIPWDALRYLIGEINYGGR 72
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148491097  4254 VDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVdghkdIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNA 4325
Cdd:pfam18198   73 VTDDWDRRLLNTYLEEFFNPEVLEEDFKFSPSL-----YYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
3199-3534 5.20e-45

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 168.33  E-value: 5.20e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3199 LNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAAnDKLKKMVK-DQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVK 3277
Cdd:pfam12777    3 LENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDA-DKLIQVVGiEADKVSKEKAIADEEEQKVAVIMKEVKEKQKACE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3278 EDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLL---GESTTD--WKQIRSIIMR-ENFIPTIVN 3351
Cdd:pfam12777   82 EDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMapgGKIPKDksWKAAKIMMAKvDGFLDSLIK 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3352 FSAEEISDAIREKMKKnYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQQKANEV 3431
Cdd:pfam12777  162 FDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAAI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3432 EQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAF 3511
Cdd:pfam12777  241 KAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISAF 320
                          330       340
                   ....*....|....*....|....
gi 148491097  3512 IAYAGYFDQQMRQNLF-TTWSHHL 3534
Cdd:pfam12777  321 ISYLGFFTKKYRNELLdKFWIPYI 344
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2564-2728 6.76e-45

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 161.79  E-value: 6.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2564 DVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALP--DMEVVGLNFSSATTPELLLKTFDHYCEYRR 2641
Cdd:pfam12775    9 EILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkeKYLPLFINFSAQTTSNQTQDIIESKLEKRR 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2642 tpnGVVLAPVqLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTdPGRKPL 2721
Cdd:pfam12775   89 ---KGVYGPP-GGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPG-GGRNDI 163

                   ....*..
gi 148491097  2722 SHRFLRH 2728
Cdd:pfam12775  164 TPRLLRH 170
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
4034-4144 9.34e-37

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 136.04  E-value: 9.34e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  4034 KPNTPVLMCSVPGYDASGHVEDLAAEQN--TQITSIAIGSAEGFnQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKL 4111
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGfgGKLHSISLGQGQGP-IAEKLIEEAAKEGGWVLLQNCHLALSWMPELEKIL 79
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 148491097  4112 HSLQ---PHACFRLFLTMEINPKVPVNLLRAGRIFV 4144
Cdd:pfam03028   80 EELPeetLHPDFRLWLTSEPSPKFPISILQNSIKIT 115
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2421-2547 1.15e-23

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 99.28  E-value: 1.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2421 MQPYFtsNGLVTKALEHAFK-LEHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPdfpMQIEQLERYIQRYLVYAILWS 2499
Cdd:pfam17852    1 LEPLF--EWLVPPALEFVRKnCKEIVPTSDLNLVQSLCRLLESLLDEVLEYNGVHP---LSPDKLKEYLEKLFLFALVWS 75
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 148491097  2500 LSGDSRLKMRAELGEYIRRITT-VPLPTAPNIPIIDYEVSI-SGEWSPWQ 2547
Cdd:pfam17852   76 IGGTLDEDSRKKFDEFLRELFSgLDLPPPEKGTVYDYFVDLeKGEWVPWS 125
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2217-2357 8.67e-15

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 74.25  E-value: 8.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2217 GLMMVGPSGSGKSMAWRVLLKALERLEGVEGVAHiidpKAISKDHLYGTLDPNTR--EWTDGLFTHVLRKiidnvrgelq 2294
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLT----RDTTEEDLFGRRNIDPGgaSWVDGPLVRAARE---------- 66
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491097  2295 krQWIVFDGDVD---PEWVENLNSVLDDNKLLTLPNGERLSLPP-NVRIMFEV----QDLKYATLATVSRC 2357
Cdd:pfam07728   67 --GEIAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIATMnpldRGLNELSPALRSRF 135
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2568-2731 2.20e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 64.86  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2568 PTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRAL--PDMEVVGLNFSSATTPELLLKTFDHYCEYRRTpng 2645
Cdd:cd00009     1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrPGAPFLYLNASDLLEGLVVAELFGHFLVRLLF--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2646 vvlAPVQLGKWLVLFCDEIN-LPDMDKYGTQRVISFIRQMVEhggfyrtsdqtwvKLERIQFVGACNPPTDPG-RKPLSH 2723
Cdd:cd00009    78 ---ELAEKAKPGVLFIDEIDsLSRGAQNALLRVLETLNDLRI-------------DRENVRVIGATNRPLLGDlDRALYD 141

                  ....*...
gi 148491097 2724 RFLRHVPV 2731
Cdd:cd00009   142 RLDIRIVI 149
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3185-3498 2.43e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 2.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3185 FHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHK 3264
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLER 316
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3265 QQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHlVEVRSMANPPAAVKLALESIcllLGESTTDWKQIRSIImren 3344
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEEL-ESLEAELEELEAELEELESR---LEELEEQLETLRSKV---- 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3345 fiptivnfsaeeisDAIREKMKKNymsnpsyNYEIVNRASLacgpmvkwaIAQLNyadmlKRVEPLRNELQKLEDDAKDN 3424
Cdd:TIGR02168  389 --------------AQLELQIASL-------NNEIERLEAR---------LERLE-----DRRERLQQEIEELLKKLEEA 433
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148491097  3425 QQKA-----NEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQM 3498
Cdd:TIGR02168  434 ELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALL 512
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3172-3515 6.52e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 6.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3172 RHYLDFINHYANLF--HEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKK----MVKDQ 3245
Cdd:COG4717   115 REELEKLEKLLQLLplYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQlslaTEEEL 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3246 QEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAViEAQNAVKSIKKQHLV----------------EVRSMA 3309
Cdd:COG4717   195 QDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL-EAAALEERLKEARLLlliaaallallglggsLLSLIL 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3310 NPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIvnfsaEEISDAIREKMKKNYMSNPSYNYEIVNRASLAcgp 3389
Cdd:COG4717   274 TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPAL-----EELEEEELEELLAALGLPPDLSPEELLELLDR--- 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3390 MVKWAIAQLNYADMLKR--VEPLRNELQKLEDDAK-----------DNQQKANEVEQMIRDLEASIARYKEEyavliSEA 3456
Cdd:COG4717   346 IEELQELLREAEELEEElqLEELEQEIAALLAEAGvedeeelraalEQAEEYQELKEELEELEEQLEELLGE-----LEE 420
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148491097 3457 QAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYA 3515
Cdd:COG4717   421 LLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELE 479
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
2586-2735 2.37e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.45  E-value: 2.37e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   2586 HKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNG-------VVLAPVQLGKWLV 2658
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlrLALALARKLKPDV 81
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148491097   2659 LFCDEINLpdMDKYGTQRVISFIRQMVEHGGFYRTsdqtwvklERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVD 2735
Cdd:smart00382   82 LILDEITS--LLDAEQEALLLLLEELRLLLLLKSE--------KNLTVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2920-3010 1.80e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 47.91  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 2920 IDRIFRQPQGHLLLIGVSGAGKTTLSRFVAW---MNGLSVYQIKVHRKYTGEDFDEDLRTVLRRS----GCKNEKIAFIM 2992
Cdd:cd00009    11 REALELPPPKNLLLYGPPGTGKTTLARAIANelfRPGAPFLYLNASDLLEGLVVAELFGHFLVRLlfelAEKAKPGVLFI 90
                          90
                  ....*....|....*...
gi 148491097 2993 DESNVLDSGFLERMNTLL 3010
Cdd:cd00009    91 DEIDSLSRGAQNALLRVL 108
mukB PRK04863
chromosome partition protein MukB;
3187-3559 2.62e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3187 EKRSELEEQQMHLNvglrkikETVDQVEELRRDLRIKSQELEvknaAANDKLKKMVKD--QQEAEKKKVMS-QEIQEQLH 3263
Cdd:PRK04863  297 TSRRQLAAEQYRLV-------EMARELAELNEAESDLEQDYQ----AASDHLNLVQTAlrQQEKIERYQADlEELEERLE 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3264 KQQEVIADKQmsvkEDLDKVEPAVIEAQNAVKSIKKQ------HLVEVRSMANPPAAVKLALESICLLLGESTTDWkqir 3337
Cdd:PRK04863  366 EQNEVVEEAD----EQQEENEARAEAAEEEVDELKSQladyqqALDVQQTRAIQYQQAVQALERAKQLCGLPDLTA---- 437
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3338 siimrENFIPTIVNFSAEE---------------ISDAIREKMKKNYMSNPSYNYEIV-NRASlacgpmvKWAIAQLNYA 3401
Cdd:PRK04863  438 -----DNAEDWLEEFQAKEqeateellsleqklsVAQAAHSQFEQAYQLVRKIAGEVSrSEAW-------DVARELLRRL 505
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3402 DMLK----RVEPLRNELQKLEDDAKdNQQKAN------------------EVEQMIRDLEASIARYKEEYAVLISEAQAI 3459
Cdd:PRK04863  506 REQRhlaeQLQQLRMRLSELEQRLR-QQQRAErllaefckrlgknlddedELEQLQEELEARLESLSESVSEARERRMAL 584
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3460 KADLAAVEAKVNRstallksLSAERERWEKTSETFkNQMSTIAGDCLLSAAFIayagyfDQQMRQNLFTTWShhLQQANI 3539
Cdd:PRK04863  585 RQQLEQLQARIQR-------LAARAPAWLAAQDAL-ARLREQSGEEFEDSQDV------TEYMQQLLERERE--LTVERD 648
                         410       420
                  ....*....|....*....|....*...
gi 148491097 3540 QFRTDI----ARTEYLSNA----DERLR 3559
Cdd:PRK04863  649 ELAARKqaldEEIERLSQPggseDPRLN 676
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2588-2727 9.63e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.36  E-value: 9.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2588 PLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKwlVLFCDEINLP 2667
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRNIDPGGASWVDGPLVRAAREGE--IAVLDEINRA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491097  2668 DMDKYGTQ-RVISFIRQMVEHGGFYRTsdqtwVKLERIQFVGACNPPtDPGRKPLSHRFLR 2727
Cdd:pfam07728   79 NPDVLNSLlSLLDERRLLLPDGGELVK-----AAPDGFRLIATMNPL-DRGLNELSPALRS 133
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
3232-3486 1.03e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3232 AAANDKLKKMVKDQQEAEKKKvmsQEIQEQLHKQQEVIADKQmsvkEDLDKVEPAVIEAQNAVKSIKKQhLVEVRsmanp 3311
Cdd:COG3883    12 AFADPQIQAKQKELSELQAEL---EAAQAELDALQAELEELN----EEYNELQAELEALQAEIDKLQAE-IAEAE----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3312 pAAVKLALEsiclLLGesttdwKQIRSIIMRENFIPTI-VNFSAEEISDAIrekmkknymsnpsynyeivNRASlacgpm 3390
Cdd:COG3883    79 -AEIEERRE----ELG------ERARALYRSGGSVSYLdVLLGSESFSDFL-------------------DRLS------ 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3391 vkwAIAQLNYADmLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASiaryKEEYAVLISEAQAIKADLAAVEAKV 3470
Cdd:COG3883   123 ---ALSKIADAD-ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA----KAELEAQQAEQEALLAQLSAEEAAA 194
                         250
                  ....*....|....*.
gi 148491097 3471 NRSTALLKSLSAERER 3486
Cdd:COG3883   195 EAQLAELEAELAAAEA 210
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
3187-3488 2.89e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3187 EKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAA---ANDKLKKMVKDQQEAEKKKVMSQEIQEQLH 3263
Cdd:COG1196   243 ELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEeyeLLAELARLEQDIARLEERRRELEERLEELE 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3264 KQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHlvevrsmanppAAVKLALESICLLLGESTTDWKQIRSIIMRE 3343
Cdd:COG1196   323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAEL-----------AEAEEALLEAEAELAEAEEELEELAEELLEA 391
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3344 nfIPTIVNFSAEEISDAIREkmkknymsnpsynyeivnraslacgpmvkwAIAQLNYADMLKRVEPLRNELQKLEDDAKD 3423
Cdd:COG1196   392 --LRAAAELAAQLEELEEAE------------------------------EALLERLERLEEELEELEEALAELEEEEEE 439
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148491097 3424 NQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWE 3488
Cdd:COG1196   440 EEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3187-3483 3.64e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.98  E-value: 3.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3187 EKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEvknaaandklkkmvKDQQEAEKKKVMSQEIQEQLHKQQ 3266
Cdd:TIGR02169  681 ERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIE--------------KEIEQLEQEEEKLKERLEELEEDL 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3267 EVIADKQMSVKEDLDKVEpAVIEAQNAVKsikkqhlvevrsmanppAAVKLALESICLLLGESttDWKQIRSIImreNFI 3346
Cdd:TIGR02169  747 SSLEQEIENVKSELKELE-ARIEELEEDL-----------------HKLEEALNDLEARLSHS--RIPEIQAEL---SKL 803
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3347 PTIVNfSAEEISDAI-----REKMKKNYMSNPSYNYEIVNRAslacgpmvkwaiAQLNYADMLKRVEPLRNELQKLEDDA 3421
Cdd:TIGR02169  804 EEEVS-RIEARLREIeqklnRLTLEKEYLEKEIQELQEQRID------------LKEQIKSIEKEIENLNGKKEELEEEL 870
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148491097  3422 KDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAE 3483
Cdd:TIGR02169  871 EELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEE 932
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
3400-3483 3.75e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3400 YADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVN-RSTALLK 3478
Cdd:COG1579    91 YEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEaEREELAA 170

                  ....*
gi 148491097 3479 SLSAE 3483
Cdd:COG1579   171 KIPPE 175
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2930-3087 4.97e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 43.05  E-value: 4.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2930 HLLLIGVSGAGKTTLS-RFVAWMNGLSVYQIKVHRKYTGEDF----------DEDLRTVLRRSGcKNEKIAFImDESNVL 2998
Cdd:pfam07728    1 GVLLVGPPGTGKTELAeRLAAALSNRPVFYVQLTRDTTEEDLfgrrnidpggASWVDGPLVRAA-REGEIAVL-DEINRA 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  2999 DSGFLERMNTLLANGEVPgLFEGDEYAtlmtqckegaqkeglmldsHEELYkwftsqvirNLHVVFTMNPSSEGLKDraa 3078
Cdd:pfam07728   79 NPDVLNSLLSLLDERRLL-LPDGGELV-------------------KAAPD---------GFRLIATMNPLDRGLNE--- 126

                   ....*....
gi 148491097  3079 TSPALFNRC 3087
Cdd:pfam07728  127 LSPALRSRF 135
AIP3 smart00806
Actin interacting protein 3; Aip3p/Bud6p is a regulator of cell and cytoskeletal polarity in ...
3189-3321 1.50e-03

Actin interacting protein 3; Aip3p/Bud6p is a regulator of cell and cytoskeletal polarity in Saccharomyces cerevisiae that was previously identified as an actin-interacting protein. Actin-interacting protein 3 (Aip3p) localizes at the cell cortex where cytoskeleton assembly must be achieved to execute polarized cell growth, and deletion of AIP3 causes gross defects in cell and cytoskeletal polarity. Aip3p localization is mediated by the secretory pathway, mutations in early- or late-acting components of the secretory apparatus lead to Aip3p mislocalization.


Pssm-ID: 214826 [Multi-domain]  Cd Length: 426  Bit Score: 44.66  E-value: 1.50e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   3189 RSELEEQQMHLnvgLRKIKETVDQVEELRRDL-----RIKSQELEVKN---AAANDKLKKMV----------KDQQEAEK 3250
Cdd:smart00806  212 KKKLSEDSDSL---LTKVDDLQDIIEALRKDVaqrgvRPSKKQLETVQkelETARKELKKMEeyidiekpiwKKIWEAEL 288
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491097   3251 KKVMsqEIQEQLHKQQEVIADkqmsVKEDLDKVEpaviEAQNAVKSIKKQHLVEVRSMANPPAAVKLALES 3321
Cdd:smart00806  289 DKVC--EEQQFLTLQEDLIAD----LKEDLEKAE----ETFDLVEQCCEEQEKGPSKNRNKPVSLPVPTPG 349
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
3187-3300 1.66e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.37  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3187 EKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKkMVKDQQEAEkkkVMSQEIqEQLHKQQ 3266
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG-NVRNNKEYE---ALQKEI-ESLKRRI 105
                          90       100       110
                  ....*....|....*....|....*....|....
gi 148491097 3267 EVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQ 3300
Cdd:COG1579   106 SDLEDEILELMERIEELEEELAELEAELAELEAE 139
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
3205-3493 1.78e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.56  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3205 KIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQ----EAEKKKVMSQEIQEqlhkqqeviADKQMSVKEDL 3280
Cdd:COG5185   254 KLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKekiaEYTKSIDIKKATES---------LEEQLAAAEAE 324
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3281 DKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLGESTTDWK------QIRSIIMRENFIPTIVNFSA 3354
Cdd:COG5185   325 QELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEEldsfkdTIESTKESLDEIPQNQRGYA 404
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3355 EEISDAIREKMKknymsNPSYNYEIVNRaslacgpmvkwAIAQL--NYADMLKRVEPLRNELQKLEDDAKDNQQK--ANE 3430
Cdd:COG5185   405 QEILATLEDTLK-----AADRQIEELQR-----------QIEQAtsSNEEVSKLLNELISELNKVMREADEESQSrlEEA 468
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148491097 3431 VEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSET 3493
Cdd:COG5185   469 YDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMR 531
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
3400-3504 2.32e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3400 YADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKS 3479
Cdd:TIGR02168  749 IAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES 828
                           90       100
                   ....*....|....*....|....*
gi 148491097  3480 LSAERERWEKTSETFKNQMSTIAGD 3504
Cdd:TIGR02168  829 LERRIAATERRLEDLEEQIEELSED 853
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
3394-3492 4.08e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3394 AIAQLNYADmLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKV-NR 3472
Cdd:COG4913   328 LEAQIRGNG-GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALeEA 406
                          90       100
                  ....*....|....*....|.
gi 148491097 3473 STALLKSLS-AERERWEKTSE 3492
Cdd:COG4913   407 LAEAEAALRdLRRELRELEAE 427
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
3243-3486 4.14e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3243 KDQQEAEKKKVmSQEIQEQLHKQQEVIADKQmSVKEDLDKVEPAVIEAQNAVKSIKKQHLV---EVRSMANPPAAVKLAL 3319
Cdd:COG4942    22 AAEAEAELEQL-QQEIAELEKELAALKKEEK-ALLKQLAALERRIAALARRIRALEQELAAleaELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3320 ESICLLLGEsttdwkQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNpsYNYEIVN--RASLACGPMVKWAIAQ 3397
Cdd:COG4942   100 EAQKEELAE------LLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP--ARREQAEelRADLAELAALRAELEA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3398 L--NYADMLKRVEPLRNELQKLEddakdnqqkaNEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTA 3475
Cdd:COG4942   172 EraELEALLAELEEERAALEALK----------AERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
                         250
                  ....*....|.
gi 148491097 3476 LLKSLSAERER 3486
Cdd:COG4942   242 RTPAAGFAALK 252
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3187-3307 7.41e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 7.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097  3187 EKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKK-------VMSQEIQ 3259
Cdd:TIGR02169  336 AEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREInelkrelDRLQEEL 415
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 148491097  3260 EQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSI--KKQHLVEVRS 3307
Cdd:TIGR02169  416 QRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQewKLEQLAADLS 465
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
2911-2968 7.48e-03

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 42.21  E-value: 7.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148491097 2911 NEVLDHVLRIDRIFRQ----PQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHR---KYTGE 2968
Cdd:COG0464   170 RELVALPLKRPELREEyglpPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDlvsKYVGE 234
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
1903-2019 8.43e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 8.43e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097   1903 FGPAGTGKTESVKALGHQLGR---FVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEA 1979
Cdd:smart00382    8 VGPPGSGKTTLARALARELGPpggGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILDEI 87
                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 148491097   1980 LReHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPG 2019
Cdd:smart00382   88 TS-LLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDE 126
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
2586-2615 8.65e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 42.10  E-value: 8.65e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148491097 2586 HKP--LVL-CGPPGSGKTMTLFSALRALPDMEV 2615
Cdd:COG2804   310 RRPhgIILvTGPTGSGKTTTLYAALNELNTPER 342
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
3401-3485 9.90e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491097 3401 ADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKE---------EYAVLISE---------------- 3455
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYEALQKEieslkrrisdledeil 113
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 148491097 3456 -----AQAIKADLAAVEAKVNRSTALLKSLSAERE 3485
Cdd:COG1579   114 elmerIEELEEELAELEAELAELEAELEEKKAELD 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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