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Conserved domains on  [gi|70906470|ref|NP_062674|]
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pseudouridylate synthase 1 homolog isoform 2 [Mus musculus]

Protein Classification

pseudouridine synthase family protein( domain architecture ID 10118740)

pseudouridine synthase family protein may catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines; similar to tRNA pseudouridine synthase 1

CATH:  3.30.2350.10
EC:  5.4.99.-
PubMed:  12762017|12756329
SCOP:  3001360

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PseudoU_synth_PUS1_PUS2 cd02568
Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine ...
84-336 2.36e-128

Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine synthases similar to Saccharomyces cerevisiae Pus1p, S. cerevisiae Pus2p, Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae Pus1p catalyzes the formation of psi34 and psi36 in the intron-containing tRNAIle, psi35 in the intron-containing tRNATyr, psi27 and/or psi28 in several yeast cytoplasmic tRNAs and, psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34, 35 and 36. In addition S. cerevisiae PUS1 makes are psi 26, 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. Mouse Pus1p makes psi27/28 in pre- tRNASer , tRNAVal and tRNAIle, psi 34/36 in tRNAIle and, psi 32 and potentially 67 in tRNAVal. Psi44 in U2 snRNA and psi32 in tRNAs are highly phylogenetically conserved. Psi 26,27,28,34,35,36,65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA).


:

Pssm-ID: 211335 [Multi-domain]  Cd Length: 245  Bit Score: 370.02  E-value: 2.36e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRNLGSsqFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLID--- 160
Cdd:cd02568   1 LLFGYCGTGYHGMQYNPGA--YKTIEGELERALFKAGAISESNAGDPKKIGFSRAARTDKGVHAARNVVSLKVIIDDpeg 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 161 -----DILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFahkdrdvqdesyrlsaETLQQVNRLLACY 235
Cdd:cd02568  79 lgileDLVEKLNSHLPSDIRVFGITRVTKSFNARKACDSRTYEYLLPTFAL----------------ETLQRFNEILKEY 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 236 KGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVR-EGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:cd02568 143 VGTHNFHNFTVKKKFEDPSANRFIKSFYVSEPFVIeEGLEWISIKIHGQSFMLHQIRKMIGLAIAIVRGGAPESLIELSF 222
                       250       260
                ....*....|....*....|...
gi 70906470 315 GEEKVD-VPKAPGLGLVLERVHF 336
Cdd:cd02568 223 NKDKIIiIPLAPGLGLLLERPHF 245
 
Name Accession Description Interval E-value
PseudoU_synth_PUS1_PUS2 cd02568
Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine ...
84-336 2.36e-128

Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine synthases similar to Saccharomyces cerevisiae Pus1p, S. cerevisiae Pus2p, Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae Pus1p catalyzes the formation of psi34 and psi36 in the intron-containing tRNAIle, psi35 in the intron-containing tRNATyr, psi27 and/or psi28 in several yeast cytoplasmic tRNAs and, psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34, 35 and 36. In addition S. cerevisiae PUS1 makes are psi 26, 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. Mouse Pus1p makes psi27/28 in pre- tRNASer , tRNAVal and tRNAIle, psi 34/36 in tRNAIle and, psi 32 and potentially 67 in tRNAVal. Psi44 in U2 snRNA and psi32 in tRNAs are highly phylogenetically conserved. Psi 26,27,28,34,35,36,65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA).


Pssm-ID: 211335 [Multi-domain]  Cd Length: 245  Bit Score: 370.02  E-value: 2.36e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRNLGSsqFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLID--- 160
Cdd:cd02568   1 LLFGYCGTGYHGMQYNPGA--YKTIEGELERALFKAGAISESNAGDPKKIGFSRAARTDKGVHAARNVVSLKVIIDDpeg 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 161 -----DILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFahkdrdvqdesyrlsaETLQQVNRLLACY 235
Cdd:cd02568  79 lgileDLVEKLNSHLPSDIRVFGITRVTKSFNARKACDSRTYEYLLPTFAL----------------ETLQRFNEILKEY 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 236 KGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVR-EGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:cd02568 143 VGTHNFHNFTVKKKFEDPSANRFIKSFYVSEPFVIeEGLEWISIKIHGQSFMLHQIRKMIGLAIAIVRGGAPESLIELSF 222
                       250       260
                ....*....|....*....|...
gi 70906470 315 GEEKVD-VPKAPGLGLVLERVHF 336
Cdd:cd02568 223 NKDKIIiIPLAPGLGLLLERPHF 245
TruA COG0101
tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]; ...
80-359 1.69e-59

tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223179 [Multi-domain]  Cd Length: 266  Bit Score: 194.79  E-value: 1.69e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  80 RKIVLLMAYSGKGYHGMQRNlgsSQFRTIEDDLVSALVQAGCIPEnhgtdmrkmSFQRCARTDKGVSAAGQVVSLKV--- 156
Cdd:COG0101   2 KRIALKIAYDGTRFHGWQRQ---PNVRTVQGELEKALSKIGGESV---------RVIGAGRTDAGVHALGQVVHFDTpad 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 157 WLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAF--AHKDRDVQDESYRLSAETLQQvnrLLAC 234
Cdd:COG0101  70 RPLEKLVRALNALLPPDIRVLDVAEVPDDFHARFSAKSRTYRYIIYNAPLrpPFLANYVWHVPYPLDLDAMRE---AAKL 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 235 YKGTHNFHNFTSQKGPREpSARRYILEMYCeepfVREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:COG0101 147 LLGTHDFTSFRKAGCQSK-SPVRTIYRIDV----SRDG-DLIVIDISGNSFLWHMVRNIVGALLLVGRGKRPVEWIKELL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 70906470 315 GEE--KVDVPKAPGLGLVLERVHFEKYNQrFGGDGLHEPLDWTQEEG 359
Cdd:COG0101 221 EAKdrKLAGPTAPAEGLYLVRVDYPEDFE-LPEDALGPKFLRSDGEE 266
hisT_truA TIGR00071
tRNA pseudouridine(38-40) synthase; Members of this family are the tRNA modification enzyme ...
80-331 2.33e-45

tRNA pseudouridine(38-40) synthase; Members of this family are the tRNA modification enzyme TruA, tRNA pseudouridine(38-40) synthase. In a few species (e.g. Bacillus anthracis), TruA is represented by two paralogs. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272889 [Multi-domain]  Cd Length: 227  Bit Score: 156.71  E-value: 2.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470    80 RKIVLLMAYSGKGYHGMQRNLGssqFRTIEDDLVSALVQAGcipenhgtdMRKMSFQRCARTDKGVSAAGQVVSLKvwLI 159
Cdd:TIGR00071   1 RKIALKIAYDGSNYHGWQRQPN---KRTVQGELEKALEAIG---------KKKITIMSAGRTDKGVHAMGQVISFD--TP 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   160 DDILD-----KINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPtfafaHKDRDVqdesYRLSAETLQQVnrlLAC 234
Cdd:TIGR00071  67 KEIPDnklnaKLNALLPPDIRVKALAPVNDNFHARFSASKRHYRYILY-----NHRHYY----SPLDLEKMRAA---AKQ 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   235 YKGTHNFHNFTSQKGPrEPSARRYILEMYceepfVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:TIGR00071 135 LLGKHDFSNFSKAKSK-SRSPIRTISDIK-----VSESGEYIIFDIIGNSFLWHMVRKIVGALVLVGRGKLPPEWVAKLL 208
                         250
                  ....*....|....*....
gi 70906470   315 GEEKVD--VPKAPGLGLVL 331
Cdd:TIGR00071 209 DAKKRNlaPTTAPANGLYL 227
truA PRK00021
tRNA pseudouridine(38-40) synthase TruA;
80-334 1.46e-33

tRNA pseudouridine(38-40) synthase TruA;


Pssm-ID: 234577 [Multi-domain]  Cd Length: 244  Bit Score: 125.64  E-value: 1.46e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   80 RKIVLLMAYSGKGYHGMQRnlgssQ--FRTIEDDLVSALvqagcipenhgtdmRKMSFQR----CA-RTDKGVSAAGQVV 152
Cdd:PRK00021   2 MRIALTIEYDGTNFHGWQR-----QpnGRTVQGELEKAL--------------SKLAGEPvrviGAgRTDAGVHALGQVA 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  153 SL---KVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPT--FAFAHKDRDVQDESYRLSAETLQQ 227
Cdd:PRK00021  63 HFdtpAPRPPEKWRRALNALLPDDIAVLWAEEVPDDFHARFSAKARRYRYRIYNrpARPPFLRGYVWHYPYPLDVDAMNE 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  228 VNRLLacyKGTHNFHNFTSQKGPREpSARRYILEMYCEepfvREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPE 307
Cdd:PRK00021 143 AAQYL---LGEHDFTSFRASGCQSK-SPVRTIYEADVT----REG-DFIVFDISANGFLHNMVRNIVGTLLEVGKGKRPP 213
                        250       260
                 ....*....|....*....|....*....
gi 70906470  308 SVLERSWGEEKVD--VPKAPGLGLVLERV 334
Cdd:PRK00021 214 EDIKELLEAKDRTlaGPTAPAEGLYLVEV 242
PseudoU_synth_1 pfam01416
tRNA pseudouridine synthase; Involved in the formation of pseudouridine at the anticodon stem ...
235-337 3.99e-15

tRNA pseudouridine synthase; Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.


Pssm-ID: 426254 [Multi-domain]  Cd Length: 108  Bit Score: 71.03  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   235 YKGTHNFHNFTSQKGPREPSaRRYILEMYCEEPFVREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLER-- 312
Cdd:pfam01416   5 YVGTHDFGNFCKQDQPKKNT-VRTILEAAVSRVPGEDG-DLIVFEVRGSGFLDHMVRAMVGVLFLVGQGKEPPEWIAEll 82
                          90       100
                  ....*....|....*....|....*.
gi 70906470   313 -SWGEEKVDVPKAPGLGLVLERVHFE 337
Cdd:pfam01416  83 nAKDPRKIAGPTAPPVGLYLFHVRYP 108
 
Name Accession Description Interval E-value
PseudoU_synth_PUS1_PUS2 cd02568
Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine ...
84-336 2.36e-128

Pseudouridine synthase, PUS1/ PUS2 like; This group consists of eukaryotic pseudouridine synthases similar to Saccharomyces cerevisiae Pus1p, S. cerevisiae Pus2p, Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae Pus1p catalyzes the formation of psi34 and psi36 in the intron-containing tRNAIle, psi35 in the intron-containing tRNATyr, psi27 and/or psi28 in several yeast cytoplasmic tRNAs and, psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34, 35 and 36. In addition S. cerevisiae PUS1 makes are psi 26, 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. Mouse Pus1p makes psi27/28 in pre- tRNASer , tRNAVal and tRNAIle, psi 34/36 in tRNAIle and, psi 32 and potentially 67 in tRNAVal. Psi44 in U2 snRNA and psi32 in tRNAs are highly phylogenetically conserved. Psi 26,27,28,34,35,36,65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA).


Pssm-ID: 211335 [Multi-domain]  Cd Length: 245  Bit Score: 370.02  E-value: 2.36e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRNLGSsqFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLID--- 160
Cdd:cd02568   1 LLFGYCGTGYHGMQYNPGA--YKTIEGELERALFKAGAISESNAGDPKKIGFSRAARTDKGVHAARNVVSLKVIIDDpeg 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 161 -----DILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFahkdrdvqdesyrlsaETLQQVNRLLACY 235
Cdd:cd02568  79 lgileDLVEKLNSHLPSDIRVFGITRVTKSFNARKACDSRTYEYLLPTFAL----------------ETLQRFNEILKEY 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 236 KGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVR-EGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:cd02568 143 VGTHNFHNFTVKKKFEDPSANRFIKSFYVSEPFVIeEGLEWISIKIHGQSFMLHQIRKMIGLAIAIVRGGAPESLIELSF 222
                       250       260
                ....*....|....*....|...
gi 70906470 315 GEEKVD-VPKAPGLGLVLERVHF 336
Cdd:cd02568 223 NKDKIIiIPLAPGLGLLLERPHF 245
TruA COG0101
tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]; ...
80-359 1.69e-59

tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223179 [Multi-domain]  Cd Length: 266  Bit Score: 194.79  E-value: 1.69e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  80 RKIVLLMAYSGKGYHGMQRNlgsSQFRTIEDDLVSALVQAGCIPEnhgtdmrkmSFQRCARTDKGVSAAGQVVSLKV--- 156
Cdd:COG0101   2 KRIALKIAYDGTRFHGWQRQ---PNVRTVQGELEKALSKIGGESV---------RVIGAGRTDAGVHALGQVVHFDTpad 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 157 WLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAF--AHKDRDVQDESYRLSAETLQQvnrLLAC 234
Cdd:COG0101  70 RPLEKLVRALNALLPPDIRVLDVAEVPDDFHARFSAKSRTYRYIIYNAPLrpPFLANYVWHVPYPLDLDAMRE---AAKL 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 235 YKGTHNFHNFTSQKGPREpSARRYILEMYCeepfVREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:COG0101 147 LLGTHDFTSFRKAGCQSK-SPVRTIYRIDV----SRDG-DLIVIDISGNSFLWHMVRNIVGALLLVGRGKRPVEWIKELL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 70906470 315 GEE--KVDVPKAPGLGLVLERVHFEKYNQrFGGDGLHEPLDWTQEEG 359
Cdd:COG0101 221 EAKdrKLAGPTAPAEGLYLVRVDYPEDFE-LPEDALGPKFLRSDGEE 266
PseudoU_synth_TruA_like cd00497
Pseudouridine synthase, TruA family; This group consists of eukaryotic, bacterial and archeal ...
87-336 8.23e-49

Pseudouridine synthase, TruA family; This group consists of eukaryotic, bacterial and archeal pseudouridine synthases similar to Escherichia coli TruA, Saccharomyces cerevisiae Pus1p, S. cerevisiae Pus3p Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae PUS1 catalyzes the formation of psi34 and psi36 in the intron containing tRNAIle, psi35 in the intron containing tRNATyr, psi27 and/or psi28 in several yeast cytoplasmic tRNAs and, psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34, 35 and 36. In addition S. cerevisiae PUS1 makes psi 26, 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. S. cerevisiae Pus3p makes psi38 and psi39 in tRNAs. Psi44 in U2 snRNA and, psi38 and psi39 in tRNAs are highly phylogenetically conserved. Psi 26,27,28,34,35,36,65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA).


Pssm-ID: 211322 [Multi-domain]  Cd Length: 215  Bit Score: 165.25  E-value: 8.23e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  87 AYSGKGYHGMQRnlgSSQFRTIEDDLVSALVQAGCIPENhgtdmrkmsFQRCARTDKGVSAAGQVVSLKV--WLIDDIld 164
Cdd:cd00497   2 GYDGTKYHGFQR---QNDVPTVEGELIIALLKAGNIPYF---------IKAAARTDRGVSALGQVVAIETerRLTPEA-- 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 165 kINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFafahkdrDVQDESyrlsaetlqqVNRLLACYKGTHNFHNF 244
Cdd:cd00497  68 -LNGILPGDIRVFAVHSVPPDFHAPRYCDHRTYRYYIPSF-------PLDDER----------LKSAASRFLGTHDFTNF 129
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 245 TSQKGpREPsaRRYILEMYCEEPFvreglEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPK- 323
Cdd:cd00497 130 SKKDT-RNT--VRTIISIECKDLN-----PFVVVEFKAKSFLWHQVRRMVGFLMLVGEGLHSPSSVSRLLAGPAPPIPMv 201
                       250
                ....*....|....
gi 70906470 324 -APGLGLVLERVHF 336
Cdd:cd00497 202 pAPAEGLLLVDVKY 215
hisT_truA TIGR00071
tRNA pseudouridine(38-40) synthase; Members of this family are the tRNA modification enzyme ...
80-331 2.33e-45

tRNA pseudouridine(38-40) synthase; Members of this family are the tRNA modification enzyme TruA, tRNA pseudouridine(38-40) synthase. In a few species (e.g. Bacillus anthracis), TruA is represented by two paralogs. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272889 [Multi-domain]  Cd Length: 227  Bit Score: 156.71  E-value: 2.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470    80 RKIVLLMAYSGKGYHGMQRNLGssqFRTIEDDLVSALVQAGcipenhgtdMRKMSFQRCARTDKGVSAAGQVVSLKvwLI 159
Cdd:TIGR00071   1 RKIALKIAYDGSNYHGWQRQPN---KRTVQGELEKALEAIG---------KKKITIMSAGRTDKGVHAMGQVISFD--TP 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   160 DDILD-----KINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPtfafaHKDRDVqdesYRLSAETLQQVnrlLAC 234
Cdd:TIGR00071  67 KEIPDnklnaKLNALLPPDIRVKALAPVNDNFHARFSASKRHYRYILY-----NHRHYY----SPLDLEKMRAA---AKQ 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   235 YKGTHNFHNFTSQKGPrEPSARRYILEMYceepfVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSW 314
Cdd:TIGR00071 135 LLGKHDFSNFSKAKSK-SRSPIRTISDIK-----VSESGEYIIFDIIGNSFLWHMVRKIVGALVLVGRGKLPPEWVAKLL 208
                         250
                  ....*....|....*....
gi 70906470   315 GEEKVD--VPKAPGLGLVL 331
Cdd:TIGR00071 209 DAKKRNlaPTTAPANGLYL 227
truA PRK00021
tRNA pseudouridine(38-40) synthase TruA;
80-334 1.46e-33

tRNA pseudouridine(38-40) synthase TruA;


Pssm-ID: 234577 [Multi-domain]  Cd Length: 244  Bit Score: 125.64  E-value: 1.46e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   80 RKIVLLMAYSGKGYHGMQRnlgssQ--FRTIEDDLVSALvqagcipenhgtdmRKMSFQR----CA-RTDKGVSAAGQVV 152
Cdd:PRK00021   2 MRIALTIEYDGTNFHGWQR-----QpnGRTVQGELEKAL--------------SKLAGEPvrviGAgRTDAGVHALGQVA 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  153 SL---KVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPT--FAFAHKDRDVQDESYRLSAETLQQ 227
Cdd:PRK00021  63 HFdtpAPRPPEKWRRALNALLPDDIAVLWAEEVPDDFHARFSAKARRYRYRIYNrpARPPFLRGYVWHYPYPLDVDAMNE 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  228 VNRLLacyKGTHNFHNFTSQKGPREpSARRYILEMYCEepfvREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPE 307
Cdd:PRK00021 143 AAQYL---LGEHDFTSFRASGCQSK-SPVRTIYEADVT----REG-DFIVFDISANGFLHNMVRNIVGTLLEVGKGKRPP 213
                        250       260
                 ....*....|....*....|....*....
gi 70906470  308 SVLERSWGEEKVD--VPKAPGLGLVLERV 334
Cdd:PRK00021 214 EDIKELLEAKDRTlaGPTAPAEGLYLVEV 242
PLN03078 PLN03078
Putative tRNA pseudouridine synthase; Provisional
79-337 1.95e-30

Putative tRNA pseudouridine synthase; Provisional


Pssm-ID: 215562 [Multi-domain]  Cd Length: 513  Bit Score: 122.70  E-value: 1.95e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   79 KRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKV-- 156
Cdd:PLN03078  70 KKKVVLRVGYVGTDYRGLQKQRDLSSLSTIEGELETAIFKAGGIRESNYGNLHKIGWARSSRTDKGVHSLATMISLKMei 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  157 ----WLIDD---ILDK-INSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDEsyrlSAETLQQV 228
Cdd:PLN03078 150 penaWKDDPdgiALAKfINSHLPDNIRVFSILPAQRSFDPRRECDLRKYSYLLPAEVIGIKSGFSSEE----IDEHISEF 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  229 NRLLACYKGTHNFHNFTSQ------------------------------------------------------------- 247
Cdd:PLN03078 226 NSILNGFEGEHPFHNYTARskyrkklpgkhkqrngavsrraksskemssseseenhgeiseedeedlsfssipsgssden 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  248 -KGPREPSARRYILEMYCEEPFVRE----------------------GLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGY 304
Cdd:PLN03078 306 eDILKFQSSQVQIRARWLHEPDETDrisashfrkifrcscgklekslGFDFVELSIWGESFMLHQIRKMVGTAVAVKREL 385
                        330       340       350
                 ....*....|....*....|....*....|....
gi 70906470  305 APESVLERSWGE-EKVDVPKAPGLGLVLERVHFE 337
Cdd:PLN03078 386 LPRDIIRLSLTKfSRIVLPLAPSEVLILRGNSFS 419
PseudoU_synth_EcTruA cd02570
Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; This group consists ...
84-334 1.32e-29

Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1). Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E. coli TruA makes psi38/39 and/or 40 in tRNA. psi38 and psi39 in tRNAs are highly phylogenetically conserved. P. aeruginosa truA is required for induction of type III secretory genes and may act through modifying tRNAs critical for the expression of type III genes or their regulators.


Pssm-ID: 211337 [Multi-domain]  Cd Length: 239  Bit Score: 114.88  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRnlgssQ--FRTIEDDLVSALvqagcipenhgtdmRKMSFQR----CA-RTDKGVSAAGQVVSLKV 156
Cdd:cd02570   1 LTIEYDGTNFSGWQR-----QpnGRTVQGELEKAL--------------SKIAGEPvrviGAgRTDAGVHALGQVAHFDT 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 157 ---WLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLptfaFAHKDRDVQDESY------RLSAETLQQ 227
Cdd:cd02570  62 pseIPLEKLIKALNSLLPPDIRVLSAEEVPDDFHARFSAKSRTYRYRI----LNRPVPSPFLRRYvwhvprPLDIEAMQE 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 228 VNRLLacyKGTHNFHNFTSQKGPRePSARRYILEmyCEepfVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKG-YAP 306
Cdd:cd02570 138 AAKLL---LGTHDFSSFRAAGCQS-KSTVRTIYR--AD---VYREGDLIVFEIRANGFLYHMVRNIVGTLLEVGRGkLSP 208
                       250       260       270
                ....*....|....*....|....*....|....*
gi 70906470 307 ESVLE-------RSWGeekvdvPKAPGLGLVLERV 334
Cdd:cd02570 209 EDIKEileakdrTAAG------PTAPAHGLYLVKV 237
PseudoU_synth_ScPus3 cd02569
Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like; This group consists of eukaryotic ...
84-336 1.50e-27

Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like; This group consists of eukaryotic pseudouridine synthases similar to S. cerevisiae Pus3p, mouse Pus3p and, human PUS2. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae Pus3p makes psi38 and psi39 in tRNAs. Mouse Pus3p has been shown to makes psi38 and, possibly also psi 39, in tRNAs. Psi38 and psi39 are highly conserved in tRNAs from eubacteria, archea and eukarya.


Pssm-ID: 211336 [Multi-domain]  Cd Length: 256  Bit Score: 109.68  E-value: 1.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRNLGSSQfrTIEDDLVSALVQAGCIPenhgtDMRKMSFQRCARTDKGVSAAGQVVSLKV------- 156
Cdd:cd02569   1 LRFAYLGWNYNGFAVQEETTN--TVEETLFEALEKTRLIE-----DRQTSNYSRCGRTDKGVSAFGQVISLDVrsnlkpe 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 157 WLIDDILDK--------------INSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYmlptfAFAHKDRDVqdesyrlsa 222
Cdd:cd02569  74 DGLDPSTDVkstadeeelpyckiLNRVLPPDIRILAWAPVPPDFSARFSCVSRTYRY-----FFPKGDLDI--------- 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 223 ETLQQVNRLlacYKGTHNFHNFTSQKGPREP-SARRYILEMYCEE-PFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAI 300
Cdd:cd02569 140 ELMRKAAKL---LLGEHDFRNFCKMDVANQVtNYVRRVLSAEVEPvDQHPDGDGLYYFEVRGSAFLWHQVRCMMAVLFLI 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 70906470 301 VKGYAPESVLERSWGEEKvdVPK------APGLGLVLERVHF 336
Cdd:cd02569 217 GQGLEPPSVISQLLDVEK--NPRkpqytmASEVPLVLYDCGF 256
PseudoU_synth_TruA_Archea cd02866
Archeal pseudouridine synthases; This group consists of archeal pseudouridine synthases. ...
84-331 9.20e-26

Archeal pseudouridine synthases; This group consists of archeal pseudouridine synthases.Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. This group of proteins make Psedouridine in tRNAs.


Pssm-ID: 211343 [Multi-domain]  Cd Length: 219  Bit Score: 104.00  E-value: 9.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  84 LLMAYSGKGYHGMQRNlgsSQFRTIEDDLVSALVQAGCIPEnhgtdmrKMSFQRCARTDKGVSAAGQVVSlkVWLIDD-I 162
Cdd:cd02866   1 LKIAYDGTNFHGFQRQ---PDVRTVEGELIKALEELGIIES-------RARLYSAGRTDRGVHALGNVVV--FETEKEpI 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 163 LDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPtfafahkdrdvqdESYRLSAetLQQVNRLLacyKGTHNFH 242
Cdd:cd02866  69 PPMINAKLPKDIWVLAGAKVPEDFDPRRWAHRKYYRYNLG-------------SDYDVEA--MKEAAKKL---IGTHDFS 130
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470 243 NFTSQKGPREPSARRYILEmyceepfVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLER--SWGEEKVD 320
Cdd:cd02866 131 NFSKRDGRKDPVRTIERIE-------ISENGEFITIDVVGESFLWNMVRRIVGALSEVGKGKRENEWVEKllDGEFRPEG 203
                       250
                ....*....|.
gi 70906470 321 VPKAPGLGLVL 331
Cdd:cd02866 204 VPPAPPEGLIL 214
PseudoU_synth_1 pfam01416
tRNA pseudouridine synthase; Involved in the formation of pseudouridine at the anticodon stem ...
235-337 3.99e-15

tRNA pseudouridine synthase; Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.


Pssm-ID: 426254 [Multi-domain]  Cd Length: 108  Bit Score: 71.03  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470   235 YKGTHNFHNFTSQKGPREPSaRRYILEMYCEEPFVREGlEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLER-- 312
Cdd:pfam01416   5 YVGTHDFGNFCKQDQPKKNT-VRTILEAAVSRVPGEDG-DLIVFEVRGSGFLDHMVRAMVGVLFLVGQGKEPPEWIAEll 82
                          90       100
                  ....*....|....*....|....*.
gi 70906470   313 -SWGEEKVDVPKAPGLGLVLERVHFE 337
Cdd:pfam01416  83 nAKDPRKIAGPTAPPVGLYLFHVRYP 108
PRK14587 PRK14587
tRNA pseudouridine synthase ACD; Provisional
137-331 1.92e-10

tRNA pseudouridine synthase ACD; Provisional


Pssm-ID: 173051  Cd Length: 256  Bit Score: 61.00  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  137 RCARTDKGVSAAGQVVSLKVWLiddILDKINSHLPSHIRILGLKRVTGGFNSKnKCDARTYCYMLPtfafaHKDRDVqdE 216
Cdd:PRK14587  38 RGSRTDPGVSAVGNVVMTSQKL---PLGYVNSKLPRGVWAWAVAEVPEGFNPR-RAKRRRYLYVAP-----HWGEDV--E 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70906470  217 SYRLSAETLqqvnrllacyKGTHNFHNFTSQKGPREPSARRYILEMYCEepfVREGLEFavIKVKGQSFMMHQIRKMVGL 296
Cdd:PRK14587 107 AMREAAELL----------AGTHDYSSFIQRRGEKATPTVTTVYEIGVE---LRGDLIY--LYFVGRGFRNKMIRKMAWA 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 70906470  297 VVAIVKGyapesVLERSWGEEKVD------VPKAPGLGLVL 331
Cdd:PRK14587 172 ILAAGRG-----VLSRRDIAELLErprpgaVPSAPAEGLVL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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