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Conserved domains on  [gi|255069719|ref|NP_062690|]
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origin recognition complex subunit 6 isoform a [Mus musculus]

Protein Classification

Orc6_mid and ORC6_CTD domain-containing protein( domain architecture ID 11030016)

protein containing domains Orc6_mid, and ORC6_CTD

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-186 1.65e-25

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


:

Pssm-ID: 211425  Cd Length: 94  Bit Score: 96.21  E-value: 1.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719  94 SNVGIRDLAVQFSCTEAVNLAAEILQSYESGLPET-QRADLDLSRPLFTTAALLSACKILKIKVDKTKMITASGVKKAIL 172
Cdd:cd11583    1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACKKLKVKVDKSKLLEVSGVDPSIF 80

                         90
                 ....*....|....
gi 255069719 173 DRLCKQLEKIGQQI 186
Cdd:cd11583   81 DRLCASMEKLCKDI 94
Orc6_mid super family cl21687
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 6-94 3.82e-14

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


The actual alignment was detected with superfamily member pfam05460:

Pssm-ID: 389868 [Multi-domain]  Cd Length: 288  Bit Score: 70.38  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719    6 VRRLAPRLGLAEPS-VLRKAEEFLRLSKVKCVSLSARSsETSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMVYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 255069719   85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
ORC6_CTD cd16075
C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a ...
 211-259 1.84e-09

C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a complex consisting of six subunits promotes the onset of DNA replication. The 6th subunit, ORC6, does not belong to the wider AAA+ family of nucleotide hydrolases, but contains a tandemly repeated domain resembling the transcription factor TFIIB, as well as this C-terminal domain which harbors a helical segment that is responsible for interactions with the complex by binding to ORC3. Mutations in this C-terminal helix interfere with the formation of the ORC and have been linked to Meier-Gorlin syndrome, a dwarfism disorder.


:

Pssm-ID: 293922  Cd Length: 53  Bit Score: 52.34  E-value: 1.84e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 255069719 211 KKEPGLEPPAKEIEVIETlhKLPKDED-LTQDYEEWKRKILENAAKAQTA 259
Cdd:cd16075    6 LKERYFEEKEKEEEVERS--KQQKSEKeTIEDYEEWKRRILENAAKALKE 53
 
Name Accession Description Interval E-value
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-186 1.65e-25

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 96.21  E-value: 1.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719  94 SNVGIRDLAVQFSCTEAVNLAAEILQSYESGLPET-QRADLDLSRPLFTTAALLSACKILKIKVDKTKMITASGVKKAIL 172
Cdd:cd11583    1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACKKLKVKVDKSKLLEVSGVDPSIF 80

                         90
                 ....*....|....
gi 255069719 173 DRLCKQLEKIGQQI 186
Cdd:cd11583   81 DRLCASMEKLCKDI 94
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
 6-94 3.82e-14

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 70.38  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719    6 VRRLAPRLGLAEPS-VLRKAEEFLRLSKVKCVSLSARSsETSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMVYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 255069719   85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
ORC6_CTD cd16075
C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a ...
 211-259 1.84e-09

C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a complex consisting of six subunits promotes the onset of DNA replication. The 6th subunit, ORC6, does not belong to the wider AAA+ family of nucleotide hydrolases, but contains a tandemly repeated domain resembling the transcription factor TFIIB, as well as this C-terminal domain which harbors a helical segment that is responsible for interactions with the complex by binding to ORC3. Mutations in this C-terminal helix interfere with the formation of the ORC and have been linked to Meier-Gorlin syndrome, a dwarfism disorder.


Pssm-ID: 293922  Cd Length: 53  Bit Score: 52.34  E-value: 1.84e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 255069719 211 KKEPGLEPPAKEIEVIETlhKLPKDED-LTQDYEEWKRKILENAAKAQTA 259
Cdd:cd16075    6 LKERYFEEKEKEEEVERS--KQQKSEKeTIEDYEEWKRRILENAAKALKE 53
 
Name Accession Description Interval E-value
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-186 1.65e-25

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 96.21  E-value: 1.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719  94 SNVGIRDLAVQFSCTEAVNLAAEILQSYESGLPET-QRADLDLSRPLFTTAALLSACKILKIKVDKTKMITASGVKKAIL 172
Cdd:cd11583    1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACKKLKVKVDKSKLLEVSGVDPSIF 80

                         90
                 ....*....|....
gi 255069719 173 DRLCKQLEKIGQQI 186
Cdd:cd11583   81 DRLCASMEKLCKDI 94
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
 6-94 3.82e-14

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 70.38  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255069719    6 VRRLAPRLGLAEPS-VLRKAEEFLRLSKVKCVSLSARSsETSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMVYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 255069719   85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
ORC6_CTD cd16075
C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a ...
 211-259 1.84e-09

C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a complex consisting of six subunits promotes the onset of DNA replication. The 6th subunit, ORC6, does not belong to the wider AAA+ family of nucleotide hydrolases, but contains a tandemly repeated domain resembling the transcription factor TFIIB, as well as this C-terminal domain which harbors a helical segment that is responsible for interactions with the complex by binding to ORC3. Mutations in this C-terminal helix interfere with the formation of the ORC and have been linked to Meier-Gorlin syndrome, a dwarfism disorder.


Pssm-ID: 293922  Cd Length: 53  Bit Score: 52.34  E-value: 1.84e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 255069719 211 KKEPGLEPPAKEIEVIETlhKLPKDED-LTQDYEEWKRKILENAAKAQTA 259
Cdd:cd16075    6 LKERYFEEKEKEEEVERS--KQQKSEKeTIEDYEEWKRRILENAAKALKE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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